Keratosis, Actinic

White or pink lesions on the arms, hands, face, or scalp that arise from sun-induced DNA DAMAGE to KERATINOCYTES in exposed areas. They are considered precursor lesions to superficial SQUAMOUS CELL CARCINOMA.

Synonym
Keratosis, Actinic

Excerpt	Reference
"actinic keratosis is a premalignant disease with a high incidence and is a strong predictor for the development of squamous cell carcinoma."	( Gollnick, HP; Quist, SR, 2011)
"Actinic keratosis is a common precursor to sun-related squamous-cell carcinoma."	( Anderson, LL; Berman, B; Lebwohl, M; Melgaard, A; Swanson, N; Xu, Z, 2012)
"Actinic keratosis is one of the most commonly treated skin conditions."	( Kelleher, DK; Piazena, H, 2012)
"Actinic keratosis is a precursor to cutaneous squamous cell carcinoma."	( Cornelius, LA; Cunningham, TJ; Demehri, S; Eliane, JP; Kopan, R; Manivasagam, S; Mirzaalian, H; Saavedra, AP; Schaffer, A; Tabacchi, M; Tuchayi, SM; Turkoz, A; Wallendorf, M, 2017)
"Actinic keratosis is one of the most common skin diseases."	( Krutmann, J; Stege, H, 2017)
"Actinic keratosis is one of the most common disorder characterized by erythematic and generally attached scaly lesions which are present either alone or in clusters."	( Katare, OP; Sharma, G; Sharma, M; Singh, B, 2019)
"Actinic keratosis is the most frequent premalignant skin disease in the white population."	( Arits, AHMM; Essers, BAB; Jansen, MHE; Kelleners-Smeets, NWJ; Kessels, JPHM; Kouloubis, N; Mosterd, K; Nelemans, PJ; Quaedvlieg, PJF; Steijlen, PM; van Pelt, HPA, 2019)
"Actinic keratosis is a common skin disease that may progress to invasive squamous cell carcinoma if left untreated."	( Andrades, E; Gadea, A; Hernández-Muñoz, I; Nonell, L; Pujol, R; Sánchez, S; Segura, S; Toll, A, 2020)
"Actinic keratosis is caused by excessive lifetime sun exposure."	( Calzavara-Pinton, I; Calzavara-Pinton, P; Rossi, M; Rovati, C, 2022)
"Actinic keratosis is one of the most common dermatological disorders."	( Bianchi, L; Campione, E; Cosio, T; Di Prete, M; Di Raimondo, C; Diluvio, L; Gaeta Shumak, R; Garofalo, V; Geraci, F; Lambiase, S; Lanna, C; Lozzi, F, 2022)
"Actinic keratosis is an intraepithelial proliferation of atypical keratinocytes that could progress into invasive squamous cell carcinoma."	( Bianchi, L; Campione, E; Costanza, G; Di Prete, M; Di Raimondo, C; Dika, E; Franceschini, C; Garofalo, V; Mazzilli, S; Orlandi, A; Palumbo, V, 2022)
"Actinic keratosis is a pre-malignant skin disease caused by excessive exposure to ultraviolet light."	( Booth, L; Bordeaux, ZA; Dent, P; Kwatra, SG, 2023)
"Actinic keratosis is a lesion that develops in sun-exposed areas of the skin and is considered to be a precancerous condition or an early in situ squamous cell carcinoma."	( Bégeault, N; Delarue, A; Heppt, MV; Stockfleth, E, 2023)

Excerpt	Reference
"Actinic keratosis have a high risk of progression to a squamous cell carcinoma."	( Cartocci, A; Cinotti, E; Fiorani, D; Rubegni, P; Trovato, E, 2023)

Excerpt	Reference
"A number of effective treatments for actinic keratosis are available, including topical and lesion-directed therapies."	( Goldberg, DJ, 2010)
"During treatment of actinic keratosis (AK) lesions with imiquimod sub-clinical lesions often become visible."	( Duteil, L; Gupta, G; Mallefet, P; Ortonne, JP; Ortonne, N; Queille, C, 2010)
"Photodynamic therapy (PDT) for the treatment of actinic keratosis has been shown to be effective and safe in large clinical trials published in the last 5 years."	( Fernández-Guarino, M; Harto, A; Jaén, P, 2010)
"For an improved treatment of actinic keratosis and squamous cell carcinoma, inhibitors of human DNA polymerase alpha (pol alpha) are developed by docking nucleoside phosphonate diphosphates into the active site of pol alpha."	( Höltje, HD; Höltje, M; Korting, HC; Murruzzu, C; Natek, M; Reissig, HU; Schäfer-Korting, M; Schwanke, A; Zdrazil, B; Zuhse, R, 2010)
"Field therapy, the regional overall treatment of actinic keratosis which takes place on the same field, is made possible by external use of imiquimod cream."	( Idezuki, T, 2013)
"Aminolevulinic acid (ALA)-PDT for the treatment of actinic keratosis (AK) has been well studied in Europe and North America."	( Cai, H; Li, Q; Liu, W; Liu, XY; Qiao, L; Sun, P; Tian, R; Wang, YX; Yang, ZY, 2013)
"Cryosurgery is the most common treatment for actinic keratosis (AK) in the United States."	( Berman, B; Goldenberg, G; Goncalves, J; Hanke, CW; Knudsen, KM; Larsson, T; Skov, T; Swanson, N; Tyring, SK; Werschler, WP, 2014)
"Ingenol mebutate gel is a topical field treatment for actinic keratosis (AK) approved for a 2- or 3-day duration of application."	( Bettencourt, MS, 2014)
"The new target for the treatment of actinic keratosis (AK) is the detection and clearance of clinical and subclinical lesions across an entire sun-exposed field."	( Stockfleth, E, 2015)
"Ingenol mebutate gel is a topical field treatment of actinic keratosis (AK)."	( Haddican, M; Jim On, SC; Lebwohl, M; Singer, G; Yaroshinsky, A, 2015)
"Cryotherapy is the most common treatment for actinic keratosis, but its effect is limited to individual lesions."	( Abalde, MT; Batalla, A; de la Torre, C; Feal, C; Flórez, Á; Peón, G; Salgado-Boquete, L, 2015)
"In the future, the treatment of actinic keratosis can be more often done in primary health care."	( Isoherranen, K; Koskenmies, S; Overmark, M; Pitkänen, S; Saksela, O; Ylitalo, L, 2015)
"We report the successful use of PDT to treat actinic keratosis and skin cancers in two patients with BP, both of whom had excellent response to PDT and tolerated treatment without any bullous disease flares."	( Canavan, TN; de la Feld, SF; Huang, C; Sami, N, 2017)
"After 5-fluorouracil treatment, actinic keratosis was diagnosed in 45."	( Hirata, SH; Ishioka, P; Lellis, RF; Maia, M; Rodrigues, SB, 2018)
"Currently available topical treatments for actinic keratosis (AK) are associated with substantial side-effects."	( Chang, CH; Chi, CC; Hong, CH; Lai, FJ; Lan, CE; Lee, CH; Lin, SH; Lin, TK; Sheu, HM; Wong, TW; Wu, CH; Yang, CC; Yen, H, 2018)
"The cost of topical treatments for actinic keratosis (AK) has never been evaluated with respect to the actual cancerization field treated and the corresponding lesion response rate."	( Arisi, M; Calzavara-Pinton, P; Hamon, PA; Tanova, NT; Zane, C, 2018)
"Sequential treatment of actinic keratosis (AK) and cancerization field with cryotherapy and ingenol mebutate (IM) is widely used in clinical practice, however, the order of application of sequential treatment has not been examined yet."	( González, S; Pasquali, P; Segurado-Miravalles, G, 2018)
"The cost of topical treatments for actinic keratosis (AK) has historically been evaluated in relation to the number of lesions requiring treatment or simply by the price of a single tube/sachet of the drug used."	( Calzavara-Pinton, P; Hamon, P; Tanova, N, 2019)
"Photodynamic therapy is an effective treatment for actinic keratosis."	( Fu, C; Kuang, BH; Qin, L; Wang, BC; Zeng, XY, 2019)
"Current field-directed treatments of actinic keratosis (AK), a pre-malignant condition, are often limited by severe local reactions and/or complex treatment."	( Cutler, D; Cutler, E; DuBois, J; Fang, J; Forman, S; Kempers, S; Kwan, R; Poon, A; Wang, H, 2020)
"Current clinical uses include treatment of actinic keratosis, superficial basal cell carcinomas, and acne."	( Aebisher, D; Bartusik-Aebisher, D; Dynarowicz, K; Koziorowska, K; Mazur, A, 2022)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	87 (8.56)	23.3326
1990's	0 (0.00)	12.5806
2000's	54 (5.31)	18.1394
2010's	641 (63.09)	28.8240
2020's	234 (23.03)	9.53

Drug	Relationship Strength	Studies	Trials
adenine	low	1	0
quinacrine	low	1	0
lactic acid	low	2	0
dimethyl sulfoxide	low	1	0
glycolic acid	low	2	0
indoleacetic acid	medium	1	1
iodine	low	3	0
croton oil	low	2	0
nitrous oxide	low	1	0
purine	low	1	0
pyridoxine	low	1	0
pyruvic acid	low	1	0
urea	low	2	0
azathioprine	low	2	0
cetirizine	medium	1	1
chloroquine	low	1	0
clioquinol	low	2	0
eflornithine	medium	3	2
hydroxyurea	low	7	0
hypericin	low	1	0
2-propanol	low	1	0
khellin	low	2	0
meclizine	low	1	0
methoxsalen	low	1	0
oxybutynin	low	3	0
aminosalicylic acid	low	1	0
propranolol	low	1	0
protoporphyrin ix	medium	29	13
tazarotene	medium	2	1
tetracaine	medium	1	1
triclosan	low	1	0
hydrocortisone acetate	low	1	0
thymidine	low	1	0
prednisone	low	2	0
glutamine	low	1	0
9,10-dimethyl-1,2-benzanthracene	low	2	0
colchicine	medium	6	1
fluocinolone acetonide	low	1	0
triaziquone	low	1	0
histidine	low	1	0
ethyl chloride	low	2	0
dichlorodifluoromethane	low	1	0
trichloroacetic acid	medium	4	1
4-butyrolactone	medium	1	1
pyrrolidonecarboxylic acid	low	1	0
pyrroles	low	1	0
benzoin	low	1	0
catechin	low	2	0
perylene	low	1	0
acridines	low	1	0
cyclopentane	low	1	0
pirinitramide	medium	1	1
betamethasone	low	1	0
podophyllotoxin	low	1	0
n-hexadecane	low	2	0
gentian violet	low	1	0
isovanillin	low	1	0
deoxycytidine	low	2	0
potassium hydroxide	medium	2	1
d-alpha tocopherol	medium	1	1
streptomycin	low	2	0
floxacillin	low	1	0
manganese	low	1	0
thulium	medium	1	1
chromium	low	1	0
erbium	low	1	0
zinc sulfate	low	1	0
hexamethyldisiloxane	low	1	0
trolamine salicylate	low	3	0
tetradecanoylphorbol acetate	low	1	0
phenyl acetate	low	1	0
triamcinolone	medium	1	1
pirfenidone	low	1	0
simvastatin	medium	1	1
itraconazole	low	1	0
capecitabine	low	5	0
trazodone hydrochloride	low	1	0
glutathione disulfide	low	1	0
methyl levulinate	medium	1	1
voriconazole	low	4	0
betulin	medium	2	2
fluocinolone	low	1	0
pyrimidine dimers	medium	1	1
vitamin b 6	low	1	0
1-hexadecyl-2-acetyl-glycero-3-phosphocholine	low	1	0
imatinib mesylate	low	1	0
methotrexate	low	2	0
docetaxel anhydrous	low	1	0
beta-solamarine	medium	1	1
organophosphonates	low	1	0
firocoxib	medium	1	1
sorafenib	low	1	0
deoxycholic acid	low	1	0
cortisone	low	3	0
carboplatin	low	2	0
glucosamine	low	1	0
elastin	low	1	0
inositol 3-phosphate	low	6	0
mometasone furoate	low	1	0
retinol	low	21	0
tacrolimus	low	4	0
keratan sulfate	low	1	0
lycopene	low	1	0
valrubicin	low	1	0
aphidicolin	low	1	0
dipyrone	medium	1	1
bromochloroacetic acid	low	5	0
s 1033	low	1	0
urocanic acid	low	3	0
curcumin	low	1	0
sulindac	low	1	0
fusidic acid	low	1	0
dasatinib	low	1	0
calcitriol	medium	13	6
harmine	low	1	0
genistein	low	1	0
astragalin	low	1	0
phenylephrine hydrochloride	low	4	0
acitretin	low	5	0
sirolimus	low	1	0
clobetasol	medium	9	4
ag-490	low	1	0
su 11248	low	1	0
12-hydroxy-5,8,10,14-eicosatetraenoic acid	low	1	0
arsenic	low	15	0
sulfur	low	1	0
octa-2,4,6-trienoic acid	medium	1	1
5-aminolevulinic acid hexyl ester	medium	2	1
mart-1 antigen	low	4	0
bibw 2992	low	1	0
2-amino-5-hydroxy-4-oxopentanoic acid	low	1	0
brimonidine tartrate	medium	1	1
trametinib	low	2	0
dactolisib	low	1	0
podophyllin	low	2	0
gdc-0973	low	1	0
sodium salicylate	low	1	0
chitosan	low	1	0
calcium dobesilate monopotassium salt	medium	1	1
sodium ethylxanthate	low	1	0
methyl jasmonate	low	1	0
lde225	low	1	0
gdc 0449	low	3	0
incb-018424	low	1	0
plx4032	low	2	0
elafin	medium	1	1
piperidines	low	1	0
interleukin-8	low	2	0
dabrafenib	low	2	0
calcipotriene	medium	11	6
heme	medium	1	1
chondroitin	low	1	0
salicylates	low	2	0
dicumarol	low	1	0
piroxicam	medium	6	3
transforming growth factor beta	low	3	0
rome	medium	2	1
1 alpha,24-dihydroxyvitamin d3	medium	1	1
cyclosporine	low	2	0
pemetrexed	low	1	0
eye	low	1	0
metallothionein	low	1	0
pyrimidinones	low	2	0

Protein Targets (1,783)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	28	0	0	28
Chain A, Cruzipain	14	0	0	14
regulator of G-protein signaling 4	14	0	0	14
Platelet-activating factor receptor	0	2	0	2
Inositol monophosphatase 1	4	0	0	4
hypoxia-inducible factor 1 alpha subunit	19	0	0	19
RAR-related orphan receptor gamma	44	0	0	44
GLI family zinc finger 3	42	0	0	42
AR protein	62	0	0	62
aldehyde dehydrogenase 1 family, member A1	35	0	0	35
retinoic acid nuclear receptor alpha variant 1	44	0	0	44
retinoid X nuclear receptor alpha	40	0	0	40
estrogen nuclear receptor alpha	65	0	0	65
peroxisome proliferator-activated receptor delta	31	0	0	31
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	36	0	0	36
activating transcription factor 6	21	0	0	21
v-jun sarcoma virus 17 oncogene homolog (avian)	20	0	0	20
Histone H2A.x	20	0	0	20
thyroid hormone receptor beta isoform a	15	0	0	15
heat shock protein beta-1	20	0	0	20
nuclear factor erythroid 2-related factor 2 isoform 1	49	0	0	49
lamin isoform A-delta10	34	0	0	34
Voltage-dependent calcium channel gamma-2 subunit	24	0	0	24
Glutamate receptor 2	25	0	0	25
nuclear receptor subfamily 1, group I, member 3	35	0	0	35
estrogen-related nuclear receptor alpha	47	0	0	47
pregnane X nuclear receptor	43	0	0	43
Chain A, Beta-lactamase	13	0	0	13
Chain A, HADH2 protein	15	0	0	15
Chain B, HADH2 protein	15	0	0	15
Chain A, JmjC domain-containing histone demethylation protein 3A	9	0	0	9
Luciferase	21	0	0	21
acid sphingomyelinase	5	0	0	5
pregnane X receptor	12	0	0	12
SMAD family member 2	17	0	0	17
ATAD5 protein, partial	17	0	0	17
SMAD family member 3	17	0	0	17
TDP1 protein	57	0	0	57
apical membrane antigen 1, AMA1	5	0	0	5
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	15	0	0	15
thyroid stimulating hormone receptor	13	0	0	13
estrogen receptor 2 (ER beta)	24	0	0	24
progesterone receptor	25	0	0	25
glucocorticoid receptor [Homo sapiens]	44	0	0	44
farnesoid X nuclear receptor	29	0	0	29
glucocerebrosidase	7	0	0	7
bromodomain adjacent to zinc finger domain 2B	8	0	0	8
P53	3	0	0	3
peroxisome proliferator activated receptor gamma	32	0	0	32
vitamin D (1,25- dihydroxyvitamin D3) receptor	33	0	0	33
IDH1	22	0	0	22
euchromatic histone-lysine N-methyltransferase 2	49	0	0	49
aryl hydrocarbon receptor	23	0	0	23
thyroid stimulating hormone receptor	20	0	0	20
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	14	0	0	14
Caspase-7	9	0	0	9
serine-protein kinase ATM isoform a	1	0	0	1
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	19	0	0	19
chromobox protein homolog 1	26	0	0	26
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	12	0	0	12
caspase-3	9	0	0	9
thyroid hormone receptor beta isoform 2	38	0	0	38
mitogen-activated protein kinase 1	16	0	0	16
nuclear factor NF-kappa-B p105 subunit isoform 1	4	0	0	4
ras-related protein Rab-9A	7	0	0	7
urokinase-type plasminogen activator precursor	10	0	0	10
plasminogen precursor	10	0	0	10
urokinase plasminogen activator surface receptor precursor	10	0	0	10
nuclear receptor ROR-gamma isoform 1	19	0	0	19
lethal(3)malignant brain tumor-like protein 1 isoform I	2	0	0	2
geminin	53	0	0	53
cytochrome P450 3A4 isoform 1	24	0	0	24
caspase-1 isoform alpha precursor	4	0	0	4
Gamma-aminobutyric acid receptor subunit pi	24	2	1	27
Cellular tumor antigen p53	36	0	0	36
Gamma-aminobutyric acid receptor subunit beta-1	24	2	1	27
Gamma-aminobutyric acid receptor subunit delta	24	2	1	27
Gamma-aminobutyric acid receptor subunit gamma-2	24	2	1	27
Gamma-aminobutyric acid receptor subunit alpha-5	24	2	1	27
Gamma-aminobutyric acid receptor subunit alpha-3	24	2	1	27
Gamma-aminobutyric acid receptor subunit gamma-1	24	2	1	27
Gamma-aminobutyric acid receptor subunit alpha-2	24	2	1	27
Gamma-aminobutyric acid receptor subunit alpha-4	24	2	1	27
Gamma-aminobutyric acid receptor subunit gamma-3	24	2	1	27
Gamma-aminobutyric acid receptor subunit alpha-6	24	2	1	27
Nuclear receptor ROR-gamma	14	2	2	18
Caspase-7	3	0	0	3
Gamma-aminobutyric acid receptor subunit alpha-1	24	4	1	29
Gamma-aminobutyric acid receptor subunit beta-3	24	2	1	27
Gamma-aminobutyric acid receptor subunit beta-2	24	2	1	27
GABA theta subunit	24	2	1	27
ATPase family AAA domain-containing protein 5	24	0	0	24
Ataxin-2	27	0	0	27
Gamma-aminobutyric acid receptor subunit epsilon	24	2	1	27
USP1 protein, partial	28	0	0	28
Microtubule-associated protein tau	26	0	0	27
vitamin D3 receptor isoform VDRA	20	0	0	20
flap endonuclease 1	21	0	0	21
serine/threonine-protein kinase PLK1	6	0	0	6
eyes absent homolog 2 isoform a	1	0	0	1
DNA polymerase eta isoform 1	6	0	0	6
peripheral myelin protein 22	25	0	0	25
survival motor neuron protein isoform d	18	0	0	18
histone acetyltransferase KAT2A isoform 1	16	0	0	16
ATP-binding cassette sub-family C member 3	0	33	0	33
Multidrug resistance-associated protein 4	0	33	0	34
Bile salt export pump	0	12	0	12
Bile salt export pump	0	47	0	47
Rap guanine nucleotide exchange factor 3	6	0	0	6
Rap guanine nucleotide exchange factor 4	3	0	0	3
Chain A, Ferritin light chain	18	0	0	18
thioredoxin reductase	31	0	0	31
Smad3	18	0	0	18
alpha-galactosidase	4	0	0	4
DNA polymerase iota isoform a (long)	21	0	0	21
DNA topoisomerase 2-alpha	0	1	11	13
Acetylcholinesterase	0	8	0	8
Chain A, MTA/SAH nucleosidase	0	1	0	1
Chain A, Ribosome-inactivating protein alpha-trichosanthin	0	0	1	1
Chain A, Ricin A chain	0	0	1	1
Chain A, Ribosome-inactivating protein 3	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
cytochrome P450 family 3 subfamily A polypeptide 4	36	0	0	36
nuclear factor erythroid 2-related factor 2 isoform 2	18	0	0	18
importin subunit beta-1 isoform 1	12	0	0	12
snurportin-1	12	0	0	12
tumor susceptibility gene 101 protein	4	0	0	4
GTP-binding nuclear protein Ran isoform 1	9	0	0	9
Cyclin-dependent kinase 1	0	3	13	16
Heat shock protein HSP 90-beta	0	1	0	1
Xanthine dehydrogenase/oxidase	0	4	0	4
TAR DNA-binding protein 43	12	0	0	12
Protein mono-ADP-ribosyltransferase PARP15	0	2	0	2
Leucine-rich repeat serine/threonine-protein kinase 2	0	3	6	9
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	14	0	0	14
Chain A, 2-oxoglutarate Oxygenase	21	0	0	21
Chain A, ATP-DEPENDENT DNA HELICASE Q1	8	0	0	8
endonuclease IV	4	0	0	4
15-lipoxygenase, partial	11	0	0	11
WRN	2	0	0	2
chaperonin-containing TCP-1 beta subunit homolog	2	0	0	2
phosphopantetheinyl transferase	15	0	0	15
NFKB1 protein, partial	5	0	0	5
GLS protein	19	0	0	19
Thrombopoietin	4	0	0	4
nonstructural protein 1	5	0	0	5
NPYLR7B	0	0	2	2
arylsulfatase A	14	0	0	14
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	6	0	0	6
Bloom syndrome protein isoform 1	18	0	0	18
peripheral myelin protein 22 isoform 1	11	0	0	11
cellular tumor antigen p53 isoform a	12	0	0	12
polyunsaturated fatty acid lipoxygenase ALOX12	7	0	0	7
cytochrome P450 2C19 precursor	9	0	0	9
cytochrome P450 2C9 precursor	7	0	0	7
potassium voltage-gated channel subfamily H member 2 isoform d	15	0	0	15
serine/threonine-protein kinase mTOR isoform 1	6	0	0	6
histone-lysine N-methyltransferase 2A isoform 2 precursor	7	0	0	7
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	7	0	0	7
DNA polymerase kappa isoform 1	18	0	0	18
M-phase phosphoprotein 8	8	0	0	8
muscarinic acetylcholine receptor M1	8	0	0	8
lethal factor (plasmid)	12	0	0	12
pyruvate kinase PKM isoform b	2	0	0	2
Polyunsaturated fatty acid lipoxygenase ALOX15B	7	0	0	7
Tyrosine-protein kinase JAK2	0	3	12	15
Epidermal growth factor receptor	0	12	14	26
Receptor tyrosine-protein kinase erbB-2	0	5	7	12
Ornithine decarboxylase	2	1	0	4
Tyrosine-protein kinase JAK1	0	3	14	17
Glutamate receptor ionotropic, NMDA 1	0	1	0	2
Histamine H2 receptor	12	0	0	12
Tyrosine-protein kinase JAK3	0	4	6	10
Glutamate receptor ionotropic, NMDA 2A	0	1	0	2
Glutamate receptor ionotropic, NMDA 2B	0	2	0	4
Glutamate receptor ionotropic, NMDA 2C	0	1	0	2
Tyrosyl-DNA phosphodiesterase 1	0	1	0	1
ATP-dependent phosphofructokinase	14	0	0	14
large T antigen	0	2	0	2
Gamma-aminobutyric acid receptor subunit rho-1	0	1	0	1
Glutamate receptor 1	0	1	0	1
Glutamate receptor 2	0	1	0	1
Glutamate receptor 3	0	1	0	1
Glutamate receptor ionotropic, kainate 3	1	1	0	2
Solute carrier family 15 member 1	0	2	0	2
Glutamate receptor 4	0	1	0	1
Solute carrier family 15 member 1	0	1	0	1
Solute carrier family 15 member 2	0	1	0	1
thioredoxin glutathione reductase	11	0	0	11
microphthalmia-associated transcription factor isoform 9	0	1	0	1
Carbonic anhydrase 1	0	15	0	20
Carbonic anhydrase 2	0	16	1	23
Tyrosine-protein phosphatase non-receptor type 1	0	1	1	4
huntingtin isoform 2	7	0	0	7
DNA polymerase catalytic subunit	0	1	0	1
DNA polymerase catalytic subunit	0	1	0	1
DNA polymerase beta	0	1	0	1
DNA polymerase beta	0	1	0	1
DNA polymerase catalytic subunit	0	1	0	1
DNA polymerase catalytic subunit	0	1	0	1
DNA polymerase alpha catalytic subunit	0	1	1	2
DNA polymerase delta catalytic subunit	0	1	0	1
DNA polymerase catalytic subunit	0	1	0	1
DNA polymerase subunit gamma-1	0	1	0	1
DNA polymerase lambda	0	1	0	1
Chain A, Hyaluronidase, phage associated	0	1	0	1
acetylcholinesterase	18	0	0	18
Polyphenol oxidase 2	0	3	1	5
Pancreatic alpha-amylase	0	2	0	2
Albumin	0	1	0	1
Urease	0	2	0	2
Prolyl 4-hydroxylase subunit alpha-1	0	0	0	1
Tyrosinase	0	2	0	2
Alpha-2B adrenergic receptor	0	10	2	13
Spike glycoprotein	23	1	2	26
Hyaluronate lyase	0	1	0	1
Prolyl hydroxylase EGLN2	0	0	0	1
Egl nine homolog 1	0	0	0	1
Prolyl hydroxylase EGLN3	0	0	0	1
Hypoxia-inducible factor 1-alpha inhibitor	0	0	0	1
Solute carrier family 23 member 1	0	1	0	1
Chain A, Phospholipase A2 isoform 3	0	0	1	1
GTP-binding protein (rab7)	0	0	2	2
ras protein, partial	0	0	2	2
interleukin 8	8	0	0	8
hypothetical protein, conserved	2	0	0	2
EWS/FLI fusion protein	29	0	0	30
cytochrome P450 2D6	16	0	0	16
Rac1 protein	0	0	2	2
cell division cycle 42 (GTP binding protein, 25kDa), partial	0	0	2	2
Prostaglandin-H2 D-isomerase	0	1	0	1
Solute carrier family 22 member 6	0	4	0	4
Prostaglandin G/H synthase 1	0	5	0	5
Prostaglandin G/H synthase 2	0	3	0	3
Fatty acid-binding protein, liver	0	2	0	2
Integrin beta-3	9	2	0	11
Myeloperoxidase	0	1	0	1
Prostaglandin G/H synthase 1	0	7	1	8
Seed linoleate 13S-lipoxygenase-1	0	2	0	2
Integrin alpha-IIb	9	1	0	10
Glutathione hydrolase 1 proenzyme	0	1	0	1
Prostaglandin G/H synthase 1	0	9	0	10
Adenosine receptor A1	0	3	0	4
Adenosine receptor A2a	0	3	0	4
Substance-P receptor	0	2	0	2
Prostaglandin G/H synthase 2	0	11	7	19
Urotensin-2 receptor	0	2	0	2
4-aminobutyrate aminotransferase, mitochondrial	0	1	0	1
Ras-related protein Rab-2A	0	0	2	2
Prostaglandin G/H synthase 2	0	5	0	5
Rho-associated protein kinase 2	0	1	0	1
Nicotinate phosphoribosyltransferase	0	2	0	2
Solute carrier family 22 member 20	0	4	0	4
Solute carrier family 22 member 6	0	4	0	4
Canalicular multispecific organic anion transporter 1	0	30	0	30
Sigma non-opioid intracellular receptor 1	0	7	1	8
Sigma non-opioid intracellular receptor 1	0	0	1	1
Chain A, BCL-2-RELATED PROTEIN A1	0	0	1	1
Genome polyprotein	0	1	0	1
Prolyl 4-hydroxylase, beta polypeptide	0	0	0	1
Neuraminidase	0	3	1	4
dual specificity tyrosine-phosphorylation-regulated kinase 1A	0	0	0	1
glycogen synthase kinase-3 alpha	0	0	0	1
bcl-2-like protein 11 isoform 1	0	0	1	1
Carbonic anhydrase 12	0	6	0	9
Pancreatic triacylglycerol lipase	0	3	0	3
Glycoprotein hormones alpha chain	1	0	0	1
Aldo-keto reductase family 1 member B1	0	8	0	8
Sialidase	0	2	0	2
Aldo-keto reductase family 1 member B1	0	5	0	5
Carbonic anhydrase 4	0	8	0	11
Bifunctional epoxide hydrolase 2	0	4	0	4
Carbonic anhydrase 7	0	7	0	10
Fumarate hydratase	16	0	0	16
G	22	0	0	22
polyprotein	16	0	0	16
hemoglobin subunit beta	3	0	0	3
muscleblind-like protein 1 isoform 1	9	0	0	9
Interferon beta	36	0	0	36
HLA class I histocompatibility antigen, B alpha chain	22	0	0	22
Inositol hexakisphosphate kinase 1	22	0	0	22
Protein-arginine deiminase type-4	0	4	0	4
cytochrome P450 2C9, partial	22	0	0	22
Cocaine esterase	0	1	0	1
Coagulation factor XII	0	1	0	1
Cholinesterase	0	3	0	3
Liver carboxylesterase 1	0	1	0	1
Liver carboxylesterase 1	0	1	0	2
Sodium-dependent dopamine transporter	0	2	0	2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	0	5	7	12
nuclear receptor subfamily 1, group I, member 2	12	0	0	12
galanin receptor type 3	0	1	0	1
Glucocorticoid receptor	0	12	1	14
Glycine receptor subunit alpha-1	0	10	0	10
Glycine receptor subunit beta	0	10	0	10
Glycine receptor subunit alpha-2	0	10	0	10
Glycine receptor subunit alpha-3	0	10	0	10
ORF73	0	0	1	1
Glycogen phosphorylase, muscle form	0	1	0	1
Pancreatic alpha-amylase	0	1	0	1
Protein kinase C beta type	0	3	15	18
5'-nucleotidase	0	1	0	1
Ectonucleoside triphosphate diphosphohydrolase 1	0	1	0	1
Protein kinase C epsilon type	0	3	8	11
Transcription factor p65	0	1	0	1
Sodium/bile acid cotransporter	0	3	1	4
5'-nucleotidase	0	1	0	1
G-protein coupled bile acid receptor 1	0	0	2	2
Leukotriene C4 synthase	0	0	6	6
PPM1D protein	18	0	0	18
Bone morphogenetic protein receptor type-1B	0	0	13	13
Membrane-associated progesterone receptor component 1	0	0	11	11
Cell division cycle 7-related protein kinase	0	0	8	8
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	0	4	7	11
Serine/threonine-protein kinase PLK4	0	2	13	15
Serine/threonine-protein kinase 25	0	0	6	6
ATP-dependent RNA helicase DDX3X	0	0	13	13
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta	0	1	6	7
Pyridoxal kinase	0	0	13	14
Citron Rho-interacting kinase	0	0	13	13
Serine/threonine-protein kinase RIO3	0	0	6	6
Dual specificity mitogen-activated protein kinase kinase 7	0	0	6	6
Serine/threonine-protein kinase Chk1	0	1	13	14
Inhibitor of nuclear factor kappa-B kinase subunit beta	0	1	6	8
Peripheral plasma membrane protein CASK	0	0	6	6
Aurora kinase A	0	3	13	16
Cyclin-G-associated kinase	0	1	13	14
Serine/threonine-protein kinase DCLK1	0	0	6	6
Inhibitor of nuclear factor kappa-B kinase subunit alpha	0	1	6	7
Muscle, skeletal receptor tyrosine-protein kinase	0	0	6	6
Ephrin type-B receptor 6	0	0	13	13
Peroxisomal acyl-coenzyme A oxidase 3	0	0	13	13
Mitogen-activated protein kinase 13	0	1	6	7
3-phosphoinositide-dependent protein kinase 1	0	1	6	7
Mitogen-activated protein kinase kinase kinase 13	0	0	6	6
Death-associated protein kinase 3	0	0	6	6
Mitogen-activated protein kinase kinase kinase 7	0	0	6	6
Receptor-interacting serine/threonine-protein kinase 2	0	4	13	17
Mitotic checkpoint serine/threonine-protein kinase BUB1	0	0	13	13
NUAK family SNF1-like kinase 1	0	1	6	7
Dynamin-like 120 kDa protein, mitochondrial	0	0	13	13
Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma	0	0	6	6
Rho-associated protein kinase 2	0	0	13	13
Serine/threonine-protein kinase ULK1	0	0	13	13
Serine/threonine-protein kinase/endoribonuclease IRE1	0	0	13	13
Ribosomal protein S6 kinase alpha-5	0	0	13	13
U5 small nuclear ribonucleoprotein 200 kDa helicase	0	0	13	13
Ribosomal protein S6 kinase alpha-4	0	0	13	13
Serine/threonine-protein kinase 16	0	0	13	13
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	0	0	6	6
Serine/threonine-protein kinase PAK 3	0	0	6	6
Cyclin-dependent kinase-like 5	0	0	10	10
Serine/threonine-protein kinase 17B	0	0	6	6
Serine/threonine-protein kinase 10	0	0	13	13
Serine/threonine-protein kinase D3	0	1	15	16
Cyclin-dependent kinase 14	0	0	6	6
Structural maintenance of chromosomes protein 2	0	0	13	13
Mitogen-activated protein kinase kinase kinase 6	0	0	13	13
Serine/threonine-protein kinase OSR1	0	0	6	6
Mitogen-activated protein kinase kinase kinase kinase 4	0	0	13	13
Serine/threonine-protein kinase LATS1	0	0	13	13
Serine/threonine-protein kinase PAK 4	0	2	13	15
Serine/threonine-protein kinase Chk2	0	1	6	7
Tyrosine-protein kinase ABL1	0	14	17	32
RAF proto-oncogene serine/threonine-protein kinase	0	7	7	16
High affinity nerve growth factor receptor	0	0	12	12
Guanine nucleotide-binding protein G(i) subunit alpha-2	0	0	8	8
ADP/ATP translocase 2	0	0	13	13
Cytochrome P450 1A2	0	10	1	12
Cytochrome P450 2E1	0	2	0	2
Insulin receptor	0	3	13	16
Tyrosine-protein kinase Lck	0	8	13	21
Tyrosine-protein kinase Fyn	0	6	13	19
Glycogen phosphorylase, liver form	0	0	13	13
Tyrosine-protein kinase Fes/Fps	0	0	13	13
Macrophage colony-stimulating factor 1 receptor	0	5	6	11
Adenine phosphoribosyltransferase	0	0	10	10
Tyrosine-protein kinase Yes	0	1	13	14
Tyrosine-protein kinase Lyn	0	4	13	17
Proto-oncogene tyrosine-protein kinase receptor Ret	0	5	13	18
Insulin-like growth factor 1 receptor	0	2	13	15
Signal recognition particle receptor subunit alpha	0	0	10	10
Cytochrome c1, heme protein, mitochondrial	0	0	13	13
Hepatocyte growth factor receptor	0	2	13	15
Tyrosine-protein kinase HCK	0	5	13	18
Proto-oncogene tyrosine-protein kinase ROS	0	0	6	6
Platelet-derived growth factor receptor beta	0	8	13	21
Tyrosine-protein kinase Fgr	0	0	11	11
Wee1-like protein kinase 2	0	0	6	6
Uncharacterized serine/threonine-protein kinase SBK3	0	0	6	6
Serine/threonine-protein kinase A-Raf	0	3	13	16
Cytochrome P450 2C8	0	2	0	3
Mast/stem cell growth factor receptor Kit	0	8	7	15
Glycogen phosphorylase, brain form	0	0	13	13
Breakpoint cluster region protein	0	7	16	24
Serine/threonine-protein kinase pim-1	0	2	13	15
Fibroblast growth factor receptor 1	0	5	13	18
Cyclin-dependent kinase 4	0	2	13	15
ADP/ATP translocase 3	0	0	13	13
Inosine-5'-monophosphate dehydrogenase 2	0	0	13	13
Proto-oncogene tyrosine-protein kinase Src	0	12	13	25
cAMP-dependent protein kinase type II-alpha regulatory subunit	0	0	13	13
Insulin receptor-related protein	0	0	6	6
Serine/threonine-protein kinase B-raf	0	6	16	24
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform	0	0	13	13
Ribosyldihydronicotinamide dehydrogenase [quinone]	0	2	13	15
Platelet-derived growth factor receptor alpha	0	8	7	15
Tyrosine-protein kinase Fer	0	0	13	13
Protein kinase C alpha type	0	4	15	19
cAMP-dependent protein kinase catalytic subunit alpha	0	1	13	14
Vascular endothelial growth factor receptor 1	0	4	6	10
General transcription and DNA repair factor IIH helicase subunit XPD	0	0	13	13
Interferon-induced, double-stranded RNA-activated protein kinase	0	0	6	6
Casein kinase II subunit alpha'	0	0	13	13
Ras-related protein Rab-6A	0	0	12	12
Serine/threonine-protein kinase MAK	0	0	6	6
Cyclin-dependent kinase 11B	0	0	6	6
Ephrin type-A receptor 1	0	0	13	13
Fibroblast growth factor receptor 2	0	0	6	6
Receptor tyrosine-protein kinase erbB-3	0	1	6	7
Multifunctional protein ADE2	0	0	13	13
Fibroblast growth factor receptor 4	0	0	6	6
Fibroblast growth factor receptor 3	0	0	6	6
cAMP-dependent protein kinase catalytic subunit gamma	0	0	10	10
cAMP-dependent protein kinase catalytic subunit beta	0	0	13	13
Ferrochelatase, mitochondrial	0	0	14	14
Ribosomal protein S6 kinase beta-1	0	0	11	11
Protein kinase C eta type	0	1	8	9
Cyclin-dependent kinase 2	0	4	14	18
Beta-adrenergic receptor kinase 1	0	0	13	13
Probable ATP-dependent RNA helicase DDX6	0	0	13	13
Activin receptor type-2A	0	0	6	6
Mitogen-activated protein kinase 3	0	1	13	14
MAP/microtubule affinity-regulating kinase 3	0	0	13	13
Deoxycytidine kinase	0	0	13	14
Mitogen-activated protein kinase 1	0	4	13	17
Ephrin type-A receptor 2	0	3	13	16
Ephrin type-A receptor 3	0	0	6	6
Ephrin type-A receptor 8	0	0	6	6
Ephrin type-B receptor 2	0	1	13	14
Leukocyte tyrosine kinase receptor	0	0	6	6
Non-receptor tyrosine-protein kinase TYK2	0	2	14	16
Phosphatidylethanolamine-binding protein 1	0	0	12	12
Wee1-like protein kinase	0	0	13	13
Heme oxygenase 2	0	0	13	13
Tyrosine-protein kinase receptor UFO	0	1	6	7
Mitogen-activated protein kinase 4	0	0	6	6
S-adenosylmethionine synthase isoform type-2	0	0	13	13
DnaJ homolog subfamily A member 1	0	0	13	13
RAC-alpha serine/threonine-protein kinase	0	3	13	16
RAC-beta serine/threonine-protein kinase	0	1	13	14
G protein-coupled receptor kinase 4	0	0	6	6
Cytochrome P450 2C19	0	12	1	13
Dual specificity protein kinase TTK	0	0	10	10
DNA replication licensing factor MCM4	0	0	13	13
Myosin-10	0	0	11	11
Tyrosine-protein kinase receptor Tie-1	0	0	6	6
Vascular endothelial growth factor receptor 3	0	3	6	9
Vascular endothelial growth factor receptor 2	0	8	7	16
Dual specificity mitogen-activated protein kinase kinase 2	0	5	13	18
Receptor-type tyrosine-protein kinase FLT3	0	5	13	19
Bone morphogenetic protein receptor type-1A	0	0	13	13
Activin receptor type-1B	0	0	13	13
TGF-beta receptor type-1	0	1	13	14
Serine/threonine-protein kinase receptor R3	0	0	10	10
TGF-beta receptor type-2	0	0	13	13
Electron transfer flavoprotein subunit beta	0	0	12	12
Tyrosine-protein kinase CSK	0	2	13	15
Glycine--tRNA ligase	0	0	13	13
Protein kinase C iota type	0	1	15	16
Exosome RNA helicase MTR4	0	0	13	13
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0	4	7	11
Serine/threonine-protein kinase mTOR	0	8	7	15
Megakaryocyte-associated tyrosine-protein kinase	0	0	6	6
Tyrosine-protein kinase Tec	0	1	13	14
Tyrosine-protein kinase TXK	0	1	6	7
Tyrosine-protein kinase ABL2	0	1	13	14
Tyrosine-protein kinase FRK	0	0	13	13
Tyrosine-protein kinase ZAP-70	0	0	6	6
Tyrosine-protein kinase SYK	0	2	13	15
26S proteasome regulatory subunit 6B	0	0	13	13
Mitogen-activated protein kinase 8	0	0	13	13
Mitogen-activated protein kinase 9	0	0	13	13
Dual specificity mitogen-activated protein kinase kinase 4	0	1	11	12
Dual specificity mitogen-activated protein kinase kinase 3	0	0	13	13
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha	0	0	12	12
Casein kinase I isoform alpha	0	3	13	16
Casein kinase I isoform delta	0	1	13	14
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	0	4	7	11
MAP kinase-activated protein kinase 2	0	1	13	14
Cyclin-dependent kinase 8	0	1	6	7
Elongation factor Tu, mitochondrial	0	0	13	13
Choline-phosphate cytidylyltransferase A	0	0	9	9
Cysteine--tRNA ligase, cytoplasmic	0	0	13	13
Casein kinase I isoform epsilon	0	1	13	14
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial	0	0	13	13
Dual specificity protein kinase CLK1	0	1	13	14
Dual specificity protein kinase CLK2	0	0	13	13
Dual specificity protein kinase CLK3	0	0	10	10
Glycogen synthase kinase-3 alpha	0	1	13	14
Glycogen synthase kinase-3 beta	0	3	13	16
Cyclin-dependent kinase 7	0	1	13	14
Cyclin-dependent kinase 9	0	1	13	14
Ras-related protein Rab-27A	0	0	13	13
Tyrosine-protein kinase Blk	0	2	6	8
Interleukin-1 receptor-associated kinase 1	0	0	13	13
Ribosomal protein S6 kinase alpha-3	0	2	13	15
Cytoplasmic tyrosine-protein kinase BMX	0	1	6	7
cAMP-dependent protein kinase catalytic subunit PRKX	0	0	6	6
Serine/threonine-protein kinase Nek2	0	1	13	14
Serine/threonine-protein kinase Nek3	0	0	13	13
Serine/threonine-protein kinase Nek4	0	0	6	6
Dual specificity mitogen-activated protein kinase kinase 6	0	0	13	13
Serine/threonine-protein kinase PLK1	0	3	12	15
Death-associated protein kinase 1	0	2	6	8
Dipeptidyl peptidase 1	0	1	0	1
LIM domain kinase 1	0	1	13	14
LIM domain kinase 2	0	1	13	14
Mitogen-activated protein kinase 12	0	1	6	7
Mitogen-activated protein kinase 10	0	1	12	13
Tyrosine--tRNA ligase, cytoplasmic	0	0	13	13
5'-AMP-activated protein kinase subunit gamma-1	0	0	13	14
5'-AMP-activated protein kinase catalytic subunit alpha-2	0	1	6	8
Ephrin type-B receptor 3	0	0	13	13
Ephrin type-A receptor 5	0	0	13	13
Ephrin type-B receptor 4	0	3	13	16
Ephrin type-B receptor 1	0	0	6	6
Ephrin type-A receptor 4	0	0	13	13
Adenylate kinase 2, mitochondrial	0	0	13	13
Adenosine kinase	0	0	12	12
Hormonally up-regulated neu tumor-associated kinase	0	0	6	6
Serine/threonine-protein kinase SIK1	0	2	6	8
Receptor-interacting serine/threonine-protein kinase 4	0	0	6	6
Ras-related protein Rab-10	0	0	13	13
Cell division control protein 2 homolog	0	0	6	6
Actin-related protein 3	0	1	13	14
Actin-related protein 2	0	0	12	12
Calcium-dependent protein kinase 1	0	0	6	6
GTP-binding nuclear protein Ran	0	0	13	13
Casein kinase II subunit alpha	0	0	6	6
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta	0	0	6	6
SRSF protein kinase 2	0	0	6	6
Casein kinase I isoform gamma-2	0	0	12	12
Mitogen-activated protein kinase kinase kinase 9	0	0	6	6
Serine/threonine-protein kinase PknB	0	0	6	6
Cyclin-dependent kinase 3	0	0	11	11
Cyclin-dependent kinase-like 1	0	0	6	6
Cyclin-dependent kinase 6	0	1	13	14
Cyclin-dependent-like kinase 5	0	1	13	14
Cyclin-dependent kinase 16	0	0	13	13
Cyclin-dependent kinase 17	0	0	13	13
Dual specificity mitogen-activated protein kinase kinase 1	0	6	13	19
Angiopoietin-1 receptor	0	2	7	9
Mitogen-activated protein kinase kinase kinase 10	0	0	6	6
DNA topoisomerase 2-beta	0	0	13	13
Protein kinase C theta type	0	1	15	16
Activin receptor type-1	0	0	13	13
Macrophage-stimulating protein receptor	0	0	13	13
Focal adhesion kinase 1	0	2	13	15
Protein kinase C zeta type	0	2	12	14
Protein kinase C delta type	0	3	15	18
Tyrosine-protein kinase BTK	0	2	13	15
Tyrosine-protein kinase receptor TYRO3	0	0	6	6
Cyclin-dependent kinase 18	0	0	8	8
Activated CDC42 kinase 1	0	1	13	14
Epithelial discoidin domain-containing receptor 1	0	5	13	18
Tyrosine-protein kinase ITK/TSK	0	1	6	7
Myotonin-protein kinase	0	0	6	6
Mitogen-activated protein kinase kinase kinase kinase 2	0	0	13	13
Mitogen-activated protein kinase kinase kinase 12	0	0	6	6
Tyrosine-protein kinase Mer	0	2	9	11
Serine/threonine-protein kinase 4	0	0	13	13
5'-AMP-activated protein kinase catalytic subunit alpha-1	0	1	13	15
Serine/threonine-protein kinase PAK 1	0	1	6	7
Dual specificity mitogen-activated protein kinase kinase 5	0	0	13	13
Mitogen-activated protein kinase 7	0	0	13	13
Serine/threonine-protein kinase PAK 2	0	0	13	13
Serine/threonine-protein kinase 3	0	0	13	13
Mitogen-activated protein kinase kinase kinase 1	0	0	13	13
cGMP-dependent protein kinase 2	0	0	6	6
Integrin-linked protein kinase	0	0	13	13
Rho-associated protein kinase 1	0	0	13	13
Non-receptor tyrosine-protein kinase TNK1	0	0	13	13
Serine/threonine-protein kinase PRP4 homolog	0	0	6	6
Receptor-interacting serine/threonine-protein kinase 1	0	2	6	8
Calcium/calmodulin-dependent protein kinase type II subunit beta	0	0	6	6
Calcium/calmodulin-dependent protein kinase type II subunit gamma	0	0	13	13
Calcium/calmodulin-dependent protein kinase type II subunit delta	0	0	13	13
Dual specificity tyrosine-phosphorylation-regulated kinase 1A	0	2	13	15
Activin receptor type-2B	0	0	13	13
Bone morphogenetic protein receptor type-2	0	0	13	13
Protein-tyrosine kinase 6	0	1	13	14
cGMP-dependent protein kinase 1	0	0	13	13
Cyclin-dependent kinase 13	0	0	13	13
Calcium/calmodulin-dependent protein kinase type 1	0	0	6	6
Inhibitor of nuclear factor kappa-B kinase subunit epsilon	0	0	13	13
Protein-tyrosine kinase 2-beta	0	0	13	13
Maternal embryonic leucine zipper kinase	0	0	13	13
Chromodomain-helicase-DNA-binding protein 4	0	0	13	13
Peroxisomal acyl-coenzyme A oxidase 1	0	0	12	12
Serine/threonine-protein kinase D1	0	1	8	9
Serine/threonine-protein kinase 38	0	0	8	8
Receptor tyrosine-protein kinase erbB-4	0	1	6	7
Ribosomal protein S6 kinase alpha-2	0	0	6	6
Ephrin type-A receptor 7	0	0	11	11
Delta(24)-sterol reductase	0	0	13	13
Ribosomal protein S6 kinase alpha-1	0	2	13	15
Dual specificity testis-specific protein kinase 1	0	0	12	12
Myosin light chain kinase, smooth muscle	0	0	13	13
Mitogen-activated protein kinase 11	0	1	13	14
Serine/threonine-protein kinase STK11	0	0	13	13
Rhodopsin kinase GRK1	0	0	6	6
NT-3 growth factor receptor	0	0	6	6
Serine/threonine-protein kinase N1	0	0	13	13
Serine/threonine-protein kinase N2	0	0	13	13
Mitogen-activated protein kinase 14	0	6	15	21
Calcium/calmodulin-dependent protein kinase type IV	0	0	13	13
Mitogen-activated protein kinase kinase kinase 11	0	0	13	13
BDNF/NT-3 growth factors receptor	0	0	6	6
MAP kinase-activated protein kinase 3	0	0	6	6
Mitogen-activated protein kinase 6	0	0	6	6
Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform	0	0	6	6
Discoidin domain-containing receptor 2	0	5	13	18
AP2-associated protein kinase 1	0	2	13	15
Myosin light chain kinase 3	0	0	13	13
Uncharacterized aarF domain-containing protein kinase 5	0	0	9	9
Serine/threonine-protein kinase SBK1	0	0	6	6
Mitogen-activated protein kinase kinase kinase 19	0	0	6	6
Putative heat shock protein HSP 90-beta 2	0	0	13	13
Serine/threonine-protein kinase TNNI3K	0	1	6	7
Rab-like protein 3	0	0	10	10
Serine/threonine-protein kinase MRCK alpha	0	0	13	13
Serine/threonine-protein kinase MRCK gamma	0	0	12	12
Acyl-CoA dehydrogenase family member 10	0	0	12	12
Serine/threonine-protein kinase Nek5	0	0	6	6
Serine/threonine-protein kinase N3	0	0	12	12
Serine/threonine-protein kinase ULK3	0	0	13	13
Dual serine/threonine and tyrosine protein kinase	0	1	6	7
Mitogen-activated protein kinase kinase kinase 15	0	0	6	6
Uncharacterized protein FLJ45252	0	0	13	13
Acyl-CoA dehydrogenase family member 11	0	0	13	13
Serine/threonine-protein kinase/endoribonuclease IRE2	0	0	12	12
Serine/threonine-protein kinase MARK2	0	0	13	13
ATP-dependent RNA helicase DHX30	0	0	9	9
Serine/threonine-protein kinase TAO1	0	0	13	13
STE20-related kinase adapter protein alpha	0	0	13	13
Myosin-14	0	0	13	13
AarF domain-containing protein kinase 1	0	0	13	13
Serine/threonine-protein kinase tousled-like 2	0	0	6	6
Serine/threonine-protein kinase 32C	0	0	6	6
Serine/threonine-protein kinase pim-3	0	1	6	7
ATP-dependent RNA helicase DDX42	0	0	9	9
Serine/threonine-protein kinase VRK2	0	0	6	6
Myosin light chain kinase family member 4	0	0	6	6
Homeodomain-interacting protein kinase 1	0	1	6	7
Calcium/calmodulin-dependent protein kinase type 1D	0	0	6	6
Mitogen-activated protein kinase kinase kinase kinase 3	0	0	13	13
Cyclin-dependent kinase-like 3	0	0	6	6
MAP kinase-activated protein kinase 5	0	0	13	13
Serine/threonine-protein kinase BRSK2	0	0	6	6
Serine/threonine-protein kinase NIM1	0	0	6	6
Eukaryotic peptide chain release factor GTP-binding subunit ERF3B	0	0	8	8
Serine/threonine-protein kinase ULK2	0	0	6	6
Misshapen-like kinase 1	0	0	12	12
Serine/threonine-protein kinase DCLK2	0	0	6	6
Calcium/calmodulin-dependent protein kinase kinase 1	0	0	6	6
Casein kinase I isoform alpha-like	0	0	6	6
Homeodomain-interacting protein kinase 4	0	1	6	7
Myosin-IIIa	0	0	6	6
Ankyrin repeat and protein kinase domain-containing protein 1	0	0	6	6
Serine/threonine-protein kinase Nek11	0	0	6	6
Atypical kinase COQ8A, mitochondrial	0	0	13	13
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma	0	0	13	13
Mitogen-activated protein kinase 15	0	0	13	13
Serine/threonine-protein kinase Nek9	0	0	13	13
Serine/threonine-protein kinase BRSK1	0	0	6	6
Serine/threonine-protein kinase 35	0	0	6	6
Serine/threonine-protein kinase Nek7	0	0	9	9
Rhodopsin kinase GRK7	0	0	6	6
Serine/threonine-protein kinase 32A	0	0	6	6
Myosin-IIIb	0	0	6	6
ATP-dependent RNA helicase DDX1	0	0	13	13
Dual specificity tyrosine-phosphorylation-regulated kinase 2	0	1	6	7
Cyclin-dependent kinase-like 2	0	0	6	6
Mitogen-activated protein kinase kinase kinase kinase 1	0	0	13	13
Serine/threonine-protein kinase Sgk3	0	0	6	6
Atypical kinase COQ8B, mitochondrial	0	0	6	6
Aurora kinase B	0	2	13	15
MAP/microtubule affinity-regulating kinase 4	0	0	13	13
Calcium/calmodulin-dependent protein kinase type 1G	0	0	7	7
Serine/threonine-protein kinase Nek1	0	0	13	13
Cyclin-dependent kinase 15	0	0	6	6
PAS domain-containing serine/threonine-protein kinase	0	0	10	10
Calcium/calmodulin-dependent protein kinase kinase 2	0	0	13	13
EKC/KEOPS complex subunit TP53RK	0	0	13	13
SRSF protein kinase 1	0	0	6	6
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	0	2	13	15
Mitogen-activated protein kinase kinase kinase 5	0	0	13	13
Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha	0	0	6	6
Mitogen-activated protein kinase kinase kinase 3	0	0	13	13
Eukaryotic translation initiation factor 2-alpha kinase 1	0	0	13	13
Serine/threonine-protein kinase RIO1	0	0	6	6
MAP kinase-interacting serine/threonine-protein kinase 1	0	0	6	6
Serine/threonine-protein kinase RIO2	0	0	6	6
Cyclin-dependent kinase 19	0	1	6	7
Transient receptor potential cation channel subfamily M member 6	0	0	6	6
Testis-specific serine/threonine-protein kinase 1	0	0	6	6
Serine/threonine-protein kinase 33	0	0	6	6
Nucleolar GTP-binding protein 1	0	0	13	13
Serine/threonine-protein kinase D2	0	0	13	13
Serine/threonine-protein kinase DCLK3	0	0	6	6
NUAK family SNF1-like kinase 2	0	0	11	11
RNA cytidine acetyltransferase	0	0	13	13
Serine/threonine-protein kinase SIK2	0	1	13	14
Myosin light chain kinase 2, skeletal/cardiac muscle	0	0	6	6
STE20-like serine/threonine-protein kinase	0	0	13	13
Serine/threonine-protein kinase TAO3	0	0	13	13
Homeodomain-interacting protein kinase 2	0	1	6	7
Tyrosine-protein kinase Srms	0	0	6	6
Homeodomain-interacting protein kinase 3	0	1	6	7
Serine/threonine-protein kinase PLK3	0	2	6	8
dCTP pyrophosphatase 1	0	0	13	13
Dual specificity protein kinase CLK4	0	0	13	13
MAP kinase-interacting serine/threonine-protein kinase 2	0	1	6	7
Serine/threonine-protein kinase Nek6	0	0	6	6
Casein kinase I isoform gamma-1	0	0	13	13
Serine/threonine-protein kinase PAK 6	0	1	10	11
SNF-related serine/threonine-protein kinase	0	0	6	6
Serine/threonine-protein kinase LATS2	0	0	6	6
Serine/threonine-protein kinase 36	0	0	6	6
Phenylalanine--tRNA ligase beta subunit	0	0	13	13
BMP-2-inducible protein kinase	0	0	13	13
Obg-like ATPase 1	0	0	11	11
Midasin	0	0	13	13
Interleukin-1 receptor-associated kinase 4	0	0	13	13
Serine/threonine-protein kinase 32B	0	0	6	6
Mitogen-activated protein kinase kinase kinase 20	0	1	13	14
Cyclin-dependent kinase 12	0	0	13	13
Serine/threonine-protein kinase PLK2	0	2	6	8
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13	0	0	12	12
Serine/threonine-protein kinase MARK1	0	0	6	6
Serine/threonine-protein kinase pim-2	0	0	10	10
Serine/threonine-protein kinase PAK 5	0	1	6	7
Serine/threonine-protein kinase 26	0	0	13	13
eIF-2-alpha kinase GCN2	0	0	6	6
Serine/threonine-protein kinase NLK	0	0	13	13
Phosphatidylinositol 4-kinase beta	0	0	6	6
Serine/threonine-protein kinase 17A	0	0	6	6
STE20/SPS1-related proline-alanine-rich protein kinase	0	0	6	6
Ephrin type-A receptor 6	0	0	6	6
5'-AMP-activated protein kinase subunit gamma-2	0	0	13	14
Serine/threonine-protein kinase TBK1	0	1	13	14
Septin-9	0	0	13	13
Death-associated protein kinase 2	0	0	6	6
Ribosomal protein S6 kinase alpha-6	0	0	13	13
TRAF2 and NCK-interacting protein kinase	0	0	13	13
Serine/threonine-protein kinase tousled-like 1	0	0	6	6
Serine/threonine-protein kinase TAO2	0	0	13	13
Long-chain-fatty-acid--CoA ligase 5	0	0	8	8
ALK tyrosine kinase receptor	0	1	6	7
SRSF protein kinase 3	0	0	6	6
Serine/threonine-protein kinase ICK	0	0	13	13
Cyclin-dependent kinase 11A	0	0	6	6
Aurora kinase C	0	0	6	6
Calcium/calmodulin-dependent protein kinase type II subunit alpha	0	0	6	6
RAC-gamma serine/threonine-protein kinase	0	1	13	14
Serine/threonine-protein kinase 38-like	0	0	10	10
Microtubule-associated serine/threonine-protein kinase 1	0	0	6	6
Serine/threonine-protein kinase SIK3	0	1	13	14
Mitogen-activated protein kinase kinase kinase 2	0	0	13	13
Thyroid hormone receptor-associated protein 3	0	0	13	13
Dual specificity tyrosine-phosphorylation-regulated kinase 1B	0	2	11	13
Mitogen-activated protein kinase kinase kinase kinase 5	0	0	13	13
Receptor-interacting serine/threonine-protein kinase 3	0	2	13	15
Serine/threonine-protein kinase MRCK beta	0	0	13	13
Interleukin-1 receptor-associated kinase 3	0	0	13	13
Serine/threonine-protein kinase 24	0	0	12	12
Casein kinase I isoform gamma-3	0	0	13	13
Mitogen-activated protein kinase kinase kinase 4	0	0	13	13
Chain A, Vitamin D Nuclear Receptor	0	0	1	1
Vitamin D3 receptor	0	0	1	1
Vitamin D-binding protein	0	0	1	1
Cytochrome P450 3A4	0	20	1	24
Androgen receptor	0	2	0	3
Cytochrome P450 2D6	0	9	1	10
Vitamin D3 receptor	0	3	4	10
Cytochrome P450 2C9	0	17	1	21
Vitamin D3 receptor	0	1	1	3
Retinoic acid receptor RXR-alpha	0	3	3	6
Kappa-type opioid receptor	0	1	1	2
Vitamin D3 receptor	0	0	2	2
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial	0	0	1	1
Vitamin D3 receptor	0	1	1	2
Transporter	0	1	0	1
Vitamin D3 receptor A	0	0	2	2
Chain A, Putative fructose-1,6-bisphosphate aldolase	6	0	0	6
Chain A, serum paraoxonase	0	1	0	1
Carbonic anhydrase 3	0	5	0	7
Neutrophil cytosol factor 1	0	1	0	1
Carbonic anhydrase 6	0	6	0	9
Carbonic anhydrase 5A, mitochondrial	0	6	0	9
Carbonic anhydrase 9	0	9	0	13
Carbonic anhydrase 13	0	2	0	3
Poly [ADP-ribose] polymerase tankyrase-2	0	1	2	3
Carbonic anhydrase 14	0	5	0	8
Carbonic anhydrase 5B, mitochondrial	0	5	0	7
DNA polymerase beta	6	0	0	6
neuropeptide S receptor isoform A	6	0	0	6
Arginase	0	2	0	2
Prothrombin	0	1	1	2
Sucrase-isomaltase, intestinal	0	1	0	1
Mu-type opioid receptor	0	3	1	5
Delta-type opioid receptor	0	3	1	5
Kappa-type opioid receptor	0	3	1	5
Melatonin receptor type 1A	0	0	1	1
Melatonin receptor type 1B	0	0	1	1
Beta-secretase 1	0	4	0	4
Carbonic anhydrase 3	0	1	0	1
Dihydroorotate dehydrogenase	0	1	0	1
Chain A, Carbonic anhydrase II	0	1	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase	0	1	0	1
glp-1 receptor, partial	12	0	0	12
caspase 7, apoptosis-related cysteine protease	8	0	0	8
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
67.9K protein	20	0	0	20
Carbonic anhydrase	0	1	0	1
caspase-3	8	0	0	8
thyrotropin-releasing hormone receptor	6	0	0	6
interferon gamma precursor	0	0	0	1
prostaglandin E2 receptor EP2 subtype	0	0	0	1
Prostaglandin E synthase	0	3	0	3
Histone deacetylase 3	0	4	0	4
cGMP-specific 3',5'-cyclic phosphodiesterase	0	1	0	1
Cytochrome c oxidase subunit 1	0	1	0	1
Cytochrome c oxidase subunit 2	0	1	0	1
Catechol O-methyltransferase	0	1	0	1
Cytochrome c oxidase subunit 2	0	2	0	2
Procathepsin L	0	2	2	4
Neuronal acetylcholine receptor subunit alpha-4	1	1	0	2
Polyunsaturated fatty acid 5-lipoxygenase	0	4	0	4
Quinolone resistance protein NorA	0	2	0	2
Adenosine receptor A3	0	9	1	10
Neuronal acetylcholine receptor subunit beta-2	1	1	0	2
Beta-3 adrenergic receptor	0	4	1	5
Alpha-1B adrenergic receptor	0	10	2	12
Calpain-2 catalytic subunit	0	1	0	1
5-hydroxytryptamine receptor 1A	0	4	1	6
D(1A) dopamine receptor	0	6	1	7
Prostaglandin G/H synthase 1	0	1	0	1
Sodium-dependent noradrenaline transporter	0	7	1	8
Cruzipain	0	2	0	2
Sodium/hydrogen exchanger 1	0	1	0	1
Indoleamine 2,3-dioxygenase 1	0	2	0	2
Sodium-dependent serotonin transporter	0	5	0	5
Sodium-dependent serotonin transporter	0	3	1	4
Delta-type opioid receptor	0	1	1	2
Delta-type opioid receptor	0	2	0	2
Mu-type opioid receptor	0	3	0	3
Prostaglandin G/H synthase 2	0	3	0	3
Carbonic anhydrase	0	1	0	2
Alpha-1A adrenergic receptor	0	10	2	12
Carbonic anhydrase	0	1	0	2
Histone deacetylase 4	0	4	0	4
D(2) dopamine receptor	0	1	0	1
Carbonic anhydrase	0	1	0	1
Mu-type opioid receptor	0	3	0	3
Beta-carbonic anhydrase 1	0	1	0	1
Carbonic anhydrase 2	0	1	0	1
Sodium-dependent dopamine transporter	0	8	0	8
Prostaglandin G/H synthase 2	0	3	0	3
Histone deacetylase 1	0	5	0	5
Carbonic anhydrase, alpha family	0	1	0	1
Carbonic anhydrase	0	1	0	2
Carbonic anhydrase	0	1	0	2
Carbonic anhydrase	0	1	0	2
Carbonic anhydrase	0	1	0	1
Sigma intracellular receptor 2	0	1	0	1
Delta carbonic anhydrase	0	1	0	1
Prostaglandin G/H synthase 1	0	3	0	3
Carbonic anhydrase	0	1	0	2
Prostaglandin G/H synthase 1	0	1	0	1
Cyclooxygenase-2	0	1	0	1
Histone deacetylase 7	0	4	0	4
Histone deacetylase 2	0	5	0	5
Carbonic anhydrase 4	0	3	0	4
Polyamine deacetylase HDAC10	0	4	0	4
Histone deacetylase 11	0	4	0	4
Carbonic anhydrase 15	0	4	0	5
Histone deacetylase 8	0	5	0	5
P2Y purinoceptor 12	0	2	0	2
Histone deacetylase 6	0	6	0	6
Histone deacetylase 9	0	4	0	4
Histone deacetylase 5	0	4	0	4
atrial natriuretic peptide receptor 2 precursor	3	0	0	3
Histamine H1 receptor	0	1	0	1
Potassium voltage-gated channel subfamily H member 2	0	11	0	11
Multidrug and toxin extrusion protein 1	0	6	0	6
Histamine H4 receptor	0	1	0	1
glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase	0	1	0	1
Spike glycoprotein	0	1	2	3
Replicase polyprotein 1ab	0	1	2	3
glucose-6-phosphate 1-dehydrogenase isoform b	0	1	0	1
Transmembrane protease serine 2	0	1	2	3
Dihydrofolate reductase	0	2	0	2
DNA ligase	0	1	0	1
Riboflavin-binding protein	0	1	2	3
Major prion protein	0	0	2	2
Amyloid-beta precursor protein	1	6	0	8
Histidine-rich protein PFHRP-II	0	2	0	3
Muscarinic acetylcholine receptor M2	0	9	2	12
Muscarinic acetylcholine receptor M4	0	8	0	8
Muscarinic acetylcholine receptor M5	0	8	0	8
Alpha-2A adrenergic receptor	0	7	2	10
Replicase polyprotein 1a	0	1	2	3
Replicase polyprotein 1ab	0	1	2	3
Replicase polyprotein 1ab	0	4	3	7
Spike glycoprotein	0	2	0	2
Replicase polyprotein 1ab	0	7	3	10
Muscarinic acetylcholine receptor M1	0	9	1	11
Alpha-2C adrenergic receptor	0	7	2	10
DNA ligase 1	0	1	0	1
Muscarinic acetylcholine receptor M3	0	9	1	10
Nuclear receptor subfamily 4 group A member 2	0	0	2	2
Calcium-dependent protein kinase 1	0	0	1	1
MO15-related protein kinase Pfmrk	0	2	0	2
DNA ligase A	0	1	0	1
Sigma intracellular receptor 2	0	1	0	1
Phosphoethanolamine N-methyltransferase	0	1	0	1
Angiotensin-converting enzyme 2	0	1	2	3
Cysteine proteinase falcipain 2a	0	1	0	1
Cysteine proteinase falcipain 2a	0	1	0	1
60 kDa chaperonin	0	7	0	7
60 kDa heat shock protein, mitochondrial	0	8	0	8
Glycine receptor subunit alpha-1	0	0	2	2
10 kDa heat shock protein, mitochondrial	0	8	0	8
Thiosulfate sulfurtransferase	0	7	0	7
60 kDa chaperonin	0	8	0	8
10 kDa chaperonin	0	8	0	8
mu opioid receptor, partial	0	0	1	1
90-kda heat shock protein beta HSP90 beta, partial	0	1	0	1
LAP4	0	0	1	1
MEP2	0	0	1	1
delta-type opioid receptor	0	1	1	2
kappa-type opioid receptor isoform 1	0	1	0	1
ubiquitin carboxyl-terminal hydrolase 2 isoform a	6	0	0	6
heat shock protein HSP 90-alpha isoform 2	0	1	0	3
DNA dC->dU-editing enzyme APOBEC-3F isoform a	3	0	0	3
Botulinum neurotoxin type A	0	2	0	2
Catechol O-methyltransferase	0	1	0	1
Alpha-1D adrenergic receptor	0	3	2	5
Alpha-synuclein	6	4	1	11
Disintegrin and metalloproteinase domain-containing protein 17	4	0	0	4
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
Beta-galactosidase	0	0	1	1
Carbonic anhydrase 13	0	3	0	6
HSP40, subfamily A [Plasmodium falciparum 3D7]	0	0	0	2
heat shock protein 90, putative	0	0	0	2
PAX8	0	0	0	3
cytochrome P450 2D6 isoform 1	6	0	0	6
nuclear receptor subfamily 0 group B member 1	0	2	0	2
steroidogenic factor 1	0	2	0	2
Solute carrier family 22 member 3	0	2	0	2
Tubulin alpha-1A chain	0	4	3	8
Tubulin beta chain	0	4	3	7
Plasma kallikrein	0	0	0	2
Tubulin beta-4A chain	0	4	5	12
ATP-dependent translocase ABCB1	0	4	0	4
Tubulin beta chain	0	4	5	12
ATP-dependent translocase ABCB1	0	9	3	16
Tubulin alpha-3C chain	0	4	5	12
ATP-dependent translocase ABCB1	0	5	0	5
Tubulin alpha-1B chain	0	4	5	12
Tubulin alpha-4A chain	0	4	5	12
Tubulin beta-4B chain	0	4	5	12
Vesicular acetylcholine transporter	0	1	0	1
Tubulin beta-3 chain	0	5	5	13
Tubulin beta-2A chain	0	4	5	12
Tubulin polymerization-promoting protein	0	0	1	1
Tubulin beta-8 chain	0	4	5	12
Tubulin beta-2B chain	0	3	1	6
Tubulin alpha-3E chain	0	4	5	12
Tubulin alpha-1A chain	0	4	5	12
Similar to alpha-tubulin isoform 1	0	2	1	5
Similar to alpha-tubulin isoform 1	0	2	0	4
CREB-binding protein	1	1	0	2
Tubulin alpha-1C chain	0	4	5	12
Tubulin beta-6 chain	0	4	5	12
Tubulin beta-2B chain	0	4	5	12
Tubulin beta-1 chain	0	4	5	12
dopamine D1 receptor	3	0	0	3
atrial natriuretic peptide receptor 1 precursor	1	0	0	1
Sex hormone-binding globulin	0	0	2	2
Corticosteroid-binding globulin	0	2	0	2
Potassium voltage-gated channel subfamily A member 1	0	0	1	1
Chain A, Breast cancer type 1 susceptibility protein	1	0	0	1
Nrf2	1	0	0	1
alkaline phosphatase, intestinal	0	1	0	1
PINK1	3	0	0	3
Parkin	7	0	0	7
toll-like receptor 9	0	1	0	1
TPA: protein transporter TIM10	0	1	0	1
lysosomal alpha-glucosidase preproprotein	2	0	0	2
alkaline phosphatase, tissue-nonspecific isozyme isoform 1 preproprotein	0	1	0	1
perilipin-5	0	1	0	1
intestinal alkaline phosphatase precursor	0	1	0	1
perilipin-1	0	1	0	1
transcriptional regulator ERG isoform 3	3	0	0	3
pyruvate kinase PKM isoform a	1	0	0	1
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a	0	1	0	1
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	3	0	0	3
alkaline phosphatase, germ cell type preproprotein	0	1	0	1
hypothetical protein SA1422	0	1	0	1
Acetylcholinesterase	0	2	0	2
Lysine-specific histone demethylase 1A	0	1	0	1
D-amino-acid oxidase	0	1	0	1
Phospholipase A2	0	1	0	1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	0	3	0	3
Neuronal proto-oncogene tyrosine-protein kinase Src	0	1	0	2
Heme oxygenase 1	0	1	0	1
Glutathione S-transferase P	0	2	0	2
Microtubule-associated protein tau	0	1	0	2
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2	0	1	0	1
Tissue factor	0	2	0	2
Aminopeptidase N	0	1	0	1
Aminopeptidase N	0	1	0	1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2	0	2	0	2
Glycogen synthase kinase-3 beta	0	1	0	1
Amine oxidase [flavin-containing] A	0	7	0	7
Voltage-dependent L-type calcium channel subunit alpha-1C	0	2	0	2
Heme oxygenase 2	0	1	0	1
Amine oxidase [flavin-containing] B	0	4	0	4
Voltage-dependent L-type calcium channel subunit alpha-1D	0	1	0	1
Proteasome subunit beta type-5	0	2	0	2
17-beta-hydroxysteroid dehydrogenase type 2	0	2	0	2
Guanine nucleotide-binding protein G	5	0	0	5
Cholinesterase	0	3	0	3
Voltage-dependent L-type calcium channel subunit alpha-1S	0	1	0	1
Lactoylglutathione lyase	0	2	0	2
Histone acetyltransferase p300	0	1	0	1
5-hydroxytryptamine receptor 4	0	0	1	1
Nuclear factor erythroid 2-related factor 2	0	0	1	1
Thioredoxin reductase 1, cytoplasmic	0	1	0	1
Thioredoxin reductase 3	0	1	0	1
Sortase A	0	1	0	1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 3	0	2	0	2
Cysteine protease	0	1	0	1
NACHT, LRR and PYD domains-containing protein 3	0	1	0	1
Thioredoxin reductase 2, mitochondrial	0	1	0	1
CDGSH iron-sulfur domain-containing protein 1	0	4	0	4
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	13	0	14
Lymphocyte antigen 96	0	0	1	1
Beta lactamase (plasmid)	0	1	0	1
Alpha-tocopherol transfer protein	0	0	1	1
Pirin	0	2	0	2
Eukaryotic translation initiation factor 5B	0	0	10	10
Nuclear receptor subfamily 1 group I member 2	0	0	3	3
GTPase KRas	0	2	0	2
UMP-CMP kinase	0	0	9	9
Heat shock factor protein 1	0	2	0	2
ATP-dependent 6-phosphofructokinase, platelet type	0	0	12	12
Structural maintenance of chromosomes protein 1A	0	0	12	12
Cyclin-dependent kinase 10	0	0	4	4
Dual specificity testis-specific protein kinase 2	0	0	9	9
Isoleucine--tRNA ligase, mitochondrial	0	0	10	10
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	0	1	0	1
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha	0	1	0	1
Phosphatidylinositol 3-kinase regulatory subunit alpha	0	1	1	2
Serine-protein kinase ATM	0	1	0	1
Serine/threonine-protein kinase ATR	0	0	5	5
Regulatory-associated protein of mTOR	0	2	0	2
Phosphatidylinositol 3-kinase catalytic subunit type 3	0	1	0	1
Phosphoinositide 3-kinase regulatory subunit 5	0	1	0	1
Target of rapamycin complex subunit LST8	0	2	0	2
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial	0	0	11	11
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0	1	0	1
GALC protein	5	0	0	5
tyrosine-protein kinase Yes	7	0	0	7
Voltage-dependent L-type calcium channel subunit alpha-1F	0	4	0	4
Tyrosine-protein kinase ABL1	0	3	0	3
Proto-oncogene tyrosine-protein kinase Src	0	2	2	4
Transthyretin	0	2	3	7
Proto-oncogene tyrosine-protein kinase LCK	0	2	0	2
Cytochrome P450 2A6	0	2	1	3
Myosin light chain kinase, smooth muscle	0	0	3	3
Angiotensin-converting enzyme	0	1	0	1
Potassium voltage-gated channel subfamily E member 1	0	3	0	3
Tyrosine-protein kinase Blk	0	1	0	1
Cytochrome P450 2B6	0	2	0	2
G protein-coupled receptor kinase 6	0	0	8	8
Potassium voltage-gated channel subfamily KQT member 1	0	3	0	3
Tubulin alpha-1A chain	0	0	3	3
DNA-dependent protein kinase catalytic subunit	0	3	0	3
Myelin transcription factor 1	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	4	0	4
Voltage-dependent L-type calcium channel subunit alpha-1S	0	4	0	4
Voltage-dependent L-type calcium channel subunit alpha-1C	0	5	0	5
Sodium channel protein type 5 subunit alpha	0	6	0	6
Breakpoint cluster region protein	0	2	0	2
Protein cereblon	0	2	1	4
Potassium voltage-gated channel subfamily D member 3	0	3	0	3
NF-kappa-B essential modulator	0	1	0	1
Chain A, STEROID DELTA-ISOMERASE	0	0	1	1
Steroid Delta-isomerase	0	0	1	1
Ileal sodium/bile acid cotransporter	0	1	0	1
Bile acid receptor	0	0	1	1
Thymidine kinase 2	0	1	0	1
Probable deoxycytidylate deaminase	0	0	0	1
Cytidine deaminase	0	0	0	1
AAA family ATPase	0	0	0	1
Reverse transcriptase/RNaseH	0	0	1	1
Aldo-keto reductase family 1 member B10	0	2	0	2
UDP-glucuronosyltransferase 1A9	0	1	0	2
Transient receptor potential cation channel subfamily A member 1	0	0	1	1
Dihydrofolate reductase	0	5	0	6
Albumin	0	4	5	9
Interleukin-8	0	1	0	1
Calcium/calmodulin-dependent protein kinase type II subunit alpha	0	1	0	1
Fatty acid-binding protein, intestinal	0	1	0	1
UDP-glucuronosyltransferase 2B7	0	2	0	4
UDP-glucuronosyltransferase 1-6	0	3	0	3
UDP-glucuronosyltransferase 1A1	0	3	0	3
UDP-glucuronosyltransferase 1A4	0	2	0	3
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
C-X-C chemokine receptor type 1	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
UDP-glucuronosyltransferase 1A3	0	0	0	1
UDP-glucuronosyltransferase 2B10	0	2	0	2
Sodium- and chloride-dependent betaine transporter	0	1	0	1
Cytochrome P450 2J2	0	6	0	6
Solute carrier family 22 member 6	0	4	0	5
UDP-glucuronosyltransferase 1A7	0	1	0	1
UDP-glucuronosyltransferase 1A10	0	1	0	1
NAD	0	1	0	1
NAD	0	1	0	2
ATP phosphoribosyltransferase	0	1	0	1
Proprotein convertase subtilisin/kexin type 7	0	1	0	1
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	2	0	2
Integrase	0	3	0	3
G-protein coupled receptor 35	0	2	2	4
STAT3, partial	0	1	0	1
NPC intracellular cholesterol transporter 1 precursor	5	0	0	5
tumor necrosis factor	2	0	0	2
signal transducer and activator of transcription 1-alpha/beta isoform alpha	0	1	0	1
Solute carrier organic anion transporter family member 1A4	0	1	0	2
Sodium/potassium-transporting ATPase subunit alpha-1	0	2	0	2
Sodium/potassium-transporting ATPase subunit beta-1	0	2	0	2
Sodium/potassium-transporting ATPase subunit alpha-2	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-3	0	1	0	1
Sodium/potassium-transporting ATPase subunit beta-1	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-3	0	1	0	1
Sodium/potassium-transporting ATPase subunit beta-2	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-2	0	2	0	2
Sodium/potassium-transporting ATPase subunit alpha-1	0	1	0	1
Sodium/potassium-transporting ATPase subunit beta-3	0	1	0	1
Sodium/potassium-transporting ATPase subunit gamma	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-4	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-4	0	1	0	1
Solute carrier organic anion transporter family member 4C1	0	0	0	1
Solute carrier organic anion transporter family member 4C1	0	0	0	1
Solute carrier organic anion transporter family member 1A4	0	0	0	1
Solute carrier organic anion transporter family member 1B3	0	7	0	8
Solute carrier organic anion transporter family member 1B1	0	10	0	10
Cereblon isoform 4	0	2	0	2
Insulin-like growth factor-binding protein 5	0	0	1	1
Choline O-acetyltransferase	0	1	0	1
Serum paraoxonase/arylesterase 1	0	3	0	3
Kinesin-like protein KIF11	0	1	0	1
Nucleotide-binding oligomerization domain-containing protein 2	0	2	0	2
Mitochondrial 2-oxodicarboxylate carrier	0	1	0	1
Motilin receptor	0	0	1	1
low molecular weight phosphotyrosine protein phosphatase isoform c	0	1	0	1
streptokinase A precursor	0	0	2	2
Motilin receptor	0	1	1	2
30S ribosomal protein S6	0	1	1	2
30S ribosomal protein S7	0	1	1	2
50S ribosomal protein L15	0	1	1	2
50S ribosomal protein L10	0	1	1	2
50S ribosomal protein L11	0	1	1	2
50S ribosomal protein L7/L12	0	1	1	2
50S ribosomal protein L19	0	1	1	2
50S ribosomal protein L1	0	1	1	2
50S ribosomal protein L20	0	1	1	2
50S ribosomal protein L27	0	1	1	2
50S ribosomal protein L28	0	1	1	2
50S ribosomal protein L29	0	1	1	2
50S ribosomal protein L31	0	1	1	2
50S ribosomal protein L31 type B	0	1	1	2
50S ribosomal protein L32	0	1	1	2
50S ribosomal protein L33	0	1	1	2
50S ribosomal protein L34	0	1	1	2
50S ribosomal protein L35	0	1	1	2
50S ribosomal protein L36	0	1	1	2
30S ribosomal protein S10	0	1	1	2
30S ribosomal protein S11	0	1	1	2
30S ribosomal protein S12	0	1	1	2
30S ribosomal protein S13	0	1	1	2
30S ribosomal protein S16	0	1	1	2
30S ribosomal protein S18	0	1	1	2
30S ribosomal protein S19	0	1	1	2
30S ribosomal protein S20	0	1	1	2
30S ribosomal protein S2	0	1	1	2
30S ribosomal protein S3	0	1	1	2
30S ribosomal protein S4	0	1	1	2
30S ribosomal protein S5	0	1	1	2
30S ribosomal protein S8	0	1	1	2
30S ribosomal protein S9	0	1	1	2
50S ribosomal protein L13	0	1	1	2
50S ribosomal protein L14	0	1	1	2
50S ribosomal protein L16	0	1	1	2
50S ribosomal protein L23	0	1	1	2
30S ribosomal protein S15	0	1	1	2
50S ribosomal protein L17	0	1	1	2
50S ribosomal protein L21	0	1	1	2
50S ribosomal protein L30	0	1	1	2
50S ribosomal protein L6	0	1	1	2
30S ribosomal protein S14	0	1	1	2
30S ribosomal protein S17	0	1	1	2
30S ribosomal protein S1	0	1	1	2
50S ribosomal protein L18	0	1	1	2
Chitinase B	0	1	0	1
Low molecular weight phosphotyrosine protein phosphatase	0	1	0	1
50S ribosomal protein L2	0	1	1	2
50S ribosomal protein L3	0	1	1	2
50S ribosomal protein L24	0	1	1	2
50S ribosomal protein L4	0	1	1	2
50S ribosomal protein L22	0	1	1	2
50S ribosomal protein L5	0	1	1	2
30S ribosomal protein S21	0	1	1	2
50S ribosomal protein L25	0	1	1	2
Cytochrome P450 1B1	0	2	0	2
Lanosterol 14-alpha demethylase	0	1	0	1
50S ribosomal protein L36 2	0	1	1	2
Chain A, Uracil Phosphoribosyltransferase	0	1	0	1
Skn7p	0	0	0	1
Vpr	3	0	0	3
Solute carrier family 22 member 8	0	0	0	1
Thymidylate synthase	0	4	0	5
Aromatase	0	4	0	4
Glucose-6-phosphate 1-dehydrogenase	0	3	0	3
Corticosteroid 11-beta-dehydrogenase isozyme 1	0	1	0	1
Adenosine receptor A1	0	1	0	1
Corticosteroid 11-beta-dehydrogenase isozyme 1	0	1	0	1
6-phosphogluconate dehydrogenase, decarboxylating	0	2	0	2
Holo-[acyl-carrier-protein] synthase	0	1	0	1
Solute carrier organic anion transporter family member 2A1	0	1	0	1
Chain A, Type Iii Chloramphenicol Acetyltransferase	0	1	0	1
Estrogen receptor	0	0	1	1
Estrogen receptor beta	0	0	1	1
Canalicular multispecific organic anion transporter 1	0	2	0	3
Albumin	0	0	1	1
Smoothened homolog	0	1	1	2
Sonic hedgehog protein	0	1	0	2
Sonic hedgehog protein	0	2	0	2
Smoothened homolog	0	3	2	5
Ras-related C3 botulinum toxin substrate 1	0	0	2	2
Chain A, Estrogen receptor 1 (alpha)	0	1	0	1
Chain A, Transthyretin	0	0	1	1
Chain A, Transthyretin	0	0	1	1
BRCA1	1	0	0	1
Alpha-mannosidase	0	1	0	1
pyruvate kinase	2	0	0	2
hexokinase-4 isoform 1	1	0	0	1
histone deacetylase 9 isoform 3	3	0	0	3
glucokinase regulatory protein	1	0	0	1
glycogen synthase kinase-3 beta isoform 1	0	0	1	1
Maltase-glucoamylase, intestinal	0	2	0	2
5-hydroxytryptamine receptor 4	0	6	0	6
Steroid hormone receptor ERR2	0	1	0	1
Triosephosphate isomerase	0	1	0	1
Estrogen receptor	0	2	1	3
Solute carrier family 2, facilitated glucose transporter member 1	0	1	0	1
Tyrosinase	0	1	0	1
Steroid hormone receptor ERR1	0	1	0	1
Ornithine decarboxylase	0	1	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15	0	1	0	1
Cystic fibrosis transmembrane conductance regulator	0	0	2	2
17-beta-hydroxysteroid dehydrogenase type 1	0	1	0	1
Solute carrier family 2, facilitated glucose transporter member 4	0	2	0	2
G2/mitotic-specific cyclin-B1	0	2	0	2
Dipeptidyl peptidase 4	0	1	0	1
Androgen receptor	0	3	0	3
Amine oxidase [flavin-containing] A	0	1	0	1
Amine oxidase [flavin-containing] A	0	1	0	1
G1/S-specific cyclin-D1	0	2	0	2
Thromboxane-A synthase	0	1	0	1
DNA (cytosine-5)-methyltransferase 1	0	1	0	1
Dipeptidyl peptidase 4	0	1	0	1
5-hydroxytryptamine receptor 2A	0	11	1	12
5-hydroxytryptamine receptor 2C	0	8	1	9
Adenosine receptor A2a	0	7	1	8
Adenosine receptor A1	0	2	0	2
Cystic fibrosis transmembrane conductance regulator	0	0	1	1
Testosterone 17-beta-dehydrogenase 3	0	1	0	1
Acetylcholinesterase	0	1	0	1
Alpha-glucosidase MAL32	0	1	0	1
Signal transducer and activator of transcription 3	0	1	0	1
Quinone oxidoreductase	0	0	0	1
Oxysterols receptor LXR-beta	0	2	0	2
Amine oxidase [flavin-containing] B	0	1	0	1
Xanthine dehydrogenase/oxidase	0	2	0	2
Aldehyde oxidase	0	4	0	4
Oxysterols receptor LXR-alpha	0	1	0	1
Tissue alpha-L-fucosidase	0	1	0	1
Substance-K receptor	0	1	0	1
Estrogen receptor beta	0	2	1	3
Beta-hydroxyacyl-ACP dehydratase precursor (Fatty acid synthesis protein)	0	1	0	1
Prenyltransferase homolog	0	0	0	1
Carboxylic ester hydrolase	0	1	0	1
Dipeptidyl peptidase 3	0	1	0	1
DNA (cytosine-5)-methyltransferase 3-like	0	1	0	1
Sialidase-2	0	1	0	1
DNA (cytosine-5)-methyltransferase 3A	0	1	0	1
beta-amyloid peptide, A beta {N-terminal} [human, cerebrospinal fluid, conditioned medium of mixed-brain cell cultures, Peptide Partial, 33 aa]	1	0	0	1
alpha synuclein, partial	1	0	0	1
luciferase	2	0	0	2
Solute carrier family 22 member 1	0	2	0	3
D(2) dopamine receptor	0	4	1	5
Substance-K receptor	0	4	0	4
Glutamate receptor ionotropic, kainate 1	1	0	0	1
Histamine H2 receptor	0	6	0	6
Alpha-1D adrenergic receptor	0	7	1	9
D(3) dopamine receptor	0	8	0	8
Glutamate receptor ionotropic, kainate 2	1	0	0	1
Fatty-acid amide hydrolase 1	1	2	0	3
Glutamate receptor ionotropic, kainate 4	1	0	0	1
Leukotriene B4 receptor 1	1	0	0	1
Glutamate receptor ionotropic, kainate 5	1	0	0	1
Leukotriene B4 receptor 2	1	0	0	1
Chain A, Glutamine Binding Protein	0	0	1	1
Neutral amino acid transporter A	0	1	0	1
Asc-type amino acid transporter 1	0	1	0	1
Neutral amino acid transporter B(0)	0	1	0	1
Carbonic anhydrase-like protein, putative	0	0	0	2
Amino acid transporter	0	1	0	1
Glutathione reductase	0	0	0	1
Multidrug resistance-associated protein 1	0	0	0	2
Histone-lysine N-methyltransferase EHMT2	0	1	0	1
Histone-lysine N-methyltransferase EHMT1	0	1	0	1
Chain A, Dual specificity tyrosine-phosphorylation-regulated kinase 1A	0	1	0	1
5-hydroxytryptamine receptor 3E	0	1	0	1
Glycogen synthase kinase-3 beta	0	1	0	1
CDC-like kinase 1, isoform CRA_c	0	0	0	1
[Tau protein] kinase	0	1	0	1
dual specificity protein kinase CLK4	1	0	0	1
Dual specificity protein kinase CLK2	0	1	0	1
Dual specificity protein kinase CLK3	0	1	0	1
Dual specificity protein kinase CLK4	0	1	0	1
Dual specificity tyrosine-phosphorylation-regulated kinase 3	0	1	0	1
Cyclin-T1	0	1	0	1
G2/mitotic-specific cyclin-B2	0	1	0	1
5-hydroxytryptamine receptor 3B	0	1	0	1
Protein kinase C gamma type	0	2	2	4
Beta-2 adrenergic receptor	0	3	1	4
Beta-1 adrenergic receptor	0	3	1	4
5-hydroxytryptamine receptor 1A	0	3	0	3
5-hydroxytryptamine receptor 2A	0	3	0	3
Cyclin-A2	0	1	0	1
D(4) dopamine receptor	0	1	0	1
D(1B) dopamine receptor	0	1	0	1
Dual specificity protein kinase CLK1	0	1	0	1
Metabotropic glutamate receptor 1	0	1	0	1
Sodium-dependent dopamine transporter	0	1	0	1
5-hydroxytryptamine receptor 1D	0	1	0	2
5-hydroxytryptamine receptor 1B	0	3	1	4
Neuromedin-B receptor	0	1	0	1
Alpha-2B adrenergic receptor	0	1	0	1
Metabotropic glutamate receptor 2	0	1	0	1
Metabotropic glutamate receptor 3	0	1	0	1
Metabotropic glutamate receptor 4	0	1	0	1
Metabotropic glutamate receptor 5	0	1	0	1
5-hydroxytryptamine receptor 7	0	3	1	4
Alpha-1A adrenergic receptor	0	2	2	5
Metabotropic glutamate receptor 6	0	1	0	1
Alpha-1B adrenergic receptor	0	1	1	3
Metabotropic glutamate receptor 7	0	1	0	1
5-hydroxytryptamine receptor 3A	0	1	0	1
5-hydroxytryptamine receptor 5A	0	2	0	2
5-hydroxytryptamine receptor 6	0	4	1	5
Cyclin-H	0	1	0	1
Mitogen-activated protein kinase 1	0	1	0	1
Metabotropic glutamate receptor 8	0	1	0	1
Cyclin-A1	0	1	0	1
Alpha-2C adrenergic receptor	0	1	0	1
Alpha-2A adrenergic receptor	0	1	0	1
Cyclin-dependent kinase 5 activator 1	0	1	0	1
Dual specificity tyrosine-phosphorylation-regulated kinase 1A	0	1	0	1
5-hydroxytryptamine receptor 3D	0	1	0	1
Serine/threonine-protein kinase haspin	0	1	0	1
G2/mitotic-specific cyclin-B3	0	1	0	1
5-hydroxytryptamine receptor 3C	0	1	0	1
Dual specificity tyrosine-phosphorylation-regulated kinase 4	0	1	0	1
Transporter	0	1	0	1
Nischarin	0	1	0	1
Chain A, HISTIDINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Histidine-binding periplasmic protein	0	0	1	1
Large neutral amino acids transporter small subunit 1	0	1	0	1
Glutaminyl-peptide cyclotransferase	0	1	0	1
Glutamate receptor ionotropic, NMDA 2D	0	0	0	1
Glutamate receptor ionotropic, NMDA 3B	0	0	0	1
Glutamate receptor ionotropic, NMDA 3A	0	0	0	1
Gamma-aminobutyric acid receptor subunit pi	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	0	1	0	1
Stromelysin-1	0	0	2	2
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	0	1
Urease subunit alpha	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	0	1
Ribonucleoside-diphosphate reductase large subunit	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	0	1
Urease subunit beta	0	2	0	2
Gamma-aminobutyric acid receptor subunit epsilon	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit theta	0	1	0	1
Thioredoxin reductase 1, cytoplasmic	0	1	0	1
Dopamine beta-hydroxylase	0	1	0	1
Corticotropin-releasing factor receptor 1	0	1	0	1
Cystathionine beta-synthase	0	1	0	1
Glutathione reductase	0	1	0	1
5-lipoxygenase	0	1	0	1
Cysteine protease ATG4B	0	1	0	1
Thioredoxin reductase 2, mitochondrial	0	1	0	1
DNA repair protein RAD52 homolog isoform a	0	0	0	1
Cytochrome P450 3A5	0	2	0	3
7,8-dihydro-8-oxoguanine triphosphatase	0	2	0	2
Toll-like receptor 8	0	0	2	4
Toll-like receptor 7	0	0	2	4
Tyrosine-protein kinase JAK2	0	0	1	1
Peptide deformylase 1A, chloroplastic/mitochondrial	0	1	0	1
Peptide deformylase	0	1	0	1
Ornithine decarboxylase	0	0	0	2
Retinoic acid receptor alpha	0	2	2	4
Retinoic acid receptor gamma	0	2	2	4
Retinoic acid receptor beta	0	2	2	4
Cellular retinoic acid-binding protein 2	0	0	2	2
Retinoic acid receptor RXR-alpha	0	2	2	4
Retinoic acid receptor RXR-beta	0	2	2	4
Retinoic acid receptor RXR-gamma	0	2	2	4
Cellular retinoic acid-binding protein 1	0	2	0	3
5-hydroxytryptamine receptor 2B	0	9	1	10
Cellular retinoic acid-binding protein 1	0	0	2	2
Olfactory receptor 51E2	0	1	1	2
Cytochrome P450 144	0	0	2	2
Steroid C26-monooxygenase	0	0	2	2
Steroid C26-monooxygenase	0	0	2	2
Cytochrome P450 1A1	0	2	0	2
Potassium channel subfamily K member 3	0	2	0	2
Potassium channel subfamily K member 2	0	1	0	1
Sodium channel protein type 1 subunit alpha	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	1	0	1
Sodium channel protein type 3 subunit alpha	0	1	0	1
Potassium voltage-gated channel subfamily A member 5	0	1	0	1
Sodium channel protein type 4 subunit alpha	0	1	0	1
Sodium channel protein type 9 subunit alpha	0	3	0	3
Potassium voltage-gated channel subfamily D member 2	0	1	0	1
Potassium channel subfamily K member 18	0	1	0	1
Sodium channel protein type 3 subunit alpha	0	2	0	2
HLA class I histocompatibility antigen, A alpha chain	0	1	1	2
5-hydroxytryptamine receptor 2C	0	2	0	3
5-hydroxytryptamine receptor 2B	0	1	0	1
Gastrin/cholecystokinin type B receptor	0	1	0	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
ClpP	2	0	0	2
Thymidylate synthase	0	2	0	2
Thymidylate synthase	0	2	0	2
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]	0	1	0	1
transactivating tegument protein VP16 [Human herpesvirus 1]	0	2	0	2
nuclear receptor coactivator 3 isoform a	0	1	0	1
Toll-like receptor 4	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
ATP-binding cassette sub-family C member 3	0	1	0	2
Dihydrofolate reductase	0	3	0	4
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	3	0	4
Thymidylate synthase	0	3	0	3
Thymidylate synthase	0	4	0	4
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
High mobility group protein B1	0	0	2	2
Dihydrofolate reductase	0	1	0	1
Thymidylate synthase	0	1	0	1
Dihydrofolate reductase	0	3	2	5
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Folate receptor beta	0	2	0	2
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Folate receptor alpha	0	2	0	2
Dihydrofolate reductase	0	3	0	3
Histidine decarboxylase	0	1	0	1
Trifunctional purine biosynthetic protein adenosine-3	0	3	0	3
Bifunctional purine biosynthesis protein ATIC	0	4	0	4
Kappa-type opioid receptor	0	1	0	1
Reduced folate transporter	0	3	0	3
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
Solute carrier organic anion transporter family member 1A3	0	0	0	1
Dihydrofolate reductase	0	1	0	1
Pteridine reductase 1	0	1	0	1
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
Bifunctional dihydrofolate reductase-thymidylate synthase	0	2	0	2
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Trifunctional purine biosynthetic protein adenosine-3	0	2	0	2
Dihydrofolate reductase	0	1	0	1
Solute carrier family 22 member 8	0	2	0	3
Dihydrofolate reductase	0	1	0	1
ATP-binding cassette sub-family C member 11	0	0	0	1
Proton-coupled folate transporter	0	3	0	4
Multidrug resistance associated protein	0	1	0	2
Solute carrier family 22 member 11	0	1	0	2
Cytochrome P450 2A13	0	1	1	2
isocitrate dehydrogenase 1, partial	2	0	0	2
Progesterone receptor	0	0	1	1
Chain A, NAD-dependent deacetylase	0	1	0	1
Poly [ADP-ribose] polymerase 2	0	1	0	1
NAD-dependent histone deacetylase SIR2	0	1	0	1
Coagulation factor VII	0	1	0	1
Poly [ADP-ribose] polymerase 1	0	1	0	1
NAD-dependent protein deacetylase HST2	0	1	0	1
NAD(+) hydrolase SARM1	0	1	0	1
NAD-dependent protein deacetylase sirtuin-2	0	2	0	2
NAD-dependent protein deacetylase sirtuin-6	0	1	0	1
NAD-dependent protein deacetylase sirtuin-1	0	1	0	1
NAD-dependent protein deacetylase sirtuin-3, mitochondrial	0	1	0	1
NAD-dependent protein deacylase sirtuin-5, mitochondrial	0	1	0	1
NAD-dependent protein deacetylase	0	1	0	1
D(1A) dopamine receptor	3	0	0	3
Muscarinic acetylcholine receptor M1	0	2	0	2
Muscarinic acetylcholine receptor M3	0	2	0	2
Muscarinic acetylcholine receptor M2	0	2	0	2
MBT domain-containing protein 1	0	1	0	1
Lethal(3)malignant brain tumor-like protein 4	0	1	0	1
Muscarinic acetylcholine receptor	0	0	1	1
Lethal(3)malignant brain tumor-like protein 3	0	1	0	1
Lethal(3)malignant brain tumor-like protein 1	0	1	0	1
Genome polyprotein	0	1	0	1
Integrin alpha-V	0	1	0	1
Apoptosis regulator Bcl-2	0	1	0	1
Cholecystokinin receptor type A	0	3	1	4
Melanocortin receptor 5	0	2	0	2
Bcl-2-like protein 1	0	1	0	1
Beta-tubulin	0	1	0	1
Chain A, Thymidylate Synthase	0	1	0	1
Chain A, Thymidylate Synthase	0	1	0	1
Chain A, Thymidylate Synthase	0	1	0	1
Serine hydroxymethyltransferase, cytosolic	0	1	1	2
Thymidylate synthase	0	1	0	1
beta-2 adrenergic receptor	1	0	0	1
mu-type opioid receptor isoform MOR-1	0	0	1	1
5-hydroxytryptamine receptor 2A	0	0	1	1
Transforming growth factor beta-1 proprotein	0	1	0	1
Mothers against decapentaplegic homolog 3	0	1	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	2	0	2
Chain A, AKAP9-BRAF fusion protein	0	1	0	1
Serine/threonine-protein kinase B-raf	0	2	0	2
Dual specificity mitogen-activated protein kinase kinase 4	0	0	1	1
Aspartyl/asparaginyl beta-hydroxylase	0	1	0	1
Regulatory protein E2	0	0	1	1
Regulatory protein E2	0	0	1	1
Regulatory protein E2	0	0	1	1
Calcium-activated potassium channel subunit alpha-1	0	1	0	1
Beta-1 adrenergic receptor	0	1	1	3
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Beta-2 adrenergic receptor	0	2	0	3
Beta-1 adrenergic receptor	0	3	1	5
D(3) dopamine receptor	0	1	0	1
Alpha-2B adrenergic receptor	0	0	1	1
Alpha-2C adrenergic receptor	0	0	1	1
Alpha-2A adrenergic receptor	0	0	1	1
Endothelin-1 receptor	0	1	1	2
Beta-3 adrenergic receptor	0	2	0	2
5-hydroxytryptamine receptor 1B	0	2	0	2
Neuromedin-K receptor	0	0	1	1
Type-1 angiotensin II receptor	0	1	1	2
Beta-1 adrenergic receptor	0	1	0	1
Vasopressin V1a receptor	0	1	1	2
5-hydroxytryptamine receptor 7	0	1	0	1
Beta-2 adrenergic receptor	0	1	0	1
Beta-2 adrenergic receptor	0	1	1	3
Nuclear receptor subfamily 2 group E member 1	0	0	2	2
Chain A, RNA-directed RNA polymerase NS5	0	1	0	1
SUMO-1	0	1	0	1
POsterior Segregation	0	0	1	1
chaperonin GroEL	1	0	0	1
Glutamate receptor 1	1	0	0	1
Glutamate receptor 3	1	0	0	1
Glutamate receptor 4	1	0	0	1
Exoribonuclease H	0	1	0	1
Coproheme decarboxylase	0	0	1	1
Protease	0	1	0	1
Single-stranded DNA cytosine deaminase	1	0	0	1
Zinc finger protein mex-5	0	0	1	1
phosphoglycerate kinase	1	0	0	1
Monocarboxylate transporter 4	0	0	0	1
Monocarboxylate transporter 2	0	0	0	1
Monocarboxylate transporter 1	0	0	0	1
C-terminal-binding protein 2	0	1	0	1
Monocarboxylate transporter 2	0	1	0	1
Prolyl 4-hydroxylase	0	1	0	1
Solute carrier organic anion transporter family member 2A1	0	1	0	1
Alpha-ketoglutarate-dependent dioxygenase FTO	0	1	0	1
N	0	1	0	1
cystic fibrosis transmembrane conductance regulator	0	1	0	1
Glutathione reductase, mitochondrial	0	1	0	1
Major prion protein	0	1	0	1
Muscarinic acetylcholine receptor M4	0	1	0	1
Muscarinic acetylcholine receptor M5	0	1	0	1
DNA-directed RNA polymerase subunit alpha	0	1	0	1
DNA-directed RNA polymerase subunit omega	0	1	0	1
DNA-directed RNA polymerase subunit beta'	0	1	0	1
DNA-directed RNA polymerase subunit beta	0	1	0	1
Phospholipase A2, membrane associated	0	1	0	1
Phospholipase A2, membrane associated	0	1	0	1
Acidic phospholipase A2 2	0	1	0	1
Trypanothione reductase	0	2	0	2
D(1A) dopamine receptor	1	0	0	1
Aldehyde oxidase 1	0	1	0	1
Cyclic GMP-AMP synthase	0	1	0	1
2,3-bisphosphoglycerate-independent phosphoglycerate mutase	1	0	0	1
Chain A, PLASMA RETINOL-BINDING PROTEIN PRECURSOR	0	0	1	1
Retinol-binding protein 4	0	0	1	1
Beta-lactoglobulin	0	0	1	1
Sphingosine kinase 2	0	2	0	2
Sphingosine kinase 1	0	1	0	1
Low-density lipoprotein receptor	0	1	0	1
Fibronectin	0	1	0	1
Macrophage colony-stimulating factor 1 receptor	0	1	0	1
Multidrug resistance-associated protein 1	0	1	0	1
Proprotein convertase subtilisin/kexin type 9	0	1	0	1
Chain A, Lysr-type Regulatory Protein	0	0	1	1
Chain A, Lysr-type Regulatory Protein	0	0	1	1
Chain A, Lysr-type Regulatory Protein	0	0	1	1
Chain A, 146aa long hypothetical transcriptional regulator	0	0	1	1
Chain A, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain A, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain A, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain B, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain C, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain A, Anthranilate phosphoribosyltransferase	0	1	0	1
Anthranilate phosphoribosyltransferase	0	1	0	1
Estrogen receptor beta	0	0	0	1
5'-AMP-activated protein kinase subunit beta-2	0	0	0	1
Polymerase acidic protein	0	0	1	1
Tyrosine-protein phosphatase YopH	0	1	0	1
Prolyl 4-hydroxylase subunit alpha-1	0	1	0	1
Estrogen receptor	0	0	0	1
Cystathionine gamma-lyase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Solute carrier family 22 member 7	0	0	0	1
Ubiquitin-like domain-containing CTD phosphatase 1	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-3	0	0	0	1
5'-AMP-activated protein kinase subunit beta-1	0	0	0	1
photoreceptor-specific nuclear receptor	0	1	0	1
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	2	0	2
Insulin receptor	0	1	0	1
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	1	0	1
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	1	0	1
Eukaryotic translation initiation factor 4E	0	0	1	1
Peptidyl-prolyl cis-trans isomerase FKBP1A	0	1	0	1
Peptidyl-prolyl cis-trans isomerase FKBP1A	0	4	2	6
Peptidyl-prolyl cis-trans isomerase FKBP1B	0	0	2	2
Peptidyl-prolyl cis-trans isomerase FKBP5	0	2	0	2
Programmed cell death protein 4	0	0	1	1
Serine/threonine-protein kinase mTOR	0	1	0	1
Chain A, Mitogen-activated protein kinase 14	0	0	1	1
Chain A, Mitogen-activated protein kinase 14	0	0	1	1
Chain A, Mitogen-activated protein kinase 14	0	0	1	1
Chain A, Mitogen-activated protein kinase 14	0	0	1	1
Chain A, Mitogen-activated protein kinase 14	0	0	1	1
Chain A, Mitogen-activated protein kinase 14	0	0	1	1
Chain A, Mitogen-activated protein kinase 14	0	0	1	1
Chain A, VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2	0	1	0	1
Chain A, VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2	0	1	0	1
Chain A, VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2	0	1	0	1
Chain A, VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2	0	1	0	1
Chain A, VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2	0	1	0	1
melanocortin receptor 4	0	1	1	2
Platelet-derived growth factor receptor beta	0	2	0	2
Cyclin-C	0	1	1	2
Vascular endothelial growth factor receptor 3	0	1	0	1
Vascular endothelial growth factor receptor 2	0	1	0	1
Protein delta homolog 1	0	1	2	3
Vascular endothelial growth factor receptor 2	0	1	0	1
RuvB-like 2	0	1	1	2
RuvB-like 1	0	1	0	1
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	2	0	3
Mast/stem cell growth factor receptor Kit	0	1	0	1
Translocator protein	0	1	0	1
Beta-adrenergic receptor kinase 1	0	1	0	1
Platelet-derived growth factor receptor alpha	0	1	0	1
G protein-coupled receptor kinase 5	0	1	0	1
Serine/threonine-protein kinase ULK3	0	0	1	1
Bromodomain-containing protein 9	0	0	1	1
Serine/threonine-protein kinase 3	0	0	1	1
Bromodomain-containing protein 7	0	0	1	1
Complement C5	0	0	1	1
Aldo-keto reductase family 1 member B1	0	1	0	1
Peroxisome proliferator-activated receptor gamma	0	0	2	2
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	0	1	0	1
Splicing factor 3B subunit 3	0	1	0	1
Retinoic acid receptor alpha	0	2	3	8
Retinoic acid receptor beta	0	2	3	8
Retinoic acid receptor gamma	0	2	3	8
cGMP-gated cation channel alpha-1	0	0	1	1
Sodium channel protein type 7 subunit alpha	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	1	0	1
Sodium channel protein type 8 subunit alpha	0	1	0	1
Luciferin 4-monooxygenase	0	0	1	1
Ras guanyl-releasing protein 3	0	0	1	1
Thymidine kinase	0	1	0	2
Thymidine kinase, cytosolic	0	2	0	4
Thymidine kinase	0	1	0	2
Thymidine phosphorylase	0	0	0	1
Thymidine phosphorylase	0	0	0	1
Thymidylate kinase	0	1	0	1
Thymidine kinase, cytosolic	0	0	0	2
Thymidine kinase	0	0	0	1
Thymidylate kinase	0	1	0	1
Thymidine kinase	0	1	0	2
Sterol O-acyltransferase 1	0	1	0	1
Thymidine kinase	0	0	0	1
Thymidine kinase	0	0	0	1
Chain A, Nuclear Receptor ROR-beta	0	1	0	1
Alpha-1A adrenergic receptor	0	1	0	1
Retinoic acid receptor RXR-beta	0	2	2	4
Nuclear receptor ROR-alpha	0	1	0	1
Retinoic acid receptor RXR-gamma	0	2	2	4
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	0	2	1	3
Indoleamine 2,3-dioxygenase 2	0	1	0	1
Nuclear receptor ROR-beta	0	1	0	1
procathepsin L isoform 1 preproprotein	0	1	0	1
Chain A, enoyl-acyl carrier reductase	0	1	0	1
Chain C, enoyl-acyl carrier reductase	0	1	0	1
Chain A, enoyl-acyl carrier reductase	0	1	0	1
Chain C, enoyl-acyl carrier reductase	0	1	0	1
Chain A, enoyl-acyl carrier reductase	0	1	0	1
Chain C, enoyl-acyl carrier reductase	0	1	0	1
Chain A, Repressor	0	0	1	1
3-oxoacyl-[acyl-carrier-protein] synthase 3	0	1	0	1
twin arginine protein translocation system - TatA protein	0	0	0	1
Enoyl-[acyl-carrier-protein] reductase [NADH] FabI	0	1	0	1
DNA gyrase subunit A	0	1	0	1
DNA gyrase subunit B	0	1	0	1
Endoplasmic reticulum chaperone BiP	0	1	0	1
Carbonyl reductase [NADPH] 1	0	2	0	2
Enoyl-[acyl-carrier-protein] reductase [NADH] FabI	0	1	0	1
Enoyl-[acyl-carrier-protein] reductase [NADH] FabI	0	1	0	1
Enoyl-[acyl-carrier-protein] reductase [NADPH] FabI	0	2	0	2
Enoyl-acyl carrier reductase	0	1	0	1
Enoyl-acyl-carrier protein reductase	0	2	0	2
Enoyl-ACP reductase II	0	1	0	1
Sterol 14-alpha-demethylase	0	0	1	1
14-alpha sterol demethylase	0	0	1	1
Cholesterol side-chain cleavage enzyme, mitochondrial	0	0	1	1
Lanosterol 14-alpha demethylase	0	0	1	1
Sterol 14-alpha demethylase	0	0	1	1
14-alpha sterol demethylase	0	0	1	1
14-alpha sterol demethylase	0	0	1	1
Cholesterol 24-hydroxylase	0	2	1	3
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(1)

Research Excerpts

Overview

Context

Treatment

Research

Studies (1,016)

Protein Targets (1,783)

Keratosis, Actinic

Synonyms(1)

Research Excerpts

Overview

Context

Treatment

Research

Studies (1,016)

Drugs Studied (207)

Protein Targets (1,783)