trimethylarsine

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

trimethylarsine : An arsine that is arsane in which each of the hydrogens is substituted by a methyl group. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID Source	ID
PubMed CID	68978
CHEBI ID	27130
MeSH ID	M0054399

Synonyms (18)

Synonym
593-88-4
CHEBI:27130
(ch3)3as
trimethylarsane
asme3
einecs 209-815-8
brn 1730780
arsine, trimethyl-
trimethylarsenic
trimethylarsine
mq83uq8a1q ,
unii-mq83uq8a1q
4-04-00-03665 (beilstein handbook reference)
DTXSID4073203
mfcd00014838
trimethylarsine, elec. gr.
FT-0767762
Q421500

Research Excerpts

Toxicity

Excerpt	Reference	Relevance
"Trimethylarsine (TM-As) proved to be an arsenic compound of low toxicity, with a po LD50 of 7870 mg/kg in mice."	( Toxicity and metabolism of trimethylarsine in mice and hamsters. Kaise, T; Takahashi, K; Yamamura, Y; Yamauchi, H, 1990)	2.02

Compound-Compound Interactions

Excerpt	Reference	Relevance
"The simultaneous detection of arsenic and sulfur in thioarsenicals was achieved using xenon-based collision-cell inductively coupled plasma (ICP) mass spectrometry (MS) in combination with high-performance liquid chromatography."	( Complementary molecular and elemental detection of speciated thioarsenicals using ESI-MS in combination with a xenon-based collision-cell ICP-MS with application to fortified NIST freeze-dried urine. Caruso, JA; Conklin, SD; Creed, JT; Creed, PA; Ellis, JL; Gallawa, CM; Kubachka, KM; Young, AR, 2008)	0.35

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

Class	Description
arsine	Arsane (AsH3) and compounds derived from it by substituting one, two or three hydrogen atoms by hydrocarbyl groups: RAsH2, R2AsH, R3As (R =/= H) are called primary, secondary and tertiary arsines, respectively. A specific arsine is preferably named as a substituted arsane.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Research

Studies (22)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	7 (31.82)	18.7374
1990's	2 (9.09)	18.2507
2000's	11 (50.00)	29.6817
2010's	2 (9.09)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 30.89

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	30.89 (24.57)
Research Supply Index	3.14 (2.92)
Research Growth Index	4.87 (4.65)
Search Engine Demand Index	33.89 (26.88)
Search Engine Supply Index	2.00 (0.95)

This Compound (30.89)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	1 (4.55%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	21 (95.45%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
arsenic acid arsenic acid: RN given refers to orthoarsenic acid(H3AsO4); see also sodium arsenate. arsenic acid : An arsenic oxoacid comprising one oxo group and three hydroxy groups attached to a central arsenic atom.	3.56	2	arsenic oxoacid	Escherichia coli metabolite
cacodylic acid dimethylarsinic acid : The organoarsenic compound that is arsenic acid substituted on the central arsenic atom with two methyl groups.	3.11	5	organoarsenic compound	xenobiotic metabolite
cycloheximide Cycloheximide: Antibiotic substance isolated from streptomycin-producing strains of Streptomyces griseus. It acts by inhibiting elongation during protein synthesis.. cycloheximide : A dicarboximide that is 4-(2-hydroxyethyl)piperidine-2,6-dione in which one of the hydrogens attached to the carbon bearing the hydroxy group is replaced by a 3,5-dimethyl-2-oxocyclohexyl group. It is an antibiotic produced by the bacterium Streptomyces griseus.	1.96	1	antibiotic fungicide; cyclic ketone; dicarboximide; piperidine antibiotic; piperidones; secondary alcohol	anticoronaviral agent; bacterial metabolite; ferroptosis inhibitor; neuroprotective agent; protein synthesis inhibitor
monomethylarsonic acid monomethylarsonic acid: structure given in first source	1.96	1	arsonic acids; one-carbon compound; organoarsonic acid
arsenamide Arsenamide: Proposed chemotherapeutic agent against filaria and trichomonas.	2.04	1
xenon Xenon: A noble gas with the atomic symbol Xe, atomic number 54, and atomic weight 131.30. It is found in the earth's atmosphere and has been used as an anesthetic.	2.04	1	monoatomic xenon; noble gas atom; p-block element atom
arsenobetaine [no description available]	1.97	1	organic salt
arsenocholine arsenocholine : An arsonium ion that is choline in which the central nitrogen has been replaced by arsenic.	1.97	1	arsonium ion; organoarsenic compound	human urinary metabolite; marine metabolite; xenobiotic
trimethylarsine oxide trimethylarsine oxide: sodium arsenate metabolite in fish	7.69	3	arsine oxides
dimethylarsinous acid dimethylarsinous acid: a reactive organic intermediate of dimethylarsinic acid involved in toxicity	2.01	1	methylarsinous acid
dimethylarsine dimethylarsine: structure given in first source	7.42	2
arsenic Arsenic: A shiny gray element with atomic symbol As, atomic number 33, and atomic weight 75. It occurs throughout the universe, mostly in the form of metallic arsenides. Most forms are toxic. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), arsenic and certain arsenic compounds have been listed as known carcinogens. (From Merck Index, 11th ed)	5.53	22	metalloid atom; pnictogen	micronutrient
sulfur Sulfur: An element that is a member of the chalcogen family. It has an atomic symbol S, atomic number 16, and atomic weight [32.059; 32.076]. It is found in the amino acids cysteine and methionine.	2.43	2	chalcogen; nonmetal atom	macronutrient
cysteine Cysteine: A thiol-containing non-essential amino acid that is oxidized to form CYSTINE.. L-cysteinium : The L-enantiomer of cysteinium.. cysteine : A sulfur-containing amino acid that is propanoic acid with an amino group at position 2 and a sulfanyl group at position 3.	2.01	1	cysteinium	fundamental metabolite
s-adenosylmethionine (R)-S-adenosyl-L-methionine : An S-adenosyl-L-methionine that has R-configuration.. S-adenosyl-L-methionine zwitterion : A zwitterionic tautomer of S-adenosyl-L-methionine arising from shift of the proton from the carboxy group to the amino group.. (R)-S-adenosyl-L-methionine zwitterion : An S-adenosyl-L-methionine zwitterion that has R-configuration; major species at pH 7.3.. (S)-S-adenosyl-L-methionine zwitterion : An S-adenosyl-L-methionine zwitterion that has S-configuration; major species at pH 7.3.. S-adenosyl-L-methionine : A sulfonium compound that is the S-adenosyl derivative of L-methionine. It is an intermediate in the metabolic pathway of methionine.	7.03	1	organic cation; sulfonium compound	coenzyme; cofactor; human metabolite; micronutrient; Mycoplasma genitalium metabolite; nutraceutical; Saccharomyces cerevisiae metabolite
chromated copper arsenate chromated copper arsenate: wood preservative; serves as substrate for trimethylarsine biosynthesis; RN given refers to (Cu(+2)[2:3] salt)	6.96	1

Condition	Relationship Strength	Studies
Cot Death [description not available]	2.01	1
Chromosome-Defective Micronuclei [description not available]	2.01	1
Arsenic Encephalopathy [description not available]	2.4	2
Adverse Drug Event [description not available]	2.02	1
Drug-Related Side Effects and Adverse Reactions Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chemically-induced adverse conditions due to toxicity, DRUG INTERACTIONS, and metabolic effects of pharmaceuticals.	2.02	1
Sensitivity and Specificity Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)	2.44	2
Extravascular Hemolysis [description not available]	1.97	1
Hemolysis The destruction of ERYTHROCYTES by many different causal agents such as antibodies, bacteria, chemicals, temperature, and changes in tonicity.	1.97	1

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