Page last updated: 2024-09-28

Chilblains

Recurrent localized itching, swelling and painful erythema on the fingers, toes or ears, produced by exposure to cold.

Synonyms(4)

Synonym
Chilblains
Pernio
Idiopathic Perniosis
Perniosis

Research Excerpts

Overview

Excerpt	Reference
"Forty patients with perniosis were enrolled in this study, and divided randomly into 2 equal groups, according to the sort of treatment."	( Fadheel, BM; Noaimi, AA, 2008)
"Chronic chilblains is a common disease causing major restrictions in daily life, nevertheless little is known about effective treatment."	( Lagro-Janssen, AL; Souwer, IH, 2009)
"Primary perniosis is an annoying cold-induced dermatosis."	( Al-Sudany, NK, 2016)
"One is perniosis occurring in mildly symptomatic patients, typically children and young adults; the second is the thrombotic retiform purpura of critically ill adults with COVID-19."	( Crowson, AN; Grossman, M; Harp, J; Laurence, J; Magro, CM; Mulvey, JJ; Nuovo, G; Sanders, S, 2021)
"COVID-19-associated perniosis represents a virally triggered exaggerated immune reaction with significant type I interferon signaling."	( Crowson, AN; Grossman, M; Harp, J; Laurence, J; Magro, CM; Mulvey, JJ; Nuovo, G; Sanders, S, 2021)
"Idiopathic chilblains is a cold-induced inflammatory condition that causes significant morbidity."	( Kirchhof, MG; Mahmood, F; Pratt, M, 2021)

Treatment

Excerpt	Reference
"She was diagnosed with pernio and successfully treated, initially with nifedipine and subsequently with management of the affected area's environment."	( Parlette, EC; Parlette, HL, 2000)
"Forty patients with perniosis were enrolled in this study, and divided randomly into 2 equal groups, according to the sort of treatment."	( Fadheel, BM; Noaimi, AA, 2008)
"To determine outcomes of patients with perniosis treated with hydroxychloroquine."	( English, JC; Perez, OA; Yang, X, 2010)

Research

Studies (92)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	34 (36.96)	23.3326
1990's	4 (4.35)	12.5806
2000's	14 (15.22)	18.1394
2010's	24 (26.09)	28.8240
2020's	16 (17.39)	9.53

Drug	Relationship Strength	Studies	Trials
quinacrine	low	2	0
dalteparin	low	1	0
iodine	low	1	0
niacinamide	low	1	0
niacin	low	2	0
altretamine	low	1	0
chloroquine	low	1	0
cilostazol	low	2	0
dapsone	low	1	0
hydroxychloroquine	low	13	0
nifedipine	medium	8	3
nitroglycerin	low	1	0
pentoxifylline	medium	3	2
phenoxybenzamine	low	2	0
procaine	low	1	0
thalidomide	low	1	0
prednisolone	medium	4	1
reserpine	low	1	0
aspartic acid	low	1	0
fluocinolone acetonide	low	2	0
triamcinolone acetonide	low	1	0
methylprednisolone	low	3	0
pyrroles	low	1	0
ergotamine	low	1	0
betamethasone	medium	3	1
d-alpha tocopherol	low	2	0
trolamine salicylate	low	1	0
phenyl acetate	low	1	0
triamcinolone	low	2	0
docetaxel anhydrous	low	1	0
lenalidomide	low	1	0
mometasone furoate	low	1	0
cocaine	low	1	0
mycophenolic acid	low	2	0
bromochloroacetic acid	low	1	0
cinnarizine	low	1	0
sulindac	low	1	0
naphthoquinones	low	3	0
vitamin k semiquinone radical	low	5	0
vitamin d 2	low	6	0
cholecalciferol	medium	2	1
phenylephrine hydrochloride	low	2	0
clobetasol	medium	4	1
arsenic	low	1	0
tofacitinib	low	2	0
tannins	low	1	0
baricitinib	low	2	0
piperidines	low	2	0
cyclosporine	low	1	0

Protein Targets (1,074)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	9	0	0	9
Chain A, HADH2 protein	7	0	0	7
Chain B, HADH2 protein	7	0	0	7
thioredoxin reductase	14	0	0	14
TDP1 protein	20	0	0	20
GLI family zinc finger 3	18	0	0	18
AR protein	25	0	0	25
progesterone receptor	13	0	0	13
regulator of G-protein signaling 4	6	0	0	6
EWS/FLI fusion protein	9	0	0	9
nonstructural protein 1	4	0	0	4
estrogen nuclear receptor alpha	25	0	0	25
arylsulfatase A	8	0	0	8
alpha-galactosidase	2	0	0	2
euchromatic histone-lysine N-methyltransferase 2	22	0	0	22
Bloom syndrome protein isoform 1	9	0	0	9
D(1A) dopamine receptor	3	0	0	3
thyroid hormone receptor beta isoform a	5	0	0	5
fMet-Leu-Phe receptor	0	1	0	1
importin subunit beta-1 isoform 1	4	0	0	4
snurportin-1	4	0	0	4
GTP-binding nuclear protein Ran isoform 1	4	0	0	4
histone acetyltransferase KAT2A isoform 1	8	0	0	8
muscarinic acetylcholine receptor M1	7	0	0	7
lamin isoform A-delta10	17	0	0	17
Bile salt export pump	0	23	0	23
Cytochrome P450 1A2	0	2	0	2
CREB-binding protein	1	0	0	1
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	3	0	0	3
Chain A, Ferritin light chain	3	0	0	3
phosphopantetheinyl transferase	3	0	0	3
aldehyde dehydrogenase 1 family, member A1	13	0	0	13
cytochrome P450 2C19 precursor	3	0	0	3
lethal factor (plasmid)	4	0	0	4
Metabotropic glutamate receptor 6	0	0	1	1
Excitatory amino acid transporter 4	0	1	0	1
Glutamate transporter homolog	0	0	1	1
Carbonic anhydrase 1	0	0	0	1
Carbonic anhydrase 2	0	0	0	1
N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase	0	1	0	1
5-hydroxytryptamine receptor 1D	0	2	0	3
Glutamate receptor ionotropic, NMDA 1	0	2	0	2
Excitatory amino acid transporter 1	0	1	0	1
Excitatory amino acid transporter 2	0	1	0	1
Excitatory amino acid transporter 3	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	2	0	2
Glutamate receptor ionotropic, NMDA 2B	0	3	0	3
Glutamate receptor ionotropic, NMDA 2C	0	2	0	2
Metabotropic glutamate receptor 1	0	0	1	1
Metabotropic glutamate receptor 2	0	0	1	1
Carbonic anhydrase-like protein, putative	0	0	0	1
Glutamate receptor ionotropic, NMDA 2D	0	2	0	2
Glutamate receptor ionotropic, NMDA 3B	0	2	0	2
Carbonic anhydrase 4	0	0	0	1
Glutamate receptor ionotropic, NMDA 3A	0	2	0	2
PPM1D protein	5	0	0	5
Bone morphogenetic protein receptor type-1B	0	0	2	2
Membrane-associated progesterone receptor component 1	0	0	2	2
Serine/threonine-protein kinase PLK4	0	0	2	2
ATP-dependent RNA helicase DDX3X	0	0	2	2
Pyridoxal kinase	0	0	2	2
Citron Rho-interacting kinase	0	0	2	2
Serine/threonine-protein kinase Chk1	0	1	2	3
Aurora kinase A	0	0	2	2
Cyclin-G-associated kinase	0	1	2	3
Ephrin type-B receptor 6	0	0	2	2
Peroxisomal acyl-coenzyme A oxidase 3	0	0	2	2
Receptor-interacting serine/threonine-protein kinase 2	0	0	2	2
Dynamin-like 120 kDa protein, mitochondrial	0	0	2	2
Tyrosine-protein kinase JAK2	0	4	2	9
Eukaryotic translation initiation factor 5B	0	0	1	1
Rho-associated protein kinase 2	0	1	2	3
Serine/threonine-protein kinase ULK1	0	0	2	2
Serine/threonine-protein kinase/endoribonuclease IRE1	0	0	2	2
Ribosomal protein S6 kinase alpha-5	0	1	2	3
U5 small nuclear ribonucleoprotein 200 kDa helicase	0	0	2	2
Ribosomal protein S6 kinase alpha-4	0	0	2	2
Serine/threonine-protein kinase 16	0	0	2	2
Serine/threonine-protein kinase 10	0	0	2	2
Serine/threonine-protein kinase D3	0	0	2	2
Structural maintenance of chromosomes protein 2	0	0	1	1
Mitogen-activated protein kinase kinase kinase 6	0	0	2	2
Mitogen-activated protein kinase kinase kinase kinase 4	0	0	2	2
Serine/threonine-protein kinase LATS1	0	0	2	2
Serine/threonine-protein kinase PAK 4	0	0	2	2
Tyrosine-protein kinase ABL1	0	0	2	3
Epidermal growth factor receptor	0	2	2	4
Interferon beta	16	0	0	16
Guanine nucleotide-binding protein G(i) subunit alpha-2	0	0	1	1
ADP/ATP translocase 2	0	0	2	2
Protein kinase C beta type	0	0	2	2
Insulin receptor	0	1	2	3
Tyrosine-protein kinase Lck	0	2	2	4
Tyrosine-protein kinase Fyn	0	1	2	3
Cyclin-dependent kinase 1	0	0	2	2
Glycogen phosphorylase, liver form	0	0	2	2
Tyrosine-protein kinase Fes/Fps	0	0	2	2
Adenine phosphoribosyltransferase	0	0	1	1
Tyrosine-protein kinase Yes	0	0	2	2
Tyrosine-protein kinase Lyn	0	0	2	2
Proto-oncogene tyrosine-protein kinase receptor Ret	0	0	2	2
Insulin-like growth factor 1 receptor	0	0	2	2
Signal recognition particle receptor subunit alpha	0	0	2	2
Cytochrome c1, heme protein, mitochondrial	0	0	2	2
Hepatocyte growth factor receptor	0	0	2	2
Tyrosine-protein kinase HCK	0	0	2	2
Platelet-derived growth factor receptor beta	0	0	2	2
Serine/threonine-protein kinase A-Raf	0	0	2	2
Glycogen phosphorylase, brain form	0	0	2	2
Breakpoint cluster region protein	0	0	2	3
Serine/threonine-protein kinase pim-1	0	0	2	2
Fibroblast growth factor receptor 1	0	0	2	2
DNA topoisomerase 2-alpha	0	0	2	2
Cyclin-dependent kinase 4	0	0	2	2
ADP/ATP translocase 3	0	0	2	2
Inosine-5'-monophosphate dehydrogenase 2	0	2	1	3
Proto-oncogene tyrosine-protein kinase Src	0	0	2	2
cAMP-dependent protein kinase type II-alpha regulatory subunit	0	0	1	1
Serine/threonine-protein kinase B-raf	0	0	2	2
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform	0	0	2	2
Ribosyldihydronicotinamide dehydrogenase [quinone]	0	2	2	4
Tyrosine-protein kinase Fer	0	0	2	2
Protein kinase C alpha type	0	1	2	3
cAMP-dependent protein kinase catalytic subunit alpha	0	0	2	2
General transcription and DNA repair factor IIH helicase subunit XPD	0	0	2	2
Casein kinase II subunit alpha'	0	0	2	2
Ras-related protein Rab-6A	0	0	2	2
Ephrin type-A receptor 1	0	0	2	2
Multifunctional protein ADE2	0	0	2	2
cAMP-dependent protein kinase catalytic subunit gamma	0	0	2	2
cAMP-dependent protein kinase catalytic subunit beta	0	0	2	2
Ferrochelatase, mitochondrial	0	0	2	2
Ribosomal protein S6 kinase beta-1	0	1	2	3
Tyrosine-protein kinase JAK1	0	4	3	10
Cyclin-dependent kinase 2	0	1	2	3
Beta-adrenergic receptor kinase 1	0	0	2	2
Probable ATP-dependent RNA helicase DDX6	0	0	2	2
Mitogen-activated protein kinase 3	0	0	2	2
MAP/microtubule affinity-regulating kinase 3	0	0	2	2
Deoxycytidine kinase	0	0	2	2
Mitogen-activated protein kinase 1	0	0	2	2
Ephrin type-A receptor 2	0	0	2	2
Ephrin type-B receptor 2	0	0	2	2
Non-receptor tyrosine-protein kinase TYK2	0	4	3	10
UMP-CMP kinase	0	0	1	1
Phosphatidylethanolamine-binding protein 1	0	0	1	1
Wee1-like protein kinase	0	0	2	2
Heme oxygenase 2	0	0	2	2
S-adenosylmethionine synthase isoform type-2	0	0	2	2
DnaJ homolog subfamily A member 1	0	0	2	2
RAC-alpha serine/threonine-protein kinase	0	1	2	3
RAC-beta serine/threonine-protein kinase	0	0	2	2
DNA replication licensing factor MCM4	0	0	1	1
Myosin-10	0	0	1	1
Dual specificity mitogen-activated protein kinase kinase 2	0	0	2	2
Receptor-type tyrosine-protein kinase FLT3	0	0	2	2
Bone morphogenetic protein receptor type-1A	0	0	2	2
Activin receptor type-1B	0	0	2	2
TGF-beta receptor type-1	0	0	2	2
Serine/threonine-protein kinase receptor R3	0	0	2	2
TGF-beta receptor type-2	0	0	2	2
Electron transfer flavoprotein subunit beta	0	0	1	1
Tyrosine-protein kinase CSK	0	1	2	3
Glycine--tRNA ligase	0	0	2	2
Protein kinase C iota type	0	0	2	2
Exosome RNA helicase MTR4	0	0	2	2
Tyrosine-protein kinase Tec	0	1	2	3
Tyrosine-protein kinase ABL2	0	0	2	2
Tyrosine-protein kinase FRK	0	0	2	2
G protein-coupled receptor kinase 6	0	0	1	1
Tyrosine-protein kinase SYK	0	0	2	2
26S proteasome regulatory subunit 6B	0	0	2	2
Mitogen-activated protein kinase 8	0	1	2	3
Mitogen-activated protein kinase 9	0	0	2	2
Dual specificity mitogen-activated protein kinase kinase 3	0	0	2	2
Casein kinase I isoform alpha	0	0	2	2
Casein kinase I isoform delta	0	0	2	2
MAP kinase-activated protein kinase 2	0	1	2	3
Elongation factor Tu, mitochondrial	0	0	2	2
Cysteine--tRNA ligase, cytoplasmic	0	0	2	2
Casein kinase I isoform epsilon	0	0	2	2
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial	0	0	2	2
Dual specificity protein kinase CLK1	0	0	2	2
Dual specificity protein kinase CLK2	0	0	2	2
Dual specificity protein kinase CLK3	0	0	2	2
Glycogen synthase kinase-3 alpha	0	0	2	2
Glycogen synthase kinase-3 beta	0	1	2	3
Cyclin-dependent kinase 7	0	0	2	2
Cyclin-dependent kinase 9	0	0	2	2
Ras-related protein Rab-27A	0	0	1	1
Interleukin-1 receptor-associated kinase 1	0	0	2	2
Ribosomal protein S6 kinase alpha-3	0	1	2	3
Serine/threonine-protein kinase Nek2	0	0	2	2
Serine/threonine-protein kinase Nek3	0	0	2	2
Tyrosine-protein kinase JAK3	0	4	2	10
Dual specificity mitogen-activated protein kinase kinase 6	0	0	2	2
LIM domain kinase 1	0	0	2	2
LIM domain kinase 2	0	0	2	2
Mitogen-activated protein kinase 10	0	0	2	2
Tyrosine--tRNA ligase, cytoplasmic	0	0	2	2
5'-AMP-activated protein kinase subunit gamma-1	0	0	2	2
Ephrin type-B receptor 3	0	0	2	2
Ephrin type-A receptor 5	0	0	2	2
Ephrin type-B receptor 4	0	0	2	2
Ephrin type-A receptor 4	0	0	2	2
Adenylate kinase 2, mitochondrial	0	0	2	2
Adenosine kinase	0	0	2	2
Ras-related protein Rab-10	0	0	2	2
Actin-related protein 3	0	0	2	2
Actin-related protein 2	0	0	1	1
GTP-binding nuclear protein Ran	0	0	2	2
Casein kinase I isoform gamma-2	0	0	2	2
Cyclin-dependent kinase 3	0	0	2	2
Cyclin-dependent kinase 6	0	0	2	2
Cyclin-dependent-like kinase 5	0	1	2	3
Cyclin-dependent kinase 16	0	0	2	2
Cyclin-dependent kinase 17	0	0	2	2
ATP-dependent 6-phosphofructokinase, platelet type	0	0	2	2
Dual specificity mitogen-activated protein kinase kinase 1	0	0	2	2
DNA topoisomerase 2-beta	0	0	2	2
Protein kinase C theta type	0	0	2	2
Activin receptor type-1	0	0	2	2
Macrophage-stimulating protein receptor	0	0	2	2
Focal adhesion kinase 1	0	0	2	2
Protein kinase C delta type	0	0	2	2
Tyrosine-protein kinase BTK	0	1	2	3
Activated CDC42 kinase 1	0	0	2	2
Epithelial discoidin domain-containing receptor 1	0	0	2	2
Mitogen-activated protein kinase kinase kinase kinase 2	0	0	2	2
Serine/threonine-protein kinase 4	0	0	2	2
5'-AMP-activated protein kinase catalytic subunit alpha-1	0	0	2	2
Dual specificity mitogen-activated protein kinase kinase 5	0	0	2	2
Mitogen-activated protein kinase 7	0	0	2	2
Serine/threonine-protein kinase PAK 2	0	0	2	2
Serine/threonine-protein kinase 3	0	0	2	2
Mitogen-activated protein kinase kinase kinase 1	0	0	2	2
Integrin-linked protein kinase	0	0	2	2
Rho-associated protein kinase 1	0	0	2	2
Non-receptor tyrosine-protein kinase TNK1	0	0	2	2
Serine/threonine-protein kinase ATR	0	0	2	2
Calcium/calmodulin-dependent protein kinase type II subunit gamma	0	0	2	2
Calcium/calmodulin-dependent protein kinase type II subunit delta	0	0	2	2
Dual specificity tyrosine-phosphorylation-regulated kinase 1A	0	0	2	2
Activin receptor type-2B	0	0	2	2
Bone morphogenetic protein receptor type-2	0	0	2	2
Protein-tyrosine kinase 6	0	0	2	2
cGMP-dependent protein kinase 1	0	0	2	2
Cyclin-dependent kinase 13	0	0	2	2
Inhibitor of nuclear factor kappa-B kinase subunit epsilon	0	0	2	2
Protein-tyrosine kinase 2-beta	0	0	2	2
Maternal embryonic leucine zipper kinase	0	0	2	2
Structural maintenance of chromosomes protein 1A	0	0	1	1
Chromodomain-helicase-DNA-binding protein 4	0	0	2	2
Peroxisomal acyl-coenzyme A oxidase 1	0	0	1	1
Ephrin type-A receptor 7	0	0	2	2
Delta(24)-sterol reductase	0	0	1	1
Ribosomal protein S6 kinase alpha-1	0	0	2	2
Dual specificity testis-specific protein kinase 1	0	0	2	2
Myosin light chain kinase, smooth muscle	0	1	2	3
Mitogen-activated protein kinase 11	0	1	2	3
Serine/threonine-protein kinase STK11	0	0	2	2
Serine/threonine-protein kinase N1	0	0	2	2
Serine/threonine-protein kinase N2	0	0	2	2
Mitogen-activated protein kinase 14	0	1	2	3
Calcium/calmodulin-dependent protein kinase type IV	0	0	2	2
Mitogen-activated protein kinase kinase kinase 11	0	0	2	2
MAP kinase-activated protein kinase 3	0	0	1	1
Discoidin domain-containing receptor 2	0	0	2	2
AP2-associated protein kinase 1	0	1	2	3
Myosin light chain kinase 3	0	0	2	2
Uncharacterized aarF domain-containing protein kinase 5	0	0	2	2
Putative heat shock protein HSP 90-beta 2	0	0	2	2
Rab-like protein 3	0	0	2	2
Serine/threonine-protein kinase MRCK alpha	0	0	2	2
Serine/threonine-protein kinase MRCK gamma	0	0	2	2
Acyl-CoA dehydrogenase family member 10	0	0	2	2
Serine/threonine-protein kinase ULK3	0	0	2	2
Uncharacterized protein FLJ45252	0	0	2	2
Acyl-CoA dehydrogenase family member 11	0	0	1	1
Serine/threonine-protein kinase/endoribonuclease IRE2	0	0	2	2
Serine/threonine-protein kinase MARK2	0	0	2	2
ATP-dependent RNA helicase DHX30	0	0	2	2
Serine/threonine-protein kinase TAO1	0	0	2	2
STE20-related kinase adapter protein alpha	0	0	2	2
Myosin-14	0	0	2	2
AarF domain-containing protein kinase 1	0	0	2	2
ATP-dependent RNA helicase DDX42	0	0	1	1
Mitogen-activated protein kinase kinase kinase kinase 3	0	0	2	2
MAP kinase-activated protein kinase 5	0	1	2	3
Eukaryotic peptide chain release factor GTP-binding subunit ERF3B	0	0	1	1
Misshapen-like kinase 1	0	0	2	2
Atypical kinase COQ8A, mitochondrial	0	0	2	2
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma	0	0	2	2
Mitogen-activated protein kinase 15	0	0	2	2
Serine/threonine-protein kinase Nek9	0	0	2	2
ATP-dependent RNA helicase DDX1	0	0	2	2
Mitogen-activated protein kinase kinase kinase kinase 1	0	0	2	2
Aurora kinase B	0	0	2	2
Calcium/calmodulin-dependent protein kinase type 1G	0	0	2	2
Serine/threonine-protein kinase Nek1	0	0	2	2
PAS domain-containing serine/threonine-protein kinase	0	0	2	2
Calcium/calmodulin-dependent protein kinase kinase 2	0	0	2	2
EKC/KEOPS complex subunit TP53RK	0	0	2	2
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	0	0	2	2
Mitogen-activated protein kinase kinase kinase 5	0	0	2	2
Mitogen-activated protein kinase kinase kinase 3	0	0	2	2
Eukaryotic translation initiation factor 2-alpha kinase 1	0	0	2	2
Nucleolar GTP-binding protein 1	0	0	2	2
Serine/threonine-protein kinase D2	0	0	2	2
NUAK family SNF1-like kinase 2	0	0	2	2
RNA cytidine acetyltransferase	0	0	2	2
Serine/threonine-protein kinase SIK2	0	0	2	2
STE20-like serine/threonine-protein kinase	0	0	2	2
Serine/threonine-protein kinase TAO3	0	0	2	2
dCTP pyrophosphatase 1	0	0	2	2
Dual specificity protein kinase CLK4	0	0	2	2
Casein kinase I isoform gamma-1	0	0	2	2
Serine/threonine-protein kinase PAK 6	0	0	2	2
Phenylalanine--tRNA ligase beta subunit	0	0	2	2
Isoleucine--tRNA ligase, mitochondrial	0	0	1	1
BMP-2-inducible protein kinase	0	0	2	2
Obg-like ATPase 1	0	0	1	1
Midasin	0	0	2	2
Interleukin-1 receptor-associated kinase 4	0	0	2	2
Mitogen-activated protein kinase kinase kinase 20	0	0	2	2
Cyclin-dependent kinase 12	0	0	2	2
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13	0	0	2	2
Serine/threonine-protein kinase 26	0	0	2	2
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial	0	0	2	2
Serine/threonine-protein kinase NLK	0	0	2	2
5'-AMP-activated protein kinase subunit gamma-2	0	0	2	2
Serine/threonine-protein kinase TBK1	0	1	2	3
Septin-9	0	0	2	2
Ribosomal protein S6 kinase alpha-6	0	0	2	2
TRAF2 and NCK-interacting protein kinase	0	0	2	2
Serine/threonine-protein kinase TAO2	0	0	2	2
Long-chain-fatty-acid--CoA ligase 5	0	0	2	2
Serine/threonine-protein kinase ICK	0	0	2	2
RAC-gamma serine/threonine-protein kinase	0	0	2	2
Serine/threonine-protein kinase 38-like	0	0	2	2
Serine/threonine-protein kinase SIK3	0	0	2	2
Mitogen-activated protein kinase kinase kinase 2	0	0	2	2
Thyroid hormone receptor-associated protein 3	0	0	2	2
Mitogen-activated protein kinase kinase kinase kinase 5	0	0	2	2
Receptor-interacting serine/threonine-protein kinase 3	0	0	2	2
Serine/threonine-protein kinase MRCK beta	0	0	2	2
Interleukin-1 receptor-associated kinase 3	0	0	2	2
Serine/threonine-protein kinase 24	0	0	2	2
Casein kinase I isoform gamma-3	0	0	2	2
Mitogen-activated protein kinase kinase kinase 4	0	0	2	2
pregnane X receptor	2	0	0	2
cytochrome P450 family 3 subfamily A polypeptide 4	15	0	0	15
glucocorticoid receptor [Homo sapiens]	17	0	0	17
estrogen-related nuclear receptor alpha	21	0	0	21
farnesoid X nuclear receptor	11	0	0	11
pregnane X nuclear receptor	14	0	0	14
vitamin D (1,25- dihydroxyvitamin D3) receptor	12	0	0	12
IDH1	8	0	0	8
aryl hydrocarbon receptor	12	0	0	12
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	13	0	0	13
nuclear receptor subfamily 1, group I, member 2	7	0	0	7
nuclear factor erythroid 2-related factor 2 isoform 2	8	0	0	8
galanin receptor type 3	0	1	0	1
nuclear factor erythroid 2-related factor 2 isoform 1	14	0	0	14
ATP-binding cassette sub-family C member 3	0	17	0	17
Multidrug resistance-associated protein 4	0	17	0	17
Voltage-dependent calcium channel gamma-2 subunit	7	0	0	7
Glucocorticoid receptor	0	13	1	19
Glycine receptor subunit alpha-1	0	12	0	12
Glutamate receptor 2	7	1	0	8
Glycine receptor subunit beta	0	12	0	12
Glycine receptor subunit alpha-2	0	12	0	12
Glycine receptor subunit alpha-3	0	12	0	12
Canalicular multispecific organic anion transporter 1	0	16	0	16
ORF73	0	0	1	1
RAR-related orphan receptor gamma	14	0	0	14
nuclear receptor subfamily 1, group I, member 3	9	0	0	9
retinoic acid nuclear receptor alpha variant 1	13	0	0	13
thyroid stimulating hormone receptor	10	0	0	10
Cellular tumor antigen p53	14	0	0	14
Nuclear receptor ROR-gamma	5	0	0	5
glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase	0	1	0	1
Spike glycoprotein	0	1	2	3
Replicase polyprotein 1ab	0	1	2	3
glucose-6-phosphate 1-dehydrogenase isoform b	0	1	0	1
flap endonuclease 1	6	0	0	6
Transmembrane protease serine 2	0	1	2	3
Dihydrofolate reductase	0	1	0	1
DNA ligase	0	1	0	1
Riboflavin-binding protein	0	1	2	3
Major prion protein	0	0	2	2
Amyloid-beta precursor protein	0	3	0	3
Histidine-rich protein PFHRP-II	0	2	0	3
Procathepsin L	0	1	2	3
Muscarinic acetylcholine receptor M2	0	5	0	6
Muscarinic acetylcholine receptor M4	0	6	0	7
Cytochrome P450 3A4	0	4	0	4
Muscarinic acetylcholine receptor M5	0	6	0	7
Alpha-2A adrenergic receptor	0	10	0	11
Replicase polyprotein 1a	0	1	2	3
Replicase polyprotein 1ab	0	1	2	3
Replicase polyprotein 1ab	0	2	2	4
Spike glycoprotein	0	1	0	1
Replicase polyprotein 1ab	0	3	2	5
Muscarinic acetylcholine receptor M1	0	6	0	7
Alpha-2B adrenergic receptor	0	10	0	11
Alpha-2C adrenergic receptor	0	10	0	11
DNA ligase 1	0	1	0	1
Muscarinic acetylcholine receptor M3	0	6	0	7
Serine/threonine-protein kinase mTOR	0	1	1	2
Nuclear receptor subfamily 4 group A member 2	0	0	1	1
Beta-secretase 1	0	1	0	1
Spike glycoprotein	8	1	2	11
Calcium-dependent protein kinase 1	0	0	1	1
MO15-related protein kinase Pfmrk	0	1	0	1
DNA ligase A	0	1	0	1
Potassium voltage-gated channel subfamily H member 2	0	7	0	7
Sigma intracellular receptor 2	0	2	0	2
Phosphoethanolamine N-methyltransferase	0	1	0	1
Ataxin-2	12	0	0	12
Sigma non-opioid intracellular receptor 1	0	6	0	6
Angiotensin-converting enzyme 2	0	1	2	3
Cysteine proteinase falcipain 2a	0	1	0	1
Cysteine proteinase falcipain 2a	0	1	0	1
Chain A, Cruzipain	2	0	0	2
Luciferase	4	0	0	4
interleukin 8	3	0	0	3
15-lipoxygenase, partial	2	0	0	2
USP1 protein, partial	11	0	0	11
Microtubule-associated protein tau	6	0	0	6
retinoid X nuclear receptor alpha	15	0	0	15
peroxisome proliferator-activated receptor delta	9	0	0	9
peroxisome proliferator activated receptor gamma	10	0	0	10
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	4	0	0	4
vitamin D3 receptor isoform VDRA	5	0	0	5
nuclear receptor ROR-gamma isoform 1	6	0	0	6
geminin	17	0	0	17
DNA polymerase kappa isoform 1	2	0	0	2
survival motor neuron protein isoform d	6	0	0	6
cytochrome P450 3A4 isoform 1	10	0	0	10
Gamma-aminobutyric acid receptor subunit pi	10	0	0	10
60 kDa chaperonin	0	2	0	2
60 kDa heat shock protein, mitochondrial	0	2	0	2
Vitamin D3 receptor	0	1	1	5
Gamma-aminobutyric acid receptor subunit beta-1	10	0	0	10
Gamma-aminobutyric acid receptor subunit delta	10	0	0	10
Gamma-aminobutyric acid receptor subunit gamma-2	10	0	0	10
Gamma-aminobutyric acid receptor subunit alpha-5	10	0	0	10
Gamma-aminobutyric acid receptor subunit alpha-3	10	0	0	10
Glycine receptor subunit alpha-1	0	0	2	2
Gamma-aminobutyric acid receptor subunit gamma-1	10	0	0	10
Gamma-aminobutyric acid receptor subunit alpha-2	10	0	0	10
Gamma-aminobutyric acid receptor subunit alpha-4	10	0	0	10
Gamma-aminobutyric acid receptor subunit gamma-3	10	0	0	10
Gamma-aminobutyric acid receptor subunit alpha-6	10	0	0	10
Vitamin D3 receptor	0	0	1	1
10 kDa heat shock protein, mitochondrial	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-1	10	0	0	10
Gamma-aminobutyric acid receptor subunit beta-3	10	0	0	10
Gamma-aminobutyric acid receptor subunit beta-2	10	0	0	10
Thiosulfate sulfurtransferase	0	2	0	2
60 kDa chaperonin	0	2	0	2
10 kDa chaperonin	0	2	0	2
GABA theta subunit	10	0	0	10
Gamma-aminobutyric acid receptor subunit epsilon	10	0	0	10
endonuclease IV	4	0	0	4
acetylcholinesterase	5	0	0	5
SMAD family member 2	7	0	0	7
GLS protein	5	0	0	5
SMAD family member 3	7	0	0	7
Thrombopoietin	3	0	0	3
thyroid stimulating hormone receptor	6	0	0	6
G	9	0	0	9
bromodomain adjacent to zinc finger domain 2B	7	0	0	7
peripheral myelin protein 22 isoform 1	6	0	0	6
cytochrome P450 2C9 precursor	5	0	0	5
mitogen-activated protein kinase 1	7	0	0	7
peripheral myelin protein 22	7	0	0	7
M-phase phosphoprotein 8	5	0	0	5
neuropeptide S receptor isoform A	4	0	0	4
Voltage-dependent L-type calcium channel subunit alpha-1F	0	3	0	3
HLA class I histocompatibility antigen, B alpha chain	9	0	0	9
Cytochrome P450 2C9	0	5	1	6
Histamine H2 receptor	5	0	0	5
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	0	1	0	1
Guanine nucleotide-binding protein G	2	0	0	2
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	3	0	3
cGMP-inhibited 3',5'-cyclic phosphodiesterase B	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	3	0	3
Voltage-dependent L-type calcium channel subunit alpha-1C	0	3	0	4
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	0	2	0	2
cGMP-inhibited 3',5'-cyclic phosphodiesterase A	0	2	0	2
Inositol hexakisphosphate kinase 1	9	0	0	9
cytochrome P450 2C9, partial	9	0	0	9
ATP-dependent phosphofructokinase	8	0	0	8
Chain A, Beta-lactamase	7	0	0	7
chaperonin-containing TCP-1 beta subunit homolog	1	0	0	1
hypoxia-inducible factor 1 alpha subunit	8	0	0	8
Estrogen receptor 1	0	1	0	1
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	9	0	0	9
PINK1	1	0	0	1
estrogen receptor 2 (ER beta)	3	0	0	3
cytochrome P450 2D6	7	0	0	7
Parkin	2	0	0	2
v-jun sarcoma virus 17 oncogene homolog (avian)	6	0	0	6
Histone H2A.x	4	0	0	4
lysosomal alpha-glucosidase preproprotein	4	0	0	4
chromobox protein homolog 1	10	0	0	10
potassium voltage-gated channel subfamily H member 2 isoform d	3	0	0	3
thyroid hormone receptor beta isoform 2	8	0	0	8
estrogen receptor beta isoform 1	0	1	0	1
heat shock protein beta-1	7	0	0	7
Aldo-keto reductase family 1 member B1	0	4	0	4
Neuronal acetylcholine receptor subunit alpha-4	3	0	0	3
Neuronal acetylcholine receptor subunit beta-2	3	0	0	3
D(2) dopamine receptor	0	4	0	4
5-hydroxytryptamine receptor 1A	0	7	0	7
Sodium-dependent noradrenaline transporter	0	6	0	6
Alpha-1D adrenergic receptor	0	10	1	13
Cruzipain	0	1	0	1
5-hydroxytryptamine receptor 2A	0	7	0	7
5-hydroxytryptamine receptor 1B	0	6	0	6
Sodium-dependent serotonin transporter	0	4	0	4
Histamine H1 receptor	0	2	0	2
Mu-type opioid receptor	0	4	0	4
D(3) dopamine receptor	0	7	0	7
5-hydroxytryptamine receptor 2B	0	6	0	6
Inositol monophosphatase 1	3	0	0	3
Sodium-dependent dopamine transporter	0	4	0	4
Chain A, CHIMERA OF IG KAPPA CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION	0	0	1	1
Chain B, CHIMERA OF IG GAMMA-1 CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION	0	0	1	1
Chain H, Fab M82G2, Heavy chain	0	0	1	1
Chain L, Fab M82G2, Light chain	0	0	1	1
Chain H, Fab M82g2, Heavy Chain	0	0	1	1
Chain L, Fab M82g2, Light Chain	0	0	1	1
Gamma-aminobutyric acid receptor subunit pi	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	0	1	0	1
Fatty acid-binding protein, heart	0	1	0	1
Muscarinic acetylcholine receptor M2	0	1	0	1
Muscarinic acetylcholine receptor M1	0	2	0	2
5-hydroxytryptamine receptor 2C	0	4	0	4
Tryptophan 5-hydroxylase 1	0	1	0	1
5-hydroxytryptamine receptor 2A	0	5	0	5
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	0	1
D	0	3	0	3
Alpha-2B adrenergic receptor	0	2	1	3
Alpha-2C adrenergic receptor	0	2	1	3
Alpha-2A adrenergic receptor	0	2	1	3
Liver carboxylesterase 1	0	0	0	1
Sodium-dependent dopamine transporter	0	3	0	3
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	3	0	3
Gamma-aminobutyric acid receptor subunit beta-3	0	1	0	1
5-hydroxytryptamine receptor 1D	0	2	0	2
5-hydroxytryptamine receptor 1F	0	2	0	2
5-hydroxytryptamine receptor 2B	0	3	0	3
5-hydroxytryptamine receptor 6	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	1	0	1
Sodium-dependent serotonin transporter	0	3	0	4
5-hydroxytryptamine receptor 7	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	0	1
5-hydroxytryptamine receptor 5A	0	1	0	1
5-hydroxytryptamine receptor 5B	0	1	0	1
5-hydroxytryptamine receptor 3A	0	1	0	1
Lysosomal Pro-X carboxypeptidase	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	0	1
D(2) dopamine receptor	0	4	0	4
Gamma-aminobutyric acid receptor subunit epsilon	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	3	0	3
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	3	0	3
Leukotriene B4 receptor 1	0	1	0	2
Gamma-aminobutyric acid receptor subunit alpha-6	0	1	0	1
Sodium-dependent dopamine transporter	0	2	0	2
5-hydroxytryptamine receptor 4	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	1	0	1
5-hydroxytryptamine receptor 3B	0	1	0	1
Leukotriene B4 receptor 2	0	1	0	2
Gamma-aminobutyric acid receptor subunit theta	0	1	0	1
Transporter	0	2	0	2
activating transcription factor 6	8	0	0	8
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	6	0	0	6
Rap guanine nucleotide exchange factor 3	3	0	0	3
Glutathione S-transferase P	0	1	0	1
Alpha-tocopherol transfer protein	0	0	1	1
6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase	0	1	0	1
Smad3	4	0	0	4
67.9K protein	7	0	0	7
muscleblind-like protein 1 isoform 1	6	0	0	6
Bile salt export pump	0	3	0	3
Myeloperoxidase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
5-hydroxytryptamine receptor 6	0	3	0	3
caspase 7, apoptosis-related cysteine protease	3	0	0	3
caspase-3	3	0	0	3
Serum paraoxonase/arylesterase 1	0	1	0	1
Kinesin-like protein KIF11	0	1	0	1
ATPase family AAA domain-containing protein 5	10	0	0	10
Nucleotide-binding oligomerization domain-containing protein 2	0	1	0	1
Adenylate cyclase	0	1	0	1
5-hydroxytryptamine receptor 4	0	4	0	4
ATP-dependent translocase ABCB1	0	2	0	2
Beta-2 adrenergic receptor	0	2	0	2
ATP-dependent translocase ABCB1	0	4	1	6
Beta-1 adrenergic receptor	0	2	0	2
ATP-dependent translocase ABCB1	0	2	0	2
D(1A) dopamine receptor	0	2	0	2
Thromboxane-A synthase	0	2	0	2
5-hydroxytryptamine receptor 1B	0	2	0	2
5-hydroxytryptamine receptor 2C	0	4	0	4
5-hydroxytryptamine receptor 5A	0	1	0	1
Chain A, 2-oxoglutarate Oxygenase	7	0	0	7
DNA polymerase iota isoform a (long)	7	0	0	7
urokinase-type plasminogen activator precursor	4	0	0	4
plasminogen precursor	4	0	0	4
urokinase plasminogen activator surface receptor precursor	4	0	0	4
Genome polyprotein	0	1	0	1
Cyclic GMP-AMP synthase	0	2	0	2
Toll-like receptor 9	0	1	0	1
Toll-like receptor 7	0	1	0	1
histone deacetylase 9 isoform 3	2	0	0	2
Cereblon isoform 4	0	3	0	3
Bromodomain-containing protein 4	0	1	0	1
DNA-binding protein Ikaros	0	0	1	4
DNA damage-binding protein 1	0	2	1	3
Protein cereblon	0	4	2	9
Zinc finger protein Aiolos	0	0	1	1
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Androgen receptor	0	3	0	3
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
glp-1 receptor, partial	6	0	0	6
Fumarate hydratase	4	0	0	4
isocitrate dehydrogenase 1, partial	1	0	0	1
polyprotein	4	0	0	4
Caspase-7	2	0	0	2
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	1	0	0	1
caspase-3	2	0	0	2
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	1	0	0	1
DNA dC->dU-editing enzyme APOBEC-3F isoform a	2	0	0	2
Progesterone receptor	0	2	1	4
Solute carrier organic anion transporter family member 1B3	0	2	0	2
Solute carrier organic anion transporter family member 1B1	0	2	0	2
cytochrome P450 2D6 isoform 1	3	0	0	3
pyruvate kinase PKM isoform b	1	0	0	1
Ornithine decarboxylase	1	0	0	1
Chain A, Inosine-5'-Monophosphate Dehydrogenase 2	0	1	0	1
UDP-glucuronosyltransferase 1A9	0	0	0	1
Glutamate receptor 1	0	1	0	1
Glutamate receptor 3	0	1	0	1
Glutamate receptor 4	0	1	0	1
Inosine-5'-monophosphate dehydrogenase 1	0	2	0	2
UDP-glucuronosyltransferase 1A1	0	0	0	1
Peroxisome proliferator-activated receptor gamma	0	0	3	3
Alpha-synuclein	1	0	0	1
TAR DNA-binding protein 43	2	0	0	2
Inosine-5'-monophosphate dehydrogenase	0	1	0	2
UDP-glucuronosyltransferase 1A7	0	0	0	1
UDP-glucuronosyltransferase 1A10	0	0	0	1
UDP-glucuronosyltransferase 1A8	0	0	0	1
Chain A, JmjC domain-containing histone demethylation protein 3A	4	0	0	4
thyrotropin-releasing hormone receptor	1	0	0	1
Polyphenol oxidase 2	0	1	0	1
Cholesteryl ester transfer protein	0	1	0	1
D-amino-acid oxidase	0	1	0	1
Xanthine dehydrogenase/oxidase	0	1	0	1
Hydroxycarboxylic acid receptor 3	0	0	1	1
Nicotinamidase	0	1	0	1
Hydroxycarboxylic acid receptor 2	0	0	1	1
Hydroxycarboxylic acid receptor 2	0	2	1	3
Multidrug and toxin extrusion protein 1	0	2	0	2
D-aspartate oxidase	0	1	0	1
Hydroxycarboxylic acid receptor 2	0	1	1	2
Chain A, NAD-dependent deacetylase	0	1	0	1
Poly [ADP-ribose] polymerase 2	0	1	0	1
NAD-dependent histone deacetylase SIR2	0	1	0	1
Coagulation factor VII	0	1	0	1
Poly [ADP-ribose] polymerase 1	0	1	0	1
Tissue factor	0	1	0	1
Cytochrome P450 3A5	0	1	0	1
NAD-dependent protein deacetylase HST2	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
Protein mono-ADP-ribosyltransferase PARP15	0	1	0	1
NAD(+) hydrolase SARM1	0	1	0	1
NAD-dependent protein deacetylase sirtuin-2	0	1	0	1
NAD-dependent protein deacetylase sirtuin-6	0	1	0	1
NAD-dependent protein deacetylase sirtuin-1	0	1	0	1
NAD-dependent protein deacetylase sirtuin-3, mitochondrial	0	1	0	1
NAD-dependent protein deacylase sirtuin-5, mitochondrial	0	1	0	1
NAD-dependent protein deacetylase	0	1	0	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	1	0	0	1
ATAD5 protein, partial	7	0	0	7
NFKB1 protein, partial	3	0	0	3
hypothetical protein, conserved	1	0	0	1
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	3	0	0	3
beta-2 adrenergic receptor	2	0	0	2
cellular tumor antigen p53 isoform a	2	0	0	2
tumor necrosis factor	1	0	0	1
polyunsaturated fatty acid lipoxygenase ALOX12	1	0	0	1
perilipin-5	0	1	0	1
perilipin-1	0	1	0	1
atrial natriuretic peptide receptor 2 precursor	1	0	0	1
serine/threonine-protein kinase mTOR isoform 1	3	0	0	3
serine/threonine-protein kinase PLK1	2	0	0	2
eyes absent homolog 2 isoform a	2	0	0	2
histone-lysine N-methyltransferase 2A isoform 2 precursor	2	0	0	2
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a	0	1	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15B	2	0	0	2
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Potassium channel subfamily K member 2	0	0	1	1
Glutathione reductase, mitochondrial	0	3	0	3
Integrin beta-3	2	0	0	2
Integrin alpha-IIb	2	0	0	2
Adenosine receptor A3	0	2	0	2
Polyunsaturated fatty acid lipoxygenase ALOX15	0	1	0	1
Phospholipase A2, membrane associated	0	1	0	2
Alpha-1B adrenergic receptor	0	5	1	6
Voltage-dependent L-type calcium channel subunit alpha-1C	0	2	0	2
Potassium voltage-gated channel subfamily A member 5	0	1	0	1
3-oxo-5-alpha-steroid 4-dehydrogenase 1	0	1	0	1
Platelet-activating factor receptor	0	0	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	1	0	1
Indoleamine 2,3-dioxygenase 1	0	1	0	1
Adenosine receptor A2a	0	1	0	1
Adenosine receptor A1	0	2	0	2
Adenosine receptor A2a	0	1	0	1
3-oxo-5-alpha-steroid 4-dehydrogenase 2	0	1	0	1
Sodium channel protein type 1 subunit alpha	0	1	0	1
Sodium channel protein type 4 subunit alpha	0	1	0	1
C-C chemokine receptor type 2	0	2	0	2
Alpha-1A adrenergic receptor	0	5	1	6
Cytochrome P450 2J2	0	3	0	3
Sodium channel protein type 7 subunit alpha	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	1	0	1
Potassium voltage-gated channel subfamily A member 1	0	1	0	1
C-terminal-binding protein 1	1	0	0	1
Sodium channel protein type 5 subunit alpha	0	1	0	1
Sodium channel protein type 9 subunit alpha	0	1	0	1
Transient receptor potential cation channel subfamily A member 1	0	0	1	1
Potassium channel subfamily K member 2	0	1	0	1
Beta-2 adrenergic receptor	0	0	0	1
Indoleamine 2,3-dioxygenase 2	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1F	0	1	0	1
Sodium channel protein type 3 subunit alpha	0	1	0	1
Sodium channel protein type 11 subunit alpha	0	1	0	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	2	0	3
Sodium channel protein type 8 subunit alpha	0	1	0	1
Sodium channel protein type 10 subunit alpha	0	1	0	1
dopamine D1 receptor	2	0	0	2
vasopressin V1b receptor	1	0	0	1
ubiquitin carboxyl-terminal hydrolase 2 isoform a	2	0	0	2
relaxin receptor 1 isoform 1	1	0	0	1
cGMP-dependent 3',5'-cyclic phosphodiesterase	0	1	0	1
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A	0	1	0	1
cGMP-specific 3',5'-cyclic phosphodiesterase	0	1	0	1
Tumor necrosis factor	0	1	0	1
Cholinesterase	0	1	0	1
Acetylcholinesterase	0	2	0	2
Adenosine receptor A2b	0	1	0	1
Disintegrin and metalloproteinase domain-containing protein 17	1	0	0	1
Chitotriosidase-1	0	2	1	3
Endochitinase B1	0	2	1	3
Solute carrier family 22 member 2	0	2	0	2
Solute carrier family 22 member 1	0	2	0	2
Solute carrier family 22 member 3	0	2	0	2
D(3) dopamine receptor	0	1	0	1
Alpha-1D adrenergic receptor	0	3	1	4
D(1B) dopamine receptor	0	1	0	1
D(4) dopamine receptor	0	1	0	1
5-hydroxytryptamine receptor 7	0	2	0	2
GALC protein	1	0	0	1
mu-type opioid receptor isoform MOR-1	0	0	1	1
Vpr	1	0	0	1
5-hydroxytryptamine receptor 2A	0	0	1	1
glucocerebrosidase	1	0	0	1
NPC intracellular cholesterol transporter 1 precursor	2	0	0	2
interferon gamma precursor	0	0	0	1
ras-related protein Rab-9A	2	0	0	2
Alpha-1A adrenergic receptor	0	1	1	2
Beta-casein	0	1	0	1
Interstitial collagenase	0	1	0	1
5-hydroxytryptamine receptor 1A	0	1	0	1
Angiotensin-converting enzyme	0	2	0	2
Matrix metalloproteinase-9	0	1	0	1
Alpha-1A adrenergic receptor	0	1	0	1
Alpha-1B adrenergic receptor	0	1	0	1
Alpha-2A adrenergic receptor	0	1	0	1
Alpha-mannosidase 2C1	0	0	1	1
D(4) dopamine receptor	0	1	0	1
Bromodomain-containing protein 2	0	2	0	2
Alpha-2B adrenergic receptor	0	1	0	1
3-oxo-5-alpha-steroid 4-dehydrogenase 2	0	1	0	1
Delta-type opioid receptor	0	1	0	1
Type-1 angiotensin II receptor	0	1	0	1
Alpha-1A adrenergic receptor	0	2	1	7
Alpha-1B adrenergic receptor	0	2	1	5
D(1A) dopamine receptor	2	0	0	2
Alpha-2C adrenergic receptor	0	1	0	1
Alpha-2A adrenergic receptor	0	1	0	1
Alpha-2A adrenergic receptor	0	1	0	1
Nuclear receptor subfamily 3 group C member 3	0	2	0	2
Multidrug and toxin extrusion protein 2	0	1	0	1
luciferase	0	0	0	1
Fatty acid-binding protein, liver	0	1	0	1
Estrogen receptor	0	2	0	2
Glucocorticoid receptor	0	1	1	2
Glucocorticoid receptor	0	0	1	1
Corticosteroid-binding globulin	0	1	0	1
Mineralocorticoid receptor	0	2	1	3
Androgen receptor	0	2	0	2
Glutamine synthetase	0	0	1	1
Histamine H1 receptor	0	0	1	1
Prostaglandin G/H synthase 2	0	2	1	3
Nociceptin receptor	0	0	1	1
Estrogen receptor beta	0	2	0	2
N	0	1	0	1
NPYLR7B	0	0	1	1
cystic fibrosis transmembrane conductance regulator	0	1	0	1
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	2	0	0	2
tumor susceptibility gene 101 protein	1	0	0	1
Major prion protein	0	1	0	1
Muscarinic acetylcholine receptor M3	0	1	0	1
Muscarinic acetylcholine receptor M4	0	1	0	1
Muscarinic acetylcholine receptor M5	0	1	0	1
DNA-directed RNA polymerase subunit alpha	0	1	0	1
DNA-directed RNA polymerase subunit omega	0	1	0	1
DNA-directed RNA polymerase subunit beta'	0	1	0	1
DNA-directed RNA polymerase subunit beta	0	1	0	1
Muscarinic acetylcholine receptor M2	0	1	0	1
Phospholipase A2, membrane associated	0	1	0	1
Acidic phospholipase A2 2	0	1	0	1
Histamine H2 receptor	0	2	0	2
Trypanothione reductase	0	2	0	2
Aldehyde oxidase 1	0	1	0	1
Cholinesterase	0	1	0	1
Aldehyde oxidase	0	1	0	1
2,3-bisphosphoglycerate-independent phosphoglycerate mutase	1	0	0	1
hemoglobin subunit beta	1	0	0	1
DNA polymerase beta	1	0	0	1
nuclear factor NF-kappa-B p105 subunit isoform 1	1	0	0	1
DNA polymerase eta isoform 1	1	0	0	1
lethal(3)malignant brain tumor-like protein 1 isoform I	1	0	0	1
caspase-1 isoform alpha precursor	1	0	0	1
Quinolone resistance protein NorA	0	1	0	2
DNA topoisomerase 1	0	1	0	1
Chromaffin granule amine transporter	0	1	0	1
Caspase-7	1	0	0	1
Synaptic vesicular amine transporter	0	1	0	1
Synaptic vesicular amine transporter	0	2	1	3
Synaptic vesicular amine transporter	0	1	0	1
Solute carrier family 22 member 1	0	1	0	1
Prostaglandin E synthase	0	1	0	1
Aldo-keto reductase family 1 member B10	0	1	0	1
Complement C5	0	0	1	1
Albumin	0	1	0	1
Prostaglandin G/H synthase 1	0	2	0	2
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	1
Aldo-keto reductase family 1 member B1	0	1	0	1
Aldo-keto reductase family 1 member B1	0	1	0	1
Retinoic acid receptor RXR-alpha	0	1	0	1
Lactoylglutathione lyase	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	1	0	1
Chain A, Tyrosine-protein kinase	0	1	0	1
Chain A, Tyrosine-protein kinase	0	1	0	1
Chain A, Tyrosine-protein kinase JAK2	0	1	0	1
Leukotriene C4 synthase	0	0	1	1
tyrosine-protein kinase Yes	1	0	0	1
Serine/threonine-protein kinase Sgk1	0	1	0	1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	0	0	1	1
Serine/threonine-protein kinase 25	0	0	1	1
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta	0	0	1	1
Serine/threonine-protein kinase RIO3	0	0	1	1
Dual specificity mitogen-activated protein kinase kinase 7	0	1	1	2
Inhibitor of nuclear factor kappa-B kinase subunit beta	0	0	1	1
Peripheral plasma membrane protein CASK	0	0	1	1
Serine/threonine-protein kinase DCLK1	0	0	1	1
Inhibitor of nuclear factor kappa-B kinase subunit alpha	0	0	1	1
Muscle, skeletal receptor tyrosine-protein kinase	0	0	1	1
Mitogen-activated protein kinase 13	0	1	1	2
3-phosphoinositide-dependent protein kinase 1	0	0	1	1
Mitogen-activated protein kinase kinase kinase 13	0	0	1	1
Death-associated protein kinase 3	0	0	1	1
Mitogen-activated protein kinase kinase kinase 7	0	0	1	1
Mitotic checkpoint serine/threonine-protein kinase BUB1	0	0	1	1
NUAK family SNF1-like kinase 1	0	0	1	1
Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma	0	0	1	1
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	0	0	1	1
Serine/threonine-protein kinase PAK 3	0	0	1	1
Cyclin-dependent kinase-like 5	0	0	1	1
Serine/threonine-protein kinase 17B	0	0	1	1
Cyclin-dependent kinase 14	0	0	1	1
Serine/threonine-protein kinase OSR1	0	0	1	1
Serine/threonine-protein kinase Chk2	0	0	1	1
RAF proto-oncogene serine/threonine-protein kinase	0	0	1	1
Receptor tyrosine-protein kinase erbB-2	0	1	1	2
High affinity nerve growth factor receptor	0	0	1	1
Macrophage colony-stimulating factor 1 receptor	0	0	1	1
Proto-oncogene tyrosine-protein kinase ROS	0	0	1	1
Tyrosine-protein kinase Fgr	0	0	1	1
Wee1-like protein kinase 2	0	0	1	1
Uncharacterized serine/threonine-protein kinase SBK3	0	0	1	1
Cytochrome P450 2C8	0	1	0	1
Cytochrome P450 2D6	0	1	0	1
Mast/stem cell growth factor receptor Kit	0	0	1	1
Cytochrome P450 2A6	0	1	0	1
Myosin light chain kinase, smooth muscle	0	0	1	1
Insulin receptor-related protein	0	0	1	1
Platelet-derived growth factor receptor alpha	0	0	1	1
Vascular endothelial growth factor receptor 1	0	0	1	1
Interferon-induced, double-stranded RNA-activated protein kinase	0	0	1	1
Serine/threonine-protein kinase MAK	0	0	1	1
Cyclin-dependent kinase 11B	0	0	1	1
Fibroblast growth factor receptor 2	0	0	1	1
Receptor tyrosine-protein kinase erbB-3	0	0	1	1
Fibroblast growth factor receptor 4	0	0	1	1
Fibroblast growth factor receptor 3	0	0	1	1
Protein kinase C eta type	0	0	1	1
Activin receptor type-2A	0	0	1	1
Ephrin type-A receptor 3	0	0	1	1
Ephrin type-A receptor 8	0	0	1	1
Leukocyte tyrosine kinase receptor	0	0	1	1
Tyrosine-protein kinase receptor UFO	0	0	1	1
Mitogen-activated protein kinase 4	0	0	1	1
G protein-coupled receptor kinase 4	0	0	1	1
Cytochrome P450 2C19	0	1	0	1
Dual specificity protein kinase TTK	0	0	1	1
Tyrosine-protein kinase receptor Tie-1	0	0	1	1
Vascular endothelial growth factor receptor 3	0	0	1	1
Vascular endothelial growth factor receptor 2	0	0	1	1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	0	1	1	2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0	0	1	1
Megakaryocyte-associated tyrosine-protein kinase	0	0	1	1
Tyrosine-protein kinase TXK	0	1	1	2
Tyrosine-protein kinase ZAP-70	0	0	1	1
Dual specificity mitogen-activated protein kinase kinase 4	0	0	1	1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	0	0	1	1
Cyclin-dependent kinase 8	0	0	1	1
Tyrosine-protein kinase Blk	0	1	1	2
Cytoplasmic tyrosine-protein kinase BMX	0	1	1	2
cAMP-dependent protein kinase catalytic subunit PRKX	0	0	1	1
Serine/threonine-protein kinase Nek4	0	0	1	1
Serine/threonine-protein kinase PLK1	0	0	1	1
Death-associated protein kinase 1	0	0	1	1
Mitogen-activated protein kinase 12	0	1	1	2
5'-AMP-activated protein kinase catalytic subunit alpha-2	0	0	1	1
Ephrin type-B receptor 1	0	0	1	1
Hormonally up-regulated neu tumor-associated kinase	0	0	1	1
Serine/threonine-protein kinase SIK1	0	0	1	1
Receptor-interacting serine/threonine-protein kinase 4	0	0	1	1
Cell division control protein 2 homolog	0	0	1	1
Calcium-dependent protein kinase 1	0	0	1	1
Tubulin alpha-1A chain	0	0	1	1
Casein kinase II subunit alpha	0	0	1	1
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta	0	0	1	1
SRSF protein kinase 2	0	0	1	1
Mitogen-activated protein kinase kinase kinase 9	0	0	1	1
Serine/threonine-protein kinase PknB	0	0	1	1
Cyclin-dependent kinase-like 1	0	0	1	1
Protein kinase C epsilon type	0	0	1	1
Angiopoietin-1 receptor	0	0	1	1
Mitogen-activated protein kinase kinase kinase 10	0	0	1	1
Tyrosine-protein kinase receptor TYRO3	0	0	1	1
Cyclin-dependent kinase 18	0	0	1	1
Tyrosine-protein kinase ITK/TSK	0	1	1	2
Myotonin-protein kinase	0	0	1	1
Mitogen-activated protein kinase kinase kinase 12	0	0	1	1
Tyrosine-protein kinase Mer	0	0	1	1
Serine/threonine-protein kinase PAK 1	0	0	1	1
cGMP-dependent protein kinase 2	0	0	1	1
Serine/threonine-protein kinase PRP4 homolog	0	0	1	1
Receptor-interacting serine/threonine-protein kinase 1	0	0	1	1
Calcium/calmodulin-dependent protein kinase type II subunit beta	0	0	1	1
Calcium/calmodulin-dependent protein kinase type 1	0	0	1	1
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial	0	1	0	1
Serine/threonine-protein kinase D1	0	0	1	1
Serine/threonine-protein kinase 38	0	0	1	1
Receptor tyrosine-protein kinase erbB-4	0	1	1	2
Ribosomal protein S6 kinase alpha-2	0	0	1	1
Rhodopsin kinase GRK1	0	0	1	1
NT-3 growth factor receptor	0	0	1	1
BDNF/NT-3 growth factors receptor	0	0	1	1
Mitogen-activated protein kinase 6	0	0	1	1
Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform	0	0	1	1
Serine/threonine-protein kinase SBK1	0	0	1	1
Mitogen-activated protein kinase kinase kinase 19	0	0	1	1
Serine/threonine-protein kinase TNNI3K	0	0	1	1
Leucine-rich repeat serine/threonine-protein kinase 2	0	0	1	1
Sigma intracellular receptor 2	0	1	0	1
Tyrosine-protein kinase JAK3	0	1	0	1
Tyrosine-protein kinase JAK2	0	1	0	1
Tyrosine-protein kinase JAK3	0	1	0	1
Serine/threonine-protein kinase Nek5	0	0	1	1
Dual serine/threonine and tyrosine protein kinase	0	0	1	1
Mitogen-activated protein kinase kinase kinase 15	0	0	1	1
Serine/threonine-protein kinase tousled-like 2	0	0	1	1
Serine/threonine-protein kinase 32C	0	0	1	1
Serine/threonine-protein kinase pim-3	0	0	1	1
Serine/threonine-protein kinase VRK2	0	0	1	1
Myosin light chain kinase family member 4	0	0	1	1
Homeodomain-interacting protein kinase 1	0	0	1	1
Calcium/calmodulin-dependent protein kinase type 1D	0	0	1	1
Cyclin-dependent kinase-like 3	0	0	1	1
Serine/threonine-protein kinase BRSK2	0	0	1	1
Serine/threonine-protein kinase NIM1	0	0	1	1
Serine/threonine-protein kinase ULK2	0	0	1	1
Serine/threonine-protein kinase DCLK2	0	0	1	1
Calcium/calmodulin-dependent protein kinase kinase 1	0	0	1	1
Casein kinase I isoform alpha-like	0	0	1	1
Homeodomain-interacting protein kinase 4	0	0	1	1
Myosin-IIIa	0	0	1	1
Ankyrin repeat and protein kinase domain-containing protein 1	0	0	1	1
Serine/threonine-protein kinase Nek11	0	0	1	1
Serine/threonine-protein kinase BRSK1	0	0	1	1
Serine/threonine-protein kinase 35	0	0	1	1
Serine/threonine-protein kinase Nek7	0	0	1	1
Rhodopsin kinase GRK7	0	0	1	1
Serine/threonine-protein kinase 32A	0	0	1	1
Myosin-IIIb	0	0	1	1
Dual specificity tyrosine-phosphorylation-regulated kinase 2	0	0	1	1
Cyclin-dependent kinase-like 2	0	0	1	1
Serine/threonine-protein kinase Sgk3	0	0	1	1
Atypical kinase COQ8B, mitochondrial	0	0	1	1
MAP/microtubule affinity-regulating kinase 4	0	0	1	1
Cyclin-dependent kinase 15	0	0	1	1
Dual specificity testis-specific protein kinase 2	0	0	1	1
SRSF protein kinase 1	0	0	1	1
Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha	0	0	1	1
Serine/threonine-protein kinase RIO1	0	0	1	1
MAP kinase-interacting serine/threonine-protein kinase 1	0	0	1	1
Serine/threonine-protein kinase RIO2	0	0	1	1
Cyclin-dependent kinase 19	0	0	1	1
Transient receptor potential cation channel subfamily M member 6	0	0	1	1
Testis-specific serine/threonine-protein kinase 1	0	0	1	1
Serine/threonine-protein kinase 33	0	0	1	1
Serine/threonine-protein kinase DCLK3	0	0	1	1
Myosin light chain kinase 2, skeletal/cardiac muscle	0	0	1	1
Homeodomain-interacting protein kinase 2	0	0	1	1
Tyrosine-protein kinase Srms	0	0	1	1
Homeodomain-interacting protein kinase 3	0	0	1	1
Serine/threonine-protein kinase PLK3	0	0	1	1
MAP kinase-interacting serine/threonine-protein kinase 2	0	0	1	1
Serine/threonine-protein kinase Nek6	0	0	1	1
SNF-related serine/threonine-protein kinase	0	0	1	1
Serine/threonine-protein kinase LATS2	0	0	1	1
Serine/threonine-protein kinase 36	0	0	1	1
Serine/threonine-protein kinase 32B	0	0	1	1
Serine/threonine-protein kinase PLK2	0	0	1	1
Serine/threonine-protein kinase MARK1	0	0	1	1
Serine/threonine-protein kinase pim-2	0	0	1	1
Serine/threonine-protein kinase PAK 5	0	0	1	1
eIF-2-alpha kinase GCN2	0	0	1	1
Phosphatidylinositol 4-kinase beta	0	0	1	1
Serine/threonine-protein kinase 17A	0	0	1	1
STE20/SPS1-related proline-alanine-rich protein kinase	0	0	1	1
Ephrin type-A receptor 6	0	0	1	1
Death-associated protein kinase 2	0	0	1	1
Serine/threonine-protein kinase tousled-like 1	0	0	1	1
ALK tyrosine kinase receptor	0	0	1	1
SRSF protein kinase 3	0	0	1	1
Cyclin-dependent kinase 11A	0	0	1	1
Aurora kinase C	0	0	1	1
Calcium/calmodulin-dependent protein kinase type II subunit alpha	0	0	1	1
Microtubule-associated serine/threonine-protein kinase 1	0	0	1	1
Dual specificity tyrosine-phosphorylation-regulated kinase 1B	0	0	1	1
thioredoxin glutathione reductase	3	0	0	3
procathepsin L isoform 1 preproprotein	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

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Chilblains

Synonyms(4)

Research Excerpts

Overview

Treatment

Research

Studies (92)

Drugs Studied (57)

Protein Targets (1,074)