norfloxacin has been researched along with Esophageal and Gastric Varices in 5 studies
Norfloxacin: A synthetic fluoroquinolone (FLUOROQUINOLONES) with broad-spectrum antibacterial activity against most gram-negative and gram-positive bacteria. Norfloxacin inhibits bacterial DNA GYRASE.
norfloxacin : A quinolinemonocarboxylic acid with broad-spectrum antibacterial activity against most gram-negative and gram-positive bacteria. Norfloxacin is bactericidal and its mode of action depends on blocking of bacterial DNA replication by binding itself to an enzyme called DNA gyrase.
Esophageal and Gastric Varices: Dilated blood vessels in the ESOPHAGUS or GASTRIC FUNDUS that shunt blood from the portal circulation (PORTAL SYSTEM) to the systemic venous circulation. Often they are observed in individuals with portal hypertension (HYPERTENSION, PORTAL).
| Excerpt | Relevance | Reference |
|---|---|---|
| " A total of 94 cirrhotic patients having large oesophageal varices without history of variceal bleeding were randomized to three treatment groups and given 2 months' treatment with propranolol plus placebo, propranolol plus antibiotics (norfloxacin 400 mg BD) or propranolol plus probiotic (VSL#3, 900 billion/day) randomly assigned in 1:1:1 ratio." | 5.17 | Effects of the adjunctive probiotic VSL#3 on portal haemodynamics in patients with cirrhosis and large varices: a randomized trial. ( Garg, V; Gupta, N; Kumar, A; Sarin, SK; Sharma, BC; Sharma, P, 2013) |
| "Due to a high number of bacterial infections antibiotics administration has been indicated in these patients." | 2.71 | [Factors participating in development of bleeding varices in portal hypertension. Part I: bacterial infection and comparison of intravenous and peroral antibiotics effects--a randomised study]. ( Dastych, M; Díte, P; Husová, L; Juránková, J; Lata, J; Príbramská, V; Senkyrík, M, 2004) |
| "To determine the prevalence of bacterial infection in patients admitted to hospital with variceal bleeding in comparison with patients with liver cirrhosis admitted because of another reason." | 2.71 | Variceal bleeding in portal hypertension: bacterial infection and comparison of efficacy of intravenous and per-oral application of antibiotics--a randomized trial. ( Dastych, M; Díte, P; Husová, L; Juránková, J; Kroupa, R; Lata, J; Príbramská, V; Senkyrík, M, 2005) |
| "Bacterial infections are common in cirrhotic patients with acute variceal bleeding, occurring in 20% within 48 h." | 2.50 | Role of prophylactic antibiotics in cirrhotic patients with variceal bleeding. ( Lee, YY; Mahadeva, S; Tee, HP, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (40.00) | 29.6817 |
| 2010's | 3 (60.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gupta, N | 1 |
| Kumar, A | 1 |
| Sharma, P | 1 |
| Garg, V | 1 |
| Sharma, BC | 1 |
| Sarin, SK | 1 |
| Lee, YY | 1 |
| Tee, HP | 1 |
| Mahadeva, S | 1 |
| Salerno, F | 1 |
| La Mura, V | 1 |
| Lata, J | 2 |
| Juránková, J | 2 |
| Husová, L | 2 |
| Senkyrík, M | 2 |
| Díte, P | 2 |
| Dastych, M | 2 |
| Príbramská, V | 2 |
| Kroupa, R | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Endoscopic and Microbiological Assessment of the Effect of Carvedilol Combined With Berberine on GOV in Cirrhosis: a Prospective Cohort Study[NCT04543643] | Phase 3 | 288 participants (Anticipated) | Interventional | 2021-11-01 | Not yet recruiting | ||
| Comparison of 3 Days and 7 Days Intravenous Ceftriaxone Prophylaxis in Patients With Acute Variceal Bleeding[NCT00838864] | Phase 4 | 79 participants (Actual) | Interventional | 2009-03-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for norfloxacin and Esophageal and Gastric Varices
| Article | Year |
|---|---|
Role of prophylactic antibiotics in cirrhotic patients with variceal bleeding.
Topics: Anti-Bacterial Agents; Antibiotic Prophylaxis; Bacterial Infections; Ciprofloxacin; Endoscopy; Esoph | 2014 |
3 trials available for norfloxacin and Esophageal and Gastric Varices
| Article | Year |
|---|---|
Effects of the adjunctive probiotic VSL#3 on portal haemodynamics in patients with cirrhosis and large varices: a randomized trial.
Topics: Adult; Analysis of Variance; Anti-Bacterial Agents; Biomarkers; Chi-Square Distribution; Combined Mo | 2013 |
[Factors participating in development of bleeding varices in portal hypertension. Part I: bacterial infection and comparison of intravenous and peroral antibiotics effects--a randomised study].
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Ampicillin; Anti-Bacterial Agents; Bacterial I | 2004 |
Variceal bleeding in portal hypertension: bacterial infection and comparison of efficacy of intravenous and per-oral application of antibiotics--a randomized trial.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Ampicillin; Anti-Bacterial Agents; Bacterial I | 2005 |
1 other study available for norfloxacin and Esophageal and Gastric Varices
| Article | Year |
|---|---|
Treatment of Spontaneous Bacterial Peritonitis.
Topics: Age Factors; Albumins; Anti-Bacterial Agents; Antibiotic Prophylaxis; Ascites; Bilirubin; Drug Resis | 2015 |