| Assay ID | Title | Year | Journal | Article |
|---|
| AID133761 | Maximum tolerance dose was measured for phototoxic skin reaction by po administration | 1992 | Journal of medicinal chemistry, Jan-24, Volume: 35, Issue:2
| New 8-(trifluoromethyl)-substituted quinolones. The benefits of the 8-fluoro group with reduced phototoxic risk. |
| AID201952 | In vivo efficacy (s.c.) against Streptococcus pneumoniae SV-1 in mouse protection test | 1992 | Journal of medicinal chemistry, Jan-24, Volume: 35, Issue:2
| New 8-(trifluoromethyl)-substituted quinolones. The benefits of the 8-fluoro group with reduced phototoxic risk. |
| AID151536 | Tested in vitro against Pseudomonas aeruginosa IFO3445 by agar dilution method | 1993 | Journal of medicinal chemistry, Sep-17, Volume: 36, Issue:19
| Synthesis of antimicrobial agents. 5. In vivo metabolism of 7-(4-hydroxypiperazin-1-yl)quinolones. |
| AID117654 | In vivo potency against Escherichia coli vogel using mouse protection assay when given perorally | 1988 | Journal of medicinal chemistry, May, Volume: 31, Issue:5
| Quinolone antibacterial agents. Synthesis and structure-activity relationships of 8-substituted quinoline-3-carboxylic acids and 1,8-naphthyridine-3-carboxylic acids. |
| AID163916 | Minimum inhibitory concentration (MIC) against gram negative bacteria Pseudomonas aeruginosa UI-18. | 1992 | Journal of medicinal chemistry, Jan-24, Volume: 35, Issue:2
| New 8-(trifluoromethyl)-substituted quinolones. The benefits of the 8-fluoro group with reduced phototoxic risk. |
| AID207974 | Minimum inhibitory concentration against Staphylococcus aureus H228 in vitro. | 1988 | Journal of medicinal chemistry, May, Volume: 31, Issue:5
| Quinolone antibacterial agents. Synthesis and structure-activity relationships of 8-substituted quinoline-3-carboxylic acids and 1,8-naphthyridine-3-carboxylic acids. |
| AID209462 | In vitro antibacterial activity against Streptococcus pyogenes A65 | 1990 | Journal of medicinal chemistry, Jun, Volume: 33, Issue:6
| Synthesis and structure-activity relationships of 5-substituted 6,8-difluoroquinolones, including sparfloxacin, a new quinolone antibacterial agent with improved potency. |
| AID54107 | Minimum inhibitory concentration required to inhibit DNA gyrase supercoiling. | 1991 | Journal of medicinal chemistry, Mar, Volume: 34, Issue:3
| Synthesis and biological activity of 5-alkyl-1,7,8-trisubstituted-6-fluoroquinoline-3-carboxylic acids. |
| AID117674 | Median protective dose against Escherichia coli, determined in acute, lethal systemic infection in female charles river CD-1 mice (po) | 1988 | Journal of medicinal chemistry, Mar, Volume: 31, Issue:3
| 7-substituted 5-amino-1-cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxo-3- quinolinecarboxylic acids: synthesis and biological activity of a new class of quinolone antibacterials. |
| AID209061 | In vitro antibacterial activity against Streptococcus epidermis 8 | 1990 | Journal of medicinal chemistry, Jun, Volume: 33, Issue:6
| Synthesis and structure-activity relationships of 5-substituted 6,8-difluoroquinolones, including sparfloxacin, a new quinolone antibacterial agent with improved potency. |
| AID71794 | Percentage of GABA-induced chloride currents with 10e-4 M 4-biphenylacetic acid | 1993 | Journal of medicinal chemistry, May-14, Volume: 36, Issue:10
| Quinolone antimicrobial agents substituted with morpholines at the 7-position. Syntheses and structure-activity relationships. |
| AID198020 | Antibacterial activity was determined against gram positive organism, Streptococcus faecalis (MGH-2) | 1991 | Journal of medicinal chemistry, Mar, Volume: 34, Issue:3
| Synthesis and biological activity of 5-alkyl-1,7,8-trisubstituted-6-fluoroquinoline-3-carboxylic acids. |
| AID201400 | Minimum inhibition concentration against Staphylococcus aureus MRSA strain | 1993 | Journal of medicinal chemistry, May-14, Volume: 36, Issue:10
| Quinolone antimicrobial agents substituted with morpholines at the 7-position. Syntheses and structure-activity relationships. |
| AID114066 | Oral efficacy against Pseudomonas aeruginosa 12 on Systemic Infections in Mice | 1990 | Journal of medicinal chemistry, Jun, Volume: 33, Issue:6
| Synthesis and structure-activity relationships of 5-substituted 6,8-difluoroquinolones, including sparfloxacin, a new quinolone antibacterial agent with improved potency. |
| AID117692 | The in vivo potency was determined in female charles river CD-1 mice infected with Streptococcus pyogenes after sc administration | 1991 | Journal of medicinal chemistry, Mar, Volume: 34, Issue:3
| Synthesis and biological activity of 5-amino- and 5-hydroxyquinolones, and the overwhelming influence of the remote N1-substituent in determining the structure-activity relationship. |
| AID202111 | In vivo efficacy (orally) against Streptococcus pyogenes C-203 in mouse protection test | 1992 | Journal of medicinal chemistry, Jan-24, Volume: 35, Issue:2
| New 8-(trifluoromethyl)-substituted quinolones. The benefits of the 8-fluoro group with reduced phototoxic risk. |
| AID198344 | Tested in vitro against Staphylococcus aureus IID803 by agar dilution method | 1993 | Journal of medicinal chemistry, Sep-17, Volume: 36, Issue:19
| Synthesis of antimicrobial agents. 5. In vivo metabolism of 7-(4-hydroxypiperazin-1-yl)quinolones. |
| AID117675 | Median protective dose against Escherichia coli, determined in acute, lethal systemic infection in female charles river CD-1 mice (sc) | 1988 | Journal of medicinal chemistry, Mar, Volume: 31, Issue:3
| 7-substituted 5-amino-1-cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxo-3- quinolinecarboxylic acids: synthesis and biological activity of a new class of quinolone antibacterials. |
| AID151052 | Antibacterial activity was determined against gram negative organism, Pseudomonas aeruginosa UI-18 | 1991 | Journal of medicinal chemistry, Mar, Volume: 34, Issue:3
| Synthesis and biological activity of 5-amino- and 5-hydroxyquinolones, and the overwhelming influence of the remote N1-substituent in determining the structure-activity relationship. |
| AID70290 | In vivo protection against gram-positive Escherichia coli vogel in mouse after subcutaneous administration | 1991 | Journal of medicinal chemistry, Feb, Volume: 34, Issue:2
| Quinolone antibacterials: preparation and activity of bridged bicyclic analogues of the C7-piperazine. |
| AID117660 | In vivo potency against Streptococcus pneumoniae using mouse protection assay following s.c. administration. | 1988 | Journal of medicinal chemistry, May, Volume: 31, Issue:5
| Quinolone antibacterial agents. Synthesis and structure-activity relationships of 8-substituted quinoline-3-carboxylic acids and 1,8-naphthyridine-3-carboxylic acids. |
| AID151535 | Tested in vitro against Pseudomonas aeruginosa E-2 by agar dilution method | 1993 | Journal of medicinal chemistry, Sep-17, Volume: 36, Issue:19
| Synthesis of antimicrobial agents. 5. In vivo metabolism of 7-(4-hydroxypiperazin-1-yl)quinolones. |
| AID110153 | Percentage of mice with convulsion with compound alone at 400 mg/kg | 1993 | Journal of medicinal chemistry, May-14, Volume: 36, Issue:10
| Quinolone antimicrobial agents substituted with morpholines at the 7-position. Syntheses and structure-activity relationships. |
| AID198174 | Antibacterial activity was determined against gram positive organism, Streptococcus pneumoniae (SV-1) | 1991 | Journal of medicinal chemistry, Mar, Volume: 34, Issue:3
| Synthesis and biological activity of 5-alkyl-1,7,8-trisubstituted-6-fluoroquinoline-3-carboxylic acids. |
| AID198342 | Tested in vivo against Staphylococcus aureus IID803 in mice after peroral dose of drug with 0.5% sodium carboxy methyl cellulose | 1993 | Journal of medicinal chemistry, Sep-17, Volume: 36, Issue:19
| Synthesis of antimicrobial agents. 5. In vivo metabolism of 7-(4-hydroxypiperazin-1-yl)quinolones. |
| AID202110 | In vivo efficacy (s.c.) against Streptococcus pyogenes C-203 in mouse protection test | 1992 | Journal of medicinal chemistry, Jan-24, Volume: 35, Issue:2
| New 8-(trifluoromethyl)-substituted quinolones. The benefits of the 8-fluoro group with reduced phototoxic risk. |
| AID56593 | Number of mice which show positive phototoxic reaction in 5 mice | 1992 | Journal of medicinal chemistry, Jan-24, Volume: 35, Issue:2
| New 8-(trifluoromethyl)-substituted quinolones. The benefits of the 8-fluoro group with reduced phototoxic risk. |
| AID201953 | In vivo efficacy (orally) against Streptococcus pneumoniae SV-1 in mouse protection test | 1992 | Journal of medicinal chemistry, Jan-24, Volume: 35, Issue:2
| New 8-(trifluoromethyl)-substituted quinolones. The benefits of the 8-fluoro group with reduced phototoxic risk. |
| AID93881 | Minimum inhibitory concentration against Klebsiella pneumoniae MGH-2 in vitro. | 1988 | Journal of medicinal chemistry, May, Volume: 31, Issue:5
| Quinolone antibacterial agents. Synthesis and structure-activity relationships of 8-substituted quinoline-3-carboxylic acids and 1,8-naphthyridine-3-carboxylic acids. |
| AID117652 | In vivo oral protective dose was determined in female charles river CD-1 mice infected with Escherichia coli (vogel) | 1991 | Journal of medicinal chemistry, Mar, Volume: 34, Issue:3
| Synthesis and biological activity of 5-alkyl-1,7,8-trisubstituted-6-fluoroquinoline-3-carboxylic acids. |
| AID69340 | Minimum inhibitory concentration against Escherichia coli vogel in vitro. | 1988 | Journal of medicinal chemistry, May, Volume: 31, Issue:5
| Quinolone antibacterial agents. Synthesis and structure-activity relationships of 8-substituted quinoline-3-carboxylic acids and 1,8-naphthyridine-3-carboxylic acids. |
| AID161378 | Minimum inhibitory concentration (MIC) against gram negative bacteria Prot. rettgeri M-1771. | 1992 | Journal of medicinal chemistry, Jan-24, Volume: 35, Issue:2
| New 8-(trifluoromethyl)-substituted quinolones. The benefits of the 8-fluoro group with reduced phototoxic risk. |
| AID69826 | Tested in vitro against Escherichia coli NIHJ JC-2 by agar dilution method | 1993 | Journal of medicinal chemistry, Sep-17, Volume: 36, Issue:19
| Synthesis of antimicrobial agents. 5. In vivo metabolism of 7-(4-hydroxypiperazin-1-yl)quinolones. |
| AID203167 | Tested in vitro against Serratia marcescens IAM1184 by agar dilution method | 1993 | Journal of medicinal chemistry, Sep-17, Volume: 36, Issue:19
| Synthesis of antimicrobial agents. 5. In vivo metabolism of 7-(4-hydroxypiperazin-1-yl)quinolones. |
| AID69619 | Antibacterial activity against Escherichia coli H560 | 1988 | Journal of medicinal chemistry, Mar, Volume: 31, Issue:3
| 7-substituted 5-amino-1-cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxo-3- quinolinecarboxylic acids: synthesis and biological activity of a new class of quinolone antibacterials. |
| AID117689 | The in vivo potency was determined in female charles river CD-1 mice infected with Streptococcus pneumoniae after peroral administration | 1991 | Journal of medicinal chemistry, Mar, Volume: 34, Issue:3
| Synthesis and biological activity of 5-amino- and 5-hydroxyquinolones, and the overwhelming influence of the remote N1-substituent in determining the structure-activity relationship. |
| AID117664 | In vivo subcutaneous protective dose was determined in female charles river CD-1 mice infected with Escherichia coli (vogel) | 1991 | Journal of medicinal chemistry, Mar, Volume: 34, Issue:3
| Synthesis and biological activity of 5-alkyl-1,7,8-trisubstituted-6-fluoroquinoline-3-carboxylic acids. |
| AID94133 | In vitro antibacterial activity against Klebsiella pneumoniae (A 9664) | 1989 | Journal of medicinal chemistry, Mar, Volume: 32, Issue:3
| Fluoronaphthyridines and quinolones as antibacterial agents. 1. Synthesis and structure-activity relationships of new 1-substituted derivatives. |
| AID64251 | Antibacterial activity was determined against gram negative organism, Escherichia coli vogel | 1991 | Journal of medicinal chemistry, Mar, Volume: 34, Issue:3
| Synthesis and biological activity of 5-amino- and 5-hydroxyquinolones, and the overwhelming influence of the remote N1-substituent in determining the structure-activity relationship. |
| AID69626 | Antibacterial activity against Escherichia coli Vogel | 1988 | Journal of medicinal chemistry, Mar, Volume: 31, Issue:3
| 7-substituted 5-amino-1-cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxo-3- quinolinecarboxylic acids: synthesis and biological activity of a new class of quinolone antibacterials. |
| AID117691 | The in vivo potency was determined in female charles river CD-1 mice infected with Streptococcus pyogenes after peroral administration | 1991 | Journal of medicinal chemistry, Mar, Volume: 34, Issue:3
| Synthesis and biological activity of 5-amino- and 5-hydroxyquinolones, and the overwhelming influence of the remote N1-substituent in determining the structure-activity relationship. |
| AID205946 | Minimum inhibitory concentration (MIC) against gram positive bacteria Streptococcus pyogenes C-203. | 1992 | Journal of medicinal chemistry, Jan-24, Volume: 35, Issue:2
| New 8-(trifluoromethyl)-substituted quinolones. The benefits of the 8-fluoro group with reduced phototoxic risk. |
| AID163093 | Minimum inhibitory concentration against Pseudomonas aeruginosa UI-18 in vitro. | 1988 | Journal of medicinal chemistry, May, Volume: 31, Issue:5
| Quinolone antibacterial agents. Synthesis and structure-activity relationships of 8-substituted quinoline-3-carboxylic acids and 1,8-naphthyridine-3-carboxylic acids. |
| AID198176 | Antibacterial activity was determined against gram positive organism, Streptococcus pneumoniae SV-1 | 1991 | Journal of medicinal chemistry, Mar, Volume: 34, Issue:3
| Synthesis and biological activity of 5-amino- and 5-hydroxyquinolones, and the overwhelming influence of the remote N1-substituent in determining the structure-activity relationship. |
| AID103832 | In vitro antibacterial activity against Morganella morganii (A 15153) | 1989 | Journal of medicinal chemistry, Mar, Volume: 32, Issue:3
| Fluoronaphthyridines and quinolones as antibacterial agents. 1. Synthesis and structure-activity relationships of new 1-substituted derivatives. |
| AID205944 | Minimum inhibitory concentration (MIC) against gram positive bacteria Streptococcus faecalis MGH-2. | 1992 | Journal of medicinal chemistry, Jan-24, Volume: 35, Issue:2
| New 8-(trifluoromethyl)-substituted quinolones. The benefits of the 8-fluoro group with reduced phototoxic risk. |
| AID150908 | Antibacterial activity was determined against gram negative organism, Pseudomonas aeruginosa (UI-18) | 1991 | Journal of medicinal chemistry, Mar, Volume: 34, Issue:3
| Synthesis and biological activity of 5-alkyl-1,7,8-trisubstituted-6-fluoroquinoline-3-carboxylic acids. |
| AID209126 | Antibacterial activity against Streptococcus pyogenes C203 | 1988 | Journal of medicinal chemistry, Mar, Volume: 31, Issue:3
| 7-substituted 5-amino-1-cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxo-3- quinolinecarboxylic acids: synthesis and biological activity of a new class of quinolone antibacterials. |
| AID198316 | Antibacterial activity was determined against gram positive organism, Streptococcus pyogenes (C203) | 1991 | Journal of medicinal chemistry, Mar, Volume: 34, Issue:3
| Synthesis and biological activity of 5-alkyl-1,7,8-trisubstituted-6-fluoroquinoline-3-carboxylic acids. |
| AID151055 | In vitro antibacterial activity against Pseudomonas aeruginosa (A 9843) | 1989 | Journal of medicinal chemistry, Mar, Volume: 32, Issue:3
| Fluoronaphthyridines and quinolones as antibacterial agents. 1. Synthesis and structure-activity relationships of new 1-substituted derivatives. |
| AID209247 | Minimum inhibitory concentration against Streptococcus faecalis MGH-2 in vitro. | 1988 | Journal of medicinal chemistry, May, Volume: 31, Issue:5
| Quinolone antibacterial agents. Synthesis and structure-activity relationships of 8-substituted quinoline-3-carboxylic acids and 1,8-naphthyridine-3-carboxylic acids. |
| AID200230 | Antibacterial activity was determined against gram positive organism, Staphylococcus aureus (H228) | 1991 | Journal of medicinal chemistry, Mar, Volume: 34, Issue:3
| Synthesis and biological activity of 5-alkyl-1,7,8-trisubstituted-6-fluoroquinoline-3-carboxylic acids. |
| AID230838 | MIC ratio measured as the mean MICs of gram-negative bacteria | 1991 | Journal of medicinal chemistry, Mar, Volume: 34, Issue:3
| Synthesis and biological activity of 5-alkyl-1,7,8-trisubstituted-6-fluoroquinoline-3-carboxylic acids. |
| AID74734 | MIC ratio measured as the mean MICs of gram-positive bacteria | 1991 | Journal of medicinal chemistry, Mar, Volume: 34, Issue:3
| Synthesis and biological activity of 5-amino- and 5-hydroxyquinolones, and the overwhelming influence of the remote N1-substituent in determining the structure-activity relationship. |
| AID202106 | Minimum inhibition concentration against Streptococcus pneumoniae Type I strain | 1993 | Journal of medicinal chemistry, May-14, Volume: 36, Issue:10
| Quinolone antimicrobial agents substituted with morpholines at the 7-position. Syntheses and structure-activity relationships. |
| AID74856 | Compound evaluated in vitro against five gram-positive bacterial strains and geometric means of the minimum inhibitory concentrations (MIC) reported. | 1991 | Journal of medicinal chemistry, Feb, Volume: 34, Issue:2
| Quinolone antibacterials: preparation and activity of bridged bicyclic analogues of the C7-piperazine. |
| AID71793 | Percentage of GABA-induced chloride currents with 10 e-5 M 4-biphenylacetic acid | 1993 | Journal of medicinal chemistry, May-14, Volume: 36, Issue:10
| Quinolone antimicrobial agents substituted with morpholines at the 7-position. Syntheses and structure-activity relationships. |
| AID163914 | In vivo efficacy (s.c.) against Pseudomonas aeruginosa in mouse protection test | 1992 | Journal of medicinal chemistry, Jan-24, Volume: 35, Issue:2
| New 8-(trifluoromethyl)-substituted quinolones. The benefits of the 8-fluoro group with reduced phototoxic risk. |
| AID198317 | Antibacterial activity was determined against gram positive organism, Streptococcus pyogenes C203 | 1991 | Journal of medicinal chemistry, Mar, Volume: 34, Issue:3
| Synthesis and biological activity of 5-amino- and 5-hydroxyquinolones, and the overwhelming influence of the remote N1-substituent in determining the structure-activity relationship. |
| AID57388 | Minimum inhibitory concentration against Escherichia coli DNA-gyrase in supercoiling assay | 1991 | Journal of medicinal chemistry, Mar, Volume: 34, Issue:3
| Synthesis and biological activity of 5-amino- and 5-hydroxyquinolones, and the overwhelming influence of the remote N1-substituent in determining the structure-activity relationship. |
| AID63899 | Antibacterial activity against gram negative organism, Escherichia cloacae (MA2646) | 1991 | Journal of medicinal chemistry, Mar, Volume: 34, Issue:3
| Synthesis and biological activity of 5-alkyl-1,7,8-trisubstituted-6-fluoroquinoline-3-carboxylic acids. |
| AID68191 | In vitro antibacterial activity against Enterobacter cloacae 963 | 1990 | Journal of medicinal chemistry, Jun, Volume: 33, Issue:6
| Synthesis and structure-activity relationships of 5-substituted 6,8-difluoroquinolones, including sparfloxacin, a new quinolone antibacterial agent with improved potency. |
| AID117665 | In vivo subcutaneous protective dose was determined in female charles river CD-1 mice infected with Streptococcus pneumoniae | 1991 | Journal of medicinal chemistry, Mar, Volume: 34, Issue:3
| Synthesis and biological activity of 5-alkyl-1,7,8-trisubstituted-6-fluoroquinoline-3-carboxylic acids. |
| AID163915 | In vivo efficacy (orally) against Pseudomonas aeruginosa in mouse protection test | 1992 | Journal of medicinal chemistry, Jan-24, Volume: 35, Issue:2
| New 8-(trifluoromethyl)-substituted quinolones. The benefits of the 8-fluoro group with reduced phototoxic risk. |
| AID200881 | Tested in vitro against Salmonella Typhimurium IID971 by agar dilution method | 1993 | Journal of medicinal chemistry, Sep-17, Volume: 36, Issue:19
| Synthesis of antimicrobial agents. 5. In vivo metabolism of 7-(4-hydroxypiperazin-1-yl)quinolones. |
| AID94123 | Antibacterial activity was determined against gram negative organism, K. pneumoniae (MGH-2) | 1991 | Journal of medicinal chemistry, Mar, Volume: 34, Issue:3
| Synthesis and biological activity of 5-alkyl-1,7,8-trisubstituted-6-fluoroquinoline-3-carboxylic acids. |
| AID163554 | Tested in vitro against Proteus vulgaris OX-19 by agar dilution method | 1993 | Journal of medicinal chemistry, Sep-17, Volume: 36, Issue:19
| Synthesis of antimicrobial agents. 5. In vivo metabolism of 7-(4-hydroxypiperazin-1-yl)quinolones. |
| AID71980 | Inhibition of [3H]muscimol binding to GABA A receptor 4-biphenylacetic acid at 10 e-4 M | 1993 | Journal of medicinal chemistry, May-14, Volume: 36, Issue:10
| Quinolone antimicrobial agents substituted with morpholines at the 7-position. Syntheses and structure-activity relationships. |
| AID68013 | Antibacterial activity against Enterobacter cloacae MA2646 | 1988 | Journal of medicinal chemistry, Mar, Volume: 31, Issue:3
| 7-substituted 5-amino-1-cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxo-3- quinolinecarboxylic acids: synthesis and biological activity of a new class of quinolone antibacterials. |
| AID96403 | In vitro antibacterial activity against gram-negative Klebsiella pneumoniae | 2004 | Bioorganic & medicinal chemistry letters, Jan-19, Volume: 14, Issue:2
| Synthesis and antibacterial activity of 7-(substituted)aminomethyl quinolones. |
| AID114068 | Oral efficacy against Streptococcus pyogenes A65 on Systemic Infections in Mice | 1990 | Journal of medicinal chemistry, Jun, Volume: 33, Issue:6
| Synthesis and structure-activity relationships of 5-substituted 6,8-difluoroquinolones, including sparfloxacin, a new quinolone antibacterial agent with improved potency. |
| AID64405 | The in vivo potency was determined in female charles river CD-1 mice infected with Escherichia coli after sc administration | 1991 | Journal of medicinal chemistry, Mar, Volume: 34, Issue:3
| Synthesis and biological activity of 5-amino- and 5-hydroxyquinolones, and the overwhelming influence of the remote N1-substituent in determining the structure-activity relationship. |
| AID70704 | Minimum inhibitory concentration (MIC) against gram negative bacteria Escherichia coli H-560. | 1992 | Journal of medicinal chemistry, Jan-24, Volume: 35, Issue:2
| New 8-(trifluoromethyl)-substituted quinolones. The benefits of the 8-fluoro group with reduced phototoxic risk. |
| AID69339 | Minimum inhibitory concentration against Escherichia coli H560 in vitro. | 1988 | Journal of medicinal chemistry, May, Volume: 31, Issue:5
| Quinolone antibacterial agents. Synthesis and structure-activity relationships of 8-substituted quinoline-3-carboxylic acids and 1,8-naphthyridine-3-carboxylic acids. |
| AID68519 | Minimum inhibitory concentration against Enterobacter cloacae HA 2646 in vitro. | 1988 | Journal of medicinal chemistry, May, Volume: 31, Issue:5
| Quinolone antibacterial agents. Synthesis and structure-activity relationships of 8-substituted quinoline-3-carboxylic acids and 1,8-naphthyridine-3-carboxylic acids. |
| AID117657 | In vivo potency against Staphylococcus aureus using mouse protection assay following s.c. administration. | 1988 | Journal of medicinal chemistry, May, Volume: 31, Issue:5
| Quinolone antibacterial agents. Synthesis and structure-activity relationships of 8-substituted quinoline-3-carboxylic acids and 1,8-naphthyridine-3-carboxylic acids. |
| AID65384 | Minimum inhibition concentration against Enterococcus faecalis LS-101 strain | 1993 | Journal of medicinal chemistry, May-14, Volume: 36, Issue:10
| Quinolone antimicrobial agents substituted with morpholines at the 7-position. Syntheses and structure-activity relationships. |
| AID203326 | In vitro antibacterial activity against Serratia marcescens S-9 | 1990 | Journal of medicinal chemistry, Jun, Volume: 33, Issue:6
| Synthesis and structure-activity relationships of 5-substituted 6,8-difluoroquinolones, including sparfloxacin, a new quinolone antibacterial agent with improved potency. |
| AID209067 | Antibacterial activity against Streptococcus faecalis MGH-2 | 1988 | Journal of medicinal chemistry, Mar, Volume: 31, Issue:3
| 7-substituted 5-amino-1-cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxo-3- quinolinecarboxylic acids: synthesis and biological activity of a new class of quinolone antibacterials. |
| AID95531 | Minimum inhibitory concentration (MIC) against gram negative bacteria Klebsiella pneumoniae MGH-2. | 1992 | Journal of medicinal chemistry, Jan-24, Volume: 35, Issue:2
| New 8-(trifluoromethyl)-substituted quinolones. The benefits of the 8-fluoro group with reduced phototoxic risk. |
| AID70705 | Minimum inhibitory concentration (MIC) against gram negative bacteria Escherichia coli Vogel. | 1992 | Journal of medicinal chemistry, Jan-24, Volume: 35, Issue:2
| New 8-(trifluoromethyl)-substituted quinolones. The benefits of the 8-fluoro group with reduced phototoxic risk. |
| AID64394 | In vitro antibacterial activity against Enterobacter cloacae (A 9656) | 1989 | Journal of medicinal chemistry, Mar, Volume: 32, Issue:3
| Fluoronaphthyridines and quinolones as antibacterial agents. 1. Synthesis and structure-activity relationships of new 1-substituted derivatives. |
| AID64076 | In vitro antibacterial activity against Escherichia coli (A 15119) | 1989 | Journal of medicinal chemistry, Mar, Volume: 32, Issue:3
| Fluoronaphthyridines and quinolones as antibacterial agents. 1. Synthesis and structure-activity relationships of new 1-substituted derivatives. |
| AID203042 | In vitro antibacterial activity against gram-negative Shigella boydii | 2004 | Bioorganic & medicinal chemistry letters, Jan-19, Volume: 14, Issue:2
| Synthesis and antibacterial activity of 7-(substituted)aminomethyl quinolones. |
| AID117690 | The in vivo potency was determined in female charles river CD-1 mice infected with Streptococcus pneumoniae after sc administration | 1991 | Journal of medicinal chemistry, Mar, Volume: 34, Issue:3
| Synthesis and biological activity of 5-amino- and 5-hydroxyquinolones, and the overwhelming influence of the remote N1-substituent in determining the structure-activity relationship. |
| AID206034 | Tested in vitro against Staphylococcus epidermidis IAM12896 by agar dilution method | 1993 | Journal of medicinal chemistry, Sep-17, Volume: 36, Issue:19
| Synthesis of antimicrobial agents. 5. In vivo metabolism of 7-(4-hydroxypiperazin-1-yl)quinolones. |
| AID198021 | Antibacterial activity was determined against gram positive organism, Streptococcus faecalis MGH-2 | 1991 | Journal of medicinal chemistry, Mar, Volume: 34, Issue:3
| Synthesis and biological activity of 5-amino- and 5-hydroxyquinolones, and the overwhelming influence of the remote N1-substituent in determining the structure-activity relationship. |
| AID206600 | In vitro antibacterial activity against gram-positive Staphylococcus aureus | 2004 | Bioorganic & medicinal chemistry letters, Jan-19, Volume: 14, Issue:2
| Synthesis and antibacterial activity of 7-(substituted)aminomethyl quinolones. |
| AID198343 | Tested in vitro against Staphylococcus aureus FDA209P JC-1 by agar dilution method | 1993 | Journal of medicinal chemistry, Sep-17, Volume: 36, Issue:19
| Synthesis of antimicrobial agents. 5. In vivo metabolism of 7-(4-hydroxypiperazin-1-yl)quinolones. |
| AID210380 | In vitro antibacterial activity against gram-positive Streptococcus pneumoniae | 2004 | Bioorganic & medicinal chemistry letters, Jan-19, Volume: 14, Issue:2
| Synthesis and antibacterial activity of 7-(substituted)aminomethyl quinolones. |
| AID63898 | Antibacterial activity was determined against gram negative organism, Enterobacter cloacae MA2646 | 1991 | Journal of medicinal chemistry, Mar, Volume: 34, Issue:3
| Synthesis and biological activity of 5-amino- and 5-hydroxyquinolones, and the overwhelming influence of the remote N1-substituent in determining the structure-activity relationship. |
| AID69048 | Minimum concentration needed to produce linear DNA at an intensity relative to oxolinic at 10 ug/mL in Escherichia coli H560 in vitro. | 1988 | Journal of medicinal chemistry, May, Volume: 31, Issue:5
| Quinolone antibacterial agents. Synthesis and structure-activity relationships of 8-substituted quinoline-3-carboxylic acids and 1,8-naphthyridine-3-carboxylic acids. |
| AID65221 | Minimum inhibition concentration against Escherichia coli NIHJ JC-2 strain | 1993 | Journal of medicinal chemistry, May-14, Volume: 36, Issue:10
| Quinolone antimicrobial agents substituted with morpholines at the 7-position. Syntheses and structure-activity relationships. |
| AID52945 | In vitro antibacterial activity against gram-negative Citrobacter freundii | 2004 | Bioorganic & medicinal chemistry letters, Jan-19, Volume: 14, Issue:2
| Synthesis and antibacterial activity of 7-(substituted)aminomethyl quinolones. |
| AID64254 | Antibacterial activity was determined against gram negative organism, E. coli(vogel) | 1991 | Journal of medicinal chemistry, Mar, Volume: 34, Issue:3
| Synthesis and biological activity of 5-alkyl-1,7,8-trisubstituted-6-fluoroquinoline-3-carboxylic acids. |
| AID51918 | Mammalian cell cytotoxicity test in chinese hamster V79 cells (clonogenic cytotoxicity) | 1992 | Journal of medicinal chemistry, Dec-11, Volume: 35, Issue:25
| Fluoroquinolones: relationships between structural variations, mammalian cell cytotoxicity, and antimicrobial activity. |
| AID71795 | Percentage of GABA-induced chloride currents with compound alone at 10 e-4 M | 1993 | Journal of medicinal chemistry, May-14, Volume: 36, Issue:10
| Quinolone antimicrobial agents substituted with morpholines at the 7-position. Syntheses and structure-activity relationships. |
| AID197875 | Minimum inhibition concentration against Staphylococcus aureus FDA209P strain | 1993 | Journal of medicinal chemistry, May-14, Volume: 36, Issue:10
| Quinolone antimicrobial agents substituted with morpholines at the 7-position. Syntheses and structure-activity relationships. |
| AID64404 | The in vivo potency was determined in female charles river CD-1 mice infected with Escherichia coli after peroral administration | 1991 | Journal of medicinal chemistry, Mar, Volume: 34, Issue:3
| Synthesis and biological activity of 5-amino- and 5-hydroxyquinolones, and the overwhelming influence of the remote N1-substituent in determining the structure-activity relationship. |
| AID205945 | Minimum inhibitory concentration (MIC) against gram positive bacteria Streptococcus pneumoniae SV-1. | 1992 | Journal of medicinal chemistry, Jan-24, Volume: 35, Issue:2
| New 8-(trifluoromethyl)-substituted quinolones. The benefits of the 8-fluoro group with reduced phototoxic risk. |
| AID151373 | Antibacterial activity was determined against gram negative organism, Providencia rettgeri. (M1771) | 1991 | Journal of medicinal chemistry, Mar, Volume: 34, Issue:3
| Synthesis and biological activity of 5-alkyl-1,7,8-trisubstituted-6-fluoroquinoline-3-carboxylic acids. |
| AID206890 | Antibacterial activity against Staphylococcus aureus UC76 | 1988 | Journal of medicinal chemistry, Mar, Volume: 31, Issue:3
| 7-substituted 5-amino-1-cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxo-3- quinolinecarboxylic acids: synthesis and biological activity of a new class of quinolone antibacterials. |
| AID117659 | In vivo potency against Streptococcus pneumoniae using mouse protection assay following p.o. administration. | 1988 | Journal of medicinal chemistry, May, Volume: 31, Issue:5
| Quinolone antibacterial agents. Synthesis and structure-activity relationships of 8-substituted quinoline-3-carboxylic acids and 1,8-naphthyridine-3-carboxylic acids. |
| AID207975 | Minimum inhibitory concentration against Staphylococcus aureus UC-76 in vitro. | 1988 | Journal of medicinal chemistry, May, Volume: 31, Issue:5
| Quinolone antibacterial agents. Synthesis and structure-activity relationships of 8-substituted quinoline-3-carboxylic acids and 1,8-naphthyridine-3-carboxylic acids. |
| AID74729 | Compound evaluated in vitro against five gram-negative bacterial strains and geometric means of the minimum inhibitory concentrations (MIC) reported. | 1991 | Journal of medicinal chemistry, Feb, Volume: 34, Issue:2
| Quinolone antibacterials: preparation and activity of bridged bicyclic analogues of the C7-piperazine. |
| AID96249 | In vitro antibacterial activity against Klebsiella pneumoniae 13 | 1990 | Journal of medicinal chemistry, Jun, Volume: 33, Issue:6
| Synthesis and structure-activity relationships of 5-substituted 6,8-difluoroquinolones, including sparfloxacin, a new quinolone antibacterial agent with improved potency. |
| AID67532 | Minimum inhibitory concentration (MIC) against gram negative bacteria Enterobacter cloacae MA-2646. | 1992 | Journal of medicinal chemistry, Jan-24, Volume: 35, Issue:2
| New 8-(trifluoromethyl)-substituted quinolones. The benefits of the 8-fluoro group with reduced phototoxic risk. |
| AID197880 | In vitro antibacterial activity against Staphylococcus aureus Smith (A9537) | 1989 | Journal of medicinal chemistry, Mar, Volume: 32, Issue:3
| Fluoronaphthyridines and quinolones as antibacterial agents. 1. Synthesis and structure-activity relationships of new 1-substituted derivatives. |
| AID95916 | Antibacterial activity against Klebsiella pneumoniae MGH-2 | 1988 | Journal of medicinal chemistry, Mar, Volume: 31, Issue:3
| 7-substituted 5-amino-1-cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxo-3- quinolinecarboxylic acids: synthesis and biological activity of a new class of quinolone antibacterials. |
| AID94051 | Tested in vitro against Klebsiella pneumoniae PCI-602 by agar dilution method | 1993 | Journal of medicinal chemistry, Sep-17, Volume: 36, Issue:19
| Synthesis of antimicrobial agents. 5. In vivo metabolism of 7-(4-hydroxypiperazin-1-yl)quinolones. |
| AID165048 | In vitro antibacterial activity against Pseudomonas aeruginosa IFO 3445 | 1990 | Journal of medicinal chemistry, Jun, Volume: 33, Issue:6
| Synthesis and structure-activity relationships of 5-substituted 6,8-difluoroquinolones, including sparfloxacin, a new quinolone antibacterial agent with improved potency. |
| AID53313 | Compound evaluated in vitro for the ability to inhibit gyrase. | 1991 | Journal of medicinal chemistry, Feb, Volume: 34, Issue:2
| Quinolone antibacterials: preparation and activity of bridged bicyclic analogues of the C7-piperazine. |
| AID203106 | Minimum inhibitory concentration (MIC) against gram positive bacteria Staphylococcus aureus H-228. | 1992 | Journal of medicinal chemistry, Jan-24, Volume: 35, Issue:2
| New 8-(trifluoromethyl)-substituted quinolones. The benefits of the 8-fluoro group with reduced phototoxic risk. |
| AID117859 | Dose required to induce phototoxic reaction in 50% of mice by prolit reactions at different dosage forms | 1992 | Journal of medicinal chemistry, Jan-24, Volume: 35, Issue:2
| New 8-(trifluoromethyl)-substituted quinolones. The benefits of the 8-fluoro group with reduced phototoxic risk. |
| AID206877 | Antibacterial activity against Staphylococcus aureus H-228 | 1988 | Journal of medicinal chemistry, Mar, Volume: 31, Issue:3
| 7-substituted 5-amino-1-cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxo-3- quinolinecarboxylic acids: synthesis and biological activity of a new class of quinolone antibacterials. |
| AID208766 | In vivo protection against gram-positive Streptococcus pneumonia (SV-1) in mouse after oral administration. | 1991 | Journal of medicinal chemistry, Feb, Volume: 34, Issue:2
| Quinolone antibacterials: preparation and activity of bridged bicyclic analogues of the C7-piperazine. |
| AID209225 | In vitro antibacterial activity against Streptococcus faecalis 2473 | 1990 | Journal of medicinal chemistry, Jun, Volume: 33, Issue:6
| Synthesis and structure-activity relationships of 5-substituted 6,8-difluoroquinolones, including sparfloxacin, a new quinolone antibacterial agent with improved potency. |
| AID164245 | Antibacterial activity against Pseudomonas aeruginosa UI-18 | 1988 | Journal of medicinal chemistry, Mar, Volume: 31, Issue:3
| 7-substituted 5-amino-1-cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxo-3- quinolinecarboxylic acids: synthesis and biological activity of a new class of quinolone antibacterials. |
| AID110152 | Percentage of mice with convulsion (400 mg/kg fenbufen) | 1993 | Journal of medicinal chemistry, May-14, Volume: 36, Issue:10
| Quinolone antimicrobial agents substituted with morpholines at the 7-position. Syntheses and structure-activity relationships. |
| AID151374 | Antibacterial activity was determined against gram negative organism, Providencia rettgeri. M1771 | 1991 | Journal of medicinal chemistry, Mar, Volume: 34, Issue:3
| Synthesis and biological activity of 5-amino- and 5-hydroxyquinolones, and the overwhelming influence of the remote N1-substituent in determining the structure-activity relationship. |
| AID151670 | Minimum inhibition concentration against Pseudomonas aeruginosa U-31 strain | 1993 | Journal of medicinal chemistry, May-14, Volume: 36, Issue:10
| Quinolone antimicrobial agents substituted with morpholines at the 7-position. Syntheses and structure-activity relationships. |
| AID151530 | Tested in vivo against Pseudomonas aeruginosa E-2 in mice after peroral dose of drug with 0.5% sodium carboxy methyl cellulose | 1993 | Journal of medicinal chemistry, Sep-17, Volume: 36, Issue:19
| Synthesis of antimicrobial agents. 5. In vivo metabolism of 7-(4-hydroxypiperazin-1-yl)quinolones. |
| AID70926 | In vitro antibacterial activity against Escherichia coli P-5101 | 1990 | Journal of medicinal chemistry, Jun, Volume: 33, Issue:6
| Synthesis and structure-activity relationships of 5-substituted 6,8-difluoroquinolones, including sparfloxacin, a new quinolone antibacterial agent with improved potency. |
| AID208301 | Minimum inhibitory concentration against Streptococcus pneumoniae SV-1 in vitro. | 1988 | Journal of medicinal chemistry, May, Volume: 31, Issue:5
| Quinolone antibacterial agents. Synthesis and structure-activity relationships of 8-substituted quinoline-3-carboxylic acids and 1,8-naphthyridine-3-carboxylic acids. |
| AID209894 | Antibacterial activity against Streptococcus pneumoniae SV-1 | 1988 | Journal of medicinal chemistry, Mar, Volume: 31, Issue:3
| 7-substituted 5-amino-1-cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxo-3- quinolinecarboxylic acids: synthesis and biological activity of a new class of quinolone antibacterials. |
| AID197877 | Antibacterial activity was determined against gram positive organism, Staphylococcus aureus H228 | 1991 | Journal of medicinal chemistry, Mar, Volume: 34, Issue:3
| Synthesis and biological activity of 5-amino- and 5-hydroxyquinolones, and the overwhelming influence of the remote N1-substituent in determining the structure-activity relationship. |
| AID209759 | Minimum inhibitory concentration against Streptococcus pyogenes C203 in vitro. | 1988 | Journal of medicinal chemistry, May, Volume: 31, Issue:5
| Quinolone antibacterial agents. Synthesis and structure-activity relationships of 8-substituted quinoline-3-carboxylic acids and 1,8-naphthyridine-3-carboxylic acids. |
| AID74723 | MIC ratio measured as the mean MICs of gram-negative bacteria | 1991 | Journal of medicinal chemistry, Mar, Volume: 34, Issue:3
| Synthesis and biological activity of 5-amino- and 5-hydroxyquinolones, and the overwhelming influence of the remote N1-substituent in determining the structure-activity relationship. |
| AID117655 | In vivo potency against Escherichia coli vogel using mouse protection assay when given subcutaneously | 1988 | Journal of medicinal chemistry, May, Volume: 31, Issue:5
| Quinolone antibacterial agents. Synthesis and structure-activity relationships of 8-substituted quinoline-3-carboxylic acids and 1,8-naphthyridine-3-carboxylic acids. |
| AID127505 | In vitro antibacterial activity against glucose nonfermenter Moraxella bovis P-7101 | 1990 | Journal of medicinal chemistry, Jun, Volume: 33, Issue:6
| Synthesis and structure-activity relationships of 5-substituted 6,8-difluoroquinolones, including sparfloxacin, a new quinolone antibacterial agent with improved potency. |
| AID208767 | In vivo protection against gram-positive Streptococcus pneumonia (SV-1) in mouse after subcutaneous administration | 1991 | Journal of medicinal chemistry, Feb, Volume: 34, Issue:2
| Quinolone antibacterials: preparation and activity of bridged bicyclic analogues of the C7-piperazine. |
| AID163732 | Antibacterial activity against Providencia rettgeri M1771 | 1988 | Journal of medicinal chemistry, Mar, Volume: 31, Issue:3
| 7-substituted 5-amino-1-cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxo-3- quinolinecarboxylic acids: synthesis and biological activity of a new class of quinolone antibacterials. |
| AID78692 | 50% inhibitory concentration against DNA-gyrase | 1988 | Journal of medicinal chemistry, Mar, Volume: 31, Issue:3
| 7-substituted 5-amino-1-cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxo-3- quinolinecarboxylic acids: synthesis and biological activity of a new class of quinolone antibacterials. |
| AID117656 | In vivo potency against Staphylococcus aureus using mouse protection assay following p.o. administration. | 1988 | Journal of medicinal chemistry, May, Volume: 31, Issue:5
| Quinolone antibacterial agents. Synthesis and structure-activity relationships of 8-substituted quinoline-3-carboxylic acids and 1,8-naphthyridine-3-carboxylic acids. |
| AID122563 | Dose which has no effect to induce phototoxic reaction in 50% of mice by probit method. | 1992 | Journal of medicinal chemistry, Jan-24, Volume: 35, Issue:2
| New 8-(trifluoromethyl)-substituted quinolones. The benefits of the 8-fluoro group with reduced phototoxic risk. |
| AID165035 | In vitro antibacterial activity against Pseudomonas aeruginosa 12 | 1990 | Journal of medicinal chemistry, Jun, Volume: 33, Issue:6
| Synthesis and structure-activity relationships of 5-substituted 6,8-difluoroquinolones, including sparfloxacin, a new quinolone antibacterial agent with improved potency. |
| AID70289 | In vivo protection against gram-positive Escherichia coli vogel in mouse after oral administration. | 1991 | Journal of medicinal chemistry, Feb, Volume: 34, Issue:2
| Quinolone antibacterials: preparation and activity of bridged bicyclic analogues of the C7-piperazine. |
| AID94001 | Antibacterial activity was determined against gram negative organism, Klebsiella pneumoniae MGH-2 | 1991 | Journal of medicinal chemistry, Mar, Volume: 34, Issue:3
| Synthesis and biological activity of 5-amino- and 5-hydroxyquinolones, and the overwhelming influence of the remote N1-substituent in determining the structure-activity relationship. |
| AID71070 | Concentration required to produce linear DNA from closed circular DNA by the denaturation of the drug-gyrase-DNA complex | 1988 | Journal of medicinal chemistry, Mar, Volume: 31, Issue:3
| 7-substituted 5-amino-1-cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxo-3- quinolinecarboxylic acids: synthesis and biological activity of a new class of quinolone antibacterials. |
| AID40925 | Tested in vitro against Bacillus subtilis ATCC 6633 by agar dilution method | 1993 | Journal of medicinal chemistry, Sep-17, Volume: 36, Issue:19
| Synthesis of antimicrobial agents. 5. In vivo metabolism of 7-(4-hydroxypiperazin-1-yl)quinolones. |
| AID200231 | Antibacterial activity was determined against gram positive organism, Staphylococcus aureus (UC76) | 1991 | Journal of medicinal chemistry, Mar, Volume: 34, Issue:3
| Synthesis and biological activity of 5-alkyl-1,7,8-trisubstituted-6-fluoroquinoline-3-carboxylic acids. |
| AID65234 | In vivo efficacy in mouse protection test in Escherichia coli Vogel administered by subcutaneous injection. | 1992 | Journal of medicinal chemistry, Jan-24, Volume: 35, Issue:2
| New 8-(trifluoromethyl)-substituted quinolones. The benefits of the 8-fluoro group with reduced phototoxic risk. |
| AID74853 | Antibacterial activity against five Gram-positive bacteria targeting topoisomerase II (DNA gyrase B GyrB) | 1992 | Journal of medicinal chemistry, Dec-11, Volume: 35, Issue:25
| Fluoroquinolones: relationships between structural variations, mammalian cell cytotoxicity, and antimicrobial activity. |
| AID197882 | Antibacterial activity was determined against gram positive organism, Staphylococcus aureus UC76 | 1991 | Journal of medicinal chemistry, Mar, Volume: 34, Issue:3
| Synthesis and biological activity of 5-amino- and 5-hydroxyquinolones, and the overwhelming influence of the remote N1-substituent in determining the structure-activity relationship. |
| AID205745 | In vitro antibacterial activity against gram-positive Staphylococcus epidermidis | 2004 | Bioorganic & medicinal chemistry letters, Jan-19, Volume: 14, Issue:2
| Synthesis and antibacterial activity of 7-(substituted)aminomethyl quinolones. |
| AID56590 | Days of the first positive reaction in depleted mice | 1992 | Journal of medicinal chemistry, Jan-24, Volume: 35, Issue:2
| New 8-(trifluoromethyl)-substituted quinolones. The benefits of the 8-fluoro group with reduced phototoxic risk. |
| AID71981 | Inhibition of [3H]muscimol binding to GABA A receptor with compound alone at 10 e-4 M | 1993 | Journal of medicinal chemistry, May-14, Volume: 36, Issue:10
| Quinolone antimicrobial agents substituted with morpholines at the 7-position. Syntheses and structure-activity relationships. |
| AID74727 | Antibacterial activity against five Gram-negative bacteria | 1992 | Journal of medicinal chemistry, Dec-11, Volume: 35, Issue:25
| Fluoroquinolones: relationships between structural variations, mammalian cell cytotoxicity, and antimicrobial activity. |
| AID65235 | In vivo efficacy in mouse protection test in Escherichia coli Vogel dose administered orally by gavage. | 1992 | Journal of medicinal chemistry, Jan-24, Volume: 35, Issue:2
| New 8-(trifluoromethyl)-substituted quinolones. The benefits of the 8-fluoro group with reduced phototoxic risk. |
| AID203107 | Minimum inhibitory concentration (MIC) against gram positive bacteria Staphylococcus aureus UC-76. | 1992 | Journal of medicinal chemistry, Jan-24, Volume: 35, Issue:2
| New 8-(trifluoromethyl)-substituted quinolones. The benefits of the 8-fluoro group with reduced phototoxic risk. |
| AID206284 | In vitro antibacterial activity against Staphylococcus aureus 50774 | 1990 | Journal of medicinal chemistry, Jun, Volume: 33, Issue:6
| Synthesis and structure-activity relationships of 5-substituted 6,8-difluoroquinolones, including sparfloxacin, a new quinolone antibacterial agent with improved potency. |
| AID163051 | Minimum inhibitory concentration against Providencia rettgeri H1771 in vitro. | 1988 | Journal of medicinal chemistry, May, Volume: 31, Issue:5
| Quinolone antibacterial agents. Synthesis and structure-activity relationships of 8-substituted quinoline-3-carboxylic acids and 1,8-naphthyridine-3-carboxylic acids. |
| AID117653 | In vivo oral protective dose was determined in female charles river CD-1 mice infected with Streptococcus pneumoniae | 1991 | Journal of medicinal chemistry, Mar, Volume: 34, Issue:3
| Synthesis and biological activity of 5-alkyl-1,7,8-trisubstituted-6-fluoroquinoline-3-carboxylic acids. |
| AID230840 | MIC ratio measured as the mean MICs of gram-positive bacteria | 1991 | Journal of medicinal chemistry, Mar, Volume: 34, Issue:3
| Synthesis and biological activity of 5-alkyl-1,7,8-trisubstituted-6-fluoroquinoline-3-carboxylic acids. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |