Compounds > methyl 2-pyridyl disulfide
Page last updated: 2024-12-08

methyl 2-pyridyl disulfide

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Description

methyl 2-pyridyl disulfide: structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID173923
CHEMBL ID454604
SCHEMBL ID70383
MeSH IDM0107814

Synonyms (11)

Synonym
methyl 2-pyridyl disulfide
2-(methyldithio)pyridine
2-(2-methyldisulfanyl)pyridine
CHEMBL454604
2-(methyldisulfanyl)pyridine
pyssm
pyridine, 2-(methyldithio)-
63434-91-3
SCHEMBL70383
DTXSID60212849
methyl 2-pyridyl disulphide
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (24)

Assay IDTitleYearJournalArticle
AID1714671Antibacterial activity against vancomycin-resistant Enterococcus faecium ATCC 700221 assessed as zone of inhibition by disc diffusion method2018European journal of medicinal chemistry, Jan-01, Volume: 143Allicin-inspired pyridyl disulfides as antimicrobial agents for multidrug-resistant Staphylococcus aureus.
AID1714666Antibacterial activity against Enterobacter cloacae ATCC 23355 assessed as zone of inhibition by disc diffusion method2018European journal of medicinal chemistry, Jan-01, Volume: 143Allicin-inspired pyridyl disulfides as antimicrobial agents for multidrug-resistant Staphylococcus aureus.
AID1714665Antibacterial activity against multidrug-resistant Klebsiella pneumoniae ATCC 700603 assessed as zone of inhibition by disc diffusion method2018European journal of medicinal chemistry, Jan-01, Volume: 143Allicin-inspired pyridyl disulfides as antimicrobial agents for multidrug-resistant Staphylococcus aureus.
AID421760Antibacterial activity against Staphylococcus aureus SA1199B overexpressing NorA efflux pump after 72 hrs2009Journal of natural products, Mar-27, Volume: 72, Issue:3
Bioactive pyridine-N-oxide disulfides from Allium stipitatum.
AID421757Antibacterial activity against Mycobacterium smegmatis after 72 hrs2009Journal of natural products, Mar-27, Volume: 72, Issue:3
Bioactive pyridine-N-oxide disulfides from Allium stipitatum.
AID1714668Antibacterial activity against multidrug-resistant Acinetobacter baumannii BAA 1605 assessed as zone of inhibition by disc diffusion method2018European journal of medicinal chemistry, Jan-01, Volume: 143Allicin-inspired pyridyl disulfides as antimicrobial agents for multidrug-resistant Staphylococcus aureus.
AID421762Antibacterial activity against Staphylococcus aureus EMRSA15 after 72 hrs2009Journal of natural products, Mar-27, Volume: 72, Issue:3
Bioactive pyridine-N-oxide disulfides from Allium stipitatum.
AID1714679Antibacterial activity against Staphylococcus epidermidis ATCC 14990 assessed as zone of inhibition by disc diffusion method2018European journal of medicinal chemistry, Jan-01, Volume: 143Allicin-inspired pyridyl disulfides as antimicrobial agents for multidrug-resistant Staphylococcus aureus.
AID1714680Antibacterial activity against Acinetobacter baumannii ATCC 19606 assessed as zone of inhibition by disc diffusion method2018European journal of medicinal chemistry, Jan-01, Volume: 143Allicin-inspired pyridyl disulfides as antimicrobial agents for multidrug-resistant Staphylococcus aureus.
AID1714673Antibacterial activity against methicillin-susceptible Staphylococcus aureus ATCC 25923 assessed as zone of inhibition by disc diffusion method2018European journal of medicinal chemistry, Jan-01, Volume: 143Allicin-inspired pyridyl disulfides as antimicrobial agents for multidrug-resistant Staphylococcus aureus.
AID421758Antibacterial activity against Mycobacterium smegmatis mc2 2700 after 72 hrs2009Journal of natural products, Mar-27, Volume: 72, Issue:3
Bioactive pyridine-N-oxide disulfides from Allium stipitatum.
AID1714675Antibacterial activity against hospital acquired methicillin-resistant Staphylococcus aureus ATCC 43300 assessed as zone of inhibition by disc diffusion method2018European journal of medicinal chemistry, Jan-01, Volume: 143Allicin-inspired pyridyl disulfides as antimicrobial agents for multidrug-resistant Staphylococcus aureus.
AID1714667Antibacterial activity against beta-lactam resistant Escherichia coli BAA 2326 assessed as zone of inhibition by disc diffusion method2018European journal of medicinal chemistry, Jan-01, Volume: 143Allicin-inspired pyridyl disulfides as antimicrobial agents for multidrug-resistant Staphylococcus aureus.
AID406549Antibacterial activity against Staphylococcus aureus ATCC 25923 assessed as inhibition zone diameter at 20 ug after 24 hrs by Kirby-Bauer test2008Bioorganic & medicinal chemistry, Jul-01, Volume: 16, Issue:13
Unsymmetric aryl-alkyl disulfide growth inhibitors of methicillin-resistant Staphylococcus aureus and Bacillus anthracis.
AID1714676Antibacterial activity against heterogeneous vancomycin-intermediate resistant Staphylococcus aureus Mu3 ATCC 700698 assessed as zone of inhibition by disc diffusion method2018European journal of medicinal chemistry, Jan-01, Volume: 143Allicin-inspired pyridyl disulfides as antimicrobial agents for multidrug-resistant Staphylococcus aureus.
AID1714674Antibacterial activity against community acquired methicillin-resistant Staphylococcus aureus BAA 1747 assessed as zone of inhibition by disc diffusion method2018European journal of medicinal chemistry, Jan-01, Volume: 143Allicin-inspired pyridyl disulfides as antimicrobial agents for multidrug-resistant Staphylococcus aureus.
AID1714677Antibacterial activity against vancomycin-intermediate resistant Staphylococcus aureus Mu50 ATCC 700699 assessed as zone of inhibition by disc diffusion method2018European journal of medicinal chemistry, Jan-01, Volume: 143Allicin-inspired pyridyl disulfides as antimicrobial agents for multidrug-resistant Staphylococcus aureus.
AID421761Antibacterial activity against tetracycline-effluxing Staphylococcus aureus XU212 after 72 hrs2009Journal of natural products, Mar-27, Volume: 72, Issue:3
Bioactive pyridine-N-oxide disulfides from Allium stipitatum.
AID1714670Antibacterial activity against Bacillus anthracis Sterne 34F2 assessed as zone of inhibition by disc diffusion method2018European journal of medicinal chemistry, Jan-01, Volume: 143Allicin-inspired pyridyl disulfides as antimicrobial agents for multidrug-resistant Staphylococcus aureus.
AID421759Antibacterial activity against Mycobacterium phlei after 72 hrs2009Journal of natural products, Mar-27, Volume: 72, Issue:3
Bioactive pyridine-N-oxide disulfides from Allium stipitatum.
AID1714672Antibacterial activity against vancomycin-susceptible Enterococcus faecalis ATCC 29212 assessed as zone of inhibition by disc diffusion method2018European journal of medicinal chemistry, Jan-01, Volume: 143Allicin-inspired pyridyl disulfides as antimicrobial agents for multidrug-resistant Staphylococcus aureus.
AID1714681Antibacterial activity against Pseudomonas aeruginosa ATCC 15422 assessed as zone of inhibition by disc diffusion method2018European journal of medicinal chemistry, Jan-01, Volume: 143Allicin-inspired pyridyl disulfides as antimicrobial agents for multidrug-resistant Staphylococcus aureus.
AID1714678Antibacterial activity against vancomycin-resistant Staphylococcus aureus HIP11714 assessed as zone of inhibition by disc diffusion method2018European journal of medicinal chemistry, Jan-01, Volume: 143Allicin-inspired pyridyl disulfides as antimicrobial agents for multidrug-resistant Staphylococcus aureus.
AID421756Antibacterial activity against Mycobacterium fortuitum after 72 hrs2009Journal of natural products, Mar-27, Volume: 72, Issue:3
Bioactive pyridine-N-oxide disulfides from Allium stipitatum.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (7)

TimeframeStudies, This Drug (%)All Drugs %
pre-19903 (42.86)18.7374
1990's0 (0.00)18.2507
2000's2 (28.57)29.6817
2010's2 (28.57)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.24

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.24 (24.57)
Research Supply Index2.08 (2.92)
Research Growth Index4.32 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.24)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other7 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
oxyquinoline
Oxyquinoline: An antiseptic with mild fungistatic, bacteriostatic, anthelmintic, and amebicidal action. It is also used as a reagent and metal chelator, as a carrier for radio-indium for diagnostic purposes, and its halogenated derivatives are used in addition as topical anti-infective agents and oral antiamebics.. quinolin-8-ol : A monohydroxyquinoline that is quinoline substituted by a hydroxy group at position 8. Its fungicidal properties are used for the control of grey mould on vines and tomatoes.		2.0510monohydroxyquinolineantibacterial agent;
antifungal agrochemical;
antiseptic drug;
iron chelator
dipyrithione
[no description available]		2.0510pyridinium ion
disulfiram
[no description available]		1.9710organic disulfide;
organosulfur acaricide		angiogenesis inhibitor;
antineoplastic agent;
apoptosis inducer;
EC 1.2.1.3 [aldehyde dehydrogenase (NAD(+))] inhibitor;
EC 3.1.1.1 (carboxylesterase) inhibitor;
EC 3.1.1.8 (cholinesterase) inhibitor;
EC 5.99.1.2 (DNA topoisomerase) inhibitor;
ferroptosis inducer;
fungicide;
NF-kappaB inhibitor
iodoacetamide
[no description available]		2.0810
isoniazid
Hydra: A genus of freshwater polyps in the family Hydridae, order Hydroida, class HYDROZOA. They are of special interest because of their complex organization and because their adult organization corresponds roughly to the gastrula of higher animals.. hydrazide : Compounds derived from oxoacids RkE(=O)l(OH)m (l =/= 0) by replacing -OH by -NRNR2 (R groups are commonly H). (IUPAC).		2.0510carbohydrazideantitubercular agent;
drug allergen
vitamin k 3
Vitamin K 3: A synthetic naphthoquinone without the isoprenoid side chain and biological activity, but can be converted to active vitamin K2, menaquinone, after alkylation in vivo.		2.05101,4-naphthoquinones;
vitamin K		angiogenesis inhibitor;
antineoplastic agent;
EC 3.4.22.69 (SARS coronavirus main proteinase) inhibitor;
human urinary metabolite;
nutraceutical
methyl methanesulfonate
[no description available]		1.9610methanesulfonate esteralkylating agent;
apoptosis inducer;
carcinogenic agent;
genotoxin;
mutagen
norfloxacin
Norfloxacin: A synthetic fluoroquinolone (FLUOROQUINOLONES) with broad-spectrum antibacterial activity against most gram-negative and gram-positive bacteria. Norfloxacin inhibits bacterial DNA GYRASE.. norfloxacin : A quinolinemonocarboxylic acid with broad-spectrum antibacterial activity against most gram-negative and gram-positive bacteria. Norfloxacin is bactericidal and its mode of action depends on blocking of bacterial DNA replication by binding itself to an enzyme called DNA gyrase.		2.0510fluoroquinolone antibiotic;
N-arylpiperazine;
quinolinemonocarboxylic acid;
quinolone antibiotic;
quinolone		antibacterial drug;
DNA synthesis inhibitor;
environmental contaminant;
xenobiotic
triclosan
[no description available]		2.1710aromatic ether;
dichlorobenzene;
monochlorobenzenes;
phenols		antibacterial agent;
antimalarial;
drug allergen;
EC 1.3.1.9 [enoyl-[acyl-carrier-protein] reductase (NADH)] inhibitor;
EC 1.5.1.3 (dihydrofolate reductase) inhibitor;
fungicide;
persistent organic pollutant;
xenobiotic
penicillin g
Penicillin G: A penicillin derivative commonly used in the form of its sodium or potassium salts in the treatment of a variety of infections. It is effective against most gram-positive bacteria and against gram-negative cocci. It has also been used as an experimental convulsant because of its actions on GAMMA-AMINOBUTYRIC ACID mediated synaptic transmission.. benzylpenicillin : A penicillin in which the substituent at position 6 of the penam ring is a phenylacetamido group.		2.0410penicillin allergen;
penicillin		antibacterial drug;
drug allergen;
epitope
lysine
Lysine: An essential amino acid. It is often added to animal feed.. lysine : A diamino acid that is caproic (hexanoic) acid bearing two amino substituents at positions 2 and 6.. L-lysine : An L-alpha-amino acid; the L-isomer of lysine.		2.0810aspartate family amino acid;
L-alpha-amino acid zwitterion;
L-alpha-amino acid;
lysine;
organic molecular entity;
proteinogenic amino acid		algal metabolite;
anticonvulsant;
Escherichia coli metabolite;
human metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
plant metabolite;
Saccharomyces cerevisiae metabolite
oxacillin
Oxacillin: An antibiotic similar to FLUCLOXACILLIN used in resistant staphylococci infections.. oxacillin : A penicillin antibiotic carrying a 5-methyl-3-phenylisoxazole-4-carboxamide group at position 6beta.		2.0510penicillinantibacterial agent;
antibacterial drug
ditiocarb
Ditiocarb: A chelating agent that has been used to mobilize toxic metals from the tissues of humans and experimental animals. It is the main metabolite of DISULFIRAM.. diethyldithiocarbamic acid : A member of the class of dithiocarbamic acids that is diethylcarbamic acid in which both of the oxygens are replaced by sulfur.		1.9710dithiocarbamic acidschelator;
copper chelator
maleimide
[no description available]		2.0810dicarboximide;
maleimides		EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor
succinimide
succinimide: RN given refers to parent cpd. succinimide : A dicarboximide that is pyrrolidine which is substituted by oxo groups at positions 2 and 5.		2.0810dicarboximide;
pyrrolidinone
ethambutol
Ethambutol: An antitubercular agent that inhibits the transfer of mycolic acids into the cell wall of the tubercle bacillus. It may also inhibit the synthesis of spermidine in mycobacteria. The action is usually bactericidal, and the drug can penetrate human cell membranes to exert its lethal effect. (From Smith and Reynard, Textbook of Pharmacology, 1992, p863). ethambutol : An ethylenediamine derivative that is ethane-1,2-diamine in which one hydrogen attached to each of the nitrogens is sutstituted by a 1-hydroxybutan-2-yl group (S,S-configuration). It is a bacteriostatic antimycobacterial drug, effective against Mycobacterium tuberculosis and some other mycobacteria. It is used (as the dihydrochloride salt) in combination with other antituberculous drugs in the treatment of pulmonary and extrapulmonary tuberculosis; resistant strains of M. tuberculosis are readily produced if ethambutol is used alone.		2.0510ethanolamines;
ethylenediamine derivative		antitubercular agent;
environmental contaminant;
xenobiotic
vancomycin
Vancomycin: Antibacterial obtained from Streptomyces orientalis. It is a glycopeptide related to RISTOCETIN that inhibits bacterial cell wall assembly and is toxic to kidneys and the inner ear.. vancomycin : A complex glycopeptide from Streptomyces orientalis. It inhibits a specific step in the synthesis of the peptidoglycan layer in the Gram-positive bacteria Staphylococcus aureus and Clostridium difficile.		2.4920glycopeptideantibacterial drug;
antimicrobial agent;
bacterial metabolite
methyl methanethiosulfonate
S-methyl methanethiosulfonate : A sulfonic acid derivative obtained by condensaton of methanesulfonic acid with methanethiol.		1.9610sulfonic acid derivative;
thiosulfonate ester		metabolite
4,4'-dipyridyl disulfide
4,4'-dipyridyl disulfide : An organic disulfide obtained by formal oxidative dimerisation of 4-thiopyridine.		1.9710organic disulfide;
pyridines
n-propyl 2-pyridyl disulfide
[no description available]		2.1710
4-thiopyridine
4-thiopyridine: RN given refers to 4-thiopyridine cpd		1.9610
ConditionIndicatedRelationship StrengthStudiesTrials
Disease Models, Animal
Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.		02.0510