norfloxacin has been researched along with Hypertension, Portal in 6 studies
Norfloxacin: A synthetic fluoroquinolone (FLUOROQUINOLONES) with broad-spectrum antibacterial activity against most gram-negative and gram-positive bacteria. Norfloxacin inhibits bacterial DNA GYRASE.
norfloxacin : A quinolinemonocarboxylic acid with broad-spectrum antibacterial activity against most gram-negative and gram-positive bacteria. Norfloxacin is bactericidal and its mode of action depends on blocking of bacterial DNA replication by binding itself to an enzyme called DNA gyrase.
Hypertension, Portal: Abnormal increase of resistance to blood flow within the hepatic PORTAL SYSTEM, frequently seen in LIVER CIRRHOSIS and conditions with obstruction of the PORTAL VEIN.
| Excerpt | Relevance | Reference |
|---|---|---|
| " A total of 94 cirrhotic patients having large oesophageal varices without history of variceal bleeding were randomized to three treatment groups and given 2 months' treatment with propranolol plus placebo, propranolol plus antibiotics (norfloxacin 400 mg BD) or propranolol plus probiotic (VSL#3, 900 billion/day) randomly assigned in 1:1:1 ratio." | 5.17 | Effects of the adjunctive probiotic VSL#3 on portal haemodynamics in patients with cirrhosis and large varices: a randomized trial. ( Garg, V; Gupta, N; Kumar, A; Sarin, SK; Sharma, BC; Sharma, P, 2013) |
| " We investigated the haemodynamic and vascular effects of norfloxacin in rats with secondary biliary cirrhosis." | 3.75 | Lack of effect of norfloxacin on hyperdynamic circulation in bile duct-ligated rats despite reduction of endothelial nitric oxide synthase function: result of unchanged vascular Rho-kinase? ( Buecher, D; Heller, J; Hennenberg, M; Sauerbruch, T; Trebicka, J, 2009) |
| "Norfloxacin therapy was not superior to placebo in reducing HVPG (13." | 2.74 | Norfloxacin treatment for clinically significant portal hypertension: results of a randomised double-blind placebo-controlled crossover trial. ( Chin-Dusting, J; Colman, J; Kemp, W; Kompa, A; Krum, H; Madan, A; Roberts, S; Thompson, K; Vincent, M, 2009) |
| "Due to a high number of bacterial infections antibiotics administration has been indicated in these patients." | 2.71 | [Factors participating in development of bleeding varices in portal hypertension. Part I: bacterial infection and comparison of intravenous and peroral antibiotics effects--a randomised study]. ( Dastych, M; Díte, P; Husová, L; Juránková, J; Lata, J; Príbramská, V; Senkyrík, M, 2004) |
| "To determine the prevalence of bacterial infection in patients admitted to hospital with variceal bleeding in comparison with patients with liver cirrhosis admitted because of another reason." | 2.71 | Variceal bleeding in portal hypertension: bacterial infection and comparison of efficacy of intravenous and per-oral application of antibiotics--a randomized trial. ( Dastych, M; Díte, P; Husová, L; Juránková, J; Kroupa, R; Lata, J; Príbramská, V; Senkyrík, M, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (66.67) | 29.6817 |
| 2010's | 1 (16.67) | 24.3611 |
| 2020's | 1 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Mendoza, YP | 1 |
| Rodrigues, SG | 1 |
| Bosch, J | 1 |
| Berzigotti, A | 1 |
| Gupta, N | 1 |
| Kumar, A | 1 |
| Sharma, P | 1 |
| Garg, V | 1 |
| Sharma, BC | 1 |
| Sarin, SK | 1 |
| Kemp, W | 1 |
| Colman, J | 1 |
| Thompson, K | 1 |
| Madan, A | 1 |
| Vincent, M | 1 |
| Chin-Dusting, J | 1 |
| Kompa, A | 1 |
| Krum, H | 1 |
| Roberts, S | 1 |
| Hennenberg, M | 1 |
| Trebicka, J | 1 |
| Buecher, D | 1 |
| Heller, J | 1 |
| Sauerbruch, T | 1 |
| Lata, J | 2 |
| Juránková, J | 2 |
| Husová, L | 2 |
| Senkyrík, M | 2 |
| Díte, P | 2 |
| Dastych, M | 2 |
| Príbramská, V | 2 |
| Kroupa, R | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Endoscopic and Microbiological Assessment of the Effect of Carvedilol Combined With Berberine on GOV in Cirrhosis: a Prospective Cohort Study[NCT04543643] | Phase 3 | 288 participants (Anticipated) | Interventional | 2021-11-01 | Not yet recruiting | ||
| Comparison of 3 Days and 7 Days Intravenous Ceftriaxone Prophylaxis in Patients With Acute Variceal Bleeding[NCT00838864] | Phase 4 | 79 participants (Actual) | Interventional | 2009-03-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for norfloxacin and Hypertension, Portal
| Article | Year |
|---|---|
Effect of poorly absorbable antibiotics on hepatic venous pressure gradient in cirrhosis: A systematic review and meta-analysis.
Topics: Adrenergic beta-Antagonists; Anti-Bacterial Agents; Bacterial Translocation; Drug Therapy, Combinati | 2020 |
4 trials available for norfloxacin and Hypertension, Portal
| Article | Year |
|---|---|
Effects of the adjunctive probiotic VSL#3 on portal haemodynamics in patients with cirrhosis and large varices: a randomized trial.
Topics: Adult; Analysis of Variance; Anti-Bacterial Agents; Biomarkers; Chi-Square Distribution; Combined Mo | 2013 |
Norfloxacin treatment for clinically significant portal hypertension: results of a randomised double-blind placebo-controlled crossover trial.
Topics: Anti-Bacterial Agents; Arginine; Cross-Over Studies; Endotoxemia; Humans; Hypertension, Portal; Live | 2009 |
[Factors participating in development of bleeding varices in portal hypertension. Part I: bacterial infection and comparison of intravenous and peroral antibiotics effects--a randomised study].
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Ampicillin; Anti-Bacterial Agents; Bacterial I | 2004 |
Variceal bleeding in portal hypertension: bacterial infection and comparison of efficacy of intravenous and per-oral application of antibiotics--a randomized trial.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Ampicillin; Anti-Bacterial Agents; Bacterial I | 2005 |
1 other study available for norfloxacin and Hypertension, Portal
| Article | Year |
|---|---|
Lack of effect of norfloxacin on hyperdynamic circulation in bile duct-ligated rats despite reduction of endothelial nitric oxide synthase function: result of unchanged vascular Rho-kinase?
Topics: Animals; Anti-Bacterial Agents; Aorta; Bile Ducts; Blotting, Western; Electromyography; Hypertension | 2009 |