Assay ID | Title | Year | Journal | Article |
AID117684 | Protective dose in vivo was determined in acute, lethal systemic infections in female Charles River CD-1 mice against Streptococcus pyogenes C-203 | 1993 | Journal of medicinal chemistry, Jul-09, Volume: 36, Issue:14
| Quinolone antibacterials: synthesis and biological activity of carbon isosteres of the 1-piperazinyl and 3-amino-1-pyrrolidinyl side chains. |
AID133966 | In vivo potency against acute systemic infection in mouse caused by Pseudomonas aeruginosa. UI-18. on subcutaneous injection. | 1992 | Journal of medicinal chemistry, May-15, Volume: 35, Issue:10
| Quinolone antibacterial agents. Synthesis and structure-activity relationships of a series of amino acid prodrugs of racemic and chiral 7-(3-amino-1-pyrrolidinyl)quinolones. Highly soluble quinolone prodrugs with in vivo pseudomonas activity. |
AID23546 | Aqueous solubility | 1992 | Journal of medicinal chemistry, May-15, Volume: 35, Issue:10
| Quinolone antibacterial agents. Synthesis and structure-activity relationships of a series of amino acid prodrugs of racemic and chiral 7-(3-amino-1-pyrrolidinyl)quinolones. Highly soluble quinolone prodrugs with in vivo pseudomonas activity. |
AID51918 | Mammalian cell cytotoxicity test in chinese hamster V79 cells (clonogenic cytotoxicity) | 1992 | Journal of medicinal chemistry, Dec-11, Volume: 35, Issue:25
| Fluoroquinolones: relationships between structural variations, mammalian cell cytotoxicity, and antimicrobial activity. |
AID208922 | In vitro minimum inhibitory concentration against Streptococcus bovis A5169 using brain-heart infusion agar | 1992 | Journal of medicinal chemistry, Apr-17, Volume: 35, Issue:8
| Preparation and in vitro and in vivo evaluation of quinolones with selective activity against gram-positive organisms. |
AID163733 | Minimum inhibitory concentration was evaluated in vitro against Providencia rettgeri M1771 | 1993 | Journal of medicinal chemistry, Apr-02, Volume: 36, Issue:7
| Quinolone antibacterials containing the new 7-[3-(1-aminoethyl)-1- pyrrolidinyl] side chain: the effects of the 1-aminoethyl moiety and its stereochemical configurations on potency and in vivo efficacy. |
AID23549 | Solubility (at pH 7.4) | 1992 | Journal of medicinal chemistry, May-15, Volume: 35, Issue:10
| Quinolone antibacterial agents. Synthesis and structure-activity relationships of a series of amino acid prodrugs of racemic and chiral 7-(3-amino-1-pyrrolidinyl)quinolones. Highly soluble quinolone prodrugs with in vivo pseudomonas activity. |
AID164375 | Minimum inhibitory concentration was evaluated in vitro against Pseudomonas aeruginosa UI-18 | 1993 | Journal of medicinal chemistry, Apr-02, Volume: 36, Issue:7
| Quinolone antibacterials containing the new 7-[3-(1-aminoethyl)-1- pyrrolidinyl] side chain: the effects of the 1-aminoethyl moiety and its stereochemical configurations on potency and in vivo efficacy. |
AID53451 | Inhibition against DNA gyrase | 1993 | Journal of medicinal chemistry, Apr-02, Volume: 36, Issue:7
| Quinolone antibacterials containing the new 7-[3-(1-aminoethyl)-1- pyrrolidinyl] side chain: the effects of the 1-aminoethyl moiety and its stereochemical configurations on potency and in vivo efficacy. |
AID163051 | Minimum inhibitory concentration against Providencia rettgeri H1771 in vitro. | 1988 | Journal of medicinal chemistry, May, Volume: 31, Issue:5
| Quinolone antibacterial agents. Synthesis and structure-activity relationships of 8-substituted quinoline-3-carboxylic acids and 1,8-naphthyridine-3-carboxylic acids. |
AID69048 | Minimum concentration needed to produce linear DNA at an intensity relative to oxolinic at 10 ug/mL in Escherichia coli H560 in vitro. | 1988 | Journal of medicinal chemistry, May, Volume: 31, Issue:5
| Quinolone antibacterial agents. Synthesis and structure-activity relationships of 8-substituted quinoline-3-carboxylic acids and 1,8-naphthyridine-3-carboxylic acids. |
AID209247 | Minimum inhibitory concentration against Streptococcus faecalis MGH-2 in vitro. | 1988 | Journal of medicinal chemistry, May, Volume: 31, Issue:5
| Quinolone antibacterial agents. Synthesis and structure-activity relationships of 8-substituted quinoline-3-carboxylic acids and 1,8-naphthyridine-3-carboxylic acids. |
AID70282 | Antibacterial activity against Escherichia coli Vogel after oral administration in mouse | 1993 | Journal of medicinal chemistry, Apr-02, Volume: 36, Issue:7
| Quinolone antibacterials containing the new 7-[3-(1-aminoethyl)-1- pyrrolidinyl] side chain: the effects of the 1-aminoethyl moiety and its stereochemical configurations on potency and in vivo efficacy. |
AID133968 | In vivo potency against acute systemic infection in mouse caused by Streptococcus pneumoniae SV-1 on oral administration by gavage. | 1992 | Journal of medicinal chemistry, May-15, Volume: 35, Issue:10
| Quinolone antibacterial agents. Synthesis and structure-activity relationships of a series of amino acid prodrugs of racemic and chiral 7-(3-amino-1-pyrrolidinyl)quinolones. Highly soluble quinolone prodrugs with in vivo pseudomonas activity. |
AID210071 | Antibacterial activity measured as mouse protection against Streptococcus pyogenes C 203 after subcutaneous administration | 1993 | Journal of medicinal chemistry, Apr-02, Volume: 36, Issue:7
| Quinolone antibacterials containing the new 7-[3-(1-aminoethyl)-1- pyrrolidinyl] side chain: the effects of the 1-aminoethyl moiety and its stereochemical configurations on potency and in vivo efficacy. |
AID117682 | Protective dose in vivo was determined in acute, lethal systemic infections in female Charles River CD-1 mice against Escherichia coli Vogel | 1993 | Journal of medicinal chemistry, Jul-09, Volume: 36, Issue:14
| Quinolone antibacterials: synthesis and biological activity of carbon isosteres of the 1-piperazinyl and 3-amino-1-pyrrolidinyl side chains. |
AID66105 | In vitro minimum inhibitory concentration against Enterococcus faecium ATCC 8043 using brain-heart infusion agar | 1992 | Journal of medicinal chemistry, Apr-17, Volume: 35, Issue:8
| Preparation and in vitro and in vivo evaluation of quinolones with selective activity against gram-positive organisms. |
AID78549 | In vitro concentration inhibiting DNA gyrase induced cleavage in Escherichia coli H560 | 1992 | Journal of medicinal chemistry, May-15, Volume: 35, Issue:10
| Quinolone antibacterial agents. Synthesis and structure-activity relationships of a series of amino acid prodrugs of racemic and chiral 7-(3-amino-1-pyrrolidinyl)quinolones. Highly soluble quinolone prodrugs with in vivo pseudomonas activity. |
AID208301 | Minimum inhibitory concentration against Streptococcus pneumoniae SV-1 in vitro. | 1988 | Journal of medicinal chemistry, May, Volume: 31, Issue:5
| Quinolone antibacterial agents. Synthesis and structure-activity relationships of 8-substituted quinoline-3-carboxylic acids and 1,8-naphthyridine-3-carboxylic acids. |
AID201951 | In vitro antibacterial activity against gram positive Streptococcus pneumoniae SV-1. | 1992 | Journal of medicinal chemistry, May-15, Volume: 35, Issue:10
| Quinolone antibacterial agents. Synthesis and structure-activity relationships of a series of amino acid prodrugs of racemic and chiral 7-(3-amino-1-pyrrolidinyl)quinolones. Highly soluble quinolone prodrugs with in vivo pseudomonas activity. |
AID201273 | In vitro antibacterial activity against gram positive Staphylococcus aureus H-228. | 1992 | Journal of medicinal chemistry, May-15, Volume: 35, Issue:10
| Quinolone antibacterial agents. Synthesis and structure-activity relationships of a series of amino acid prodrugs of racemic and chiral 7-(3-amino-1-pyrrolidinyl)quinolones. Highly soluble quinolone prodrugs with in vivo pseudomonas activity. |
AID93881 | Minimum inhibitory concentration against Klebsiella pneumoniae MGH-2 in vitro. | 1988 | Journal of medicinal chemistry, May, Volume: 31, Issue:5
| Quinolone antibacterial agents. Synthesis and structure-activity relationships of 8-substituted quinoline-3-carboxylic acids and 1,8-naphthyridine-3-carboxylic acids. |
AID65397 | In vitro antibacterial activity against gram positive Enterococcus faecalis MGH-2. | 1992 | Journal of medicinal chemistry, May-15, Volume: 35, Issue:10
| Quinolone antibacterial agents. Synthesis and structure-activity relationships of a series of amino acid prodrugs of racemic and chiral 7-(3-amino-1-pyrrolidinyl)quinolones. Highly soluble quinolone prodrugs with in vivo pseudomonas activity. |
AID30275 | In vitro minimum inhibitory concentration against Acinetobacter CMX 669 using brain-heart infusion agar | 1992 | Journal of medicinal chemistry, Apr-17, Volume: 35, Issue:8
| Preparation and in vitro and in vivo evaluation of quinolones with selective activity against gram-positive organisms. |
AID68519 | Minimum inhibitory concentration against Enterobacter cloacae HA 2646 in vitro. | 1988 | Journal of medicinal chemistry, May, Volume: 31, Issue:5
| Quinolone antibacterial agents. Synthesis and structure-activity relationships of 8-substituted quinoline-3-carboxylic acids and 1,8-naphthyridine-3-carboxylic acids. |
AID117656 | In vivo potency against Staphylococcus aureus using mouse protection assay following p.o. administration. | 1988 | Journal of medicinal chemistry, May, Volume: 31, Issue:5
| Quinolone antibacterial agents. Synthesis and structure-activity relationships of 8-substituted quinoline-3-carboxylic acids and 1,8-naphthyridine-3-carboxylic acids. |
AID69639 | Minimum inhibitory concentration against Escherichia coli | 2000 | Journal of medicinal chemistry, Mar-23, Volume: 43, Issue:6
| Artificial neural network applied to prediction of fluorquinolone antibacterial activity by topological methods. |
AID41263 | In vitro antibacterial activity against Bacteroides fragilis BFA | 1995 | Journal of medicinal chemistry, Oct-27, Volume: 38, Issue:22
| The synthesis, structure-activity, and structure-side effect relationships of a series of 8-alkoxy- and 5-amino-8-alkoxyquinolone antibacterial agents. |
AID53322 | Inhibition of the gyrase mediated cleavage of supercoiled DNA | 1993 | Journal of medicinal chemistry, Jul-09, Volume: 36, Issue:14
| Quinolone antibacterials: synthesis and biological activity of carbon isosteres of the 1-piperazinyl and 3-amino-1-pyrrolidinyl side chains. |
AID133962 | In vivo potency against acute systemic infection in mouse caused by Escherichia coli vogel on subcutaneous injection. | 1992 | Journal of medicinal chemistry, May-15, Volume: 35, Issue:10
| Quinolone antibacterial agents. Synthesis and structure-activity relationships of a series of amino acid prodrugs of racemic and chiral 7-(3-amino-1-pyrrolidinyl)quinolones. Highly soluble quinolone prodrugs with in vivo pseudomonas activity. |
AID133970 | In vivo potency against acute systemic infection in mouse caused by Streptococcus pneumoniae SV-1 on subcutaneous injection. | 1992 | Journal of medicinal chemistry, May-15, Volume: 35, Issue:10
| Quinolone antibacterial agents. Synthesis and structure-activity relationships of a series of amino acid prodrugs of racemic and chiral 7-(3-amino-1-pyrrolidinyl)quinolones. Highly soluble quinolone prodrugs with in vivo pseudomonas activity. |
AID201409 | In vitro antibacterial activity against gram positive Staphylococcus aureus UC76. | 1992 | Journal of medicinal chemistry, May-15, Volume: 35, Issue:10
| Quinolone antibacterial agents. Synthesis and structure-activity relationships of a series of amino acid prodrugs of racemic and chiral 7-(3-amino-1-pyrrolidinyl)quinolones. Highly soluble quinolone prodrugs with in vivo pseudomonas activity. |
AID94148 | In vitro antibacterial activity against gram negative Klebsiella pneumoniae. MGH-2 | 1992 | Journal of medicinal chemistry, May-15, Volume: 35, Issue:10
| Quinolone antibacterial agents. Synthesis and structure-activity relationships of a series of amino acid prodrugs of racemic and chiral 7-(3-amino-1-pyrrolidinyl)quinolones. Highly soluble quinolone prodrugs with in vivo pseudomonas activity. |
AID202109 | In vitro antibacterial activity against gram positive Streptococcus pyogenes C-203. | 1992 | Journal of medicinal chemistry, May-15, Volume: 35, Issue:10
| Quinolone antibacterial agents. Synthesis and structure-activity relationships of a series of amino acid prodrugs of racemic and chiral 7-(3-amino-1-pyrrolidinyl)quinolones. Highly soluble quinolone prodrugs with in vivo pseudomonas activity. |
AID65233 | In vitro antibacterial activity against gram negative Escherichia coli Vogel. | 1992 | Journal of medicinal chemistry, May-15, Volume: 35, Issue:10
| Quinolone antibacterial agents. Synthesis and structure-activity relationships of a series of amino acid prodrugs of racemic and chiral 7-(3-amino-1-pyrrolidinyl)quinolones. Highly soluble quinolone prodrugs with in vivo pseudomonas activity. |
AID70772 | In vitro minimum inhibitory concentration against Escherichia coli Juhl using brain-heart infusion agar | 1992 | Journal of medicinal chemistry, Apr-17, Volume: 35, Issue:8
| Preparation and in vitro and in vivo evaluation of quinolones with selective activity against gram-positive organisms. |
AID203284 | In vitro minimum inhibitory concentration against Staphylococcus aureus A 5177 using brain-heart infusion agar | 1992 | Journal of medicinal chemistry, Apr-17, Volume: 35, Issue:8
| Preparation and in vitro and in vivo evaluation of quinolones with selective activity against gram-positive organisms. |
AID133972 | In vivo potency against acute systemic infection in mouse caused by Streptococcus pyogenes C-203 on oral administration by gavage | 1992 | Journal of medicinal chemistry, May-15, Volume: 35, Issue:10
| Quinolone antibacterial agents. Synthesis and structure-activity relationships of a series of amino acid prodrugs of racemic and chiral 7-(3-amino-1-pyrrolidinyl)quinolones. Highly soluble quinolone prodrugs with in vivo pseudomonas activity. |
AID210070 | Compounds were evaluated in vivo for antibacterial activity for mouse protection against Streptococcus pyogenes C 203 after oral administration | 1993 | Journal of medicinal chemistry, Apr-02, Volume: 36, Issue:7
| Quinolone antibacterials containing the new 7-[3-(1-aminoethyl)-1- pyrrolidinyl] side chain: the effects of the 1-aminoethyl moiety and its stereochemical configurations on potency and in vivo efficacy. |
AID69339 | Minimum inhibitory concentration against Escherichia coli H560 in vitro. | 1988 | Journal of medicinal chemistry, May, Volume: 31, Issue:5
| Quinolone antibacterial agents. Synthesis and structure-activity relationships of 8-substituted quinoline-3-carboxylic acids and 1,8-naphthyridine-3-carboxylic acids. |
AID160372 | In vitro antibacterial activity was tested for Propion acnes PA5-1 | 1995 | Journal of medicinal chemistry, Oct-27, Volume: 38, Issue:22
| The synthesis, structure-activity, and structure-side effect relationships of a series of 8-alkoxy- and 5-amino-8-alkoxyquinolone antibacterial agents. |
AID117657 | In vivo potency against Staphylococcus aureus using mouse protection assay following s.c. administration. | 1988 | Journal of medicinal chemistry, May, Volume: 31, Issue:5
| Quinolone antibacterial agents. Synthesis and structure-activity relationships of 8-substituted quinoline-3-carboxylic acids and 1,8-naphthyridine-3-carboxylic acids. |
AID67874 | In vitro minimum inhibitory concentration against Enterobacter aerogenes ATCC 13048 using brain-heart infusion agar | 1992 | Journal of medicinal chemistry, Apr-17, Volume: 35, Issue:8
| Preparation and in vitro and in vivo evaluation of quinolones with selective activity against gram-positive organisms. |
AID70283 | Antibacterial activity against Escherichia coli Vogel after subcutaneous administration in mouse | 1993 | Journal of medicinal chemistry, Apr-02, Volume: 36, Issue:7
| Quinolone antibacterials containing the new 7-[3-(1-aminoethyl)-1- pyrrolidinyl] side chain: the effects of the 1-aminoethyl moiety and its stereochemical configurations on potency and in vivo efficacy. |
AID68019 | Minimum inhibitory concentration in vitro against Enterobacter cloacae MA 2646 | 1993 | Journal of medicinal chemistry, Apr-02, Volume: 36, Issue:7
| Quinolone antibacterials containing the new 7-[3-(1-aminoethyl)-1- pyrrolidinyl] side chain: the effects of the 1-aminoethyl moiety and its stereochemical configurations on potency and in vivo efficacy. |
AID117659 | In vivo potency against Streptococcus pneumoniae using mouse protection assay following p.o. administration. | 1988 | Journal of medicinal chemistry, May, Volume: 31, Issue:5
| Quinolone antibacterial agents. Synthesis and structure-activity relationships of 8-substituted quinoline-3-carboxylic acids and 1,8-naphthyridine-3-carboxylic acids. |
AID203290 | In vitro minimum inhibitory concentration against Staphylococcus epidermidis 3159 using brain-heart infusion agar | 1992 | Journal of medicinal chemistry, Apr-17, Volume: 35, Issue:8
| Preparation and in vitro and in vivo evaluation of quinolones with selective activity against gram-positive organisms. |
AID163093 | Minimum inhibitory concentration against Pseudomonas aeruginosa UI-18 in vitro. | 1988 | Journal of medicinal chemistry, May, Volume: 31, Issue:5
| Quinolone antibacterial agents. Synthesis and structure-activity relationships of 8-substituted quinoline-3-carboxylic acids and 1,8-naphthyridine-3-carboxylic acids. |
AID210254 | In vitro minimum inhibitory concentration against Streptococcus pyogenes 930 using brain-heart infusion agar | 1992 | Journal of medicinal chemistry, Apr-17, Volume: 35, Issue:8
| Preparation and in vitro and in vivo evaluation of quinolones with selective activity against gram-positive organisms. |
AID96058 | Minimum inhibitory concentration was evaluated in vitro against Klebsiella pneumoniae MGH2 | 1993 | Journal of medicinal chemistry, Apr-02, Volume: 36, Issue:7
| Quinolone antibacterials containing the new 7-[3-(1-aminoethyl)-1- pyrrolidinyl] side chain: the effects of the 1-aminoethyl moiety and its stereochemical configurations on potency and in vivo efficacy. |
AID64389 | In vitro antibacterial activity against gram negative Enterobacter cloacae MA 2646. | 1992 | Journal of medicinal chemistry, May-15, Volume: 35, Issue:10
| Quinolone antibacterial agents. Synthesis and structure-activity relationships of a series of amino acid prodrugs of racemic and chiral 7-(3-amino-1-pyrrolidinyl)quinolones. Highly soluble quinolone prodrugs with in vivo pseudomonas activity. |
AID94220 | In vitro minimum inhibitory concentration against Klebsiella pneumoniae 8045 using brain-heart infusion agar | 1992 | Journal of medicinal chemistry, Apr-17, Volume: 35, Issue:8
| Preparation and in vitro and in vivo evaluation of quinolones with selective activity against gram-positive organisms. |
AID151528 | In vitro antibacterial activity against gram negative Pseudomonas aeruginosa UI-18. | 1992 | Journal of medicinal chemistry, May-15, Volume: 35, Issue:10
| Quinolone antibacterial agents. Synthesis and structure-activity relationships of a series of amino acid prodrugs of racemic and chiral 7-(3-amino-1-pyrrolidinyl)quinolones. Highly soluble quinolone prodrugs with in vivo pseudomonas activity. |
AID74728 | Geometric mean of MIC was determined in vitro against gram-negative strains using standard microtitration techniques | 1993 | Journal of medicinal chemistry, Jul-09, Volume: 36, Issue:14
| Quinolone antibacterials: synthesis and biological activity of carbon isosteres of the 1-piperazinyl and 3-amino-1-pyrrolidinyl side chains. |
AID164088 | In vitro minimum inhibitory concentration against Pseudomonas aeruginosa K799 / WT using brain-heart infusion agar | 1992 | Journal of medicinal chemistry, Apr-17, Volume: 35, Issue:8
| Preparation and in vitro and in vivo evaluation of quinolones with selective activity against gram-positive organisms. |
AID207045 | Minimum inhibitory concentration was evaluated in vitro against Staphylococcus aureus H 228 | 1993 | Journal of medicinal chemistry, Apr-02, Volume: 36, Issue:7
| Quinolone antibacterials containing the new 7-[3-(1-aminoethyl)-1- pyrrolidinyl] side chain: the effects of the 1-aminoethyl moiety and its stereochemical configurations on potency and in vivo efficacy. |
AID133960 | In vivo potency against acute systemic infection in mouse caused by Escherichia coli Vogel on oral administration by gavage. | 1992 | Journal of medicinal chemistry, May-15, Volume: 35, Issue:10
| Quinolone antibacterial agents. Synthesis and structure-activity relationships of a series of amino acid prodrugs of racemic and chiral 7-(3-amino-1-pyrrolidinyl)quinolones. Highly soluble quinolone prodrugs with in vivo pseudomonas activity. |
AID74727 | Antibacterial activity against five Gram-negative bacteria | 1992 | Journal of medicinal chemistry, Dec-11, Volume: 35, Issue:25
| Fluoroquinolones: relationships between structural variations, mammalian cell cytotoxicity, and antimicrobial activity. |
AID50999 | In vitro antibacterial activity against Clostridium perfringens CP 3-1 | 1995 | Journal of medicinal chemistry, Oct-27, Volume: 38, Issue:22
| The synthesis, structure-activity, and structure-side effect relationships of a series of 8-alkoxy- and 5-amino-8-alkoxyquinolone antibacterial agents. |
AID203286 | In vitro minimum inhibitory concentration against Staphylococcus aureus CMX 553 using brain-heart infusion agar | 1992 | Journal of medicinal chemistry, Apr-17, Volume: 35, Issue:8
| Preparation and in vitro and in vivo evaluation of quinolones with selective activity against gram-positive organisms. |
AID207547 | In vitro minimum inhibitory concentration against Staphylococcus aureus ATCC 6538P using brain-heart infusion agar | 1992 | Journal of medicinal chemistry, Apr-17, Volume: 35, Issue:8
| Preparation and in vitro and in vivo evaluation of quinolones with selective activity against gram-positive organisms. |
AID207974 | Minimum inhibitory concentration against Staphylococcus aureus H228 in vitro. | 1988 | Journal of medicinal chemistry, May, Volume: 31, Issue:5
| Quinolone antibacterial agents. Synthesis and structure-activity relationships of 8-substituted quinoline-3-carboxylic acids and 1,8-naphthyridine-3-carboxylic acids. |
AID208884 | In vitro minimum inhibitory concentration against Streptococcus agalactiae CMX 508 using brain-heart infusion agar | 1992 | Journal of medicinal chemistry, Apr-17, Volume: 35, Issue:8
| Preparation and in vitro and in vivo evaluation of quinolones with selective activity against gram-positive organisms. |
AID74853 | Antibacterial activity against five Gram-positive bacteria targeting topoisomerase II (DNA gyrase B GyrB) | 1992 | Journal of medicinal chemistry, Dec-11, Volume: 35, Issue:25
| Fluoroquinolones: relationships between structural variations, mammalian cell cytotoxicity, and antimicrobial activity. |
AID117660 | In vivo potency against Streptococcus pneumoniae using mouse protection assay following s.c. administration. | 1988 | Journal of medicinal chemistry, May, Volume: 31, Issue:5
| Quinolone antibacterial agents. Synthesis and structure-activity relationships of 8-substituted quinoline-3-carboxylic acids and 1,8-naphthyridine-3-carboxylic acids. |
AID163947 | In vitro minimum inhibitory concentration against Pseudomonas aeruginosa A5007 using brain-heart infusion agar | 1992 | Journal of medicinal chemistry, Apr-17, Volume: 35, Issue:8
| Preparation and in vitro and in vivo evaluation of quinolones with selective activity against gram-positive organisms. |
AID207046 | Minimum inhibitory concentration was evaluated in vitro against Staphylococcus aureus UC 76 | 1993 | Journal of medicinal chemistry, Apr-02, Volume: 36, Issue:7
| Quinolone antibacterials containing the new 7-[3-(1-aminoethyl)-1- pyrrolidinyl] side chain: the effects of the 1-aminoethyl moiety and its stereochemical configurations on potency and in vivo efficacy. |
AID208936 | Antibacterial activity expressed as Minimum inhibitory concentration was evaluated in vitro against Streptococcus pneumoniae SV-1 | 1993 | Journal of medicinal chemistry, Apr-02, Volume: 36, Issue:7
| Quinolone antibacterials containing the new 7-[3-(1-aminoethyl)-1- pyrrolidinyl] side chain: the effects of the 1-aminoethyl moiety and its stereochemical configurations on potency and in vivo efficacy. |
AID213589 | Clonogenic cytotoxicity against hamster V-79 cells | 1993 | Journal of medicinal chemistry, Apr-02, Volume: 36, Issue:7
| Quinolone antibacterials containing the new 7-[3-(1-aminoethyl)-1- pyrrolidinyl] side chain: the effects of the 1-aminoethyl moiety and its stereochemical configurations on potency and in vivo efficacy. |
AID213606 | Clonogenic cytotoxicity against Chinese hamster V-79 cells | 1995 | Journal of medicinal chemistry, Oct-27, Volume: 38, Issue:22
| The synthesis, structure-activity, and structure-side effect relationships of a series of 8-alkoxy- and 5-amino-8-alkoxyquinolone antibacterial agents. |
AID69340 | Minimum inhibitory concentration against Escherichia coli vogel in vitro. | 1988 | Journal of medicinal chemistry, May, Volume: 31, Issue:5
| Quinolone antibacterial agents. Synthesis and structure-activity relationships of 8-substituted quinoline-3-carboxylic acids and 1,8-naphthyridine-3-carboxylic acids. |
AID117862 | Phototoxic skin reaction in depilated female CD-1 mice | 1995 | Journal of medicinal chemistry, Oct-27, Volume: 38, Issue:22
| The synthesis, structure-activity, and structure-side effect relationships of a series of 8-alkoxy- and 5-amino-8-alkoxyquinolone antibacterial agents. |
AID50848 | In vitro antibacterial activity was tested for Clostridium diff CD1-1 | 1995 | Journal of medicinal chemistry, Oct-27, Volume: 38, Issue:22
| The synthesis, structure-activity, and structure-side effect relationships of a series of 8-alkoxy- and 5-amino-8-alkoxyquinolone antibacterial agents. |
AID157244 | In vitro antibacterial activity was tested for Pepto asac PA 3-1 | 1995 | Journal of medicinal chemistry, Oct-27, Volume: 38, Issue:22
| The synthesis, structure-activity, and structure-side effect relationships of a series of 8-alkoxy- and 5-amino-8-alkoxyquinolone antibacterial agents. |
AID23544 | Solubility (at pH 4) | 1992 | Journal of medicinal chemistry, May-15, Volume: 35, Issue:10
| Quinolone antibacterial agents. Synthesis and structure-activity relationships of a series of amino acid prodrugs of racemic and chiral 7-(3-amino-1-pyrrolidinyl)quinolones. Highly soluble quinolone prodrugs with in vivo pseudomonas activity. |
AID124937 | phototoxic skin reaction in depilated female CD-1 mice | 1995 | Journal of medicinal chemistry, Oct-27, Volume: 38, Issue:22
| The synthesis, structure-activity, and structure-side effect relationships of a series of 8-alkoxy- and 5-amino-8-alkoxyquinolone antibacterial agents. |
AID209759 | Minimum inhibitory concentration against Streptococcus pyogenes C203 in vitro. | 1988 | Journal of medicinal chemistry, May, Volume: 31, Issue:5
| Quinolone antibacterial agents. Synthesis and structure-activity relationships of 8-substituted quinoline-3-carboxylic acids and 1,8-naphthyridine-3-carboxylic acids. |
AID130070 | Compound was evaluated for phototoxicity no-effect dose in mouse | 1993 | Journal of medicinal chemistry, Apr-02, Volume: 36, Issue:7
| Quinolone antibacterials containing the new 7-[3-(1-aminoethyl)-1- pyrrolidinyl] side chain: the effects of the 1-aminoethyl moiety and its stereochemical configurations on potency and in vivo efficacy. |
AID74854 | Geometric mean of MIC was determined in vitro against gram-positive strains using standard microtitration techniques | 1993 | Journal of medicinal chemistry, Jul-09, Volume: 36, Issue:14
| Quinolone antibacterials: synthesis and biological activity of carbon isosteres of the 1-piperazinyl and 3-amino-1-pyrrolidinyl side chains. |
AID133974 | In vivo potency against acute systemic infection in mouse caused by Streptococcus pyogenes C-203 on subcutaneous injection | 1992 | Journal of medicinal chemistry, May-15, Volume: 35, Issue:10
| Quinolone antibacterial agents. Synthesis and structure-activity relationships of a series of amino acid prodrugs of racemic and chiral 7-(3-amino-1-pyrrolidinyl)quinolones. Highly soluble quinolone prodrugs with in vivo pseudomonas activity. |
AID23542 | Solubility (in 0.1 N HCl) | 1992 | Journal of medicinal chemistry, May-15, Volume: 35, Issue:10
| Quinolone antibacterial agents. Synthesis and structure-activity relationships of a series of amino acid prodrugs of racemic and chiral 7-(3-amino-1-pyrrolidinyl)quinolones. Highly soluble quinolone prodrugs with in vivo pseudomonas activity. |
AID209130 | Minimum inhibitory concentration was evaluated in vitro against Streptococcus pyogenes C 203 | 1993 | Journal of medicinal chemistry, Apr-02, Volume: 36, Issue:7
| Quinolone antibacterials containing the new 7-[3-(1-aminoethyl)-1- pyrrolidinyl] side chain: the effects of the 1-aminoethyl moiety and its stereochemical configurations on potency and in vivo efficacy. |
AID67884 | Minimum inhibitory concentration was evaluated in vitro against Enterococcus faecalis MGH-2 | 1993 | Journal of medicinal chemistry, Apr-02, Volume: 36, Issue:7
| Quinolone antibacterials containing the new 7-[3-(1-aminoethyl)-1- pyrrolidinyl] side chain: the effects of the 1-aminoethyl moiety and its stereochemical configurations on potency and in vivo efficacy. |
AID117655 | In vivo potency against Escherichia coli vogel using mouse protection assay when given subcutaneously | 1988 | Journal of medicinal chemistry, May, Volume: 31, Issue:5
| Quinolone antibacterial agents. Synthesis and structure-activity relationships of 8-substituted quinoline-3-carboxylic acids and 1,8-naphthyridine-3-carboxylic acids. |
AID133965 | In vivo potency against acute systemic infection in mouse caused by Pseudomonas aeruginosa UI-18 on oral administration by gavage. | 1992 | Journal of medicinal chemistry, May-15, Volume: 35, Issue:10
| Quinolone antibacterial agents. Synthesis and structure-activity relationships of a series of amino acid prodrugs of racemic and chiral 7-(3-amino-1-pyrrolidinyl)quinolones. Highly soluble quinolone prodrugs with in vivo pseudomonas activity. |
AID117654 | In vivo potency against Escherichia coli vogel using mouse protection assay when given perorally | 1988 | Journal of medicinal chemistry, May, Volume: 31, Issue:5
| Quinolone antibacterial agents. Synthesis and structure-activity relationships of 8-substituted quinoline-3-carboxylic acids and 1,8-naphthyridine-3-carboxylic acids. |
AID152317 | In vitro antibacterial activity against gram negative Providencia rettgeri M-1771. | 1992 | Journal of medicinal chemistry, May-15, Volume: 35, Issue:10
| Quinolone antibacterial agents. Synthesis and structure-activity relationships of a series of amino acid prodrugs of racemic and chiral 7-(3-amino-1-pyrrolidinyl)quinolones. Highly soluble quinolone prodrugs with in vivo pseudomonas activity. |
AID207975 | Minimum inhibitory concentration against Staphylococcus aureus UC-76 in vitro. | 1988 | Journal of medicinal chemistry, May, Volume: 31, Issue:5
| Quinolone antibacterial agents. Synthesis and structure-activity relationships of 8-substituted quinoline-3-carboxylic acids and 1,8-naphthyridine-3-carboxylic acids. |
AID69759 | Antibacterial activity in vitro against Escherichia coli Vogel | 1993 | Journal of medicinal chemistry, Apr-02, Volume: 36, Issue:7
| Quinolone antibacterials containing the new 7-[3-(1-aminoethyl)-1- pyrrolidinyl] side chain: the effects of the 1-aminoethyl moiety and its stereochemical configurations on potency and in vivo efficacy. |
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |