arsenic has been researched along with Cell Transformation, Neoplastic in 174 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (6.32) | 18.7374 |
| 1990's | 9 (5.17) | 18.2507 |
| 2000's | 47 (27.01) | 29.6817 |
| 2010's | 91 (52.30) | 24.3611 |
| 2020's | 16 (9.20) | 2.80 |
| Authors | Studies |
|---|---|
| Chiu, JF; Huang, N; Li, G; Lin, W; Pei, X; Tao, T | 1 |
| Chan, TC; Chang, WR; Chiou, SH; Fang, KM; Lin, TC; Liu, JJ; Ma, SZ; Tzeng, SF; Tzou, BC; Yang, CS | 1 |
| Ayoubi, HR; Bazarbachi, AA; Bitar, NM; De Thé, HB; El Eit, RM; Iskandarani, AN; Jabbour, MN; Mahfouz, RA; Mahon, FX; Nasr, RR; Saliba, JL; Zaatari, GS | 1 |
| Kojima, C; Tokar, EJ; Waalkes, MP | 1 |
| Dos Santos, GA; Kats, L; Pandolfi, PP | 1 |
| de Thé, H; Rice, KL | 1 |
| Hasan, SK; Lo-Coco, F | 1 |
| Ablain, J; de Reynies, A; de Thé, H; Halftermeyer, J; Le Bras, M; Metzger, D; Peres, L; Vitaliano-Prunier, A | 1 |
| Huang, HS; Liu, ZM; Tseng, HY; Wu, WJ; Yeh, BW | 1 |
| Gao, B; Lu, M; Meng, X; Miao, Z; Qiao, X; Wu, L; Xue, D; Zhang, W | 1 |
| An, Y; Hoshino, M; Kato, K; Mizoi, M; Nakanao, M; Okada, S; Yamanaka, K | 1 |
| Mandal, P | 1 |
| Gou, BD; Wang, K; Wang, LW; Wang, N; Zhang, TL | 1 |
| Brossart, P; Czarnocka, B; Fröhlich, E; Wahl, R | 1 |
| Eblin, KE; Futscher, BW; Gandolfi, AJ; Jensen, TJ; Wnek, SM; Wozniak, RJ | 1 |
| Hayashi, K; Kuroda, S; Muramatsu, D; Sakai, A; Sasaki, K; Tanaka, N | 1 |
| Cao, L; Dunlevy, JR; Garrett, SH; Sens, DA; Sens, MA; Somji, S; Zheng, Y; Zhou, XD | 1 |
| de Thé, H; Nasr, R | 1 |
| Kurokawa, M; Nagai, S; Takahashi, T | 1 |
| Qu, W; Tokar, EJ; Waalkes, MP | 1 |
| Beezhold, K; Castranova, V; Chen, F; Kan, H; Liu, J; Meighan, T; Shi, X | 1 |
| Chen, C; Edin, ML; Gong, W; Li, Y; Liu, L; Wang, DW; Zeldin, DC | 1 |
| Arnold, SM; Budhraja, A; Cheng, S; Li, L; Li, W; Shelton, BJ; Shi, X; Son, YO; Sun, L; Tucker, T; Wang, X; Yao, H; Zhang, Z | 1 |
| Byers, LA; Carter, B; Chiang, CM; Girard, L; Heymach, JV; Konstantinidou, G; Rabellino, A; Rimessi, A; Scaglioni, PP; Teruya-Feldstein, J; Wu, SY | 1 |
| Chen, SJ; Chen, Z; Li, JM; Mi, JQ; Shen, ZX | 1 |
| Barnett, JB; Davis, ME; Holaskova, I; Jiang, BH; Lu, Y; Rojanasakul, Y; Schafer, R; Stueckle, TA; Wang, L | 1 |
| Bode, AM; Dong, Z; Kim, DJ; Kim, HG; Lee, KY; Li, S; Li, X | 1 |
| Shih, HM; Yang, WC | 1 |
| Hock, JM; Li, X; Liu, Y; Van Beneden, RJ | 1 |
| Garrett, SH; Gurel, V; Park, S; Sens, DA; Sens, MA; Somji, S | 1 |
| Barrett, JC; Ochi, T; Suzuki, T; Tsutsui, T | 1 |
| Ando, M; Jinno, H; Sakimoto, K; Tanaka-Kagawa, T; Tokunaga, H; Tsuchiya, T; Umeda, M | 1 |
| Beal, N; Diehl, LF; Huff, CA; Jones, RJ; Matsui, W; Smith, BD; Vala, M | 1 |
| Gogvadze, V; McConkey, DJ; Mirnikjoo, B; Nutt, LK; Orrenius, S; Uthaisang, W | 1 |
| Chen, GQ; Huang, Y; Jiang, Y; Liu, W; Peng, ZG; Song, LP; Zhao, Q | 1 |
| Horváth, V; Ondrousková, E; Smarda, J; Soucek, K | 1 |
| Eblin, KE; Futscher, BW; Gandolfi, AJ; Jensen, TJ; Novak, P | 1 |
| Bredfeldt, TG; Eblin, KE; Gandolfi, AJ | 1 |
| Dominok, B; Geppert, H | 1 |
| Chen, G; Shi, G; Tang, W | 1 |
| Ikeda, Y; Kinjo, K; Kizaki, M; Muto, A; Ueno, H | 1 |
| Hamadeh, HK; Lee, E; Menzel, DB; Vargas, M | 1 |
| Zhang, T | 1 |
| Chen, L; Jiang, S; Liang, Y | 1 |
| Bode, AM; Dong, Z | 2 |
| Krause, H | 1 |
| Fischbach, M; Gallorini, M; Pietra, R; Piette, JL; Pozzi, G; Sabbioni, E | 1 |
| Baffes, T; Dakin, A; Galt, RM; Haefliger, R; Knock, FE; Oester, YT; Renaud, OV; Rubnitz, M; Sylvester, R; Thomson, B | 1 |
| Fang, X; Gao, L; Guo, T; Hu, Y; Li, Y; Liu, Y; Pi, J; Ruan, Y; Wang, X; Xu, Y | 1 |
| Almutairy, B; Bi, Z; Chen, F; Fu, Y; Li, L; Qiu, Y; Seno, A; Thakur, C; Wadgaonkar, P; Zhang, W | 1 |
| Almutairy, B; Bi, Z; Chen, F; Fu, Y; Qiu, Y; Thakur, C; Wadgaonkar, P; Zhang, W | 1 |
| An, Y; Deng, H; Jin, T; Kato, K; Li, C; Mo, Y; Wang, X; Xia, H; Yan, R; Yang, Q; Zhang, H; Zhang, J | 1 |
| Adam, RM; Chandrasekaran, B; Damodaran, C; Navin, AK; Saran, U; Shukla, V; Tyagi, A | 1 |
| Almutairy, BS; Bi, Z; Chen, F; Fu, Y; Ji, H; Pawar, AS; Qiu, Y; Seno, A; Thakur, C; Wang, Z; Zhang, W | 1 |
| Berindan-Neagoe, I; Gurzau, E; Manda, G; Schitcu, V; Stavaru, C; Szedlacsek, S; Zimta, AA | 1 |
| Martínez-Pacheco, M; Rodríguez-Sastre, MA; Rojas, E; Valverde, M | 1 |
| Chen, S; Pi, J; Sun, R; Wang, F; Wang, H; Wu, X; Xu, H; Xu, Y; Yang, B; Zhao, R | 1 |
| Bhattacharjee, P; Das, A; Giri, AK | 1 |
| Almutairy, B; Bi, Z; Chang, Q; Chen, F; Fu, Y; Lu, Y; Rice, MKA; Thukar, C; Wadgaonkar, P; Xu, L; Zhang, Q; Zhang, W | 1 |
| Harkema, J; Kumagai, K; Lin, HP; Wang, Z; Xie, J; Yang, C; Yang, P | 1 |
| Abbasnezhad, A; Abd El-Ghafar, OA; Abhilash, L; Abouzid, KAM; Achberger, AM; Ackerman, S; Akhatayeva, Z; Akin, D; Al-Kaysi, RO; Alakhdar, AA; Alame, M; Aleksic Sabo, V; Alinezhadbalalami, N; Allen, JD; Alonso, JM; Alqatani, S; Alsayed, B; Álvarez Larraondo, M; Alvarez, M; Amini, SB; An, Z; Anasir, MI; Anderson, GH; Andremont, A; Andrés, S; Angel, S; Anigboro, AA; Anini, Y; Antonides, CFJ; Arafa, K; Arafa, RK; Aryal, UK; Asbaghi, O; Assefa, MK; Atyah, M; Avwioroko, OJ; Ayora-Talavera, G; Azpilikueta, A; Azyazov, VN; Ba, YF; Bachmann, KF; Badoual, J; Bae, SJ; Baek, SH; Bahrami, B; Bai, J; Baid-Agrawal, S; Bailey, MR; Baillie, JK; Balani, N; Balcar, VJ; Banica, T; Banks, L; Barb, J; Bardeen, CJ; Barrett, HE; Bartnikowski, N; Bashir, R; Battaglia, M; Bautista-Hernández, V; Becker, B; Beekman, FJ; Benidir, M; Benjelloun, M; Bentley, RF; Bergé, J; Berger, D; Bernsen, MR; Berraondo, P; Bhattacharya, R; Bhayani, SB; Bi, W; Bi, X; Bi, YL; Bi, Z; Bian, K; Biesecker, LG; Billadeau, DD; Blaszczyk, R; Blum, JL; Boachie, R; Boelte, K; Bogers, AJJC; Boileau, I; Bonduelle, C; Bonny, O; Bonsu, JM; Boos, LA; Borges-Argáez, R; Bouchard, PA; Boudot, C; Bourgeade-Delmas, S; Boutet-Robinet, E; Boyle, AJ; Branigan, D; Briones, S; Broniowska, KA; Brossas, JY; Brown, WA; Brzezinska, J; Buitron, G; Burnier, M; Bursulaya, B; Burton, PR; Bush, AA; Busuttil, RW; Cabello-Aguilar, S; Cáceres-Farfán, M; Cacheux, V; Caffrey, PJ; Cai, B; Cai, Q; Cai, S; Cai, Y; Calders, P; Cammarota, G; Campbell, DA; Cancelli, C; Cao, Q; Cao, WH; Cao, X; Capet, M; Capoluongo, E; Carey, ME; Carnero, M; Carrasco, LI; Carreno, J; Carrillo-Reyes, J; Casini, I; Cassar, M; Catalan, G; Cattamanchi, A; Cazares-Granillo, M; Celie, B; Cen, YK; Cena, H; Cerbo, RM; Ceron, E; Cetina-Montejo, L; Chaâbane-Banaoues, R; Chabanet, C; Chace-Donahue, F; Chalfun-Júnior, A; Chan-Balan, R; Chang, CS; Chen, CS; Chen, D; Chen, J; Chen, L; Chen, PN; Chen, Q; Chen, S; Chen, W; Chen, WP; Chen, X; Chen, Z; Cheng, H; Cheng, J; Cheng, Q; Cheng, T; Chi, T; Chianelli, D; Chieppa, M; Child, CJ; Cho, JH; Cho, JY; Chogtu, B; Choi, GH; Choi, J; Choi, M; Choi, NG; Cholu, CO; Chow, ES; Chowdhury, AH; Chu, PC; Chu, Q; Chu, S; Chua, H; Chung, T; Chunyan, L; Church, JS; Civardi, E; Cobiella, J; Colinge, J; Collado, CJ; Collins, TJ; Cong, LM; Conkrite, KL; Cope, SJ; Corbett, JA; Cornet, M; Cornillot, E; Corvaisier, S; Costes-Martineau, V; Courtioux, B; Coussens, M; Covino, M; Criado, A; Cui, J; Cui, Y; Cunitz, BW; Curry, AE; Cussó, L; D'Urzo, AD; D'Urzo, KA; Dabbous, S; Dahlgren, RA; Dai, H; Dai, T; Dai, W; Dalinghaus, M; Dang, S; Davalos, RV; Davidson, H; de Andrea, CE; De Angelis, M; de Blois, E; de Carvalho, PA; De Clercq, E; De Giuseppe, R; de Jong, M; De Langhe, S; De Oliveira, L; de Souza Pinto Lemgruber, R; de Souza, LB; de Swart, J; De Wandele, I; de Woestijne, PCV; Delaney, S; Delorme, M; Delvenne, P; Deng, L; Deng, Z; Denkinger, CM; der Meulen, MHV; Deraeve, C; Desco, M; DeSilva, S; Destere, A; Dhali, A; Di Ciano, P; Dias-Santagata, D; Diskin, SJ; Djè, MK; Doddipatla, S; Doerr, AJ; Dokla, EME; Domiciano, D; Domingo, N; Dong, C; Dong, J; Dong, Q; Dong, S; Dong, X; Dong, Z; Douair, I; Douglas, TA; Doyle, SM; Drain, PK; Du, K; Du, L; Du, Q; Du, S; Duan, C; Duan, H; Duan, J; Duan, S; Duan, W; Dueluzeau, R; Dukic, L; Dunmire, BL; Duvauchelle, T; Dymek, B; Dzwonek, K; Earnest, A; Eckardt, KU; El Ghadraoui, L; El Massoudi, S; Elloumi, F; Elnour, IE; Embarak, S; Ende, M; England, K; Enikeev, D; Enyedy, I; Epple, R; Erickson, GE; Eriksson, J; Erndt-Marino, J; Errachidi, F; Etxeberria, I; Evan, AP; Fairlamb, AH; Falahi, E; Fan, CC; Fan, H; Fan, M; Fan, MZ; Fan, S; Fan, Y; Fang, CS; Fang, J; Fang, X; Fang, Z; Farmany, A; Farooqi, A; Farouk, HO; Fazelipour, S; Feng, D; Feng, J; Feng, JX; Feng, YL; Ferraz, SL; Ferreira, CR; Figenshau, RS; Finn, AV; Fiseha, T; Fleischer, AS; Fogleman, AD; Fontaine, O; Ford, CR; Fouladvand, F; Four, M; Fousteri, G; Francis, JR; Fraser, JF; Frazier, RP; Fu, H; Fu, P; Fu, YJ; Fujishima, A; Fuster, V; Gabilan, JC; Gagliani, N; Gai, QY; Galán-Arriola, C; Gale, P; Galimova, GR; Galkin, A; Gallo, A; Gallo, AA; Gang, DD; Ganschow, S; Gao, C; Gao, F; Gao, GP; Gao, H; Gao, K; Gao, M; Gao, MY; Gao, P; Gao, R; Gao, S; Gao, WJ; Gao, Y; Garbacz, P; García Ruiz, L; Garcia, EM; Garofoli, F; Gasbarrini, A; Gattinoni, L; Gaudig, M; Gbureck, U; Ge, X; Genko, N; Gentile, GL; George, MW; Gerety, GF; Gestwicki, JE; Geusens, PP; Ghassemi, M; Giardina, JD; Giebultowicz, JM; Gifford, CA; Gijsen, FJH; Gilfillan, R; Gilson, E; Gingl, K; Giuliano, C; Glybochko, P; Goessler, W; Gofflot, S; Golab, J; Goldstein, A; Golebiowski, A; Gómez, L; Gómez-Carballo, J; Gonçalves, PEO; Gonzales, R; Gonzalez-Cotto, M; González-Fernández, D; Gonzalez-Lopez de Turiso, F; Goodman, JM; Govinda Raju, S; Grimm, J; Gross, AJ; Gruenheid, S; Gu, C; Gu, FF; Gu, S; Gu, Z; Guest, RL; Gui, C; Gui, J; Guillem, A; Guo, G; Guo, L; Guo, Q; Guo, S; Guo, SW; Guo, W; Guo, Y; Guo, YG; Guo, Z; Guretzky, JA; Haenggi, M; Hahn, MS; Hakkola, J; Halim, AA; Hampel, D; Han, B; Han, BH; Han, D; Han, G; Han, J; Han, LZ; Han, R; Han, S; Han, X; Han, Z; Handley, MA; Hanke, I; Hannongbua, S; Hao, P; Happ, JT; Hara, M; Haraux, F; Hare, JL; Harper, JD; Hartley, AM; Harvey, E; Hashimoto, K; Hassan, HM; Hautajärvi, H; Hayton, TW; He, C; He, H; He, HJ; He, WP; He, Y; He, Z; Hedrick, V; Heffernan, JK; Hegrová, J; Heidarimoghadam, R; Helms, K; Hengphasatporn, K; Henry, D; Herrmann, TRW; Hesson, T; Himmelbauer, MK; Hindle, A; Hoffmann, R; Hogg, N; Hong, KB; Hong, SK; Honjol, Y; Hood, C; Hsi, RS; Hsu, JL; Hu, B; Hu, BC; Hu, D; Hu, H; Hu, J; Hu, K; Hu, M; Hu, MK; Hu, T; Hu, W; Hu, Y; Hu, Z; Hua, S; Huang, H; Huang, J; Huang, L; Huang, M; Huang, P; Huang, X; Huang, Y; Huang, Z; Hukkanen, J; Hung, MC; Huo, X; Hyötyläinen, T; Ianiro, G; Ibanez, B; Imran, M; Ireland, S; Irwin, MS; Ishiguro, H; Jackowski, K; Jackson, C; Jacob, SI; Jahromy, MH; Jakob, SM; Jang, J; Javvaji, PK; Jefferson, KK; Jena, P; Ji, H; Jiang, F; Jiang, GH; Jiang, H; Jiang, J; Jiang, X; Jiang, Z; Jiao, J; Jiménez, A; Jin, X; Jincai, W; Jintao, X; Jo, K; Jofra, T; Johari, Y; Johnson, ACM; Jones, JH; Josephine Fauci, A; Juhl, AK; Jun, S; Kaiser, RI; Kajioka, J; Kajiyama, H; Kalliyil, A; Kalthur, SG; Kamalanathan, M; Kamaldinov, T; Kanaani, L; Kang, D; Kang, J; Kang, S; Känsäkoski, P; Kaplan, DL; Karwan, M; Kasibhatla, S; Kaur, A; Kawazoe, Y; Ke, C; Keyser, J; Khalique, A; Khan, IT; Kharshoum, RM; Kher, R; Kherani, J; Ki, KK; Kikkawa, F; Kikkawa, R; Kim, BT; Kim, EH; Kim, GA; Kim, GD; Kim, HB; Kim, HG; Kim, JS; Kim, MJ; Kim, SI; Kim, SJ; Kim, Y; King, K; Kinyamu-Akunda, J; Kirkkala, T; Kjaer-Sorensen, K; Kleppinger, EL; Kloner, RA; Klopfenstein, TJ; Knappe, D; Knezevic, P; Kobos, LM; Kohli, M; Kolano, L; Kolodgie, FD; Kolte, AP; Koneru, B; Kong, D; Kong, F; Kong, X; Konggidinata, MI; Köpke, M; Koski, KG; Kotsis, F; Köttgen, A; Kouakou-Kouamé, CA; Kraemer, US; Krane, V; Krehbiel, CR; Krenning, BJ; Kretzschmar, D; Ku, KB; Kubota, Y; Kulich, P; Kumar, NG; Kupiec-Weglinski, JW; Lalani, SS; Lan, X; Landfeldt, E; Langenberg, E; Lapauw, B; Larkin, J; Lassoued, MA; Laukhtina, E; Laura Martinez, J; Laveillé, A; Lavela, P; Law, AD; Lazraq, A; Le Foll, B; Lee, BK; Lee, C; Lee, CS; Lee, EJ; Lee, EY; Lee, G; Lee, HY; Lee, JH; Lee, JJ; Lee, JO; Lee, JS; Lee, R; Lei, H; Lei, P; Lellouche, F; Lennerz, JK; Leong, W; Leslie, I; Lessem, E; Levin, M; Levinger, I; Li, C; Li, CW; Li, CX; Li, CY; Li, D; Li, H; Li, HM; Li, J; Li, L; Li, LM; Li, N; Li, S; Li, W; Li, X; Li, XX; Li, Y; Li, Z; Li, ZL; Li, ZX; Lian, Q; Liang, C; Liang, GH; Liang, H; Liang, J; Liang, X; Liao, CX; Liao, R; Ličbinský, R; Lim, YS; Lima, HK; Lin, JG; Lin, L; Lin, S; Lin, WP; Lin, Z; Liso, M; Liu, BX; Liu, C; Liu, H; Liu, J; Liu, M; Liu, Q; Liu, S; Liu, SF; Liu, SL; Liu, T; Liu, W; Liu, X; Liu, XB; Liu, Y; Liu, YY; Liu, Z; Liu, ZQ; Lobo, M; Loitzenbauer, M; López, F; Lopez, G; López, GJ; Lou, Z; Lu, IC; Lu, J; Lu, M; Lu, W; Lu, X; Lu, Y; Luhovyy, BL; Luna-Abanto, J; Luo, J; Luo, K; Luo, L; Luo, M; Luo, W; Luo, X; Luo, XM; Lv, Y; Lv, YQ; Lyu, HD; Lyu, J; Ma, C; Ma, G; Ma, L; Ma, Q; Ma, X; Ma, Y; Macha, SJ; MacLean, E; Mahalapbutr, P; Maina, T; Malfait, F; Malfertheiner, MV; Malzert-Fréon, A; Mansouri, E; Mao, C; Marcellin, E; Marchiori, PER; Marcotte, DJ; Maréchal, A; Maric, N; Maris, JM; Maron, L; Marti, CN; Martínez-Milla, J; Mateo, J; Mather, K; Mathison, CJN; Matthay, MA; Maxwell, CL; Mazier, D; Mazumder, D; Mazurkiewicz, M; Mazzucchelli, TG; McAuley, DF; Mccoy, K; McVicar, DW; Mebel, AM; Mech, A; Meester, EJ; Meiselbach, H; Melero, I; Ménard, G; Meng, X; Mengya, Y; Merle, G; Meunier, B; Mfarrej, B; Mi, K; Migueliz, I; Mikuška, P; Miladi, K; Miletich, R; Millar, JE; Mills, MR; Milne, R; Minute, L; Misiak, M; Mo, F; Modi, A; Mok, F; Molina, C; Mollen, CJ; Molteni, V; Montalto, M; Montet, D; Monti, MC; Moor, MB; Moravec, P; Morsiani, C; Murillo, E; Murugan, P; Muslem, R; Myers, RK; N'guessan, FK; Nabil, H; Nadal, J; Nadeem, M; Nafady, MM; Nafie, MS; Nair, HP; Nakano, R; Nance, J; Naren, N; Neil, CJ; Nelson, J; Nery, FC; Netsch, C; Nguyen, TH; Ni, L; Ni, YX; Nie, W; Nielsen, LK; Nigam, K; Nikolayev, AA; Nishiyama, M; Niu, LL; Niu, PP; Nock, BA; Noer, PR; Noll, G; Noll, S; Norenberg, JP; Nowicka, J; Nutho, B; O'Connor, M; Obonyo, NG; Ochiai, T; Ochoa, MC; Oh, BL; Oh, S; Olczak, J; Olivares, X; Ommurugan, B; Oosthuizen, MC; Operario, D; Orešič, M; Oshima, K; Otano, I; Ou, Y; Owen, TW; Oxvig, C; Pacey, V; Pai, M; Paik, H; Paiva, R; Palmieri, EM; Palpant, N; Pan, L; Pan, Q; Panahi, S; Pang, B; Pang, ZC; Pannecouque, C; Paris, L; Park, D; Park, DJ; Park, E; Park, EC; Park, IH; Park, JH; Park, JI; Park, S; Passmore, MR; Pattaranggoon, NC; Paun, M; Pedersen, S; Pedron, J; Peng, M; Peng, X; Penzhorn, BL; Pérez-Camargo, D; Perez-Maldonado, R; Pérez-Vicente, C; Pham, TD; Pickering, L; Pickersgill, NA; Pinault, E; Pinotsis, N; Plan, M; Pocino, K; Poh, CL; Pons, EDC; Popoff, MR; Porri, D; Pourmand, A; Pratviel, G; Prudente, DO; Qi, H; Qi, N; Qian, LY; Qiao, L; Qiao, Q; Qin, QP; Qiu, N; Qiu, SW; Qu, F; Quan, M; Quigg, A; Raee, E; Raibaud, P; Ramanitrahasimbola, D; Rapoport, L; Rasby, RJ; Rasoanirina, BNV; Raspini, B; Ratner, JR; Razafindrakoto, Z; Redd, MA; Ren, H; Ren, N; Rey, J; Reynolds, CP; Rich, PR; Richards, CJ; Rigol, M; Rimoldi, S; Robert, P; Rodrigues, AE; Roe, JH; Rohde, S; Rokita, JL; Roland, J; Rombaut, L; Ronkainen, J; Rothenberg, SM; Roy, SC; Ruan, Z; Rucker, PV; Rueda, D; Ruhwald, M; Rungrotmongkol, T; Rupert, AS; Rusjan, P; Ryabov, AD; Rysä, J; Saad, NES; Sabioni, P; Sadow, PM; Sahai, N; Salem, HF; Salinas, B; Salonurmi, T; Samé Guerra, D; Sánchez, J; Sanchez-González, J; Sanmamed, MF; Sansores-Peraza, P; Santoro, JC; Santschi, PH; Saritas, T; Sarkisova, Y; Savolainen, MJ; Scherberich, JE; Schlom, DG; Schmelz, EM; Schmid, MC; Schneider, MP; Schumacher, S; Schwartz, JC; Schwartzer, JJ; Schwehr, K; Schweitzer, DH; Scott, ME; Sedky, NK; See Hoe, L; Sejian, V; Selvaraju, S; Sen, SK; Seo, G; Šerý, O; Settles, JA; Sfar, S; Shaffer, J; Shan, GL; Shang, Q; Shannahan, JH; Shao, B; Shao, H; Shao, J; Shao, ZH; Shasha, Y; Shaw, K; Sheeba, V; Shekar, K; Shen, G; Shen, H; Shen, XD; Shen, Y; Sherrell, PC; Shete, PB; Shi, AX; Shi, J; Shi, JH; Shi, S; Shi, X; Shigeta, Y; Shimbo, A; Shin, E; Sikka, N; Silhavy, TJ; Simanon, N; Simard, S; Simon, J; Simon, M; Simpson, SD; Simundic, AM; Since, M; Singh, B; Singhroy, DN; Sinisterra, OT; Smith, EH; Sobreira, TJP; Solanes, N; Somasundar, Y; Sommerer, C; Sonei, A; Song, B; Song, E; Song, J; Song, M; Song, Y; Soo Lee, M; Sorensen, MD; Sournia-Saquet, A; Spaepen, E; Spirk, D; Srivastava, S; Stancill, JS; Stanczak, PS; Starenki, D; Starr, F; Step, DL; Steubl, D; Stigliani, JL; Stráská, J; Sträter, N; Su, ZZ; Sudano, I; Suen, JY; Suh, HJ; Sui, ZY; Suico, JG; Suleiman, K; Sumon, K; Sun, HB; Sun, J; Sun, L; Sun, LL; Sun, M; Sun, Q; Sun, W; Sun, X; Sun, XF; Sun, Y; Sun, YB; Sun, YH; Sun, YN; Sun, Z; Sunada, K; Suzuki, S; Sylvan, JB; Takala, J; Talla, D; Tamir, Z; Tan, SJ; Tanda, S; Tang, H; Tang, J; Tang, LF; Tang, SJ; Tang, Y; Tao, FB; Tappel, R; 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29 review(s) available for arsenic and Cell Transformation, Neoplastic
| Article | Year |
|---|---|
Synergy against PML-RARa: targeting transcription, proteolysis, differentiation, and self-renewal in acute promyelocytic leukemia.
Topics: Animals; Arsenic Trioxide; Arsenicals; Cell Differentiation; Cell Line, Tumor; Cell Transformation, Neoplastic; Gene Expression Regulation, Leukemic; Humans; Leukemia, Promyelocytic, Acute; Mice; Oncogene Proteins, Fusion; Oxides; Remission Induction; Signal Transduction; Transcriptional Activation; Tretinoin | 2013 |
Understanding the molecular pathogenesis of acute promyelocytic leukemia.
Topics: Animals; Antineoplastic Agents; Arsenic Trioxide; Arsenicals; Cell Differentiation; Cell Transformation, Neoplastic; Chromosomes, Human, Pair 15; Chromosomes, Human, Pair 17; Clinical Trials as Topic; Disease Models, Animal; DNA End-Joining Repair; Drug Synergism; Granulocyte Precursor Cells; Humans; Leukemia, Promyelocytic, Acute; Mice; Molecular Targeted Therapy; Neoplasm Proteins; Neoplasms, Second Primary; Neoplastic Stem Cells; Oncogene Proteins, Fusion; Oxides; Signal Transduction; Topoisomerase II Inhibitors; Translocation, Genetic; Tretinoin | 2014 |
Molecular insight of arsenic-induced carcinogenesis and its prevention.
Topics: Animals; Anticarcinogenic Agents; Antioxidants; Apoptosis; Arsenicals; Cell Transformation, Neoplastic; Chelating Agents; Dietary Supplements; DNA Damage; Environmental Exposure; Environmental Pollutants; Food Contamination; Humans; Mutation; Neoplasms; Oxidative Stress; Risk Assessment; Risk Factors; Water Pollutants, Chemical; Water Supply | 2017 |
The impact of molecularly targeted therapies upon the understanding of leukemogenesis and the role of hematopoietic stem cell transplantation in acute promyelocytic leukemia.
Topics: Animals; Apoptosis; Arsenic Trioxide; Arsenicals; Cell Differentiation; Cell Survival; Cell Transformation, Neoplastic; Glutamates; Hematopoietic Stem Cell Transplantation; Humans; Leukemia, Promyelocytic, Acute; Myeloid Progenitor Cells; Neoplastic Stem Cells; Nuclear Proteins; Oxides; Prodrugs; Promyelocytic Leukemia Protein; Transcription Factors; Tretinoin; Tumor Suppressor Proteins | 2010 |
How to manage acute promyelocytic leukemia.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Arsenic Trioxide; Arsenicals; Cell Transformation, Neoplastic; Central Nervous System Neoplasms; Consolidation Chemotherapy; Drug Synergism; Humans; Induction Chemotherapy; Leukemia, Promyelocytic, Acute; Maintenance Chemotherapy; Oxides; Recurrence; Tretinoin | 2012 |
Hypoxia inducible factor-1alpha and leukemic cell differentiation.
Topics: Animals; Antineoplastic Agents; Arsenic Trioxide; Arsenicals; Cell Transformation, Neoplastic; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Leukemia; Leukemia, Promyelocytic, Acute; Oxides | 2006 |
Immortalized human urothelial cells as a model of arsenic-induced bladder cancer.
Topics: Animals; Arsenicals; Carcinogens; Carcinoma, Transitional Cell; Cell Line, Transformed; Cell Transformation, Neoplastic; Humans; Models, Biological; Urinary Bladder Neoplasms; Urothelium | 2008 |
The paradox of arsenic: molecular mechanisms of cell transformation and chemotherapeutic effects.
Topics: Animals; Antineoplastic Agents; Apoptosis; Arsenic; Arsenicals; Cell Transformation, Neoplastic; Glutathione; Humans; MAP Kinase Signaling System; Mice; Neoplasms; Neoplasms, Experimental; NF-kappa B; Transcription Factor AP-1; Transcription, Genetic | 2002 |
Metabolic reprogramming in the arsenic carcinogenesis.
Topics: Arsenic; Carcinogenesis; Cell Transformation, Neoplastic; Glycolysis; Humans; Neoplasms; Tumor Microenvironment | 2022 |
Tumor suppressive activity of AHR in environmental arsenic-induced carcinogenesis.
Topics: Arsenic; Carcinogenesis; Cell Transformation, Neoplastic; Humans; NF-E2-Related Factor 2; Receptors, Aryl Hydrocarbon | 2023 |
Biological and molecular modifications induced by cadmium and arsenic during breast and prostate cancer development.
Topics: Arsenic; Breast Neoplasms; Cadmium; Cell Transformation, Neoplastic; Environmental Exposure; Environmental Pollutants; Humans; Male; Metals, Heavy; Prostatic Neoplasms | 2019 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor Proteins, Signal Transducing; Adenine; Adenocarcinoma; Adipogenesis; Administration, Cutaneous; Administration, Ophthalmic; Adolescent; Adsorption; Adult; Aeromonas hydrophila; Aerosols; Aged; Aged, 80 and over; Aging; Agriculture; Air Pollutants; Air Pollution; Airway Remodeling; Alanine Transaminase; Albuminuria; Aldehyde Dehydrogenase 1 Family; Algorithms; AlkB Homolog 2, Alpha-Ketoglutarate-Dependent Dioxygenase; Alzheimer Disease; Amino Acid Sequence; Ammonia; Ammonium Compounds; Anaerobiosis; Anesthetics, Dissociative; Anesthetics, Inhalation; Animals; Anti-Bacterial Agents; Anti-HIV Agents; Anti-Infective Agents; Anti-Inflammatory Agents; Antibiotics, Antineoplastic; Antibodies, Antineutrophil Cytoplasmic; Antibodies, Monoclonal, Humanized; Antifungal Agents; Antigens, Bacterial; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Antioxidants; Antitubercular Agents; Antiviral Agents; Apolipoproteins E; Apoptosis; Arabidopsis; Arabidopsis Proteins; Arsenic; Arthritis, Rheumatoid; Asthma; Atherosclerosis; ATP-Dependent Proteases; Attitude of Health Personnel; Australia; Austria; Autophagy; Axitinib; Bacteria; Bacterial Outer Membrane Proteins; Bacterial Proteins; Bacterial Toxins; Bacterial Typing Techniques; Bariatric Surgery; Base Composition; Bayes Theorem; Benzoxazoles; Benzylamines; beta Catenin; Betacoronavirus; Betula; Binding Sites; Biological Availability; Biological Oxygen Demand Analysis; Biomarkers; Biomarkers, Tumor; Biopsy; Bioreactors; Biosensing Techniques; Birth Weight; Blindness; Blood Chemical Analysis; Blood Gas Analysis; Blood Glucose; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Blood-Brain Barrier; Blotting, Western; Body Mass Index; Body Weight; Bone and Bones; Bone Density; Bone Resorption; Borates; Brain; Brain Infarction; Brain Injuries, Traumatic; Brain Neoplasms; Breakfast; Breast Milk Expression; Breast Neoplasms; Bronchi; Bronchoalveolar Lavage Fluid; Buffaloes; Cadherins; Calcification, Physiologic; Calcium Compounds; Calcium, Dietary; Cannula; Caprolactam; Carbon; Carbon Dioxide; Carboplatin; Carcinogenesis; Carcinoma, Ductal; Carcinoma, Ehrlich Tumor; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Carcinoma, Pancreatic Ductal; Carcinoma, Renal Cell; Cardiovascular Diseases; Carps; Carrageenan; Case-Control Studies; Catalysis; Catalytic Domain; Cattle; CD8-Positive T-Lymphocytes; Cell Adhesion; Cell Cycle Proteins; Cell Death; Cell Differentiation; Cell Line; Cell Line, Tumor; Cell Movement; Cell Nucleus; Cell Phone Use; Cell Proliferation; Cell Survival; Cell Transformation, Neoplastic; Cell Transformation, Viral; Cells, Cultured; Cellulose; Chemical Phenomena; Chemoradiotherapy; Child; Child Development; Child, Preschool; China; Chitosan; Chlorocebus aethiops; Cholecalciferol; Chromatography, Liquid; Circadian Clocks; 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Risk Factors; Ritonavir; Rivers; RNA Interference; RNA-Seq; RNA, Messenger; RNA, Ribosomal, 16S; RNA, Small Interfering; Rosuvastatin Calcium; Rural Population; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Salivary Ducts; Salivary Gland Neoplasms; San Francisco; SARS-CoV-2; Satiation; Satiety Response; Schools; Schools, Pharmacy; Seasons; Seawater; Selection, Genetic; Sequence Analysis, DNA; Serine-Threonine Kinase 3; Sewage; Sheep; Sheep, Domestic; Shock, Hemorrhagic; Signal Transduction; Silver; Silymarin; Single Photon Emission Computed Tomography Computed Tomography; Sirolimus; Sirtuin 1; Skin; Skin Neoplasms; Skin Physiological Phenomena; Sleep Initiation and Maintenance Disorders; Social Class; Social Participation; Social Support; Soil; Soil Microbiology; Solutions; Somatomedins; Soot; Specimen Handling; Spectrophotometry, Ultraviolet; Spectroscopy, Fourier Transform Infrared; Spectrum Analysis; Spinal Fractures; Spirometry; Staphylococcus aureus; STAT1 Transcription Factor; STAT3 Transcription Factor; Streptomyces coelicolor; Stress, Psychological; Stroke; Stroke Volume; Structure-Activity Relationship; Students, Medical; Students, Pharmacy; Substance Abuse Treatment Centers; Sulfur Dioxide; Surface Properties; Surface-Active Agents; Surveys and Questionnaires; Survival Analysis; Survival Rate; Survivin; Sweden; Swine; Swine, Miniature; Sympathetic Nervous System; T-Lymphocytes, Regulatory; Talaromyces; Tandem Mass Spectrometry; tau Proteins; Telemedicine; Telomerase; Telomere; Telomere Homeostasis; Temperature; Terminally Ill; Th1 Cells; Thiamethoxam; Thiazoles; Thiophenes; Thioredoxin Reductase 1; Thrombosis; Thulium; Thyroid Cancer, Papillary; Thyroid Carcinoma, Anaplastic; Thyroid Neoplasms; Time Factors; Titanium; Tomography, Emission-Computed, Single-Photon; Tomography, X-Ray Computed; TOR Serine-Threonine Kinases; Transcription Factor AP-1; Transcription Factors; Transcription, Genetic; Transcriptional Activation; Transcriptome; Transforming Growth Factor beta1; Transistors, Electronic; Translational Research, Biomedical; Transplantation Tolerance; Transplantation, Homologous; Transportation; Treatment Outcome; Tretinoin; Tuberculosis, Multidrug-Resistant; Tuberculosis, Pulmonary; Tubulin Modulators; Tumor Microenvironment; Tumor Necrosis Factor Inhibitors; Tumor Necrosis Factor-alpha; Twins; Ultrasonic Therapy; Ultrasonography; Ultraviolet Rays; United States; Up-Regulation; Uranium; Urethra; Urinary Bladder; Urodynamics; Uromodulin; Uveitis; Vasoconstrictor Agents; Ventricular Function, Left; Vero Cells; Vesicular Transport Proteins; Viral Nonstructural Proteins; Visual Acuity; Vital Capacity; Vitamin D; Vitamin D Deficiency; Vitamin K 2; Vitamins; Volatilization; Voriconazole; Waiting Lists; Waste Disposal, Fluid; Wastewater; Water Pollutants, Chemical; Whole Genome Sequencing; Wine; Wnt Signaling Pathway; Wound Healing; Wounds and Injuries; WW Domains; X-linked Nuclear Protein; X-Ray Diffraction; Xanthines; Xenograft Model Antitumor Assays; YAP-Signaling Proteins; Yogurt; Young Adult; Zebrafish; Zebrafish Proteins; Ziziphus | 2016 |
Cooperation between NRF2-mediated transcription and MDIG-dependent epigenetic modifications in arsenic-induced carcinogenesis and cancer stem cells.
Topics: Animals; Arsenic; Cell Transformation, Neoplastic; Dioxygenases; Epigenesis, Genetic; Histone Demethylases; Humans; Neoplastic Stem Cells; NF-E2-Related Factor 2; Nuclear Proteins; Transcription, Genetic | 2021 |
A comprehensive review of metal-induced cellular transformation studies.
Topics: Animals; Apoptosis; Arsenic; Carcinogens; Cell Line, Transformed; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; Humans; Metals; Nickel | 2017 |
Arsenic toxicity and epimutagenecity: the new LINEage.
Topics: Arsenic; Arsenic Poisoning; Cell Transformation, Neoplastic; CpG Islands; DNA Methylation; Environmental Exposure; Epigenesis, Genetic; Folic Acid; Genome, Human; Humans; Long Interspersed Nucleotide Elements; Neoplasms; Promoter Regions, Genetic; S-Adenosylmethionine | 2017 |
Arsenic-Induced Carcinogenesis: The Impact of miRNA Dysregulation.
Topics: Arsenic; Carcinogenesis; Cell Transformation, Neoplastic; Epigenesis, Genetic; Humans; MicroRNAs; Neoplasms; Water Pollutants, Chemical | 2018 |
Metabolic and epigenetic reprogramming in the arsenic-induced cancer stem cells.
Topics: Animals; Arsenic; Autophagy; Cell Transformation, Neoplastic; Cellular Reprogramming; Disease Susceptibility; Endoplasmic Reticulum Stress; Energy Metabolism; Epigenesis, Genetic; Gene Expression Regulation; Humans; Metabolic Networks and Pathways; Mitochondria; Neoplasms; Neoplastic Stem Cells; Signal Transduction | 2019 |
Metal-induced carcinogenesis, oxidative stress and hypoxia signalling.
Topics: Animals; Arsenic; Carcinogens, Environmental; Cell Hypoxia; Cell Transformation, Neoplastic; Humans; Metals, Heavy; Models, Biological; Oxidative Stress; Reactive Oxygen Species; Signal Transduction | 2009 |
Epigenetics in metal carcinogenesis: nickel, arsenic, chromium and cadmium.
Topics: Animals; Arsenic; Arsenic Poisoning; Cell Transformation, Neoplastic; DNA Methylation; Epigenomics; Gene Expression Regulation, Neoplastic; Heavy Metal Poisoning; Humans; Metals, Heavy | 2009 |
The role of biomethylation in toxicity and carcinogenicity of arsenic: a research update.
Topics: Animals; Arsenic; Biotransformation; Cell Line; Cell Transformation, Neoplastic; Humans; Mammals; Methylation; Methyltransferases; Transcription, Genetic | 2002 |
Arsenic-mediated cellular signal transduction, transcription factor activation, and aberrant gene expression: implications in carcinogenesis.
Topics: Arsenic; Cell Transformation, Neoplastic; DNA-Binding Proteins; Environmental Pollutants; Gene Expression Regulation, Neoplastic; Humans; Mitogen-Activated Protein Kinases; NF-kappa B; Replication Protein C; Signal Transduction | 2002 |
Arsenic toxicity, mutagenesis, and carcinogenesis--a health risk assessment and management approach.
Topics: Arsenic; Arsenic Poisoning; Carcinogens, Environmental; Cell Transformation, Neoplastic; Environmental Exposure; Environmental Health; Environmental Monitoring; Humans; Mutagenesis; Primary Prevention; Risk Assessment; Skin Neoplasms; Water Pollutants, Chemical | 2004 |
Oxidative mechanism of arsenic toxicity and carcinogenesis.
Topics: Animals; Antioxidants; Arsenic; Cattle; Cell Transformation, Neoplastic; Cricetinae; DNA Damage; Free Radical Scavengers; Free Radicals; Gene Expression Regulation, Neoplastic; Humans; Lipid Peroxidation; Mice; Neoplasms; Oxidative Stress; Rats; Reactive Oxygen Species; Tumor Suppressor Protein p53 | 2004 |
Molecular mechanisms of arsenic carcinogenesis.
Topics: Animals; Arsenic; Cell Transformation, Neoplastic; Cricetinae; Cytokines; DNA Damage; DNA Repair; Environmental Pollutants; Gene Expression Regulation, Neoplastic; Humans; Mice; Mutagens; Oncogenes; Oxidative Stress; Protein Kinases; Rabbits; Rats; Reactive Oxygen Species; Signal Transduction; Transcription Factors | 2004 |
Signal transduction pathways in cancer development and as targets for cancer prevention.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticarcinogenic Agents; Antineoplastic Agents; Apoptosis; Arsenic; Cell Transformation, Neoplastic; Disease Models, Animal; Drug Design; Histones; Humans; JNK Mitogen-Activated Protein Kinases; Mice; Neoplasms; Phosphorylation; Protein Kinase C; Signal Transduction; Transcription Factors; Ultraviolet Rays | 2005 |
Effects of metals in in vitro bioassays.
Topics: Animals; Arsenic; Biological Assay; Cell Transformation, Neoplastic; Cell Transformation, Viral; Chromium; Chromosome Aberrations; Cricetinae; Humans; Mesocricetus; Metals; Mutagenicity Tests; Neoplasms; Platinum; Selenium | 1981 |
Retinoic acid and arsenic: towards oncogene-targeted treatments of acute promyelocytic leukaemia.
Topics: Animals; Arsenic; Artificial Gene Fusion; Cell Transformation, Neoplastic; Humans; Leukemia, Promyelocytic, Acute; Neoplasm Proteins; Nuclear Proteins; Promyelocytic Leukemia Protein; Receptors, Retinoic Acid; Retinoic Acid Receptor alpha; Transcription Factors; Translocation, Genetic; Tretinoin; Tumor Suppressor Proteins | 1997 |
[Occupational chemical pollution and cancer].
Topics: Acrylonitrile; Animals; Arsenic; Asbestosis; Belgium; Benzene Derivatives; Biotransformation; Cadmium; Carcinogens; Cell Transformation, Neoplastic; Chemical Industry; Epoxy Compounds; Humans; Hydrocarbons, Halogenated; Mice; Mining; Neoplasms; Nickel; Nitroso Compounds; Occupational Diseases; Textile Industry; United States | 1979 |
Trace metals and neoplasia.
Topics: Animals; Arsenic; Beryllium; Cadmium; Carcinogens; Cell Transformation, Neoplastic; Chromium; Chromosome Aberrations; DNA; DNA Polymerase I; Environmental Exposure; Gastrointestinal Neoplasms; Humans; In Vitro Techniques; Neoplasms; Neoplasms, Experimental; Nickel; Occupational Diseases; Respiratory Tract Neoplasms; Selenium; Trace Elements | 1986 |
1 trial(s) available for arsenic and Cell Transformation, Neoplastic
145 other study(ies) available for arsenic and Cell Transformation, Neoplastic
| Article | Year |
|---|---|
DNA methylation of a non-CpG island promoter represses NQO1 expression in rat arsenic-transformed lung epithelial cells.
Topics: Animals; Arsenic Trioxide; Arsenicals; Azacitidine; Cell Line, Transformed; Cell Transformation, Neoplastic; CpG Islands; Decitabine; DNA Methylation; Enzyme Inhibitors; Epithelial Cells; Gene Expression Regulation; Lung; NAD(P)H Dehydrogenase (Quinone); Oxides; Promoter Regions, Genetic; Rats | 2018 |
Enhanced cell growth and tumorigenicity of rat glioma cells by stable expression of human CD133 through multiple molecular actions.
Topics: AC133 Antigen; Animals; Antigens, CD; Antineoplastic Agents; Arsenic Trioxide; Arsenicals; Basic Helix-Loop-Helix Transcription Factors; Brain Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Transformation, Neoplastic; Cerebral Cortex; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Formazans; Gene Expression Regulation, Neoplastic; Glioma; Glycoproteins; GTPase-Activating Proteins; Homeodomain Proteins; Humans; Intercellular Signaling Peptides and Proteins; Lentivirus; Oncogene Protein v-akt; Oxides; Peptides; Rats; Rats, Sprague-Dawley; Receptor, Notch1; RNA, Messenger; RNA, Small Interfering; Tetrazolium Salts; Time Factors; Transcription Factor HES-1; Transfection; Tumor Stem Cell Assay | 2013 |
Effective targeting of chronic myeloid leukemia initiating activity with the combination of arsenic trioxide and interferon alpha.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Antiviral Agents; Apoptosis; Arsenic Trioxide; Arsenicals; Benzamides; Bone Marrow Transplantation; Cell Transformation, Neoplastic; Humans; Imatinib Mesylate; Interferon-alpha; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Mice; Mice, Inbred BALB C; Oxides; Piperazines; Prognosis; Pyrimidines; Real-Time Polymerase Chain Reaction; Survival Rate; Tumor Cells, Cultured; Tumor Stem Cell Assay | 2014 |
Methylarsonous acid causes oxidative DNA damage in cells independent of the ability to biomethylate inorganic arsenic.
Topics: Adaptation, Physiological; Animals; Arsenic Poisoning; Arsenicals; Cell Line; Cell Transformation, Neoplastic; DNA Damage; Humans; Liver; Male; Methylation; Multidrug Resistance-Associated Protein 2; Oxidation-Reduction; Prostate; PTEN Phosphohydrolase; Rats; Toxicity Tests, Chronic | 2014 |
The acute promyelocytic leukaemia success story: curing leukaemia through targeted therapies.
Topics: Antineoplastic Combined Chemotherapy Protocols; Arsenic Trioxide; Arsenicals; Cell Transformation, Neoplastic; Epigenesis, Genetic; Humans; Leukemia, Promyelocytic, Acute; Molecular Targeted Therapy; Oxides; Receptors, Cytoplasmic and Nuclear; Receptors, Retinoic Acid; Retinoic Acid Receptor alpha; Retinoid X Receptor alpha; Signal Transduction; Tretinoin | 2014 |
Clearance of PML/RARA-bound promoters suffice to initiate APL differentiation.
Topics: Animals; Antineoplastic Agents; Arsenic Trioxide; Arsenicals; Cell Differentiation; Cell Line, Tumor; Cell Transformation, Neoplastic; Cells, Cultured; Chlorocebus aethiops; COS Cells; Gene Expression Profiling; Humans; Leukemia, Promyelocytic, Acute; Mice, Inbred C57BL; Mice, Inbred Strains; Mice, Nude; Mice, Transgenic; Oncogene Proteins, Fusion; Oxides; Promoter Regions, Genetic; Protein Binding; Retinoid X Receptor alpha; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Sumoylation; Transcriptional Activation; Tretinoin | 2014 |
TG-interacting factor mediates arsenic-induced malignant transformation of keratinocytes via c-Src/EGFR/AKT/FOXO3A and redox signalings.
Topics: Animals; Arsenic Trioxide; Arsenicals; Cell Line; Cell Transformation, Neoplastic; CSK Tyrosine-Protein Kinase; Dose-Response Relationship, Drug; ErbB Receptors; Forkhead Box Protein O3; Forkhead Transcription Factors; Gene Knockdown Techniques; Homeodomain Proteins; Humans; Keratinocytes; Mice; NIH 3T3 Cells; Oxidation-Reduction; Oxides; Proto-Oncogene Proteins c-akt; Repressor Proteins; Signal Transduction; src-Family Kinases | 2015 |
Analysis of the transcriptional regulation of cancer-related genes by aberrant DNA methylation of the cis-regulation sites in the promoter region during hepatocyte carcinogenesis caused by arsenic.
Topics: Amino Acid Motifs; Arsenic Trioxide; Arsenicals; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; Carcinogenesis; Cell Line; Cell Transformation, Neoplastic; Computational Biology; DNA Methylation; Gene Expression Regulation, Neoplastic; Hepatocytes; Humans; Liver; Liver Neoplasms; Oligonucleotide Array Sequence Analysis; Oxides; Promoter Regions, Genetic; RNA, Messenger; Signal Transduction; Transcription Factors; Transcriptional Activation; Wnt Proteins | 2015 |
Dimethylarsine likely acts as a mouse-pulmonary tumor initiator via the production of dimethylarsine radical and/or its peroxy radical.
Topics: Animals; Arsenicals; Carcinogens; Cell Transformation, Neoplastic; Glutathione Reductase; Lung; Lung Neoplasms; Male; Mice; Peroxides; Rats | 2009 |
Realgar-induced differentiation is associated with MAPK pathways in HL-60 cells.
Topics: Antineoplastic Agents; Arsenicals; CD11 Antigens; Cell Differentiation; Cell Transformation, Neoplastic; HL-60 Cells; Humans; JNK Mitogen-Activated Protein Kinases; Leukemia, Promyelocytic, Acute; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 3; Nanoparticles; p38 Mitogen-Activated Protein Kinases; RNA, Messenger; Sulfides | 2008 |
Antitumor effects of arsenic trioxide in transformed human thyroid cells.
Topics: Adenocarcinoma, Follicular; Antineoplastic Agents; Apoptosis; Arsenic Trioxide; Arsenicals; Biological Transport, Active; Carcinoma, Papillary; Cell Differentiation; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; Glucose; Glutathione; Humans; Iodides; Iodine Radioisotopes; Oncogene Protein v-akt; Oxides; Phosphatidylinositol 3-Kinases; Radiation Tolerance; Reactive Oxygen Species; Thyroid Neoplasms | 2008 |
Epigenetic mediated transcriptional activation of WNT5A participates in arsenical-associated malignant transformation.
Topics: Arsenicals; Carcinogens; Cell Line; Cell Transformation, Neoplastic; Epigenesis, Genetic; Gene Silencing; Histones; Humans; Mutation; Promoter Regions, Genetic; Proto-Oncogene Proteins; Transcription, Genetic; Wnt Proteins; Wnt-5a Protein | 2009 |
Comparison of sensitivity to arsenic compounds between a Bhas 42 cell transformation assay and a BALB/c 3T3 cell transformation assay.
Topics: Animals; Arsenates; Arsenicals; Arsenites; BALB 3T3 Cells; Cacodylic Acid; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; Dose-Response Relationship, Drug; Mice | 2009 |
Arsenic and prostate cancer.
Topics: Arsenicals; Biomarkers; Cell Transformation, Neoplastic; Environmental Exposure; Erectile Dysfunction; Humans; Male; Prostate; Prostatic Neoplasms; United States; Water Pollution, Chemical; Water Supply | 2009 |
Keratin 6 expression correlates to areas of squamous differentiation in multiple independent isolates of As(+3)-induced bladder cancer.
Topics: Animals; Arsenic Trioxide; Arsenicals; Biomarkers, Tumor; Carcinogens; Carcinoma, Transitional Cell; Cell Line, Transformed; Cell Line, Tumor; Cell Transformation, Neoplastic; Gene Expression Regulation, Neoplastic; Humans; Keratin-6; Mice; Mice, Nude; Neoplasm Transplantation; Oxides; Urinary Bladder Neoplasms; Urothelium | 2010 |
Eradication of acute promyelocytic leukemia-initiating cells by PML/RARA-targeting.
Topics: Animals; Antineoplastic Agents; Arsenic Trioxide; Arsenicals; Cell Transformation, Neoplastic; Gene Expression Regulation, Neoplastic; Granulocyte Precursor Cells; Humans; Leukemia, Promyelocytic, Acute; Mice; Oncogene Proteins, Fusion; Oncogenes; Oxides; Tretinoin | 2010 |
Arsenic, stem cells, and the developmental basis of adult cancer.
Topics: Animals; Arsenic Poisoning; Arsenicals; Carcinogenicity Tests; Carcinogens, Environmental; Cell Transformation, Neoplastic; Epigenesis, Genetic; Female; Humans; Maternal Exposure; Maternal-Fetal Exchange; Mice; Neoplastic Stem Cells; Pregnancy; Prenatal Exposure Delayed Effects; Skin Neoplasms; Water Pollutants, Chemical | 2011 |
miR-190-mediated downregulation of PHLPP contributes to arsenic-induced Akt activation and carcinogenesis.
Topics: Arsenic Poisoning; Arsenic Trioxide; Arsenicals; Bronchi; Carcinogens, Environmental; Cell Line; Cell Proliferation; Cell Transformation, Neoplastic; Down-Regulation; Epithelial Cells; Gene Expression Regulation; Gene Silencing; Humans; MicroRNAs; Nuclear Proteins; Oxides; Phosphoprotein Phosphatases; RNA, Messenger; Talin | 2011 |
Epoxyeicosatrienoic acids attenuate reactive oxygen species level, mitochondrial dysfunction, caspase activation, and apoptosis in carcinoma cells treated with arsenic trioxide.
Topics: 8,11,14-Eicosatrienoic Acid; Antineoplastic Agents; Antioxidants; Apoptosis; Arsenic Trioxide; Arsenicals; Caspase Inhibitors; Caspases; Cell Line, Tumor; Cell Transformation, Neoplastic; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Screening Assays, Antitumor; Drug Synergism; Enzyme Activation; HEK293 Cells; Humans; Indazoles; Membrane Potential, Mitochondrial; Mitochondria; Nitrofurans; Oxides; Reactive Oxygen Species | 2011 |
Reactive oxygen species mediate arsenic induced cell transformation and tumorigenesis through Wnt/β-catenin pathway in human colorectal adenocarcinoma DLD1 cells.
Topics: Adenocarcinoma; Animals; Arsenicals; beta Catenin; Blotting, Western; Carcinogenicity Tests; Catenins; Cell Line, Tumor; Cell Transformation, Neoplastic; Colorectal Neoplasms; Electron Spin Resonance Spectroscopy; Enzyme Activation; Humans; Male; Mice; Mice, Nude; NADPH Oxidases; Reactive Oxygen Species; Signal Transduction; Wnt Proteins | 2011 |
The SUMO E3-ligase PIAS1 regulates the tumor suppressor PML and its oncogenic counterpart PML-RARA.
Topics: Animals; Arsenic Trioxide; Arsenicals; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Transformation, Neoplastic; HEK293 Cells; Humans; Lung Neoplasms; Nuclear Proteins; Oncogene Proteins, Fusion; Oxides; Polymorphism, Single Nucleotide; Promyelocytic Leukemia Protein; Protein Inhibitors of Activated STAT; Rats; Small Ubiquitin-Related Modifier Proteins; Transcription Factors; Transfection; Tumor Suppressor Proteins; Ubiquitin | 2012 |
Chronic occupational exposure to arsenic induces carcinogenic gene signaling networks and neoplastic transformation in human lung epithelial cells.
Topics: Animals; Arsenic Trioxide; Arsenicals; Cell Proliferation; Cell Transformation, Neoplastic; Cells, Cultured; Epithelial Cells; Female; Gene Regulatory Networks; Humans; Lung; Lung Neoplasms; Mice; Mitochondria; Neoplasm Invasiveness; Occupational Exposure; Oligonucleotide Array Sequence Analysis; Oxides; PPAR alpha; Signal Transduction | 2012 |
Polycomb (PcG) proteins, BMI1 and SUZ12, regulate arsenic-induced cell transformation.
Topics: 3T3 Cells; Animals; Arsenic; Arsenic Trioxide; Arsenicals; Cell Transformation, Neoplastic; Cyclin-Dependent Kinase Inhibitor p16; Gene Expression Regulation, Neoplastic; Histones; Humans; Mice; Mice, Inbred BALB C; Neoplasm Transplantation; Oxides; Polycomb Repressive Complex 1; Polycomb Repressive Complex 2; Polycomb-Group Proteins; Proto-Oncogene Proteins; Signal Transduction | 2012 |
The deubiquitinating enzyme USP37 regulates the oncogenic fusion protein PLZF/RARA stability.
Topics: Animals; Arsenic Trioxide; Arsenicals; Cell Differentiation; Cell Transformation, Neoplastic; Endopeptidases; Gene Expression Regulation, Leukemic; Humans; Leukemia, Promyelocytic, Acute; Mice; Oncogene Proteins, Fusion; Oxides; Protein Stability; Translocation, Genetic | 2013 |
Aberrant overexpression of FOXM1 transcription factor plays a critical role in lung carcinogenesis induced by low doses of arsenic.
Topics: Adenocarcinoma; Adult; Animals; Antineoplastic Agents; Apoptosis; Arsenic Trioxide; Arsenicals; Blotting, Western; Cell Proliferation; Cell Transformation, Neoplastic; Cells, Cultured; Dose-Response Relationship, Drug; Forkhead Box Protein M1; Forkhead Transcription Factors; Gene Expression Regulation; Gene Knockdown Techniques; Humans; Lung; Lung Neoplasms; Mice; Mice, SCID; Oxides; Polymorphism, Single Nucleotide; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Small Interfering | 2014 |
Inorganic cadmium- and arsenite-induced malignant transformation of human bladder urothelial cells.
Topics: Agar; Animals; Arsenicals; Cadmium Compounds; Cell Culture Techniques; Cell Division; Cell Line; Cell Transformation, Neoplastic; Dose-Response Relationship, Drug; Humans; Mice; Mice, Nude; Neoplasm Transplantation; Neoplasms, Experimental; Time Factors; Urinary Bladder; Urothelium | 2004 |
A trivalent dimethylarsenic compound, dimethylarsine iodide, induces cellular transformation, aneuploidy, centrosome abnormality and multipolar spindle formation in Syrian hamster embryo cells.
Topics: Aneuploidy; Animals; Arsenicals; Cell Division; Cell Transformation, Neoplastic; Centrosome; Cricetinae; DNA; Flow Cytometry; Fluorescent Antibody Technique; Mesocricetus; Microtubules; Precancerous Conditions; Spindle Apparatus | 2004 |
Inorganic arsenic compounds and methylated metabolites induce morphological transformation in two-stage BALB/c 3T3 cell assay and inhibit metabolic cooperation in V79 cell assay.
Topics: Animals; Arsenic Poisoning; Arsenicals; BALB 3T3 Cells; Cacodylic Acid; Carcinogens; Cell Communication; Cell Survival; Cell Transformation, Neoplastic; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Methylcholanthrene; Mice; Sulfhydryl Reagents | 2005 |
Requirement for myeloid growth factors in the differentiation of acute promyelocytic leukaemia.
Topics: Antineoplastic Agents; Apoptosis; Arsenic Trioxide; Arsenicals; Bryostatins; Cell Cycle; Cell Line, Tumor; Cell Transformation, Neoplastic; Flow Cytometry; Granulocyte Colony-Stimulating Factor; Granulocyte-Macrophage Colony-Stimulating Factor; Growth Inhibitors; Humans; Leukemia, Promyelocytic, Acute; Macrolides; Myelopoiesis; Oxides; Tretinoin | 2005 |
Indirect effects of Bax and Bak initiate the mitochondrial alterations that lead to cytochrome c release during arsenic trioxide-induced apoptosis.
Topics: Animals; Apoptosis; Arsenic Trioxide; Arsenicals; bcl-2 Homologous Antagonist-Killer Protein; bcl-2-Associated X Protein; Caspase 3; Caspases; Cell Line, Transformed; Cell Transformation, Neoplastic; Cells, Cultured; Cytochrome c Group; Dose-Response Relationship, Drug; Embryo, Mammalian; Fibroblasts; Male; Mice; Mice, Inbred BALB C; Mice, Knockout; Mitochondria, Liver; Necrosis; Oxidative Stress; Oxides; Reactive Oxygen Species; Superoxides | 2005 |
Alternative pathways of programmed cell death are activated in cells with defective caspase-dependent apoptosis.
Topics: Animals; Antineoplastic Agents; Apoptosis; Arsenic Trioxide; Arsenicals; Autophagy; Blotting, Western; Camptothecin; Caspases; Cell Line, Transformed; Cell Transformation, Neoplastic; Chickens; Cycloheximide; Genes, myb; Humans; Microscopy, Fluorescence; Necrosis; Oxides; Signal Transduction; U937 Cells | 2008 |
Epigenetic remodeling during arsenical-induced malignant transformation.
Topics: Acetylation; Arsenicals; Azacitidine; Cell Line; Cell Line, Tumor; Cell Transformation, Neoplastic; Decitabine; Environmental Exposure; Histones; Humans; Hydroxamic Acids; Lung Neoplasms; Oligonucleotide Array Sequence Analysis; Promoter Regions, Genetic; Reverse Transcriptase Polymerase Chain Reaction; Skin Neoplasms; Teratogens; Urinary Bladder Neoplasms; Urothelium | 2008 |
[Dynamics of nickel in the cell].
Topics: Animals; Arsenicals; Cell Transformation, Neoplastic; Humans; Mitosis; Nickel | 1984 |
[Double effects of arsenic trioxide (As2O3) on acute promyelocytic leukemic cell line].
Topics: Antineoplastic Agents; Apoptosis; Arsenic Trioxide; Arsenicals; Cell Transformation, Neoplastic; Humans; Leukemia, Promyelocytic, Acute; Oncogene Proteins, Fusion; Oxides; Tumor Cells, Cultured | 1997 |
Application of heavy metal and cytokine for differentiation-inducing therapy in acute promyelocytic leukemia.
Topics: Antineoplastic Agents; Apoptosis; Arsenic Trioxide; Arsenicals; Cell Differentiation; Cell Transformation, Neoplastic; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Leukemia, Promyelocytic, Acute; Oxides; Tretinoin; Tumor Cells, Cultured | 1998 |
Arsenic disrupts cellular levels of p53 and mdm2: a potential mechanism of carcinogenesis.
Topics: Arsenates; Arsenic; Arsenic Poisoning; Arsenicals; Arsenites; Cell Line; Cell Transformation, Neoplastic; Humans; Keratinocytes; Nuclear Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-mdm2; Teratogens; Tumor Suppressor Protein p53 | 1999 |
[Cell differentiation and apoptosis of tumor cells].
Topics: Antineoplastic Agents; Apoptosis; Arsenic Trioxide; Arsenicals; Cell Transformation, Neoplastic; Humans; Leukemia, Promyelocytic, Acute; Oxides | 1999 |
[Affect of As(2)O(3) on the sister chromatid exchanges in human blood lymphocytes].
Topics: Arsenicals; Carcinogens; Cell Cycle; Cell Proliferation; Cell Transformation, Neoplastic; Cells, Cultured; Dose-Response Relationship, Drug; Humans; Lymphocytes; Sister Chromatid Exchange | 2001 |
[Comment on the short report by H. Krause and E.-I. Grussendorf: Syntopy of Bowen disease and mustard gas scar].
Topics: Aged; Arsenicals; Bowen's Disease; Burns, Chemical; Cell Transformation, Neoplastic; Cicatrix; Humans; Male; Mustard Gas; Skin; Skin Neoplasms | 1992 |
Cellular retention, toxicity and carcinogenic potential of seafood arsenic. I. Lack of cytotoxicity and transforming activity of arsenobetaine in the BALB/3T3 cell line.
Topics: Animals; Arsenic; Arsenic Poisoning; Arsenicals; Biotransformation; Cell Line; Cell Survival; Cell Transformation, Neoplastic; Food Contamination; Mice | 1991 |
Clinical cancer chemotherapy aimed at cellular control mechanisms.
Topics: Adult; Antineoplastic Agents; Arsenicals; Cell Transformation, Neoplastic; Culture Techniques; Female; Humans; Hyperbaric Oxygenation; Iodoacetates; Male; Middle Aged; Neoplasms | 1970 |
Metabolomic dynamics of the arsenic-transformed bronchial epithelial cells and the derived cancer stem-like cells.
Topics: Arsenic; Bronchi; Carcinogens, Environmental; Cell Line, Tumor; Cell Transformation, Neoplastic; Epithelial Cells; Humans; Metabolic Networks and Pathways; Metabolomics; Neoplastic Stem Cells | 2022 |
Arsenic activates STAT3 signaling during the transformation of the human bronchial epithelial cells.
Topics: Apoptosis Regulatory Proteins; Arsenic; Bronchi; Carcinogenesis; Cell Transformation, Neoplastic; Cells, Cultured; Epithelial Cells; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Phosphorylation; Reactive Oxygen Species; RNA-Binding Proteins; Signal Transduction; STAT3 Transcription Factor | 2022 |
The Potential Key Role of the NRF2/NQO1 Pathway in the Health Effects of Arsenic Pollution on SCC.
Topics: Arsenic; Arsenites; Cell Line; Cell Transformation, Neoplastic; Cyclin E; Humans; Keratinocytes; NAD(P)H Dehydrogenase (Quinone); NF-E2-Related Factor 2; RNA, Small Interfering | 2022 |
A Comprehensive Transcriptomic Analysis of Arsenic-Induced Bladder Carcinogenesis.
Topics: Arsenic; Cell Transformation, Neoplastic; Humans; Neoplastic Stem Cells; Phosphatidylinositol 3-Kinases; Transcriptome; Urinary Bladder | 2022 |
As-Cd-Pb Mixture Induces Cellular Transformation via Post-Transcriptional Regulation of Rad51c by miR-222.
Topics: Animals; Antagomirs; Arsenic; BALB 3T3 Cells; Cadmium; Cell Survival; Cell Transformation, Neoplastic; DNA Breaks, Double-Stranded; DNA-Binding Proteins; Gene Expression Regulation; Lead; Metals, Heavy; Mice; MicroRNAs; Rad51 Recombinase | 2019 |
Enhanced p62-NRF2 Feedback Loop due to Impaired Autophagic Flux Contributes to Arsenic-Induced Malignant Transformation of Human Keratinocytes.
Topics: Arsenic; Autophagic Cell Death; Cell Line; Cell Transformation, Neoplastic; Feedback, Physiological; Humans; Keratinocytes; Mechanistic Target of Rapamycin Complex 1; Neoplasm Proteins; NF-E2-Related Factor 2; Proteolysis; RNA-Binding Proteins; RNA, Neoplasm; Signal Transduction | 2019 |
Epigenetic regulations in alternative telomere lengthening: Understanding the mechanistic insight in arsenic-induced skin cancer patients.
Topics: Arsenic; Carcinogenesis; Cell Transformation, Neoplastic; DNA Methylation; Epigenesis, Genetic; Humans; Skin Neoplasms; Telomerase; Telomere; Telomere Homeostasis | 2020 |
Characterization of Arsenic-Induced Cancer Stem-Like Cells.
Topics: Arsenic; Bronchi; Cell Dedifferentiation; Cell Line; Cell Movement; Cell Proliferation; Cell Transformation, Neoplastic; Epithelial Cells; Gene Expression Regulation, Neoplastic; Humans; Neoplastic Stem Cells; Proto-Oncogene Proteins c-myc; Up-Regulation | 2020 |
Arsenic and benzo[a]pyrene co-exposure acts synergistically in inducing cancer stem cell-like property and tumorigenesis by epigenetically down-regulating SOCS3 expression.
Topics: Animals; Arsenic; Benzo(a)pyrene; Carcinogenesis; Carcinogens, Environmental; Cell Transformation, Neoplastic; Down-Regulation; Epigenesis, Genetic; Female; Humans; Male; Mice; Neoplastic Stem Cells; Suppressor of Cytokine Signaling 3 Protein | 2020 |
Effects of Inorganic Arsenic on Human Prostate Stem-Progenitor Cell Transformation, Autophagic Flux Blockade, and NRF2 Pathway Activation.
Topics: Animals; Arsenic; Cell Line; Cell Transformation, Neoplastic; Hazardous Substances; Humans; Male; Mice; Mice, Nude; NF-E2-Related Factor 2; Prostate; Rats; Stem Cells | 2020 |
Autophagy mediates bronchial cell malignant transformation induced by chronic arsenic exposure via MEK/ERK1/2 pathway.
Topics: Arsenic; Autophagy; Beclin-1; Bronchi; Bronchial Neoplasms; Cell Line, Tumor; Cell Movement; Cell Transformation, Neoplastic; Epithelial-Mesenchymal Transition; Humans; Inflammasomes; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Signal Transduction; Wound Healing | 2020 |
Integrin α4 up-regulation activates the hedgehog pathway to promote arsenic and benzo[α]pyrene co-exposure-induced cancer stem cell-like property and tumorigenesis.
Topics: Animals; Arsenic; Benzo(a)pyrene; Cell Line; Cell Transformation, Neoplastic; Gene Expression Regulation, Neoplastic; Hedgehog Proteins; Humans; Integrin alpha4; Lung Neoplasms; Mice; Neoplastic Stem Cells; Protein Stability; Repressor Proteins; Signal Transduction; Up-Regulation | 2020 |
FRA1 is essential for the maintenance of the oncogenic phenotype induced by
Topics: Animals; Arsenic; Carcinogenesis; Carcinogens; Cell Line; Cell Transformation, Neoplastic; Fibroblasts; Gene Expression Regulation, Neoplastic; Humans; Mice; Proto-Oncogene Proteins c-fos; Up-Regulation | 2020 |
Arsenic as an environmental toxicant and a therapeutic agent: Foe and friend.
Topics: Animals; Antineoplastic Agents; Arsenic; Arsenic Poisoning; Cell Transformation, Neoplastic; DNA Damage; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Humans; Neoplasms; Nervous System; Patient Safety; Risk Assessment; Risk Factors | 2021 |
Autophagy of the m
Topics: Adenosine; Alpha-Ketoglutarate-Dependent Dioxygenase FTO; Animals; Arsenic; Autophagy; Base Sequence; Carcinogenesis; Cell Transformation, Neoplastic; Down-Regulation; Epidermis; Gene Ontology; HaCaT Cells; HEK293 Cells; Humans; Keratinocytes; Lysosomes; Mice; Nedd4 Ubiquitin Protein Ligases; NF-kappa B; Protein Stability; RNA Stability; RNA, Messenger; Sequestosome-1 Protein; Transcriptome; Tumor Necrosis Factor-alpha; Up-Regulation; Vacuoles | 2021 |
M2 polarization of macrophages facilitates arsenic-induced cell transformation of lung epithelial cells.
Topics: Arsenic; Blotting, Western; Cell Differentiation; Cell Transformation, Neoplastic; Cells, Cultured; Coculture Techniques; Flow Cytometry; Humans; Lung Neoplasms; Macrophage Activation; Real-Time Polymerase Chain Reaction; Respiratory Mucosa | 2017 |
Long-term exposure of immortalized keratinocytes to arsenic induces EMT, impairs differentiation in organotypic skin models and mimics aspects of human skin derangements.
Topics: Animals; Arsenic; Arsenic Trioxide; Cell Culture Techniques; Cell Differentiation; Cell Transformation, Neoplastic; Epithelial-Mesenchymal Transition; Female; Humans; Keratinocytes; Mice, Inbred Strains; Organ Culture Techniques; Skin; Toxicity Tests, Chronic; Xenograft Model Antitumor Assays | 2018 |
Inactivation of miR-100 combined with arsenic treatment enhances the malignant transformation of BEAS-2B cells via stimulating epithelial -mesenchymal transition.
Topics: Animals; Arsenic; Bronchi; Carcinogenesis; Cell Movement; Cell Proliferation; Cell Transformation, Neoplastic; Epithelial Cells; Epithelial-Mesenchymal Transition; Heterografts; Humans; Mice; MicroRNAs; Signal Transduction | 2017 |
Flavonoids inhibit chronically exposed arsenic-induced proliferation and malignant transformation of HaCaT cells.
Topics: Antioxidants; Arsenic; Cell Line; Cell Proliferation; Cell Survival; Cell Transformation, Neoplastic; Flavonoids; Flavonols; Gamma Rays; Gene Expression; Humans; Intercellular Signaling Peptides and Proteins; Keratinocytes; Minor Histocompatibility Antigens; Neoplasm Proteins; Proto-Oncogene Proteins c-bcl-2; rab GTP-Binding Proteins; Silybin; Silymarin; Tenascin | 2018 |
Selective inhibition of CTCF binding by iAs directs TET-mediated reprogramming of 5-hydroxymethylation patterns in iAs-transformed cells.
Topics: 5-Methylcytosine; Arsenic; CCCTC-Binding Factor; Cell Transformation, Neoplastic; Dioxygenases; DNA Methylation; DNA-Binding Proteins; Humans; Mixed Function Oxygenases; Promoter Regions, Genetic; Proto-Oncogene Proteins | 2018 |
Arsenic promotes the COX2/PGE2-SOX2 axis to increase the malignant stemness properties of urothelial cells.
Topics: Arsenic; Biomarkers, Tumor; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cell Transformation, Neoplastic; Cyclooxygenase 2; Dinoprostone; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Neoplastic Stem Cells; SOXB1 Transcription Factors; Up-Regulation; Urothelium | 2018 |
Role of miR-31 and SATB2 in arsenic-induced malignant BEAS-2B cell transformation.
Topics: Arsenic; Carcinogenesis; Carcinogens; Cell Adhesion Molecules, Neuronal; Cell Line; Cell Transformation, Neoplastic; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; MicroRNAs; RNA, Messenger | 2018 |
[Effect of low-dose exposure to sodium arsenite on proliferation of HBE and HaCaT cells].
Topics: Arsenic; Arsenites; Cell Cycle; Cell Line; Cell Proliferation; Cell Transformation, Neoplastic; Cyclin D1; Epithelial Cells; Humans; Keratinocytes; Sodium Compounds; Up-Regulation | 2017 |
Arsenic Alters Exosome Quantity and Cargo to Mediate Stem Cell Recruitment Into a Cancer Stem Cell-Like Phenotype.
Topics: Arsenic; Cell Line, Tumor; Cell Transformation, Neoplastic; Environmental Pollutants; Epithelial Cells; Exosomes; Gene Expression; Humans; Male; Neoplastic Stem Cells; Prostate; Proto-Oncogene Proteins p21(ras); Signal Transduction | 2018 |
Malignant Transformation of Human Bronchial Epithelial Cells Induced by Arsenic through STAT3/miR-301a/SMAD4 Loop.
Topics: Apoptosis; Arsenic; Bronchi; Carcinogenesis; Cell Movement; Cell Proliferation; Cell Transformation, Neoplastic; Epithelial Cells; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; MicroRNAs; Neoplasms; Reactive Oxygen Species; Signal Transduction; Smad4 Protein; STAT3 Transcription Factor | 2018 |
Long-Term Combinatorial Exposure to Trichloroethylene and Inorganic Arsenic in Genetically Heterogeneous Mice Results in Renal Tubular Damage and Cancer-Associated Molecular Changes.
Topics: Animals; Arsenic; Biomarkers; Cell Transformation, Neoplastic; Disease Models, Animal; Drug Synergism; Environmental Exposure; Genetic Predisposition to Disease; Kaplan-Meier Estimate; Kidney Function Tests; Kidney Neoplasms; Kidney Tubules; Male; Mice; Mice, Transgenic; Mutation; Prognosis; Trichloroethylene; Von Hippel-Lindau Tumor Suppressor Protein | 2019 |
Exposure of low-concentration arsenic-initiated inflammation and autophagy in rat lungs.
Topics: Animals; Arsenic; Autophagy; Cell Transformation, Neoplastic; Dose-Response Relationship, Drug; Inflammation; Lung; Lung Neoplasms; Male; Pneumonia; Rats; Rats, Sprague-Dawley | 2019 |
Arsenic-Induced Neoplastic Transformation Involves Epithelial-Mesenchymal Transition and Activation of the β-Catenin/c-Myc Pathway in Human Kidney Epithelial Cells.
Topics: Arsenic; beta Catenin; Cell Proliferation; Cell Transformation, Neoplastic; Cells, Cultured; Epithelial Cells; Epithelial-Mesenchymal Transition; Humans; Proto-Oncogene Proteins c-myc | 2019 |
Analysis of the dynamic aberrant landscape of DNA methylation and gene expression during arsenic-induced cell transformation.
Topics: Animals; Arsenic; Cell Line, Tumor; Cell Transformation, Neoplastic; DNA Methylation; Epigenesis, Genetic; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Mice; Neoplasm Transplantation; Oligonucleotide Array Sequence Analysis; Promoter Regions, Genetic; Skin Neoplasms | 2019 |
Uncoupling RARA transcriptional activation and degradation clarifies the bases for APL response to therapies.
Topics: Animals; Antineoplastic Agents; Arsenic; Cell Differentiation; Cell Line; Cell Transformation, Neoplastic; Gene Expression Regulation, Leukemic; Humans; Leukemia, Promyelocytic, Acute; Mice; Nuclear Proteins; Promyelocytic Leukemia Protein; Proteolysis; Receptors, Retinoic Acid; Retinoic Acid Receptor alpha; Transcription Factors; Transcriptional Activation; Tretinoin; Tumor Suppressor Proteins | 2013 |
CD44v6 expression in human skin keratinocytes as a possible mechanism for carcinogenesis associated with chronic arsenic exposure.
Topics: Animals; Arsenic; Arsenites; Carcinoma, Squamous Cell; Cell Transformation, Neoplastic; Enzyme Inhibitors; Humans; Hyaluronan Receptors; Keratinocytes; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; Neoplastic Stem Cells; NF-kappa B; Skin; Skin Neoplasms; Sodium Compounds; Transplantation, Heterologous; Tumor Suppressor Protein p53 | 2013 |
Regulation of cellular Cyclin D1 gene by arsenic is mediated through miR-2909.
Topics: Apoptosis; Apoptosis Regulatory Proteins; Arsenic; B-Cell Lymphoma 3 Protein; Cell Line, Tumor; Cell Transformation, Neoplastic; Deubiquitinating Enzyme CYLD; Genes, bcl-1; Humans; Kruppel-Like Factor 4; Kruppel-Like Transcription Factors; Leukocytes, Mononuclear; Lymphoma, B-Cell; MicroRNAs; Protein Biosynthesis; Proto-Oncogene Proteins; Repressor Proteins; Sp1 Transcription Factor; Transcription Factors; Tumor Suppressor Proteins | 2013 |
Chronic exposure to arsenic, estrogen, and their combination causes increased growth and transformation in human prostate epithelial cells potentially by hypermethylation-mediated silencing of MLH1.
Topics: Adaptor Proteins, Signal Transducing; Arsenic; Cell Cycle; Cell Enlargement; Cell Line; Cell Transformation, Neoplastic; Epithelial Cells; Estrogens; Gene Expression; Gene Silencing; Humans; Male; Methylation; MutL Protein Homolog 1; Nuclear Proteins; Prostate | 2013 |
Arsenic-induced cancer cell phenotype in human breast epithelia is estrogen receptor-independent but involves aromatase activation.
Topics: Aromatase; Arsenic; Breast Neoplasms; Cell Line; Cell Transformation, Neoplastic; Epithelial Cells; Epithelial-Mesenchymal Transition; Estradiol; Estrogen Receptor alpha; Female; Humans; Mammary Glands, Human; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Neoplastic Stem Cells; Receptors, Estrogen; Toxicity Tests, Chronic | 2014 |
Prediction of the number of activated genes in multiple independent Cd(+2)- and As(+3)-induced malignant transformations of human urothelial cells (UROtsa).
Topics: Algorithms; Arsenic; Cadmium; Cell Line; Cell Transformation, Neoplastic; Cluster Analysis; Computational Biology; Computer Simulation; Epithelial Cells; Humans; Models, Genetic; Oligonucleotide Array Sequence Analysis; Reverse Transcriptase Polymerase Chain Reaction; Transcriptome; Urothelium | 2014 |
Arsenic-induced sub-lethal stress reprograms human bronchial epithelial cells to CD61¯ cancer stem cells.
Topics: Animals; Arsenic; Breast Neoplasms; Bronchi; Cell Line; Cell Transformation, Neoplastic; Cellular Reprogramming; DNA Repair; Epithelium; Female; Gene Expression; Gene Knockdown Techniques; Genes, myc; Humans; Integrin beta3; JNK Mitogen-Activated Protein Kinases; Kruppel-Like Factor 4; Kruppel-Like Transcription Factors; Lung Neoplasms; Male; Mice; Mice, Inbred BALB C; Mice, Inbred NOD; Mice, SCID; Neoplasms, Experimental; Neoplastic Stem Cells; Octamer Transcription Factor-3; Ovarian Neoplasms; Phenotype; Phosphorylation; Receptors, Interleukin-2; SOXB1 Transcription Factors; Spheroids, Cellular; Stress, Physiological; Survival Rate | 2014 |
Assessing the impact of As-Cd-Pb metal mixture on cell transformation by two-stage Balb/c 3T3 cell assay.
Topics: 3T3 Cells; Animals; Arsenic; Biological Assay; Cadmium; Cell Cycle; Cell Survival; Cell Transformation, Neoplastic; Cellular Senescence; DNA Damage; Humans; Lead; Metallothionein; Metals, Heavy; Mice; Mice, Inbred BALB C; Mutagenicity Tests; Reactive Oxygen Species | 2014 |
Autophagy inhibition by sustained overproduction of IL6 contributes to arsenic carcinogenesis.
Topics: Animals; Apoptosis Regulatory Proteins; Arsenic; Autophagy; Beclin-1; Cell Line; Cell Transformation, Neoplastic; Epithelial Cells; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Interleukin-6; Male; Membrane Proteins; Mice; Myeloid Cell Leukemia Sequence 1 Protein; Protein Binding; RNA, Messenger; STAT3 Transcription Factor; TOR Serine-Threonine Kinases | 2014 |
Arsenite-mediated promotion of anchorage-independent growth of HaCaT cells through placental growth factor.
Topics: Animals; Arsenic; Arsenic Poisoning; Arsenites; Bangladesh; Cell Adhesion; Cell Line; Cell Line, Tumor; Cell Transformation, Neoplastic; Disease Models, Animal; Environmental Pollutants; Humans; Immunohistochemistry; Keratinocytes; MAP Kinase Kinase Kinases; Mice; Placenta Growth Factor; Pregnancy Proteins; Proteasome Endopeptidase Complex; RNA Interference; RNA, Messenger; Signal Transduction; Skin Neoplasms; Urine; Vascular Endothelial Growth Factor Receptor-1; Water Pollutants, Chemical | 2015 |
Role of reactive oxygen species in arsenic-induced transformation of human lung bronchial epithelial (BEAS-2B) cells.
Topics: Apoptosis; Arsenic; Bronchi; Carcinogens, Environmental; Catalase; Cell Line; Cell Transformation, Neoplastic; Humans; Reactive Oxygen Species; Respiratory Mucosa | 2015 |
Involvement of epigenetics and EMT-related miRNA in arsenic-induced neoplastic transformation and their potential clinical use.
Topics: Adult; Aged; Aged, 80 and over; Apoptosis; Arsenic; Biomarkers, Tumor; Blotting, Western; Case-Control Studies; Cell Movement; Cell Proliferation; Cell Transformation, Neoplastic; Cells, Cultured; Cohort Studies; DNA Methylation; Epigenesis, Genetic; Epithelial-Mesenchymal Transition; Female; Gene Expression Regulation, Neoplastic; Humans; Immunoenzyme Techniques; Male; MicroRNAs; Middle Aged; Neoplasm Invasiveness; PTEN Phosphohydrolase; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; TOR Serine-Threonine Kinases; Urinary Bladder; Urinary Bladder Neoplasms; Young Adult | 2015 |
A Potential New Mechanism of Arsenic Carcinogenesis: Depletion of Stem-Loop Binding Protein and Increase in Polyadenylated Canonical Histone H3.1 mRNA.
Topics: Arsenic; Binding Sites; Cell Line; Cell Transformation, Neoplastic; Epigenesis, Genetic; Gene Expression Regulation; Gene Knockdown Techniques; Histones; Humans; Inverted Repeat Sequences; Molecular Sequence Data; mRNA Cleavage and Polyadenylation Factors; Nuclear Proteins; Polyadenylation; RNA, Messenger; S Phase | 2015 |
p38α MAPK is required for arsenic-induced cell transformation.
Topics: Animals; Arsenic; BALB 3T3 Cells; Cell Transformation, Neoplastic; Cyclic AMP Response Element-Binding Protein; Gene Expression Regulation, Neoplastic; Mice; Mitogen-Activated Protein Kinase 14; Phosphorylation; Signal Transduction; Transcription Factor AP-1 | 2016 |
Identification of novel gene targets and putative regulators of arsenic-associated DNA methylation in human urothelial cells and bladder cancer.
Topics: Adult; Aged; Arsenic; Cell Transformation, Neoplastic; DNA Methylation; Female; Humans; Middle Aged; Urinary Bladder Neoplasms; Urothelium; Young Adult | 2015 |
[Dynamic changes of ROS, MDA and SOD during arsenic-induced neoplastic transformation in human keratinocytes].
Topics: Arsenic; Arsenites; Cell Line; Cell Transformation, Neoplastic; Humans; Keratinocytes; Oxidation-Reduction; Sodium Compounds | 2015 |
Antioncogenic and Oncogenic Properties of Nrf2 in Arsenic-induced Carcinogenesis.
Topics: Antioxidants; Apoptosis; Arsenic; Autophagy; bcl-X Protein; Carcinogenesis; Catalase; Cell Line; Cell Survival; Cell Transformation, Neoplastic; Gene Knockdown Techniques; Genes, Tumor Suppressor; Humans; Models, Biological; NF-E2-Related Factor 2; Oncogenes; Promoter Regions, Genetic; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; RNA-Binding Proteins; Superoxide Dismutase | 2015 |
Role and mechanism of miR-222 in arsenic-transformed cells for inducing tumor growth.
Topics: Animals; Apoptosis; Arsenic; Arsenic Poisoning; Cell Line, Transformed; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; Human Umbilical Vein Endothelial Cells; Humans; Lung Neoplasms; Mice; Mice, Inbred BALB C; Mice, Nude; MicroRNAs; PTEN Phosphohydrolase; Respiratory Mucosa; Up-Regulation | 2016 |
Bhas 42 cell transformation activity of cigarette smoke condensate is modulated by selenium and arsenic.
Topics: Animals; Arsenic; Carcinogenicity Tests; Cell Line, Transformed; Cell Transformation, Neoplastic; Dimethyl Sulfoxide; Dose-Response Relationship, Drug; Mice; Selenium; Smoking; Toxicity Tests | 2016 |
Metal mixture (As-Cd-Pb)-induced cell transformation is modulated by OLA1.
Topics: Adenosine Triphosphatases; Animals; Arsenic; Cadmium; Cell Line; Cell Transformation, Neoplastic; Environmental Pollutants; Gene Knockdown Techniques; Lead; Mice; Oxidative Stress; RNA, Small Interfering | 2016 |
Quantitative Mass Spectrometry Reveals Changes in Histone H2B Variants as Cells Undergo Inorganic Arsenic-Mediated Cellular Transformation.
Topics: Arsenic; Cell Line; Cell Transformation, Neoplastic; Chromatin; Dose-Response Relationship, Drug; Epithelial-Mesenchymal Transition; Genetic Variation; HeLa Cells; Histones; Humans; Tandem Mass Spectrometry | 2016 |
Upregulation of glycolysis and oxidative phosphorylation in benzo[α]pyrene and arsenic-induced rat lung epithelial transformed cells.
Topics: Adenosine Triphosphate; Animals; Arsenic; Benzo(a)pyrene; Cell Line, Transformed; Cell Transformation, Neoplastic; Epithelial Cells; Female; Glycolysis; Humans; Hypoxia; Lung; Mice; Mice, Nude; Oxidative Phosphorylation; Proteomics; Rats; Up-Regulation | 2016 |
[Biological effects of arsenic and diseases: The mechanisms involved in arsenic-induced carcinogenesis].
Topics: Animals; Arsenic; Carcinogens; Cell Transformation, Neoplastic; Cellular Senescence; DNA Damage; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Humans; Mutation | 2016 |
Oncogenic transformation of human lung bronchial epithelial cells induced by arsenic involves ROS-dependent activation of STAT3-miR-21-PDCD4 mechanism.
Topics: Apoptosis Regulatory Proteins; Arsenic; Bronchi; Bronchial Neoplasms; Cell Line, Transformed; Cell Transformation, Neoplastic; Epithelial Cells; Humans; MicroRNAs; Neoplasm Proteins; Reactive Oxygen Species; Respiratory Mucosa; RNA-Binding Proteins; RNA, Neoplasm; STAT3 Transcription Factor | 2016 |
Arsenic Induces p62 Expression to Form a Positive Feedback Loop with Nrf2 in Human Epidermal Keratinocytes: Implications for Preventing Arsenic-Induced Skin Cancer.
Topics: Animals; Arsenic; Autophagy; Cell Proliferation; Cell Transformation, Neoplastic; Disease Models, Animal; Gene Expression Regulation; Gene Knockdown Techniques; Humans; Keratinocytes; Male; Mice; NF-E2-Related Factor 2; Protein Binding; RNA, Messenger; Sequestosome-1 Protein; Skin Neoplasms | 2017 |
Genome-wide DNA methylation reprogramming in response to inorganic arsenic links inhibition of CTCF binding, DNMT expression and cellular transformation.
Topics: Alternative Splicing; Arsenic; CCCTC-Binding Factor; Cell Transformation, Neoplastic; Cellular Reprogramming; Chromosomes, Human; CpG Islands; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Epithelial-Mesenchymal Transition; Gene Ontology; Genome, Human; Humans; Promoter Regions, Genetic; Protein Binding; Reproducibility of Results; Transcription, Genetic | 2017 |
Induction of cytoplasmic accumulation of p53: a mechanism for low levels of arsenic exposure to predispose cells for malignant transformation.
Topics: Animals; Arsenic; Cell Line, Tumor; Cell Transformation, Neoplastic; Cytoplasm; DNA Damage; Extracellular Signal-Regulated MAP Kinases; Fluorouracil; Humans; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Promoter Regions, Genetic; Proto-Oncogene Proteins c-mdm2; Tumor Suppressor Protein p53 | 2008 |
Comparison of gene expression profiles in HepG2 cells exposed to arsenic, cadmium, nickel, and three model carcinogens for investigating the mechanisms of metal carcinogenesis.
Topics: Arsenic; Base Sequence; Cadmium; Carcinogens; Cell Line; Cell Transformation, Neoplastic; DNA Primers; Gene Expression Profiling; Humans; Nickel; Oligonucleotide Array Sequence Analysis; Polymerase Chain Reaction; Reactive Oxygen Species; Reverse Transcriptase Polymerase Chain Reaction | 2009 |
Acute promyelocytic leukemia--weapons of mass differentiation.
Topics: Animals; Antineoplastic Agents; Arsenic; Cell Differentiation; Cell Transformation, Neoplastic; Gene Expression Regulation, Neoplastic; Humans; Leukemia, Promyelocytic, Acute; Mice; Oncogene Proteins, Fusion; Tretinoin | 2009 |
Differential effects of arsenic on cutaneous and systemic immunity: focusing on CD4+ cell apoptosis in patients with arsenic-induced Bowen's disease.
Topics: Aged; Apoptosis; Arsenic; Bowen's Disease; CD4-Positive T-Lymphocytes; Cell Transformation, Neoplastic; Cells, Cultured; Fas Ligand Protein; Female; Humans; Immunity, Active; Keratinocytes; Male; Middle Aged; Skin Neoplasms | 2009 |
Induction of neoplastic transformation by ectopic expression of human aldo-keto reductase 1C isoforms in NIH3T3 cells.
Topics: 20-Hydroxysteroid Dehydrogenases; Alcohol Oxidoreductases; Aldehyde Reductase; Aldo-Keto Reductases; Animals; Arsenic; Base Sequence; Cell Transformation, Neoplastic; DNA Primers; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Isoenzymes; Keratinocytes; Mice; NIH 3T3 Cells; Transfection | 2009 |
Arsenicals produce stable progressive changes in DNA methylation patterns that are linked to malignant transformation of immortalized urothelial cells.
Topics: Animals; Arsenic; Cell Line; Cell Transformation, Neoplastic; CpG Islands; DNA Methylation; Mice; Mice, SCID; Oligonucleotide Array Sequence Analysis; Organometallic Compounds; Promoter Regions, Genetic; Urothelium | 2009 |
Arsenic exposure transforms human epithelial stem/progenitor cells into a cancer stem-like phenotype.
Topics: Adult Stem Cells; Animals; Arsenic; Arsenites; Carcinogens, Environmental; Cell Line; Cell Transformation, Neoplastic; Gene Expression; Humans; Male; Matrix Metalloproteinase 9; Membrane Proteins; Mice; Mice, Nude; Neoplasms, Experimental; Neoplastic Stem Cells; Phenotype; Prostate; PTEN Phosphohydrolase; Spheroids, Cellular; Transplantation, Heterologous | 2010 |
Reduced reactive oxygen species-generating capacity contributes to the enhanced cell growth of arsenic-transformed epithelial cells.
Topics: Arsenic; Blotting, Western; Bronchi; Catalase; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; Colony-Forming Units Assay; Electrophoretic Mobility Shift Assay; Epithelial Cells; Fluorescent Antibody Technique; Humans; NF-kappa B; Oxidative Stress; Reactive Oxygen Species; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Small Interfering; Signal Transduction; Superoxide Dismutase | 2010 |
Immunological profile of arsenic toxicity: a hint towards arsenic-induced carcinogenesis.
Topics: Alkylating Agents; Animals; Apoptosis; Arsenic; Caspases; Cell Transformation, Neoplastic; Cytokines; Ethylnitrosourea; Female; Humans; Male; Mice; Neoplasms, Experimental; Tissue Distribution | 2010 |
Activation and up-regulation of translation initiation factor 4B contribute to arsenic-induced transformation.
Topics: Animals; Arsenic; Cell Line; Cell Transformation, Neoplastic; Eukaryotic Initiation Factors; Gene Knockdown Techniques; Genes, myc; Mice; Phosphorylation; Proto-Oncogene Proteins c-akt; Ribosomal Protein S6 Kinases; Up-Regulation | 2011 |
Reversal and prevention of arsenic-induced human bronchial epithelial cell malignant transformation by microRNA-200b.
Topics: Animals; Arsenic; Base Sequence; Bronchi; Cell Transformation, Neoplastic; DNA Methylation; DNA Primers; Epithelial Cells; Humans; Mice; Mice, Nude; MicroRNAs; Reverse Transcriptase Polymerase Chain Reaction | 2011 |
Mitochondrial biogenesis drives tumor cell proliferation.
Topics: Animals; Arsenic; Bowen's Disease; Cell Proliferation; Cell Transformation, Neoplastic; Humans; Mitochondria; Skin Neoplasms | 2011 |
Aberrant cell proliferation by enhanced mitochondrial biogenesis via mtTFA in arsenical skin cancers.
Topics: Aged; Arsenic; Arsenic Poisoning; Blotting, Western; Bowen's Disease; Cell Proliferation; Cell Respiration; Cell Transformation, Neoplastic; DNA-Binding Proteins; Humans; Immunohistochemistry; Keratinocytes; Mitochondria; Mitochondrial Proteins; Reverse Transcriptase Polymerase Chain Reaction; Skin Neoplasms; Transcription Factors | 2011 |
Reply to "Reversal and prevention of arsenic-induced human bronchial epithelial cell malignant transformation by microRNA-200b".
Topics: Animals; Arsenic; Bronchi; Cell Transformation, Neoplastic; Humans; MicroRNAs | 2011 |
Devastating environmental threads: arsenic exposure and carcinogenesis.
Topics: Arsenic; Carcinogens, Environmental; Cell Transformation, Neoplastic; Humans | 2011 |
Akt activation is responsible for enhanced migratory and invasive behavior of arsenic-transformed human bronchial epithelial cells.
Topics: Arsenic; Bronchi; Cell Line; Cell Movement; Cell Transformation, Neoplastic; Epithelial Cells; Homeodomain Proteins; Humans; Neoplasm Invasiveness; Proto-Oncogene Proteins c-akt; Repressor Proteins; Respiratory Mucosa; Transcription Factors; Transcriptional Activation; Zinc Finger E-box Binding Homeobox 2; Zinc Finger E-box-Binding Homeobox 1 | 2012 |
Overabundance of putative cancer stem cells in human skin keratinocyte cells malignantly transformed by arsenic.
Topics: Antigens, CD34; Arsenic; Biomarkers; Cell Line; Cell Transformation, Neoplastic; Fluorescent Antibody Technique; Humans; Keratinocytes; Matrix Metalloproteinase 9; Microscopy, Fluorescence; Neoplastic Stem Cells; Real-Time Polymerase Chain Reaction; Skin Neoplasms | 2012 |
Barium promotes anchorage-independent growth and invasion of human HaCaT keratinocytes via activation of c-SRC kinase.
Topics: Animals; Arsenic; Bangladesh; Barium; Cell Adhesion; Cell Movement; Cell Proliferation; Cell Transformation, Neoplastic; CSK Tyrosine-Protein Kinase; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Fibroblasts; Focal Adhesion Protein-Tyrosine Kinases; Humans; Keratinocytes; Matrix Metalloproteinase 14; Melanocytes; Mice; NIH 3T3 Cells; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; src-Family Kinases; Vietnam; Water Pollution; Water Wells | 2011 |
Role of oxidative stress in transformation induced by metal mixture.
Topics: Acetylcysteine; Air Pollutants; Animals; Arsenic; BALB 3T3 Cells; Cadmium; Carcinogens, Environmental; Cell Survival; Cell Transformation, Neoplastic; Free Radical Scavengers; Humans; Lead; Mice; Oxidative Stress; Reactive Oxygen Species | 2011 |
Arsenic-transformed malignant prostate epithelia can convert noncontiguous normal stem cells into an oncogenic phenotype.
Topics: Arsenic; Blotting, Western; Cell Line, Tumor; Cell Transformation, Neoplastic; Epithelial Cells; Fluorescent Antibody Technique; Gene Expression Regulation, Neoplastic; Humans; Interleukin-6; Male; Matrix Metalloproteinases; Neoplastic Stem Cells; Prostatic Neoplasms; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction | 2012 |
Bad neighbors: arsenic-induced tumor cells convert normal stem cells into a cancerous phenotype.
Topics: Arsenic; Cell Transformation, Neoplastic; Epithelial Cells; Gene Expression Regulation, Neoplastic; Humans; Male; Neoplastic Stem Cells; Prostatic Neoplasms | 2012 |
Gene expression changes in human lung cells exposed to arsenic, chromium, nickel or vanadium indicate the first steps in cancer.
Topics: Arsenic; Bronchi; Carcinogens; Cell Line; Cell Transformation, Neoplastic; Chromium; Epithelial Cells; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Nickel; Vanadium | 2012 |
Therapeutic profile of T11TS vs. T11TS+MiADMSA: a hunt for a more effective therapeutic regimen for arsenic exposure.
Topics: Animals; Apoptosis; Arsenic; Arsenic Poisoning; CD2 Antigens; Cell Transformation, Neoplastic; Chelating Agents; Chelation Therapy; Cytokines; Drug Therapy, Combination; Environmental Exposure; Lymphocytes; Mice; Oxidative Stress; Succimer | 2012 |
Agglomerates of aberrant DNA methylation are associated with toxicant-induced malignant transformation.
Topics: Animals; Arsenic; Cadherins; Carcinoma; Cell Line, Tumor; Cell Transformation, Neoplastic; DNA Methylation; DNA, Neoplasm; Epigenesis, Genetic; Female; Genes, Homeobox; Histones; Humans; Lysine; Male; Mice; Mice, Nude; Multigene Family; Neoplasm Transplantation; Prostatic Neoplasms; Protein Processing, Post-Translational | 2012 |
Chronic exposure of renal stem cells to inorganic arsenic induces a cancer phenotype.
Topics: AC133 Antigen; Animals; Antigens, CD; Arsenic; CD24 Antigen; Cell Line; Cell Proliferation; Cell Transformation, Neoplastic; Cyclooxygenase 2; Glycoproteins; Humans; Kidney; Kidney Neoplasms; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Metallothionein; Mice; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplastic Stem Cells; Peptides; Rats; Stem Cells; Superoxide Dismutase; Superoxide Dismutase-1 | 2013 |
Arsenite cocarcinogenesis: an animal model derived from genetic toxicology studies.
Topics: Animals; Arsenic; Arsenites; Carcinoma, Squamous Cell; Cell Transformation, Neoplastic; Disease Models, Animal; DNA Damage; DNA Repair; Risk Assessment; Skin Neoplasms; Teratogens; Ultraviolet Rays; Water Supply | 2002 |
The molecular mechanisms of arsenic-induced cell transformation and apoptosis.
Topics: Animals; Apoptosis; Arsenic; Cell Transformation, Neoplastic; Dose-Response Relationship, Drug; Gene Expression Regulation; Genes, p53; Humans; JNK Mitogen-Activated Protein Kinases; Mice; Mitogen-Activated Protein Kinases; Phosphorylation; Signal Transduction; Skin | 2002 |
Proteomic analyses of arsenic-induced cell transformation with SELDI-TOF ProteinChip technology.
Topics: Animals; Arsenic; Arsenites; Benzo(a)pyrene; Carcinogens; Cell Line, Transformed; Cell Transformation, Neoplastic; Dose-Response Relationship, Drug; Protein Array Analysis; Proteome; Rats; Rats, Inbred F344; Time Factors; Tumor Cells, Cultured | 2003 |
Characterization of gene expression changes associated with MNNG, arsenic, or metal mixture treatment in human keratinocytes: application of cDNA microarray technology.
Topics: Arsenic; Cell Culture Techniques; Cell Transformation, Neoplastic; DNA Repair; Gene Expression Profiling; Gene Expression Regulation; Genetic Markers; Humans; Keratinocytes; Methylnitronitrosoguanidine; Oligonucleotide Array Sequence Analysis; Protein Kinases; Risk Assessment; Xenobiotics | 2002 |
UV filters with antagonistic action at androgen receptors in the MDA-kb2 cell transcriptional-activation assay.
Topics: Arsenic; Biomarkers; Carcinogens; Cell Line; Cell Transformation, Neoplastic; DNA Primers; Gene Expression Regulation, Neoplastic; Humans; Keratinocytes; Metals; Methylnitronitrosoguanidine; Oligonucleotide Array Sequence Analysis; Reverse Transcriptase Polymerase Chain Reaction | 2003 |
Acquisition of androgen independence by human prostate epithelial cells during arsenic-induced malignant transformation.
Topics: Androgen Antagonists; Androgens; Animals; Arsenic; Cell Line; Cell Proliferation; Cell Transformation, Neoplastic; Dihydrotestosterone; Epidermal Growth Factor; Epithelial Cells; Estradiol; Estrogen Receptor alpha; Estrogen Receptor beta; Flutamide; Gene Expression Regulation; Humans; Male; Mice; Pituitary Gland; Prostate; Prostatic Neoplasms; Receptors, Androgen; RNA, Messenger | 2005 |
Aurora-A overexpression associates with Ha-ras codon-12 mutation and blackfoot disease endemic area in bladder cancer.
Topics: Arsenic; Aurora Kinases; Cell Line, Tumor; Cell Transformation, Neoplastic; Codon; Endemic Diseases; Genes, ras; Humans; Mutation; Peripheral Vascular Diseases; Polymorphism, Single Nucleotide; Protein Serine-Threonine Kinases; RNA, Messenger | 2006 |
Proteomic and biochemical analyses of in vitro carcinogen-induced lung cell transformation: synergism between arsenic and benzo[a]pyrene.
Topics: Actinin; Actins; Animals; Arsenic; Benzo(a)pyrene; Carcinogens; Cell Line; Cell Transformation, Neoplastic; Electrophoresis, Gel, Two-Dimensional; Extracellular Signal-Regulated MAP Kinases; Intermediate Filament Proteins; Lung; MAP Kinase Signaling System; Membrane Glycoproteins; Nerve Tissue Proteins; Peptides; Peripherins; Proteome; Rats; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2006 |
Enhanced expression of metallothionein isoform 3 protein in tumor heterotransplants derived from As+3- and Cd+2-transformed human urothelial cells.
Topics: Animals; Arsenic; Biomarkers, Tumor; Breast Neoplasms; Cadmium; Cell Transformation, Neoplastic; Cells, Cultured; Female; Humans; Immunohistochemistry; Male; Metallothionein; Metallothionein 3; Mice; Neoplasm Transplantation; Prostatic Neoplasms; Protein Isoforms; RNA, Messenger; Transplantation, Heterologous; Urinary Bladder Neoplasms | 2006 |
Further studies on aberrant gene expression associated with arsenic-induced malignant transformation in rat liver TRL1215 cells.
Topics: Animals; Arsenic; Arsenites; Azacitidine; Blotting, Western; Carcinogens; Cell Cycle; Cell Line; Cell Transformation, Neoplastic; Dealkylation; Decitabine; DNA, Neoplasm; Gene Expression; Gene Expression Regulation, Developmental; Gene Expression Regulation, Neoplastic; Growth; Intercellular Signaling Peptides and Proteins; Liver Neoplasms; Rats; Reverse Transcriptase Polymerase Chain Reaction; Stress, Physiological | 2006 |
Mechanisms of acquired androgen independence during arsenic-induced malignant transformation of human prostate epithelial cells.
Topics: Androgens; Arsenic; Blotting, Western; Cell Proliferation; Cell Transformation, Neoplastic; Cells, Cultured; Environmental Pollutants; Epithelial Cells; Humans; Male; MAP Kinase Signaling System; Models, Biological; Prostate; Prostatic Neoplasms; Proto-Oncogene Proteins p21(ras); raf Kinases; Receptor, ErbB-2; Receptors, Androgen; Reverse Transcriptase Polymerase Chain Reaction | 2007 |
GATA-1 and Gfi-1B interplay to regulate Bcl-xL transcription.
Topics: Apoptosis; Arsenic; bcl-X Protein; Benzamides; Binding Sites; Cell Line; Cell Line, Transformed; Cell Transformation, Neoplastic; Chromatin Immunoprecipitation; Fusion Proteins, bcr-abl; GATA1 Transcription Factor; Gene Expression Regulation; Genes, Reporter; Humans; Imatinib Mesylate; K562 Cells; Luciferases; Piperazines; Promoter Regions, Genetic; Protein Binding; Proto-Oncogene Proteins; Pyrimidines; Repressor Proteins; Retroviridae; Transcription, Genetic; Transcriptional Activation | 2007 |
Arsenic-induced changes in the gene expression of lung epithelial L2 cells: implications in carcinogenesis.
Topics: Animals; Arsenic; Carcinogens; Cell Differentiation; Cell Survival; Cell Transformation, Neoplastic; Cells, Cultured; Cluster Analysis; Dose-Response Relationship, Drug; Epithelial Cells; Gene Expression; Lung; Lung Neoplasms; Oligonucleotide Array Sequence Analysis; Rats | 2008 |
Molecular basis for effects of carcinogenic heavy metals on inducible gene expression.
Topics: Animals; Arsenic; Cell Transformation, Neoplastic; Chick Embryo; Chromium; Environmental Exposure; Gene Expression; Genetic Markers; Humans; Neoplasms; Promoter Regions, Genetic; Rats; Toxicity Tests; Transcription Factors | 1998 |
Arsenic, dioxin, and the promotional step in cancer creation.
Topics: Arsenic; Carcinogens; Cell Transformation, Neoplastic; Environmental Exposure; Female; Humans; Incidence; Male; Neoplasms; Occupational Exposure; Polychlorinated Dibenzodioxins; Sex Distribution; Survival Rate | 2000 |
Oral exposure of dimethylarsinic acid, a main metabolite of inorganic arsenics, in mice leads to an increase in 8-Oxo-2'-deoxyguanosine level, specifically in the target organs for arsenic carcinogenesis.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Arsenic; Cacodylic Acid; Carcinogenicity Tests; Cell Transformation, Neoplastic; Chromatography, High Pressure Liquid; Deoxyguanosine; Enzyme-Linked Immunosorbent Assay; Female; Male; Mice; Mice, Hairless; Tissue Distribution | 2001 |
Acquisition of apoptotic resistance in arsenic-induced malignant transformation: role of the JNK signal transduction pathway.
Topics: Animals; Apoptosis; Arsenic; bcl-2-Associated X Protein; Blotting, Western; Cell Line, Transformed; Cell Transformation, Neoplastic; Drug Resistance; Enzyme Activation; Flow Cytometry; Hepatocytes; In Situ Nick-End Labeling; Indoles; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase 4; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Phosphorylation; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Inbred F344; Signal Transduction | 2002 |
Quantitative studies of in vitro morphological transformation of Syrian hamster cells by inorganic metal salts.
Topics: Animals; Arsenic; Beryllium; Cadmium; Cell Transformation, Neoplastic; Cells, Cultured; Chromium; Cricetinae; Dose-Response Relationship, Drug; Embryo, Mammalian; Female; Maternal-Fetal Exchange; Mesocricetus; Metals; Nickel; Pregnancy | 1979 |
Novel ATP-binding heat-inducible protein of Mr = 37,000 that is sensitive to transformation in BALB/3T3 cells.
Topics: 2,2'-Dipyridyl; Adenosine Triphosphate; Animals; Arsenic; Arsenites; Calcimycin; Carrier Proteins; Cell Transformation, Neoplastic; Cell Transformation, Viral; Cells, Cultured; Chick Embryo; Electrophoresis, Polyacrylamide Gel; Endoplasmic Reticulum Chaperone BiP; Fibroblasts; Heat-Shock Proteins; Methionine; Mice; Mice, Inbred BALB C; Precipitin Tests; Sepharose; Sulfur Radioisotopes; Tetradecanoylphorbol Acetate; Tunicamycin | 1990 |
Cellular uptake and metabolic reduction of pentavalent to trivalent arsenic as determinants of cytotoxicity and morphological transformation.
Topics: Animals; Arsenates; Arsenic; Arsenites; Biological Transport; Biotransformation; Cell Transformation, Neoplastic; Cells, Cultured; Kinetics; Mice; Mice, Inbred BALB C; Sodium Compounds | 1987 |
Different modes of action of sodium arsenite, 3-aminobenzamide, and caffeine on the enhancement of ethyl methanesulfonate clastogenicity.
Topics: Animals; Arsenic; Arsenites; Benzamides; Caffeine; Cell Cycle; Cell Line; Cell Transformation, Neoplastic; Chromatids; Chromosome Aberrations; Cricetinae; Cricetulus; Female; Methyl Methanesulfonate; Ovary; Sodium Compounds; Sulfhydryl Reagents | 1986 |
Carcinogenicity and mutagenicity of some metals and their compounds.
Topics: Animals; Arsenic; Cadmium; Carcinogens; Cell Transformation, Neoplastic; Chromium; Chromosome Aberrations; DNA; DNA Damage; DNA-Directed DNA Polymerase; Humans; Metals; Microsomes, Liver; Mutagens; Nickel; Nucleoproteins; Platinum; Tin; Transcription, Genetic | 1986 |
Comparison of arsenic-induced cell transformation, cytotoxicity, mutation and cytogenetic effects in Syrian hamster embryo cells in culture.
Topics: Animals; Arsenates; Arsenic; Arsenites; Cell Survival; Cell Transformation, Neoplastic; Cells, Cultured; Chromosome Aberrations; Cricetinae; Drug Resistance; Mutation; Ouabain; Sister Chromatid Exchange; Sodium Compounds; Thioguanine | 1985 |
Arsenic as an inhibitor of the enzymes concerned in cellular recovery (dark repair).
Topics: Adult; Animals; Arsenic; Autoradiography; Cell Transformation, Neoplastic; Enzyme Repression; Humans; In Vitro Techniques; Male; Radiation Injuries, Experimental; Skin; Skin Neoplasms; Skin Transplantation; Transplantation, Homologous; Tritium | 1969 |