a-Synucleinopathies

Neurodegenerative disorders involving deposition of abnormal ALPHA-SYNUCLEIN in dopaminergic neurons and glial cells in the brain. Pathological aggregations of alpha-synuclein proteins results in LEWY BODIES and Lewy neurites; melanin granules in the SUBSTANTIA NIGRA and LOCUS COERULEUS; and glial cytoplasmic inclusions. Synucleinopathies are associated with mutation in the ALPHA-SYNUCLEIN (SNCA) gene on chromosome 4. PARKINSON DISEASE; LEWY BODY DISEASE with dementia; and MULTIPLE SYSTEM ATROPHY are prominent examples of synucleinopathy.

Synonym
alpha-Synucleinopathies
a-Synucleinopathies
Synucleinopathies
alpha Synuclein Pathology

Excerpt	Reference
"Synucleinopathies are composed of Parkinson disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy (MSA)."	( Bassil, F; Lee, VM; Lo, A; Luk, KC; Takahashi, R; Trojanowski, JQ; Uemura, MT; Uemura, N; Zhang, B, 2019)
"Synucleinopathies are conditions that remain with no available effective treatments thus far."	( Arevalo-Villalobos, JI; Govea Alonso, DO; Rosales-Mendoza, S, 2020)
"Synucleinopathies are a group of disorders characterized by the accumulation of inclusions rich in the a-synuclein (aSyn) protein."	( Brás, IC; Dominguez-Meijide, A; Gerhardt, E; Koss, D; Lázaro, DF; Outeiro, TF; Santos, PI; Vasili, E; Xylaki, M, 2020)
"α-Synucleinopathies are characterized by autonomic dysfunction and motor impairments."	( Ding, XB; Hao, MM; Jiang, XY; Li, JY; Ma, MM; Tang, BS; Teng, JF; Teng, RKF; Wang, XJ; Wu, E; Zhou, LB, 2020)
"Synucleinopathies are neurological diseases that are characterized by the accumulation of aggregates of a cytosolic protein, α-synuclein, at the plasma membrane."	( Heo, P; Pincet, F, 2020)
"Synucleinopathies are a group of neurodegenerative disorders caused by the misfolding and self-templating of the protein α-synuclein, or the formation of α-synuclein prions."	( Holec, SAM; Woerman, AL, 2021)
"Alpha-synucleinopathies are a group of progressive neurodegenerative disorders, characterized by intracellular deposits of aggregated α-synuclein (αS)."	( Bacioglu, M; Barth, M; Eisele, YS; Jucker, M; Kahle, PJ; Kronenberg-Versteeg, D; Mahler, J; Nilsson, KPR; Obermüller, U; Schweighauser, M; Shimshek, DR; Skodras, A; Tanriöver, G; Wegenast-Braun, BM, 2020)
"Synucleinopathies are neurodegenerative disorders characterized by abnormal α-synuclein deposition that include Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy."	( Adame, A; Beilina, A; Cookson, MR; Iba, M; Kaganovich, A; Kim, C; Kim, M; Kumaran, R; Kwon, S; Lee, SJ; Lee, WJ; Li, Y; Mamais, A; Masliah, E; Rissman, RA; Shin, SJ; Singleton, AB; Smith, N; You, S, 2020)
"Synucleinopathies are a group of neurodegenerative diseases characterized by the accumulation of α-synuclein aggregates in neurons, nerve fibers or glial cells."	( Bernal, L; Surguchev, AA; Surguchov, A, 2021)
"Synucleinopathies are neurodegenerative diseases that are associated with the misfolding and aggregation of α-synuclein (αSyn)."	( Fukuhara, T; Hatano, T; Hattori, N; Imai, Y; Nukina, N; Okuzumi, A; Ueno, S, 2021)
"Synucleinopathies are a heterogeneous group of neurodegenerative diseases with amyloid deposits that contain the α-synuclein (SNCA/α-Syn) protein as a common hallmark."	( Hoppe, SO; Nussbaum-Krammer, C; Uzunoğlu, G, 2021)
"Synucleinopathies are neurodegenerative disorders involving pathological alpha-synuclein (αSyn) protein, including dementia with Lewy bodies, multiple system atrophy and Parkinson's disease (PD)."	( Gentzel, RC; Jinn, S; Kahle, PJ; Ma, L; Marcus, JN; Schachter, JB; Smith, SM; Toolan, D, 2021)
"Synucleinopathies are clinically and pathologically heterogeneous disorders characterized by pathologic aggregates of α-synuclein in neurons and glia, in the form of Lewy bodies, Lewy neurites, neuronal cytoplasmic inclusions, and glial cytoplasmic inclusions."	( Dickson, DW; Koga, S; Kondru, N; Ross, OA; Sekiya, H, 2021)
"The synucleinopathies are a group of neurodegenerative diseases characterized by the oligomerization of alpha-synuclein protein in neurons or glial cells."	( Basharova, KS; Baydakova, GV; Bezrukova, AI; Emelyanov, AK; Fursova, IV; Gracheva, EV; Irishina, YA; Khublarova, LA; Krasakov, IV; Kudrevatykh, AV; Miliukhina, IV; Palchikova, EI; Pchelina, SN; Senkevich, KA; Timofeeva, AA; Usenko, TS; Zakharov, DV; Zakharova, EY; Zalutskaya, NM; Zhuravlev, AS, 2022)
"Synucleinopathies are a group of clinically and neuropathologically distinct protein misfolding diseases caused by unique α-synuclein conformations, or strains."	( Holec, SAM; Liu, SL; Woerman, AL, 2022)
"Synucleinopathies are a group of neurodegenerative diseases, characterized by the abnormal accumulation of the protein alpha-synuclein (aSyn)."	( Al-Azzani, M; König, A; Outeiro, TF, 2022)
"Synucleinopathies are a group of progressive neurodegenerative diseases known for the accumulation of insoluble aggregates containing the protein alpha-synuclein (aSyn)."	( da Fonseca, ACC; Domingues, R; Foguel, D; Outeiro, TF; Robbs, BK; Sant'Anna, R, 2022)
"Synucleinopathies are neurodegenerative disorders including Parkinson disease (PD), dementia with Lewy body (DLB), and multiple system atrophy (MSA) that involve deposits of the protein alpha-synuclein (α-syn) in the brain."	( Furukawa, Y; Hattori, N; Hiyama, A; Imamura, Y; Miyasaka, T; Nukina, N; Okuzumi, A; Yoshinaga, S, 2022)
"Synucleinopathies are a group of neurodegenerative disorders caused by the accumulation of toxic species of α-synuclein."	( Maruyama, W; Naoi, M; Shamoto-Nagai, M, 2022)
"The synucleinopathies are neurodegenerative disease caused by abnormal accumulation of the 140-amino acid-containing protein α-synuclein (αSyn), including Parkinson's disease (PD), diffuse Lewy body dementia (DLBD), and multiple system atrophy (MSA)."	( Cheng, A; Fukunaga, K, 2022)
"Synucleinopathies are disorders characterized by the abnormal accumulation of α-synuclein (aSyn)."	( Al-Azzani, M; Fischer, A; Gerhardt, E; Islam, MR; Jain, G; Outeiro, TF; Paiva, I; Schulze-Hentrich, JM; Vasili, E; Wassouf, Z; Xylaki, M, 2023)
"Synucleinopathies are a set of devastating neurodegenerative diseases that share a pathologic accumulation of the protein α-synuclein (α-syn)."	( Deyell, JS; Mao, X; Sriparna, M; Ying, M, 2023)
"Similarly, synucleinopathies are primarily characterized by abnormal deposition of misfolded α-synuclein in neurons and glial cells and, in the process, depleting the levels of the normal, soluble α-synuclein that the brain needs for many physiological functions."	( Russo, M; Sensi, SL; Tiraboschi, P, 2023)
"α-Synucleinopathies are spreading neurodegenerative disorders characterized by the intracellular accumulation of insoluble aggregates populated by α-Synuclein (α-Syn) fibrils."	( De Giorgi, F; De Nuccio, F; Ichas, F; Kashyrina, M; Laferrière, F; Lofrumento, DD; Serinelli, F, 2023)
"Synucleinopathies are a group of neurodegenerative disorders that are pathologically characterized by intracellular aggregates called Lewy bodies."	( Arlinghaus, R; Cookson, MR; Iba, M; Landeck, N; Masliah, E, 2023)
"Synucleinopathies are a group of neurodegenerative diseases without effective treatment characterized by the abnormal aggregation of alpha-synuclein (aSyn) protein."	( Aragón, T; Arrasate, M; Aymerich, MS; Basurco, L; Boncristiani, C; Bravo-González, JJ; Fernández-Irigoyen, J; González-Aseguinolaza, G; Luquin, MR; Marcilla, I; Pérez-Mediavilla, A; Santamaría, E; Vales, A; Vinueza-Gavilanes, R, 2023)
"Synucleinopathies are characterized by the accumulation of α-synuclein (α-Syn) aggregates in the brain."	( Ahn, EH; Bu, L; Cao, X; Guan, Y; Kang, SS; Li, B; Li, D; Liu, C; Liu, X; Luo, S; Sun, Y; Tao, Y; Wang, X; Wu, S; Xia, W; Xia, Y; Xiang, J; Xie, F; Yang, JJ; Ye, K; Zhang, M; Zhang, X; Zhang, Z; Zhao, Q, 2023)
"Synucleinopathies are a group of neurodegenerative disorders, classically characterized by the accumulation of aggregated alpha synuclein (aSyn) in the central nervous system."	( Ebbinghaus, LS; Masanetz, RK; Rosshart, SP; Schmitt, V; Süß, P; von Hörsten, S; Weidenfeller, M; Winkler, J; Xiang, W; Zunke, F, 2023)
"α-Synucleinopathies are a group of neurodegenerative disorders characterized by alterations in α-synuclein (α-syn), a protein associated with membrane phospholipids, whose precise function in normal cells is still unknown."	( Castañeda-Cabral, JL; Lomeli-Lepe, AK; López-Pérez, SJ, 2023)
"The α-synucleinopathies are a group of neurodegenerative diseases characterized by the deposition of α-synuclein aggregates (α-syn) in the brain."	( Ågren, H; Hooshyar Yousefi, B; Li, J; Paslawski, W; Svenningsson, P; Uzuegbunam, BC; Weber, W, 2023)

Excerpt	Reference
"These diseases, called synucleinopathies, have overlapping symptoms but require different methods of treatment."	( Surguchov, A, 2020)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	0 (0.00)	23.3326
1990's	0 (0.00)	12.5806
2000's	0 (0.00)	18.1394
2010's	64 (14.35)	28.8240
2020's	382 (85.65)	9.53

Drug	Relationship Strength	Studies	Trials
allantoin	low	1	0
carbamates	low	1	0
coumarin	low	1	0
3,4-dihydroxyphenylacetic acid	low	1	0
dimethyl sulfoxide	low	1	0
formaldehyde	low	1	0
melatonin	low	1	0
nickel	low	1	0
pyridine	low	1	0
uric acid	low	1	0
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine	low	1	0
homovanillic acid	low	1	0
benzo(a)pyrene	low	1	0
caffeine	low	1	0
chlorpromazine	low	1	0
clonazepam	low	1	0
dsp 4	low	1	0
methylphenidate	low	1	0
midodrine	low	1	0
oxidopamine	low	2	0
prazosin	low	1	0
terazosin	low	1	0
mitomycin	low	1	0
corticosterone	low	1	0
serine	low	2	0
glutamine	low	1	0
lysine	low	1	0
levodopa	low	1	0
tyrosine	low	1	0
methylene blue	low	1	0
rotenone	low	1	0
quinuclidines	low	1	0
quinazolines	low	1	0
benzoxazoles	low	1	0
methoxyhydroxyphenylglycol	low	1	0
methamphetamine	low	1	0
3-hydroxyflavone	low	1	0
thioflavin t	low	3	0
manganese	low	1	0
mercury	low	1	0
palladium	low	1	0
silver	low	1	0
cadmium	low	1	0
chromium	low	1	0
vanadium	low	1	0
selegiline	low	1	0
transferrin	low	1	0
3-iodobenzylguanidine	low	1	0
delphinidin	low	1	0
fluorodeoxyglucose f18	low	2	0
3,4-dihydroxyphenylglycol	low	1	0
droxidopa	low	1	0
cobalt	low	1	0
lanthionine ketimine	low	1	0
ampelopsin	low	1	0
hydromethylthionine	low	1	0
benzofurans	low	1	0
fusicoccin	low	1	0
arachidonic acid	low	1	0
cocaine	low	1	0
chalcone	low	1	0
s 1033	low	1	0
dieldrin	low	1	0
rasagiline	low	1	0
cholecalciferol	low	1	0
lead	low	2	0
antimony	low	1	0
barium	low	1	0
aluminum	low	1	0
arsenic	low	1	0
beryllium	low	1	0
radium	low	1	0
sphingosyl beta-glucoside	low	1	0
salvianolic acid B	low	1	0
perampanel	low	1	0
2-carbomethoxy-8-(3-fluoropropyl)-3-(4-iodophenyl)tropane	low	2	0
alpha-synuclein	medium	430	1
nad	low	1	0
calpain	low	2	0
piperidines	low	1	0
3-(1,3-benzodioxol-5-yl)-5-(3-bromophenyl)-1h-pyrazole	medium	1	1
exenatide	low	1	0
warfarin	low	1	0
demeclocycline	low	1	0
azd3759	low	1	0
amyloid beta-peptides	low	1	0

Protein Targets (1,231)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Dihydropteridine reductase	0	1	0	1
Amine oxidase [flavin-containing] A	0	8	0	9
Amine oxidase [flavin-containing] B	0	9	1	10
Amine oxidase [flavin-containing] B	0	5	0	6
Sodium-dependent dopamine transporter	0	7	0	7
Alpha-synuclein	2	2	1	5
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	8	0	0	8
Chain A, 2-oxoglutarate Oxygenase	11	0	0	11
glp-1 receptor, partial	3	0	0	3
USP1 protein, partial	7	0	0	7
TDP1 protein	11	0	0	11
Smad3	5	0	0	5
apical membrane antigen 1, AMA1	4	0	0	4
cellular tumor antigen p53 isoform a	4	0	0	4
importin subunit beta-1 isoform 1	3	0	0	3
mitogen-activated protein kinase 1	5	0	0	5
snurportin-1	3	0	0	3
GTP-binding nuclear protein Ran isoform 1	2	0	0	2
DNA polymerase eta isoform 1	4	0	0	4
DNA polymerase iota isoform a (long)	9	0	0	9
urokinase-type plasminogen activator precursor	5	0	0	5
plasminogen precursor	5	0	0	5
urokinase plasminogen activator surface receptor precursor	5	0	0	5
nuclear receptor ROR-gamma isoform 1	6	0	0	6
geminin	13	0	0	13
cytochrome P450 3A4 isoform 1	8	0	0	8
lamin isoform A-delta10	10	0	0	10
Gamma-aminobutyric acid receptor subunit pi	8	1	0	9
Polyunsaturated fatty acid lipoxygenase ALOX15B	4	1	0	5
Carbonic anhydrase 12	0	3	0	6
Carbonic anhydrase 1	0	4	0	8
Carbonic anhydrase 2	0	4	0	8
Integrin beta-3	3	0	0	3
ATP-dependent translocase ABCB1	0	1	1	4
Integrin alpha-IIb	3	0	0	3
Calmodulin-1	0	3	1	4
Androgen receptor	0	1	0	1
Pyruvate kinase PKM	0	2	1	3
Gamma-aminobutyric acid receptor subunit beta-1	8	1	0	9
Polyunsaturated fatty acid lipoxygenase ALOX15	0	1	0	1
Polyunsaturated fatty acid lipoxygenase ALOX12	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	8	1	0	9
Gamma-aminobutyric acid receptor subunit gamma-2	8	1	0	9
Gamma-aminobutyric acid receptor subunit alpha-5	8	1	0	9
Gamma-aminobutyric acid receptor subunit alpha-3	8	1	0	9
Gamma-aminobutyric acid receptor subunit gamma-1	8	1	0	9
Gamma-aminobutyric acid receptor subunit alpha-2	8	1	0	9
Gamma-aminobutyric acid receptor subunit alpha-4	8	1	0	9
Gamma-aminobutyric acid receptor subunit gamma-3	8	1	0	9
Gamma-aminobutyric acid receptor subunit alpha-6	8	1	0	9
Histamine H2 receptor	5	0	0	5
Xanthine dehydrogenase/oxidase	0	1	0	1
Fatty acid synthase	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	8	1	0	9
Gamma-aminobutyric acid receptor subunit beta-3	8	1	0	9
Gamma-aminobutyric acid receptor subunit beta-2	8	1	0	9
Cytochrome P450 1B1	0	2	0	2
Carbonic anhydrase 9	0	3	0	6
GABA theta subunit	8	1	0	9
Aurora kinase B	0	1	1	2
Gamma-aminobutyric acid receptor subunit epsilon	8	1	0	9
Dipeptidyl peptidase 3	0	1	0	1
HSP40, subfamily A [Plasmodium falciparum 3D7]	0	0	0	1
dopamine D1 receptor	3	0	0	3
thioredoxin reductase	15	0	0	15
GLS protein	9	0	0	9
Thrombopoietin	4	0	0	4
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	5	0	0	5
cytochrome P450 2D6 isoform 1	4	0	0	4
cytochrome P450 2C19 precursor	3	0	0	3
ras-related protein Rab-9A	5	0	0	5
histone acetyltransferase KAT2A isoform 1	4	0	0	4
lethal factor (plasmid)	7	0	0	7
POU domain, class 2, transcription factor 1	0	0	0	1
Spike glycoprotein	7	1	1	9
ATP-dependent phosphofructokinase	10	0	0	10
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	11	0	0	11
Chain A, HADH2 protein	9	0	0	9
Chain B, HADH2 protein	9	0	0	9
Chain A, JmjC domain-containing histone demethylation protein 3A	5	0	0	5
Chain A, Protocatechuate 3,4-dioxygenase	0	0	1	1
Chain M, Protocatechuate 3,4-dioxygenase	0	0	1	1
Olfactory receptor class A-like protein 1	0	0	1	1
Luciferase	7	0	0	7
endonuclease IV	1	0	0	1
RGS12	2	0	0	2
phosphopantetheinyl transferase	10	0	0	10
NFKB1 protein, partial	5	0	0	5
Microtubule-associated protein tau	8	0	0	8
alkaline phosphatase, intestinal	0	0	1	1
thioredoxin glutathione reductase	4	0	0	4
thyroid stimulating hormone receptor	5	0	0	5
hypothetical protein, conserved	2	0	0	2
regulator of G-protein signaling 4	7	0	0	7
euchromatic histone-lysine N-methyltransferase 2	17	0	0	17
Bloom syndrome protein isoform 1	8	0	0	8
lysosomal alpha-glucosidase preproprotein	4	0	0	4
peripheral myelin protein 22 isoform 1	4	0	0	4
alkaline phosphatase, tissue-nonspecific isozyme isoform 1 preproprotein	0	1	0	1
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	6	0	0	6
intestinal alkaline phosphatase precursor	0	1	0	1
chromobox protein homolog 1	12	0	0	12
guanine nucleotide-binding protein G(i) subunit alpha-1 isoform 1	1	0	0	1
DNA polymerase beta	4	0	0	4
flap endonuclease 1	5	0	0	5
M-phase phosphoprotein 8	7	0	0	7
alkaline phosphatase, germ cell type preproprotein	0	0	1	1
POsterior Segregation	0	0	2	2
muscarinic acetylcholine receptor M1	8	0	0	8
Prolyl 4-hydroxylase subunit alpha-1	0	1	0	1
Sodium-dependent noradrenaline transporter	0	6	3	9
Zinc finger protein mex-5	0	0	2	2
GLI family zinc finger 3	13	0	0	13
AR protein	14	0	0	14
estrogen receptor 2 (ER beta)	7	0	0	7
cytochrome P450 family 3 subfamily A polypeptide 4	8	0	0	8
estrogen nuclear receptor alpha	16	0	0	16
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	9	0	0	9
vitamin D3 receptor isoform VDRA	7	0	0	7
thyroid hormone receptor beta isoform 2	11	0	0	11
EWS/FLI fusion protein	8	0	0	8
Replicase polyprotein 1ab	0	2	1	3
Synaptojanin-2	0	1	0	1
Synaptojanin-1	0	1	0	1
Amyloid-beta precursor protein	0	4	0	4
Replicase polyprotein 1ab	0	4	1	5
Chain A, ADIPOCYTE LIPID-BINDING PROTEIN	0	0	1	1
Chain A, SERUM ALBUMIN	0	0	1	1
Chain A, SERUM ALBUMIN	0	0	1	1
Chain A, Beta-lactamase	4	0	0	4
Chain A, ATP-DEPENDENT DNA HELICASE Q1	6	0	0	6
Chain A, Cruzipain	3	0	0	3
15-lipoxygenase, partial	4	0	0	4
aldehyde dehydrogenase 1 family, member A1	8	0	0	8
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	2	0	0	2
ubiquitin carboxyl-terminal hydrolase 2 isoform a	2	0	0	2
lethal(3)malignant brain tumor-like protein 1 isoform I	1	0	0	1
DNA polymerase kappa isoform 1	8	0	0	8
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	2	0	0	2
caspase-1 isoform alpha precursor	1	0	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
Prostaglandin G/H synthase 1	0	0	0	1
Trypsin	0	1	0	1
Coagulation factor VII	0	1	0	1
60 kDa chaperonin	0	2	0	2
60 kDa heat shock protein, mitochondrial	0	2	0	2
Aromatase	0	2	0	2
Tissue factor	0	1	0	1
Fatty acid-binding protein, adipocyte	0	1	1	2
Prostaglandin G/H synthase 2	0	0	2	3
Nuclear receptor subfamily 4 group A member 2	0	0	1	1
10 kDa heat shock protein, mitochondrial	0	2	0	2
Calmodulin	0	1	1	3
Disintegrin and metalloproteinase domain-containing protein 17	1	0	0	1
Prostaglandin G/H synthase 2	0	0	0	1
Solute carrier organic anion transporter family member 2A1	0	0	0	1
Fatty acid-binding protein 5	0	1	0	1
Fatty acid-binding protein 5	0	0	1	1
Thiosulfate sulfurtransferase	0	2	0	2
Lanosterol 14-alpha demethylase	0	1	0	1
60 kDa chaperonin	0	2	0	2
10 kDa chaperonin	0	2	0	2
Solute carrier organic anion transporter family member 1B3	0	2	0	2
Cytosolic phospholipase A2 gamma	0	1	0	1
Transient receptor potential cation channel subfamily V member 2	0	1	0	1
Solute carrier organic anion transporter family member 1B1	0	2	0	2
Epidermal growth factor receptor	0	5	1	6
Receptor tyrosine-protein kinase erbB-2	0	3	1	4
Cytochrome P450 1A2	0	3	1	4
Cytochrome P450 3A4	0	4	1	5
Cytochrome P450 2C8	0	1	0	1
Cytochrome P450 2D6	0	3	1	4
Cytochrome P450 2C9	0	3	0	3
Proto-oncogene tyrosine-protein kinase Src	0	3	1	4
D(2) dopamine receptor	0	3	0	4
Cytochrome P450 2B6	0	1	0	1
Cytochrome P450 3A5	0	1	0	1
Receptor tyrosine-protein kinase erbB-3	0	1	1	2
Cytochrome P450 2C19	0	2	0	2
Vascular endothelial growth factor receptor 2	0	2	1	3
Receptor tyrosine-protein kinase erbB-4	0	1	1	2
acid sphingomyelinase	2	0	0	2
acetylcholinesterase	5	0	0	5
hypoxia-inducible factor 1 alpha subunit	5	0	0	5
RAR-related orphan receptor gamma	12	0	0	12
SMAD family member 2	4	0	0	4
SMAD family member 3	4	0	0	4
caspase 7, apoptosis-related cysteine protease	6	0	0	6
nuclear receptor subfamily 1, group I, member 3	9	0	0	9
progesterone receptor	8	0	0	8
glucocorticoid receptor [Homo sapiens]	13	0	0	13
retinoic acid nuclear receptor alpha variant 1	11	0	0	11
retinoid X nuclear receptor alpha	11	0	0	11
estrogen-related nuclear receptor alpha	10	0	0	10
farnesoid X nuclear receptor	11	0	0	11
pregnane X nuclear receptor	11	0	0	11
peroxisome proliferator-activated receptor delta	7	0	0	7
peroxisome proliferator activated receptor gamma	8	0	0	8
vitamin D (1,25- dihydroxyvitamin D3) receptor	11	0	0	11
caspase-3	6	0	0	6
aryl hydrocarbon receptor	5	0	0	5
activating transcription factor 6	2	0	0	2
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	6	0	0	6
v-jun sarcoma virus 17 oncogene homolog (avian)	6	0	0	6
nuclear factor erythroid 2-related factor 2 isoform 2	5	0	0	5
heat shock protein beta-1	6	0	0	6
nuclear factor erythroid 2-related factor 2 isoform 1	10	0	0	10
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	4	0	0	4
DNA dC->dU-editing enzyme APOBEC-3F isoform a	2	0	0	2
Voltage-dependent calcium channel gamma-2 subunit	6	0	0	6
Cellular tumor antigen p53	10	0	0	10
Tyrosine-protein kinase Fyn	0	3	1	4
Glutamate receptor 2	7	0	0	7
Acetylcholinesterase	0	6	0	6
Aryl hydrocarbon receptor	0	0	1	1
Chain A, Glycogen Phosphorylase	0	1	0	1
Chain A, Glycogen phosphorylase, liver form	0	0	2	2
Chain A, glycogen phosphorylase, liver form	0	0	2	2
Chain A, Glycogen phosphorylase, liver form	0	0	2	2
Chain A, Glycogen phosphorylase, liver form	0	0	2	2
Chain A, Chitinase	0	1	0	1
thyroid stimulating hormone receptor	6	0	0	6
atrial natriuretic peptide receptor 1 precursor	3	0	0	3
thyroid hormone receptor beta isoform a	8	0	0	8
ATP-binding cassette sub-family C member 3	0	7	0	7
Multidrug resistance-associated protein 4	0	7	0	7
Potassium channel subfamily K member 2	0	1	1	2
Bile salt export pump	0	9	0	9
Glycogen phosphorylase, muscle form	0	1	0	1
Renin	0	1	0	1
Cholinesterase	0	6	0	6
Glycogen phosphorylase, liver form	0	1	0	1
Glycogen phosphorylase, muscle form	0	1	0	1
Replicase polyprotein 1ab	0	2	1	3
Adenosine receptor A3	0	1	0	1
Adenosine receptor A1	0	3	0	6
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	2	0	2
Adenosine receptor A3	0	1	0	1
Adenosine receptor A2a	0	2	1	4
Adenosine receptor A2b	0	1	0	2
Adenosine receptor A2b	0	2	0	3
Adenosine receptor A1	0	1	1	4
Adenosine receptor A2a	0	2	0	6
Vasopressin V2 receptor	0	0	0	1
Serine/threonine-protein kinase mTOR	0	1	1	2
Adenosine receptor A2a	0	1	0	1
Adenosine receptor A1	0	1	0	1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	0	1	1	2
DNA-dependent protein kinase catalytic subunit	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	1	0	1
Adenylate cyclase type 1	0	0	0	1
Chitotriosidase-1	0	1	0	1
Serine-protein kinase ATM	0	1	0	1
Serine/threonine-protein kinase ATR	0	1	0	1
Adenosine receptor A2b	0	1	0	2
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	0	1	0	1
Palmitoleoyl-protein carboxylesterase NOTUM	0	2	2	4
Endochitinase B1	0	1	0	1
Muscarinic acetylcholine receptor	0	0	0	1
Canalicular multispecific organic anion transporter 1	0	6	0	6
Phosphodiesterase	0	1	0	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	2	0	3
Guanine deaminase	0	2	0	2
ATAD5 protein, partial	7	0	0	7
nonstructural protein 1	3	0	0	3
pyruvate kinase	2	0	0	2
IDH1	5	0	0	5
perilipin-5	0	1	0	1
perilipin-1	0	1	0	1
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a	0	1	0	1
Thioredoxin reductase 1, cytoplasmic	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Pancreatic triacylglycerol lipase	0	2	0	2
Pancreatic alpha-amylase	0	1	0	1
Acetylcholinesterase	0	1	0	1
Tubulin beta-4A chain	0	1	0	1
Tubulin beta chain	0	1	0	1
Tubulin alpha-3C chain	0	1	0	1
Androgen receptor	0	4	0	4
Tumor necrosis factor receptor superfamily member 1A	0	1	0	1
Endothelin receptor type B	1	0	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Endothelin-1 receptor	1	0	0	1
Substance-P receptor	0	0	0	2
Quinone oxidoreductase	0	0	0	2
Stromal cell-derived factor 1	0	1	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	1
Tubulin alpha-1B chain	0	1	0	1
Tubulin alpha-4A chain	0	1	0	1
Tubulin beta-4B chain	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
Tubulin beta-3 chain	0	1	0	1
Tubulin beta-2A chain	0	1	0	1
Tubulin beta-8 chain	0	1	0	1
Tubulin alpha-3E chain	0	1	0	1
Tubulin alpha-1A chain	0	1	0	1
Sortase A	0	1	0	1
Tubulin alpha-1C chain	0	1	0	1
Tubulin beta-6 chain	0	1	0	1
Tubulin beta-2B chain	0	1	0	1
Tubulin beta-1 chain	0	1	0	1
Proteasome subunit beta type-11	0	0	0	1
Fumarate hydratase	8	0	0	8
NADPH oxidase 1	0	1	0	1
G	6	0	0	6
cytochrome P450 2D6	3	0	0	3
polyprotein	8	0	0	8
67.9K protein	3	0	0	3
Snq2p	0	0	0	1
Adenylate cyclase type 1	0	2	0	2
Histone H2A.x	5	0	0	5
Caspase-7	2	0	0	2
Spike glycoprotein	0	1	1	2
D(1A) dopamine receptor	4	0	0	4
potassium voltage-gated channel subfamily H member 2 isoform d	3	0	0	3
caspase-3	2	0	0	2
histone deacetylase 9 isoform 3	3	0	0	3
atrial natriuretic peptide receptor 2 precursor	2	0	0	2
serine/threonine-protein kinase mTOR isoform 1	4	0	0	4
peripheral myelin protein 22	4	0	0	4
survival motor neuron protein isoform d	6	0	0	6
Proteasome subunit alpha type-7	0	0	0	1
Solute carrier family 22 member 1	0	5	0	5
Transmembrane protease serine 2	0	1	1	2
Glutamate receptor ionotropic, NMDA 2D	0	1	0	1
Transient receptor potential cation channel subfamily V member 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1F	0	2	0	2
Bile salt export pump	0	1	0	1
5-hydroxytryptamine receptor 4	0	2	0	2
Interferon beta	8	0	0	8
HLA class I histocompatibility antigen, B alpha chain	6	0	0	6
Albumin	0	0	2	2
Albumin	0	0	2	2
Major prion protein	0	0	1	1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	0	1	0	1
Major prion protein	0	0	1	1
Procathepsin L	0	1	1	2
Aldo-keto reductase family 1 member B1	0	2	0	2
Muscarinic acetylcholine receptor M2	0	2	0	2
Muscarinic acetylcholine receptor M4	0	2	0	2
Muscarinic acetylcholine receptor M1	0	2	0	2
Muscarinic acetylcholine receptor M3	0	1	0	1
Muscarinic acetylcholine receptor M4	0	1	0	1
5-hydroxytryptamine receptor 1A	0	2	0	2
5-hydroxytryptamine receptor 2C	0	5	0	5
Muscarinic acetylcholine receptor M5	0	1	0	1
Muscarinic acetylcholine receptor M5	0	2	0	2
Alpha-2A adrenergic receptor	0	8	0	9
Replicase polyprotein 1a	0	1	1	2
Replicase polyprotein 1ab	0	1	1	2
Cys-loop ligand-gated ion channel	0	1	0	1
Muscarinic acetylcholine receptor M2	0	1	0	1
Muscarinic acetylcholine receptor M1	0	2	0	2
Polyunsaturated fatty acid lipoxygenase ALOX15	0	2	0	2
Angiotensin-converting enzyme	0	4	0	4
5-hydroxytryptamine receptor 2A	0	4	0	4
Alpha-1B adrenergic receptor	0	6	2	8
Sphingomyelin phosphodiesterase	0	1	0	1
Alpha-2B adrenergic receptor	0	8	0	9
Alpha-2C adrenergic receptor	0	6	0	7
D	0	4	0	4
D(3) dopamine receptor	0	2	0	2
5-hydroxytryptamine receptor 1A	0	4	0	4
Alpha-2B adrenergic receptor	0	5	2	7
D(2) dopamine receptor	0	1	0	1
Muscarinic acetylcholine receptor M3	0	2	0	2
Proteasome subunit beta type-1	0	0	0	1
Substance-K receptor	0	2	0	2
D(1A) dopamine receptor	0	2	0	3
D(4) dopamine receptor	0	3	0	4
D(1B) dopamine receptor	0	1	0	2
Adenylate cyclase type 3	0	2	0	2
Alpha-2C adrenergic receptor	0	5	2	7
UDP-glucuronosyltransferase 1A4	0	1	0	2
Alpha-2A adrenergic receptor	0	5	2	7
Alpha-1D adrenergic receptor	0	6	2	8
Sodium-dependent dopamine transporter	0	6	0	6
Histamine H2 receptor	0	2	0	2
Alpha-1D adrenergic receptor	0	6	2	10
D(1B) dopamine receptor	0	2	0	2
Proteasome subunit alpha type-1	0	0	0	1
Proteasome subunit alpha type-2	0	0	0	1
Proteasome subunit alpha type-3	0	0	0	1
Proteasome subunit alpha type-4	0	0	0	1
Adenylate cyclase type 2	0	2	0	2
Adenylate cyclase type 4	0	2	0	2
Proteasome subunit beta type-8	0	0	0	1
Proteasome subunit beta type-9	0	0	0	1
Proteasome subunit alpha type-5	0	0	0	1
Proteasome subunit beta type-4	0	0	0	1
Proteasome subunit beta type-6	0	0	0	1
Proteasome subunit beta type-5	0	0	0	1
5-hydroxytryptamine receptor 2A	0	2	0	2
5-hydroxytryptamine receptor 2C	0	2	0	2
5-hydroxytryptamine receptor 1B	0	4	0	4
Trypanothione reductase	0	2	0	2
D(4) dopamine receptor	0	2	0	2
5-hydroxytryptamine receptor 2B	0	4	0	4
Histamine H1 receptor	0	1	0	1
Sodium-dependent serotonin transporter	0	6	1	7
Melanocortin receptor 4	0	2	0	2
5-hydroxytryptamine receptor 7	0	2	0	2
Melanocortin receptor 5	0	2	0	2
Pleiotropic ABC efflux transporter of multiple drugs	0	1	0	2
5-hydroxytryptamine receptor 7	0	1	0	1
Histamine H1 receptor	0	2	0	2
Mu-type opioid receptor	0	2	0	2
Glutamate receptor ionotropic, NMDA 1	0	2	0	4
D(3) dopamine receptor	0	3	0	4
Sodium channel protein type 1 subunit alpha	0	1	0	1
Sodium channel protein type 4 subunit alpha	0	1	0	1
Adenylate cyclase type 8	0	2	0	2
Proteasome subunit beta type-10	0	0	0	1
Delta-type opioid receptor	0	2	0	2
Kappa-type opioid receptor	0	2	0	2
5-hydroxytryptamine receptor 2B	0	4	0	4
Melanocortin receptor 3	0	2	0	2
Alpha-1A adrenergic receptor	0	7	2	9
Proteasome subunit beta type-3	0	0	0	1
Proteasome subunit beta type-2	0	0	0	1
D(1A) dopamine receptor	3	0	0	3
5-hydroxytryptamine receptor 6	0	5	0	5
5-hydroxytryptamine receptor 7	0	3	0	3
Cytochrome P450 2J2	0	1	0	1
Gastrin/cholecystokinin type B receptor	0	1	0	1
Proteasome subunit alpha type-6	0	0	1	2
D(2) dopamine receptor	0	5	0	6
Aldehyde oxidase 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	2	0	4
Glutamate receptor ionotropic, NMDA 2B	0	2	0	4
Glutamate receptor ionotropic, NMDA 2C	0	2	0	4
Sodium channel protein type 7 subunit alpha	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	2	0	2
Adenylate cyclase type 6	0	2	0	2
Adenylate cyclase type 5	0	2	0	2
Glutamate receptor ionotropic, NMDA 1	0	1	0	1
Aldehyde oxidase	0	2	0	2
Potassium voltage-gated channel subfamily H member 2	0	7	0	7
Glutamate receptor ionotropic, NMDA 2A	0	1	0	1
Glutamate receptor ionotropic, NMDA 2B	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1C	0	2	0	2
Sodium channel protein type 5 subunit alpha	0	2	0	2
Glutamate receptor ionotropic, NMDA 2C	0	1	0	1
Sodium channel protein type 9 subunit alpha	0	1	0	1
Glutamate receptor ionotropic, NMDA 2D	0	2	0	4
Nuclear receptor subfamily 3 group C member 3	0	4	0	4
Adenylyl cyclase 7	0	2	0	2
Proteasome subunit alpha-type 8	0	0	0	1
Glutamate receptor ionotropic, NMDA 3A	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	2	0	4
Inositol hexakisphosphate kinase 1	6	0	0	6
D	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	1	0	1
Proteasome subunit beta type-7	0	0	0	1
Ataxin-2	4	0	0	4
Sigma non-opioid intracellular receptor 1	0	6	0	6
Angiotensin-converting enzyme 2	0	1	1	2
Sodium channel protein type 3 subunit alpha	0	1	0	1
Glutamate receptor ionotropic, NMDA 3A	0	2	0	4
Sodium channel protein type 11 subunit alpha	0	1	0	1
Sodium channel protein type 8 subunit alpha	0	1	0	1
Histamine H3 receptor	0	2	0	2
Sodium channel protein type 10 subunit alpha	0	1	0	1
cytochrome P450 2C9, partial	6	0	0	6
Chain A, Ferritin light chain	4	0	0	4
interleukin 8	2	0	0	2
Vitamin D3 receptor	0	1	1	4
Glycine receptor subunit alpha-1	0	0	1	1
Vitamin D3 receptor	0	0	1	1
Nuclear receptor ROR-gamma	3	0	0	3
Gamma-aminobutyric acid receptor subunit pi	0	3	0	3
Gamma-aminobutyric acid receptor subunit delta	0	3	0	3
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-4	1	1	0	2
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	0	1
Neuronal acetylcholine receptor subunit beta-2	1	1	0	2
Gamma-aminobutyric acid receptor subunit alpha-1	0	3	0	3
Gamma-aminobutyric acid receptor subunit beta-1	0	3	0	3
Gamma-aminobutyric acid receptor subunit gamma-2	0	3	0	3
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-3	0	3	0	3
Translocator protein	0	1	0	1
Translocator protein	0	1	0	1
Cholecystokinin receptor type A	0	1	0	1
Gastrin/cholecystokinin type B receptor	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	3	0	3
Gamma-aminobutyric acid receptor subunit alpha-3	0	3	0	3
Gamma-aminobutyric acid receptor subunit alpha-2	0	3	0	3
Gamma-aminobutyric acid receptor subunit beta-2	0	3	0	3
Gamma-aminobutyric acid receptor subunit alpha-4	0	3	0	3
Gamma-aminobutyric acid receptor subunit epsilon	0	3	0	3
Gamma-aminobutyric acid receptor subunit alpha-6	0	3	0	3
Gamma-aminobutyric acid receptor subunit gamma-1	0	3	0	3
Gamma-aminobutyric acid receptor subunit gamma-3	0	3	0	3
Gamma-aminobutyric acid receptor subunit theta	0	3	0	3
Chain A, CHIMERA OF IG KAPPA CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION	0	0	1	1
Chain B, CHIMERA OF IG GAMMA-1 CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION	0	0	1	1
Chain H, Fab M82G2, Heavy chain	0	0	1	1
Chain L, Fab M82G2, Light chain	0	0	1	1
Chain H, Fab M82g2, Heavy Chain	0	0	1	1
Chain L, Fab M82g2, Light Chain	0	0	1	1
Fatty acid-binding protein, heart	0	1	0	1
Muscarinic acetylcholine receptor M2	0	1	0	1
Tryptophan 5-hydroxylase 1	0	1	0	1
Liver carboxylesterase 1	0	0	0	1
5-hydroxytryptamine receptor 1D	0	2	0	2
5-hydroxytryptamine receptor 1F	0	2	0	2
5-hydroxytryptamine receptor 6	0	1	0	1
Sodium-dependent serotonin transporter	0	2	0	3
5-hydroxytryptamine receptor 5A	0	1	0	1
5-hydroxytryptamine receptor 5B	0	1	0	1
5-hydroxytryptamine receptor 3A	0	1	0	1
Lysosomal Pro-X carboxypeptidase	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
Leukotriene B4 receptor 1	0	1	0	1
Sodium-dependent dopamine transporter	0	2	0	2
5-hydroxytryptamine receptor 4	0	1	0	1
5-hydroxytryptamine receptor 3B	0	1	0	1
Leukotriene B4 receptor 2	0	1	0	1
Transporter	0	3	0	3
pregnane X receptor	3	0	0	3
GALC protein	2	0	0	2
Solute carrier family 22 member 2	0	2	0	2
Solute carrier family 22 member 3	0	3	0	3
Solute carrier family 22 member 3	0	2	0	2
Sex hormone-binding globulin	0	0	1	1
Corticosteroid-binding globulin	0	1	0	1
Mineralocorticoid receptor	0	0	1	1
C-8 sterol isomerase	0	1	0	1
Solute carrier organic anion transporter family member 1A1	0	1	0	1
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	0	1	0	1
Solute carrier family 22 member 1	0	2	0	2
Solute carrier family 22 member 2	0	2	0	2
nuclear receptor subfamily 1, group I, member 2	2	0	0	2
glycogen synthase kinase-3 alpha	0	0	0	1
muscleblind-like protein 1 isoform 1	2	0	0	2
Exportin-1	0	1	0	1
Glyceraldehyde-3-phosphate dehydrogenase	0	2	0	2
NAD-dependent histone deacetylase SIR2	0	1	0	3
Carbonic anhydrase 3	0	2	0	4
Cytochrome P450 2A6	0	0	0	1
Aldo-keto reductase family 1 member B1	0	1	0	1
UDP-glucuronosyltransferase 2B7	0	1	0	1
UDP-glucuronosyltransferase 1-6	0	1	0	1
Amine oxidase [flavin-containing] B	0	6	0	7
Cytochrome P450 2A5	0	0	0	1
Amine oxidase [flavin-containing] A	0	5	0	6
Acetylcholinesterase	0	1	0	1
UDP-glucuronosyltransferase 1A1	0	1	0	1
Glyceraldehyde-3-phosphate dehydrogenase, glycosomal	0	1	0	1
Carbonic anhydrase 4	0	2	0	4
Carbonic anhydrase 6	0	2	0	4
Carbonic anhydrase 5A, mitochondrial	0	2	0	4
UDP-glucuronosyltransferase 2B10	0	1	0	1
Carbonic anhydrase 7	0	2	0	4
Beta-secretase 1	0	1	0	1
Sorbitol dehydrogenase	0	1	0	1
Induced myeloid leukemia cell differentiation protein Mcl-1	0	2	0	2
Zn finger protein	0	1	0	1
Dihydroorotate dehydrogenase	0	1	0	1
Carbonic anhydrase 13	0	1	0	1
Carbonic anhydrase 15	0	2	0	4
Carbonic anhydrase 13	0	2	0	3
Carbonic anhydrase 14	0	2	0	4
Carbonic anhydrase 5B, mitochondrial	0	2	0	4
Lactoylglutathione lyase	0	1	0	1
Histone acetyltransferase p300	0	1	0	1
CREB-binding protein	0	1	0	1
arylsulfatase A	7	0	0	7
hexokinase-4 isoform 1	2	0	0	2
glucokinase regulatory protein	2	0	0	2
thyrotropin-releasing hormone receptor	1	0	0	1
Mitogen-activated protein kinase 14	0	1	2	3
Cereblon isoform 4	0	2	0	2
Insulin-like growth factor-binding protein 5	0	0	1	1
Choline O-acetyltransferase	0	1	0	1
Protein cereblon	0	2	0	2
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Chain A, Glutamine Binding Protein	0	0	1	1
histone-lysine N-methyltransferase 2A isoform 2 precursor	2	0	0	2
Neutral amino acid transporter A	0	2	0	2
Asc-type amino acid transporter 1	0	1	0	1
Neutral amino acid transporter B(0)	0	2	0	2
Carbonic anhydrase-like protein, putative	0	0	0	3
Amino acid transporter	0	2	0	2
ClpP	2	0	0	2
Solute carrier family 22 member 8	0	0	0	1
Chain A, Acetylcholinesterase	0	1	0	1
WRN	1	0	0	1
integrase, partial	0	2	0	2
lens epithelium-derived growth factor p75	0	2	0	2
Polyphenol oxidase 2	0	0	0	2
Plasma kallikrein	0	0	0	2
Tyrosine-protein kinase Lck	0	3	1	4
Tyrosinase	0	1	0	1
Carbonic anhydrase	0	0	0	2
Solute carrier family 15 member 1	0	1	0	1
Carbonic anhydrase	0	0	0	2
Large neutral amino acids transporter small subunit 1	0	2	0	2
SLC16A10 protein	0	0	0	2
Carbonic anhydrase	0	0	0	2
Carbonic anhydrase	0	0	0	2
Carbonic anhydrase	0	0	0	2
Carbonic anhydrase	0	0	0	2
Monocarboxylate transporter 10	0	0	0	2
phosphoglycerate kinase	2	0	0	2
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast	0	1	0	1
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast	0	1	0	1
Glutathione reductase, mitochondrial	0	3	0	4
Cationic amino acid transporter 3	0	1	0	1
Cytochrome P450 1A1	0	1	0	1
Cytochrome P450 1A2	0	1	0	1
Myeloperoxidase	0	1	0	1
Cytochrome P450 2C11	0	1	0	1
Ribosyldihydronicotinamide dehydrogenase [quinone]	0	4	1	5
Metabotropic glutamate receptor 1	0	1	0	1
Acetylcholinesterase	0	1	0	1
Mu-type opioid receptor	0	1	0	1
Nociceptin receptor	0	1	0	1
Melatonin receptor type 1A	0	2	1	3
Melatonin receptor type 1C	0	0	1	1
Melatonin receptor type 1A	0	1	1	2
Melatonin receptor type 1B	0	2	1	3
Melatonin receptor type 1C	0	1	1	2
Melatonin receptor type 1B	0	1	1	2
Nuclear factor erythroid 2-related factor 2	0	0	0	1
Carboxylic ester hydrolase	0	1	0	1
Synaptic vesicular amine transporter	0	1	0	1
Trace amine-associated receptor 1	0	0	1	1
Trace amine-associated receptor 1	0	0	1	1
Trace amine-associated receptor 1	0	0	1	1
Trace amine-associated receptor 1	0	0	1	1
Chain E, Fibrin beta chain	0	1	0	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	3	0	0	3
T cell receptor, partial	1	0	0	1
luteinizing hormone receptor	1	0	0	1
chaperonin-containing TCP-1 beta subunit homolog	1	0	0	1
Caspase 6, apoptosis-related cysteine peptidase	0	0	0	1
PPM1D protein	3	0	0	3
TSHR protein	1	0	0	1
Apoptotic peptidase activating factor 1	0	1	0	1
isocitrate dehydrogenase 1, partial	1	0	0	1
luciferase	1	0	0	1
bromodomain adjacent to zinc finger domain 2B	1	0	0	1
serine-protein kinase ATM isoform a	1	0	0	1
neutrophil cytosol factor 1	0	1	0	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	2	0	0	2
caspase-9 isoform alpha precursor	0	1	0	1
huntingtin isoform 2	2	0	0	2
pyruvate kinase PKM isoform a	1	0	0	1
caspase-3 isoform a preproprotein	0	1	0	1
protein AF-9 isoform a	0	0	0	1
Vpr	1	0	0	1
replicative DNA helicase	0	0	0	1
recombinase A	0	0	1	1
DNA repair protein RAD52 homolog isoform a	0	0	0	1
neuropeptide S receptor isoform A	2	0	0	2
Glutathione reductase	0	1	0	1
Glycoprotein hormones alpha chain	1	0	0	1
Albumin	0	0	0	1
Dihydrolipoyl dehydrogenase, mitochondrial	0	1	0	2
Microtubule-associated protein tau	0	1	1	2
Cruzipain	0	1	0	1
Guanine nucleotide-binding protein G	1	0	0	1
Inositol monophosphatase 1	2	0	0	2
TAR DNA-binding protein 43	1	0	0	1
Thioredoxin reductase 1, cytoplasmic	0	1	0	2
Dihydrolipoyl dehydrogenase	0	1	0	2
ATPase family AAA domain-containing protein 5	2	0	0	2
Indoleamine 2,3-dioxygenase 1	0	1	0	1
Chain B, Exotoxin A	0	0	1	1
Chain B, Exotoxin A	0	0	1	1
Chain B, Exotoxin A	0	0	1	1
runt-related transcription factor 1 isoform AML1b	1	0	0	1
core-binding factor subunit beta isoform 2	1	0	0	1
Glutamate receptor 1	1	0	0	1
Glutamate receptor 3	1	0	0	1
Glutamate receptor 4	1	0	0	1
DNA repair protein RAD52 homolog	0	1	0	1
Glutamate receptor 1	0	1	0	1
glucocerebrosidase	2	0	0	2
alpha-galactosidase	2	0	0	2
NPC intracellular cholesterol transporter 1 precursor	2	0	0	2
interferon gamma precursor	0	0	0	1
cytochrome P450 2C9 precursor	2	0	0	2
Alpha-1A adrenergic receptor	0	2	2	4
Beta-casein	0	1	0	1
Interstitial collagenase	0	1	0	1
Matrix metalloproteinase-9	0	1	0	1
Alpha-1A adrenergic receptor	0	2	0	2
Alpha-1B adrenergic receptor	0	2	0	2
Alpha-2A adrenergic receptor	0	1	0	1
Alpha-mannosidase 2C1	0	0	1	1
Bromodomain-containing protein 2	0	2	0	2
5-hydroxytryptamine receptor 1D	0	1	0	1
5-hydroxytryptamine receptor 1B	0	1	0	1
Alpha-2B adrenergic receptor	0	2	0	2
3-oxo-5-alpha-steroid 4-dehydrogenase 2	0	1	0	1
Delta-type opioid receptor	0	1	0	1
Type-1 angiotensin II receptor	0	1	0	1
Alpha-1A adrenergic receptor	0	4	3	11
Alpha-1B adrenergic receptor	0	4	3	9
Alpha-2C adrenergic receptor	0	2	0	2
Alpha-2A adrenergic receptor	0	2	0	2
Alpha-2A adrenergic receptor	0	1	0	1
Multidrug and toxin extrusion protein 2	0	1	0	1
Multidrug and toxin extrusion protein 1	0	1	0	1
Nicotinate phosphoribosyltransferase	0	1	0	1
Amine oxidase [flavin-containing] B	0	1	0	2
NADH-ubiquinone oxidoreductase chain 1	0	1	0	1
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial	0	1	0	1
Dihydroorotate dehydrogenase (fumarate)	0	1	0	1
Acyl carrier protein, mitochondrial	0	1	0	1
Dihydroorotate dehydrogenase	0	1	0	1
Leukotriene C4 synthase	0	0	1	1
Bone morphogenetic protein receptor type-1B	0	0	1	1
Membrane-associated progesterone receptor component 1	0	0	1	1
Cell division cycle 7-related protein kinase	0	0	1	1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	0	0	1	1
Serine/threonine-protein kinase PLK4	0	0	1	1
Serine/threonine-protein kinase 25	0	0	1	1
ATP-dependent RNA helicase DDX3X	0	0	1	1
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta	0	0	1	1
Pyridoxal kinase	0	0	1	1
Citron Rho-interacting kinase	0	0	1	1
Serine/threonine-protein kinase RIO3	0	0	1	1
Dual specificity mitogen-activated protein kinase kinase 7	0	0	1	1
Serine/threonine-protein kinase Chk1	0	0	1	1
Inhibitor of nuclear factor kappa-B kinase subunit beta	0	0	1	1
Peripheral plasma membrane protein CASK	0	0	1	1
Aurora kinase A	0	0	1	1
Cyclin-G-associated kinase	0	0	1	1
Serine/threonine-protein kinase DCLK1	0	0	1	1
Inhibitor of nuclear factor kappa-B kinase subunit alpha	0	0	1	1
Muscle, skeletal receptor tyrosine-protein kinase	0	0	1	1
Ephrin type-B receptor 6	0	0	1	1
Peroxisomal acyl-coenzyme A oxidase 3	0	0	1	1
Mitogen-activated protein kinase 13	0	0	1	1
3-phosphoinositide-dependent protein kinase 1	0	0	1	1
Mitogen-activated protein kinase kinase kinase 13	0	0	1	1
Death-associated protein kinase 3	0	0	1	1
Mitogen-activated protein kinase kinase kinase 7	0	0	1	1
Receptor-interacting serine/threonine-protein kinase 2	0	0	1	1
Mitotic checkpoint serine/threonine-protein kinase BUB1	0	0	1	1
NUAK family SNF1-like kinase 1	0	0	1	1
Dynamin-like 120 kDa protein, mitochondrial	0	0	1	1
Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma	0	0	1	1
Tyrosine-protein kinase JAK2	0	0	1	1
Eukaryotic translation initiation factor 5B	0	0	1	1
Rho-associated protein kinase 2	0	0	1	1
Serine/threonine-protein kinase ULK1	0	0	1	1
Serine/threonine-protein kinase/endoribonuclease IRE1	0	0	1	1
Ribosomal protein S6 kinase alpha-5	0	0	1	1
U5 small nuclear ribonucleoprotein 200 kDa helicase	0	0	1	1
Ribosomal protein S6 kinase alpha-4	0	0	1	1
Serine/threonine-protein kinase 16	0	0	1	1
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	0	0	1	1
Serine/threonine-protein kinase PAK 3	0	0	1	1
Cyclin-dependent kinase-like 5	0	0	1	1
Serine/threonine-protein kinase 17B	0	0	1	1
Serine/threonine-protein kinase 10	0	0	1	1
Serine/threonine-protein kinase D3	0	0	1	1
Cyclin-dependent kinase 14	0	0	1	1
Structural maintenance of chromosomes protein 2	0	0	1	1
Mitogen-activated protein kinase kinase kinase 6	0	0	1	1
Serine/threonine-protein kinase OSR1	0	0	1	1
Mitogen-activated protein kinase kinase kinase kinase 4	0	0	1	1
Serine/threonine-protein kinase LATS1	0	0	1	1
Serine/threonine-protein kinase PAK 4	0	0	1	1
Serine/threonine-protein kinase Chk2	0	0	1	1
Tyrosine-protein kinase ABL1	0	2	1	3
Proto-oncogene tyrosine-protein kinase Src	0	0	1	1
Low-density lipoprotein receptor	0	1	0	1
Fibronectin	0	1	0	1
RAF proto-oncogene serine/threonine-protein kinase	0	1	1	2
High affinity nerve growth factor receptor	0	0	1	1
ADP/ATP translocase 2	0	0	1	1
Protein kinase C beta type	0	0	1	1
Insulin receptor	0	0	1	1
Cyclin-dependent kinase 1	0	0	1	1
Glycogen phosphorylase, liver form	0	0	1	1
Tyrosine-protein kinase Fes/Fps	0	0	1	1
Macrophage colony-stimulating factor 1 receptor	0	1	1	2
Tyrosine-protein kinase Yes	0	0	1	1
Tyrosine-protein kinase Lyn	0	1	1	2
Proto-oncogene tyrosine-protein kinase receptor Ret	0	0	1	1
Insulin-like growth factor 1 receptor	0	0	1	1
Signal recognition particle receptor subunit alpha	0	0	1	1
Cytochrome c1, heme protein, mitochondrial	0	0	1	1
Hepatocyte growth factor receptor	0	0	1	1
Tyrosine-protein kinase HCK	0	1	1	2
Proto-oncogene tyrosine-protein kinase ROS	0	0	1	1
Macrophage colony-stimulating factor 1 receptor	0	1	0	1
Platelet-derived growth factor receptor beta	0	1	1	2
Tyrosine-protein kinase Fgr	0	0	1	1
Wee1-like protein kinase 2	0	0	1	1
Uncharacterized serine/threonine-protein kinase SBK3	0	0	1	1
Serine/threonine-protein kinase A-Raf	0	0	1	1
Mast/stem cell growth factor receptor Kit	0	1	1	2
Glycogen phosphorylase, brain form	0	0	1	1
Breakpoint cluster region protein	0	2	1	3
Serine/threonine-protein kinase pim-1	0	0	1	1
Fibroblast growth factor receptor 1	0	0	1	1
DNA topoisomerase 2-alpha	0	0	1	1
Cyclin-dependent kinase 4	0	0	1	1
ADP/ATP translocase 3	0	0	1	1
Inosine-5'-monophosphate dehydrogenase 2	0	0	1	1
cAMP-dependent protein kinase type II-alpha regulatory subunit	0	0	1	1
Solute carrier family 2, facilitated glucose transporter member 4	0	1	0	1
Insulin receptor-related protein	0	0	1	1
Serine/threonine-protein kinase B-raf	0	0	1	1
Potassium voltage-gated channel subfamily E member 1	0	1	0	1
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform	0	0	1	1
Platelet-derived growth factor receptor alpha	0	1	1	2
Tyrosine-protein kinase Fer	0	0	1	1
Protein kinase C alpha type	0	0	1	1
cAMP-dependent protein kinase catalytic subunit alpha	0	0	1	1
Vascular endothelial growth factor receptor 1	0	0	1	1
General transcription and DNA repair factor IIH helicase subunit XPD	0	0	1	1
Interferon-induced, double-stranded RNA-activated protein kinase	0	0	1	1
Casein kinase II subunit alpha'	0	0	1	1
Ras-related protein Rab-6A	0	0	1	1
Serine/threonine-protein kinase MAK	0	0	1	1
Cyclin-dependent kinase 11B	0	0	1	1
Ephrin type-A receptor 1	0	0	1	1
Fibroblast growth factor receptor 2	0	0	1	1
Multifunctional protein ADE2	0	0	1	1
Fibroblast growth factor receptor 4	0	0	1	1
Fibroblast growth factor receptor 3	0	0	1	1
cAMP-dependent protein kinase catalytic subunit gamma	0	0	1	1
cAMP-dependent protein kinase catalytic subunit beta	0	0	1	1
Ferrochelatase, mitochondrial	0	0	1	1
Ribosomal protein S6 kinase beta-1	0	0	1	1
Tyrosine-protein kinase JAK1	0	0	1	1
Protein kinase C eta type	0	0	1	1
Cyclin-dependent kinase 2	0	0	1	1
Beta-adrenergic receptor kinase 1	0	0	1	1
Probable ATP-dependent RNA helicase DDX6	0	0	1	1
Activin receptor type-2A	0	0	1	1
Mitogen-activated protein kinase 3	0	0	1	1
MAP/microtubule affinity-regulating kinase 3	0	0	1	1
Deoxycytidine kinase	0	0	1	1
Mitogen-activated protein kinase 1	0	0	1	1
Ephrin type-A receptor 2	0	1	1	2
Ephrin type-A receptor 3	0	0	1	1
Ephrin type-A receptor 8	0	0	1	1
Ephrin type-B receptor 2	0	0	1	1
Leukocyte tyrosine kinase receptor	0	0	1	1
Non-receptor tyrosine-protein kinase TYK2	0	0	1	1
UMP-CMP kinase	0	0	1	1
Phosphatidylethanolamine-binding protein 1	0	0	1	1
Wee1-like protein kinase	0	0	1	1
Heme oxygenase 2	0	0	1	1
Tyrosine-protein kinase receptor UFO	0	0	1	1
Mitogen-activated protein kinase 4	0	0	1	1
S-adenosylmethionine synthase isoform type-2	0	0	1	1
DnaJ homolog subfamily A member 1	0	0	1	1
RAC-alpha serine/threonine-protein kinase	0	0	1	1
RAC-beta serine/threonine-protein kinase	0	0	1	1
G protein-coupled receptor kinase 4	0	0	1	1
Dual specificity protein kinase TTK	0	0	1	1
DNA replication licensing factor MCM4	0	0	1	1
Myosin-10	0	0	1	1
Tyrosine-protein kinase receptor Tie-1	0	0	1	1
Vascular endothelial growth factor receptor 3	0	0	1	1
Dual specificity mitogen-activated protein kinase kinase 2	0	0	1	1
Receptor-type tyrosine-protein kinase FLT3	0	1	1	2
Bone morphogenetic protein receptor type-1A	0	0	1	1
Activin receptor type-1B	0	0	1	1
TGF-beta receptor type-1	0	0	1	1
Serine/threonine-protein kinase receptor R3	0	0	1	1
TGF-beta receptor type-2	0	0	1	1
Tyrosine-protein kinase CSK	0	0	1	1
Glycine--tRNA ligase	0	0	1	1
Protein kinase C iota type	0	0	1	1
Exosome RNA helicase MTR4	0	0	1	1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	0	0	1	1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0	0	1	1
Megakaryocyte-associated tyrosine-protein kinase	0	0	1	1
Tyrosine-protein kinase Tec	0	0	1	1
Tyrosine-protein kinase TXK	0	0	1	1
Tyrosine-protein kinase ABL2	0	0	1	1
Tyrosine-protein kinase FRK	0	0	1	1
G protein-coupled receptor kinase 6	0	0	1	1
Tyrosine-protein kinase ZAP-70	0	0	1	1
Tyrosine-protein kinase SYK	0	0	1	1
26S proteasome regulatory subunit 6B	0	0	1	1
Mitogen-activated protein kinase 8	0	0	1	1
Mitogen-activated protein kinase 9	0	0	1	1
Dual specificity mitogen-activated protein kinase kinase 4	0	0	1	1
Dual specificity mitogen-activated protein kinase kinase 3	0	0	1	1
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha	0	0	1	1
Casein kinase I isoform alpha	0	0	1	1
Casein kinase I isoform delta	0	0	1	1
MAP kinase-activated protein kinase 2	0	0	1	1
Cyclin-dependent kinase 8	0	0	1	1
Elongation factor Tu, mitochondrial	0	0	1	1
Cysteine--tRNA ligase, cytoplasmic	0	0	1	1
Casein kinase I isoform epsilon	0	0	1	1
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial	0	0	1	1
Dual specificity protein kinase CLK1	0	0	1	1
Dual specificity protein kinase CLK2	0	0	1	1
Dual specificity protein kinase CLK3	0	0	1	1
Glycogen synthase kinase-3 alpha	0	0	1	1
Glycogen synthase kinase-3 beta	0	0	1	1
Cyclin-dependent kinase 7	0	0	1	1
Cyclin-dependent kinase 9	0	0	1	1
Ras-related protein Rab-27A	0	0	1	1
Tyrosine-protein kinase Blk	0	1	1	2
Interleukin-1 receptor-associated kinase 1	0	0	1	1
Potassium voltage-gated channel subfamily KQT member 1	0	1	0	1
Ribosomal protein S6 kinase alpha-3	0	0	1	1
Cytoplasmic tyrosine-protein kinase BMX	0	0	1	1
cAMP-dependent protein kinase catalytic subunit PRKX	0	0	1	1
Serine/threonine-protein kinase Nek2	0	0	1	1
Serine/threonine-protein kinase Nek3	0	0	1	1
Serine/threonine-protein kinase Nek4	0	0	1	1
Tyrosine-protein kinase JAK3	0	0	1	1
Dual specificity mitogen-activated protein kinase kinase 6	0	0	1	1
Serine/threonine-protein kinase PLK1	0	0	1	1
Death-associated protein kinase 1	0	0	1	1
LIM domain kinase 1	0	0	1	1
LIM domain kinase 2	0	0	1	1
Mitogen-activated protein kinase 12	0	0	1	1
Mitogen-activated protein kinase 10	0	0	1	1
Tyrosine--tRNA ligase, cytoplasmic	0	0	1	1
5'-AMP-activated protein kinase subunit gamma-1	0	0	1	1
5'-AMP-activated protein kinase catalytic subunit alpha-2	0	0	1	1
Ephrin type-B receptor 3	0	0	1	1
Ephrin type-A receptor 5	0	0	1	1
Ephrin type-B receptor 4	0	0	1	1
Ephrin type-B receptor 1	0	0	1	1
Ephrin type-A receptor 4	0	0	1	1
Adenylate kinase 2, mitochondrial	0	0	1	1
Adenosine kinase	0	0	1	1
Hormonally up-regulated neu tumor-associated kinase	0	0	1	1
Serine/threonine-protein kinase SIK1	0	0	1	1
Receptor-interacting serine/threonine-protein kinase 4	0	0	1	1
Ras-related protein Rab-10	0	0	1	1
Cell division control protein 2 homolog	0	0	1	1
Actin-related protein 3	0	0	1	1
Actin-related protein 2	0	0	1	1
Calcium-dependent protein kinase 1	0	0	1	1
GTP-binding nuclear protein Ran	0	0	1	1
Ras-related C3 botulinum toxin substrate 1	0	0	1	1
Casein kinase II subunit alpha	0	0	1	1
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta	0	0	1	1
SRSF protein kinase 2	0	0	1	1
Casein kinase I isoform gamma-2	0	0	1	1
Mitogen-activated protein kinase kinase kinase 9	0	0	1	1
Serine/threonine-protein kinase PknB	0	0	1	1
Cyclin-dependent kinase 3	0	0	1	1
Cyclin-dependent kinase-like 1	0	0	1	1
Cyclin-dependent kinase 6	0	0	1	1
Cyclin-dependent-like kinase 5	0	0	1	1
Cyclin-dependent kinase 16	0	0	1	1
Cyclin-dependent kinase 17	0	0	1	1
ATP-dependent 6-phosphofructokinase, platelet type	0	0	1	1
Protein kinase C epsilon type	0	0	1	1
Dual specificity mitogen-activated protein kinase kinase 1	0	0	1	1
Angiopoietin-1 receptor	0	0	1	1
Mitogen-activated protein kinase kinase kinase 10	0	0	1	1
DNA topoisomerase 2-beta	0	0	1	1
Protein kinase C theta type	0	0	1	1
Activin receptor type-1	0	0	1	1
Macrophage-stimulating protein receptor	0	0	1	1
Focal adhesion kinase 1	0	0	1	1
Protein kinase C zeta type	0	0	1	1
Protein kinase C delta type	0	0	1	1
Tyrosine-protein kinase BTK	0	0	1	1
Tyrosine-protein kinase receptor TYRO3	0	0	1	1
Cyclin-dependent kinase 18	0	0	1	1
Activated CDC42 kinase 1	0	0	1	1
Epithelial discoidin domain-containing receptor 1	0	2	1	3
Tyrosine-protein kinase ITK/TSK	0	0	1	1
Myotonin-protein kinase	0	0	1	1
Mitogen-activated protein kinase kinase kinase kinase 2	0	0	1	1
Mitogen-activated protein kinase kinase kinase 12	0	0	1	1
Tyrosine-protein kinase Mer	0	0	1	1
Serine/threonine-protein kinase 4	0	0	1	1
5'-AMP-activated protein kinase catalytic subunit alpha-1	0	0	1	1
Serine/threonine-protein kinase PAK 1	0	0	1	1
Dual specificity mitogen-activated protein kinase kinase 5	0	0	1	1
Mitogen-activated protein kinase 7	0	0	1	1
Serine/threonine-protein kinase PAK 2	0	0	1	1
Serine/threonine-protein kinase 3	0	0	1	1
Mitogen-activated protein kinase kinase kinase 1	0	0	1	1
cGMP-dependent protein kinase 2	0	0	1	1
Integrin-linked protein kinase	0	0	1	1
Rho-associated protein kinase 1	0	0	1	1
Non-receptor tyrosine-protein kinase TNK1	0	0	1	1
Serine/threonine-protein kinase PRP4 homolog	0	0	1	1
Receptor-interacting serine/threonine-protein kinase 1	0	0	1	1
Calcium/calmodulin-dependent protein kinase type II subunit beta	0	0	1	1
Calcium/calmodulin-dependent protein kinase type II subunit gamma	0	0	1	1
Calcium/calmodulin-dependent protein kinase type II subunit delta	0	0	1	1
Dual specificity tyrosine-phosphorylation-regulated kinase 1A	0	0	1	1
Activin receptor type-2B	0	0	1	1
Bone morphogenetic protein receptor type-2	0	0	1	1
Protein-tyrosine kinase 6	0	0	1	1
cGMP-dependent protein kinase 1	0	0	1	1
Cyclin-dependent kinase 13	0	0	1	1
Calcium/calmodulin-dependent protein kinase type 1	0	0	1	1
Inhibitor of nuclear factor kappa-B kinase subunit epsilon	0	0	1	1
Protein-tyrosine kinase 2-beta	0	0	1	1
Maternal embryonic leucine zipper kinase	0	0	1	1
Structural maintenance of chromosomes protein 1A	0	0	1	1
Chromodomain-helicase-DNA-binding protein 4	0	0	1	1
Serine/threonine-protein kinase D1	0	0	1	1
Serine/threonine-protein kinase 38	0	0	1	1
Ribosomal protein S6 kinase alpha-2	0	0	1	1
Ephrin type-A receptor 7	0	0	1	1
Delta(24)-sterol reductase	0	0	1	1
Ribosomal protein S6 kinase alpha-1	0	0	1	1
Dual specificity testis-specific protein kinase 1	0	0	1	1
Myosin light chain kinase, smooth muscle	0	0	1	1
Mitogen-activated protein kinase 11	0	0	1	1
Serine/threonine-protein kinase STK11	0	0	1	1
Rhodopsin kinase GRK1	0	0	1	1
NT-3 growth factor receptor	0	0	1	1
Serine/threonine-protein kinase N1	0	0	1	1
Serine/threonine-protein kinase N2	0	0	1	1
Calcium/calmodulin-dependent protein kinase type IV	0	0	1	1
Mitogen-activated protein kinase kinase kinase 11	0	0	1	1
BDNF/NT-3 growth factors receptor	0	0	1	1
Mitogen-activated protein kinase 6	0	0	1	1
Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform	0	0	1	1
Discoidin domain-containing receptor 2	0	2	1	3
AP2-associated protein kinase 1	0	0	1	1
Myosin light chain kinase 3	0	0	1	1
Serine/threonine-protein kinase SBK1	0	0	1	1
Mitogen-activated protein kinase kinase kinase 19	0	0	1	1
Putative heat shock protein HSP 90-beta 2	0	0	1	1
Serine/threonine-protein kinase TNNI3K	0	0	1	1
Rab-like protein 3	0	0	1	1
Leucine-rich repeat serine/threonine-protein kinase 2	0	0	1	1
Serine/threonine-protein kinase MRCK alpha	0	0	1	1
Serine/threonine-protein kinase MRCK gamma	0	0	1	1
Acyl-CoA dehydrogenase family member 10	0	0	1	1
Serine/threonine-protein kinase Nek5	0	0	1	1
Serine/threonine-protein kinase N3	0	0	1	1
Serine/threonine-protein kinase ULK3	0	0	1	1
Dual serine/threonine and tyrosine protein kinase	0	0	1	1
Mitogen-activated protein kinase kinase kinase 15	0	0	1	1
Uncharacterized protein FLJ45252	0	0	1	1
Acyl-CoA dehydrogenase family member 11	0	0	1	1
Serine/threonine-protein kinase/endoribonuclease IRE2	0	0	1	1
Serine/threonine-protein kinase MARK2	0	0	1	1
ATP-dependent RNA helicase DHX30	0	0	1	1
Serine/threonine-protein kinase TAO1	0	0	1	1
STE20-related kinase adapter protein alpha	0	0	1	1
Myosin-14	0	0	1	1
AarF domain-containing protein kinase 1	0	0	1	1
Serine/threonine-protein kinase tousled-like 2	0	0	1	1
Serine/threonine-protein kinase 32C	0	0	1	1
Serine/threonine-protein kinase pim-3	0	0	1	1
Serine/threonine-protein kinase VRK2	0	0	1	1
Myosin light chain kinase family member 4	0	0	1	1
Homeodomain-interacting protein kinase 1	0	0	1	1
Multidrug resistance-associated protein 1	0	1	0	1
Calcium/calmodulin-dependent protein kinase type 1D	0	0	1	1
Mitogen-activated protein kinase kinase kinase kinase 3	0	0	1	1
Cyclin-dependent kinase-like 3	0	0	1	1
MAP kinase-activated protein kinase 5	0	0	1	1
Serine/threonine-protein kinase BRSK2	0	0	1	1
Serine/threonine-protein kinase NIM1	0	0	1	1
Serine/threonine-protein kinase ULK2	0	0	1	1
Misshapen-like kinase 1	0	0	1	1
Serine/threonine-protein kinase DCLK2	0	0	1	1
Calcium/calmodulin-dependent protein kinase kinase 1	0	0	1	1
Casein kinase I isoform alpha-like	0	0	1	1
Proprotein convertase subtilisin/kexin type 9	0	1	0	1
Homeodomain-interacting protein kinase 4	0	0	1	1
Myosin-IIIa	0	0	1	1
Ankyrin repeat and protein kinase domain-containing protein 1	0	0	1	1
Serine/threonine-protein kinase Nek11	0	0	1	1
Atypical kinase COQ8A, mitochondrial	0	0	1	1
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma	0	0	1	1
Mitogen-activated protein kinase 15	0	0	1	1
Serine/threonine-protein kinase Nek9	0	0	1	1
Serine/threonine-protein kinase BRSK1	0	0	1	1
Serine/threonine-protein kinase 35	0	0	1	1
Serine/threonine-protein kinase Nek7	0	0	1	1
Rhodopsin kinase GRK7	0	0	1	1
Serine/threonine-protein kinase 32A	0	0	1	1
Myosin-IIIb	0	0	1	1
ATP-dependent RNA helicase DDX1	0	0	1	1
Dual specificity tyrosine-phosphorylation-regulated kinase 2	0	0	1	1
Cyclin-dependent kinase-like 2	0	0	1	1
Mitogen-activated protein kinase kinase kinase kinase 1	0	0	1	1
Serine/threonine-protein kinase Sgk3	0	0	1	1
Atypical kinase COQ8B, mitochondrial	0	0	1	1
MAP/microtubule affinity-regulating kinase 4	0	0	1	1
Calcium/calmodulin-dependent protein kinase type 1G	0	0	1	1
Serine/threonine-protein kinase Nek1	0	0	1	1
Cyclin-dependent kinase 15	0	0	1	1
PAS domain-containing serine/threonine-protein kinase	0	0	1	1
Calcium/calmodulin-dependent protein kinase kinase 2	0	0	1	1
EKC/KEOPS complex subunit TP53RK	0	0	1	1
Dual specificity testis-specific protein kinase 2	0	0	1	1
SRSF protein kinase 1	0	0	1	1
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	0	0	1	1
Mitogen-activated protein kinase kinase kinase 5	0	0	1	1
Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha	0	0	1	1
Mitogen-activated protein kinase kinase kinase 3	0	0	1	1
Eukaryotic translation initiation factor 2-alpha kinase 1	0	0	1	1
Serine/threonine-protein kinase RIO1	0	0	1	1
MAP kinase-interacting serine/threonine-protein kinase 1	0	0	1	1
Serine/threonine-protein kinase RIO2	0	0	1	1
Cyclin-dependent kinase 19	0	0	1	1
Transient receptor potential cation channel subfamily M member 6	0	0	1	1
Testis-specific serine/threonine-protein kinase 1	0	0	1	1
Serine/threonine-protein kinase 33	0	0	1	1
Nucleolar GTP-binding protein 1	0	0	1	1
Serine/threonine-protein kinase D2	0	0	1	1
Serine/threonine-protein kinase DCLK3	0	0	1	1
NUAK family SNF1-like kinase 2	0	0	1	1
RNA cytidine acetyltransferase	0	0	1	1
Serine/threonine-protein kinase SIK2	0	0	1	1
Myosin light chain kinase 2, skeletal/cardiac muscle	0	0	1	1
STE20-like serine/threonine-protein kinase	0	0	1	1
Serine/threonine-protein kinase TAO3	0	0	1	1
Homeodomain-interacting protein kinase 2	0	0	1	1
Tyrosine-protein kinase Srms	0	0	1	1
Homeodomain-interacting protein kinase 3	0	0	1	1
Serine/threonine-protein kinase PLK3	0	0	1	1
dCTP pyrophosphatase 1	0	0	1	1
Dual specificity protein kinase CLK4	0	0	1	1
MAP kinase-interacting serine/threonine-protein kinase 2	0	0	1	1
Serine/threonine-protein kinase Nek6	0	0	1	1
Casein kinase I isoform gamma-1	0	0	1	1
Serine/threonine-protein kinase PAK 6	0	0	1	1
SNF-related serine/threonine-protein kinase	0	0	1	1
Serine/threonine-protein kinase LATS2	0	0	1	1
Serine/threonine-protein kinase 36	0	0	1	1
Phenylalanine--tRNA ligase beta subunit	0	0	1	1
Isoleucine--tRNA ligase, mitochondrial	0	0	1	1
BMP-2-inducible protein kinase	0	0	1	1
Obg-like ATPase 1	0	0	1	1
Midasin	0	0	1	1
Interleukin-1 receptor-associated kinase 4	0	0	1	1
Serine/threonine-protein kinase 32B	0	0	1	1
Mitogen-activated protein kinase kinase kinase 20	0	0	1	1
Cyclin-dependent kinase 12	0	0	1	1
Serine/threonine-protein kinase PLK2	0	0	1	1
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13	0	0	1	1
Serine/threonine-protein kinase MARK1	0	0	1	1
Serine/threonine-protein kinase pim-2	0	0	1	1
Serine/threonine-protein kinase PAK 5	0	0	1	1
Serine/threonine-protein kinase 26	0	0	1	1
eIF-2-alpha kinase GCN2	0	0	1	1
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial	0	0	1	1
Serine/threonine-protein kinase NLK	0	0	1	1
Phosphatidylinositol 4-kinase beta	0	0	1	1
Serine/threonine-protein kinase 17A	0	0	1	1
STE20/SPS1-related proline-alanine-rich protein kinase	0	0	1	1
Ephrin type-A receptor 6	0	0	1	1
5'-AMP-activated protein kinase subunit gamma-2	0	0	1	1
Serine/threonine-protein kinase TBK1	0	0	1	1
Septin-9	0	0	1	1
Death-associated protein kinase 2	0	0	1	1
Potassium voltage-gated channel subfamily D member 3	0	1	0	1
Ribosomal protein S6 kinase alpha-6	0	0	1	1
TRAF2 and NCK-interacting protein kinase	0	0	1	1
Serine/threonine-protein kinase tousled-like 1	0	0	1	1
Serine/threonine-protein kinase TAO2	0	0	1	1
ALK tyrosine kinase receptor	0	0	1	1
SRSF protein kinase 3	0	0	1	1
Serine/threonine-protein kinase ICK	0	0	1	1
Cyclin-dependent kinase 11A	0	0	1	1
Aurora kinase C	0	0	1	1
Calcium/calmodulin-dependent protein kinase type II subunit alpha	0	0	1	1
RAC-gamma serine/threonine-protein kinase	0	0	1	1
Serine/threonine-protein kinase 38-like	0	0	1	1
Microtubule-associated serine/threonine-protein kinase 1	0	0	1	1
Serine/threonine-protein kinase SIK3	0	0	1	1
Mitogen-activated protein kinase kinase kinase 2	0	0	1	1
Thyroid hormone receptor-associated protein 3	0	0	1	1
Dual specificity tyrosine-phosphorylation-regulated kinase 1B	0	0	1	1
Mitogen-activated protein kinase kinase kinase kinase 5	0	0	1	1
Receptor-interacting serine/threonine-protein kinase 3	0	0	1	1
Serine/threonine-protein kinase MRCK beta	0	0	1	1
Interleukin-1 receptor-associated kinase 3	0	0	1	1
Serine/threonine-protein kinase 24	0	0	1	1
Casein kinase I isoform gamma-3	0	0	1	1
Mitogen-activated protein kinase kinase kinase 4	0	0	1	1
Lysine-specific histone demethylase 1A	0	1	0	1
P2Y purinoceptor 12	0	1	0	1
Acetylcholinesterase	0	2	0	2
Cytochrome P450 2B1	0	1	0	1
Amine oxidase [flavin-containing] A	0	2	0	2
Type-1 angiotensin II receptor	0	1	0	1
C-X-C chemokine receptor type 3	0	1	0	1
Sigma intracellular receptor 2	0	1	0	1
Amine oxidase [flavin-containing] A	0	0	0	1
Cholinesterase	0	1	0	1
Proton-coupled amino acid transporter 1	0	1	0	1
Chain A, CHORISMATE MUTASE	0	1	0	1
Chain A, TYROSYL-tRNA SYNTHETASE	0	0	1	1
Tubulin--tyrosine ligase	0	1	0	1
Taste receptor type 2 member 14	0	0	0	1
Solute carrier family 22 member 6	0	0	0	1
Solute carrier family 22 member 8	0	1	0	1
Solute carrier family 2, facilitated glucose transporter member 9	0	1	1	2
Proprotein convertase subtilisin/kexin type 7	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	1	0	1
Protease	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	2	0	2
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(4)

Research Excerpts

Overview

Treatment

Research

Studies (446)

Protein Targets (1,231)

a-Synucleinopathies

Synonyms(4)

Research Excerpts

Overview

Treatment

Research

Studies (446)

Drugs Studied (102)

Protein Targets (1,231)