Page last updated: 2024-09-27

Hepatitis E

Acute INFLAMMATION of the LIVER in humans; caused by HEPATITIS E VIRUS, a non-enveloped single-stranded RNA virus. Similar to HEPATITIS A, its incubation period is 15-60 days and is enterically transmitted, usually by fecal-oral transmission.

Synonyms(1)

Synonym
Hepatitis E

Research Excerpts

Overview

ExcerptReference
"While hepatitis E is not endemic in the United States, it should be considered in the differential diagnosis of the traveler with non-A, non-B hepatitis."( Herrera, JL, 1993)
"Chronic forms of hepatitis E are not known."( Hiller, J; Knödler, B; Kühnl, L; Löliger, CC, 1994)
"The course of hepatitis E is usually benign, further diagnostic studies are rarely needed, and the treatment is usually symptomatic."( Bulang, T; Porst, H, 2000)
"Diagnosis of hepatitis E is usually made by detection of specific IgM antibody, which disappears rapidly over a few months; IgG anti-HEV persists for at least a few years."( Aggarwal, R; Kamili, S; Krawczynski, K, 2000)
"Hepatitis E is endemic in India."( Arankalle, VA; Chadha, MS; Chobe, LP; Joshi, MV; Kundu, B; Walimbe, AM, 2002)
"Hepatitis E is endemic in India."( Arankalle, VA; Chobe, LP; Jacob, GP; Walimbe, AM; Yergolkar, PN, 2003)
"Vaccines for hepatitis E are under development."( Siegl, G, 2004)
"Hepatitis E is a self-limited and enterically transmitted acute viral hepatitis that occurs from epidemic outbreaks of developing countries and sporadic hepatitis in non-endemic areas."( Bae, SH; Choi, JY; Jang, JW; Kim, CW; Kim, HS; Kim, JD; Kim, SS; Yeo, CD; Yoon, SK, 2004)
"Hepatitis E is endemic to the Indian subcontinent, with a seroprevalence of 4-20%, and more than 25% of acute viral hepatitis is due to HEV."( Chakraborti, A; Chawla, YK; Kumar, S; Pujhari, SK; Ratho, RK, 2010)
"Hepatitis E is the main cause of enterically transmitted non-A, non-B hepatitis in developing countries."( Begum, N; Husain, SA; Kar, P; Polipalli, SK, 2010)
"Pathogenesis of hepatitis E is poorly understood."( Arankalle, VA; Mishra, N, 2011)
"Acute hepatitis E is associated with a higher rate of mortality as compared to hepatitis A or B infections in some series."( Borentain, P; Colson, P; Gerolami, R; Motte, A; Raissouni, F; Solas, C, 2011)
"Hepatitis E is a water-borne pathogen transmitted by the fecal-oral route."( Chaudhry, SA; Koren, G; Verma, N, 2015)
"Autochthonous hepatitis E is increasingly being recognized in industrialized countries, including Japan."( Honda, M; Nagashima, S; Ohnishi, H; Okamoto, H; Sugawara, K; Takahashi, M; Yazaki, Y, 2015)
"Hepatitis E is a systemic disease affecting the liver predominantly and caused by infection with the hepatitis E virus (HEV)."( Khuroo, MS, 2016)
"Hepatitis E is the chief causative organism causing fulminant hepatic failure in pregnant women in Central India."( Ganga, D; Jatav, OP; Mishra, V; Sahai, S, 2015)
"Acute hepatitis E is usually self-limiting and does not require specific treatment."( Aggarwal, R; Dalton, HR; Izopet, J; Kamar, N; Labrique, A; Pavio, N; Wedemeyer, H, 2017)
"Hepatitis E is caused by infection with hepatitis E virus (HEV), which has four well-known genotypes."( Aggarwal, R; Chetri, K; Dadhich, S; Dixit, VK; Goel, A; Gupta, N; Sarangi, AN, 2018)
"Hepatitis E is associated with mortality and liver-related morbidity in patients with haematological malignancy."( Aitken, C; Alric, L; Ayuk, F; Bettinger, D; Binder, M; Cornelissen, JJ; de Man, RA; Giordani, MT; Lohse, AW; Mallet, V; Pischke, S; Schlabe, S; Schnitzler, P; Spengler, U; Thimme, R; von Felden, J; Xhaard, A, 2019)
"Hepatitis E is an infectious disease due to inflammation of the liver caused by hepatitis E virus (HEV) and represents one of the most common causes of acute hepatitis and jaundice in the world."( Carubbi, F; Cipriani, P; Di Bartolomeo, S; Giacomelli, R; Grimaldi, A; Marola, L; Picchi, G; Ricciardi, A, 2019)
"Hepatitis E is viral hepatitis caused by infection with the hepatitis E virus (HEV)."( Hon, KLE; Leung, AKC; Sridhar, S; Wong, AHC, 2023)
"Chronic hepatitis E is mostly caused by zoonotic genotype 3 HEV (HEV-3), and HEV variants from rabbits (HEV-3ra) are closely related to human HEV-3."( Hassebroek, AM; Heffron, CL; LeRoith, T; Li, W; Mahsoub, HM; Meng, XJ; Tian, D; Wang, B, 2023)

Context

ExcerptReference
"Hepatitis E has been the predominant type of acute hepatitis in Nepal both in adults and children, in sporadic and epidemic forms."( Cohen, SJ; Gouvea, V; Hoke, CH; Innis, BL; Myint, KS; Shrestha, MP; Snellings, N; Vaughn, DW; Warren, RL, 1997)
"Hepatitis E has a vast distribution throughout the world and manifests itself either in epidemic or endemic-sporadic form in many poor countries."( Buisson, Y; Debord, T, 1998)
"Diagnosis of acute hepatitis E has been based in many clinics predominantly on detection of anti-HEV (hepatitis E virus) antibody."( Fan, J; Harrison, TJ; Li, L; Ma, H; Song, A; Wang, Q; Wang, Y; Zhang, C; Zhao, C, 2009)
"Autochthonous hepatitis E has been observed with growing incidence in industrialized countries."( Lohse, AW; Lütgehetmann, M; Pischke, S; Polywka, S; Quaas, A; Sebode, M; Wege, H, 2014)
"Chronic hepatitis E has been described several times in strongly immunosuppressed HIV-patients."( Herbst, H; Ingiliz, P; Mayr, C; Obermeier, M; Pischke, S; Polywka, S, 2016)
"Although hepatitis E has emerged as a global health issue, there is limited knowledge of its infection biology and no FDA-approved medication is available."( Berkhout, B; Brandsma, JH; Debing, Y; Herrera Carrillo, E; Neyts, J; Pan, Q; Peppelenbosch, MP; Poot, RA; Wang, W; Wang, Y; Xu, L; Yin, Y; Zhou, X, 2017)
"Management of hepatitis E has evolved over time, with the first step being a reduction of immunosuppression followed by treatment with ribavirin."( Dolman, G; Gelson, W; Mohsen, A; Robins, A; Williams, S, 2022)
"Hepatitis E has mainly a fecal-oral transmission route."( Hon, KLE; Leung, AKC; Sridhar, S; Wong, AHC, 2023)

Treatment

ExcerptReference
"Pegylated-interferon has been used for treating hepatitis E virus infection."( Alric, L; Izopet, J; Kamar, N; Peron, JM; Rostaing, L, 2015)
"Ribavirin is efficient at treating chronic hepatitis E virus infection in solid-organ transplant patients."( Abravanel, F; Broué, P; Cardeau-Desangles, I; Cointault, O; Del Bello, A; Dörr, G; Esposito, L; Goin, AL; Guitard, J; Izopet, J; Kamar, N; Lavayssière, L; Lhomme, S; Metsu, D; Nogier, MB; Ribes, D; Rostaing, L; Sauné, K, 2015)
"Ribavirin has been used successfully to treat acute hepatitis E in high-risk patients."( Dalton, HR; Kamar, N, 2016)
"Ribavirin is an effective treatment for hepatitis E, but further studies are required to determine which other antiviral agents are of clinical utility in treating HEV in the minority of patients who do not respond to ribavirin."( Dalton, HR; Kamar, N, 2016)
"Ribavirin is currently recommended for treating chronic hepatitis E virus (HEV) infection."( Abravanel, F; Barbet, C; Behrendt, P; Cassuto, E; Choi, M; Coilly, A; Couzi, L; De Man, RA; Dharancy, S; Donnelly, MC; Dumortier, J; Elsharkawy, AM; Etienne, I; Figueres, L; Garrouste, C; Glowaki, F; Hillaire, S; Hofmann, J; Horvatits, T; Izopet, J; Kamar, N; Lebray, P; Marion, O; Matignon, M; Minello, A; Moal, V; Mousson, C; Pageaux, GP; Perrin, P; Radenne, S; Rerolle, JP; Riezebos-Brilman, A; Sayegh, J; Scemla, A, 2020)

Research

Studies (541)

TimeframeStudies, This Condition (%)All Conditions %
pre-19900 (0.00)23.3326
1990's80 (14.79)12.5806
2000's76 (14.05)18.1394
2010's284 (52.50)28.8240
2020's101 (18.67)9.53
DrugIndicatedRelationship StrengthStudiesTrials
adenine0low30
carbamates0low10
salicylic acid0low10
formaldehyde0low10
nitrates0low10
triphosphoric acid0low10
pyrazinamide0low10
urea0low10
1-anilino-8-naphthalenesulfonate0low30
acetaminophen0low30
azathioprine0low50
carbamazepine0low10
dyphylline0low10
flumazenil0low10
isoniazid0low10
lansoprazole0low10
leflunomide0low10
propranolol0low10
thalidomide0low10
ticlopidine0low10
prednisolone0low110
prednisone0low10
methylene blue0low10
leucine0low10
valine0low10
taurocholic acid0low10
methylprednisolone0low40
thiazoles0low10
pyrazines0low10
glycocholic acid0low10
alpha-aminopyridine0low10
acetylcysteine0low20
deoxycytidine0low10
durapatite0low10
lead sulfide0low10
gold0low40
sodium nitrate0low10
chlorine0low10
aluminum sulfate0low10
trolamine salicylate0low20
tetradecanoylphorbol acetate0low30
carbimazole0low10
cetylpyridinium chloride anhydrous0low10
ursodeoxycholic acid0low20
ribavirin0medium1811
flupirtine0low10
adefovir0low10
clopidogrel0low10
gemcitabine0low10
lamivudine0low10
adenosine0low10
thiazolyl blue0low10
2-(n-cyclohexylamino)ethanesulfonic acid0low10
bendamustine hydrochloride0low10
d-aspartic acid0low10
tebuconazole0low10
homocysteine0low10
pyrimidine dimers0low10
artesunic acid0low10
fingolimod hydrochloride0low30
methotrexate0low40
organophosphonates0low20
dibenzheptropine0low10
lenalidomide0low10
ritonavir0low10
leupeptins0low10
phalloidine0low10
tacrolimus0low40
cocaine0low20
mycophenolic acid0low40
zithromax0low10
benzyloxycarbonylleucyl-leucyl-leucine aldehyde0low10
tenofovir0low20
favipiravir0low10
dimethyl fumarate0low10
digoxin0low10
tamoxifen0low10
sphingosine0low10
bilirubin0medium381
linoleic acid0low10
furylfuramide0low10
sirolimus0low30
brefeldin a0low10
lead0low10
arsenic0low10
everolimus0low10
sq-233770low20
g(m2) ganglioside0low20
g(m1) ganglioside0low10
silvestrol0low30
dextrothyroxine0low10
clove0low10
oligonucleotides0low10
chitosan0low20
sodium nitrite0low10
pci 327650low10
golgicide a0low10
bms-7900520low10
baricitinib0low10
piperidines0low10
nitd0080low10
sofosbuvir0medium171
tuftsin0low10
sybr green i0low10
rome0low10
norgestrel0low10
cyclosporine0medium51
exudates0low40
entecavir0low10
guanosine triphosphate0low10
guanine0low10
rifampin0low10
ganciclovir0low20
valganciclovir0low10
leptin0low10

Protein Targets (1,351)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Chain B, pheromone binding protein0011
Chain A, pheromone binding protein0011
Chain A, JmjC domain-containing histone demethylation protein 3A6006
Chain A, RNA-directed RNA polymerase NS50101
acid sphingomyelinase3003
thioredoxin reductase140014
USP1 protein, partial180018
TDP1 protein330033
vitamin D3 receptor isoform VDRA120012
importin subunit beta-1 isoform 13003
flap endonuclease 17007
serine/threonine-protein kinase PLK12002
snurportin-13003
peptidyl-prolyl cis-trans isomerase NIMA-interacting 14004
GTP-binding nuclear protein Ran isoform 12002
DNA polymerase eta isoform 14004
DNA polymerase iota isoform a (long)110011
urokinase-type plasminogen activator precursor6006
plasminogen precursor6006
urokinase plasminogen activator surface receptor precursor6006
geminin320032
DNA polymerase kappa isoform 18008
fibroblast growth factor 22 isoform 1 precursor0001
Mitogen-activated protein kinase 130101
Beta-lactamase0101
Transthyretin0011
Fatty acid-binding protein, intestinal0112
Fatty acid-binding protein, adipocyte0314
Cyclin-A20101
Cannabinoid receptor 10011
Cyclin-dependent kinase 20268
Choline O-acetyltransferase0101
Mitogen-activated protein kinase 120101
Guanine nucleotide-binding protein G4004
Fatty acid-binding protein 50112
Fatty acid-binding protein 50011
Mitogen-activated protein kinase 110145
Mitogen-activated protein kinase 140145
RAR-related orphan receptor gamma230023
ATAD5 protein, partial110011
GLS protein7007
Microtubule-associated protein tau150015
Smad38008
aldehyde dehydrogenase 1 family, member A1190019
thyroid stimulating hormone receptor110011
nuclear receptor subfamily 1, group I, member 3200020
progesterone receptor190019
EWS/FLI fusion protein200020
retinoic acid nuclear receptor alpha variant 1250025
retinoid X nuclear receptor alpha260026
estrogen-related nuclear receptor alpha270027
estrogen nuclear receptor alpha410041
peroxisome proliferator activated receptor gamma210021
aryl hydrocarbon receptor120012
chromobox protein homolog 1140014
thyroid hormone receptor beta isoform 2280028
peripheral myelin protein 22100010
cytochrome P450 3A4 isoform 1150015
Gamma-aminobutyric acid receptor subunit pi153119
ATP-binding cassette sub-family C member 3026026
Multidrug resistance-associated protein 4028029
Solute carrier family 22 member 60405
Carbonic anhydrase 120202
UDP-glucuronosyltransferase 1A90002
Bile salt export pump013014
Voltage-dependent calcium channel gamma-2 subunit180018
Bile salt export pump036038
Cytochrome P450 2B10001
Cytochrome P450 1A10001
Carbonic anhydrase 10606
Carbonic anhydrase 20617
Myoglobin0101
Cytochrome P450 1A10012
Cytochrome P450 1A20709
Prostaglandin G/H synthase 10202
Carbonic anhydrase 30202
Cytochrome P450 3A4015018
Cytochrome P450 2D6010011
Cytochrome P450 2C9 011114
Polyunsaturated fatty acid lipoxygenase ALOX150202
Gamma-aminobutyric acid receptor subunit beta-1153119
Sulfotransferase 1A1 0001
Gamma-aminobutyric acid receptor subunit delta153119
Gamma-aminobutyric acid receptor subunit gamma-2153119
UDP-glucuronosyltransferase 1-60001
Glutamate receptor 2181019
Gamma-aminobutyric acid receptor subunit alpha-5153119
Gamma-aminobutyric acid receptor subunit alpha-3153119
Arachidonate 5-lipoxygenase-activating protein0101
UDP-glucuronosyltransferase 1A1 0103
Carbonic anhydrase 40404
Prostaglandin G/H synthase 10404
Carbonic anhydrase 60202
Gamma-aminobutyric acid receptor subunit gamma-1153119
Gamma-aminobutyric acid receptor subunit alpha-2153119
Gamma-aminobutyric acid receptor subunit alpha-4153119
Gamma-aminobutyric acid receptor subunit gamma-3153119
Gamma-aminobutyric acid receptor subunit alpha-6153119
Carbonic anhydrase 5A, mitochondrial0303
Prostaglandin G/H synthase 20203
Carbonic anhydrase 70202
Nuclear receptor ROR-gamma91111
Cytochrome P450 2J20606
Gamma-aminobutyric acid receptor subunit alpha-1153119
Gamma-aminobutyric acid receptor subunit beta-3153119
Gamma-aminobutyric acid receptor subunit beta-2153119
Carbonic anhydrase 90202
GABA theta subunit153119
Canalicular multispecific organic anion transporter 1026026
Carbonic anhydrase 150303
Carbonic anhydrase 130202
Gamma-aminobutyric acid receptor subunit epsilon153119
Carbonic anhydrase 140202
Carbonic anhydrase 5B, mitochondrial0202
toxin B0001
Chain A, 2-oxoglutarate Oxygenase8008
Chain A, ATP-DEPENDENT DNA HELICASE Q13003
acetylcholinesterase120012
dopamine D1 receptor3003
15-lipoxygenase, partial7007
pregnane X receptor4004
phosphopantetheinyl transferase130013
NFKB1 protein, partial3003
Thrombopoietin3003
AR protein320032
regulator of G-protein signaling 48008
glucocorticoid receptor [Homo sapiens]240024
farnesoid X nuclear receptor150015
vitamin D (1,25- dihydroxyvitamin D3) receptor170017
arylsulfatase A130013
euchromatic histone-lysine N-methyltransferase 2200020
Bloom syndrome protein isoform 1100010
D(1A) dopamine receptor3003
thyroid hormone receptor beta isoform a9009
heat shock protein beta-1110011
survival motor neuron protein isoform d140014
muscarinic acetylcholine receptor M17007
Histone deacetylase 30303
Histone deacetylase 40202
Histone deacetylase 10303
Histone deacetylase 70202
Histone deacetylase 20303
Polyamine deacetylase HDAC100101
Histone deacetylase 11 0202
Ataxin-2180018
Histone deacetylase 80202
Histone deacetylase 60202
Histone deacetylase 90101
Histone deacetylase 50202
ATP-dependent phosphofructokinase6006
potassium voltage-gated channel subfamily H member 2 isoform d6006
Phosphoribosyl pyrophosphate synthase-associated protein 20102
Adenylate kinase isoenzyme 10002
Adenylate kinase 2, mitochondrial0046
Adenosine deaminase 0103
Capsid protein 0145
Solute carrier family 22 member 60206
Solute carrier family 22 member 80104
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE170017
Chain A, MTA/SAH nucleosidase0101
Chain A, Ribosome-inactivating protein alpha-trichosanthin0011
Chain A, Ricin A chain0011
Chain A, Ribosome-inactivating protein 30011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
cytochrome P450 family 3 subfamily A polypeptide 4130013
pregnane X nuclear receptor210021
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a220022
nuclear factor erythroid 2-related factor 2 isoform 2130013
tumor susceptibility gene 101 protein2002
lamin isoform A-delta10210021
Cyclin-dependent kinase 10145
Heat shock protein HSP 90-beta0101
Xanthine dehydrogenase/oxidase0101
TAR DNA-binding protein 437007
Protein mono-ADP-ribosyltransferase PARP150101
Leucine-rich repeat serine/threonine-protein kinase 20202
ATPase family AAA domain-containing protein 5140014
Chain A, Membrane lipoprotein tmpC0011
Chain A, Membrane lipoprotein tmpC0011
Chain A, Membrane lipoprotein tmpC0011
Chain A, Structure of PAE2307 in complex with adenosine0011
Chain B, Structure of PAE2307 in complex with adenosine0011
Chain A, ADENOSINE RECEPTOR A2A0101
Chain A, ADENOSINE RECEPTOR A2A0101
Chain A, tRNA (guanine-N(1)-)-methyltransferase0011
Chain A, Uncharacterized protein MJ08830011
signal transducer and activator of transcription 6, interleukin-4 induced1001
NPYLR7B0011
IDH1120012
Histone H2A.x9009
glycogen synthase kinase-3 beta isoform 10022
mitogen-activated protein kinase 18008
nuclear receptor ROR-gamma isoform 1140014
high affinity choline transporter 1 isoform a0101
Sodium/nucleoside cotransporter 10202
Calcium dependent protein kinase0101
Mitogen-activated protein kinase kinase kinase 70011
Sodium/nucleoside cotransporter 20202
Rap guanine nucleotide exchange factor 33003
Purine nucleoside phosphorylase0303
Epidermal growth factor receptor0459
Phosphoglycerate kinase 1 0101
Adenosine deaminase0001
Avidin0011
Adenosine deaminase0001
Glyceraldehyde-3-phosphate dehydrogenase0202
Receptor tyrosine-protein kinase erbB-20314
Insulin receptor0045
Phosphoglycerate kinase 20101
Heat shock protein HSP 90-alpha0123
Platelet-derived growth factor receptor beta0146
Adenosine receptor A306310
Heat shock 70 kDa protein 1A 0101
Heat shock cognate 71 kDa protein0011
Fibroblast growth factor receptor 10045
Inosine-5'-monophosphate dehydrogenase 20347
Endoplasmin0112
Inosine-5'-monophosphate dehydrogenase 1 0303
Fibroblast growth factor receptor 20001
Fibroblast growth factor receptor 40001
Fibroblast growth factor receptor 30001
Streptavidin0011
Adenosylhomocysteinase0003
Adenosine receptor A10213
Adenosine receptor A30101
Adenosine receptor A2a0539
Adenosine receptor A2b0012
Adenosine receptor A2b0112
Adenylate kinase 2, mitochondrial0101
Adenosine receptor A10528
Adenosine receptor A2a0112
Adenylate kinase isoenzyme 1 0101
Phosphatidylinositol 4-kinase alpha0304
Adenosine receptor A10011
Adenosine kinase0045
Equilibrative nucleoside transporter 20202
Phosphatidylinositol 4-kinase type 2-beta0304
Histone-lysine N-methyltransferase, H3 lysine-79 specific0101
Equilibrative nucleoside transporter 10303
Phosphatidylinositol 4-kinase type 2-alpha0304
Solute carrier family 28 member 30202
Adenosine kinase0102
Phosphatidylinositol 4-kinase beta0304
5-methylthioadenosine/S-adenosylhomocysteine deaminase0001
Adenosine transporter 10001
thyroid stimulating hormone receptor9009
Botulinum neurotoxin type A 0101
Neutrophil cytosol factor 10101
Nitric oxide synthase, endothelial0101
Nitric oxide synthase, brain0101
Nitric oxide synthase, brain 0101
Nitric oxide synthase, inducible0101
Kappa-type opioid receptor0011
Mu-type opioid receptor0011
Tyrosine-protein kinase 0011
Chain A, TYROSYL-DNA PHOSPHODIESTERASE100010
Chain A, Ferritin light chain100010
interleukin 86006
SMAD family member 29009
Fumarate hydratase8008
SMAD family member 39009
GLI family zinc finger 3200020
thioredoxin glutathione reductase6006
G100010
polyprotein8008
P532002
peroxisome proliferator-activated receptor delta170017
activating transcription factor 6120012
v-jun sarcoma virus 17 oncogene homolog (avian)140014
peripheral myelin protein 22 isoform 15005
hemoglobin subunit beta1001
cellular tumor antigen p53 isoform a5005
nuclear factor erythroid 2-related factor 2 isoform 1210021
M-phase phosphoprotein 85005
muscleblind-like protein 1 isoform 16006
Interferon beta180018
HLA class I histocompatibility antigen, B alpha chain 100010
Cellular tumor antigen p53180018
Inositol hexakisphosphate kinase 1100010
Protein-arginine deiminase type-40404
cytochrome P450 2C9, partial100010
PPM1D protein110011
Bone morphogenetic protein receptor type-1B0044
Membrane-associated progesterone receptor component 10011
Serine/threonine-protein kinase PLK40044
ATP-dependent RNA helicase DDX3X0044
Pyridoxal kinase0044
Citron Rho-interacting kinase0044
Serine/threonine-protein kinase Chk10044
Aurora kinase A0044
Cyclin-G-associated kinase0145
Ephrin type-B receptor 60044
Peroxisomal acyl-coenzyme A oxidase 30044
Receptor-interacting serine/threonine-protein kinase 20044
Dynamin-like 120 kDa protein, mitochondrial0044
Tyrosine-protein kinase JAK20315
Eukaryotic translation initiation factor 5B0033
Rho-associated protein kinase 20044
Serine/threonine-protein kinase ULK10044
Serine/threonine-protein kinase/endoribonuclease IRE10044
Ribosomal protein S6 kinase alpha-50044
U5 small nuclear ribonucleoprotein 200 kDa helicase0044
Ribosomal protein S6 kinase alpha-40044
Serine/threonine-protein kinase 160044
Serine/threonine-protein kinase 100044
Serine/threonine-protein kinase D30156
Structural maintenance of chromosomes protein 20044
Mitogen-activated protein kinase kinase kinase 60044
Mitogen-activated protein kinase kinase kinase kinase 40044
Serine/threonine-protein kinase LATS10044
Serine/threonine-protein kinase PAK 40044
Tyrosine-protein kinase ABL10056
Guanine nucleotide-binding protein G(i) subunit alpha-20033
ADP/ATP translocase 20044
Protein kinase C beta type0257
Tyrosine-protein kinase Lck0246
Tyrosine-protein kinase Fyn0246
Glycogen phosphorylase, liver form0044
Tyrosine-protein kinase Fes/Fps0044
Adenine phosphoribosyltransferase0044
Tyrosine-protein kinase Yes0145
Tyrosine-protein kinase Lyn0145
Proto-oncogene tyrosine-protein kinase receptor Ret0145
Insulin-like growth factor 1 receptor0044
Signal recognition particle receptor subunit alpha0044
Cytochrome c1, heme protein, mitochondrial0044
Hepatocyte growth factor receptor0044
Tyrosine-protein kinase HCK0145
Serine/threonine-protein kinase A-Raf0044
Glycogen phosphorylase, brain form0044
Breakpoint cluster region protein0045
Serine/threonine-protein kinase pim-10044
DNA topoisomerase 2-alpha0044
Cyclin-dependent kinase 40044
ADP/ATP translocase 30044
Proto-oncogene tyrosine-protein kinase Src0145
cAMP-dependent protein kinase type II-alpha regulatory subunit0044
Serine/threonine-protein kinase B-raf0044
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform0044
Ribosyldihydronicotinamide dehydrogenase [quinone]0044
Tyrosine-protein kinase Fer0044
Protein kinase C alpha type0257
cAMP-dependent protein kinase catalytic subunit alpha0044
General transcription and DNA repair factor IIH helicase subunit XPD0044
Casein kinase II subunit alpha'0044
Ras-related protein Rab-6A0044
Ephrin type-A receptor 10044
Multifunctional protein ADE20044
cAMP-dependent protein kinase catalytic subunit gamma0033
cAMP-dependent protein kinase catalytic subunit beta0044
Ferrochelatase, mitochondrial0044
Ribosomal protein S6 kinase beta-10044
Tyrosine-protein kinase JAK10348
Beta-adrenergic receptor kinase 10044
Probable ATP-dependent RNA helicase DDX60044
Mitogen-activated protein kinase 3 0044
MAP/microtubule affinity-regulating kinase 30044
Deoxycytidine kinase0046
Mitogen-activated protein kinase 10044
Ephrin type-A receptor 20145
Ephrin type-B receptor 20044
Non-receptor tyrosine-protein kinase TYK20146
UMP-CMP kinase 0033
Phosphatidylethanolamine-binding protein 10044
Wee1-like protein kinase0044
Heme oxygenase 20044
S-adenosylmethionine synthase isoform type-20044
DnaJ homolog subfamily A member 10044
RAC-alpha serine/threonine-protein kinase0044
RAC-beta serine/threonine-protein kinase0044
DNA replication licensing factor MCM40044
Myosin-100044
Dual specificity mitogen-activated protein kinase kinase 20145
Receptor-type tyrosine-protein kinase FLT30246
Bone morphogenetic protein receptor type-1A0044
Activin receptor type-1B0044
TGF-beta receptor type-10044
Serine/threonine-protein kinase receptor R30022
TGF-beta receptor type-20044
Electron transfer flavoprotein subunit beta0033
Tyrosine-protein kinase CSK0145
Glycine--tRNA ligase0044
Protein kinase C iota type0156
Exosome RNA helicase MTR40044
Tyrosine-protein kinase Tec0145
Tyrosine-protein kinase ABL20044
Tyrosine-protein kinase FRK0145
G protein-coupled receptor kinase 60044
Tyrosine-protein kinase SYK0145
26S proteasome regulatory subunit 6B0044
Mitogen-activated protein kinase 80044
Mitogen-activated protein kinase 90044
Dual specificity mitogen-activated protein kinase kinase 30044
Casein kinase I isoform alpha0033
Casein kinase I isoform delta0044
MAP kinase-activated protein kinase 20044
Elongation factor Tu, mitochondrial0044
Cysteine--tRNA ligase, cytoplasmic0033
Casein kinase I isoform epsilon0044
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial0044
Dual specificity protein kinase CLK10044
Dual specificity protein kinase CLK20044
Dual specificity protein kinase CLK30033
Glycogen synthase kinase-3 alpha0044
Glycogen synthase kinase-3 beta0044
Cyclin-dependent kinase 70044
Cyclin-dependent kinase 90044
Ras-related protein Rab-27A0044
Interleukin-1 receptor-associated kinase 10044
Ribosomal protein S6 kinase alpha-30044
Serine/threonine-protein kinase Nek20044
Serine/threonine-protein kinase Nek30044
Tyrosine-protein kinase JAK30214
Dual specificity mitogen-activated protein kinase kinase 60044
LIM domain kinase 10044
LIM domain kinase 20044
Mitogen-activated protein kinase 100044
Tyrosine--tRNA ligase, cytoplasmic0044
5'-AMP-activated protein kinase subunit gamma-10045
Ephrin type-B receptor 30044
Ephrin type-A receptor 50044
Ephrin type-B receptor 40044
Ephrin type-A receptor 40044
Ras-related protein Rab-100044
Actin-related protein 30044
Actin-related protein 20044
GTP-binding nuclear protein Ran0044
Casein kinase I isoform gamma-20044
Cyclin-dependent kinase 30033
Cyclin-dependent kinase 60044
Cyclin-dependent-like kinase 5 0044
Cyclin-dependent kinase 160044
Cyclin-dependent kinase 170044
ATP-dependent 6-phosphofructokinase, platelet type0044
Dual specificity mitogen-activated protein kinase kinase 10044
DNA topoisomerase 2-beta0044
Protein kinase C theta type0156
Activin receptor type-10044
Macrophage-stimulating protein receptor0044
Focal adhesion kinase 10044
Protein kinase C delta type0257
Tyrosine-protein kinase BTK0257
Activated CDC42 kinase 10044
Epithelial discoidin domain-containing receptor 10044
Mitogen-activated protein kinase kinase kinase kinase 20044
Serine/threonine-protein kinase 40044
5'-AMP-activated protein kinase catalytic subunit alpha-10045
Dual specificity mitogen-activated protein kinase kinase 50044
Mitogen-activated protein kinase 70044
Serine/threonine-protein kinase PAK 20044
Serine/threonine-protein kinase 30044
Mitogen-activated protein kinase kinase kinase 10044
Integrin-linked protein kinase0044
Rho-associated protein kinase 10044
Non-receptor tyrosine-protein kinase TNK10044
Serine/threonine-protein kinase ATR0011
Calcium/calmodulin-dependent protein kinase type II subunit gamma0044
Calcium/calmodulin-dependent protein kinase type II subunit delta0044
Dual specificity tyrosine-phosphorylation-regulated kinase 1A0044
Activin receptor type-2B0044
Bone morphogenetic protein receptor type-20044
Protein-tyrosine kinase 60145
cGMP-dependent protein kinase 1 0044
Cyclin-dependent kinase 130044
Inhibitor of nuclear factor kappa-B kinase subunit epsilon0044
Protein-tyrosine kinase 2-beta0044
Maternal embryonic leucine zipper kinase0044
Structural maintenance of chromosomes protein 1A0044
Chromodomain-helicase-DNA-binding protein 40044
Peroxisomal acyl-coenzyme A oxidase 10033
Ephrin type-A receptor 70033
Delta(24)-sterol reductase0044
Ribosomal protein S6 kinase alpha-10145
Dual specificity testis-specific protein kinase 10033
Myosin light chain kinase, smooth muscle0044
Serine/threonine-protein kinase STK110044
Serine/threonine-protein kinase N10044
Serine/threonine-protein kinase N20044
Calcium/calmodulin-dependent protein kinase type IV0044
Mitogen-activated protein kinase kinase kinase 110044
MAP kinase-activated protein kinase 30022
Discoidin domain-containing receptor 20044
AP2-associated protein kinase 10145
Myosin light chain kinase 30044
Uncharacterized aarF domain-containing protein kinase 50022
Putative heat shock protein HSP 90-beta 20044
Rab-like protein 30022
Serine/threonine-protein kinase MRCK alpha0044
Serine/threonine-protein kinase MRCK gamma0044
Acyl-CoA dehydrogenase family member 100044
Serine/threonine-protein kinase ULK30044
Uncharacterized protein FLJ452520044
Acyl-CoA dehydrogenase family member 110044
Serine/threonine-protein kinase/endoribonuclease IRE20044
Serine/threonine-protein kinase MARK20044
ATP-dependent RNA helicase DHX300044
Serine/threonine-protein kinase TAO10044
STE20-related kinase adapter protein alpha0044
Myosin-140044
AarF domain-containing protein kinase 10044
ATP-dependent RNA helicase DDX420033
Mitogen-activated protein kinase kinase kinase kinase 30044
MAP kinase-activated protein kinase 50033
Eukaryotic peptide chain release factor GTP-binding subunit ERF3B0022
Misshapen-like kinase 10033
Atypical kinase COQ8A, mitochondrial0044
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma0044
Mitogen-activated protein kinase 150044
Serine/threonine-protein kinase Nek90044
ATP-dependent RNA helicase DDX10044
Mitogen-activated protein kinase kinase kinase kinase 10044
Aurora kinase B0044
Calcium/calmodulin-dependent protein kinase type 1G0033
Serine/threonine-protein kinase Nek10044
PAS domain-containing serine/threonine-protein kinase0044
Calcium/calmodulin-dependent protein kinase kinase 20044
EKC/KEOPS complex subunit TP53RK0044
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase0044
Mitogen-activated protein kinase kinase kinase 50044
Mitogen-activated protein kinase kinase kinase 30044
Eukaryotic translation initiation factor 2-alpha kinase 10044
Nucleolar GTP-binding protein 10044
Serine/threonine-protein kinase D20044
NUAK family SNF1-like kinase 20033
RNA cytidine acetyltransferase0044
Serine/threonine-protein kinase SIK20044
STE20-like serine/threonine-protein kinase 0044
Serine/threonine-protein kinase TAO30044
dCTP pyrophosphatase 10044
Dual specificity protein kinase CLK40044
Casein kinase I isoform gamma-10044
Serine/threonine-protein kinase PAK 60022
Phenylalanine--tRNA ligase beta subunit0044
Isoleucine--tRNA ligase, mitochondrial0022
BMP-2-inducible protein kinase0044
Obg-like ATPase 10044
Midasin0044
Interleukin-1 receptor-associated kinase 40044
Mitogen-activated protein kinase kinase kinase 200044
Cyclin-dependent kinase 120044
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 130033
Serine/threonine-protein kinase 260044
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial0044
Serine/threonine-protein kinase NLK0044
5'-AMP-activated protein kinase subunit gamma-20045
Serine/threonine-protein kinase TBK10044
Septin-90044
Ribosomal protein S6 kinase alpha-60044
TRAF2 and NCK-interacting protein kinase0044
Serine/threonine-protein kinase TAO20044
Long-chain-fatty-acid--CoA ligase 50022
Serine/threonine-protein kinase ICK0033
RAC-gamma serine/threonine-protein kinase0044
Serine/threonine-protein kinase 38-like0011
Serine/threonine-protein kinase SIK30044
Mitogen-activated protein kinase kinase kinase 20044
Thyroid hormone receptor-associated protein 30044
Mitogen-activated protein kinase kinase kinase kinase 50044
Receptor-interacting serine/threonine-protein kinase 30044
Serine/threonine-protein kinase MRCK beta0044
Interleukin-1 receptor-associated kinase 30044
Serine/threonine-protein kinase 240033
Casein kinase I isoform gamma-30044
Mitogen-activated protein kinase kinase kinase 40044
Proteasome subunit beta type-110101
Calpain-90101
Proteasome subunit alpha type-70101
Cathepsin B0101
Replicase polyprotein 1ab0235
Replicase polyprotein 1ab0538
Aromatase0202
Indoleamine 2,3-dioxygenase 10101
Calpain-2 catalytic subunit0101
Proteasome subunit beta type-10202
Proteasome subunit alpha type-10101
Proteasome subunit alpha type-20101
Proteasome subunit alpha type-30101
Proteasome subunit alpha type-40101
NF-kappa-B inhibitor alpha0011
Proteasome subunit beta type-80101
Proteasome subunit beta type-90101
Proteasome subunit alpha type-50101
Proteasome subunit beta type-40101
Proteasome subunit beta type-60101
Proteasome subunit beta type-50202
Proteasome subunit beta type-100101
Cathepsin K0101
Proteasome subunit beta type-30101
Proteasome subunit beta type-20202
Proteasome subunit alpha type-60101
Proteasome subunit alpha-type 80101
Proteasome subunit beta type-70101
Gamma-secretase subunit PEN-20101
Chain A, Putative fructose-1,6-bisphosphate aldolase3003
Chain A, HADH2 protein7007
Chain B, HADH2 protein7007
Chain A, Cruzipain6006
caspase-1 isoform alpha precursor3003
Caspase-73003
Inositol monophosphatase 13003
Solute carrier organic anion transporter family member 1B307011
Solute carrier organic anion transporter family member 1B109012
5-hydroxytryptamine receptor 1A0719
Spike glycoprotein80311
Potassium voltage-gated channel subfamily H member 2010010
Nonstructural protein 5A 0112
estrogen receptor 2 (ER beta)130013
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a8008
PAX80002
67.9K protein110011
NPC intracellular cholesterol transporter 1 precursor5005
major prion protein preproprotein Prp precursor0101
nuclear receptor subfamily 0 group B member 10101
ras-related protein Rab-9A5005
steroidogenic factor 10101
Chain A, Beta-lactamase8008
Vpr2002
Albumin0011
Major prion protein0011
Sodium channel protein type 1 subunit alpha0101
Sodium channel protein type 2 subunit alpha0101
Sodium channel protein type 3 subunit alpha0101
UDP-glucuronosyltransferase 2B70002
Cytochrome P450 2B60528
Sodium channel protein type 4 subunit alpha0102
Sodium channel protein type 9 subunit alpha0202
Frizzled-80011
P2X purinoceptor 40101
Lactoperoxidase0101
hypoxia-inducible factor 1 alpha subunit8008
caspase 7, apoptosis-related cysteine protease6006
caspase-36006
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)2002
thyrotropin-releasing hormone receptor2002
Caspase-20011
nonstructural protein 14004
parathyroid hormone/parathyroid hormone-related peptide receptor precursor5005
Cytochrome P450 2C80506
Liver carboxylesterase 10002
Sodium-dependent serotonin transporter0808
Cytochrome P450 2C19010011
Rap guanine nucleotide exchange factor 41001
P2Y purinoceptor 120101
Chain A, CHIMERA OF IG KAPPA CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION0011
Chain B, CHIMERA OF IG GAMMA-1 CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION0011
Chain H, Fab M82G2, Heavy chain0011
Chain L, Fab M82G2, Light chain0011
Chain H, Fab M82g2, Heavy Chain0011
Chain L, Fab M82g2, Light Chain0011
Gamma-aminobutyric acid receptor subunit pi0202
Gamma-aminobutyric acid receptor subunit delta0202
Amyloid-beta precursor protein1203
Fatty acid-binding protein, heart0303
Muscarinic acetylcholine receptor M20101
Muscarinic acetylcholine receptor M10101
5-hydroxytryptamine receptor 2C0304
Tryptophan 5-hydroxylase 10101
5-hydroxytryptamine receptor 2A0303
Gamma-aminobutyric acid receptor subunit alpha-10213
Gamma-aminobutyric acid receptor subunit beta-10202
Gamma-aminobutyric acid receptor subunit gamma-20213
D0101
Alpha-2B adrenergic receptor0112
Alpha-2C adrenergic receptor0112
Alpha-2A adrenergic receptor0112
Sodium-dependent noradrenaline transporter 0617
Sodium-dependent dopamine transporter0303
cAMP-specific 3',5'-cyclic phosphodiesterase 4A0202
Gamma-aminobutyric acid receptor subunit beta-30213
5-hydroxytryptamine receptor 1B0505
5-hydroxytryptamine receptor 1D0101
5-hydroxytryptamine receptor 1F0101
5-hydroxytryptamine receptor 2B0202
5-hydroxytryptamine receptor 60101
Gamma-aminobutyric acid receptor subunit alpha-50213
Sodium-dependent serotonin transporter0304
5-hydroxytryptamine receptor 7 0101
Gamma-aminobutyric acid receptor subunit alpha-30213
5-hydroxytryptamine receptor 5A0101
5-hydroxytryptamine receptor 5B0101
Glutamate receptor ionotropic, NMDA 1 0101
5-hydroxytryptamine receptor 3A0101
Lysosomal Pro-X carboxypeptidase0101
Gamma-aminobutyric acid receptor subunit alpha-20202
Gamma-aminobutyric acid receptor subunit beta-20202
Gamma-aminobutyric acid receptor subunit alpha-40202
D(2) dopamine receptor0101
Gamma-aminobutyric acid receptor subunit epsilon0202
Glutamate receptor ionotropic, NMDA 2A 0101
Glutamate receptor ionotropic, NMDA 2B0101
Glutamate receptor ionotropic, NMDA 2C0101
Sodium-dependent dopamine transporter 0606
cAMP-specific 3',5'-cyclic phosphodiesterase 4B0202
cAMP-specific 3',5'-cyclic phosphodiesterase 4D0202
Leukotriene B4 receptor 10101
Gamma-aminobutyric acid receptor subunit alpha-60202
Sodium-dependent dopamine transporter0202
Glutamate receptor ionotropic, NMDA 2D0101
5-hydroxytryptamine receptor 4 0101
Gamma-aminobutyric acid receptor subunit gamma-10202
Glutamate receptor ionotropic, NMDA 3B0101
Sigma non-opioid intracellular receptor 10808
Gamma-aminobutyric acid receptor subunit gamma-30202
5-hydroxytryptamine receptor 3B0101
Leukotriene B4 receptor 20101
Glutamate receptor ionotropic, NMDA 3A0101
Gamma-aminobutyric acid receptor subunit theta0202
Transporter0202
Metabotropic glutamate receptor 60011
Glutamate transporter homolog0011
Excitatory amino acid transporter 10101
Metabotropic glutamate receptor 10011
Metabotropic glutamate receptor 20011
6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase 0101
bromodomain adjacent to zinc finger domain 2B6006
cytochrome P450 2C9 precursor4004
Myeloperoxidase0202
Dihydrofolate reductase0303
Histamine H2 receptor7007
5-hydroxytryptamine receptor 60516
Thymidine kinase 2 0101
Probable deoxycytidylate deaminase0001
Cytidine deaminase0002
AAA family ATPase 0002
Reverse transcriptase/RNaseH 0136
endonuclease IV4004
glucocerebrosidase3003
DNA polymerase beta5005
neuropeptide S receptor isoform A4004
Acetylcholine-binding protein0101
Soluble acetylcholine receptor0101
STAT3, partial0101
alpha-galactosidase6006
tumor necrosis factor1001
signal transducer and activator of transcription 1-alpha/beta isoform alpha0101
lethal factor (plasmid)4004
Solute carrier organic anion transporter family member 1A40406
Sodium/potassium-transporting ATPase subunit alpha-1 0303
Sodium/potassium-transporting ATPase subunit beta-10303
Integrin beta-34004
Sodium/potassium-transporting ATPase subunit alpha-20101
Sodium/potassium-transporting ATPase subunit alpha-3 0101
ATP-dependent translocase ABCB10202
Sodium/potassium-transporting ATPase subunit beta-1 0101
ATP-dependent translocase ABCB108110
Integrin alpha-IIb4004
Sodium/potassium-transporting ATPase subunit alpha-30202
Sodium/potassium-transporting ATPase subunit beta-20202
ATP-dependent translocase ABCB10202
Sodium/potassium-transporting ATPase subunit alpha-20303
Sodium/potassium-transporting ATPase subunit alpha-10101
Sodium/potassium-transporting ATPase subunit beta-30202
Sodium/potassium-transporting ATPase subunit gamma0202
Sodium/potassium-transporting ATPase subunit alpha-40202
Sodium/potassium-transporting ATPase subunit alpha-40101
Solute carrier organic anion transporter family member 4C10001
Solute carrier organic anion transporter family member 4C10001
Solute carrier organic anion transporter family member 1A40001
Kelch-like ECH-associated protein 10011
Nuclear factor erythroid 2-related factor 20011
Cell division cycle 7-related protein kinase0033
Mitotic checkpoint serine/threonine-protein kinase BUB10033
High affinity nerve growth factor receptor0033
Tyrosine-protein kinase Fgr0123
Potassium voltage-gated channel subfamily E member 10101
Dual specificity protein kinase TTK0033
Serine/threonine-protein kinase mTOR0325
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha1034
Choline-phosphate cytidylyltransferase A0033
Potassium voltage-gated channel subfamily KQT member 10101
Serine/threonine-protein kinase PLK10033
Sodium channel protein type 5 subunit alpha0202
Serine/threonine-protein kinase N30022
Regulatory-associated protein of mTOR0202
Serine/threonine-protein kinase Nek70022
MAP/microtubule affinity-regulating kinase 40033
Dual specificity testis-specific protein kinase 20022
Target of rapamycin complex subunit LST80202
Potassium voltage-gated channel subfamily D member 30101
Sphingosine 1-phosphate receptor 10011
RCG53912, isoform CRA_a 0001
Sphingosine kinase 1 0001
Sphingosine kinase 20304
Sphingosine kinase 10203
cytochrome P450 2D6 isoform 16006
cytochrome P450 2C19 precursor5005
Gamma-aminobutyric acid receptor subunit alpha-10202
Gamma-aminobutyric acid receptor subunit beta-10202
Neuronal acetylcholine receptor subunit alpha-41102
Gamma-aminobutyric acid receptor subunit alpha-20202
Gamma-aminobutyric acid receptor subunit alpha-30202
Neuronal acetylcholine receptor subunit beta-21102
Gamma-aminobutyric acid receptor subunit alpha-40202
Gamma-aminobutyric acid receptor subunit gamma-20202
Neuronal acetylcholine receptor subunit alpha-70101
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)5005
hexokinase-4 isoform 11001
atrial natriuretic peptide receptor 1 precursor2002
glucokinase regulatory protein1001
eyes absent homolog 2 isoform a1001
DNA dC->dU-editing enzyme APOBEC-3G isoform 11001
Polyunsaturated fatty acid lipoxygenase ALOX15B5005
Potassium voltage-gated channel subfamily KQT member 30012
Potassium voltage-gated channel subfamily KQT member 20012
Serine hydroxymethyltransferase, mitochondrial0101
Potassium voltage-gated channel subfamily KQT member 40001
Single-stranded DNA cytosine deaminase1001
Potassium voltage-gated channel subfamily KQT member 50001
phosphoglycerate kinase2002
Thymidine kinase 0101
ClpP2002
Solute carrier family 22 member 1 0203
POU domain, class 2, transcription factor 20001
Transitional endoplasmic reticulum ATPase0101
Purine nucleoside phosphorylase0011
Chain A, DEOXYNUCLEOSIDE KINASE0101
Spike glycoprotein0033
Replicase polyprotein 1ab0134
Transmembrane protease serine 20033
Procathepsin L0033
Replicase polyprotein 1a0033
Replicase polyprotein 1ab0033
Angiotensin-converting enzyme 2 0033
Solute carrier organic anion transporter family member 1A50002
Sodium/bile acid cotransporter0103
Solute carrier organic anion transporter family member 1A10204
G-protein coupled bile acid receptor 10033
Multidrug resistance associated protein0205
Bile salt export pump0002
Hypoxanthine-guanine phosphoribosyltransferase0001
Ricin0101
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase0011
Purine nucleoside phosphorylase 0012
Shiga toxin subunit A0101
Guanine deaminase0001
Chain A, Uracil Phosphoribosyltransferase0011
Chain B, Uracil Phosphoribosyltransferase0011
Chain C, Uracil Phosphoribosyltransferase0011
2-dehydropantoate 2-reductase0011
Ras-related protein Rab-7a0011
4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase 90202
N(G),N(G)-dimethylarginine dimethylaminohydrolase 10202
Luciferase9009
histone deacetylase 9 isoform 33003
3-oxoacyl-[acyl-carrier-protein] synthase 3 0101
histone acetyltransferase KAT2A isoform 16006
N-glycosylase/DNA lyase0101
Polyphenol oxidase 20203
Formamidopyrimidine-DNA glycosylase0101
DNA gyrase subunit A0101
DNA gyrase subunit B0101
Cytochrome P450 2A60101
Macrophage migration inhibitory factor0101
Endonuclease III-like protein 10101
DNA gyrase subunit B0202
DNA gyrase subunit A0202
Enoyl-[acyl-carrier-protein] reductase [NADH]0204
Pantothenate synthetase0101
Isocitrate lyase0101
Putative FAD-containing monooxygenase MymA0101
Dihydrofolate reductase0202
Endonuclease 8-like 10101
Hsf1 protein0011
Voltage-dependent L-type calcium channel subunit alpha-1F0202
Albumin0136
Voltage-dependent L-type calcium channel subunit alpha-1D 0202
Voltage-dependent L-type calcium channel subunit alpha-1S0202
Voltage-dependent L-type calcium channel subunit alpha-1C0303
apical membrane antigen 1, AMA13003
cytochrome P450 2D67007
Parkin2002
nuclear receptor subfamily 1, group I, member 25005
lysosomal alpha-glucosidase preproprotein1001
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 15005
phosphoethanolamine/phosphocholine phosphatase isoform 10101
atrial natriuretic peptide receptor 2 precursor1001
Microtubule-associated protein tau0213
Indoleamine 2,3-dioxygenase 10101
Alpha-synuclein6107
Fatty acid synthase0202
WD repeat-containing protein 50101
Histone-lysine N-methyltransferase 2A0101
Cytosolic endo-beta-N-acetylglucosaminidase0101
Indoleamine 2,3-dioxygenase 20101
Broad substrate specificity ATP-binding cassette transporter ABCG20506
glp-1 receptor, partial5005
matrix metalloproteinase 1, partial0011
pyruvate kinase1001
huntingtin isoform 22002
Dihydroorotate dehydrogenase (quinone), mitochondrial0101
Aldo-keto reductase family 1 member B10404
Amine oxidase [flavin-containing] A0202
Endothelin receptor type B1001
Endothelin-1 receptor1001
Dihydroorotate dehydrogenase (quinone), mitochondrial0101
Dihydroorotate dehydrogenase (quinone), mitochondrial0101
Cereblon isoform 40404
Bromodomain-containing protein 40101
DNA-binding protein Ikaros0014
DNA damage-binding protein 10213
Protein cereblon05210
Zinc finger protein Aiolos0011
Chain A, AMINOPEPTIDASE0101
Chain A, AMINOPEPTIDASE0101
Chain A, Leucine Aminopeptidase0101
Alkaline phosphatase, tissue-nonspecific isozyme0101
Intestinal-type alkaline phosphatase0101
Large neutral amino acids transporter small subunit 10202
Proton-coupled amino acid transporter 10102
Phospholipase A-2-activating protein0101
Free fatty acid receptor 10011
Prostaglandin G/H synthase 1 0101
Sterol O-acyltransferase 10101
Trypsin0101
Seed linoleate 13S-lipoxygenase-10101
Coagulation factor VII0101
Tissue factor0101
Tyrosine-protein phosphatase non-receptor type 70101
Sterol O-acyltransferase 10101
Aldo-keto reductase family 1 member C30101
Nuclear receptor subfamily 4 group A member 20011
Dual specificity protein phosphatase 30101
Prostaglandin G/H synthase 20202
Peroxisome proliferator-activated receptor alpha1001
Free fatty acid receptor 40011
Chain B, DIHYDROFOLATE REDUCTASE0011
Chain B, DIHYDROFOLATE REDUCTASE0011
Chain B, DIHYDROFOLATE REDUCTASE0011
Thymidylate synthase 0101
Thymidylate synthase 0101
polyunsaturated fatty acid lipoxygenase ALOX121001
transcriptional regulator ERG isoform 32002
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]0101
transactivating tegument protein VP16 [Human herpesvirus 1]0101
nuclear receptor coactivator 3 isoform a0101
Toll-like receptor 40101
Fatty-acid amide hydrolase 10101
ATP-binding cassette sub-family C member 30103
Dihydrofolate reductase0203
Dihydrofolate reductase0203
Dihydrofolate reductase 0101
Dihydrofolate reductase0101
Dihydrofolate reductase0101
Dihydrofolate reductase0203
Thymidylate synthase0101
Thymidylate synthase0202
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Thymidylate synthase0202
High mobility group protein B10022
Dihydrofolate reductase0101
Thymidylate synthase0101
Dihydrofolate reductase0224
Glucose-6-phosphate 1-dehydrogenase0101
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Folate receptor beta0101
Cytochrome P450 11B1, mitochondrial 0101
Folate receptor alpha0101
Histidine decarboxylase0101
Trifunctional purine biosynthetic protein adenosine-30101
Bifunctional purine biosynthesis protein ATIC0202
Multidrug resistance-associated protein 1 0001
Delta-type opioid receptor0101
Mu-type opioid receptor0303
Kappa-type opioid receptor0101
Reduced folate transporter0202
Folylpolyglutamate synthase, mitochondrial0103
6-phosphogluconate dehydrogenase, decarboxylating0101
Solute carrier organic anion transporter family member 1A30103
Pteridine reductase 10101
Folylpolyglutamate synthase, mitochondrial0103
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Canalicular multispecific organic anion transporter 10102
Trifunctional purine biosynthetic protein adenosine-30101
Solute carrier family 22 member 200202
Dihydrofolate reductase 0101
Solute carrier family 22 member 60202
Dihydrofolate reductase0101
ATP-binding cassette sub-family C member 110001
Proton-coupled folate transporter0101
Solute carrier family 22 member 110001
Chain E, Fibrin beta chain0101
T cell receptor, partial1001
luteinizing hormone receptor1001
integrase, partial0101
chaperonin-containing TCP-1 beta subunit homolog2002
lens epithelium-derived growth factor p750101
Caspase 6, apoptosis-related cysteine peptidase0001
TSHR protein1001
Apoptotic peptidase activating factor 10101
hypothetical protein, conserved1001
isocitrate dehydrogenase 1, partial1001
luciferase1001
serine-protein kinase ATM isoform a1001
neutrophil cytosol factor 10101
caspase-9 isoform alpha precursor0101
pyruvate kinase PKM isoform a1001
caspase-3 isoform a preproprotein0101
protein AF-9 isoform a0001
histone-lysine N-methyltransferase 2A isoform 2 precursor1001
replicative DNA helicase0001
recombinase A0011
POsterior Segregation0011
DNA repair protein RAD52 homolog isoform a0001
Glutathione reductase0101
Glutathione reductase, mitochondrial0102
Glycoprotein hormones alpha chain1001
Albumin0001
Dihydrolipoyl dehydrogenase, mitochondrial0102
Alpha-1B adrenergic receptor0516
Alpha-1D adrenergic receptor0314
Cruzipain0101
Alpha-1A adrenergic receptor0516
Thioredoxin reductase 1, cytoplasmic0102
Dihydrolipoyl dehydrogenase 0102
Zinc finger protein mex-50011
Nuclear receptor subfamily 1 group I member 20055
Glucocorticoid receptor06314
Glycine receptor subunit alpha-10606
Androgen receptor0505
Glycine receptor subunit beta0606
Glycine receptor subunit alpha-20606
Glycine receptor subunit alpha-30606
Nuclear receptor subfamily 1 group I member 20011
Nuclear receptor corepressor 10101
Integrin beta-10101
Leukotriene A-4 hydrolase0101
Integrin alpha-40101
Nuclear receptor corepressor 20101
Chain A, Inosine-5'-Monophosphate Dehydrogenase 20101
Glutamate receptor 10101
Glutamate receptor 30101
Glutamate receptor 40101
Peroxisome proliferator-activated receptor gamma0011
Inosine-5'-monophosphate dehydrogenase0102
UDP-glucuronosyltransferase 1A70001
UDP-glucuronosyltransferase 1A100001
UDP-glucuronosyltransferase 1A80001
Acetylcholinesterase0101
Cholinesterase0202
Acetylcholinesterase0303
Cholinesterase0101
NS5 0033
Carbonic anhydrase0303
Sodium/iodide cotransporter0101
tyrosine-protein kinase Yes1001
Testosterone 17-beta-dehydrogenase 30101
Putative nucleoside diphosphate kinase0011
Solute carrier family 22 member 30202
Macrophage colony-stimulating factor 1 receptor0101
Receptor tyrosine-protein kinase erbB-30101
Nucleoside diphosphate kinase B0011
G1/S-specific cyclin-E10101
Tyrosine-protein kinase TXK0112
Tyrosine-protein kinase Blk0112
Cytoplasmic tyrosine-protein kinase BMX0213
cAMP-dependent protein kinase catalytic subunit PRKX0011
Tyrosine-protein kinase ITK/TSK0112
Tyrosine-protein kinase Mer0022
Serine/threonine-protein kinase 380011
Receptor tyrosine-protein kinase erbB-40112
Sigma intracellular receptor 20101
Nuclear receptor subfamily 4 group A member 30101
Peroxiredoxin-like 2A0101
Platelet glycoprotein VI0101
Dual specificity tyrosine-phosphorylation-regulated kinase 1B0022
luciferase0001
Fatty acid-binding protein, liver0101
Estrogen receptor0416
Progesterone receptor0304
Glucocorticoid receptor0112
Glucocorticoid receptor0011
Corticosteroid-binding globulin0101
Mineralocorticoid receptor 0213
Androgen receptor0202
Glutamine synthetase0011
Histamine H1 receptor0011
Nociceptin receptor0011
Estrogen receptor beta0415
Beta-1 adrenergic receptor 0113
Voltage-dependent L-type calcium channel subunit alpha-1C0101
5-hydroxytryptamine receptor 40404
Beta-2 adrenergic receptor0213
Muscarinic acetylcholine receptor M20314
Beta-1 adrenergic receptor0415
5-hydroxytryptamine receptor 1A0101
Alpha-2A adrenergic receptor0528
Beta-2 adrenergic receptor0203
Muscarinic acetylcholine receptor M10314
Beta-3 adrenergic receptor0415
D(2) dopamine receptor0314
Alpha-2B adrenergic receptor0416
Beta-1 adrenergic receptor0315
Alpha-2C adrenergic receptor0326
D(3) dopamine receptor0101
Muscarinic acetylcholine receptor M30314
D(1A) dopamine receptor0314
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Alpha-1D adrenergic receptor0214
Endothelin-1 receptor0112
Beta-3 adrenergic receptor0202
5-hydroxytryptamine receptor 1B0213
5-hydroxytryptamine receptor 2A0415
5-hydroxytryptamine receptor 2C0415
Neuromedin-K receptor0011
Type-1 angiotensin II receptor0112
Cholecystokinin receptor type A0112
5-hydroxytryptamine receptor 70112
Beta-1 adrenergic receptor0101
Alpha-1A adrenergic receptor0124
Alpha-1B adrenergic receptor0012
Mu-type opioid receptor0516
Vasopressin V1a receptor0314
Delta-type opioid receptor0314
Kappa-type opioid receptor0516
5-hydroxytryptamine receptor 2B0415
5-hydroxytryptamine receptor 70101
Beta-2 adrenergic receptor0101
Sodium/bile acid cotransporter0405
Beta-2 adrenergic receptor0113
Nuclear receptor subfamily 2 group E member 10022
NAD-dependent protein deacetylase sirtuin-60101
Polymerase basic protein 20011
RNA-directed RNA polymerase catalytic subunit0011
Polymerase acidic protein0022
Adenosine receptor A10101
Genome polyprotein0011
DNA-directed RNA polymerase subunit beta0101
Solute carrier organic anion transporter family member 2B1 0405
NH(3)-dependent NAD(+) synthetase0101
60 kDa heat shock protein, mitochondrial0101
Arylacetamide deacetylase0102
Caspase-10101
Solute carrier organic anion transporter family member 1A20102
10 kDa heat shock protein, mitochondrial0101
Glutathione S-transferase omega-10101
DNA-directed RNA polymerase subunit beta0101
Thiosulfate sulfurtransferase0101
Lanosterol 14-alpha demethylase0101
60 kDa chaperonin 0101
10 kDa chaperonin 0101
Chain A, HIV-1 PROTEASE0101
Chain B, HIV-1 PROTEASE0101
Chain A, POL polyprotein0101
Chain B, POL polyprotein0101
Chain A, POL polyprotein0101
Chain B, POL polyprotein0101
Chain A, Endothiapepsin0101
Chain A, Endothiapepsin0101
Solute carrier family 22 member 20101
Gag-Pol polyprotein0101
Gag-Pol polyprotein0101
Gag-Pol polyprotein0101
Gag-Pol polyprotein0101
Gag-Pol polyprotein0101
Cytochrome P450 3A50202
Substance-K receptor0404
Thromboxane-A synthase 0202
Gag-Pol polyprotein0101
Thromboxane-A synthase0001
Protease 0114
Multidrug and toxin extrusion protein 20101
Plasmepsin V 0101
Multidrug and toxin extrusion protein 10101
Protease 0213
Estrogen receptor beta0001
Inhibitor of nuclear factor kappa-B kinase subunit beta0001
5'-AMP-activated protein kinase subunit beta-20001
Stromelysin-10011
Tyrosine-protein phosphatase YopH0101
Aldo-keto reductase family 1 member B10101
Prolyl 4-hydroxylase subunit alpha-10101
Tyrosine-protein phosphatase non-receptor type 10103
Estrogen receptor0001
Cystathionine gamma-lyase0101
5'-AMP-activated protein kinase catalytic subunit alpha-20001
Xanthine dehydrogenase/oxidase0101
Carbonic anhydrase0101
Solute carrier family 22 member 70001
Nicotinate phosphoribosyltransferase0101
Ubiquitin-like domain-containing CTD phosphatase 10101
5'-AMP-activated protein kinase subunit gamma-30001
5'-AMP-activated protein kinase subunit beta-10001
Eukaryotic initiation factor 4A-I0011
Transcription factor p650101
Cyclin-dependent kinase-like 50011
Sarcoplasmic/endoplasmic reticulum calcium ATPase 10101
Eukaryotic translation initiation factor 4E0011
Peptidyl-prolyl cis-trans isomerase FKBP1A0101
Peptidyl-prolyl cis-trans isomerase FKBP1A0426
Peptidyl-prolyl cis-trans isomerase FKBP1B0022
Protein kinase C zeta type0123
Cyclin-dependent kinase 180011
Peptidyl-prolyl cis-trans isomerase FKBP50202
Programmed cell death protein 40011
Serine/threonine-protein kinase mTOR 0101
Carbonic anhydrase 0202
Carbonic anhydrase 0202
RNA-directed RNA polymerase 0012
C-X-C chemokine receptor type 5 isoform 10101
ubiquitin-conjugating enzyme E2 N0202
C-C chemokine receptor type 60101
apelin receptor0101
bcl-2-related protein A10101
streptokinase A precursor0033
Endoglycoceramidase II 0001
Protein kinase C alpha type0202
Estrogen receptor0023
Protein kinase C delta type0202
Protein kinase C epsilon type0202
Protein kinase C zeta type0202
cAMP-dependent protein kinase catalytic subunit alpha 0101
Protein kinase C gamma type0202
Protein kinase C beta type0202
Estrogen receptor beta0023
Protein kinase C eta type0202
Protein kinase C theta type0202
UDP-glucuronosyltransferase 1A40002
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform0202
Splicing factor 3B subunit 30101
Chain A, CES1 protein0101
DNA polymerase III, partial1001
Caspase-71001
interferon gamma precursor0001
caspase-31001
serine/threonine-protein kinase mTOR isoform 11001
Lysosomal acid glucosylceramidase0011
Protein kinase C gamma type0213
Muscarinic acetylcholine receptor M40202
Muscarinic acetylcholine receptor M50202
Polyunsaturated fatty acid 5-lipoxygenase0101
Steroid hormone receptor ERR10101
Transcriptional activator protein LuxR0101
Angiotensin-converting enzyme0202
D(4) dopamine receptor0202
Protein kinase C eta type0112
Histamine H2 receptor0202
Substance-P receptor0202
B2 bradykinin receptor0202
Melanocortin receptor 40202
C-8 sterol isomerase0101
Melanocortin receptor 50202
D(3) dopamine receptor0202
Melanocortin receptor 30202
D(1A) dopamine receptor1001
Estrogen-related receptor gamma0101
Phospholipase D1 0101
Protein kinase C epsilon type0213
Platelet-activating factor acetylhydrolase0101
Phospholipase D10101
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase0213
Serine/threonine-protein kinase D10112
Nuclear receptor subfamily 3 group C member 3 0202
Emopamil-binding protein-like0101
7-dehydrocholesterol reductase0112
Sodium/bile acid cotransporter0001
Ileal sodium/bile acid cotransporter0001
Ileal sodium/bile acid cotransporter0203
Ileal sodium/bile acid cotransporter0001
Solute carrier organic anion transporter family member0001
Solute carrier organic anion transporter family member 4A10001
Solute carrier organic anion transporter family member 1C10101
Solute carrier organic anion transporter family member 2B10001
Solute carrier organic anion transporter family member 1A10001
Solute carrier organic anion transporter family member 1B20001
Solute carrier family 22 member 80101
Cytochrome P450 14alpha-demethylase0011
Sterol 14-alpha demethylase0101
Carnitine O-palmitoyltransferase 1, muscle isoform0101
Luciferin 4-monooxygenase0011
Ras guanyl-releasing protein 30011
cAMP-specific 3',5'-cyclic phosphodiesterase 4C0101
ubiquitin carboxyl-terminal hydrolase 2 isoform a1001
Disintegrin and metalloproteinase domain-containing protein 171001
Urease subunit alpha0101
Urease subunit beta0101
Olfactory receptor 51E20011
Ubiquitin carboxyl-terminal hydrolase 20101
Vitamin D3 receptor0112
Bile acid receptor0011
CDGSH iron-sulfur domain-containing protein 10202
M1-family alanyl aminopeptidase0101
Chain A, Arginase 10101
twin arginine protein translocation system - TatA protein0001
30S ribosomal protein S60101
30S ribosomal protein S70101
50S ribosomal protein L150101
50S ribosomal protein L100101
50S ribosomal protein L110101
50S ribosomal protein L7/L120101
50S ribosomal protein L190101
50S ribosomal protein L10101
50S ribosomal protein L200101
50S ribosomal protein L270101
50S ribosomal protein L280101
50S ribosomal protein L290101
50S ribosomal protein L310101
50S ribosomal protein L31 type B0101
50S ribosomal protein L320101
50S ribosomal protein L330101
50S ribosomal protein L340101
50S ribosomal protein L350101
50S ribosomal protein L360101
30S ribosomal protein S100101
30S ribosomal protein S110101
30S ribosomal protein S120101
30S ribosomal protein S130101
30S ribosomal protein S160101
30S ribosomal protein S180101
30S ribosomal protein S190101
30S ribosomal protein S200101
30S ribosomal protein S20101
30S ribosomal protein S30101
30S ribosomal protein S40101
30S ribosomal protein S50101
30S ribosomal protein S80101
30S ribosomal protein S90101
50S ribosomal protein L130101
50S ribosomal protein L140101
50S ribosomal protein L160101
50S ribosomal protein L230101
30S ribosomal protein S150101
50S ribosomal protein L170101
50S ribosomal protein L210101
50S ribosomal protein L300101
50S ribosomal protein L60101
30S ribosomal protein S140101
30S ribosomal protein S170101
30S ribosomal protein S10101
50S ribosomal protein L180101
50S ribosomal protein L20101
50S ribosomal protein L30101
50S ribosomal protein L240101
50S ribosomal protein L40101
50S ribosomal protein L220101
50S ribosomal protein L50101
30S ribosomal protein S210101
50S ribosomal protein L250101
50S ribosomal protein L36 20101
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]