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arsenic and 4-(n-(s-glutathionylacetyl)amino)phenylarsenoxide

arsenic has been researched along with 4-(n-(s-glutathionylacetyl)amino)phenylarsenoxide in 18 studies

Research

Studies (18)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's9 (50.00)29.6817
2010's9 (50.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Donoghue, N; Hogg, PJ; Jiang, XM; Yam, PT1
Hogg, PJ; Jiang, XM; Mutus, B; Ramachandran, N; Root, P1
Donoghue, N; Hogg, PJ2
Donoghue, N; Hogg, PJ; Jiang, XM; Li, P; Matthias, LJ; Poumbourios, P; Vandegraaff, N; Yam, PT1
Allen, JD; Dawes, IW; Dilda, PJ; Don, AS; Higgins, VJ; Hogg, PJ; Tanabe, KM1
Decollogne, S; Dilda, PJ; Hogg, PJ; Rossiter-Thornton, M1
Cadd, VA; Feller, SM; Harris, AL; Hogg, PJ1
Corti, A; Dilda, PJ; Hogg, PJ; Pompella, A; Ramsay, EE1
Dick, LJ; Elliott, MA; Farmer, H; Ford, SJ; Halbert, GW; Hogg, PJ; Prasad, E1
Blankevoort, V; Chan, A; Hogg, PJ; Kaijzel, EL; Löwik, CW; Orabi, Y; Park, D; Que, I; Van Beek, ER; Xie, BW1
Backen, A; Clamp, A; Cummings, J; Dawson, M; Dive, C; Farmer, H; Fisher, N; Halbert, G; Halford, S; Harris, A; Hasan, J; Hogg, P; Horsley, L; Jayson, GC; Kumaran, G; Little, R; Middleton, M; Parker, GJ; Potter, P; Roberts, C; Saunders, M; Shaw, D; Smith, N; Smythe, J; Taylor, A; Turner, H; Ward, T; Watson, Y1
de Haas, HJ; Dyszlewski, M; Fuster, V; Imaizumi, T; Kini, A; Narula, J; Narula, N; Pandurangi, R; Petrov, A; Reutelingsperger, C; Scarabelli, T; Slart, RH; Tahara, N; Yamaki, T; Zandbergen, HR; Zhou, J1
Harrington, CF; Taylor, A1
Abeynaike, L; Campbell, H; Chen, VM; Glaros, E; Hogg, PJ; Hua, VM; Pasalic, L1
Boersma, HH; de Haas, HJ; Haider, N; Kini, A; Mohar, D; Narula, J; Petrov, A; Scarabelli, T; Strauss, HW; Tahara, A; Tahara, N; Takeishi, Y; Yamaki, T; Zhou, J1
Campbell, H; Chen, VM; Connor, D; Hogg, PJ; Kritharides, L; Lau, E; Lau, JK; Liang, HP; Muller, D; Pasalic, L; Pennings, GJ; Wing-Lun, E1
Codd, R; Gotsbacher, MP; Guille, J; Ho Shon, I; Hogg, P; Kumar, D1

Trials

2 trial(s) available for arsenic and 4-(n-(s-glutathionylacetyl)amino)phenylarsenoxide

ArticleYear
Pharmaceutical development of the novel arsenical based cancer therapeutic GSAO for Phase I clinical trial.
    International journal of pharmaceutics, 2012, Apr-15, Volume: 426, Issue:1-2

    Topics: Angiogenesis Inhibitors; Antioxidants; Arsenicals; Calorimetry, Differential Scanning; Chemistry, Pharmaceutical; Drug Compounding; Drug Stability; Freeze Drying; Glutathione; Glycine; Humans; Hydrogen-Ion Concentration; Infusions, Intravenous; Neoplasms; Neovascularization, Pathologic; Oxidation-Reduction; Potentiometry; Technology, Pharmaceutical; Time Factors

2012
A phase 1 trial of intravenous 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO) in patients with advanced solid tumours.
    Cancer chemotherapy and pharmacology, 2013, Volume: 72, Issue:6

    Topics: Adult; Aged; Antineoplastic Agents; Arsenicals; Cell Proliferation; Dose-Response Relationship, Drug; Female; Glutathione; Humans; Infusions, Intravenous; Liver Function Tests; Magnetic Resonance Imaging; Male; Maximum Tolerated Dose; Middle Aged; Neoplasms; Neovascularization, Pathologic

2013

Other Studies

16 other study(ies) available for arsenic and 4-(n-(s-glutathionylacetyl)amino)phenylarsenoxide

ArticleYear
Presence of closely spaced protein thiols on the surface of mammalian cells.
    Protein science : a publication of the Protein Society, 2000, Volume: 9, Issue:12

    Topics: Animals; Arsenicals; Biotin; Electrophoresis, Polyacrylamide Gel; Endothelium; Fibrosarcoma; Glutathione; Humans; Indicators and Reagents; Mammals; Membrane Proteins; Oxidation-Reduction; Protein Disulfide-Isomerases; Sulfhydryl Compounds; Thioredoxins

2000
Mechanism of transfer of NO from extracellular S-nitrosothiols into the cytosol by cell-surface protein disulfide isomerase.
    Proceedings of the National Academy of Sciences of the United States of America, 2001, Aug-14, Volume: 98, Issue:17

    Topics: Animals; Antioxidants; Arsenicals; Cricetinae; Cytosol; Dansyl Compounds; Dithionitrobenzoic Acid; Endothelium, Vascular; Enzyme Inhibitors; Fibroblasts; Fibrosarcoma; Fluorescent Dyes; Glutathione; Homocysteine; Humans; Kinetics; Lung; Microscopy, Fluorescence; Molecular Chaperones; Nitric Oxide; Protein Disulfide-Isomerases; Protein Transport; Serum Albumin, Bovine; Tumor Cells, Cultured; Vitamin E

2001
Characterization of redox-active proteins on cell surface.
    Methods in enzymology, 2002, Volume: 348

    Topics: Arsenicals; Cell Line; Cell Membrane; Glutathione; Humans; Lysine; Maleimides; Membrane Proteins; Molecular Probes; Oxidation-Reduction

2002
Disulfide exchange in domain 2 of CD4 is required for entry of HIV-1.
    Nature immunology, 2002, Volume: 3, Issue:8

    Topics: Arsenicals; Biotin; CD4 Antigens; CD4-Positive T-Lymphocytes; Cysteine; Glutathione; HIV-1; Humans; Immunoblotting; Lysine; Maleimides; Mutation; Oxidation-Reduction; Protein Structure, Tertiary; Receptors, HIV; Succinimides; Sulfhydryl Compounds; Thioredoxins

2002
Identification of redox-active proteins on cell surface.
    Methods in enzymology, 2002, Volume: 352

    Topics: Arsenicals; Biochemistry; Cell Membrane; Disulfides; Dose-Response Relationship, Drug; Glutathione; Hydrogen-Ion Concentration; Indicators and Reagents; Lysine; Maleimides; Models, Chemical; Oxidation-Reduction; Oxygen

2002
Mechanism of selectivity of an angiogenesis inhibitor from screening a genome-wide set of Saccharomyces cerevisiae deletion strains.
    Journal of the National Cancer Institute, 2005, Oct-19, Volume: 97, Issue:20

    Topics: Angiogenesis Inhibitors; Animals; Apoptosis; Arsenicals; Cell Proliferation; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Endothelium, Vascular; Gene Deletion; Gene Expression Regulation, Neoplastic; Genome, Fungal; Glutathione; Immunoblotting; Mitochondrial Proteins; Multidrug Resistance-Associated Proteins; Ribosomal Proteins; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Transfection; Tumor Cells, Cultured; Up-Regulation

2005
Para to ortho repositioning of the arsenical moiety of the angiogenesis inhibitor 4-(N-(S-glutathionylacetyl)amino)phenylarsenoxide results in a markedly increased cellular accumulation and antiproliferative activity.
    Cancer research, 2005, Dec-15, Volume: 65, Issue:24

    Topics: Angiogenesis Inhibitors; Animals; Aorta; Arsenicals; Cattle; Cell Proliferation; Endothelium, Vascular; Female; Glutathione; Mice; Mice, Inbred BALB C; Mice, Nude; Mitochondria; Mitochondrial ADP, ATP Translocases; Multidrug Resistance-Associated Proteins; Neovascularization, Pathologic; Pancreatic Neoplasms; Stereoisomerism; Superoxides; Toluene

2005
Molecular profiling of signalling proteins for effects induced by the anti-cancer compound GSAO with 400 antibodies.
    BMC cancer, 2006, Jun-09, Volume: 6

    Topics: Adult; Antibodies; Arsenicals; Cells, Cultured; Culture Media; Culture Media, Serum-Free; Drug Evaluation, Preclinical; Endothelial Cells; Female; Glutathione; Humans; In Vitro Techniques; Leukocytes; Male; Middle Aged; Models, Biological; Phosphotransferases; Protein Array Analysis; Signal Transduction; Substrate Specificity

2006
Metabolism of the tumor angiogenesis inhibitor 4-(N-(S-Glutathionylacetyl)amino)phenylarsonous acid.
    The Journal of biological chemistry, 2008, Dec-19, Volume: 283, Issue:51

    Topics: Angiogenesis Inhibitors; Animals; Arsenicals; Biological Transport; Cattle; Cells, Cultured; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Endothelial Cells; gamma-Glutamyltransferase; Glutathione; Male; Mitochondria, Liver; Mitochondrial ADP, ATP Translocases; Neovascularization, Pathologic; Organic Anion Transporters; Rats; Rats, Wistar

2008
Optical imaging of cell death in traumatic brain injury using a heat shock protein-90 alkylator.
    Cell death & disease, 2013, Jan-24, Volume: 4

    Topics: Alkylation; Animals; Apoptosis; Arsenicals; Brain Injuries; Cell Line, Tumor; Disease Models, Animal; Fluorescent Dyes; Glutathione; HSP90 Heat-Shock Proteins; Humans; Jurkat Cells; Mice; Spectroscopy, Near-Infrared

2013
Noninvasive molecular imaging of cell death in myocardial infarction using 111In-GSAO.
    Scientific reports, 2014, Oct-29, Volume: 4

    Topics: Animals; Annexin A5; Arsenicals; Disease Models, Animal; Glutathione; Indium; Male; Mice; Microscopy, Fluorescence; Molecular Imaging; Myocardial Infarction; Rabbits; Radionuclide Imaging; Technetium

2014
Analytical approaches to investigating metal-containing drugs.
    Journal of pharmaceutical and biomedical analysis, 2015, Mar-15, Volume: 106

    Topics: Animals; Antineoplastic Agents; Arsenicals; Chromatography, Liquid; Cisplatin; Glutathione; Humans; Mass Spectrometry; Spectrophotometry, Atomic

2015
Necrotic platelets provide a procoagulant surface during thrombosis.
    Blood, 2015, Dec-24, Volume: 126, Issue:26

    Topics: Animals; Arsenicals; Biomarkers; Blood Platelets; Cells, Cultured; Cyclophilins; Flow Cytometry; Glutathione; Humans; Mice; Microscopy, Confocal; Necrosis; Platelet Activation; Thrombosis

2015
Cardioprotection by minocycline in a rabbit model of ischemia/reperfusion injury: Detection of cell death by in vivo
    Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2018, Volume: 25, Issue:1

    Topics: Animals; Arsenicals; Cell Death; Disease Models, Animal; Glutathione; Heart; Indium Radioisotopes; Minocycline; Multimodal Imaging; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Rabbits; Tomography, Emission-Computed, Single-Photon; Tomography, X-Ray Computed

2018
Novel assay demonstrates that coronary artery disease patients have heightened procoagulant platelet response.
    Journal of thrombosis and haemostasis : JTH, 2018, Volume: 16, Issue:6

    Topics: Aged; Arsenicals; Aspirin; Biomarkers; Blood Coagulation; Blood Platelets; Case-Control Studies; Clopidogrel; Coronary Angiography; Coronary Artery Disease; Drug Resistance; Female; Flow Cytometry; Glutathione; Humans; Male; Middle Aged; P-Selectin; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Function Tests; Predictive Value of Tests

2018
Preparation of a Dithiol-Reactive Probe for PET Imaging of Cell Death.
    Methods in molecular biology (Clifton, N.J.), 2019, Volume: 1967

    Topics: Acetates; Animals; Arsenicals; Cell Death; Gallium Radioisotopes; Glutathione; Heterocyclic Compounds, 1-Ring; Humans; Positron-Emission Tomography; Radioisotopes; Radiopharmaceuticals; Toluene

2019