| Assay ID | Title | Year | Journal | Article |
|---|
| AID699065 | Selectivity ratio of Ki for 5HT1A receptor to Ki for rat 5HT7R | 2012 | Journal of medicinal chemistry, Jul-26, Volume: 55, Issue:14
| Investigations on the 1-(2-biphenyl)piperazine motif: identification of new potent and selective ligands for the serotonin(7) (5-HT(7)) receptor with agonist or antagonist action in vitro or ex vivo. |
| AID1595155 | Effect on cAMP response in mouse N1E-115 cells at 10 uM by confocal laser scanning microscopy | | | |
| AID386653 | Elimination half life in CD1 albino mouse plasma at 10 mg/kg, po | 2008 | Journal of medicinal chemistry, Sep-25, Volume: 51, Issue:18
| Structural modifications of N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4-aryl-1-piperazinehexanamides: influence on lipophilicity and 5-HT7 receptor activity. Part III. |
| AID780758 | Binding affinity to sigma 1 receptor (unknown origin) by radioligand binding assay | 2013 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 23, Issue:22
| Novel highly potent serotonin 5-HT7 receptor ligands: structural modifications to improve pharmacokinetic properties. |
| AID391748 | Agonist activity at 5HT7 receptor assessed as relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction | 2008 | Journal of medicinal chemistry, Sep-25, Volume: 51, Issue:18
| Structural modifications of N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4-aryl-1-piperazinehexanamides: influence on lipophilicity and 5-HT7 receptor activity. Part III. |
| AID694795 | Displacement of [3H]-8-OH-DPAT from human 5-HT1A receptor expressed in HEK293 cells after 1 hr | 2012 | European journal of medicinal chemistry, Oct, Volume: 56 | The multiobjective based design, synthesis and evaluation of the arylsulfonamide/amide derivatives of aryloxyethyl- and arylthioethyl- piperidines and pyrrolidines as a novel class of potent 5-HT₇ receptor antagonists. |
| AID1318808 | Half life in mouse liver microsomes in presence of NADPH by liquid chromatographic method | 2016 | European journal of medicinal chemistry, Sep-14, Volume: 120 | Structural modifications of the serotonin 5-HT7 receptor agonist N-(4-cyanophenylmethyl)-4-(2-biphenyl)-1-piperazinehexanamide (LP-211) to improve in vitro microsomal stability: A case study. |
| AID391747 | Displacement of [3H]spiroperidol from human cloned dopamine D2L receptor expressed in rat C6 cells | 2008 | Journal of medicinal chemistry, Sep-25, Volume: 51, Issue:18
| Structural modifications of N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4-aryl-1-piperazinehexanamides: influence on lipophilicity and 5-HT7 receptor activity. Part III. |
| AID386663 | Selectivity for rat cloned 5HT7 over human cloned dopamine D2 | 2008 | Journal of medicinal chemistry, Sep-25, Volume: 51, Issue:18
| Structural modifications of N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4-aryl-1-piperazinehexanamides: influence on lipophilicity and 5-HT7 receptor activity. Part III. |
| AID780763 | Displacement of [3H]LSD from human 5HT7 receptor after 1.5 hrs | 2013 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 23, Issue:22
| Novel highly potent serotonin 5-HT7 receptor ligands: structural modifications to improve pharmacokinetic properties. |
| AID780757 | Binding affinity to sigma 2 receptor (unknown origin) by radioligand binding assay | 2013 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 23, Issue:22
| Novel highly potent serotonin 5-HT7 receptor ligands: structural modifications to improve pharmacokinetic properties. |
| AID1318804 | Displacement of [3H]-LSD from human 5-HT6 receptor after 1.5 hrs by cell based assay | 2016 | European journal of medicinal chemistry, Sep-14, Volume: 120 | Structural modifications of the serotonin 5-HT7 receptor agonist N-(4-cyanophenylmethyl)-4-(2-biphenyl)-1-piperazinehexanamide (LP-211) to improve in vitro microsomal stability: A case study. |
| AID386652 | Volume of distribution in CD1 albino mouse plasma at 10 mg/kg, po | 2008 | Journal of medicinal chemistry, Sep-25, Volume: 51, Issue:18
| Structural modifications of N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4-aryl-1-piperazinehexanamides: influence on lipophilicity and 5-HT7 receptor activity. Part III. |
| AID391749 | Agonist activity at 5HT7 receptor assessed as relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction relative to 5-carboxamidotryptamine | 2008 | Journal of medicinal chemistry, Sep-25, Volume: 51, Issue:18
| Structural modifications of N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4-aryl-1-piperazinehexanamides: influence on lipophilicity and 5-HT7 receptor activity. Part III. |
| AID1318812 | Agonist activity at 5-HT7 receptor in embryonic day 15 C57BL/6 mouse striatum assessed as increase in neurite length at 100 nM after 4 hrs by DAPI staining based microscopy | 2016 | European journal of medicinal chemistry, Sep-14, Volume: 120 | Structural modifications of the serotonin 5-HT7 receptor agonist N-(4-cyanophenylmethyl)-4-(2-biphenyl)-1-piperazinehexanamide (LP-211) to improve in vitro microsomal stability: A case study. |
| AID699063 | Selectivity ratio of Ki for D2 receptor to Ki for rat cloned 5HT7R | 2012 | Journal of medicinal chemistry, Jul-26, Volume: 55, Issue:14
| Investigations on the 1-(2-biphenyl)piperazine motif: identification of new potent and selective ligands for the serotonin(7) (5-HT(7)) receptor with agonist or antagonist action in vitro or ex vivo. |
| AID386658 | Elimination half life in CD1 albino mouse brain at 10 mg/kg, ip | 2008 | Journal of medicinal chemistry, Sep-25, Volume: 51, Issue:18
| Structural modifications of N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4-aryl-1-piperazinehexanamides: influence on lipophilicity and 5-HT7 receptor activity. Part III. |
| AID1318803 | Displacement of [3H]-8-OH-DPAT from human 5-HT1A receptor after 1.5 hrs by cell based assay | 2016 | European journal of medicinal chemistry, Sep-14, Volume: 120 | Structural modifications of the serotonin 5-HT7 receptor agonist N-(4-cyanophenylmethyl)-4-(2-biphenyl)-1-piperazinehexanamide (LP-211) to improve in vitro microsomal stability: A case study. |
| AID1318807 | Agonist activity at 5-HT7 receptor in embryonic day 15 C57BL/6 mouse cortex assessed as increase in neurite length at 100 nM after 30 mins by DAPI staining based microscopy | 2016 | European journal of medicinal chemistry, Sep-14, Volume: 120 | Structural modifications of the serotonin 5-HT7 receptor agonist N-(4-cyanophenylmethyl)-4-(2-biphenyl)-1-piperazinehexanamide (LP-211) to improve in vitro microsomal stability: A case study. |
| AID694794 | Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr | 2012 | European journal of medicinal chemistry, Oct, Volume: 56 | The multiobjective based design, synthesis and evaluation of the arylsulfonamide/amide derivatives of aryloxyethyl- and arylthioethyl- piperidines and pyrrolidines as a novel class of potent 5-HT₇ receptor antagonists. |
| AID1318809 | Intrinsic clearance in mouse plasma in presence of NADPH by liquid chromatographic method | 2016 | European journal of medicinal chemistry, Sep-14, Volume: 120 | Structural modifications of the serotonin 5-HT7 receptor agonist N-(4-cyanophenylmethyl)-4-(2-biphenyl)-1-piperazinehexanamide (LP-211) to improve in vitro microsomal stability: A case study. |
| AID1126168 | Displacement of [3H]-8-OH-DPAT from human 5-HT1A receptor expressed in HEK293 cells after 1 hr by beta-counting | 2014 | European journal of medicinal chemistry, May-06, Volume: 78 | Solid-supported synthesis, molecular modeling, and biological activity of long-chain arylpiperazine derivatives with cyclic amino acid amide fragments as 5-HT(7) and 5-HT(1A) receptor ligands. |
| AID1318811 | Agonist activity at 5-HT7 receptor in embryonic day 15 C57BL/6 mouse striatum assessed as increase in neurite length at 100 nM after 2 hrs by DAPI staining based microscopy relative to control | 2016 | European journal of medicinal chemistry, Sep-14, Volume: 120 | Structural modifications of the serotonin 5-HT7 receptor agonist N-(4-cyanophenylmethyl)-4-(2-biphenyl)-1-piperazinehexanamide (LP-211) to improve in vitro microsomal stability: A case study. |
| AID1067151 | Displacement of [3H]-prazosin from rat brain alpha1 adrenergic receptor after 50 mins | 2014 | Bioorganic & medicinal chemistry, Mar-01, Volume: 22, Issue:5
| Design, synthesis, radiolabeling and in vivo evaluation of potential positron emission tomography (PET) radioligands for brain imaging of the 5-HT₇ receptor. |
| AID1318805 | Binding affinity to dopamine D2 receptor (unknown origin) | 2016 | European journal of medicinal chemistry, Sep-14, Volume: 120 | Structural modifications of the serotonin 5-HT7 receptor agonist N-(4-cyanophenylmethyl)-4-(2-biphenyl)-1-piperazinehexanamide (LP-211) to improve in vitro microsomal stability: A case study. |
| AID1571119 | Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in cell membrane after 1.5 hrs by scintillation counting analysis | 2018 | MedChemComm, Nov-01, Volume: 9, Issue:11
| Search for a 5-CT alternative. |
| AID780760 | Displacement of [3H]-8-OH-DPAT from human 5HT1A receptor after 1.5 hrs | 2013 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 23, Issue:22
| Novel highly potent serotonin 5-HT7 receptor ligands: structural modifications to improve pharmacokinetic properties. |
| AID1067154 | Selectivity ratio of Ki for human 5HT1A receptor to Ki for human 5HT7 receptor | 2014 | Bioorganic & medicinal chemistry, Mar-01, Volume: 22, Issue:5
| Design, synthesis, radiolabeling and in vivo evaluation of potential positron emission tomography (PET) radioligands for brain imaging of the 5-HT₇ receptor. |
| AID780748 | Half life in mouse brain at 10 to 30 mg/kg, ip | 2013 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 23, Issue:22
| Novel highly potent serotonin 5-HT7 receptor ligands: structural modifications to improve pharmacokinetic properties. |
| AID1571120 | Displacement of [3H]-raclopride from recombinant human D2 receptor expressed in cell membrane measured after 1.5 hrs by scintillation counting method | 2018 | MedChemComm, Nov-01, Volume: 9, Issue:11
| Search for a 5-CT alternative. |
| AID780759 | Displacement of [3H]-prazosin from alpha1 adrenergic receptor in rat cerebral cortex membranes after 50 mins | 2013 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 23, Issue:22
| Novel highly potent serotonin 5-HT7 receptor ligands: structural modifications to improve pharmacokinetic properties. |
| AID1571117 | Displacement of [3H]LSD from human recombinant 5-HT5A receptor expressed in cell membrane after 1.5 hrs by scintillation counting analysis | 2018 | MedChemComm, Nov-01, Volume: 9, Issue:11
| Search for a 5-CT alternative. |
| AID1318801 | Stability in mouse liver microsomes assessed as oxidative metabolism by measuring drug recovery at 10 uM preincubated for 10 mins followed by NADPH addition measured after 30 mins by liquid chromatographic method | 2016 | European journal of medicinal chemistry, Sep-14, Volume: 120 | Structural modifications of the serotonin 5-HT7 receptor agonist N-(4-cyanophenylmethyl)-4-(2-biphenyl)-1-piperazinehexanamide (LP-211) to improve in vitro microsomal stability: A case study. |
| AID1318816 | Agonist activity at 5-HT7 receptor in embryonic day 15 C57BL/6 mouse cortex assessed as increase in neurite length at 100 nM after 2 hrs by DAPI staining based microscopy relative to control | 2016 | European journal of medicinal chemistry, Sep-14, Volume: 120 | Structural modifications of the serotonin 5-HT7 receptor agonist N-(4-cyanophenylmethyl)-4-(2-biphenyl)-1-piperazinehexanamide (LP-211) to improve in vitro microsomal stability: A case study. |
| AID780756 | Metabolic stability in rat liver S9 fractions at 10 uM after 30 mins by RP-HPLC analysis | 2013 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 23, Issue:22
| Novel highly potent serotonin 5-HT7 receptor ligands: structural modifications to improve pharmacokinetic properties. |
| AID1571115 | Displacement of [3H]8-OH-DPAT from recombinant human 5-HT1A receptor expressed in cell membrane after 1.5 hrs by scintillation counting analysis | 2018 | MedChemComm, Nov-01, Volume: 9, Issue:11
| Search for a 5-CT alternative. |
| AID1318817 | Agonist activity at 5-HT7 receptor in embryonic day 15 C57BL/6 mouse cortex assessed as increase in neurite length at 100 nM up to 24 hrs by DAPI staining based microscopy | 2016 | European journal of medicinal chemistry, Sep-14, Volume: 120 | Structural modifications of the serotonin 5-HT7 receptor agonist N-(4-cyanophenylmethyl)-4-(2-biphenyl)-1-piperazinehexanamide (LP-211) to improve in vitro microsomal stability: A case study. |
| AID699068 | Displacement of [3H]-5-CT from human cloned 5HT7 receptor | 2012 | Journal of medicinal chemistry, Jul-26, Volume: 55, Issue:14
| Investigations on the 1-(2-biphenyl)piperazine motif: identification of new potent and selective ligands for the serotonin(7) (5-HT(7)) receptor with agonist or antagonist action in vitro or ex vivo. |
| AID1318802 | Displacement of [3H]-LSD from human 5-HT7 receptor after 1.5 hrs by cell based assay | 2016 | European journal of medicinal chemistry, Sep-14, Volume: 120 | Structural modifications of the serotonin 5-HT7 receptor agonist N-(4-cyanophenylmethyl)-4-(2-biphenyl)-1-piperazinehexanamide (LP-211) to improve in vitro microsomal stability: A case study. |
| AID386657 | Cmax in CD1 albino mouse brain at 10 mg/kg, ip after 30 mins | 2008 | Journal of medicinal chemistry, Sep-25, Volume: 51, Issue:18
| Structural modifications of N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4-aryl-1-piperazinehexanamides: influence on lipophilicity and 5-HT7 receptor activity. Part III. |
| AID1571116 | Displacement of [3H]ketanserin from recombinant human 5-HT2A receptor expressed in cell membrane after 1.5 hrs by scintillation counting analysis | 2018 | MedChemComm, Nov-01, Volume: 9, Issue:11
| Search for a 5-CT alternative. |
| AID1318815 | Agonist activity at 5-HT7 receptor in embryonic day 15 C57BL/6 mouse striatum assessed as increase in neurite length at 100 nM after 2 hrs in presence of 5-HT7 receptor antagonist SB-269970 by DAPI staining based microscopic analysis | 2016 | European journal of medicinal chemistry, Sep-14, Volume: 120 | Structural modifications of the serotonin 5-HT7 receptor agonist N-(4-cyanophenylmethyl)-4-(2-biphenyl)-1-piperazinehexanamide (LP-211) to improve in vitro microsomal stability: A case study. |
| AID391746 | Displacement of [3H]8-OH-DPAT from human cloned 5HT1A receptor expressed in HEK293 cells | 2008 | Journal of medicinal chemistry, Sep-25, Volume: 51, Issue:18
| Structural modifications of N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4-aryl-1-piperazinehexanamides: influence on lipophilicity and 5-HT7 receptor activity. Part III. |
| AID1067155 | Selectivity ratio of Ki for human 5HT1A receptor to Ki for rat 5HT7 receptor | 2014 | Bioorganic & medicinal chemistry, Mar-01, Volume: 22, Issue:5
| Design, synthesis, radiolabeling and in vivo evaluation of potential positron emission tomography (PET) radioligands for brain imaging of the 5-HT₇ receptor. |
| AID1595179 | Agonist activity at 5-HT7 receptor (unknown origin) expressed in N1E-115 cells assessed as intracellular cAMP response amplitude by confocal laser scanning microscopy | | | |
| AID1318828 | Retention factor, logKw of compound in MeOH/0.01 M phosphate buffer at pH 7.4 by RP-HPLC method | 2016 | European journal of medicinal chemistry, Sep-14, Volume: 120 | Structural modifications of the serotonin 5-HT7 receptor agonist N-(4-cyanophenylmethyl)-4-(2-biphenyl)-1-piperazinehexanamide (LP-211) to improve in vitro microsomal stability: A case study. |
| AID1067156 | Binding affinity to rat 5HT7 receptor | 2014 | Bioorganic & medicinal chemistry, Mar-01, Volume: 22, Issue:5
| Design, synthesis, radiolabeling and in vivo evaluation of potential positron emission tomography (PET) radioligands for brain imaging of the 5-HT₇ receptor. |
| AID386651 | Cmax in CD1 albino mouse plasma at 10 mg/kg, ip after 30 mins | 2008 | Journal of medicinal chemistry, Sep-25, Volume: 51, Issue:18
| Structural modifications of N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4-aryl-1-piperazinehexanamides: influence on lipophilicity and 5-HT7 receptor activity. Part III. |
| AID1318810 | Agonist activity at 5-HT7 receptor in embryonic day 15 C57BL/6 mouse striatum assessed as increase in neurite length at 100 nM after 30 mins by DAPI staining based microscopy | 2016 | European journal of medicinal chemistry, Sep-14, Volume: 120 | Structural modifications of the serotonin 5-HT7 receptor agonist N-(4-cyanophenylmethyl)-4-(2-biphenyl)-1-piperazinehexanamide (LP-211) to improve in vitro microsomal stability: A case study. |
| AID1126169 | Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting | 2014 | European journal of medicinal chemistry, May-06, Volume: 78 | Solid-supported synthesis, molecular modeling, and biological activity of long-chain arylpiperazine derivatives with cyclic amino acid amide fragments as 5-HT(7) and 5-HT(1A) receptor ligands. |
| AID386662 | Selectivity for rat cloned 5HT7 over human cloned 5HT1A | 2008 | Journal of medicinal chemistry, Sep-25, Volume: 51, Issue:18
| Structural modifications of N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4-aryl-1-piperazinehexanamides: influence on lipophilicity and 5-HT7 receptor activity. Part III. |
| AID699064 | Binding affinity to rat cloned 5HT7 receptor | 2012 | Journal of medicinal chemistry, Jul-26, Volume: 55, Issue:14
| Investigations on the 1-(2-biphenyl)piperazine motif: identification of new potent and selective ligands for the serotonin(7) (5-HT(7)) receptor with agonist or antagonist action in vitro or ex vivo. |
| AID1571118 | Displacement of [3H]LSD from human recombinant 5-HT6 receptor expressed in cell membrane after 1.5 hrs by scintillation counting analysis | 2018 | MedChemComm, Nov-01, Volume: 9, Issue:11
| Search for a 5-CT alternative. |
| AID1318821 | Agonist activity at 5-HT7 receptor in embryonic day 15 C57BL/6 mouse cortex assessed as increase in neurite length at 100 nM after 2 hrs in presence of 5-HT7 receptor antagonist SB-269970 by DAPI staining based microscopic analysis | 2016 | European journal of medicinal chemistry, Sep-14, Volume: 120 | Structural modifications of the serotonin 5-HT7 receptor agonist N-(4-cyanophenylmethyl)-4-(2-biphenyl)-1-piperazinehexanamide (LP-211) to improve in vitro microsomal stability: A case study. |
| AID386656 | Ratio of plasma AUC to brain AUC in CD1 albino mouse | 2008 | Journal of medicinal chemistry, Sep-25, Volume: 51, Issue:18
| Structural modifications of N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4-aryl-1-piperazinehexanamides: influence on lipophilicity and 5-HT7 receptor activity. Part III. |
| AID1067153 | Displacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins | 2014 | Bioorganic & medicinal chemistry, Mar-01, Volume: 22, Issue:5
| Design, synthesis, radiolabeling and in vivo evaluation of potential positron emission tomography (PET) radioligands for brain imaging of the 5-HT₇ receptor. |
| AID1067152 | Displacement of [3H]8-OH-DPAT from human 5HT1A receptor transfected in HEK293-EBNA cells after 120 mins | 2014 | Bioorganic & medicinal chemistry, Mar-01, Volume: 22, Issue:5
| Design, synthesis, radiolabeling and in vivo evaluation of potential positron emission tomography (PET) radioligands for brain imaging of the 5-HT₇ receptor. |
| AID391745 | Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells | 2008 | Journal of medicinal chemistry, Sep-25, Volume: 51, Issue:18
| Structural modifications of N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4-aryl-1-piperazinehexanamides: influence on lipophilicity and 5-HT7 receptor activity. Part III. |
| AID1595154 | Agonist activity at 5-HT7 receptor (unknown origin) expressed in N1E-115 cells assessed as intracellular cAMP response time by confocal laser scanning microscopy | | | |
| AID1345788 | Human D2 receptor (Dopamine receptors) | 2008 | Journal of medicinal chemistry, Sep-25, Volume: 51, Issue:18
| Structural modifications of N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4-aryl-1-piperazinehexanamides: influence on lipophilicity and 5-HT7 receptor activity. Part III. |
| AID1345235 | Rat 5-HT7 receptor (5-Hydroxytryptamine receptors) | 2008 | Journal of medicinal chemistry, Sep-25, Volume: 51, Issue:18
| Structural modifications of N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4-aryl-1-piperazinehexanamides: influence on lipophilicity and 5-HT7 receptor activity. Part III. |
| AID1345615 | Human 5-HT1A receptor (5-Hydroxytryptamine receptors) | 2008 | Journal of medicinal chemistry, Sep-25, Volume: 51, Issue:18
| Structural modifications of N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4-aryl-1-piperazinehexanamides: influence on lipophilicity and 5-HT7 receptor activity. Part III. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |