Page last updated: 2024-09-28

Locomotor Ataxia

Parenchymatous NEUROSYPHILIS marked by slowly progressive degeneration of the posterior columns, posterior roots, and ganglia of the spinal cord. The condition tends to present 15 to 20 years after the initial infection and is characterized by lightening-like pains in the lower extremities, URINARY INCONTINENCE; ATAXIA; severely impaired position and vibratory sense, abnormal gait (see GAIT DISORDERS, NEUROLOGIC), OPTIC ATROPHY; Argyll-Robertson pupils, hypotonia, hyperreflexia, and trophic joint degeneration (Charcot's Joint; see ARTHROPATHY, NEUROGENIC). (From Adams et al., Principles of Neurology, 6th ed, p726)

Synonyms(9)

Synonym
Tabes Spinalis
Spinal Meningovascular Syphilis
Tabetic Neurosyphilis
Syphilitic Meningomyelitis
Syphilis, Spinal Cord
Tabes Dorsalis
Locomotor Ataxia
Spinal Cord Syphilis
Myelosyphilis

Research Excerpts

Research

Studies (89)

TimeframeStudies, This Condition (%)All Conditions %
pre-199071 (79.78)23.3326
1990's1 (1.12)12.5806
2000's4 (4.49)18.1394
2010's11 (12.36)28.8240
2020's2 (2.25)9.53
DrugIndicatedRelationship StrengthStudiesTrials
gamma-aminobutyric acid0low10
iodine0low10
dihydroxyphenylalanine0low10
niacin0low10
thiamine0low10
phenytoin0medium41
hydroxyindoleacetic acid0low10
baclofen0medium11
carbamazepine0medium92
valproic acid0low10
gabapentin0low10
guanethidine0low10
2-propanol0low10
midodrine0low10
probenecid0low10
procaine0low40
sulfamethazine0low10
prednisolone0low10
prednisone0low10
penicillin g0low110
lysine0low10
cyanides0low10
physostigmine0low10
phenylephrine0low10
tryptophan0low10
benzathine0low10
ephedrine0low10
hydantoins0low10
alpha-aminopyridine0low10
oxophenarsine0low10
diphenyldiselenide0low10
streptomycin0low20
manganese0low10
tricalcium phosphate0low10
trolamine salicylate0low80
tramadol0low10
substance p0medium21
fomesafen0low70
nsc-1727550low10
cortisone0low60
bradykinin0low10
cocaine0low10
roflumilast0low10
arsphenamine0low30
enkephalin, leucine0low10
pyrophosphate0low10
myelin basic protein0low10
bismuth0low30
arsenic0low20
pregabalin0low10
nitrofurantoin0low10
butylscopolammonium bromide0low10
pituitrin0low10
ro13-99040low10
tetracycline0low10
vitamin b 120low20
eye0low50

Protein Targets (827)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
hypoxia-inducible factor 1 alpha subunit5005
RAR-related orphan receptor gamma110011
GLI family zinc finger 3120012
AR protein160016
aldehyde dehydrogenase 1 family, member A1110011
retinoic acid nuclear receptor alpha variant 1130013
retinoid X nuclear receptor alpha9009
estrogen nuclear receptor alpha190019
peroxisome proliferator-activated receptor delta5005
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a110011
activating transcription factor 63003
v-jun sarcoma virus 17 oncogene homolog (avian)7007
Histone H2A.x4004
thyroid hormone receptor beta isoform a6006
heat shock protein beta-14004
nuclear factor erythroid 2-related factor 2 isoform 1130013
lamin isoform A-delta10130013
Voltage-dependent calcium channel gamma-2 subunit7007
Glutamate receptor 28008
thyroid stimulating hormone receptor3003
thyroid hormone receptor beta isoform 26006
Heat shock protein HSP 90-alpha0011
Botulinum neurotoxin type A 0101
Neutrophil cytosol factor 10101
Nitric oxide synthase, endothelial0101
Nitric oxide synthase, brain0101
Nitric oxide synthase, brain 0102
Nitric oxide synthase, inducible0102
Kappa-type opioid receptor0113
Phosphatidylinositol 4-kinase alpha0101
Mu-type opioid receptor0314
Tyrosine-protein kinase 0011
Phosphatidylinositol 4-kinase type 2-beta0101
Phosphatidylinositol 4-kinase type 2-alpha0101
Phosphatidylinositol 4-kinase beta0101
thioredoxin reductase110011
phosphopantetheinyl transferase4004
ATAD5 protein, partial4004
NFKB1 protein, partial4004
regulator of G-protein signaling 46006
67.9K protein3003
euchromatic histone-lysine N-methyltransferase 2130013
Bloom syndrome protein isoform 17007
D(1A) dopamine receptor4004
cytochrome P450 3A4 isoform 15005
histone acetyltransferase KAT2A isoform 16006
Gamma-aminobutyric acid receptor subunit pi5308
ATP-binding cassette sub-family C member 30909
Multidrug resistance-associated protein 40909
Gamma-aminobutyric acid type B receptor subunit 20224
Gamma-aminobutyric acid type B receptor subunit 20303
Bile salt export pump018018
Gamma-aminobutyric acid receptor subunit beta-15308
Gamma-aminobutyric acid receptor subunit delta5308
Gamma-aminobutyric acid receptor subunit gamma-253210
Gamma-aminobutyric acid receptor subunit alpha-55308
Gamma-aminobutyric acid receptor subunit alpha-35308
Gamma-aminobutyric acid receptor subunit gamma-15308
Gamma-aminobutyric acid receptor subunit alpha-25308
Gamma-aminobutyric acid receptor subunit alpha-45308
Gamma-aminobutyric acid receptor subunit gamma-35308
Gamma-aminobutyric acid receptor subunit alpha-65308
Gamma-aminobutyric acid receptor subunit alpha-153210
Gamma-aminobutyric acid receptor subunit beta-35308
Gamma-aminobutyric acid receptor subunit beta-253210
GABA theta subunit5308
Canalicular multispecific organic anion transporter 1010010
Gamma-aminobutyric acid receptor subunit epsilon5308
Gamma-aminobutyric acid type B receptor subunit 10224
Gamma-aminobutyric acid type B receptor subunit 10202
ATP-dependent phosphofructokinase5005
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE5005
Chain A, TYROSYL-DNA PHOSPHODIESTERASE8008
DNA polymerase kappa isoform 15005
Angiotensin-converting enzyme 0001
B2 bradykinin receptor0101
B2 bradykinin receptor0215
B1 bradykinin receptor0101
Olfactory receptor 51E20011
Chain A, Beta-lactamase2002
USP1 protein, partial8008
nuclear receptor subfamily 1, group I, member 38008
cytochrome P450 2D64004
IDH17007
chromobox protein homolog 17007
geminin100010
acetylcholinesterase7007
TDP1 protein100010
thyroid stimulating hormone receptor9009
glucocorticoid receptor [Homo sapiens]130013
estrogen-related nuclear receptor alpha140014
pregnane X nuclear receptor120012
nuclear factor erythroid 2-related factor 2 isoform 24004
mitogen-activated protein kinase 13003
Vpr1001
Bile salt export pump0707
Albumin0022
Major prion protein0022
Cellular tumor antigen p537007
Sodium channel protein type 1 subunit alpha0101
Sodium channel protein type 2 subunit alpha0202
Sodium channel protein type 3 subunit alpha0101
Cytochrome P450 2C9 0516
UDP-glucuronosyltransferase 2B70103
Cytochrome P450 2B60011
Sodium channel protein type 4 subunit alpha0305
Cytochrome P450 2J20303
Potassium voltage-gated channel subfamily H member 20505
Sodium channel protein type 9 subunit alpha0404
Frizzled-80011
P2X purinoceptor 40101
Proteasome subunit beta type-110001
Fumarate hydratase3003
Microtubule-associated protein tau5005
Thrombopoietin1001
Smad32002
caspase 7, apoptosis-related cysteine protease1001
estrogen receptor 2 (ER beta)3003
progesterone receptor9009
NADPH oxidase 10101
cytochrome P450 family 3 subfamily A polypeptide 45005
farnesoid X nuclear receptor3003
G3003
polyprotein3003
peroxisome proliferator activated receptor gamma8008
vitamin D (1,25- dihydroxyvitamin D3) receptor7007
Snq2p0001
caspase-31001
Adenylate cyclase type 1 0202
Caspase-71001
Spike glycoprotein0112
Replicase polyprotein 1ab0112
cytochrome P450 2D6 isoform 12002
cellular tumor antigen p53 isoform a1001
vitamin D3 receptor isoform VDRA4004
potassium voltage-gated channel subfamily H member 2 isoform d4004
caspase-31001
histone deacetylase 9 isoform 32002
atrial natriuretic peptide receptor 2 precursor1001
ras-related protein Rab-9A3003
serine/threonine-protein kinase mTOR isoform 11001
peripheral myelin protein 224004
survival motor neuron protein isoform d7007
M-phase phosphoprotein 85005
muscarinic acetylcholine receptor M15005
lethal factor (plasmid)2002
Proteasome subunit alpha type-70001
Solute carrier family 22 member 1 0304
Polyunsaturated fatty acid lipoxygenase ALOX15B1001
Transmembrane protease serine 20112
Glutamate receptor ionotropic, NMDA 2D0101
Transient receptor potential cation channel subfamily V member 10101
Glutamate receptor ionotropic, NMDA 3B0101
Voltage-dependent L-type calcium channel subunit alpha-1F0202
5-hydroxytryptamine receptor 40202
Potassium channel subfamily K member 20101
Epidermal growth factor receptor0202
Interferon beta4004
HLA class I histocompatibility antigen, B alpha chain 3003
Albumin0011
Sarcoplasmic/endoplasmic reticulum calcium ATPase 10101
Receptor tyrosine-protein kinase erbB-20101
Major prion protein0011
Integrin beta-31001
Cytochrome P450 1A20011
Tyrosine-protein kinase Fyn0101
Procathepsin L0112
Aldo-keto reductase family 1 member B10303
Muscarinic acetylcholine receptor M20303
Muscarinic acetylcholine receptor M40202
ATP-dependent translocase ABCB10102
Muscarinic acetylcholine receptor M10202
Muscarinic acetylcholine receptor M30101
Muscarinic acetylcholine receptor M40101
Integrin alpha-IIb1001
5-hydroxytryptamine receptor 1A0101
5-hydroxytryptamine receptor 2C0404
Muscarinic acetylcholine receptor M50101
Muscarinic acetylcholine receptor M50202
Alpha-2A adrenergic receptor0314
Replicase polyprotein 1a0112
Replicase polyprotein 1ab0112
Replicase polyprotein 1ab0112
Cys-loop ligand-gated ion channel0101
Calmodulin-10213
Replicase polyprotein 1ab0112
Cytochrome P450 2D60213
Muscarinic acetylcholine receptor M20202
Muscarinic acetylcholine receptor M10202
Polyunsaturated fatty acid lipoxygenase ALOX150101
Angiotensin-converting enzyme0202
D(2) dopamine receptor0203
5-hydroxytryptamine receptor 2A0404
Alpha-1B adrenergic receptor0505
Sphingomyelin phosphodiesterase0101
Alpha-2B adrenergic receptor0303
Alpha-2C adrenergic receptor0314
D0303
D(3) dopamine receptor0202
5-hydroxytryptamine receptor 1A0404
Alpha-2B adrenergic receptor0404
D(2) dopamine receptor0101
Muscarinic acetylcholine receptor M30202
Proteasome subunit beta type-10001
Substance-K receptor0404
D(1A) dopamine receptor0203
D(4) dopamine receptor0203
D(1B) dopamine receptor0102
Adenylate cyclase type 30202
Alpha-2C adrenergic receptor0404
UDP-glucuronosyltransferase 1A40001
Alpha-2A adrenergic receptor0404
Alpha-1D adrenergic receptor0505
Sodium-dependent noradrenaline transporter 0606
Sodium-dependent dopamine transporter0404
Histamine H2 receptor0202
Alpha-1D adrenergic receptor0202
D(1B) dopamine receptor0202
Proteasome subunit alpha type-10001
Proteasome subunit alpha type-20001
Proteasome subunit alpha type-30001
Proteasome subunit alpha type-40001
Adenylate cyclase type 20202
Adenylate cyclase type 40202
Proteasome subunit beta type-80001
Proteasome subunit beta type-90001
Proteasome subunit alpha type-50001
Proteasome subunit beta type-40001
Proteasome subunit beta type-60001
Proteasome subunit beta type-50001
5-hydroxytryptamine receptor 2A0202
5-hydroxytryptamine receptor 2C0202
5-hydroxytryptamine receptor 1B0303
Trypanothione reductase0202
D(4) dopamine receptor0202
5-hydroxytryptamine receptor 2B0404
Histamine H1 receptor0112
Sodium-dependent serotonin transporter0404
Melanocortin receptor 40202
5-hydroxytryptamine receptor 7 0202
Melanocortin receptor 50202
Pleiotropic ABC efflux transporter of multiple drugs0102
5-hydroxytryptamine receptor 70101
Histamine H1 receptor0202
Mu-type opioid receptor0527
Glutamate receptor ionotropic, NMDA 1 0203
D(3) dopamine receptor0203
Sodium channel protein type 1 subunit alpha0202
Adenylate cyclase type 80202
Proteasome subunit beta type-100001
Delta-type opioid receptor0415
Kappa-type opioid receptor0415
5-hydroxytryptamine receptor 2B0202
Melanocortin receptor 30202
Alpha-1A adrenergic receptor0505
Histamine H2 receptor3003
Proteasome subunit beta type-30001
Proteasome subunit beta type-20001
D(1A) dopamine receptor1001
5-hydroxytryptamine receptor 60202
5-hydroxytryptamine receptor 70101
Gastrin/cholecystokinin type B receptor0101
Spike glycoprotein1113
Proteasome subunit alpha type-60012
D(2) dopamine receptor0315
Calmodulin 0112
Aldehyde oxidase 10101
Glutamate receptor ionotropic, NMDA 2A 0203
Glutamate receptor ionotropic, NMDA 2B0203
Glutamate receptor ionotropic, NMDA 2C0203
Sodium channel protein type 7 subunit alpha0101
Voltage-dependent L-type calcium channel subunit alpha-1D 0202
Sodium-dependent dopamine transporter 0404
Adenylate cyclase type 60202
Adenylate cyclase type 50202
Glutamate receptor ionotropic, NMDA 10101
Aldehyde oxidase0202
Glutamate receptor ionotropic, NMDA 2A0101
Glutamate receptor ionotropic, NMDA 2B0101
Voltage-dependent L-type calcium channel subunit alpha-1S0202
Voltage-dependent L-type calcium channel subunit alpha-1C0202
Sodium channel protein type 5 subunit alpha0202
Glutamate receptor ionotropic, NMDA 2C0101
Glutamate receptor ionotropic, NMDA 2D0203
Nuclear receptor subfamily 3 group C member 3 0202
Adenylyl cyclase 7 0202
Proteasome subunit alpha-type 80001
Glutamate receptor ionotropic, NMDA 3A0101
Glutamate receptor ionotropic, NMDA 3B0203
Inositol hexakisphosphate kinase 13003
D0101
Sodium channel protein type 2 subunit alpha0202
Proteasome subunit beta type-70001
Ataxin-25005
Sigma non-opioid intracellular receptor 10505
Angiotensin-converting enzyme 2 0112
Sodium channel protein type 3 subunit alpha0202
Glutamate receptor ionotropic, NMDA 3A0203
Sodium channel protein type 11 subunit alpha0101
Sodium channel protein type 8 subunit alpha0101
Histamine H3 receptor0101
Sodium channel protein type 10 subunit alpha0101
cytochrome P450 2C9, partial3003
cAMP-specific 3',5'-cyclic phosphodiesterase 4A0303
P2Y purinoceptor 120202
Protein-arginine deiminase type-40505
Chain A, CHIMERA OF IG KAPPA CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION0011
Chain B, CHIMERA OF IG GAMMA-1 CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION0011
Chain H, Fab M82G2, Heavy chain0011
Chain L, Fab M82G2, Light chain0011
Chain H, Fab M82g2, Heavy Chain0011
Chain L, Fab M82g2, Light Chain0011
Gamma-aminobutyric acid receptor subunit pi0303
Gamma-aminobutyric acid receptor subunit delta0303
Amyloid-beta precursor protein0202
Fatty acid-binding protein, heart0101
Muscarinic acetylcholine receptor M20101
Tryptophan 5-hydroxylase 10101
Gamma-aminobutyric acid receptor subunit alpha-10314
Gamma-aminobutyric acid receptor subunit beta-10314
Gamma-aminobutyric acid receptor subunit gamma-20314
Liver carboxylesterase 10102
Gamma-aminobutyric acid receptor subunit beta-30314
5-hydroxytryptamine receptor 1D0101
5-hydroxytryptamine receptor 1F0101
5-hydroxytryptamine receptor 60101
Gamma-aminobutyric acid receptor subunit alpha-50314
Sodium-dependent serotonin transporter0304
Gamma-aminobutyric acid receptor subunit alpha-30314
5-hydroxytryptamine receptor 5A0101
5-hydroxytryptamine receptor 5B0101
5-hydroxytryptamine receptor 3A0101
Lysosomal Pro-X carboxypeptidase0101
Gamma-aminobutyric acid receptor subunit alpha-20314
Gamma-aminobutyric acid receptor subunit beta-20314
Gamma-aminobutyric acid receptor subunit alpha-40314
Gamma-aminobutyric acid receptor subunit epsilon0303
cAMP-specific 3',5'-cyclic phosphodiesterase 4B0303
cAMP-specific 3',5'-cyclic phosphodiesterase 4D0202
Leukotriene B4 receptor 10101
Gamma-aminobutyric acid receptor subunit alpha-60314
Sodium-dependent dopamine transporter0202
5-hydroxytryptamine receptor 4 0101
Gamma-aminobutyric acid receptor subunit gamma-10303
Gamma-aminobutyric acid receptor subunit gamma-30303
5-hydroxytryptamine receptor 3B0101
Leukotriene B4 receptor 20101
Gamma-aminobutyric acid receptor subunit theta0303
Transporter0202
Chain A, HADH2 protein3003
Chain B, HADH2 protein3003
endonuclease IV4004
dopamine D1 receptor2002
pregnane X receptor3003
GLS protein5005
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a3003
peripheral myelin protein 22 isoform 14004
atrial natriuretic peptide receptor 1 precursor3003
flap endonuclease 13003
Glucocorticoid receptor08215
Sex hormone-binding globulin0011
Glycine receptor subunit alpha-10808
Corticosteroid-binding globulin0202
Glycine receptor subunit beta0808
Glycine receptor subunit alpha-20808
Glycine receptor subunit alpha-30808
Potassium voltage-gated channel subfamily A member 10011
TAR DNA-binding protein 432002
Multidrug and toxin extrusion protein 10202
Carbonic anhydrase 10608
Carbonic anhydrase 20619
Carbonic anhydrase 40203
Carbonic anhydrase0304
Carbonic anhydrase 150203
Chain A, Putative fructose-1,6-bisphosphate aldolase5005
Chain A, 2-oxoglutarate Oxygenase4004
Chain A, ATP-DEPENDENT DNA HELICASE Q11001
15-lipoxygenase, partial1001
polyunsaturated fatty acid lipoxygenase ALOX121001
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 12002
runt-related transcription factor 1 isoform AML1b1001
core-binding factor subunit beta isoform 21001
Glutamate receptor 11001
Glutamate receptor 31001
Glutamate receptor 41001
Caspase-72002
Gamma-butyrobetaine dioxygenase0112
Histone-lysine N-methyltransferase EHMT20101
Histone-lysine N-methyltransferase EHMT10101
Opioid receptor, delta 1b 0101
Opioid receptor homologue0101
Proenkephalin-B0011
Delta-type opioid receptor0416
Delta-type opioid receptor0202
Kappa-type opioid receptor0101
Mu-type opioid receptor0202
Kappa-type opioid receptor0101
Mu-type opioid receptor0101
Mu-type opioid receptor0101
Luciferase3003
thioredoxin glutathione reductase5005
EWS/FLI fusion protein6006
ubiquitin carboxyl-terminal hydrolase 2 isoform a2002
Voltage-dependent calcium channel subunit alpha-2/delta-10101
Chain A, Ferritin light chain1001
Gamma-aminobutyric acid 0112
Gamma-aminobutyric acid receptor subunit rho-30011
Hsf1 protein0011
bromodomain adjacent to zinc finger domain 2B4004
arylsulfatase A4004
transcriptional regulator ERG isoform 32002
histone-lysine N-methyltransferase 2A isoform 2 precursor2002
neuropeptide S receptor isoform A2002
Histone deacetylase 30303
Gamma-aminobutyric acid receptor subunit alpha-60112
Gamma-aminobutyric acid receptor subunit gamma-20112
Gamma-aminobutyric acid receptor subunit delta0112
Sodium- and chloride-dependent GABA transporter 10101
Gamma-aminobutyric acid receptor subunit rho-10022
Gamma-aminobutyric acid receptor subunit alpha-20112
Gamma-aminobutyric acid receptor subunit alpha-30112
Gamma-aminobutyric acid receptor subunit gamma-30112
Gamma-aminobutyric acid receptor subunit rho-20011
Sodium- and chloride-dependent GABA transporter 10101
Sodium- and chloride-dependent taurine transporter0101
Sodium- and chloride-dependent GABA transporter 20101
Sodium- and chloride-dependent GABA transporter 30101
Sodium- and chloride-dependent GABA transporter 10101
Sodium- and chloride-dependent GABA transporter 20101
Sodium- and chloride-dependent GABA transporter 30101
Sodium- and chloride-dependent betaine transporter0101
Sodium- and chloride-dependent betaine transporter0101
Sodium- and chloride-dependent GABA transporter 30101
Gamma-aminobutyric acid receptor subunit beta-10112
Histone deacetylase 40303
Gamma-aminobutyric acid receptor subunit alpha-10112
Gamma-aminobutyric acid receptor subunit beta-30112
4-aminobutyrate aminotransferase, mitochondrial0001
4-aminobutyrate aminotransferase, mitochondrial0001
Histone deacetylase 10303
Sterol O-acyltransferase 10011
Proton-coupled amino acid transporter 10101
Gamma-aminobutyric acid receptor subunit alpha-50112
Gamma-aminobutyric acid receptor subunit pi0112
Histone deacetylase 70303
Histone deacetylase 20303
Polyamine deacetylase HDAC100303
Histone deacetylase 11 0303
Histone deacetylase 80303
Gamma-aminobutyric acid receptor subunit alpha-40112
Platelet glycoprotein VI0011
Gamma-aminobutyric acid receptor subunit theta0112
Sodium- and chloride-dependent GABA transporter 20101
Gamma-aminobutyric acid receptor subunit gamma-10112
Histone deacetylase 60303
Histone deacetylase 90303
Histone deacetylase 50303
DNA polymerase beta1001
DNA polymerase iota isoform a (long)3003
Glycogen synthase kinase-3 alpha0101
Glycogen synthase kinase-3 beta0101
Protein cereblon0202
hypothetical protein, conserved1001
alpha-galactosidase2002
cytochrome P450 2C9 precursor2002
urokinase-type plasminogen activator precursor1001
plasminogen precursor1001
urokinase plasminogen activator surface receptor precursor1001
Uracil nucleotide/cysteinyl leukotriene receptor0202
aryl hydrocarbon receptor5005
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast0101
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast0101
Glutathione reductase, mitochondrial0202
Cationic amino acid transporter 30101
PPM1D protein1001
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)4004
nonstructural protein 12002
nuclear receptor subfamily 1, group I, member 22002
muscleblind-like protein 1 isoform 12002
Nuclear receptor subfamily 1 group I member 20011
Androgen receptor0303
ATPase family AAA domain-containing protein 54004
Nuclear receptor subfamily 1 group I member 20011
Chain A, JmjC domain-containing histone demethylation protein 3A1001
glp-1 receptor, partial3003
thyrotropin-releasing hormone receptor1001
lysosomal alpha-glucosidase preproprotein1001
Polyphenol oxidase 20101
Neuronal acetylcholine receptor subunit alpha-41001
Cholesteryl ester transfer protein0101
Neuronal acetylcholine receptor subunit beta-21001
D-amino-acid oxidase0101
Xanthine dehydrogenase/oxidase0101
Hydroxycarboxylic acid receptor 30011
Nicotinamidase0101
Hydroxycarboxylic acid receptor 20011
Hydroxycarboxylic acid receptor 20213
D-aspartate oxidase0101
Hydroxycarboxylic acid receptor 20112
SMAD family member 21001
SMAD family member 31001
glucocerebrosidase1001
streptokinase A precursor0022
Estrogen receptor0011
Nuclear receptor ROR-gamma3003
60 kDa chaperonin 0101
Estrogen receptor beta0011
10 kDa chaperonin 0101
CDGSH iron-sulfur domain-containing protein 10202
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Metallo-beta-lactamase type 20001
Metallo-beta-lactamase VIM-11 0001
Beta-lactamase 0001
Metallo-beta-lactamase VIM-20001
Beta-lactamase 0001
Metallo-beta-lactamase VIM-19 0001
Beta-lactamase 0001
Beta-lactamase 0001
Metallo-beta-lactamase0001
Beta-lactamase 0001
Solute carrier family 22 member 60202
Beta-lactamase0001
Solute carrier family 22 member 80203
Beta-lactamase0001
Beta-lactamase 10001
Beta-lactamase0001
Beta-lactamase SHV-10001
Beta-lactamase SHV-10001
Beta-lactamase OXA-100001
Beta-lactamase0001
Beta-lactamase0001
Solute carrier family 15 member 10101
Beta-lactamase TEM0102
Guanine nucleotide-binding protein G1001
Beta-lactamase0001
B2 metallo-beta-lactamase 0001
Solute carrier family 15 member 20101
Metallo-beta-lactamase VIM-130001
Beta-lactamase 0001
Beta-lactamase 0001
Efflux transporter 0001
Beta-lactamase 0001
Metallo-beta-lactamase VIM-20001
Beta-lactamase Toho-10001
Beta-lactamase 0001
Beta-lactamase 0001
Class D beta-lactamase0001
Beta-lactamase 0001
Solute carrier family 15 member 20101
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Metallo-b-lactamase 0001
Beta-lactamase IMP-1 0001
BlaVIM-1 0001
Beta-lactamase 0001
Beta-lactamase 0001
Solute carrier family 22 member 80304
Beta-lactamase 0001
Carbapenem-hydrolyzing beta-lactamase KPC0001
Beta-lactamase class B VIM-2 0001
Beta-lactamase 0001
Solute carrier family 22 member 80304
Beta-lactamase VIM-1 0001
Alpha-1B adrenergic receptor 0011
Beta-2 adrenergic receptor0011
Beta-1 adrenergic receptor0011
Beta-3 adrenergic receptor0011
POU domain, class 2, transcription factor 10001
Beta-1 adrenergic receptor0101
Alpha-1A adrenergic receptor0112
Alpha-1B adrenergic receptor0101
Alpha-2B adrenergic receptor0001
Alpha-1A adrenergic receptor0112
Alpha-1B adrenergic receptor0112
Alpha-2C adrenergic receptor0001
Alpha-2A adrenergic receptor0001
parathyroid hormone/parathyroid hormone-related peptide receptor precursor1001
nuclear receptor ROR-gamma isoform 12002
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Dihydrofolate reductase 0101
Aldo-keto reductase family 1 member B10101
Inositol monophosphatase 11001
hexokinase-4 isoform 11001
glucokinase regulatory protein1001
Acetylcholinesterase0203
Acetylcholinesterase0101
Cholinesterase0303
Acetylcholinesterase0101
Acetylcholinesterase0203
Acetylcholinesterase 0101
Acetylcholinesterase0101
Acetylcholinesterase0101
Cholinesterase0203
Cholinesterase0101
Acyl-CoA:cholesterol acyltransferase 0101
Carboxylic ester hydrolase 0101
Carboxylic ester hydrolase 0101
luciferase0001
Fatty acid-binding protein, liver0101
Estrogen receptor0202
Progesterone receptor0203
Glucocorticoid receptor0112
Glucocorticoid receptor0011
Mineralocorticoid receptor 0213
Androgen receptor0202
Glutamine synthetase0011
Prostaglandin G/H synthase 20101
Nociceptin receptor0011
Estrogen receptor beta0202
Voltage-dependent calcium channel subunit alpha-2/delta-10102
Voltage-dependent calcium channel subunit alpha-2/delta-20101
Solute carrier organic anion transporter family member 1A40101
Carbonic anhydrase 120203
UDP-glucuronosyltransferase 1A90102
Transient receptor potential cation channel subfamily A member 10011
UDP-glucuronosyltransferase 1-60102
UDP-glucuronosyltransferase 1A1 0101
Solute carrier organic anion transporter family member 1A10101
Carbonic anhydrase 90304
Solute carrier family 22 member 60202
Solute carrier family 22 member 70101
Solute carrier family 22 member 10202
Canalicular multispecific organic anion transporter 10101
Solute carrier family 22 member 200101
Solute carrier family 22 member 60101
Pannexin-10101
Solute carrier family 22 member 120101
Solute carrier organic anion transporter family member 1C10101
UDP-glucuronosyltransferase 1A70101
UDP-glucuronosyltransferase 1A100101
Pannexin-10101
Solute carrier family 22 member 110203
Solute carrier family 22 member 20202
Solute carrier family 22 member 70203
Chain A, dATP pyrophosphohydrolase0101
Chain A, Adenylate cyclase type 50101
Chain B, Adenylate cyclase type 20101
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B0101
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B0101
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B0101
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B0101
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B0101
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B0101
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4D0101
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4D0101
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4D0101
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4D0101
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B0101
Chain B, cAMP-specific 3',5'-cyclic phosphodiesterase 4B0101
Chain A, cGMP-specific 3',5'-cyclic phosphodiesterase0101
Chain A, cGMP-specific 3',5'-cyclic phosphodiesterase0101
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B0101
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4D0101
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4D0101
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4D0101
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4D0101
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4D0101
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4D0101
cGMP-dependent 3',5'-cyclic phosphodiesterase0101
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A0101
cGMP-specific 3',5'-cyclic phosphodiesterase0101
Adenosine receptor A2a0101
Adenosine receptor A2b0101
Adenosine receptor A10101
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4C0101
cGMP-inhibited 3',5'-cyclic phosphodiesterase B0101
cGMP-inhibited 3',5'-cyclic phosphodiesterase A0101
Beta-2 adrenergic receptor0101
Phosphodiesterase 0101
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A0101
cAMP-specific 3',5'-cyclic phosphodiesterase 7B0101
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A0101
Enoyl-[acyl-carrier-protein] reductase [NADH]0001
Substance-P receptor0202
Neuromedin-K receptor0011
Substance-K receptor0112
Substance-P receptor0213
Neuromedin-K receptor0112
Substance-P receptor0202
Substance-K receptor0101
Substance-K receptor0101
Growth hormone secretagogue receptor type 10011
Mas-related G-protein coupled receptor member X20011
interleukin 81001
Carbonic anhydrase 0001
Carbonic anhydrase 0101
Carbonic anhydrase 0101
Carbonic anhydrase 0101
Carbonic anhydrase0101
Carbonic anhydrase0101
Carbonic anhydrase 20112
Carbonic anhydrase 30102
Carbonic anhydrase 60304
Carbonic anhydrase 5A, mitochondrial0101
Carbonic anhydrase 5A, mitochondrial0204
Carbonic anhydrase 70102
Carbonic anhydrase0102
Disintegrin and metalloproteinase domain-containing protein 171001
Carbonic anhydrase 0101
Beta-carbonic anhydrase 10101
Carbonic anhydrase 20101
Carbonic anhydrase, alpha family 0101
Carbonic anhydrase 0102
Carbonic anhydrase0102
Carbonic anhydrase0102
Carbonic anhydrase 0101
Delta carbonic anhydrase0101
Carbonic anhydrase 0102
Carbonic anhydrase 130101
Carbonic anhydrase 40101
Carbonic anhydrase 130102
Protein argonaute-20011
Carbonic anhydrase 140102
Carbonic anhydrase 5B, mitochondrial0103
90-kda heat shock protein beta HSP90 beta, partial0101
estrogen receptor beta isoform 10101
heat shock protein HSP 90-alpha isoform 20101
tyrosine-protein phosphatase non-receptor type 7 isoform 20101
Dihydroxyacetone phosphate acyltransferase0001
30S ribosomal protein S60101
30S ribosomal protein S70101
50S ribosomal protein L150101
Tetracycline resistance protein, class B0001
72 kDa type IV collagenase0101
Stromelysin-10202
50S ribosomal protein L100101
50S ribosomal protein L110101
50S ribosomal protein L7/L120101
50S ribosomal protein L190101
50S ribosomal protein L10101
50S ribosomal protein L200101
50S ribosomal protein L270101
50S ribosomal protein L280101
50S ribosomal protein L290101
50S ribosomal protein L310101
50S ribosomal protein L31 type B0101
50S ribosomal protein L320101
50S ribosomal protein L330101
50S ribosomal protein L340101
50S ribosomal protein L350101
50S ribosomal protein L360101
30S ribosomal protein S100101
30S ribosomal protein S110101
30S ribosomal protein S120101
30S ribosomal protein S130101
30S ribosomal protein S160101
30S ribosomal protein S180101
30S ribosomal protein S190101
30S ribosomal protein S200101
30S ribosomal protein S20101
30S ribosomal protein S30101
30S ribosomal protein S40101
30S ribosomal protein S50101
30S ribosomal protein S80101
30S ribosomal protein S90101
50S ribosomal protein L130101
50S ribosomal protein L140101
50S ribosomal protein L160101
50S ribosomal protein L230101
30S ribosomal protein S150101
Multidrug transporter MdfA0101
50S ribosomal protein L170101
50S ribosomal protein L210101
50S ribosomal protein L300101
50S ribosomal protein L60101
30S ribosomal protein S140101
30S ribosomal protein S170101
30S ribosomal protein S10101
50S ribosomal protein L180101
Neutrophil collagenase0101
Alpha-synuclein0101
Collagenase 30101
Cannabinoid receptor 10101
50S ribosomal protein L20101
50S ribosomal protein L30101
50S ribosomal protein L240101
50S ribosomal protein L40101
50S ribosomal protein L220101
50S ribosomal protein L50101
30S ribosomal protein S210101
50S ribosomal protein L250101
50S ribosomal protein L36 20101
Integrase 0101
Chain A, ykoF0011
Chain B, ykoF0011
Chain A, ThiT0011
Thiamine transporter ThiT0011
Transketolase0011
Thiamine-binding periplasmic protein0011
Chain A, Trp Rna-binding Attenuation Protein0011
Chain K, Trp Rna-binding Attenuation Protein0011
Chain B, tryptophanyl-tRNA synthetase0011
Chain C, Tryptophanyl-tRNA synthetase II0011
Dihydrofolate reductase0202
Plasma kallikrein0001
Myeloperoxidase0101
Alkaline phosphatase, tissue-nonspecific isozyme0101
Intestinal-type alkaline phosphatase0101
Indoleamine 2,3-dioxygenase 10102
Tryptophan 2,3-dioxygenase0102
Large neutral amino acids transporter small subunit 10101
SLC16A10 protein0001
Carbonic anhydrase-like protein, putative0001
Tryprostatin B synthase0001
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase0011
Monocarboxylate transporter 100001
Phospholipase A-2-activating protein0101
Cocaine esterase0101
Cytochrome P450 2A60101
Tissue factor0101
Aldo-keto reductase family 1 member A10101
Aldo-keto reductase family 1 member A10101
Aldo-keto reductase family 1 member A10101
Aldo-keto reductase family 1 member B70101
Sigma non-opioid intracellular receptor 10101
NAD-dependent protein deacylase sirtuin-5, mitochondrial0101
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]