| Assay ID | Title | Year | Journal | Article |
|---|
| AID562013 | Protein binding in mouse plasma at pH 7.4 after 4 hrs | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5
| Novel S-adenosylmethionine decarboxylase inhibitors for the treatment of human African trypanosomiasis. |
| AID562007 | Inhibition of human cytochrome P450 3A4 | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5
| Novel S-adenosylmethionine decarboxylase inhibitors for the treatment of human African trypanosomiasis. |
| AID88931 | In vitro Neoplastic Anti Activity in Human Colon adenocarcinoma HT-29 Cell lines | 2002 | Journal of medicinal chemistry, Nov-07, Volume: 45, Issue:23
| Synthesis and evaluation of analogues of 5'-([(Z)-4-amino-2-butenyl]methylamino)-5'-deoxyadenosine as inhibitors of tumor cell growth, trypanosomal growth, and HIV-1 infectivity. |
| AID214473 | In vitro antitrypanosomal activity against Trypanosomal 110 (EATRO)strain | 2002 | Journal of medicinal chemistry, Nov-07, Volume: 45, Issue:23
| Synthesis and evaluation of analogues of 5'-([(Z)-4-amino-2-butenyl]methylamino)-5'-deoxyadenosine as inhibitors of tumor cell growth, trypanosomal growth, and HIV-1 infectivity. |
| AID562032 | Cmax in mouse brain at 50 mg/kg, ip administered as single dose | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5
| Novel S-adenosylmethionine decarboxylase inhibitors for the treatment of human African trypanosomiasis. |
| AID214483 | In vitro antitrypanosomal activity against Trypanosomal 269 (KETRI)strain | 2002 | Journal of medicinal chemistry, Nov-07, Volume: 45, Issue:23
| Synthesis and evaluation of analogues of 5'-([(Z)-4-amino-2-butenyl]methylamino)-5'-deoxyadenosine as inhibitors of tumor cell growth, trypanosomal growth, and HIV-1 infectivity. |
| AID562015 | Metabolic stability in human assessed as compound remaining plasma after 4 hrs | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5
| Novel S-adenosylmethionine decarboxylase inhibitors for the treatment of human African trypanosomiasis. |
| AID1463515 | Half life in mouse pooled liver microsomes at 1 uM in presence of NADPH by LC/MS/MS method | 2017 | Bioorganic & medicinal chemistry, 10-15, Volume: 25, Issue:20
| Synthesis and evaluation of analogs of 5'-(((Z)-4-amino-2-butenyl)methylamino)-5'-deoxyadenosine (MDL 73811, or AbeAdo) - An inhibitor of S-adenosylmethionine decarboxylase with antitrypanosomal activity. |
| AID94406 | In vitro inhibition of of AdoMetDC derived from L1210 Murine Leukemia Cells. | 2002 | Journal of medicinal chemistry, Nov-07, Volume: 45, Issue:23
| Synthesis and evaluation of analogues of 5'-([(Z)-4-amino-2-butenyl]methylamino)-5'-deoxyadenosine as inhibitors of tumor cell growth, trypanosomal growth, and HIV-1 infectivity. |
| AID123039 | Ratio of number of mice cured to that of total treated with the compound at 50 mg/kg for 7 days | 2002 | Journal of medicinal chemistry, Nov-07, Volume: 45, Issue:23
| Synthesis and evaluation of analogues of 5'-([(Z)-4-amino-2-butenyl]methylamino)-5'-deoxyadenosine as inhibitors of tumor cell growth, trypanosomal growth, and HIV-1 infectivity. |
| AID562017 | Permeability across basolateral to apical side of human Caco2 cells | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5
| Novel S-adenosylmethionine decarboxylase inhibitors for the treatment of human African trypanosomiasis. |
| AID562036 | Antiparasitic activity against Trypanosoma brucei brucei LAB 110 EATRO infected in mouse assessed as mean survival days at 50 mg/kg/day, ip bid for 7 days administered on 1st day of infection and measured through day 40 post infection | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5
| Novel S-adenosylmethionine decarboxylase inhibitors for the treatment of human African trypanosomiasis. |
| AID561999 | Ratio of Kinact to Kiapp for Trypanosoma brucei AdoMetDC expressed in Escherichia coli | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5
| Novel S-adenosylmethionine decarboxylase inhibitors for the treatment of human African trypanosomiasis. |
| AID88844 | In vitro Antineoplastic Activity against Human non small cell lung carcinoma A549 Cell lines | 2002 | Journal of medicinal chemistry, Nov-07, Volume: 45, Issue:23
| Synthesis and evaluation of analogues of 5'-([(Z)-4-amino-2-butenyl]methylamino)-5'-deoxyadenosine as inhibitors of tumor cell growth, trypanosomal growth, and HIV-1 infectivity. |
| AID559246 | Trypanocidal activity against Trypanosoma brucei brucei EATRO after 48 hrs | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8
| Trypanocidal activity of 8-methyl-5'-{[(Z)-4-aminobut-2-enyl]-(methylamino)}adenosine (Genz-644131), an adenosylmethionine decarboxylase inhibitor. |
| AID562008 | Inhibition of human cytochrome P450 2D6 | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5
| Novel S-adenosylmethionine decarboxylase inhibitors for the treatment of human African trypanosomiasis. |
| AID562033 | Antiparasitic activity against Trypanosoma brucei brucei STIB 795 infected in mouse assessed as mean survival days at 50 mg/kg, ip qd for 4 days administered on 3rd day of infection (Rvb = 6.75 days) | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5
| Novel S-adenosylmethionine decarboxylase inhibitors for the treatment of human African trypanosomiasis. |
| AID1463514 | Half life in human pooled liver microsomes at 1 uM in presence of NADPH by LC/MS/MS method | 2017 | Bioorganic & medicinal chemistry, 10-15, Volume: 25, Issue:20
| Synthesis and evaluation of analogs of 5'-(((Z)-4-amino-2-butenyl)methylamino)-5'-deoxyadenosine (MDL 73811, or AbeAdo) - An inhibitor of S-adenosylmethionine decarboxylase with antitrypanosomal activity. |
| AID1463507 | Ratio of drug level in brain to blood in mouse at 10 mg/kg, iv or po after 15 mins to 24 hrs by LC/MS/MS method relative to control | 2017 | Bioorganic & medicinal chemistry, 10-15, Volume: 25, Issue:20
| Synthesis and evaluation of analogs of 5'-(((Z)-4-amino-2-butenyl)methylamino)-5'-deoxyadenosine (MDL 73811, or AbeAdo) - An inhibitor of S-adenosylmethionine decarboxylase with antitrypanosomal activity. |
| AID233235 | Differential selectivity as the ratio of TC50 value to that of EC50 value. | 2002 | Journal of medicinal chemistry, Nov-07, Volume: 45, Issue:23
| Synthesis and evaluation of analogues of 5'-([(Z)-4-amino-2-butenyl]methylamino)-5'-deoxyadenosine as inhibitors of tumor cell growth, trypanosomal growth, and HIV-1 infectivity. |
| AID214477 | In vitro antitrypanosomal activity against Trypanosomal 243 (KETRI)strain | 2002 | Journal of medicinal chemistry, Nov-07, Volume: 45, Issue:23
| Synthesis and evaluation of analogues of 5'-([(Z)-4-amino-2-butenyl]methylamino)-5'-deoxyadenosine as inhibitors of tumor cell growth, trypanosomal growth, and HIV-1 infectivity. |
| AID208078 | Mean survival days against T.b. rhodesiense KETRI 243 tested in mice after intra peritoneal administration at 25 mg/kg for 7 days. | 2002 | Journal of medicinal chemistry, Nov-07, Volume: 45, Issue:23
| Synthesis and evaluation of analogues of 5'-([(Z)-4-amino-2-butenyl]methylamino)-5'-deoxyadenosine as inhibitors of tumor cell growth, trypanosomal growth, and HIV-1 infectivity. |
| AID88774 | In vitro Antineoplastic Activity against Adriamycin resistant Human Breast adenocarcinoma MCF7-Adr Cell lines | 2002 | Journal of medicinal chemistry, Nov-07, Volume: 45, Issue:23
| Synthesis and evaluation of analogues of 5'-([(Z)-4-amino-2-butenyl]methylamino)-5'-deoxyadenosine as inhibitors of tumor cell growth, trypanosomal growth, and HIV-1 infectivity. |
| AID279551 | Antiproliferative activity against Leishmania donovani DI700 promastigotes in presence of 100 uM spermidine | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
| Leishmania donovani polyamine biosynthetic enzyme overproducers as tools to investigate the mode of action of cytotoxic polyamine analogs. |
| AID562012 | Protein binding in human plasma at pH 7.4 after 4 hrs | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5
| Novel S-adenosylmethionine decarboxylase inhibitors for the treatment of human African trypanosomiasis. |
| AID352513 | Cmax in brain of single dose ip administered mouse | 2009 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 19, Issue:11
| Discovery of new S-adenosylmethionine decarboxylase inhibitors for the treatment of Human African Trypanosomiasis (HAT). |
| AID559249 | Ratio of Kinact to Kiapp for Trypanosoma brucei rhodesiense AdoMetDC | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8
| Trypanocidal activity of 8-methyl-5'-{[(Z)-4-aminobut-2-enyl]-(methylamino)}adenosine (Genz-644131), an adenosylmethionine decarboxylase inhibitor. |
| AID214481 | In vitro antitrypanosomal activity against Trypanosomal 243 As 10e-3 (KETRI)strain | 2002 | Journal of medicinal chemistry, Nov-07, Volume: 45, Issue:23
| Synthesis and evaluation of analogues of 5'-([(Z)-4-amino-2-butenyl]methylamino)-5'-deoxyadenosine as inhibitors of tumor cell growth, trypanosomal growth, and HIV-1 infectivity. |
| AID352505 | Inhibition of Trypanosoma brucei AdoMetDC assessed as ratio of Kinact to Ki(apparent) | 2009 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 19, Issue:11
| Discovery of new S-adenosylmethionine decarboxylase inhibitors for the treatment of Human African Trypanosomiasis (HAT). |
| AID279549 | Antiproliferative activity against Leishmania donovani DI700 promastigotes overproducing ADOMETDC enzyme | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
| Leishmania donovani polyamine biosynthetic enzyme overproducers as tools to investigate the mode of action of cytotoxic polyamine analogs. |
| AID559248 | Trypanocidal activity against Trypanosoma brucei rhodesiense KETRI2538 after 48 hrs | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8
| Trypanocidal activity of 8-methyl-5'-{[(Z)-4-aminobut-2-enyl]-(methylamino)}adenosine (Genz-644131), an adenosylmethionine decarboxylase inhibitor. |
| AID261568 | Antitrypanosomal activity against Trypanosoma brucei | 2006 | Journal of medicinal chemistry, Mar-23, Volume: 49, Issue:6
| Antitrypanosomal activity of 5'-deoxy-5'-(iodomethylene)adenosine and related 6-N-cyclopropyladenosine analogues. |
| AID208073 | Mean survival days against T.b. peritoneal administration at 50 mg/kg for 3 days. | 2002 | Journal of medicinal chemistry, Nov-07, Volume: 45, Issue:23
| Synthesis and evaluation of analogues of 5'-([(Z)-4-amino-2-butenyl]methylamino)-5'-deoxyadenosine as inhibitors of tumor cell growth, trypanosomal growth, and HIV-1 infectivity. |
| AID208072 | Mean survival days against T.b. peritoneal administration at 25 mg/kg for 3 days. | 2002 | Journal of medicinal chemistry, Nov-07, Volume: 45, Issue:23
| Synthesis and evaluation of analogues of 5'-([(Z)-4-amino-2-butenyl]methylamino)-5'-deoxyadenosine as inhibitors of tumor cell growth, trypanosomal growth, and HIV-1 infectivity. |
| AID562006 | Metabolic stability in human hepatocytes assessed as intrinsic clearance up to 45 mins by LC/MS/MS analysis | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5
| Novel S-adenosylmethionine decarboxylase inhibitors for the treatment of human African trypanosomiasis. |
| AID562016 | Permeability across apical to basolateral side of human Caco2 cells | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5
| Novel S-adenosylmethionine decarboxylase inhibitors for the treatment of human African trypanosomiasis. |
| AID562009 | Inhibition of human cytochrome P450 2C9 | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5
| Novel S-adenosylmethionine decarboxylase inhibitors for the treatment of human African trypanosomiasis. |
| AID123034 | Ratio of number of mice cured to that of total treated with the compound at 100 mg/kg for 7 days | 2002 | Journal of medicinal chemistry, Nov-07, Volume: 45, Issue:23
| Synthesis and evaluation of analogues of 5'-([(Z)-4-amino-2-butenyl]methylamino)-5'-deoxyadenosine as inhibitors of tumor cell growth, trypanosomal growth, and HIV-1 infectivity. |
| AID89009 | In vitro Antineoplastic Activity against Human ovarian carcinoma A121 Cell lines | 2002 | Journal of medicinal chemistry, Nov-07, Volume: 45, Issue:23
| Synthesis and evaluation of analogues of 5'-([(Z)-4-amino-2-butenyl]methylamino)-5'-deoxyadenosine as inhibitors of tumor cell growth, trypanosomal growth, and HIV-1 infectivity. |
| AID352512 | Cmax in blood of single dose ip administered mouse | 2009 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 19, Issue:11
| Discovery of new S-adenosylmethionine decarboxylase inhibitors for the treatment of Human African Trypanosomiasis (HAT). |
| AID562001 | Kinetic solubility in dimethyl sulfoxide at pH 7.4 after 16 to 24 hrs by UV spectrophotometry | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5
| Novel S-adenosylmethionine decarboxylase inhibitors for the treatment of human African trypanosomiasis. |
| AID352510 | AUC in brain of single dose ip administered mouse | 2009 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 19, Issue:11
| Discovery of new S-adenosylmethionine decarboxylase inhibitors for the treatment of Human African Trypanosomiasis (HAT). |
| AID123037 | Ratio of number of mice cured to that of total treated with the compound at 25 mg/kg for 7 days | 2002 | Journal of medicinal chemistry, Nov-07, Volume: 45, Issue:23
| Synthesis and evaluation of analogues of 5'-([(Z)-4-amino-2-butenyl]methylamino)-5'-deoxyadenosine as inhibitors of tumor cell growth, trypanosomal growth, and HIV-1 infectivity. |
| AID208077 | Mean survival days against T.b. rhodesiense KETRI 243 tested in mice after intra peritoneal administration at 100 mg/kg for 7 days. | 2002 | Journal of medicinal chemistry, Nov-07, Volume: 45, Issue:23
| Synthesis and evaluation of analogues of 5'-([(Z)-4-amino-2-butenyl]methylamino)-5'-deoxyadenosine as inhibitors of tumor cell growth, trypanosomal growth, and HIV-1 infectivity. |
| AID81441 | In Vitro Anti-HIV activity of the compound | 2002 | Journal of medicinal chemistry, Nov-07, Volume: 45, Issue:23
| Synthesis and evaluation of analogues of 5'-([(Z)-4-amino-2-butenyl]methylamino)-5'-deoxyadenosine as inhibitors of tumor cell growth, trypanosomal growth, and HIV-1 infectivity. |
| AID208071 | Mean survival days against T.b. peritoneal administration at 10 mg/kg for 3 days. | 2002 | Journal of medicinal chemistry, Nov-07, Volume: 45, Issue:23
| Synthesis and evaluation of analogues of 5'-([(Z)-4-amino-2-butenyl]methylamino)-5'-deoxyadenosine as inhibitors of tumor cell growth, trypanosomal growth, and HIV-1 infectivity. |
| AID279548 | Antiproliferative activity against Leishmania donovani DI700 promastigotes overproducing SPDSYN enzyme | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
| Leishmania donovani polyamine biosynthetic enzyme overproducers as tools to investigate the mode of action of cytotoxic polyamine analogs. |
| AID562035 | Antiparasitic activity against Trypanosoma brucei brucei LAB 110 EATRO infected in mouse assessed as mean survival days at 50 mg/kg/day, ip bid for 4 days administered on 1st day of infection and measured through day 40 post infection | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5
| Novel S-adenosylmethionine decarboxylase inhibitors for the treatment of human African trypanosomiasis. |
| AID562004 | Metabolic stability in human liver microsomes assessed as intrinsic clearance up to 45 mins by LC/MS/MS analysis | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5
| Novel S-adenosylmethionine decarboxylase inhibitors for the treatment of human African trypanosomiasis. |
| AID1463511 | Antitrypanosomal activity against Trypanosoma brucei Lister 427 bloodstream forms assessed as inhibition of parasite growth incubated for 48 hrs by ATP-bioluminescence cell viability assay | 2017 | Bioorganic & medicinal chemistry, 10-15, Volume: 25, Issue:20
| Synthesis and evaluation of analogs of 5'-(((Z)-4-amino-2-butenyl)methylamino)-5'-deoxyadenosine (MDL 73811, or AbeAdo) - An inhibitor of S-adenosylmethionine decarboxylase with antitrypanosomal activity. |
| AID562039 | Partition coefficient in RBCs | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5
| Novel S-adenosylmethionine decarboxylase inhibitors for the treatment of human African trypanosomiasis. |
| AID562014 | Metabolic stability in rat plasma assessed as compound remaining after 4 hrs | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5
| Novel S-adenosylmethionine decarboxylase inhibitors for the treatment of human African trypanosomiasis. |
| AID562029 | Half life in mouse at 50 mg/kg, ip administered as single dose | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5
| Novel S-adenosylmethionine decarboxylase inhibitors for the treatment of human African trypanosomiasis. |
| AID352509 | Half life in single dose ip administered mouse | 2009 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 19, Issue:11
| Discovery of new S-adenosylmethionine decarboxylase inhibitors for the treatment of Human African Trypanosomiasis (HAT). |
| AID352507 | Antitrypanosomal activity against Trypanosoma brucei brucei | 2009 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 19, Issue:11
| Discovery of new S-adenosylmethionine decarboxylase inhibitors for the treatment of Human African Trypanosomiasis (HAT). |
| AID123036 | Ratio of number of mice cured to that of total treated with the compound at 25 mg/kg for 3 days | 2002 | Journal of medicinal chemistry, Nov-07, Volume: 45, Issue:23
| Synthesis and evaluation of analogues of 5'-([(Z)-4-amino-2-butenyl]methylamino)-5'-deoxyadenosine as inhibitors of tumor cell growth, trypanosomal growth, and HIV-1 infectivity. |
| AID559247 | Trypanocidal activity against Trypanosoma brucei rhodesiense KETRI243 after 48 hrs | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8
| Trypanocidal activity of 8-methyl-5'-{[(Z)-4-aminobut-2-enyl]-(methylamino)}adenosine (Genz-644131), an adenosylmethionine decarboxylase inhibitor. |
| AID1463506 | Antitrypanosomal activity against Trypanosoma brucei brucei | 2017 | Bioorganic & medicinal chemistry, 10-15, Volume: 25, Issue:20
| Synthesis and evaluation of analogs of 5'-(((Z)-4-amino-2-butenyl)methylamino)-5'-deoxyadenosine (MDL 73811, or AbeAdo) - An inhibitor of S-adenosylmethionine decarboxylase with antitrypanosomal activity. |
| AID562002 | Permeability of the compound after 4 hrs by PAMPA assay | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5
| Novel S-adenosylmethionine decarboxylase inhibitors for the treatment of human African trypanosomiasis. |
| AID352508 | AUC in blood of single dose ip administered mouse | 2009 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 19, Issue:11
| Discovery of new S-adenosylmethionine decarboxylase inhibitors for the treatment of Human African Trypanosomiasis (HAT). |
| AID562028 | AUC in mouse brain at 50 mg/kg, ip administered as single dose | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5
| Novel S-adenosylmethionine decarboxylase inhibitors for the treatment of human African trypanosomiasis. |
| AID561998 | Antiparasitic activity against Trypanosoma brucei rhodesiense STIB 900 clone after 72 hrs by Alamar blue assay | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5
| Novel S-adenosylmethionine decarboxylase inhibitors for the treatment of human African trypanosomiasis. |
| AID279550 | Antiproliferative activity against Leishmania donovani DI700 promastigotes in presence of 100 uM putrescine | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
| Leishmania donovani polyamine biosynthetic enzyme overproducers as tools to investigate the mode of action of cytotoxic polyamine analogs. |
| AID279547 | Antiproliferative activity against Leishmania donovani DI700 promastigotes overproducing ODC enzyme | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
| Leishmania donovani polyamine biosynthetic enzyme overproducers as tools to investigate the mode of action of cytotoxic polyamine analogs. |
| AID279546 | Antiproliferative activity against Leishmania donovani DI700 promastigotes | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
| Leishmania donovani polyamine biosynthetic enzyme overproducers as tools to investigate the mode of action of cytotoxic polyamine analogs. |
| AID352506 | Antitrypanosomal activity against Trypanosoma brucei rhodesiense | 2009 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 19, Issue:11
| Discovery of new S-adenosylmethionine decarboxylase inhibitors for the treatment of Human African Trypanosomiasis (HAT). |
| AID46624 | Concentration that causes morphological changes in noninfected CEM-SS cells | 2002 | Journal of medicinal chemistry, Nov-07, Volume: 45, Issue:23
| Synthesis and evaluation of analogues of 5'-([(Z)-4-amino-2-butenyl]methylamino)-5'-deoxyadenosine as inhibitors of tumor cell growth, trypanosomal growth, and HIV-1 infectivity. |
| AID352515 | Distribution coefficient, log D at pH 7.4 by shake flask method | 2009 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 19, Issue:11
| Discovery of new S-adenosylmethionine decarboxylase inhibitors for the treatment of Human African Trypanosomiasis (HAT). |
| AID562010 | Inhibition of human cytochrome P450 2C19 | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5
| Novel S-adenosylmethionine decarboxylase inhibitors for the treatment of human African trypanosomiasis. |
| AID1463509 | Inhibition of Trypanosoma brucei AdoMetDC without pre-incubation for 30 mins before AdoMet substrate addition by RapidFire-mass spectrometry | 2017 | Bioorganic & medicinal chemistry, 10-15, Volume: 25, Issue:20
| Synthesis and evaluation of analogs of 5'-(((Z)-4-amino-2-butenyl)methylamino)-5'-deoxyadenosine (MDL 73811, or AbeAdo) - An inhibitor of S-adenosylmethionine decarboxylase with antitrypanosomal activity. |
| AID562030 | Ratio of AUC in brain to blood for mouse at 50 mg/kg, ip administered as single dose | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5
| Novel S-adenosylmethionine decarboxylase inhibitors for the treatment of human African trypanosomiasis. |
| AID562038 | Metabolic stability in rat whole blood assessed as compound remaining | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5
| Novel S-adenosylmethionine decarboxylase inhibitors for the treatment of human African trypanosomiasis. |
| AID1463505 | Inhibition of His-tagged Trypanosoma brucei AdoMetDC expressed in Escherichia coli pre-incubated for 1 to 22 mins before AdoMet substrate addition | 2017 | Bioorganic & medicinal chemistry, 10-15, Volume: 25, Issue:20
| Synthesis and evaluation of analogs of 5'-(((Z)-4-amino-2-butenyl)methylamino)-5'-deoxyadenosine (MDL 73811, or AbeAdo) - An inhibitor of S-adenosylmethionine decarboxylase with antitrypanosomal activity. |
| AID562042 | Antiparasitic activity against Trypanosoma brucei brucei LAB 110 EATRO infected in mouse assessed as parasitemia cure incidence at 50 mg/kg/day, ip bid for 4 days administered on 1st day of infection and measured through day 40 post infection | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5
| Novel S-adenosylmethionine decarboxylase inhibitors for the treatment of human African trypanosomiasis. |
| AID562011 | Inhibition of human cytochrome P450 1A2 | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5
| Novel S-adenosylmethionine decarboxylase inhibitors for the treatment of human African trypanosomiasis. |
| AID352514 | Antitrypanosomal activity against Trypanosoma brucei brucei infected mouse assessed as reduction in parasitemia | 2009 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 19, Issue:11
| Discovery of new S-adenosylmethionine decarboxylase inhibitors for the treatment of Human African Trypanosomiasis (HAT). |
| AID352511 | Ratio of AUC in brain to blood in single dose ip administered mouse | 2009 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 19, Issue:11
| Discovery of new S-adenosylmethionine decarboxylase inhibitors for the treatment of Human African Trypanosomiasis (HAT). |
| AID1463513 | Apparent permeability in MDCK2-MDR1 cells at 3 uM incubated for 1 hr in presence of P-glycoprotein inhibitor GF120918 by LC/MS/MS method | 2017 | Bioorganic & medicinal chemistry, 10-15, Volume: 25, Issue:20
| Synthesis and evaluation of analogs of 5'-(((Z)-4-amino-2-butenyl)methylamino)-5'-deoxyadenosine (MDL 73811, or AbeAdo) - An inhibitor of S-adenosylmethionine decarboxylase with antitrypanosomal activity. |
| AID562000 | Ratio of Kinact to Kiapp for human AdoMetDC expressed in Escherichia coli | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5
| Novel S-adenosylmethionine decarboxylase inhibitors for the treatment of human African trypanosomiasis. |
| AID562031 | Cmax in mouse blood at 50 mg/kg, ip administered as single dose | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5
| Novel S-adenosylmethionine decarboxylase inhibitors for the treatment of human African trypanosomiasis. |
| AID562005 | Metabolic stability in rat hepatocytes assessed as intrinsic clearance up to 45 mins by LC/MS/MS analysis | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5
| Novel S-adenosylmethionine decarboxylase inhibitors for the treatment of human African trypanosomiasis. |
| AID123038 | Ratio of number of mice cured to that of total treated with the compound at 50 mg/kg for 3 days | 2002 | Journal of medicinal chemistry, Nov-07, Volume: 45, Issue:23
| Synthesis and evaluation of analogues of 5'-([(Z)-4-amino-2-butenyl]methylamino)-5'-deoxyadenosine as inhibitors of tumor cell growth, trypanosomal growth, and HIV-1 infectivity. |
| AID208079 | Mean survival days against T.b. rhodesiense KETRI 243 tested in mice after intra peritoneal administration at 50 mg/kg for 7 days. | 2002 | Journal of medicinal chemistry, Nov-07, Volume: 45, Issue:23
| Synthesis and evaluation of analogues of 5'-([(Z)-4-amino-2-butenyl]methylamino)-5'-deoxyadenosine as inhibitors of tumor cell growth, trypanosomal growth, and HIV-1 infectivity. |
| AID123035 | Ratio of number of mice cured to that of total treated with the compound at 10 mg/kg for 3 days | 2002 | Journal of medicinal chemistry, Nov-07, Volume: 45, Issue:23
| Synthesis and evaluation of analogues of 5'-([(Z)-4-amino-2-butenyl]methylamino)-5'-deoxyadenosine as inhibitors of tumor cell growth, trypanosomal growth, and HIV-1 infectivity. |
| AID88777 | In vitro Neoplastic Anti Activity against Human Breast adenocarcinoma MCF-7 Cell lines | 2002 | Journal of medicinal chemistry, Nov-07, Volume: 45, Issue:23
| Synthesis and evaluation of analogues of 5'-([(Z)-4-amino-2-butenyl]methylamino)-5'-deoxyadenosine as inhibitors of tumor cell growth, trypanosomal growth, and HIV-1 infectivity. |
| AID562027 | AUC in mouse blood at 50 mg/kg, ip administered as single dose | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5
| Novel S-adenosylmethionine decarboxylase inhibitors for the treatment of human African trypanosomiasis. |
| AID1463504 | Inhibition of Trypanosoma brucei AdoMetDC pre-incubated for 30 mins before AdoMet substrate addition by RapidFire-mass spectrometry | 2017 | Bioorganic & medicinal chemistry, 10-15, Volume: 25, Issue:20
| Synthesis and evaluation of analogs of 5'-(((Z)-4-amino-2-butenyl)methylamino)-5'-deoxyadenosine (MDL 73811, or AbeAdo) - An inhibitor of S-adenosylmethionine decarboxylase with antitrypanosomal activity. |
| AID562003 | Metabolic stability in rat liver microsomes assessed as intrinsic clearance up to 45 mins by LC/MS/MS analysis | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5
| Novel S-adenosylmethionine decarboxylase inhibitors for the treatment of human African trypanosomiasis. |
| AID1413032 | Growth inhibition of Plasmodium falciparum ITG2 infected in human erythrocytes assessed as reduction in [3H]-isoleucine incorporation pretreated for 24 hrs followed by [3H]-isoleucine addition and measured after 18 hrs by liquid scintillation counting met | 2018 | MedChemComm, Jul-01, Volume: 9, Issue:7
| Synthesis and antiplasmodial activity of purine-based |
| AID1413031 | Growth inhibition of Plasmodium falciparum D6 infected in human erythrocytes assessed as reduction in [3H]-isoleucine incorporation pretreated for 24 hrs followed by [3H]-isoleucine addition and measured after 18 hrs by liquid scintillation counting metho | 2018 | MedChemComm, Jul-01, Volume: 9, Issue:7
| Synthesis and antiplasmodial activity of purine-based |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |