Acrodynia

A condition seen primarily in childhood, most often resulting from chronic exposure to MERCURY COMPOUNDS which may result in encephalopathy and POLYNEUROPATHY. Clinical features include pain, swelling and pinkish discoloration of the fingers and toes, weakness in the extremities, extreme irritability, HYPERESTHESIA, and alterations in level of consciousness. (From Menkes, Textbook of Child Neurology, 5th ed, p603)

Synonym
Acrodynic Erythema
Swift Disease
Swift's Disease
Feer Disease
Chronic Childhood Mercurialism
Acrodynia
Pink Disease
Feer's Disease

Excerpt	Reference
"Once acrodynia is identified as a primary symptom, a 24-hour urine mercury level can confirm the diagnosis."	( Alverson, BK; Brannan, EH; Su, S, 2012)

Excerpt	Reference
"Pink disease has virtually disappeared since teething powders were withdrawn."	( Curtis, HA; Ferguson, SD; Kell, RL; Samuel, AH, 1987)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	130 (87.84)	23.3326
1990's	9 (6.08)	12.5806
2000's	4 (2.70)	18.1394
2010's	5 (3.38)	28.8240
2020's	0 (0.00)	9.53

Drug	Relationship Strength	Studies
ammonium hydroxide	low	1
chlorine	low	4
hydrogen carbonate	low	1
iodine	low	1
methanol	low	1
niacin	low	2
pyridoxal phosphate	low	2
pyridoxine	low	7
thiamine	low	2
dimercaprol	low	25
isoniazid	low	1
apnea	low	1
nifedipine	low	1
phenobarbital	low	1
thalidomide	low	1
tolazoline	low	1
prednisolone	low	1
reserpine	low	3
penicillamine	low	8
prednisone	low	1
androsterone	low	1
chloramphenicol	low	2
sucrose	low	1
edetic acid	low	1
4-deoxypyridoxine	low	1
phenylalanine	low	1
desoxycorticosterone	low	1
cycloserine	low	1
dichloroacetic acid	low	1
mercury	medium	92
mercuric chloride	low	5
phenyl acetate	low	1
4-methoxyamphetamine	low	2
fomesafen	low	1
2-imidazoline	low	1
fibrinogen	low	1
cortisone	low	4
inositol 1,4,5-trisphosphate	low	1
riboflavin	low	1
succimer	low	2
ethionamide	low	1
zinc oxide	low	1
mercuric chloride, ammoniated	low	1
17-ketosteroids	low	2
thallium	low	1
arsenic	low	1
sulfur	low	2
selenium	low	1
thimerosal	low	2
cardiovascular agents	low	1
bellergal	low	1
cyclosporine	low	1
eye	low	1

Protein Targets (572)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
5-hydroxytryptamine receptor 2C	0	1	1	2
5-hydroxytryptamine receptor 2A	0	3	1	4
5-hydroxytryptamine receptor 1A	0	1	1	2
5-hydroxytryptamine receptor 1B	0	1	1	2
5-hydroxytryptamine receptor 1D	0	1	1	2
5-hydroxytryptamine receptor 1F	0	1	1	2
5-hydroxytryptamine receptor 2B	0	1	1	2
5-hydroxytryptamine receptor 6	0	0	1	1
Sodium-dependent serotonin transporter	0	0	1	1
Sodium-dependent serotonin transporter	0	1	0	1
5-hydroxytryptamine receptor 7	0	0	1	1
5-hydroxytryptamine receptor 5A	0	0	1	1
5-hydroxytryptamine receptor 5B	0	0	1	1
5-hydroxytryptamine receptor 3A	0	0	1	1
5-hydroxytryptamine receptor 4	0	0	1	1
5-hydroxytryptamine receptor 3B	0	0	1	1
Chain A, retinol dehydratase	0	1	0	1
acetylcholinesterase	6	0	0	6
RAR-related orphan receptor gamma	14	0	0	14
TDP1 protein	13	0	0	13
GLI family zinc finger 3	14	0	0	14
AR protein	20	0	0	20
estrogen receptor 2 (ER beta)	5	0	0	5
progesterone receptor	11	0	0	11
retinoic acid nuclear receptor alpha variant 1	16	0	0	16
retinoid X nuclear receptor alpha	11	0	0	11
estrogen-related nuclear receptor alpha	17	0	0	17
pregnane X nuclear receptor	14	0	0	14
estrogen nuclear receptor alpha	23	0	0	23
v-jun sarcoma virus 17 oncogene homolog (avian)	12	0	0	12
histone acetyltransferase KAT2A isoform 1	6	0	0	6
Gamma-aminobutyric acid receptor subunit pi	7	1	0	8
Voltage-dependent calcium channel gamma-2 subunit	8	0	0	8
Sex hormone-binding globulin	0	0	3	3
Corticosteroid-binding globulin	0	4	0	4
Glucose-6-phosphate 1-dehydrogenase	0	1	0	1
Androgen receptor	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-1	7	1	0	8
Gamma-aminobutyric acid receptor subunit delta	7	1	0	8
Gamma-aminobutyric acid receptor subunit gamma-2	7	1	0	8
Glutamate receptor 2	8	0	0	8
Gamma-aminobutyric acid receptor subunit alpha-5	7	1	0	8
Gamma-aminobutyric acid receptor subunit alpha-3	7	1	0	8
Gamma-aminobutyric acid receptor subunit gamma-1	7	1	0	8
Gamma-aminobutyric acid receptor subunit alpha-2	7	1	0	8
Gamma-aminobutyric acid receptor subunit alpha-4	7	1	0	8
Gamma-aminobutyric acid receptor subunit gamma-3	7	1	0	8
Gamma-aminobutyric acid receptor subunit alpha-6	7	1	0	8
Solute carrier organic anion transporter family member 1A1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	7	1	0	8
Gamma-aminobutyric acid receptor subunit beta-3	7	1	0	8
Gamma-aminobutyric acid receptor subunit beta-2	7	1	0	8
TAR DNA-binding protein 43	4	0	0	4
G-protein coupled bile acid receptor 1	0	0	1	1
GABA theta subunit	7	1	0	8
Gamma-aminobutyric acid receptor subunit epsilon	7	1	0	8
thioredoxin reductase	6	0	0	6
ATAD5 protein, partial	3	0	0	3
Microtubule-associated protein tau	7	0	0	7
arylsulfatase A	2	0	0	2
euchromatic histone-lysine N-methyltransferase 2	13	0	0	13
Bloom syndrome protein isoform 1	5	0	0	5
D(1A) dopamine receptor	2	0	0	2
lamin isoform A-delta10	8	0	0	8
neuropeptide S receptor isoform A	2	0	0	2
Chain A, Hyaluronidase, phage associated	0	1	0	1
thioredoxin glutathione reductase	3	0	0	3
cytochrome P450 family 3 subfamily A polypeptide 4	13	0	0	13
glucocorticoid receptor [Homo sapiens]	16	0	0	16
vitamin D (1,25- dihydroxyvitamin D3) receptor	11	0	0	11
IDH1	5	0	0	5
chromobox protein homolog 1	7	0	0	7
nuclear factor erythroid 2-related factor 2 isoform 2	7	0	0	7
thyroid hormone receptor beta isoform 2	12	0	0	12
nuclear factor erythroid 2-related factor 2 isoform 1	17	0	0	17
lethal(3)malignant brain tumor-like protein 1 isoform I	2	0	0	2
geminin	12	0	0	12
lethal factor (plasmid)	5	0	0	5
Polyphenol oxidase 2	0	4	0	5
Pancreatic alpha-amylase	0	2	0	2
Albumin	0	1	0	1
Urease	0	1	0	1
Prolyl 4-hydroxylase subunit alpha-1	0	0	0	1
Tyrosinase	0	1	0	1
Alpha-2B adrenergic receptor	0	0	1	1
Spike glycoprotein	3	0	0	3
Hyaluronate lyase	0	1	0	1
Prolyl hydroxylase EGLN2	0	0	0	1
Egl nine homolog 1	0	0	0	1
Prolyl hydroxylase EGLN3	0	0	0	1
Hypoxia-inducible factor 1-alpha inhibitor	0	0	0	1
Solute carrier family 23 member 1	0	1	0	1
interleukin 8	2	0	0	2
aldehyde dehydrogenase 1 family, member A1	13	0	0	13
EWS/FLI fusion protein	4	0	0	4
farnesoid X nuclear receptor	7	0	0	7
G	5	0	0	5
cytochrome P450 2D6	8	0	0	8
peroxisome proliferator activated receptor gamma	10	0	0	10
aryl hydrocarbon receptor	10	0	0	10
activating transcription factor 6	8	0	0	8
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	9	0	0	9
heat shock protein beta-1	5	0	0	5
DNA polymerase iota isoform a (long)	5	0	0	5
streptokinase A precursor	0	0	1	1
Dihydroxyacetone phosphate acyltransferase	0	0	0	1
ATP-binding cassette sub-family C member 3	0	5	0	5
Multidrug resistance-associated protein 4	0	5	0	5
Bile salt export pump	0	14	0	14
Interferon beta	7	0	0	7
HLA class I histocompatibility antigen, B alpha chain	5	0	0	5
30S ribosomal protein S6	0	1	0	1
30S ribosomal protein S7	0	1	0	1
50S ribosomal protein L15	0	1	0	1
Cellular tumor antigen p53	10	0	0	10
Cytochrome P450 3A4	0	3	0	3
50S ribosomal protein L10	0	1	0	1
50S ribosomal protein L11	0	1	0	1
50S ribosomal protein L7/L12	0	1	0	1
50S ribosomal protein L19	0	1	0	1
50S ribosomal protein L1	0	1	0	1
50S ribosomal protein L20	0	1	0	1
50S ribosomal protein L27	0	1	0	1
50S ribosomal protein L28	0	1	0	1
50S ribosomal protein L29	0	1	0	1
50S ribosomal protein L31	0	1	0	1
50S ribosomal protein L31 type B	0	1	0	1
50S ribosomal protein L32	0	1	0	1
50S ribosomal protein L33	0	1	0	1
50S ribosomal protein L34	0	1	0	1
50S ribosomal protein L35	0	1	0	1
50S ribosomal protein L36	0	1	0	1
30S ribosomal protein S10	0	1	0	1
30S ribosomal protein S11	0	1	0	1
30S ribosomal protein S12	0	1	0	1
30S ribosomal protein S13	0	1	0	1
30S ribosomal protein S16	0	1	0	1
30S ribosomal protein S18	0	1	0	1
30S ribosomal protein S19	0	1	0	1
30S ribosomal protein S20	0	1	0	1
30S ribosomal protein S2	0	1	0	1
30S ribosomal protein S3	0	1	0	1
30S ribosomal protein S4	0	1	0	1
30S ribosomal protein S5	0	1	0	1
30S ribosomal protein S8	0	1	0	1
30S ribosomal protein S9	0	1	0	1
50S ribosomal protein L13	0	1	0	1
50S ribosomal protein L14	0	1	0	1
50S ribosomal protein L16	0	1	0	1
50S ribosomal protein L23	0	1	0	1
30S ribosomal protein S15	0	1	0	1
50S ribosomal protein L17	0	1	0	1
50S ribosomal protein L21	0	1	0	1
50S ribosomal protein L30	0	1	0	1
50S ribosomal protein L6	0	1	0	1
30S ribosomal protein S14	0	1	0	1
30S ribosomal protein S17	0	1	0	1
30S ribosomal protein S1	0	1	0	1
50S ribosomal protein L18	0	1	0	1
50S ribosomal protein L2	0	1	0	1
50S ribosomal protein L3	0	1	0	1
50S ribosomal protein L24	0	1	0	1
50S ribosomal protein L4	0	1	0	1
50S ribosomal protein L22	0	1	0	1
50S ribosomal protein L5	0	1	0	1
30S ribosomal protein S21	0	1	0	1
50S ribosomal protein L25	0	1	0	1
50S ribosomal protein L36 2	0	1	0	1
Inositol hexakisphosphate kinase 1	5	0	0	5
Methionine--tRNA ligase, mitochondrial	0	0	1	1
cytochrome P450 2C9, partial	5	0	0	5
Carbonic anhydrase 1	0	3	0	4
Carbonic anhydrase 2	0	4	1	6
Carbonic anhydrase 4	0	2	0	3
Carbonic anhydrase	0	2	0	3
Carbonic anhydrase 15	0	2	0	3
Chain A, HADH2 protein	8	0	0	8
Chain B, HADH2 protein	8	0	0	8
endonuclease IV	2	0	0	2
dopamine D1 receptor	1	0	0	1
pregnane X receptor	4	0	0	4
GLS protein	6	0	0	6
regulator of G-protein signaling 4	6	0	0	6
peroxisome proliferator-activated receptor delta	8	0	0	8
peripheral myelin protein 22 isoform 1	3	0	0	3
atrial natriuretic peptide receptor 1 precursor	1	0	0	1
flap endonuclease 1	4	0	0	4
survival motor neuron protein isoform d	5	0	0	5
cytochrome P450 3A4 isoform 1	7	0	0	7
M-phase phosphoprotein 8	4	0	0	4
muscarinic acetylcholine receptor M1	4	0	0	4
Glucocorticoid receptor	0	6	2	13
Glycine receptor subunit alpha-1	0	6	0	6
Glycine receptor subunit beta	0	6	0	6
Glycine receptor subunit alpha-2	0	6	0	6
Glycine receptor subunit alpha-3	0	6	0	6
Potassium voltage-gated channel subfamily A member 1	0	1	1	2
Multidrug and toxin extrusion protein 1	0	2	0	2
Chain A, N-methyl-D-aspartate Receptor Subunit 1	0	1	0	1
Chain A, N-methyl-D-aspartate Receptor Subunit 1	0	1	0	1
Chain A, N-methyl-D-aspartate Receptor Subunit 1	0	1	0	1
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	4	0	0	4
thyroid stimulating hormone receptor	5	0	0	5
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	9	0	0	9
cytochrome P450 2C9 precursor	2	0	0	2
mitogen-activated protein kinase 1	6	0	0	6
Bile salt export pump	0	5	0	5
Glutamate receptor ionotropic, NMDA 1	0	1	1	3
Histamine H2 receptor	4	0	0	4
Glutamate receptor ionotropic, NMDA 2A	0	1	1	3
Glutamate receptor ionotropic, NMDA 2B	0	1	1	3
Glutamate receptor ionotropic, NMDA 2C	0	1	1	3
D-alanine--D-alanine ligase	0	1	0	1
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase	0	1	0	1
Glutamate receptor ionotropic, NMDA 2D	0	1	1	3
Proton-coupled amino acid transporter 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	1	1	3
Glutamate receptor ionotropic, NMDA 3A	0	1	1	3
ATP-dependent phosphofructokinase	5	0	0	5
phosphopantetheinyl transferase	6	0	0	6
SMAD family member 2	4	0	0	4
USP1 protein, partial	5	0	0	5
GALC protein	1	0	0	1
SMAD family member 3	4	0	0	4
nuclear receptor subfamily 1, group I, member 3	8	0	0	8
nuclear receptor subfamily 1, group I, member 2	3	0	0	3
urokinase-type plasminogen activator precursor	3	0	0	3
plasminogen precursor	3	0	0	3
urokinase plasminogen activator surface receptor precursor	3	0	0	3
nuclear receptor ROR-gamma isoform 1	5	0	0	5
Solute carrier family 22 member 3	0	1	0	1
Solute carrier family 22 member 2	0	2	0	2
thyroid hormone receptor beta isoform a	7	0	0	7
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial	0	1	0	1
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial	0	1	0	1
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial	0	1	0	1
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial	0	1	0	1
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
ATPase family AAA domain-containing protein 5	5	0	0	5
Ataxin-2	5	0	0	5
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	6	0	0	6
hypoxia-inducible factor 1 alpha subunit	7	0	0	7
Histone H2A.x	4	0	0	4
Eyes absent homolog 2	0	1	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15B	3	0	0	3
Amyloid-beta precursor protein	0	2	0	2
Angiotensin-converting enzyme	0	1	0	1
Metallo-beta-lactamase VIM-13	0	1	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase VIM-1	0	1	0	1
Smad3	3	0	0	3
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	2	0	0	2
DNA polymerase beta	3	0	0	3
Nuclear receptor ROR-gamma	4	0	0	4
Luciferase	6	0	0	6
Chain A, BETA-SPECTRIN	0	0	1	1
Chain A, Phospholipase C Delta-1	0	0	1	1
Chain A, Inositol 1,4,5-trisphosphate receptor type 1	0	0	1	1
Inositol-trisphosphate 3-kinase A	0	1	0	1
Inositol 1,4,5-trisphosphate receptor type 1	0	0	2	2
Inositol 1,4,5-trisphosphate receptor type 2	0	1	0	1
Inositol 1,4,5-trisphosphate receptor type 3	0	1	1	2
Inositol polyphosphate-5-phosphatase A	0	1	0	1
Inositol 1,4,5-trisphosphate receptor type 1	0	1	1	2
histone deacetylase 9 isoform 3	2	0	0	2
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	7	0	0	7
Chain A, 2-oxoglutarate Oxygenase	5	0	0	5
67.9K protein	3	0	0	3
bromodomain adjacent to zinc finger domain 2B	5	0	0	5
3-oxoacyl-[acyl-carrier-protein] synthase 3	0	1	0	1
cytochrome P450 2D6 isoform 1	3	0	0	3
potassium voltage-gated channel subfamily H member 2 isoform d	2	0	0	2
N-glycosylase/DNA lyase	0	1	0	1
Myeloperoxidase	0	1	0	1
Cytochrome P450 1A2	0	2	0	2
Formamidopyrimidine-DNA glycosylase	0	1	0	1
DNA gyrase subunit A	0	1	0	1
DNA gyrase subunit B	0	1	0	1
Cytochrome P450 2C8	0	1	0	1
Cytochrome P450 2A6	0	1	0	1
Macrophage migration inhibitory factor	0	1	0	1
Cytochrome P450 2C19	0	1	0	1
Endonuclease III-like protein 1	0	1	0	1
DNA gyrase subunit B	0	1	0	1
DNA gyrase subunit A	0	1	0	1
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	1	0	2
Pantothenate synthetase	0	1	0	1
Isocitrate lyase	0	1	0	1
Putative FAD-containing monooxygenase MymA	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Canalicular multispecific organic anion transporter 1	0	5	0	5
Endonuclease 8-like 1	0	1	0	1
Chain A, JmjC domain-containing histone demethylation protein 3A	5	0	0	5
glp-1 receptor, partial	3	0	0	3
thyrotropin-releasing hormone receptor	3	0	0	3
lysosomal alpha-glucosidase preproprotein	2	0	0	2
Neuronal acetylcholine receptor subunit alpha-4	2	0	0	2
Cholesteryl ester transfer protein	0	1	0	1
Cytochrome P450 2C9	0	3	1	4
Neuronal acetylcholine receptor subunit beta-2	2	0	0	2
D-amino-acid oxidase	0	1	0	1
Xanthine dehydrogenase/oxidase	0	1	0	1
Hydroxycarboxylic acid receptor 3	0	0	1	1
Nicotinamidase	0	1	0	1
Hydroxycarboxylic acid receptor 2	0	0	1	1
Hydroxycarboxylic acid receptor 2	0	2	1	3
D-aspartate oxidase	0	1	0	1
Hydroxycarboxylic acid receptor 2	0	1	1	2
Chain A, NAD-dependent deacetylase	0	1	0	1
Caspase-7	1	0	0	1
caspase-3	1	0	0	1
Poly [ADP-ribose] polymerase 2	0	1	0	1
NAD-dependent histone deacetylase SIR2	0	1	0	1
Coagulation factor VII	0	1	0	1
Poly [ADP-ribose] polymerase 1	0	1	0	1
Tissue factor	0	1	0	1
Cytochrome P450 3A5	0	1	0	1
NAD-dependent protein deacetylase HST2	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
Protein mono-ADP-ribosyltransferase PARP15	0	1	0	1
NAD(+) hydrolase SARM1	0	1	0	1
NAD-dependent protein deacetylase sirtuin-2	0	1	0	1
NAD-dependent protein deacetylase sirtuin-6	0	1	0	1
NAD-dependent protein deacetylase sirtuin-1	0	1	0	1
NAD-dependent protein deacetylase sirtuin-3, mitochondrial	0	1	0	1
NAD-dependent protein deacylase sirtuin-5, mitochondrial	0	1	0	1
NAD-dependent protein deacetylase	0	1	0	1
Chain A, Beta-lactamase	3	0	0	3
Chain A, Putative fructose-1,6-bisphosphate aldolase	4	0	0	4
Fumarate hydratase	2	0	0	2
NFKB1 protein, partial	1	0	0	1
Thrombopoietin	2	0	0	2
hypothetical protein, conserved	2	0	0	2
nonstructural protein 1	2	0	0	2
polyprotein	2	0	0	2
Parkin	1	0	0	1
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	1	0	0	1
thyroid stimulating hormone receptor	5	0	0	5
beta-2 adrenergic receptor	1	0	0	1
cellular tumor antigen p53 isoform a	2	0	0	2
tumor necrosis factor	2	0	0	2
polyunsaturated fatty acid lipoxygenase ALOX12	2	0	0	2
cytochrome P450 2C19 precursor	1	0	0	1
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	5	0	0	5
perilipin-5	0	1	0	1
vitamin D3 receptor isoform VDRA	6	0	0	6
perilipin-1	0	1	0	1
atrial natriuretic peptide receptor 2 precursor	1	0	0	1
serine/threonine-protein kinase mTOR isoform 1	1	0	0	1
serine/threonine-protein kinase PLK1	3	0	0	3
eyes absent homolog 2 isoform a	1	0	0	1
histone-lysine N-methyltransferase 2A isoform 2 precursor	2	0	0	2
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a	0	1	0	1
peripheral myelin protein 22	8	0	0	8
muscleblind-like protein 1 isoform 1	3	0	0	3
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1F	0	2	0	2
5-hydroxytryptamine receptor 4	0	2	0	2
Potassium channel subfamily K member 2	0	0	1	1
Glutathione reductase, mitochondrial	0	2	0	2
Integrin beta-3	2	0	0	2
Muscarinic acetylcholine receptor M2	0	0	0	1
Muscarinic acetylcholine receptor M4	0	0	0	1
ATP-dependent translocase ABCB1	0	3	0	3
Integrin alpha-IIb	2	0	0	2
Muscarinic acetylcholine receptor M5	0	0	0	1
Adenosine receptor A3	0	2	0	2
Muscarinic acetylcholine receptor M1	0	0	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15	0	1	0	1
Phospholipase A2, membrane associated	0	0	0	1
Alpha-1B adrenergic receptor	0	3	1	4
Muscarinic acetylcholine receptor M3	0	0	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	2	0	2
Potassium voltage-gated channel subfamily A member 5	0	1	0	1
3-oxo-5-alpha-steroid 4-dehydrogenase 1	0	1	0	1
Thromboxane-A synthase	0	1	0	1
Platelet-activating factor receptor	0	0	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	1	0	1
5-hydroxytryptamine receptor 2C	0	2	0	2
Indoleamine 2,3-dioxygenase 1	0	1	0	1
Adenosine receptor A2a	0	1	0	1
Adenosine receptor A1	0	2	0	2
Adenosine receptor A2a	0	1	0	2
3-oxo-5-alpha-steroid 4-dehydrogenase 2	0	1	0	1
Sodium channel protein type 1 subunit alpha	0	2	0	2
Sodium channel protein type 4 subunit alpha	0	1	0	1
C-C chemokine receptor type 2	0	2	0	2
Alpha-1A adrenergic receptor	0	3	1	4
Cytochrome P450 2J2	0	2	0	2
Inositol monophosphatase 1	2	0	0	2
Sodium channel protein type 7 subunit alpha	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	1	0	1
Potassium voltage-gated channel subfamily H member 2	0	2	0	2
C-terminal-binding protein 1	1	0	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1C	0	2	0	3
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	0	1	0	1
Sodium channel protein type 5 subunit alpha	0	1	0	1
Leukotriene B4 receptor 1	0	0	0	1
Myosin light chain kinase, smooth muscle	0	1	0	1
Sodium channel protein type 9 subunit alpha	0	1	0	1
Transient receptor potential cation channel subfamily A member 1	0	0	1	1
Potassium channel subfamily K member 2	0	1	0	1
Beta-2 adrenergic receptor	0	0	0	1
Indoleamine 2,3-dioxygenase 2	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1F	0	1	0	1
Leukotriene B4 receptor 2	0	0	0	1
Sodium channel protein type 3 subunit alpha	0	2	0	2
Sodium channel protein type 11 subunit alpha	0	1	0	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	2	0	2
Sodium channel protein type 8 subunit alpha	0	1	0	1
Sodium channel protein type 10 subunit alpha	0	1	0	1
Chain A, ATP-DEPENDENT DNA HELICASE Q1	2	0	0	2
WRN	1	0	0	1
Valosin-containing protein	0	1	0	1
apical membrane antigen 1, AMA1	2	0	0	2
transcriptional regulator ERG isoform 3	1	0	0	1
microphthalmia-associated transcription factor isoform 9	0	1	0	1
importin subunit beta-1 isoform 1	3	0	0	3
ubiquitin carboxyl-terminal hydrolase 2 isoform a	1	0	0	1
eukaryotic translation initiation factor 4 gamma 1 isoform 4	0	1	0	1
snurportin-1	3	0	0	3
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	2	0	0	2
DNA polymerase eta isoform 1	2	0	0	2
eukaryotic translation initiation factor 4E isoform 1	0	1	0	1
DNA polymerase kappa isoform 1	1	0	0	1
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	1	0	0	1
Rap guanine nucleotide exchange factor 3	1	0	0	1
Serum paraoxonase/arylesterase 1	0	1	0	1
phosphoglycerate kinase	1	0	0	1
Cystathionine gamma-lyase	0	1	0	1
Succinyl-diaminopimelate desuccinylase	0	1	0	1
Chain A, AMINOPEPTIDASE	0	1	0	1
Chain A, AMINOPEPTIDASE	0	1	0	1
Voltage-dependent calcium channel subunit alpha-2/delta-1	0	1	0	1
Carbonic anhydrase 12	0	0	0	1
Plasma kallikrein	0	0	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	1	0	1
Carbonic anhydrase 3	0	0	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	1	0	1
Intestinal-type alkaline phosphatase	0	1	0	1
Intestinal-type alkaline phosphatase	0	1	0	1
5'-nucleotidase	0	1	0	1
Carbonic anhydrase 6	0	1	0	2
Adenosine receptor A1	0	0	0	1
Carbonic anhydrase 5A, mitochondrial	0	0	0	1
Carbonic anhydrase 7	0	0	0	1
Carbonic anhydrase	0	0	0	1
E3 ubiquitin-protein ligase XIAP	0	1	0	1
Large neutral amino acids transporter small subunit 1	0	1	0	2
SLC16A10 protein	0	0	0	1
Carbonic anhydrase 9	0	1	1	3
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase-like protein, putative	0	0	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase	0	0	0	1
Large neutral amino acids transporter small subunit 1	0	1	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase 13	0	0	0	1
Monocarboxylate transporter 10	0	0	0	1
Carbonic anhydrase 13	0	0	0	1
Carbonic anhydrase 14	0	0	0	1
Phospholipase A-2-activating protein	0	1	0	1
Carbonic anhydrase 5B, mitochondrial	0	0	0	1
luciferase	0	0	0	1
Fatty acid-binding protein, liver	0	1	0	1
Estrogen receptor	0	2	0	2
Progesterone receptor	0	2	0	3
Glucocorticoid receptor	0	1	1	2
Glucocorticoid receptor	0	0	1	1
Mineralocorticoid receptor	0	2	1	3
Androgen receptor	0	2	0	2
Glutamine synthetase	0	0	1	1
Histamine H1 receptor	0	0	1	1
Prostaglandin G/H synthase 2	0	1	0	1
Nociceptin receptor	0	0	1	1
Estrogen receptor beta	0	2	0	2
Receptor-type tyrosine-protein phosphatase beta	0	0	0	1
Low molecular weight phosphotyrosine protein phosphatase	0	1	0	1
P2X purinoceptor 1	0	0	1	1
P2X purinoceptor 1	0	1	0	1
P2X purinoceptor 4	0	0	1	1
Trans-sialidase	0	1	0	1
Trans-sialidase	0	1	0	1
P2X purinoceptor 2	0	0	1	1
Pyridoxal kinase	0	0	0	1
15-lipoxygenase, partial	3	0	0	3
caspase 7, apoptosis-related cysteine protease	1	0	0	1
caspase-3	1	0	0	1
hemoglobin subunit beta	1	0	0	1
nuclear factor NF-kappa-B p105 subunit isoform 1	3	0	0	3
GTP-binding nuclear protein Ran isoform 1	2	0	0	2
caspase-1 isoform alpha precursor	2	0	0	2
DNA dC->dU-editing enzyme APOBEC-3F isoform a	1	0	0	1
ATP-dependent translocase ABCB1	0	1	0	1
Quinolone resistance protein NorA	0	1	0	2
DNA topoisomerase 1	0	1	0	1
ATP-dependent translocase ABCB1	0	1	0	1
5-hydroxytryptamine receptor 2A	0	1	0	1
Mu-type opioid receptor	0	2	0	2
Chromaffin granule amine transporter	0	1	0	1
Caspase-7	2	0	0	2
Synaptic vesicular amine transporter	0	1	0	1
Synaptic vesicular amine transporter	0	2	1	3
Synaptic vesicular amine transporter	0	1	0	1
Solute carrier family 22 member 1	0	2	0	2
Chain A, 6,7-Dimethyl-8-ribityllumazine Synthase	0	0	1	1
Chain B, 6,7-Dimethyl-8-ribityllumazine Synthase	0	0	1	1
Chain A, Breast cancer type 1 susceptibility protein	1	0	0	1
Chain H, Immunoglobulin Igg1 Heavy chain	0	0	1	1
Chain L, Immunoglobulin Igg1 Lambda Light Chain	0	0	1	1
Chain A, DODECIN	0	0	1	1
Chain A, DODECIN	0	0	1	1
Chain C, DODECIN	0	0	1	1
Chain E, DODECIN	0	0	1	1
NPYLR7B	0	0	1	1
Riboflavin-binding protein	0	1	1	2
60 kDa chaperonin	0	1	0	1
60 kDa heat shock protein, mitochondrial	0	1	0	1
10 kDa heat shock protein, mitochondrial	0	1	0	1
Thiosulfate sulfurtransferase	0	1	0	1
60 kDa chaperonin	0	1	0	1
10 kDa chaperonin	0	1	0	1
Replicase polyprotein 1ab	0	1	0	1
Replicase polyprotein 1ab	0	2	0	2
Chain A, MALTOPORIN	0	0	1	1
Chain B, MALTOPORIN	0	0	1	1
Cereblon isoform 4	0	2	0	2
Prostaglandin G/H synthase 1	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
DNA-binding protein Ikaros	0	0	0	1
DNA damage-binding protein 1	0	1	1	2
Protein cereblon	0	2	1	4
Chain A, ykoF	0	0	1	1
Chain B, ykoF	0	0	1	1
Chain A, ThiT	0	0	1	1
Thiamine transporter ThiT	0	0	1	1
Solute carrier family 22 member 1	0	1	0	2
Transketolase	0	0	1	1
Thiamine-binding periplasmic protein	0	0	1	1
Chain A, Cruzipain	1	0	0	1
Nrf2	1	0	0	1
Caspase 6, apoptosis-related cysteine peptidase	0	0	0	1
glucocerebrosidase	1	0	0	1
toll-like receptor 9	0	1	0	1
caspase recruitment domain family, member 15	0	1	0	1
huntingtin isoform 2	1	0	0	1
neurotensin receptor type 1	0	0	1	1
receptor-interacting serine/threonine-protein kinase 2 isoform 1	0	1	0	1
heat shock protein HSP 90-alpha isoform 2	0	0	0	1
Replicase polyprotein 1ab	0	1	0	1
Alpha-synuclein	1	0	0	1
heat shock protein 90, putative	0	0	0	1
large T antigen	0	1	0	1
Beta lactamase (plasmid)	0	1	0	1
Alpha-2B adrenergic receptor	0	1	1	2
Alpha-2C adrenergic receptor	0	1	1	2
Alpha-2A adrenergic receptor	0	1	1	2
Alpha-1D adrenergic receptor	0	1	1	2
5-hydroxytryptamine receptor 1D	0	1	0	1
5-hydroxytryptamine receptor 1B	0	1	0	1
Trace amine-associated receptor 1	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(8)

Research Excerpts

Overview

Context

Research

Studies (148)

Protein Targets (572)

Acrodynia

Synonyms(8)

Research Excerpts

Overview

Context

Research

Studies (148)

Drugs Studied (62)

Protein Targets (572)