Page last updated: 2024-11-05

4-aminophenylarsenoxide

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

4-aminophenylarsenoxide: RN given refers to parent cpd [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID14290
CHEMBL ID3290759
SCHEMBL ID246340
SCHEMBL ID157768
MeSH IDM0101772

Synonyms (29)

Synonym
3-16-00-00986 (beilstein handbook reference)
unii-q80f4ijc71
q80f4ijc71 ,
brn 2827922
nsc 10876
benzenamine, 4-arsenoso-
wln: zr d-as-o
4-arsenosobenzenamine
aniline, p-arsenoso-
p-arsenosoaniline
nsc-10876
nsc10876
1122-90-3
4-arsorosoaniline
4-aminophenylarsenoxide
FT-0662002
benzenamine,4-arsenoso-
(p-aminophenyl)arsenoxide
p-aminophenyl arsenoxide
p-aminophenylarsine oxide
(4-aminophenyl)arsine oxide
SCHEMBL246340
CHEMBL3290759
AKOS025293872
SCHEMBL157768
p-aminophenylarsinoxyd
DTXSID70149955
J-002744
Q27287091
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (3)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Thioredoxin reductase 1, cytoplasmicHomo sapiens (human)IC50 (µMol)4.00000.04322.26555.0000AID1154308
Thioredoxin reductase 3Homo sapiens (human)IC50 (µMol)4.00000.35003.11675.0000AID1154308
Thioredoxin reductase 2, mitochondrialHomo sapiens (human)IC50 (µMol)4.00000.35003.11675.0000AID1154308
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (11)

Processvia Protein(s)Taxonomy
mesoderm formationThioredoxin reductase 1, cytoplasmicHomo sapiens (human)
signal transductionThioredoxin reductase 1, cytoplasmicHomo sapiens (human)
cell population proliferationThioredoxin reductase 1, cytoplasmicHomo sapiens (human)
cellular oxidant detoxificationThioredoxin reductase 1, cytoplasmicHomo sapiens (human)
cell redox homeostasisThioredoxin reductase 1, cytoplasmicHomo sapiens (human)
spermatogenesisThioredoxin reductase 3Homo sapiens (human)
cell differentiationThioredoxin reductase 3Homo sapiens (human)
cell redox homeostasisThioredoxin reductase 3Homo sapiens (human)
cellular oxidant detoxificationThioredoxin reductase 3Homo sapiens (human)
response to oxygen radicalThioredoxin reductase 2, mitochondrialHomo sapiens (human)
response to xenobiotic stimulusThioredoxin reductase 2, mitochondrialHomo sapiens (human)
response to selenium ionThioredoxin reductase 2, mitochondrialHomo sapiens (human)
cell redox homeostasisThioredoxin reductase 2, mitochondrialHomo sapiens (human)
response to hyperoxiaThioredoxin reductase 2, mitochondrialHomo sapiens (human)
cellular oxidant detoxificationThioredoxin reductase 2, mitochondrialHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (8)

Processvia Protein(s)Taxonomy
thioredoxin-disulfide reductase (NADPH) activityThioredoxin reductase 1, cytoplasmicHomo sapiens (human)
protein bindingThioredoxin reductase 1, cytoplasmicHomo sapiens (human)
identical protein bindingThioredoxin reductase 1, cytoplasmicHomo sapiens (human)
NADPH peroxidase activityThioredoxin reductase 1, cytoplasmicHomo sapiens (human)
FAD bindingThioredoxin reductase 1, cytoplasmicHomo sapiens (human)
thioredoxin-disulfide reductase (NADPH) activityThioredoxin reductase 3Homo sapiens (human)
flavin adenine dinucleotide bindingThioredoxin reductase 3Homo sapiens (human)
thioredoxin-disulfide reductase (NADPH) activityThioredoxin reductase 2, mitochondrialHomo sapiens (human)
protein bindingThioredoxin reductase 2, mitochondrialHomo sapiens (human)
protein homodimerization activityThioredoxin reductase 2, mitochondrialHomo sapiens (human)
protein-containing complex bindingThioredoxin reductase 2, mitochondrialHomo sapiens (human)
flavin adenine dinucleotide bindingThioredoxin reductase 2, mitochondrialHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (11)

Processvia Protein(s)Taxonomy
fibrillar centerThioredoxin reductase 1, cytoplasmicHomo sapiens (human)
nucleoplasmThioredoxin reductase 1, cytoplasmicHomo sapiens (human)
cytosolThioredoxin reductase 1, cytoplasmicHomo sapiens (human)
extracellular exosomeThioredoxin reductase 1, cytoplasmicHomo sapiens (human)
mitochondrionThioredoxin reductase 1, cytoplasmicHomo sapiens (human)
cytosolThioredoxin reductase 1, cytoplasmicHomo sapiens (human)
cytoplasmThioredoxin reductase 1, cytoplasmicHomo sapiens (human)
nucleoplasmThioredoxin reductase 3Homo sapiens (human)
endoplasmic reticulumThioredoxin reductase 3Homo sapiens (human)
cytosolThioredoxin reductase 3Homo sapiens (human)
mitochondrionThioredoxin reductase 3Homo sapiens (human)
cytoplasmThioredoxin reductase 3Homo sapiens (human)
cytosolThioredoxin reductase 3Homo sapiens (human)
mitochondrionThioredoxin reductase 2, mitochondrialHomo sapiens (human)
mitochondrial matrixThioredoxin reductase 2, mitochondrialHomo sapiens (human)
cytosolThioredoxin reductase 2, mitochondrialHomo sapiens (human)
axonThioredoxin reductase 2, mitochondrialHomo sapiens (human)
dendriteThioredoxin reductase 2, mitochondrialHomo sapiens (human)
neuronal cell bodyThioredoxin reductase 2, mitochondrialHomo sapiens (human)
cytoplasmThioredoxin reductase 2, mitochondrialHomo sapiens (human)
mitochondrionThioredoxin reductase 2, mitochondrialHomo sapiens (human)
cytosolThioredoxin reductase 2, mitochondrialHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (6)

Assay IDTitleYearJournalArticle
AID1154295Cytotoxicity against human HL60 cells assessed as inhibition of proliferation after 72 hrs by MTT assay2014Journal of medicinal chemistry, Jun-26, Volume: 57, Issue:12
Dithiaarsanes induce oxidative stress-mediated apoptosis in HL-60 cells by selectively targeting thioredoxin reductase.
AID1154297Cytotoxicity against human HeLa cells assessed as inhibition of proliferation after 48 hrs by MTT assay2014Journal of medicinal chemistry, Jun-26, Volume: 57, Issue:12
Dithiaarsanes induce oxidative stress-mediated apoptosis in HL-60 cells by selectively targeting thioredoxin reductase.
AID1154298Cytotoxicity against human HepG2 cells assessed as inhibition of proliferation after 48 hrs by MTT assay2014Journal of medicinal chemistry, Jun-26, Volume: 57, Issue:12
Dithiaarsanes induce oxidative stress-mediated apoptosis in HL-60 cells by selectively targeting thioredoxin reductase.
AID1154296Cytotoxicity against human SSMC-7721 cells assessed as inhibition of proliferation after 48 hrs by MTT assay2014Journal of medicinal chemistry, Jun-26, Volume: 57, Issue:12
Dithiaarsanes induce oxidative stress-mediated apoptosis in HL-60 cells by selectively targeting thioredoxin reductase.
AID1154294Cytotoxicity against human HL60 cells assessed as inhibition of proliferation after 48 hrs by MTT assay2014Journal of medicinal chemistry, Jun-26, Volume: 57, Issue:12
Dithiaarsanes induce oxidative stress-mediated apoptosis in HL-60 cells by selectively targeting thioredoxin reductase.
AID1154308Inhibition of human TrxR activity in human HeLa cell lysate after 12 hrs by insulin reduction assay2014Journal of medicinal chemistry, Jun-26, Volume: 57, Issue:12
Dithiaarsanes induce oxidative stress-mediated apoptosis in HL-60 cells by selectively targeting thioredoxin reductase.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (10)

TimeframeStudies, This Drug (%)All Drugs %
pre-19903 (30.00)18.7374
1990's2 (20.00)18.2507
2000's1 (10.00)29.6817
2010's4 (40.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.18

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.18 (24.57)
Research Supply Index2.40 (2.92)
Research Growth Index4.58 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.18)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other10 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]