Compounds > n-desmethylrufloxacin
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n-desmethylrufloxacin

Description

N-desmethylrufloxacin: structure given in first source; metabolite of rufloxacin found in urine of Rhesus monkey Macaca mulatta [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID127796
CHEMBL ID330932
SCHEMBL ID6301660
MeSH IDM0200197

Synonyms (10)

Synonym
mf 922
n-desmethylrufloxacin
CHEMBL330932
mf-922
101337-87-5
7h-pyrido(1,2,3-de)-1,4-benzothiazine-6-carboxylic acid, 9-fluoro-2,3-dihydro-7-oxo-10-(1-piperazinyl)-
SCHEMBL6301660
DTXSID80143863
7-fluoro-10-oxo-6-piperazin-1-yl-4-thia-1-azatricyclo[7.3.1.05,13]trideca-5(13),6,8,11-tetraene-11-carboxylic acid
8-fluoro-6-oxo-9-piperazin-1-yl-2,3-dihydro-6h-1-thia-3a-aza-phenalene-5-carboxylic acid

Bioassays (9)

Assay IDTitleYearJournalArticle
AID14382Urinary excretion in rat after 8-24 hours of oral administration at 50 mg/kg1993Journal of medicinal chemistry, Oct-29, Volume: 36, Issue:22
Quinolinecarboxylic acids. 3. Synthesis and antibacterial evaluation of 2-substituted-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de] [1,4]benzothiazine-6-carboxylic acids related to rufloxacin.
AID165055In vitro antibacterial activity against clinical isolates of Pseudomonas aeruginosa 2437 (gram negative) by agar dilution assay.1987Journal of medicinal chemistry, Mar, Volume: 30, Issue:3
Quinolonecarboxylic acids. 2. Synthesis and antibacterial evaluation of 7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzothiazine-6-carboxylic acids.
AID14381Urinary excretion in rat after 4-8 hours of oral administration at 50 mg/kg1993Journal of medicinal chemistry, Oct-29, Volume: 36, Issue:22
Quinolinecarboxylic acids. 3. Synthesis and antibacterial evaluation of 2-substituted-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de] [1,4]benzothiazine-6-carboxylic acids related to rufloxacin.
AID206437In vitro antibacterial activity against clinical isolates of Staphylococcus aureus 18773 (gram-positive) by agar dilution assay.1987Journal of medicinal chemistry, Mar, Volume: 30, Issue:3
Quinolonecarboxylic acids. 2. Synthesis and antibacterial evaluation of 7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzothiazine-6-carboxylic acids.
AID14380Urinary excretion in rat after 0-4 hours of oral administration at 50 mg/kg1993Journal of medicinal chemistry, Oct-29, Volume: 36, Issue:22
Quinolinecarboxylic acids. 3. Synthesis and antibacterial evaluation of 2-substituted-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de] [1,4]benzothiazine-6-carboxylic acids related to rufloxacin.
AID68201In vitro antibacterial activity against clinical isolates of Enterobacter cloacae 041 (gram negative) by agar dilution assay.1987Journal of medicinal chemistry, Mar, Volume: 30, Issue:3
Quinolonecarboxylic acids. 2. Synthesis and antibacterial evaluation of 7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzothiazine-6-carboxylic acids.
AID70947In vitro antibacterial activity against clinical isolates of Escherichia coli 15 (gram negative) by agar dilution assay.1987Journal of medicinal chemistry, Mar, Volume: 30, Issue:3
Quinolonecarboxylic acids. 2. Synthesis and antibacterial evaluation of 7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzothiazine-6-carboxylic acids.
AID96264In vitro antibacterial activity against clinical isolates of Klebsiella pneumoniae-4 (gram negative) by agar dilution assay.1987Journal of medicinal chemistry, Mar, Volume: 30, Issue:3
Quinolonecarboxylic acids. 2. Synthesis and antibacterial evaluation of 7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzothiazine-6-carboxylic acids.
AID162914In vitro antibacterial activity against clinical isolates of Proteus morganii 27 (gram negative) by agar dilution assay.1987Journal of medicinal chemistry, Mar, Volume: 30, Issue:3
Quinolonecarboxylic acids. 2. Synthesis and antibacterial evaluation of 7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzothiazine-6-carboxylic acids.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (4)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (25.00)18.7374
1990's3 (75.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceDescriptionRelationhip StrengthStudiesTrialsClassesRoles
norfloxacin[no description available]medium10fluoroquinolone antibiotic;
N-arylpiperazine;
quinolinemonocarboxylic acid;
quinolone antibiotic;
quinolone		antibacterial drug;
DNA synthesis inhibitor;
environmental contaminant;
xenobiotic
ofloxacin[no description available]medium103-oxo monocarboxylic acid;
N-arylpiperazine;
N-methylpiperazine;
organofluorine compound;
oxazinoquinoline
pipemidic acid[no description available]medium10amino acid;
monocarboxylic acid;
N-arylpiperazine;
pyridopyrimidine;
quinolone antibiotic		antibacterial drug;
DNA synthesis inhibitor
rufloxacin[no description available]medium60fluoroquinolone antibiotic;
quinolines;
quinolone antibiotic
carbostyril[no description available]medium40monohydroxyquinoline;
quinolone		bacterial xenobiotic metabolite
ConditionIndicatedRelationship StrengthStudiesTrials

Research Highlights

Pharmacokinetics (1)

ArticleYear
High-performance liquid chromatography and preliminary pharmacokinetics of rufloxacin and its metabolites, N-desmethylrufloxacin and rufloxacinsulfoxide, in urine of rhesus monkey Macaca mulatta.
Journal of chromatography, Jan-03, Volume: 573, Issue: 1		1992
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Interactions (1)

ArticleYear
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]