Compounds > arsenic
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arsenic and acetylcysteine

arsenic has been researched along with acetylcysteine in 56 studies

Research

Studies (56)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's4 (7.14)18.2507
2000's25 (44.64)29.6817
2010's26 (46.43)24.3611
2020's1 (1.79)2.80

Authors

AuthorsStudies
Batres, L; Carrizales, L; Díaz-Barriga, F; Mejía, J; Ortíz, D; Ramos, O; Yáñez, L1
Brigelius-Flohé, R; Friedrichs, B; Müller, C1
Dai, J; Jing, Y; Waxman, S; Weinberg, RS1
Bonkovsky, HL; Hong Lu, T; Lambrecht, RW; Shan, Y1
Bahlis, NJ; Boise, LH; Dalton, WS; Grad, JM; Oshiro, MM; Reis, I1
Bai, H; Lu, JH; Ou, YX; Wei, YM; Zheng, RL1
Chun, YJ; Hong, SI; Lee, HC; Lee, SH; Lee, SJ; Park, IC; Park, MJ; Rhee, CH; Woo, SH1
Bae, JH; Choi, YJ; Kim, SP; Kwon, TK; Mun, KC; Park, JW; Song, DK; Suh, SI1
Chaudhary, PM; Matta, H; Sun, Q1
Li, J; Shen, T; Zhang, ZN; Zuo, L1
De Ridder, M; Monsaert, C; Storme, GA; Van den Berge, DL; Verovski, VN; Wauters, N1
Blasco, MA; Keefe, DL; Liu, L; Navarro, P; Trimarchi, JR1
Brannon, J; Dent, P; Fisher, PB; Gopalkrishnan, RV; Grant, S; Lebedeva, IV; Linehan, WM; McKinstry, R; Mitchell, C; Qiao, L; Rosenberg, E; Sarkar, D; Su, ZS; Valerie, K; Yacoub, A1
Aguilar, TM; Bahlis, NJ; Boise, LH; Krett, N; Lee, KP; McCafferty-Grad, J; Reis, I1
Chen, YB; Ding, SQ; Fu, WJ; Hou, J; Kong, XT; Wang, DX; Yuan, ZG1
Gao, F; Shi, GY; Tang, XM; Yi, J; Yuan, JQ1
Bae, S; Cho, CK; Chung, HY; Hong, SI; Kang, CM; Kang, YH; Kim, MJ; Lee, SJ; Lee, YS; Park, IC; Park, MJ; Park, MT; Rhee, CH; Yi, MJ1
Cao, EH; Qin, JF; Zhang, Y1
Han, ST; Kim, YH; Kwon, TK; Park, EJ; Park, JW1
Flora, SJ; Kannan, GM1
Fu, Q; Hu, BR; Li, JJ; Li, Y; Ming, ZY; Qian, JQ; Tang, Q; Xiang, JZ1
Flora, SJ; Kannan, GM; Kaul, RK; Modi, M1
Biswas, A; Chowdhury, A; Dhali, GK; Ghatak, S; Santra, A1
Flora, G; Flora, SJ; Mishra, M; Saxena, G1
Cai, J; Chen, Y; Hu, Q; Niu, X; Shi, G; Wang, J; Wu, H; Yi, J1
An, S; Choe, TB; Hong, SI; Jin, HO; Kim, ES; Kim, JI; Lee, HC; Lee, SJ; Park, IC; Rhee, CH; Seo, SK; Woo, SH; Yoo, DH1
Han, YH; Kim, SH; Kim, SZ; Park, WH1
Adachi, M; Wang, W; Zhang, R; Zhou, J; Zhu, D1
Li, B; Li, X; Sun, G; Wang, H; Wang, Y; Xu, Y; Xue, P; Zheng, Q1
Altman, JK; Dolniak, B; Glaser, H; Goussetis, DJ; Kroczynska, B; McNeer, JL; Platanias, LC; Sassano, A1
Haller, E; Mills, GB; Nanjundan, M; Patel, S; Raffoul, F; Smith, DM1
Biswas, D; Biswas, T; Sarkar, A; Sen, G1
Chen, CH; Chen, YW; Cheng, PW; Huang, CF; Hung, DZ; Liu, SH; Lu, TH; Su, CC; Wu, CC; Yang, CY1
An, Z; Huang, D; Liu, Y; Qi, Y; Zhang, W; Zhang, Y1
Chang, CF; Chen, YW; Cheng, PW; Ho, TJ; Huang, CF; Jinn, TR; Liu, SH; Lu, TH; Su, CC; Su, YC; Wu, CC; Yen, CC1
Cui, Y; Han, ZJ; Ma, X; Song, G; Xia, HF1
Chen, YA; Chiu, HW; Guo, HR; Ho, SY; Ho, YS; Wang, YJ; Wu, WJ1
Tang, X; Wang, C; Xiao, G; Yao, C1
Chen, J; Chen, L; Chen, Z; Li, J; Liao, C; Zhou, N1
Meena, R; Rani, GP; Reddy, PS; Sainath, SB; Supriya, Ch1
Emilio, R; Mahara, V; Martín, SA1
Arai, M; Hikita, E; Hirano, T; Onda, K; Tanaka, S; Toyoda, H; Utsumi, H; Yuan, B1
Park, WH; You, BR1
Murray, E; Selvaraj, V; Yeager-Armstead, M1
Boccia, P; Meconi, C; Mecozzi, M; Sturchio, E1
Chan, SM; Feng, W; Huang, M; Li, MX; Majeti, R; Mitchell, BS; Thomas, D1
Choe, TB; Choi, HN; Hong, SI; Hwang, SG; Kim, JH; Lee, HG; Lee, YH; Park, IC; Seo, SK; Yi, JY1
Bhattacharya, S; Chakraborty, A; Chattopadhyay, A; Srivastava, R1
Lai, Y; Li, Y; Luo, Q; Zhang, Z1
Anselmo-Franci, JA; Barbosa Junior, F; Borges, Cdos S; da Silva, RF; Kempinas, Wde G; Kiguti, LR; Missassi, G; Pupo, AS; Villela E Silva, P1
Li, Y; Liu, J; Ma, X; Ye, BC; Zhang, B; Zuo, P1
Afaq, F; Agarwal, A; Athar, M; Croutch, CR; Elmets, CA; Li, C; Srivastava, RK; Weng, Z1
Han, SG; Jeong, CH; Petriello, MC; Seok, JS1
Gu, B; Song, Y; Tan, X; Yang, L; Zhou, T; Zong, Y1
Baumann, J; Bendt, F; Fritsche, E; Hübenthal, U; Masjosthusmann, S; Siebert, C1
Chen, C; Deng, P; He, M; He, Z; Li, Y; Lin, M; Lu, M; Lu, Y; Ma, Q; Mou, Z; Pi, H; Yang, L; Yu, Z; Yue, Y; Zhang, H; Zhang, L; Zhang, Y; Zhou, C; Zhou, Z1

Reviews

1 review(s) available for arsenic and acetylcysteine

ArticleYear
Arsenic and lead induced free radical generation and their reversibility following chelation.
    Cellular and molecular biology (Noisy-le-Grand, France), 2007, Apr-15, Volume: 53, Issue:1

    Topics: Acetylcysteine; Adjuvants, Pharmaceutic; Animals; Antioxidants; Arsenic; Arsenic Poisoning; Ascorbic Acid; Calcium; Chelating Agents; Free Radicals; Humans; Lead; Lead Poisoning; Melatonin; Metals; Micronutrients; Molecular Structure; Succimer; Taurine; Thioctic Acid; Unithiol; Vitamin E

2007

Other Studies

55 other study(ies) available for arsenic and acetylcysteine

ArticleYear
Arsenic increased lipid peroxidation in rat tissues by a mechanism independent of glutathione levels.
    Environmental health perspectives, 1995, Volume: 103 Suppl 1

    Topics: Acetylcysteine; Animals; Arsenic; Buthionine Sulfoximine; Female; Glutamate-Cysteine Ligase; Glutathione; Lipid Peroxidation; Methionine Sulfoximine; Rats; Rats, Wistar

1995
Inhibition of tumor necrosis factor-alpha- and interleukin-1-induced endothelial E-selectin expression by thiol-modifying agents.
    Arteriosclerosis, thrombosis, and vascular biology, 1998, Volume: 18, Issue:12

    Topics: Acetylcysteine; Arsenicals; Buthionine Sulfoximine; Cells, Cultured; E-Selectin; Endothelium, Vascular; Glutathione; Glutathione Disulfide; Humans; Interleukin-1; Sulfhydryl Compounds; Tumor Necrosis Factor-alpha

1998
Malignant cells can be sensitized to undergo growth inhibition and apoptosis by arsenic trioxide through modulation of the glutathione redox system.
    Blood, 1999, Jan-01, Volume: 93, Issue:1

    Topics: Acetylcysteine; Animals; Antineoplastic Agents; Apoptosis; Arsenic Trioxide; Arsenicals; Ascorbic Acid; Cells, Cultured; Drug Synergism; Glutathione; Growth Inhibitors; Hematopoietic Stem Cells; HL-60 Cells; Humans; Lymphoma; Mice; Mice, Inbred Strains; Oxidation-Reduction; Oxides; Tumor Cells, Cultured

1999
Effects of phenylarsine oxide on expression of heme oxygenase-1 reporter constructs in transiently transfected cultures of chick embryo liver cells.
    Archives of biochemistry and biophysics, 1999, Dec-15, Volume: 372, Issue:2

    Topics: Acetylcysteine; Animals; Arsenicals; Binding, Competitive; Cells, Cultured; Chick Embryo; DNA; Dose-Response Relationship, Drug; Gene Expression Regulation, Enzymologic; Genes, Reporter; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Liver; Mutation; Nuclear Proteins; Promoter Regions, Genetic; Protein Tyrosine Phosphatases; Proto-Oncogene Proteins c-myc; Response Elements; Transcription Factor AP-1; Transfection

1999
Ascorbic acid enhances arsenic trioxide-induced cytotoxicity in multiple myeloma cells.
    Blood, 2001, Aug-01, Volume: 98, Issue:3

    Topics: Acetylcysteine; Antineoplastic Agents; Antioxidants; Arsenic Trioxide; Arsenicals; Ascorbic Acid; Cell Death; Drug Synergism; Glutathione; Humans; Hydrogen Peroxide; Multiple Myeloma; Oxides; Plasma Cells; Superoxides; Tumor Cells, Cultured

2001
Down-regulation of four arsenic antagonists on apoptosis and telomerase activity induced by arsenic trioxide in three myelocytic leukemia cell lines.
    Acta pharmacologica Sinica, 2001, Volume: 22, Issue:8

    Topics: Acetylcysteine; Aminoquinolines; Antineoplastic Agents; Apoptosis; Arsenic; Arsenic Trioxide; Arsenicals; Catalase; Down-Regulation; HL-60 Cells; Humans; K562 Cells; Leukemia, Myeloid; Oxides; Telomerase

2001
Arsenic trioxide induces apoptosis through a reactive oxygen species-dependent pathway and loss of mitochondrial membrane potential in HeLa cells.
    International journal of oncology, 2002, Volume: 21, Issue:1

    Topics: Acetylcysteine; Antineoplastic Agents; Antioxidants; Apoptosis; Arsenic Trioxide; Arsenicals; Caspases; Catalase; Dose-Response Relationship, Drug; Enzyme Activation; HeLa Cells; Humans; Hydrogen Peroxide; Membrane Potentials; Mitochondria; Oxides; Reactive Oxygen Species; Signal Transduction

2002
Arsenic trioxide-induced apoptosis in U937 cells involve generation of reactive oxygen species and inhibition of Akt.
    International journal of oncology, 2002, Volume: 21, Issue:3

    Topics: Acetylcysteine; Antineoplastic Agents; Antioxidants; Apoptosis; Arsenic Trioxide; Arsenicals; Caspase 3; Caspase Inhibitors; Caspases; Cytochrome c Group; Enzyme Activation; Humans; Oxides; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; U937 Cells

2002
The human herpes virus 8-encoded viral FLICE inhibitory protein protects against growth factor withdrawal-induced apoptosis via NF-kappa B activation.
    Blood, 2003, Mar-01, Volume: 101, Issue:5

    Topics: Acetylcysteine; Acute Disease; Apoptosis; Arsenic Trioxide; Arsenicals; bcl-X Protein; Cell Transformation, Viral; Enzyme Activation; Gene Expression Regulation, Viral; Granulocyte-Macrophage Colony-Stimulating Factor; Herpesvirus 8, Human; Humans; I-kappa B Proteins; Leukemia, Myeloid; Leupeptins; Mitochondria; Myeloid Cell Leukemia Sequence 1 Protein; Neoplasm Proteins; NF-kappa B; Oxides; Proto-Oncogene Proteins c-bcl-2; Recombinant Fusion Proteins; Recombinant Proteins; Rhadinovirus; Transcription, Genetic; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha; Viral Proteins

2003
[The comparison between the mechanisms of sodium selenite induced apoptosis and arsenic trioxide induced apoptosis in human acute promyelocytic leukemia cell line NB4 cells].
    Zhongguo shi yan xue ye xue za zhi, 2002, Volume: 10, Issue:3

    Topics: Acetylcysteine; Apoptosis; Arsenic Trioxide; Arsenicals; Cell Division; DNA, Neoplasm; Flow Cytometry; Glutathione; Humans; Intracellular Membranes; Leukemia, Promyelocytic, Acute; Membrane Potentials; Mitochondria; Oxides; Reactive Oxygen Species; Sodium Selenite; Tumor Cells, Cultured

2002
NF-kappaB inhibition impairs the radioresponse of hypoxic EMT-6 tumour cells through downregulation of inducible nitric oxide synthase.
    British journal of cancer, 2003, Jan-13, Volume: 88, Issue:1

    Topics: Acetylcysteine; Animals; Anti-Bacterial Agents; Arsenicals; Cell Hypoxia; Cysteine Endopeptidases; Down-Regulation; Lactams; Mice; Multienzyme Complexes; NF-kappa B; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oxygen; Proteasome Endopeptidase Complex; Radiation Tolerance; Tumor Cells, Cultured

2003
Oxidative stress contributes to arsenic-induced telomere attrition, chromosome instability, and apoptosis.
    The Journal of biological chemistry, 2003, Aug-22, Volume: 278, Issue:34

    Topics: Acetylcysteine; Animals; Antioxidants; Apoptosis; Arsenic; Embryonic and Fetal Development; Female; Mice; Mice, Knockout; Oxidative Stress; Telomere

2003
MDA-7 (interleukin-24) inhibits the proliferation of renal carcinoma cells and interacts with free radicals to promote cell death and loss of reproductive capacity.
    Molecular cancer therapeutics, 2003, Volume: 2, Issue:7

    Topics: Acetylcysteine; Adenoviridae; Adjuvants, Immunologic; Apoptosis; Arsenic Trioxide; Arsenicals; bcl-X Protein; Brain Neoplasms; Carcinoma, Renal Cell; Caspases; Cell Division; Free Radical Scavengers; Free Radicals; Genes, Tumor Suppressor; Glioma; Glutathione Transferase; Humans; Interleukins; Kidney; Kidney Neoplasms; Oxides; Poly(ADP-ribose) Polymerases; Proto-Oncogene Proteins c-bcl-2; Receptors, Virus; Recombinant Fusion Proteins; Tumor Cells, Cultured

2003
Arsenic trioxide uses caspase-dependent and caspase-independent death pathways in myeloma cells.
    Molecular cancer therapeutics, 2003, Volume: 2, Issue:11

    Topics: Acetylcysteine; Apoptosis; Arsenic Trioxide; Arsenicals; Caspase Inhibitors; Caspases; Drug Resistance, Neoplasm; Humans; Leukemia, Promyelocytic, Acute; Oxides; Plasma Cells; Superoxides; Tumor Cells, Cultured

2003
[Mechanism of arsenic trioxide-induced cytotoxicity on multiple myeloma cells].
    Ai zheng = Aizheng = Chinese journal of cancer, 2003, Volume: 22, Issue:12

    Topics: Acetylcysteine; Antineoplastic Agents; Arsenic Trioxide; Arsenicals; Cell Division; Cell Survival; Drug Interactions; Glutathione; Humans; Multiple Myeloma; Oxides; Tumor Cells, Cultured; Vitamin K 3

2003
The cell cycle related apoptotic susceptibility to arsenic trioxide is associated with the level of reactive oxygen species.
    Cell research, 2004, Volume: 14, Issue:1

    Topics: Acetylcysteine; Antineoplastic Agents; Apoptosis; Arsenic Trioxide; Arsenicals; Catalase; Cell Cycle; Cell Division; Cell Line, Tumor; Dactinomycin; Flow Cytometry; Fluoresceins; Humans; In Situ Nick-End Labeling; Interphase; Naphthoquinones; Oxides; Propidium; Reactive Oxygen Species

2004
Caspase-independent cell death by arsenic trioxide in human cervical cancer cells: reactive oxygen species-mediated poly(ADP-ribose) polymerase-1 activation signals apoptosis-inducing factor release from mitochondria.
    Cancer research, 2004, Dec-15, Volume: 64, Issue:24

    Topics: Acetylcysteine; Apoptosis; Apoptosis Inducing Factor; Arsenicals; Caspases; Cell Line, Tumor; Cell Nucleus; Chlorides; Enzyme Activation; Female; Flavoproteins; Humans; Intracellular Membranes; Membrane Potentials; Membrane Proteins; Mitochondria; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Reactive Oxygen Species; RNA, Small Interfering; Signal Transduction; Uterine Cervical Neoplasms

2004
Up-regulation of telomere-binding TRF1, TRF2 related to reactive oxygen species induced by As(2)O(3) in MGC-803 cells.
    European journal of pharmacology, 2005, May-23, Volume: 516, Issue:1

    Topics: 8-Hydroxy-2'-Deoxyguanosine; Acetylcysteine; Antineoplastic Agents; Apoptosis; Arsenic Trioxide; Arsenicals; Blotting, Western; Cell Cycle; Cell Division; Cell Line, Tumor; Deoxyguanosine; Flow Cytometry; G2 Phase; Gene Expression Regulation, Neoplastic; Humans; Microscopy, Atomic Force; Oxides; Protein Binding; Reactive Oxygen Species; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Telomere; Telomeric Repeat Binding Protein 1; Telomeric Repeat Binding Protein 2; Tumor Suppressor Protein p53; Up-Regulation

2005
Arsenic trioxide induces Hsp70 expression via reactive oxygen species and JNK pathway in MDA231 cells.
    Life sciences, 2005, Oct-14, Volume: 77, Issue:22

    Topics: Acetylcysteine; Anthracenes; Arsenic Trioxide; Arsenicals; Blotting, Western; Cells, Cultured; DNA Primers; DNA-Binding Proteins; Gene Expression Regulation; Heat Shock Transcription Factors; HSP70 Heat-Shock Proteins; Humans; Luciferases; MAP Kinase Kinase 4; Oxides; Reactive Oxygen Species; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Transcription Factors

2005
Combined administration of N-acetylcysteine and monoisoamyl DMSA on tissue oxidative stress during arsenic chelation therapy.
    Biological trace element research, 2006, Volume: 110, Issue:1

    Topics: Acetylcysteine; Animals; Arsenic; Chelation Therapy; Guinea Pigs; Male; Oxidative Stress; Succimer

2006
Role of oxidative stress in the apoptosis of hepatocellular carcinoma induced by combination of arsenic trioxide and ascorbic acid.
    Acta pharmacologica Sinica, 2006, Volume: 27, Issue:8

    Topics: Acetylcysteine; Antineoplastic Agents; Antioxidants; Apoptosis; Arsenic Trioxide; Arsenicals; Ascorbic Acid; bcl-2-Associated X Protein; Carcinoma, Hepatocellular; Cell Line, Tumor; Drug Synergism; Free Radical Scavengers; Humans; Liver Neoplasms; Oxidative Stress; Oxides; Proto-Oncogene Proteins c-bcl-2

2006
Co-administration of zinc and n-acetylcysteine prevents arsenic-induced tissue oxidative stress in male rats.
    Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS), 2006, Volume: 20, Issue:3

    Topics: Acetylcysteine; Administration, Oral; Alanine Transaminase; Animals; Arsenic; Arsenites; Aspartate Aminotransferases; Drug Synergism; Kidney; Liver; Male; Oxidative Stress; Porphobilinogen Synthase; Rats; Rats, Wistar; Sodium Compounds; Tissue Distribution; Zinc

2006
Arsenic induces apoptosis in mouse liver is mitochondria dependent and is abrogated by N-acetylcysteine.
    Toxicology and applied pharmacology, 2007, Apr-15, Volume: 220, Issue:2

    Topics: Acetylcysteine; Alanine Transaminase; Animals; Apoptosis; Arsenic; Chemical and Drug Induced Liver Injury; Free Radical Scavengers; Glutathione; Hepatocytes; In Situ Nick-End Labeling; Liver; Liver Function Tests; Male; Mice; Mice, Inbred BALB C; Mitochondria, Liver; Oxidative Stress; Poly(ADP-ribose) Polymerases; Triglycerides

2007
Emodin-induced generation of reactive oxygen species inhibits RhoA activation to sensitize gastric carcinoma cells to anoikis.
    Neoplasia (New York, N.Y.), 2008, Volume: 10, Issue:1

    Topics: Acetylcysteine; Actins; Anoikis; Arsenic Trioxide; Arsenicals; Carcinoma; Cell Line, Tumor; Emodin; Free Radical Scavengers; Humans; Oxidative Stress; Oxides; Protein Kinase Inhibitors; Reactive Oxygen Species; rhoA GTP-Binding Protein; Stomach Neoplasms; Transfection

2008
A combination of sulindac and arsenic trioxide synergistically induces apoptosis in human lung cancer H1299 cells via c-Jun NH2-terminal kinase-dependent Bcl-xL phosphorylation.
    Lung cancer (Amsterdam, Netherlands), 2008, Volume: 61, Issue:3

    Topics: Acetylcysteine; Apoptosis; Arsenic Trioxide; Arsenicals; bcl-X Protein; Carcinoma, Non-Small-Cell Lung; Caspases; Cell Line, Tumor; Drug Synergism; Humans; JNK Mitogen-Activated Protein Kinases; Lung Neoplasms; Membrane Potential, Mitochondrial; Mitochondria; Oxides; Phosphorylation; Reactive Oxygen Species; Signal Transduction; Sulindac

2008
Suppression of arsenic trioxide-induced apoptosis in HeLa cells by N-acetylcysteine.
    Molecules and cells, 2008, Jul-31, Volume: 26, Issue:1

    Topics: Acetylcysteine; Antineoplastic Agents; Apoptosis; Arsenic Trioxide; Arsenicals; Catalase; Cell Cycle; Free Radical Scavengers; Glutathione; Growth Inhibitors; HeLa Cells; Humans; Membrane Potential, Mitochondrial; Oxides; Reactive Oxygen Species; Superoxide Dismutase; Superoxides

2008
A novel combination therapy with arsenic trioxide and parthenolide against pancreatic cancer cells.
    Pancreas, 2009, Volume: 38, Issue:4

    Topics: Acetylcysteine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Arsenic Trioxide; Arsenicals; Blotting, Western; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Drug Synergism; Flow Cytometry; Growth Inhibitors; Humans; In Situ Nick-End Labeling; Membrane Potential, Mitochondrial; Mice; Mice, Nude; Oxides; Pancreatic Neoplasms; Reactive Oxygen Species; Sesquiterpenes; Xenograft Model Antitumor Assays

2009
Arsenic induces mitochondria-dependent apoptosis by reactive oxygen species generation rather than glutathione depletion in Chang human hepatocytes.
    Archives of toxicology, 2009, Volume: 83, Issue:10

    Topics: Acetylcysteine; Apoptosis; Arsenic; Arsenites; Cell Survival; Cells, Cultured; Cytochromes c; Glutathione; Hepatocytes; Humans; Malondialdehyde; Membrane Potential, Mitochondrial; Mitochondria; Reactive Oxygen Species; Sodium Compounds

2009
Arsenic trioxide-dependent activation of thousand-and-one amino acid kinase 2 and transforming growth factor-beta-activated kinase 1.
    Molecular pharmacology, 2010, Volume: 77, Issue:5

    Topics: Acetylcysteine; Arsenic Trioxide; Arsenicals; Cell Line, Tumor; Dithiothreitol; Enzyme Activation; Genetic Variation; Hematopoietic Stem Cells; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; MAP Kinase Kinase Kinases; Oxides; Phosphorylation; Protein Kinases; Reactive Oxygen Species; RNA, Small Interfering; Tretinoin; U937 Cells

2010
Arsenic trioxide induces a beclin-1-independent autophagic pathway via modulation of SnoN/SkiL expression in ovarian carcinoma cells.
    Cell death and differentiation, 2010, Volume: 17, Issue:12

    Topics: Acetylcysteine; Apoptosis Regulatory Proteins; Arsenic Trioxide; Arsenicals; Autophagy; Autophagy-Related Protein 5; Autophagy-Related Protein 7; Beclin-1; Carcinoma; Cell Line, Tumor; Female; Humans; Intracellular Signaling Peptides and Proteins; Membrane Proteins; Microtubule-Associated Proteins; Multidrug Resistance-Associated Proteins; Ovarian Neoplasms; Oxides; Poly(ADP-ribose) Polymerases; Proto-Oncogene Proteins; Reactive Oxygen Species; RNA Interference; RNA, Small Interfering; Signal Transduction; Transforming Growth Factor beta; Ubiquitin-Activating Enzymes

2010
Atorvastatin acts synergistically with N-acetyl cysteine to provide therapeutic advantage against Fas-activated erythrocyte apoptosis during chronic arsenic exposure in rats.
    Toxicology and applied pharmacology, 2011, Jan-01, Volume: 250, Issue:1

    Topics: Acetylcysteine; Animals; Anticholesteremic Agents; Apoptosis; Arsenic; Arsenic Poisoning; Atorvastatin; Cell Membrane; Drug Synergism; Environmental Pollutants; Erythrocytes; fas Receptor; Free Radical Scavengers; Glutathione; Heptanoic Acids; Male; Oxidative Stress; Pyrroles; Rats; Rats, Sprague-Dawley; Signal Transduction

2011
Arsenic induces pancreatic β-cell apoptosis via the oxidative stress-regulated mitochondria-dependent and endoplasmic reticulum stress-triggered signaling pathways.
    Toxicology letters, 2011, Feb-25, Volume: 201, Issue:1

    Topics: Acetylcysteine; Animals; Apoptosis; Arsenic; Cell Line, Tumor; Cell Survival; Endoplasmic Reticulum; Endoplasmic Reticulum Chaperone BiP; Insulin; Insulin Secretion; Insulin-Secreting Cells; Lipid Peroxidation; Male; Mice; Mice, Inbred ICR; Mitochondria; Mitogen-Activated Protein Kinases; Oxidative Stress; Phosphorylation; Poly(ADP-ribose) Polymerases; Rats; Reactive Oxygen Species; Signal Transduction; Tumor Suppressor Protein p53

2011
Mediating effect of ROS on mtDNA damage and low ATP content induced by arsenic trioxide in mouse oocytes.
    Toxicology in vitro : an international journal published in association with BIBRA, 2011, Volume: 25, Issue:4

    Topics: Acetylcysteine; Adenosine Triphosphate; Animals; Arsenic Trioxide; Arsenicals; DNA Damage; DNA, Mitochondrial; Female; Mice; Mitochondria; Oocytes; Oxidative Stress; Oxides; Reactive Oxygen Species

2011
Inorganic arsenic causes cell apoptosis in mouse cerebrum through an oxidative stress-regulated signaling pathway.
    Archives of toxicology, 2011, Volume: 85, Issue:6

    Topics: Acetylcysteine; Animals; Apoptosis; Apoptosis Regulatory Proteins; Arsenic Poisoning; Arsenic Trioxide; Arsenicals; Cerebral Cortex; Dose-Response Relationship, Drug; Endoplasmic Reticulum Chaperone BiP; Environmental Pollutants; Gene Expression Regulation, Enzymologic; Glutathione; Glutathione Peroxidase; Lipid Peroxides; Male; MAP Kinase Signaling System; Mice; Mice, Inbred ICR; NAD(P)H Dehydrogenase (Quinone); Nerve Tissue Proteins; Neurons; Neuroprotective Agents; Oxidation-Reduction; Oxidative Stress; Oxides; Random Allocation; RNA, Messenger

2011
Oxidative stress is implicated in arsenic-induced neural tube defects in chick embryos.
    International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 2011, Volume: 29, Issue:7

    Topics: Acetylcysteine; Animals; Arsenic; Chick Embryo; Epigenesis, Genetic; Female; Glutathione Peroxidase; Malondialdehyde; Neural Tube Defects; Oxidative Stress; Reactive Oxygen Species; S-Adenosylhomocysteine; S-Adenosylmethionine; Superoxide Dismutase

2011
Arsenic trioxide and radiation enhance apoptotic effects in HL-60 cells through increased ROS generation and regulation of JNK and p38 MAPK signaling pathways.
    Chemico-biological interactions, 2011, Sep-05, Volume: 193, Issue:2

    Topics: Acetylcysteine; Antineoplastic Agents; Apoptosis; Arsenic Trioxide; Arsenicals; bcl-2-Associated X Protein; Caspase 3; Cell Cycle; Cell Cycle Proteins; Cell Survival; Cyclins; DNA Fragmentation; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; F-Box Proteins; F-Box-WD Repeat-Containing Protein 7; HL-60 Cells; Humans; JNK Mitogen-Activated Protein Kinases; Membrane Potential, Mitochondrial; Models, Biological; Oxides; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Poly(ADP-ribose) Polymerases; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; Signal Transduction; Tumor Stem Cell Assay; Ubiquitin-Protein Ligases; X-Rays

2011
Potentiation of arsenic trioxide-induced apoptosis by 8-bromo-7-methoxychrysin in human leukemia cells involves depletion of intracellular reduced glutathione.
    Acta biochimica et biophysica Sinica, 2011, Volume: 43, Issue:9

    Topics: Acetylcysteine; Antineoplastic Agents; Apoptosis; Arsenic Trioxide; Arsenicals; bcl-2-Associated X Protein; bcl-X Protein; Blotting, Western; Cell Survival; Cytochromes c; Dose-Response Relationship, Drug; Drug Synergism; Flavonoids; Glutathione; HL-60 Cells; Humans; Intracellular Space; Jurkat Cells; Leukemia; Mitochondria; Oxides; Phosphorylation; Proto-Oncogene Proteins c-akt; Time Factors; U937 Cells; X-Linked Inhibitor of Apoptosis Protein

2011
Synergy of glutathione, dithiothreitol and N-acetyl-L-cysteine self-assembled monolayers for electrochemical assay: sensitive determination of arsenic(III) in environmental and drinking water.
    The Analyst, 2011, Nov-07, Volume: 136, Issue:21

    Topics: Acetylcysteine; Arsenic; Dithiothreitol; Drinking Water; Electrochemical Techniques; Electrodes; Glutathione; Gold; Limit of Detection; Seawater; Water Pollutants, Chemical

2011
Protective effects of N-acetylcysteine against arsenic-induced oxidative stress and reprotoxicity in male mice.
    Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS), 2011, Volume: 25, Issue:4

    Topics: 17-Hydroxysteroid Dehydrogenases; Acetylcysteine; Animals; Antioxidants; Arsenic; Body Weight; Epididymis; Lipid Peroxidation; Male; Mice; Oxidative Stress; Protective Agents; Reproduction; Spermatozoa; Testis; Testosterone

2011
Role of oxidative stress in transformation induced by metal mixture.
    Oxidative medicine and cellular longevity, 2011, Volume: 2011

    Topics: Acetylcysteine; Air Pollutants; Animals; Arsenic; BALB 3T3 Cells; Cadmium; Carcinogens, Environmental; Cell Survival; Cell Transformation, Neoplastic; Free Radical Scavengers; Humans; Lead; Mice; Oxidative Stress; Reactive Oxygen Species

2011
Effects of inorganic and organic arsenic compounds on growth and apoptosis of human T-lymphoblastoid leukemia cells.
    Anticancer research, 2011, Volume: 31, Issue:12

    Topics: Acetylcysteine; Apoptosis; Arsenic; Ascorbic Acid; Benzimidazoles; Buthionine Sulfoximine; Caspase 3; Caspase 7; Cell Line, Tumor; Cell Proliferation; Female; Humans; Inhibitory Concentration 50; Leukemia, T-Cell; Leukocytes, Mononuclear; Models, Chemical; Organic Chemicals; T-Lymphocytes; Tetrazolium Salts; Thiazoles

2011
Arsenic trioxide induces human pulmonary fibroblast cell death via increasing ROS levels and GSH depletion.
    Oncology reports, 2012, Volume: 28, Issue:2

    Topics: Acetylcysteine; Antineoplastic Agents; Antioxidants; Apoptosis; Arsenic Trioxide; Arsenicals; Ascorbic Acid; Buthionine Sulfoximine; Cell Death; Cell Line, Tumor; Fibroblasts; Glutathione; Humans; Lung; Oxides; Reactive Oxygen Species; Transfection

2012
Protective and antioxidant role of selenium on arsenic trioxide-induced oxidative stress and genotoxicity in the fish hepatoma cell line PLHC-1.
    Environmental toxicology and chemistry, 2012, Volume: 31, Issue:12

    Topics: Acetylcysteine; Animals; Antioxidants; Apoptosis; Arsenic Trioxide; Arsenicals; Caspase 3; Cell Line, Tumor; DNA Damage; Fishes; Free Radical Scavengers; Hazardous Substances; Membrane Potential, Mitochondrial; Mutagens; Oxidative Stress; Oxides; Reactive Oxygen Species; Selenium

2012
Molecular modifications induced by inorganic arsenic in Vicia faba investigated by FTIR, FTNIR spectroscopy and genotoxicity testing.
    Journal of toxicology and environmental health. Part A, 2013, Volume: 76, Issue:4-5

    Topics: Acetylcysteine; Antioxidants; Arsenic; Comet Assay; Micronucleus Tests; Plant Roots; Seedlings; Spectroscopy, Fourier Transform Infrared; Vicia faba

2013
Role of cysteine 288 in nucleophosmin cytoplasmic mutations: sensitization to toxicity induced by arsenic trioxide and bortezomib.
    Leukemia, 2013, Volume: 27, Issue:10

    Topics: Acetylcysteine; Antineoplastic Agents; Apoptosis; Arsenic Trioxide; Arsenicals; Boronic Acids; Bortezomib; Cell Nucleolus; Cell Proliferation; Cysteine; Cytosol; Drug Resistance, Neoplasm; Flow Cytometry; Free Radical Scavengers; Humans; Leukemia, Myeloid, Acute; Mutation; Nuclear Proteins; Nucleophosmin; Oxides; Pyrazines; Reactive Oxygen Species; Tryptophan; Tumor Cells, Cultured

2013
Knockdown of TWIST1 enhances arsenic trioxide- and ionizing radiation-induced cell death in lung cancer cells by promoting mitochondrial dysfunction.
    Biochemical and biophysical research communications, 2014, Jul-11, Volume: 449, Issue:4

    Topics: Acetylcysteine; Arsenic Trioxide; Arsenicals; Carcinoma, Non-Small-Cell Lung; Cell Death; Gene Knockdown Techniques; Humans; Membrane Potential, Mitochondrial; Nuclear Proteins; Oxides; Radiation, Ionizing; Reactive Oxygen Species; RNA, Small Interfering; Twist-Related Protein 1

2014
Differential in vivo genotoxicity of arsenic trioxide in glutathione depleted mouse bone marrow cells: expressions of Nrf2/Keap1/P62.
    Toxicology mechanisms and methods, 2015, Volume: 25, Issue:3

    Topics: Acetylcysteine; Adaptor Proteins, Signal Transducing; Animals; Arsenic Trioxide; Arsenicals; Bone Marrow Cells; Buthionine Sulfoximine; Chromatids; Chromosome Aberrations; Cytoskeletal Proteins; Dose-Response Relationship, Drug; Enzyme Inhibitors; Free Radical Scavengers; Gene Expression Regulation, Neoplastic; Glutamate-Cysteine Ligase; Glutathione; Kelch-Like ECH-Associated Protein 1; Male; Membrane Glycoproteins; Mice; Mutagens; Neoplasm Proteins; NF-E2-Related Factor 2; Nuclear Pore Complex Proteins; Oxides

2015
The role of NF-κB in PARP-inhibitor-mediated sensitization and detoxification of arsenic trioxide in hepatocellular carcinoma cells.
    The Journal of toxicological sciences, 2015, Volume: 40, Issue:3

    Topics: 1-Naphthylamine; Acetylcysteine; Antineoplastic Agents; Antioxidants; Arsenic Trioxide; Arsenicals; Carcinoma, Hepatocellular; DNA Damage; Hep G2 Cells; Humans; Inactivation, Metabolic; Liver Neoplasms; Naphthalimides; NF-kappa B; Oxidative Stress; Oxides; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Quinolones; Reactive Oxygen Species

2015
The Coadministration of N-Acetylcysteine Ameliorates the Effects of Arsenic Trioxide on the Male Mouse Genital System.
    Oxidative medicine and cellular longevity, 2016, Volume: 2016

    Topics: Acetylcysteine; Animals; Arsenic; Arsenic Trioxide; Arsenicals; Body Weight; Epididymis; Male; Mice; Organ Size; Oxides; Random Allocation; Reactive Oxygen Species; Sperm Motility; Spermatogenesis; Spermatozoa; Testis; Testosterone

2016
Ultrasensitive and selective assay of glutathione species in arsenic trioxide-treated leukemia HL-60 cell line by molecularly imprinted polymer decorated electrochemical sensors.
    Biosensors & bioelectronics, 2016, Jun-15, Volume: 80

    Topics: Acetylcysteine; Arsenic Trioxide; Arsenicals; Biosensing Techniques; Dielectric Spectroscopy; Glutathione; Glutathione Disulfide; HL-60 Cells; Humans; Leukemia; Molecular Imprinting; Oxides; Polymers

2016
Molecular Mechanism Underlying Pathogenesis of Lewisite-Induced Cutaneous Blistering and Inflammation: Chemical Chaperones as Potential Novel Antidotes.
    The American journal of pathology, 2016, Volume: 186, Issue:10

    Topics: Acetylcysteine; Animals; Antidotes; Antioxidants; Arsenicals; Blister; Chemical Warfare Agents; Disease Models, Animal; Female; Humans; Inflammation; Keratinocytes; Male; Mice; Mice, Hairless; Mice, Inbred C57BL; Molecular Chaperones; Patched-1 Receptor; Phenylbutyrates; Reactive Oxygen Species; Signal Transduction

2016
Arsenic downregulates tight junction claudin proteins through p38 and NF-κB in intestinal epithelial cell line, HT-29.
    Toxicology, 2017, 03-15, Volume: 379

    Topics: Acetylcysteine; Arsenic; Claudins; Down-Regulation; Glutathione; HT29 Cells; Humans; Intestinal Mucosa; NF-kappa B; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Tight Junctions

2017
Arsenic inhibited cholesterol efflux of THP-1 macrophages via ROS-mediated ABCA1 hypermethylation.
    Toxicology, 2019, 08-01, Volume: 424

    Topics: Acetylcysteine; Antioxidants; Arsenic; ATP Binding Cassette Transporter 1; Cell Line; Cholesterol; DNA (Cytosine-5-)-Methyltransferase 1; DNA Methylation; Humans; Macrophages; Methylation; Oxidative Stress; Reactive Oxygen Species; S-Adenosylmethionine

2019
Arsenite interrupts neurodevelopmental processes of human and rat neural progenitor cells: The role of reactive oxygen species and species-specific antioxidative defense.
    Chemosphere, 2019, Volume: 235

    Topics: Acetylcysteine; Animals; Antioxidants; Arsenic; Arsenites; Glutathione; Hazardous Substances; Heme Oxygenase-1; Humans; Neurogenesis; Neurons; Oxidative Stress; Rats; Reactive Oxygen Species; Sodium Compounds; Species Specificity; Stem Cells; Toxicity Tests

2019
NAC antagonizes arsenic-induced neurotoxicity through TMEM179 by inhibiting oxidative stress in Oli-neu cells.
    Ecotoxicology and environmental safety, 2021, Oct-15, Volume: 223

    Topics: Acetylcysteine; Animals; Apoptosis; Arsenic; Mice; Mitochondria; Oxidative Stress; Reactive Oxygen Species

2021