Page last updated: 2024-08-26

arsenic and melarsoprol

arsenic has been researched along with melarsoprol in 74 studies

Research

Studies (74)

Timeframe	Studies, this research(%)	All Research%
pre-1990	47 (63.51)	18.7374
1990's	14 (18.92)	18.2507
2000's	10 (13.51)	29.6817
2010's	3 (4.05)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Aiyedun, BA; Amodu, AA	1
Blair, LS; Campbell, WC	1
Foulkes, JR	1
Buyst, H	1
Bacchi, CJ; Garofalo, J; Goldberg, B; Nathan, HC; Yarlett, N	1
Astier, A; Brun-Buisson, C; Chariot, P; Gherardi, RK; Malapert, D; Schaeffer, A; Vanderstigel, M; Verroust, J	1
Bales, JD; Harrison, SM; Mbwabi, DL; Schecter, PJ	1
Ethier, L; Guern, C; Mansinsa, D; Milord, F; Mpia, B; Pepin, J	1
Baeriswyl, S; Brun, R; Kunz, C	1
Chumo, DA; Muriithi, RM; Mwangi, J; Reardon, MJ; Towett, S; Wellde, BT	1
Abinya, A; Chumo, DA; Dola, S; Mbwabi, D; Reardon, MJ; Siongok, TA; Smith, DH; Wanyama, L; Wellde, BT	1
Dolmans, WM; Ebeling, MC; Veeken, HJ	1
Jennings, FW	3
Guern, C; Milord, F; Pepin, J; Schechter, PJ	1
Coombs, GH; Mottram, JC	1
Kazyumba, GL; Nkanga, N; Ruppol, JF; Tshefu, AK	1
Breton, JC; Dumas, M; Giordano, C; Girard, PL; Pestre Alexandre, M	1
Frommel, TO	1
Akani, F; Boa, FY; Giordano, C; Kouassi, B; Piquemal, M; Sonan, T; Yapi, P	1
Bouteille, B; Darde, ML; Monteil, J; Pestre-Alexandre, M	1
Bouteille, B; Breton, JC; Catanzano, G; Darde, ML; Dumas, M; Munoz, M; Nicolas, JA; Pestre-Alexandre, M	1
Kernbaum, S; Pialoux, G; Vachon, F	1
Doua, F; Hamers, R; Maes, L	1
Cattand, P; Doua, F; Hamers, R; Maes, L; Vanderveken, M	1
Scena, MR	1
Corachán, M; Estruch, R; Grau Junyent, JM; Rozman, M; Urbano-Marquez, A	1
Arroz, JO	1
Adams, H; Dago, A; Haller, L; Merouze, F	1
Dukes, P	1
Breton, JC; Catanzano, G; Dumas, M; Nicolas, JA; Pestre-Alexandre, M	1
Hochmann, A; Lambert, PH; Poltera, AA	1
Hall, JE; Seed, JR; Shertzer, HG	1
Boa Yapo, F; Doua, F	1
Carter, NS; Fairlamb, AH	1
Scott, AG; Tait, A; Turner, CM	2
Barrett, MP; Bertelli, M; Dallocchio, F; Hanau, S; Rippa, M	1
Atouguia, JM; Jennings, FW; Murray, M	1
Gabrilove, JL; Jakubowski, A; König, A; Pandolfi, PP; Rivi, R; Warrell, RP; Wrazel, L	1
Bales, JD; Harris, RW; Harrison, SM	1
Delva, L; Gabrilove, JL; Gambacorti-Passerini, C; König, A; Pandolfi, PP; Rivi, R; Scheinberg, DA; Wang, ZG; Warrell, RP	1
Brouet, JC; Fermand, JP; Labaume, S; Larghero, J; Marolleau, JP; Noguera, MH; Rousselot, P	1
Barrett, MP; Cover, B; de Koning, HP; Jarvis, SM; MacLeod, A	1
Gregus, Z; Gyurasics, A	1
Burri, C; Ericsson, O; Keiser, J	1
Warrell, RP	1
Legros, D; Ollivier, G	1
CECCALDI, J	1
NEUJEAN, G	1
APTED, FI	1
PINTO, AR	1
MICHIELSEN, P; TRIEST, A	1
CARMO, RP; CASEIRO, A; DE BASTO, AX; SILVA, MA	1
EVENS, F; LAMBOTTE, C; LEGRAND, J	1
BURKE, J	1
NIXON, LC; TAUBE, E	1
DE JONGH, RT; FRIEDHEIM, EA	1
HAWKING, F	1
ROBERTSON, DH	2
Barrett, MP; Brun, R; Burchmore, RJ; de Koning, HP; Enyaru, JC; Geiser, F; Kaminsky, R; Mäser, P; Matovu, E; Seebeck, T; Stewart, ML; Wallace, LJ	1
FRIEDHEIM, EA	1
de ALMEIDA, CL; FERREIRA, FS; PIRES, FM	1
Brouet, JC; Chopin, M; Dosquet, C; Fermand, JP; Janin, A; Labaume, S; Larghero, J; Marolleau, JP; Poupon, J; Rousselot, P	1
Bajenova, O; Childs, BH; Feinman, R; Michaeli, J; Pearse, R; Tang, B	1
Schweingruber, ME	1
Alibu, VP; Brun, R; Clayton, C; Marti, G; Renggli, CK; Richter, C; Seebeck, T; Shahi, S; Voncken, F	1
Ajana, I; Astier, A; Gibaud, S	1
Baumann, A; Karst, U; Melles, D; Pfeifer, T	1
Aniceto, N; Astier, A; Becherirat, S; Gibaud, S; Lanhers, MC; Loboda, C; Socha, M; Yemloul, M	1
Francesconi, KA; Magnes, C; Murko, M; Raber, G; Raber, T; Raml, R	1

Reviews

2 review(s) available for arsenic and melarsoprol

Article	Year
Combination chemotherapy of CNS trypanosomiasis. Acta tropica, 1993, Volume: 54, Issue:3-4 Topics: Arsenicals; Central Nervous System Diseases; Drug Therapy, Combination; Humans; Melarsoprol; Nitroimidazoles; Trypanocidal Agents; Trypanosomiasis, African	1993
Arsenicals and inhibitors of histone deacetylase as anticancer therapy. Haematologica, 1999, Volume: 84 Suppl EHA-4 Topics: Acetylation; Adult; Antineoplastic Agents; Arsenic Trioxide; Arsenicals; Child; China; Chromatin; Drug Evaluation; Drug Resistance, Neoplasm; Enzyme Inhibitors; Gastrointestinal Diseases; Histone Deacetylase Inhibitors; Humans; Leukemia, Promyelocytic, Acute; Leukocytosis; Melarsoprol; Neoplasm Proteins; Neoplasms; Nervous System Diseases; Oxides; Phenylbutyrates; Protein Processing, Post-Translational; Salvage Therapy; Tretinoin	1999

Article

Year

Combination chemotherapy of CNS trypanosomiasis.

Acta tropica, 1993, Volume: 54, Issue:3-4

Topics: Arsenicals; Central Nervous System Diseases; Drug Therapy, Combination; Humans; Melarsoprol; Nitroimidazoles; Trypanocidal Agents; Trypanosomiasis, African

1993

Arsenicals and inhibitors of histone deacetylase as anticancer therapy.

Haematologica, 1999, Volume: 84 Suppl EHA-4

Topics: Acetylation; Adult; Antineoplastic Agents; Arsenic Trioxide; Arsenicals; Child; China; Chromatin; Drug Evaluation; Drug Resistance, Neoplasm; Enzyme Inhibitors; Gastrointestinal Diseases; Histone Deacetylase Inhibitors; Humans; Leukemia, Promyelocytic, Acute; Leukocytosis; Melarsoprol; Neoplasm Proteins; Neoplasms; Nervous System Diseases; Oxides; Phenylbutyrates; Protein Processing, Post-Translational; Salvage Therapy; Tretinoin

1999

Trials

3 trial(s) available for arsenic and melarsoprol

Article	Year
Trial of prednisolone for prevention of melarsoprol-induced encephalopathy in gambiense sleeping sickness. Lancet (London, England), 1989, Jun-03, Volume: 1, Issue:8649 Topics: Administration, Oral; Adolescent; Adult; Aged; Animals; Arsenicals; Child; Child, Preschool; Clinical Trials as Topic; Coma; Female; Follow-Up Studies; Humans; Infant; Infant, Newborn; Leukocyte Count; Male; Melarsoprol; Middle Aged; Prednisolone; Prognosis; Prospective Studies; Random Allocation; Sex Factors; Trypanosoma brucei gambiense; Trypanosomiasis, African	1989
[Current status of the therapy of human African trypanosomiasis]. Presse medicale (Paris, France : 1983), 1985, Feb-09, Volume: 14, Issue:5 Topics: Animals; Arsenicals; Clinical Trials as Topic; Glycolysis; Humans; Lipid Metabolism; Melarsoprol; Proteins; Trypanocidal Agents; Trypanosoma; Trypanosomiasis, African; Vaccines	1985
Attempt to correlate urine arsenic excretion with clinical course during melarsoprol therapy of patients with Rhodesian trypanosomiasis. The American journal of tropical medicine and hygiene, 1997, Volume: 56, Issue:6 Topics: Adolescent; Adult; Aged; Animals; Arsenic; Child; Child, Preschool; Creatinine; Drug Therapy, Combination; Female; Humans; Male; Melarsoprol; Middle Aged; Suramin; Treatment Outcome; Trypanocidal Agents; Trypanosoma brucei rhodesiense; Trypanosomiasis, African	1997

Other Studies

69 other study(ies) available for arsenic and melarsoprol

Article	Year
Mel B toxicity in human trypanosomiasis in the Gboko endemic area of Nigeria. Acta tropica, 1976, Volume: 33, Issue:1 Topics: Adolescent; Adult; Arsenicals; Child; Diarrhea; Female; Fever; Humans; Male; Melarsoprol; Nigeria; Seizures; Trypanosomiasis, African	1976
Chemotherapy of sleeping sickness. The Central African journal of medicine, 1979, Volume: 25, Issue:11 Topics: Arsenicals; Humans; Melarsoprol; Pentamidine; Suramin; Trypanosomiasis, African	1979
Trial of avermectin B1a, mebendazole and melarsoprol against pre-cardiac Dirofilaria immitis in the ferret (Mustela putorius furo). The Journal of parasitology, 1978, Volume: 64, Issue:6 Topics: Animals; Antinematodal Agents; Arsenicals; Benzimidazoles; Dirofilariasis; Female; Ferrets; Mebendazole; Melarsoprol	1978
An evaluation of prednisolone as a routine adjunct to the treatment of T. rhodesiense. The Journal of tropical medicine and hygiene, 1975, Volume: 78, Issue:4 Topics: Adult; Arsenicals; Child; Drug Administration Schedule; Drug Evaluation, Preclinical; Humans; Melarsoprol; Meningoencephalitis; Prednisolone; Suramin; Trypanosoma; Trypanosomiasis, African; Zambia	1975
The treatment of T. rhodesiense sleeping sickness, with special reference to its physio-pathological and epidemiological basis. Annales de la Societe belge de medecine tropicale, 1975, Volume: 55, Issue:2 Topics: Arsenicals; Chloroquine; Humans; Melarsoprol; Proguanil; Suramin; Trypanosomiasis, African; Zambia	1975
Differential sensitivity of Trypanosoma brucei rhodesiense isolates to in vitro lysis by arsenicals. Experimental parasitology, 1991, Volume: 72, Issue:2 Topics: Animals; Arsenicals; Calcium; Calcium Channels; Drug Resistance; Female; Melarsoprol; Mice; Sulfhydryl Compounds; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African	1991
Organic arsenic-induced Guillain-Barré-like syndrome due to melarsoprol: a clinical, electrophysiological, and pathological study. Muscle & nerve, 1990, Volume: 13, Issue:7 Topics: Adult; Arsenic; Arsenic Poisoning; Arsenicals; Diagnosis, Differential; Electrophysiology; Female; Humans; Melarsoprol; Peripheral Nervous System Diseases; Polyradiculoneuropathy; Trypanosomiasis	1990
Treatment of arsenical refractory Rhodesian sleeping sickness in Kenya. Annals of tropical medicine and parasitology, 1989, Volume: 83 Suppl 1 Topics: Adult; Animals; Arsenicals; Drug Therapy, Combination; Eflornithine; Female; Humans; Kenya; Male; Melarsoprol; Middle Aged; Recurrence; Suramin; Trypanosoma brucei brucei; Trypanosomiasis, African	1989
In vitro drug sensitivity of Trypanosoma gambiense isolates. Acta tropica, 1989, Volume: 46, Issue:5-6 Topics: Animals; Arsenicals; Cote d'Ivoire; Humans; Melarsoprol; Pentamidine; Suramin; Trypanocidal Agents; Trypanosoma brucei gambiense; Trypanosomiasis, African	1989
Experimental infection of goats with Trypanosoma brucei ssp. and effects of treatment with suramin and Mel-B. Annals of tropical medicine and parasitology, 1989, Volume: 83 Suppl 1 Topics: Animals; Arsenicals; Brain; Central Nervous System; Central Nervous System Diseases; Goat Diseases; Goats; Male; Melarsoprol; Mice; Spinal Puncture; Suramin; Trypanocidal Agents; Trypanosomiasis, African	1989
Treatment of Rhodesian sleeping sickness in Kenya. Annals of tropical medicine and parasitology, 1989, Volume: 83 Suppl 1 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Animals; Arsenicals; Child; Drug Resistance; Female; Follow-Up Studies; Humans; Kenya; Male; Melarsoprol; Middle Aged; Prospective Studies; Recurrence; Retrospective Studies; Suramin; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African	1989
Trypanosomiasis in a rural hospital in Tanzania. A retrospective study of its management and the results of treatment. Tropical and geographical medicine, 1989, Volume: 41, Issue:2 Topics: Animals; Arsenicals; Female; Follow-Up Studies; Humans; Male; Melarsoprol; Retrospective Studies; Rural Population; Tanzania; Trypanosoma brucei brucei; Trypanosomiasis, African	1989
The potentiation of arsenicals with difluoromethylornithine (DFMO): experimental studies in murine trypanosomiasis. Bulletin de la Societe de pathologie exotique et de ses filiales, 1988, Volume: 81, Issue:3 Pt 2 Topics: Animals; Antimony Sodium Gluconate; Arsenicals; Drug Synergism; Drug Therapy, Combination; Eflornithine; Melarsoprol; Mice; Mitoguazone; Trypanosoma brucei brucei; Trypanosomiasis, African	1988
Difluoromethylornithine for arseno-resistant Trypanosoma brucei gambiense sleeping sickness. Lancet (London, England), 1987, Dec-19, Volume: 2, Issue:8573 Topics: Administration, Oral; Adolescent; Animals; Arsenicals; Child; Child, Preschool; Diarrhea; Drug Resistance; Eflornithine; Female; Follow-Up Studies; Humans; Infusions, Intravenous; Male; Melarsoprol; Recurrence; Trypanosoma brucei gambiense; Trypanosomiasis, African	1987
Leishmania mexicana: enzyme activities of amastigotes and promastigotes and their inhibition by antimonials and arsenicals. Experimental parasitology, 1985, Volume: 59, Issue:2 Topics: Animals; Antimony; Antimony Sodium Gluconate; Antiprotozoal Agents; Arsenicals; Citric Acid Cycle; Gluconates; Glycolysis; Hexokinase; Leishmania; Malate Dehydrogenase; Melarsoprol; Organometallic Compounds; Phosphoenolpyruvate Carboxykinase (GTP); Phosphofructokinase-1; Pyruvate Kinase; Triazines	1985
[Arsenical resistance and difluoromethylornithine in the treatment of human African trypanosomiasis]. Bulletin de la Societe de pathologie exotique et de ses filiales, 1988, Volume: 81, Issue:3 Pt 2 Topics: Arsenicals; Drug Resistance; Eflornithine; Humans; Melarsoprol; Trypanosomiasis, African	1988
Chemotherapy of trypanosomiasis: the potentiation of melarsoprol by concurrent difluoromethylornithine (DFMO) treatment. Transactions of the Royal Society of Tropical Medicine and Hygiene, 1988, Volume: 82, Issue:4 Topics: Animals; Arsenicals; Chagas Disease; Drug Synergism; Drug Therapy, Combination; Eflornithine; Melarsoprol; Mice; Trypanosoma brucei brucei	1988
Trypanosoma brucei rhodesiense: effect of immunosuppression on the efficacy of melarsoprol treatment of infected mice. Experimental parasitology, 1988, Volume: 67, Issue:2 Topics: Animals; Arsenicals; Cyclophosphamide; Immunosuppression Therapy; Male; Melarsoprol; Mice; Mice, Inbred C3H; Trypanosoma brucei brucei; Trypanosomiasis, African	1988
[EEG and treatment with Arsobal in human African trypanosomiasis]. Bulletin de la Societe de pathologie exotique et de ses filiales, 1988, Volume: 81, Issue:3 Pt 2 Topics: Animals; Arsenicals; Electroencephalography; Humans; Melarsoprol; Trypanosoma brucei gambiense; Trypanosomiasis, African	1988
[Complement: a sign of infestation of sheep by Trypanosoma brucei brucei in an experimental model: its evolution following treatment]. Bulletin de la Societe de pathologie exotique et de ses filiales, 1988, Volume: 81, Issue:3 Pt 2 Topics: Animals; Arsenicals; Complement System Proteins; Disease Models, Animal; Melarsoprol; Sheep; Trypanosoma brucei brucei; Trypanosomiasis, African	1988
[Treatment of experimental trypanosomiasis caused by Trypanosoma brucei brucei in sheep: study of the minimum active dose of melarsoprol]. Bulletin de la Societe de pathologie exotique et de ses filiales, 1988, Volume: 81, Issue:3 Pt 2 Topics: Animals; Arsenicals; Injections, Intravenous; Melarsoprol; Sheep; Trypanosoma brucei brucei; Trypanosomiasis, African	1988
[Arsenical-induced encephalopathy during the treatment of African trypanosomiasis. Apropos of a case with a favorable outcome]. Bulletin de la Societe de pathologie exotique et de ses filiales, 1988, Volume: 81, Issue:3 Pt 2 Topics: Adult; Animals; Arsenicals; Brain Diseases; Humans; Male; Melarsoprol; Trypanosoma brucei gambiense; Trypanosomiasis, African	1988
ELISA assay for melarsoprol. Bulletin de la Societe de pathologie exotique et de ses filiales, 1988, Volume: 81, Issue:3 Pt 2 Topics: Arsenicals; Enzyme-Linked Immunosorbent Assay; Humans; Melarsoprol; Methods; Trypanocidal Agents	1988
The monitoring of trypanocidal treatment with a sensitive ELISA method for measuring melarsoprol levels in serum and in cerebrospinal fluids. Annales de la Societe belge de medecine tropicale, 1988, Volume: 68, Issue:3 Topics: Arsenicals; Chemical Phenomena; Chemistry; Enzyme-Linked Immunosorbent Assay; Humans; In Vitro Techniques; Melarsoprol; Spectrophotometry, Atomic; Trypanosomiasis, African	1988
Melarsoprol toxicity in the treatment of human African trypanosomiasis. Ten cases treated with dimercaprol. The Central African journal of medicine, 1988, Volume: 34, Issue:11 Topics: Adolescent; Adult; Arsenicals; Central Nervous System Diseases; Dimercaprol; Female; Humans; Male; Melarsoprol; Middle Aged; Trypanosomiasis, African	1988
An unusual course of west African trypanosomiasis in a Caucasian man. Transactions of the Royal Society of Tropical Medicine and Hygiene, 1987, Volume: 81, Issue:6 Topics: Adult; Arsenicals; Heart Block; Humans; Male; Melarsoprol; Polyradiculoneuropathy; Trypanosomiasis, African	1987
Melarsoprol and reactive encephalopathy in Trypanosoma brucei rhodesiense. Transactions of the Royal Society of Tropical Medicine and Hygiene, 1987, Volume: 81, Issue:2 Topics: Arsenicals; Brain Diseases; Humans; Melarsoprol; Trypanosoma brucei brucei; Trypanosomiasis, African	1987
Clinical and pathological aspects of human African trypanosomiasis (T. b. gambiense) with particular reference to reactive arsenical encephalopathy. The American journal of tropical medicine and hygiene, 1986, Volume: 35, Issue:1 Topics: Animals; Arsenicals; Brain Diseases; Humans; Melarsoprol; Seizures; Trypanosoma brucei gambiense; Trypanosomiasis, African	1986
Arsenic and old taxa: subspeciation and drug sensitivity in Trypanosoma brucei. Transactions of the Royal Society of Tropical Medicine and Hygiene, 1984, Volume: 78, Issue:6 Topics: Animals; Arsenicals; Diminazene; Dose-Response Relationship, Drug; Drug Resistance, Microbial; Isoenzymes; Male; Melarsoprol; Mice; Pentamidine; Suramin; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African	1984
[Treatment of human African trypanosomiasis]. Bulletin de la Societe de pathologie exotique et de ses filiales, 1983, Volume: 76, Issue:5 Topics: Arsenicals; Humans; Melarsoprol; Rifamycins; Trypanosomiasis, African	1983
Trypanosoma brucei brucei: the response to Melarsoprol in mice with cerebral trypanosomiasis. An immunopathological study. Clinical and experimental immunology, 1981, Volume: 46, Issue:2 Topics: Animals; Antigen-Antibody Complex; Arsenicals; Brain; Brain Diseases; Chloroquine; Fluorescent Antibody Technique; Injections, Intraperitoneal; Injections, Intravenous; Melarsoprol; Mice; Nitroimidazoles; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African	1981
Hepatic mixed-function oxidase activity in mice infected with Trypanosoma brucei gambiense or treated with trypanocides. Molecular and biochemical parasitology, 1981, Volume: 3, Issue:4 Topics: Animals; Arsenicals; Cytochrome P-450 Enzyme System; Liver; Male; Melarsoprol; Mice; Mixed Function Oxygenases; Oxidoreductases; Pentobarbital; Sleep; Suramin; Trypanosoma brucei brucei; Trypanosomiasis, African	1981
[Current therapy of trypanosomiasis]. Bulletin de la Societe de pathologie exotique (1990), 1994, Volume: 87, Issue:5 Topics: Adenosylmethionine Decarboxylase; Animals; Arsenicals; Deoxyadenosines; Drug Resistance; Eflornithine; Enzyme Inhibitors; Hospitalization; Humans; Melarsoprol; Pentamidine; Randomized Controlled Trials as Topic; Recurrence; Suramin; Triazines; Trypanocidal Agents; Trypanosomiasis, African	1994
Arsenical-resistant trypanosomes lack an unusual adenosine transporter. Nature, 1993, Jan-14, Volume: 361, Issue:6408 Topics: Adenine; Adenosine; Animals; Antiprotozoal Agents; Arsenicals; Biological Transport; Carrier Proteins; Drug Resistance; Inosine; Kinetics; Melarsoprol; Trypanosoma brucei brucei	1993
Characterisation of cloned lines of Trypanosoma brucei expressing stable resistance to MelCy and suramin. Acta tropica, 1996, Volume: 60, Issue:4 Topics: Animals; Arsenicals; Biological Assay; Cells, Cultured; Clone Cells; Drug Resistance; Female; Male; Melarsoprol; Mice; Mice, Inbred BALB C; Phenotype; Suramin; Trypanocidal Agents; Trypanosoma brucei brucei	1996
6-Phosphogluconate dehydrogenase from Trypanosoma brucei. Kinetic analysis and inhibition by trypanocidal drugs. European journal of biochemistry, 1996, Sep-15, Volume: 240, Issue:3 Topics: Animals; Arsenicals; Enzyme Inhibitors; Hydrogen-Ion Concentration; Kinetics; Liver; Melarsoprol; Phosphogluconate Dehydrogenase; Sheep; Species Specificity; Suramin; Trypanocidal Agents; Trypanosoma brucei brucei	1996
The importance of 2,3-dimercaptopropinol (British anti-lewisite, BAL) in the trypanocidal activity of topical melarsoprol. Acta tropica, 1996, Volume: 62, Issue:2 Topics: Administration, Topical; Animals; Arsenicals; Dimercaprol; Drug Combinations; Female; Gels; Melarsoprol; Mice; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African	1996
Trypanosoma brucei: lack of cross-resistance to melarsoprol in vitro by cymelarsan-resistant parasites. Experimental parasitology, 1997, Volume: 86, Issue:3 Topics: Adenine; Adenosine; Animals; Arsenicals; Diminazene; Dose-Response Relationship, Drug; Drug Resistance; Enzyme Inhibitors; Female; Inosine; Melarsoprol; Mice; Pentamidine; Trypanocidal Agents; Trypanosoma brucei brucei	1997
Comparative activity of melarsoprol and arsenic trioxide in chronic B-cell leukemia lines. Blood, 1997, Jul-15, Volume: 90, Issue:2 Topics: Antineoplastic Agents; Apoptosis; Arsenic Poisoning; Arsenic Trioxide; Arsenicals; Cell Division; Cell Line, Transformed; Cell Survival; DNA Damage; DNA Fragmentation; Drug Screening Assays, Antitumor; Herpesvirus 4, Human; Humans; Kinetics; Leukemia, Lymphocytic, Chronic, B-Cell; Melarsoprol; Oxides; Proto-Oncogene Proteins c-bcl-2; RNA, Messenger; Time Factors; Transcription, Genetic; Tumor Cells, Cultured	1997
Arsenic trioxide and melarsoprol induce programmed cell death in myeloid leukemia cell lines and function in a PML and PML-RARalpha independent manner. Blood, 1998, Sep-01, Volume: 92, Issue:5 Topics: Animals; Antineoplastic Agents; Apoptosis; Arsenic Trioxide; Arsenicals; Bone Marrow Cells; Cell Division; Embryo, Mammalian; Fibroblasts; Gene Expression Regulation; Humans; Leukemia, Myeloid; Leukemia, Promyelocytic, Acute; Melarsoprol; Mice; Neoplasm Proteins; Nuclear Proteins; Oxides; Promyelocytic Leukemia Protein; Proto-Oncogene Proteins c-bcl-2; Receptors, Retinoic Acid; Transcription Factors; Tumor Cells, Cultured; Tumor Suppressor Proteins	1998
Arsenic trioxide and melarsoprol induce apoptosis in plasma cell lines and in plasma cells from myeloma patients. Cancer research, 1999, Mar-01, Volume: 59, Issue:5 Topics: Antineoplastic Agents; Apoptosis; Arsenic Poisoning; Arsenic Trioxide; Arsenicals; Cell Division; Cell Line; Cell Survival; Flow Cytometry; Fluorescent Antibody Technique, Indirect; Humans; Kinetics; Lymphocyte Activation; Melarsoprol; Multiple Myeloma; Neoplasm Proteins; Nuclear Proteins; Oxides; Plasma Cells; Promyelocytic Leukemia Protein; Transcription Factors; Tumor Suppressor Proteins	1999
Further evidence for a link between melarsoprol resistance and P2 transporter function in African trypanosomes. Molecular and biochemical parasitology, 2000, Feb-25, Volume: 106, Issue:1 Topics: Animals; Antiprotozoal Agents; Arsenicals; Biological Transport, Active; Dose-Response Relationship, Drug; Drug Resistance; Melarsoprol; Mice; Mice, Inbred BALB C; Minisatellite Repeats; Purines; Trypanocidal Agents; Trypanosoma brucei brucei	2000
Role of glutathione in the biliary excretion of the arsenical drugs trimelarsan and melarsoprol. Biochemical pharmacology, 2000, Jun-01, Volume: 59, Issue:11 Topics: Animals; Arsenic; Arsenicals; Biliary Tract; Glucuronic Acid; Glutathione; Liver; Male; Melarsoprol; Rats; Rats, Wistar; Trypanocidal Agents	2000
Investigations of the metabolites of the trypanocidal drug melarsoprol. Clinical pharmacology and therapeutics, 2000, Volume: 67, Issue:5 Topics: Adult; Animals; Area Under Curve; Arsenic; Arsenicals; Biological Assay; Chromatography, High Pressure Liquid; Disease Models, Animal; Drug Interactions; Female; Humans; Male; Melarsoprol; Mice; Mice, Inbred Strains; Microsomes, Liver; Spectrophotometry, Atomic; Trypanocidal Agents; Trypanosoma brucei gambiense; Trypanosomiasis, African	2000
[Human african trypanosomiasis: A history of its therapies and their failures]. Tropical medicine & international health : TM & IH, 2001, Volume: 6, Issue:11 Topics: Arsenicals; Drug Resistance; History, 20th Century; History, 21st Century; Humans; Melarsoprol; Pentamidine; Treatment Outcome; Trypanocidal Agents; Trypanosomiasis, African	2001
[New contribution on arsobal (R.P. 3854) therapy of trypanosomiasis; its effectiveness in former trypanosomiasis patients, with meningoencephalitis, resistant to trypanocides customarily used]. Bulletin de la Societe de pathologie exotique et de ses filiales, 1953, Volume: 46, Issue:1 Topics: Animals; Arsenicals; Humans; Melarsoprol; Meningoencephalitis; Trypanocidal Agents; Trypanosomiasis	1953
[Use of arsobal in the treatment of sleeping sickness]. Anais do Instituto de Medicina Tropical, 1952, Volume: 9, Issue:3 Topics: Animals; Arsenicals; Black People; Humans; Melarsoprol; Trypanosomiasis; Trypanosomiasis, African	1952
The treatment of advanced cases of Rhodesian sleeping sickness by Mel. B. and arsobal. Transactions of the Royal Society of Tropical Medicine and Hygiene, 1953, Volume: 47, Issue:5 Topics: Animals; Arsenicals; Black People; Humans; Melarsoprol; Trypanosomiasis; Trypanosomiasis, African	1953
The therapeutic effect on a group of sleeping sickness patients of a single injection of 3854 R.P. (mel B Friedheim-arsobal Spécia). The American journal of tropical medicine and hygiene, 1954, Volume: 3, Issue:3 Topics: Animals; Arsenicals; Humans; Melarsoprol; Trypanosomiasis; Trypanosomiasis, African	1954
[Toxic effects of arsobal on the cardiovascular system]. Annales de la Societe belge de medecine tropicale (1920), 1954, Aug-31, Volume: 34, Issue:4 Topics: Arsenicals; Cardiovascular System; Humans; Melarsoprol	1954
Arsobal in the treatment of Rhodesian sleeping-sickness. Anais do Instituto de Medicina Tropical, 1954, Volume: 11, Issue:2 Topics: Animals; Arsenicals; Humans; Melarsoprol; Trypanosomiasis; Trypanosomiasis, African	1954
[A case of trypanosomiasis in an infant treated with arsobal]. Annales de la Societe belge de medecine tropicale (1920), 1956, Oct-31, Volume: 36, Issue:5 Topics: Animals; Arsenicals; Child; Humans; Infant; Melarsoprol; Trypanosomiasis	1956
[Study of the therapeutic value of arsobal in trypanosomiasis caused by Trypanosoma gambiense]. Annales de la Societe belge de medecine tropicale (1920), 1957, Apr-30, Volume: 37, Issue:2 Topics: Animals; Arsenicals; Black People; Humans; Melarsoprol; Trypanosoma brucei gambiense; Trypanosomiasis; Trypanosomiasis, African	1957
The treatment of advanced trypanosomiasis rhodesiense with mel B. The Central African journal of medicine, 1958, Volume: 4, Issue:4 Topics: Animals; Arsenicals; Black People; Humans; Melarsoprol; Trypanosomiasis; Trypanosomiasis, African	1958
Mel W, a new trypanosomicidal agent derived from mel B. Transactions of the Royal Society of Tropical Medicine and Hygiene, 1959, Volume: 53, Issue:3 Topics: Arsenicals; Humans; Melarsoprol; Trypanocidal Agents; Trypanosomiasis	1959
Estimation of the concentration of melarsoprol (Mel B) and Mel W in biological fluids by bioassay with trypanosomes in vitro. Transactions of the Royal Society of Tropical Medicine and Hygiene, 1962, Volume: 56 Topics: Arsenicals; Biological Assay; Blood; Cerebrospinal Fluid; Humans; In Vitro Techniques; Melarsoprol; Trypanosoma	1962
The treatment of sleeping sickness (mainly due to Trypanosoma rhodesiense) with melarsoprol. I. Reactions observed during treatment. Transactions of the Royal Society of Tropical Medicine and Hygiene, 1963, Volume: 57 Topics: Animals; Arsenicals; Dimercaprol; Humans; Melarsoprol; Trypanosoma brucei rhodesiense; Trypanosomiasis; Trypanosomiasis, African	1963
The treatment of sleeping sickness (mainly due to Trypanosoma rhodesiense) with melarsoprol. Transactions of the Royal Society of Tropical Medicine and Hygiene, 1963, Volume: 57 Topics: Animals; Arsenicals; Dimercaprol; Humans; Melarsoprol; Trypanosoma brucei rhodesiense; Trypanosomiasis; Trypanosomiasis, African	1963
Mechanisms of arsenical and diamidine uptake and resistance in Trypanosoma brucei. Eukaryotic cell, 2003, Volume: 2, Issue:5 Topics: Adenine; Adenosine; Animals; Arsenicals; Benzamidines; Cell Death; Cell Division; Diminazene; Drug Resistance; Female; Gene Silencing; Hypoxanthine; Inhibitory Concentration 50; Inosine; Melarsoprol; Mice; Mutation; Nucleoside Transport Proteins; Pentamidine; Stilbamidines; Trypanosoma brucei brucei	2003
Mel B in the treatment of tryparsamide resistant T. gambiense sleeping sickness: observations on drug resistance in the trypanosomes of the French Cameroun. The American journal of tropical medicine and hygiene, 1951, Volume: 31, Issue:2 Topics: Animals; Arsenic; Arsenicals; Drug Resistance; Humans; Melarsoprol; Trypanosomiasis; Trypanosomiasis, African	1951
[First results of the treatment of human trypanosomiasis with Mel B]. Anais do Instituto de Medicina Tropical, 1950, Volume: 7 Topics: Arsenic; Humans; Melarsoprol; Trypanosomiasis	1950
Arsenic trioxide is effective in the treatment of multiple myeloma in SCID mice. European journal of haematology, 2004, Volume: 72, Issue:3 Topics: Animals; Arsenic Trioxide; Arsenicals; Cell Division; Humans; Immunoglobulin G; Melarsoprol; Mice; Mice, SCID; Multiple Myeloma; Neoplasm Transplantation; Neoplasms, Experimental; Oxides; Plasma Cells; Receptors, Interleukin-6; Survival Analysis; Tissue Distribution; Xenograft Model Antitumor Assays	2004
RIP kinase is involved in arsenic-induced apoptosis in multiple myeloma cells. Apoptosis : an international journal on programmed cell death, 2004, Volume: 9, Issue:5 Topics: Apoptosis; Arsenic; Caspase 3; Caspases; Cell Division; Cell Line, Tumor; Cell Survival; Enzyme Activation; Humans; Melarsoprol; Multiple Myeloma; NF-kappa B	2004
The melaminophenyl arsenicals melarsoprol and melarsen oxide interfere with thiamine metabolism in the fission yeast Schizosaccharomyces pombe. Antimicrobial agents and chemotherapy, 2004, Volume: 48, Issue:9 Topics: Arsenicals; Culture Media; Melarsoprol; Mutation; Oxides; Pyrimidines; Schizosaccharomyces; Thiamine; Trypanocidal Agents	2004
The role of Trypanosoma brucei MRPA in melarsoprol susceptibility. Molecular and biochemical parasitology, 2006, Volume: 146, Issue:1 Topics: Animals; Arsenicals; Blotting, Western; Cell Line; Electrophoresis, Polyacrylamide Gel; Female; Gene Expression; Humans; Melarsoprol; Membrane Transport Proteins; Mice; Multidrug Resistance-Associated Proteins; Parasitic Sensitivity Tests; Protozoan Proteins; Reverse Transcriptase Polymerase Chain Reaction; Treatment Failure; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African	2006
Arsthinol nanosuspensions: pharmacokinetics and anti-leukaemic activity on NB4 promyelocytic leukaemia cells. The Journal of pharmacy and pharmacology, 2009, Volume: 61, Issue:10 Topics: Animals; Antineoplastic Agents; Arsenic Trioxide; Arsenicals; Bone Marrow; Brain; Cell Line, Tumor; Cell Proliferation; Drug Screening Assays, Antitumor; Female; Humans; Melarsoprol; Mice; Mice, Inbred Strains; Nanotechnology; Oxides; Suspensions	2009
Investigation of the biotransformation of melarsoprol by electrochemistry coupled to complementary LC/ESI-MS and LC/ICP-MS analysis. Analytical and bioanalytical chemistry, 2013, Volume: 405, Issue:15 Topics: Arsenicals; Chromatography, Liquid; Hemoglobins; Humans; Mass Spectrometry; Melarsoprol; Molecular Structure; Protein Binding; Serum Albumin; Trypanocidal Agents	2013
The antitumor effects of an arsthinol-cyclodextrin complex in a heterotopic mouse model of glioma. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 2013, Volume: 85, Issue:3 Pt A Topics: 2-Hydroxypropyl-beta-cyclodextrin; Animals; Antineoplastic Agents; Arsenic Trioxide; Arsenicals; beta-Cyclodextrins; Brain Neoplasms; Cell Line, Tumor; Excipients; Female; Glioma; Humans; Injections, Intraperitoneal; Magnetic Resonance Spectroscopy; Melarsoprol; Mice; Mice, Nude; Oxides; Xenograft Model Antitumor Assays	2013
Determination of the trypanocidal drug melarsoprol and its conversion products in biological fluids with HPLC-ICPMS/ESMS. Talanta, 2013, Nov-15, Volume: 116 Topics: Arsenic; Arsenicals; Biotransformation; Blood Cells; Blood Proteins; Cells, Cultured; Chromatography, High Pressure Liquid; Drug Stability; Humans; Limit of Detection; Melarsoprol; Protein Binding; Serum; Spectrometry, Mass, Electrospray Ionization; Spectrophotometry, Atomic; Trypanocidal Agents	2013