norfloxacin has been researched along with Gram-Negative Bacterial Infections in 19 studies
Norfloxacin: A synthetic fluoroquinolone (FLUOROQUINOLONES) with broad-spectrum antibacterial activity against most gram-negative and gram-positive bacteria. Norfloxacin inhibits bacterial DNA GYRASE.
norfloxacin : A quinolinemonocarboxylic acid with broad-spectrum antibacterial activity against most gram-negative and gram-positive bacteria. Norfloxacin is bactericidal and its mode of action depends on blocking of bacterial DNA replication by binding itself to an enzyme called DNA gyrase.
Gram-Negative Bacterial Infections: Infections caused by bacteria that show up as pink (negative) when treated by the gram-staining method.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The effect of a combination regimen using norfloxacin (NFLX) and amphotericin B (AMPH-B) for prevention of infections in patients with acute leukemia being treated by remission-induction chemotherapy in a randomized, controlled trial was studied." | 9.07 | Prevention of bacterial and fungal infections in acute leukemia patients: a new and potent combination of oral norfloxacin and amphotericin B. ( Dan, K; Nomura, T; Yamada, T, 1993) |
| "The effect of a combination regimen using norfloxacin (NFLX) and amphotericin B (AMPH-B) for prevention of infections in patients with acute leukemia being treated by remission-induction chemotherapy in a randomized, controlled trial was studied." | 5.07 | Prevention of bacterial and fungal infections in acute leukemia patients: a new and potent combination of oral norfloxacin and amphotericin B. ( Dan, K; Nomura, T; Yamada, T, 1993) |
| "A total of 125 ambulatory women (85 premenopausal and 40 postmenopausal) who experienced 174 acute urinary tract infections with mainly gram-negative bacteria (99%) was randomized to receive a single dose, 2-tablet treatment with either ofloxacin (400 mg." | 5.07 | Single dose quinolone treatment in acute uncomplicated urinary tract infection in women. ( Pfau, A; Sacks, TG, 1993) |
| " Thirty patients were taking norfloxacin or trimethoprim-sulfamethoxazole as prophylaxis against bacterial peritonitis and 11 were not." | 3.76 | Effects of antibiotics on expression and function of Toll-like receptors 2 and 4 on mononuclear cells in patients with advanced cirrhosis. ( Angus, PW; Gow, PJ; Markovska, V; Skinner, N; Testro, AG; Visvanathan, K; Wongseelashote, S, 2010) |
| " Urine samples were taken every 2 h during the whole dosing interval of the particular antibiotic." | 1.33 | Urinary bactericidal activity of oral antibiotics against common urinary tract pathogens in an ex vivo model. ( Bedenic, B; Bubonja, M; Budimir, A; Topic, M, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (5.26) | 18.7374 |
| 1990's | 7 (36.84) | 18.2507 |
| 2000's | 6 (31.58) | 29.6817 |
| 2010's | 5 (26.32) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sánchez-Céspedes, J | 1 |
| Blasco, MD | 1 |
| Marti, S | 1 |
| Alba, V | 1 |
| Alcalde, E | 1 |
| Esteve, C | 1 |
| Vila, J | 1 |
| Shimizu, K | 1 |
| Kikuchi, K | 1 |
| Sasaki, T | 1 |
| Takahashi, N | 1 |
| Ohtsuka, M | 1 |
| Ono, Y | 1 |
| Hiramatsu, K | 1 |
| Makawana, JA | 1 |
| Mungra, DC | 1 |
| Patel, MP | 1 |
| Patel, RG | 1 |
| Lowrence, RC | 1 |
| Ramakrishnan, A | 1 |
| Sundaramoorthy, NS | 1 |
| Shyam, A | 1 |
| Mohan, V | 1 |
| Subbarao, HMV | 1 |
| Ulaganathan, V | 1 |
| Raman, T | 1 |
| Solomon, A | 1 |
| Nagarajan, S | 1 |
| Moreau, R | 2 |
| Elkrief, L | 1 |
| Bureau, C | 1 |
| Perarnau, JM | 1 |
| Thévenot, T | 1 |
| Saliba, F | 1 |
| Louvet, A | 1 |
| Nahon, P | 1 |
| Lannes, A | 1 |
| Anty, R | 1 |
| Hillaire, S | 1 |
| Pasquet, B | 1 |
| Ozenne, V | 1 |
| Rudler, M | 1 |
| Ollivier-Hourmand, I | 1 |
| Robic, MA | 1 |
| d'Alteroche, L | 1 |
| Di Martino, V | 1 |
| Ripault, MP | 1 |
| Pauwels, A | 1 |
| Grangé, JD | 2 |
| Carbonell, N | 1 |
| Bronowicki, JP | 1 |
| Payancé, A | 1 |
| Rautou, PE | 1 |
| Valla, D | 1 |
| Gault, N | 1 |
| Lebrec, D | 2 |
| Salerno, F | 1 |
| La Mura, V | 1 |
| Testro, AG | 1 |
| Gow, PJ | 1 |
| Angus, PW | 1 |
| Wongseelashote, S | 1 |
| Skinner, N | 1 |
| Markovska, V | 1 |
| Visvanathan, K | 1 |
| Rabiller, A | 1 |
| Nunes, H | 1 |
| Tazi, KA | 1 |
| Wartski, M | 1 |
| Dulmet, E | 1 |
| Libert, JM | 1 |
| Mougeot, C | 1 |
| Mazmanian, M | 1 |
| Humbert, M | 1 |
| Hervé, P | 1 |
| Orogade, AA | 1 |
| Akuse, RM | 1 |
| Sinha, S | 1 |
| Chattopadhyay, S | 1 |
| Bhattacharya, SK | 1 |
| Nair, GB | 1 |
| Ramamurthy, T | 1 |
| Liso, V | 1 |
| Specchia, G | 1 |
| Pavone, V | 1 |
| Pansini, N | 1 |
| Capalbo, S | 1 |
| Ostuni, A | 1 |
| Mastria, A | 1 |
| Colucci, A | 1 |
| Costantino, G | 1 |
| Bedenic, B | 1 |
| Topic, M | 1 |
| Budimir, A | 1 |
| Bubonja, M | 1 |
| Beam, TR | 1 |
| Yamada, T | 1 |
| Dan, K | 1 |
| Nomura, T | 1 |
| Del Favero, A | 1 |
| Menichetti, F | 1 |
| Pfau, A | 1 |
| Sacks, TG | 1 |
| Roulot, D | 1 |
| Pelletier, G | 1 |
| Pariente, EA | 1 |
| Denis, J | 1 |
| Ink, O | 1 |
| Blanc, P | 1 |
| Richardet, JP | 1 |
| Vinel, JP | 1 |
| Delisle, F | 1 |
| Fischer, D | 1 |
| Flahault, A | 1 |
| Amiot, X | 1 |
| Soriano, G | 1 |
| Guarner, C | 1 |
| Tomás, A | 1 |
| Anguera, A | 1 |
| Mirelis, B | 1 |
| Fernández, C | 1 |
| Herrero, M | 1 |
| Alonso, C | 1 |
| Vilardell, F | 1 |
| Zhang, YY | 1 |
| Zhun, BY | 1 |
| Jiang, SC | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Randomized, Double-Blind, Placebo-Controlled Trial Assessing Norfloxacin in the Prevention of Complications in Patients With Cirrhosis and Severe Liver Failure[NCT01037959] | Phase 3 | 291 participants (Actual) | Interventional | 2010-04-30 | Terminated (stopped due to lack of recruitement) | ||
| Rifaximin Prophylaxis Against Recurrence of Spontaneous Bacterial Peritonitis and Occurrence of Hepatorenal Syndrome in Decompensated Cirrhotic Egyptian Patients[NCT05621005] | Phase 2 | 104 participants (Actual) | Interventional | 2019-03-01 | Completed | ||
| Comparison of Daily Norfloxacin Versus Weekly Ciprofloxacin for the Prevention of Spontaneous Bacterial Peritonitis in Cirrhotic Patients[NCT01542801] | Phase 4 | 124 participants (Actual) | Interventional | 2011-08-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for norfloxacin and Gram-Negative Bacterial Infections
| Article | Year |
|---|---|
Quinolone therapy in intensive care unit settings.
Topics: Administration, Oral; Aged; Ciprofloxacin; Clinical Protocols; Clinical Trials as Topic; Cross Infec | 1993 |
5 trials available for norfloxacin and Gram-Negative Bacterial Infections
| Article | Year |
|---|---|
Effects of Long-term Norfloxacin Therapy in Patients With Advanced Cirrhosis.
Topics: Anti-Bacterial Agents; Ascites; Double-Blind Method; Female; France; Gram-Negative Bacterial Infecti | 2018 |
Effects of Long-term Norfloxacin Therapy in Patients With Advanced Cirrhosis.
Topics: Anti-Bacterial Agents; Ascites; Double-Blind Method; Female; France; Gram-Negative Bacterial Infecti | 2018 |
Effects of Long-term Norfloxacin Therapy in Patients With Advanced Cirrhosis.
Topics: Anti-Bacterial Agents; Ascites; Double-Blind Method; Female; France; Gram-Negative Bacterial Infecti | 2018 |
Effects of Long-term Norfloxacin Therapy in Patients With Advanced Cirrhosis.
Topics: Anti-Bacterial Agents; Ascites; Double-Blind Method; Female; France; Gram-Negative Bacterial Infecti | 2018 |
Prevention of bacterial and fungal infections in acute leukemia patients: a new and potent combination of oral norfloxacin and amphotericin B.
Topics: Administration, Oral; Adult; Amphotericin B; Antineoplastic Agents; Bacterial Infections; Drug Combi | 1993 |
Single dose quinolone treatment in acute uncomplicated urinary tract infection in women.
Topics: Acute Disease; Adult; Aged; Aged, 80 and over; Ciprofloxacin; Female; Gram-Negative Bacterial Infect | 1993 |
Norfloxacin primary prophylaxis of bacterial infections in cirrhotic patients with ascites: a double-blind randomized trial.
Topics: Adult; Aged; Anti-Infective Agents; Ascites; Double-Blind Method; Feces; Female; France; Gram-Negati | 1998 |
[Clinical evaluation of enoxacin].
Topics: Adult; Dysentery, Bacillary; Enoxacin; Female; Gram-Negative Bacterial Infections; Humans; Male; Mid | 1991 |
13 other studies available for norfloxacin and Gram-Negative Bacterial Infections
| Article | Year |
|---|---|
Plasmid-mediated QnrS2 determinant from a clinical Aeromonas veronii isolate.
Topics: Aeromonas; Ciprofloxacin; Drug Resistance, Bacterial; Genes, Bacterial; Gram-Negative Bacterial Infe | 2008 |
Smqnr, a new chromosome-carried quinolone resistance gene in Stenotrophomonas maltophilia.
Topics: Alleles; Amino Acid Sequence; Anti-Bacterial Agents; Base Sequence; Chromosomes, Bacterial; DNA Prim | 2008 |
Microwave assisted synthesis and antimicrobial evaluation of new fused pyran derivatives bearing 2-morpholinoquinoline nucleus.
Topics: Anti-Bacterial Agents; Anti-Infective Agents; Bacteria; Candida albicans; Fungi; Gram-Negative Bacte | 2011 |
Norfloxacin salts of carboxylic acids curtail planktonic and biofilm mode of growth in ESKAPE pathogens.
Topics: Acinetobacter baumannii; Animals; Anti-Bacterial Agents; Biofilms; Carboxylic Acids; Enterobacter; E | 2018 |
Treatment of Spontaneous Bacterial Peritonitis.
Topics: Age Factors; Albumins; Anti-Bacterial Agents; Antibiotic Prophylaxis; Ascites; Bilirubin; Drug Resis | 2015 |
Effects of antibiotics on expression and function of Toll-like receptors 2 and 4 on mononuclear cells in patients with advanced cirrhosis.
Topics: Adult; Aged; Anti-Bacterial Agents; Case-Control Studies; Female; Gram-Negative Bacterial Infections | 2010 |
Prevention of gram-negative translocation reduces the severity of hepatopulmonary syndrome.
Topics: Animals; Anti-Infective Agents; Antibiotic Prophylaxis; Bacterial Translocation; Common Bile Duct; D | 2002 |
Changing patterns in sensitivity of causative organisms of septicaemia in children: the need for quinolones.
Topics: Adolescent; Anti-Infective Agents; Child; Child, Preschool; Drug Resistance, Multiple, Bacterial; Gr | 2004 |
An unusually high level of quinolone resistance associated with type II topoisomerase mutations in quinolone resistance-determining regions of Aeromonas caviae isolated from diarrhoeal patients.
Topics: Aeromonas; Anti-Infective Agents; Base Sequence; Ciprofloxacin; Diarrhea; DNA Gyrase; DNA Topoisomer | 2004 |
Prophylactic administration of oral norfloxacin for prevention of gram-negative bacterial infections in patients with acute leukemias.
Topics: Acute Disease; Administration, Oral; Adolescent; Adult; Aged; Agranulocytosis; Antineoplastic Agents | 1989 |
Urinary bactericidal activity of oral antibiotics against common urinary tract pathogens in an ex vivo model.
Topics: Acetamides; Administration, Oral; Adult; Amoxicillin; Amoxicillin-Potassium Clavulanate Combination; | 2006 |
The new fluorinated quinolones for antimicrobial prophylaxis in neutropenic cancer patients.
Topics: Anti-Bacterial Agents; Anti-Infective Agents; Ciprofloxacin; Drug Therapy, Combination; Gram-Negativ | 1993 |
[The duration of the effect of norfloxacin on the fecal flora in cirrhosis patients].
Topics: Administration, Oral; Drug Evaluation; Feces; Gram-Negative Aerobic Bacteria; Gram-Negative Bacteria | 1992 |