Dourine

A disease of horses and donkeys caused by Trypanosoma equiperdum. The disease occurs in Africa, the Americas, and Asia.

Synonym
Dourine

Excerpt	Reference
"Dourine is a lethal protozoan disease of equids, and it is caused by Trypanosoma equiperdum infection via coitus."	( Battsetseg, B; Battur, B; Davaasuren, B; Davkharbayar, B; Inoue, N; Mizushima, D; Narantsatsral, S; Punsantsogvoo, M; Suganuma, K, 2020)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	2 (28.57)	23.3326
1990's	1 (14.29)	12.5806
2000's	0 (0.00)	18.1394
2010's	3 (42.86)	28.8240
2020's	1 (14.29)	9.53

Drug	Relationship Strength	Studies
diminazene	low	1
pentamidine	low	2
pentane	low	1
quinapyramine	low	1
melarsomine dihydrochloride	low	1
diminazene aceturate	low	1
antimony	low	1
arsenic	low	1
agar	low	1

Protein Targets (72)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Cathepsin B	0	1	0	1
Furin	0	1	0	1
Amiloride-sensitive amine oxidase [copper-containing]	0	2	0	2
Diamine acetyltransferase 1	0	2	0	2
Acid-sensing ion channel 1	0	1	0	1
Acid-sensing ion channel 2	0	1	0	1
PPM1D protein	1	0	0	1
EWS/FLI fusion protein	1	0	0	1
Protein arginine N-methyltransferase 5	0	1	0	1
Solute carrier family 22 member 2	0	1	0	1
Solute carrier family 22 member 1	0	1	0	1
ATP-binding cassette sub-family C member 3	0	1	0	1
Multidrug resistance-associated protein 4	0	1	0	1
5-hydroxytryptamine receptor 4	0	2	0	2
Protein tyrosine phosphatase type IVA 3	0	1	0	1
Solute carrier family 22 member 3	0	1	0	1
Bile salt export pump	0	1	0	1
Coagulation factor X	0	1	0	1
Plasminogen	0	1	0	1
Urokinase-type plasminogen activator	0	1	0	1
Interferon beta	1	0	0	1
Protein S100-B	0	1	1	2
Glyceraldehyde-3-phosphate dehydrogenase	0	1	0	1
Protein S100-B	0	0	1	1
Cytochrome P450 1A2	0	1	0	1
Trypsin-1	0	1	0	1
Aldo-keto reductase family 1 member B1	0	2	0	2
Acrosin	0	1	0	1
Muscarinic acetylcholine receptor M2	0	2	0	2
Muscarinic acetylcholine receptor M4	0	2	0	2
Cytochrome P450 3A4	0	1	0	1
Muscarinic acetylcholine receptor M5	0	2	0	2
Alpha-2A adrenergic receptor	0	2	0	2
Cytochrome P450 2D6	0	1	0	1
60 kDa heat shock protein, mitochondrial	0	1	0	1
Cytochrome P450 2C9	0	1	0	1
Angiotensin-converting enzyme	0	2	0	2
Amine oxidase [flavin-containing] A	0	1	0	1
Sodium-dependent noradrenaline transporter	0	2	0	2
5-hydroxytryptamine receptor 2A	0	2	0	2
5-hydroxytryptamine receptor 2C	0	2	0	2
Cytochrome P450 2C19	0	1	0	1
D(3) dopamine receptor	0	2	0	2
10 kDa heat shock protein, mitochondrial	0	1	0	1
Sodium-dependent dopamine transporter	0	2	0	2
Glutamate receptor ionotropic, NMDA 1	0	1	0	1
Potassium voltage-gated channel subfamily H member 2	0	2	0	2
Glutamate receptor ionotropic, NMDA 2A	0	1	0	1
Protein tyrosine phosphatase type IVA 2	0	1	0	1
60 kDa chaperonin	0	1	0	1
Nuclear receptor subfamily 3 group C member 3	0	2	0	2
10 kDa chaperonin	0	1	0	1
Multidrug and toxin extrusion protein 2	0	1	0	1
Canalicular multispecific organic anion transporter 1	0	1	0	1
Protein tyrosine phosphatase type IVA 1	0	1	0	1
Multidrug and toxin extrusion protein 1	0	1	0	1
Aurora kinase B	0	1	0	1
Protein arginine N-methyltransferase 1	0	1	0	1
Suppressor of tumorigenicity 14 protein	0	1	0	1
GLI family zinc finger 3	1	0	0	1
thyroid stimulating hormone receptor	1	0	0	1
estrogen-related nuclear receptor alpha	1	0	0	1
pregnane X nuclear receptor	1	0	0	1
aryl hydrocarbon receptor	1	0	0	1
thyrotropin-releasing hormone receptor	1	0	0	1
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	1	0	0	1
histone deacetylase 9 isoform 3	1	0	0	1
nuclear factor erythroid 2-related factor 2 isoform 1	1	0	0	1
peripheral myelin protein 22	1	0	0	1
lamin isoform A-delta10	1	0	0	1
15-lipoxygenase, partial	1	0	0	1
nonstructural protein 1	1	0	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(1)

Research Excerpts

Overview

Research

Studies (7)

Protein Targets (72)

Dourine

Synonyms(1)

Research Excerpts

Overview

Research

Studies (7)

Drugs Studied (10)

Protein Targets (72)