vexibinol profile

vexibinol: flavanol from Sophora; structure in first source; RN given refers to (S-(R*,S*))-isomer [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

sophoraflavanone G : A tetrahydroxyflavanone having a structure of naringenin bearing an additional hydroxyl substituent at position 2' as well as a (2R)-5-methyl-2-(prop-1-en-2-yl)hex-4-en-1-yl (lavandulyl) substituent at position 8'. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

ID Source	ID
PubMed CID	72936
CHEMBL ID	243148
CHEBI ID	50209
SCHEMBL ID	2228023
MeSH ID	M0178512

Synonym
sophoraflavanone g
vexibinol
4h-1-benzopyran-4-one, 2,3-dihydro-5,7-dihydroxy-2-(2,4-dihydroxyphenyl)-8-(5-methyl-2-(1-methylethenyl)-4-hexenyl)-, (s-(r,s))-
CHEBI:50209 ,
(2s)-2-(2,4-dihydroxyphenyl)-5,7-dihydroxy-8-[(2r)-5-methyl-2-(prop-1-en-2-yl)hex-4-en-1-yl]-2,3-dihydro-4h-chromen-4-one
(2s)-5,7,2',4'-tetrahydroxy-8-lavandulylflavanone
97938-30-2
CHEMBL243148 ,
(2s)-2-(2,4-dihydroxyphenyl)-5,7-dihydroxy-8-[(2r)-5-methyl-2-prop-1-en-2-ylhex-4-enyl]-2,3-dihydrochromen-4-one
bdbm50208611
(-)-vexibinol
norkurarinone
5,7,2',4'-tetrahydroxy-8-lavandulyl-flavanone
kushnol f
SCHEMBL2228023
AC-34326
DTXSID10243345
2',4',5,7-tetrahydroxy-6-lavandulylflavanone
AKOS032948438
HY-N1231
(s)-2-(2,4-dihydroxyphenyl)-5,7-dihydroxy-8-((r)-5-methyl-2-(prop-1-en-2-yl)hex-4-en-1-yl)chroman-4-one
Q7563137
CS-0016619
MS-27464
sophoraflavanoneg

Excerpt	Reference	Relevance
" The purpose of this study was to develop a drug delivery system in order to improve oral bioavailability of SFG."	( Solid self-microemulsifying drug delivery system of Sophoraflavanone G: Prescription optimization and pharmacokinetic evaluation. Cheng, J; Hou, L; Shan, B; Wang, R; Wang, Y; Yang, Z, 2019)	0.51

Excerpt	Relevance	Reference
" Therefore, the results show that SFG-S-SMEDDS can significantly improve the oral bioavailability of SFG so as to lay a foundation of further research on the new dosage form of SFG."	( Solid self-microemulsifying drug delivery system of Sophoraflavanone G: Prescription optimization and pharmacokinetic evaluation. Cheng, J; Hou, L; Shan, B; Wang, R; Wang, Y; Yang, Z, 2019)	0.51

Role	Description
antioxidant	A substance that opposes oxidation or inhibits reactions brought about by dioxygen or peroxides.
antimalarial	A drug used in the treatment of malaria. Antimalarials are usually classified on the basis of their action against Plasmodia at different stages in their life cycle in the human.
antimicrobial agent	A substance that kills or slows the growth of microorganisms, including bacteria, viruses, fungi and protozoans.
plant metabolite	Any eukaryotic metabolite produced during a metabolic reaction in plants, the kingdom that include flowering plants, conifers and other gymnosperms.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Class	Description
tetrahydroxyflavanone	A hydroxyflavanone with atleast four hydroxy substituents.
4'-hydroxyflavanones	Any hydroxyflavanone having a hydroxy substituent located at position 4'.
(2S)-flavan-4-one	Any flavanone in which the chiral centre at position 2 has S-configuration.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Voltage-dependent T-type calcium channel subunit alpha-1G	Homo sapiens (human)	IC50 (µMol)	1.0000	0.0370	0.8915	2.5000	AID1398114
Voltage-dependent T-type calcium channel subunit alpha-1H	Homo sapiens (human)	IC50 (µMol)	1.0000	0.0320	1.0479	3.6000	AID1398109
Sodium/glucose cotransporter 1	Homo sapiens (human)	IC50 (µMol)	18.7000	0.0607	1.6105	8.4440	AID295285
Sodium/glucose cotransporter 2	Homo sapiens (human)	IC50 (µMol)	4.1000	0.0005	0.1653	4.1000	AID295286
Beta-secretase 1	Homo sapiens (human)	IC50 (µMol)	5.2000	0.0006	1.6194	10.0000	AID344054
Beta-secretase 1	Homo sapiens (human)	Ki	1.1000	0.0003	1.3524	8.0000	AID344054
Broad substrate specificity ATP-binding cassette transporter ABCG2	Homo sapiens (human)	IC50 (µMol)	2.2050	0.0040	1.9666	10.0000	AID1832660; AID1832661
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Process	via Protein(s)	Taxonomy
sinoatrial node development	Voltage-dependent T-type calcium channel subunit alpha-1G	Homo sapiens (human)
chemical synaptic transmission	Voltage-dependent T-type calcium channel subunit alpha-1G	Homo sapiens (human)
response to nickel cation	Voltage-dependent T-type calcium channel subunit alpha-1G	Homo sapiens (human)
regulation of membrane potential	Voltage-dependent T-type calcium channel subunit alpha-1G	Homo sapiens (human)
regulation of atrial cardiac muscle cell membrane depolarization	Voltage-dependent T-type calcium channel subunit alpha-1G	Homo sapiens (human)
calcium ion import	Voltage-dependent T-type calcium channel subunit alpha-1G	Homo sapiens (human)
calcium ion transmembrane transport	Voltage-dependent T-type calcium channel subunit alpha-1G	Homo sapiens (human)
cardiac muscle cell action potential involved in contraction	Voltage-dependent T-type calcium channel subunit alpha-1G	Homo sapiens (human)
SA node cell action potential	Voltage-dependent T-type calcium channel subunit alpha-1G	Homo sapiens (human)
AV node cell action potential	Voltage-dependent T-type calcium channel subunit alpha-1G	Homo sapiens (human)
SA node cell to atrial cardiac muscle cell signaling	Voltage-dependent T-type calcium channel subunit alpha-1G	Homo sapiens (human)
AV node cell to bundle of His cell signaling	Voltage-dependent T-type calcium channel subunit alpha-1G	Homo sapiens (human)
membrane depolarization during AV node cell action potential	Voltage-dependent T-type calcium channel subunit alpha-1G	Homo sapiens (human)
membrane depolarization during SA node cell action potential	Voltage-dependent T-type calcium channel subunit alpha-1G	Homo sapiens (human)
regulation of heart rate by cardiac conduction	Voltage-dependent T-type calcium channel subunit alpha-1G	Homo sapiens (human)
calcium ion import across plasma membrane	Voltage-dependent T-type calcium channel subunit alpha-1G	Homo sapiens (human)
muscle contraction	Voltage-dependent T-type calcium channel subunit alpha-1H	Homo sapiens (human)
muscle organ development	Voltage-dependent T-type calcium channel subunit alpha-1H	Homo sapiens (human)
myoblast fusion	Voltage-dependent T-type calcium channel subunit alpha-1H	Homo sapiens (human)
regulation of heart contraction	Voltage-dependent T-type calcium channel subunit alpha-1H	Homo sapiens (human)
aldosterone biosynthetic process	Voltage-dependent T-type calcium channel subunit alpha-1H	Homo sapiens (human)
cellular response to hormone stimulus	Voltage-dependent T-type calcium channel subunit alpha-1H	Homo sapiens (human)
cortisol biosynthetic process	Voltage-dependent T-type calcium channel subunit alpha-1H	Homo sapiens (human)
cellular response to potassium ion	Voltage-dependent T-type calcium channel subunit alpha-1H	Homo sapiens (human)
regulation of membrane potential	Voltage-dependent T-type calcium channel subunit alpha-1H	Homo sapiens (human)
calcium ion import	Voltage-dependent T-type calcium channel subunit alpha-1H	Homo sapiens (human)
inorganic cation transmembrane transport	Voltage-dependent T-type calcium channel subunit alpha-1H	Homo sapiens (human)
positive regulation of acrosome reaction	Voltage-dependent T-type calcium channel subunit alpha-1H	Homo sapiens (human)
calcium ion import across plasma membrane	Voltage-dependent T-type calcium channel subunit alpha-1H	Homo sapiens (human)
chloride transmembrane transport	Sodium/glucose cotransporter 1	Homo sapiens (human)
glucose transmembrane transport	Sodium/glucose cotransporter 1	Homo sapiens (human)
alpha-glucoside transport	Sodium/glucose cotransporter 1	Homo sapiens (human)
intestinal D-glucose absorption	Sodium/glucose cotransporter 1	Homo sapiens (human)
response to inorganic substance	Sodium/glucose cotransporter 1	Homo sapiens (human)
pentose transmembrane transport	Sodium/glucose cotransporter 1	Homo sapiens (human)
fucose transmembrane transport	Sodium/glucose cotransporter 1	Homo sapiens (human)
galactose transmembrane transport	Sodium/glucose cotransporter 1	Homo sapiens (human)
myo-inositol transport	Sodium/glucose cotransporter 1	Homo sapiens (human)
transepithelial water transport	Sodium/glucose cotransporter 1	Homo sapiens (human)
renal glucose absorption	Sodium/glucose cotransporter 1	Homo sapiens (human)
glucose import across plasma membrane	Sodium/glucose cotransporter 1	Homo sapiens (human)
sodium ion import across plasma membrane	Sodium/glucose cotransporter 1	Homo sapiens (human)
intestinal hexose absorption	Sodium/glucose cotransporter 1	Homo sapiens (human)
transport across blood-brain barrier	Sodium/glucose cotransporter 1	Homo sapiens (human)
glucose transmembrane transport	Sodium/glucose cotransporter 1	Homo sapiens (human)
sodium ion transport	Sodium/glucose cotransporter 1	Homo sapiens (human)
alpha-glucoside transport	Sodium/glucose cotransporter 2	Homo sapiens (human)
carbohydrate metabolic process	Sodium/glucose cotransporter 2	Homo sapiens (human)
hexose transmembrane transport	Sodium/glucose cotransporter 2	Homo sapiens (human)
renal glucose absorption	Sodium/glucose cotransporter 2	Homo sapiens (human)
glucose import across plasma membrane	Sodium/glucose cotransporter 2	Homo sapiens (human)
sodium ion import across plasma membrane	Sodium/glucose cotransporter 2	Homo sapiens (human)
sodium ion transport	Sodium/glucose cotransporter 2	Homo sapiens (human)
proteolysis	Beta-secretase 1	Homo sapiens (human)
membrane protein ectodomain proteolysis	Beta-secretase 1	Homo sapiens (human)
response to lead ion	Beta-secretase 1	Homo sapiens (human)
protein processing	Beta-secretase 1	Homo sapiens (human)
amyloid-beta formation	Beta-secretase 1	Homo sapiens (human)
amyloid precursor protein catabolic process	Beta-secretase 1	Homo sapiens (human)
positive regulation of neuron apoptotic process	Beta-secretase 1	Homo sapiens (human)
amyloid-beta metabolic process	Beta-secretase 1	Homo sapiens (human)
detection of mechanical stimulus involved in sensory perception of pain	Beta-secretase 1	Homo sapiens (human)
prepulse inhibition	Beta-secretase 1	Homo sapiens (human)
cellular response to copper ion	Beta-secretase 1	Homo sapiens (human)
cellular response to manganese ion	Beta-secretase 1	Homo sapiens (human)
presynaptic modulation of chemical synaptic transmission	Beta-secretase 1	Homo sapiens (human)
signaling receptor ligand precursor processing	Beta-secretase 1	Homo sapiens (human)
cellular response to amyloid-beta	Beta-secretase 1	Homo sapiens (human)
amyloid fibril formation	Beta-secretase 1	Homo sapiens (human)
lipid transport	Broad substrate specificity ATP-binding cassette transporter ABCG2	Homo sapiens (human)
organic anion transport	Broad substrate specificity ATP-binding cassette transporter ABCG2	Homo sapiens (human)
urate transport	Broad substrate specificity ATP-binding cassette transporter ABCG2	Homo sapiens (human)
biotin transport	Broad substrate specificity ATP-binding cassette transporter ABCG2	Homo sapiens (human)
sphingolipid biosynthetic process	Broad substrate specificity ATP-binding cassette transporter ABCG2	Homo sapiens (human)
riboflavin transport	Broad substrate specificity ATP-binding cassette transporter ABCG2	Homo sapiens (human)
urate metabolic process	Broad substrate specificity ATP-binding cassette transporter ABCG2	Homo sapiens (human)
transmembrane transport	Broad substrate specificity ATP-binding cassette transporter ABCG2	Homo sapiens (human)
transepithelial transport	Broad substrate specificity ATP-binding cassette transporter ABCG2	Homo sapiens (human)
renal urate salt excretion	Broad substrate specificity ATP-binding cassette transporter ABCG2	Homo sapiens (human)
export across plasma membrane	Broad substrate specificity ATP-binding cassette transporter ABCG2	Homo sapiens (human)
transport across blood-brain barrier	Broad substrate specificity ATP-binding cassette transporter ABCG2	Homo sapiens (human)
cellular detoxification	Broad substrate specificity ATP-binding cassette transporter ABCG2	Homo sapiens (human)
xenobiotic transport across blood-brain barrier	Broad substrate specificity ATP-binding cassette transporter ABCG2	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Process	via Protein(s)	Taxonomy
low voltage-gated calcium channel activity	Voltage-dependent T-type calcium channel subunit alpha-1G	Homo sapiens (human)
voltage-gated calcium channel activity involved in AV node cell action potential	Voltage-dependent T-type calcium channel subunit alpha-1G	Homo sapiens (human)
voltage-gated calcium channel activity involved SA node cell action potential	Voltage-dependent T-type calcium channel subunit alpha-1G	Homo sapiens (human)
scaffold protein binding	Voltage-dependent T-type calcium channel subunit alpha-1G	Homo sapiens (human)
high voltage-gated calcium channel activity	Voltage-dependent T-type calcium channel subunit alpha-1G	Homo sapiens (human)
voltage-gated monoatomic ion channel activity	Voltage-dependent T-type calcium channel subunit alpha-1H	Homo sapiens (human)
protein binding	Voltage-dependent T-type calcium channel subunit alpha-1H	Homo sapiens (human)
low voltage-gated calcium channel activity	Voltage-dependent T-type calcium channel subunit alpha-1H	Homo sapiens (human)
metal ion binding	Voltage-dependent T-type calcium channel subunit alpha-1H	Homo sapiens (human)
scaffold protein binding	Voltage-dependent T-type calcium channel subunit alpha-1H	Homo sapiens (human)
high voltage-gated calcium channel activity	Voltage-dependent T-type calcium channel subunit alpha-1H	Homo sapiens (human)
galactose transmembrane transporter activity	Sodium/glucose cotransporter 1	Homo sapiens (human)
glucose transmembrane transporter activity	Sodium/glucose cotransporter 1	Homo sapiens (human)
myo-inositol:sodium symporter activity	Sodium/glucose cotransporter 1	Homo sapiens (human)
water transmembrane transporter activity	Sodium/glucose cotransporter 1	Homo sapiens (human)
glucose:sodium symporter activity	Sodium/glucose cotransporter 1	Homo sapiens (human)
protein binding	Sodium/glucose cotransporter 1	Homo sapiens (human)
pentose transmembrane transporter activity	Sodium/glucose cotransporter 1	Homo sapiens (human)
fucose transmembrane transporter activity	Sodium/glucose cotransporter 1	Homo sapiens (human)
alpha-glucoside transmembrane transporter activity	Sodium/glucose cotransporter 1	Homo sapiens (human)
galactose:sodium symporter activity	Sodium/glucose cotransporter 1	Homo sapiens (human)
D-glucose transmembrane transporter activity	Sodium/glucose cotransporter 1	Homo sapiens (human)
low-affinity glucose:sodium symporter activity	Sodium/glucose cotransporter 2	Homo sapiens (human)
glucose:sodium symporter activity	Sodium/glucose cotransporter 2	Homo sapiens (human)
protein binding	Sodium/glucose cotransporter 2	Homo sapiens (human)
alpha-glucoside transmembrane transporter activity	Sodium/glucose cotransporter 2	Homo sapiens (human)
D-glucose transmembrane transporter activity	Sodium/glucose cotransporter 2	Homo sapiens (human)
amyloid-beta binding	Beta-secretase 1	Homo sapiens (human)
endopeptidase activity	Beta-secretase 1	Homo sapiens (human)
aspartic-type endopeptidase activity	Beta-secretase 1	Homo sapiens (human)
protein binding	Beta-secretase 1	Homo sapiens (human)
peptidase activity	Beta-secretase 1	Homo sapiens (human)
beta-aspartyl-peptidase activity	Beta-secretase 1	Homo sapiens (human)
enzyme binding	Beta-secretase 1	Homo sapiens (human)
protein serine/threonine kinase binding	Beta-secretase 1	Homo sapiens (human)
protein binding	Broad substrate specificity ATP-binding cassette transporter ABCG2	Homo sapiens (human)
ATP binding	Broad substrate specificity ATP-binding cassette transporter ABCG2	Homo sapiens (human)
organic anion transmembrane transporter activity	Broad substrate specificity ATP-binding cassette transporter ABCG2	Homo sapiens (human)
ABC-type xenobiotic transporter activity	Broad substrate specificity ATP-binding cassette transporter ABCG2	Homo sapiens (human)
urate transmembrane transporter activity	Broad substrate specificity ATP-binding cassette transporter ABCG2	Homo sapiens (human)
biotin transmembrane transporter activity	Broad substrate specificity ATP-binding cassette transporter ABCG2	Homo sapiens (human)
efflux transmembrane transporter activity	Broad substrate specificity ATP-binding cassette transporter ABCG2	Homo sapiens (human)
ATP hydrolysis activity	Broad substrate specificity ATP-binding cassette transporter ABCG2	Homo sapiens (human)
riboflavin transmembrane transporter activity	Broad substrate specificity ATP-binding cassette transporter ABCG2	Homo sapiens (human)
ATPase-coupled transmembrane transporter activity	Broad substrate specificity ATP-binding cassette transporter ABCG2	Homo sapiens (human)
identical protein binding	Broad substrate specificity ATP-binding cassette transporter ABCG2	Homo sapiens (human)
protein homodimerization activity	Broad substrate specificity ATP-binding cassette transporter ABCG2	Homo sapiens (human)
xenobiotic transmembrane transporter activity	Broad substrate specificity ATP-binding cassette transporter ABCG2	Homo sapiens (human)
sphingolipid transporter activity	Broad substrate specificity ATP-binding cassette transporter ABCG2	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Process	via Protein(s)	Taxonomy
cytoplasm	Voltage-dependent T-type calcium channel subunit alpha-1G	Homo sapiens (human)
plasma membrane	Voltage-dependent T-type calcium channel subunit alpha-1G	Homo sapiens (human)
synapse	Voltage-dependent T-type calcium channel subunit alpha-1G	Homo sapiens (human)
voltage-gated calcium channel complex	Voltage-dependent T-type calcium channel subunit alpha-1G	Homo sapiens (human)
plasma membrane	Voltage-dependent T-type calcium channel subunit alpha-1H	Homo sapiens (human)
membrane	Voltage-dependent T-type calcium channel subunit alpha-1H	Homo sapiens (human)
voltage-gated calcium channel complex	Voltage-dependent T-type calcium channel subunit alpha-1H	Homo sapiens (human)
early endosome	Sodium/glucose cotransporter 1	Homo sapiens (human)
plasma membrane	Sodium/glucose cotransporter 1	Homo sapiens (human)
apical plasma membrane	Sodium/glucose cotransporter 1	Homo sapiens (human)
brush border membrane	Sodium/glucose cotransporter 1	Homo sapiens (human)
intracellular organelle	Sodium/glucose cotransporter 1	Homo sapiens (human)
perinuclear region of cytoplasm	Sodium/glucose cotransporter 1	Homo sapiens (human)
extracellular exosome	Sodium/glucose cotransporter 1	Homo sapiens (human)
intracellular vesicle	Sodium/glucose cotransporter 1	Homo sapiens (human)
plasma membrane	Sodium/glucose cotransporter 1	Homo sapiens (human)
plasma membrane	Sodium/glucose cotransporter 2	Homo sapiens (human)
membrane	Sodium/glucose cotransporter 2	Homo sapiens (human)
apical plasma membrane	Sodium/glucose cotransporter 2	Homo sapiens (human)
extracellular exosome	Sodium/glucose cotransporter 2	Homo sapiens (human)
plasma membrane	Sodium/glucose cotransporter 2	Homo sapiens (human)
lysosome	Beta-secretase 1	Homo sapiens (human)
endosome	Beta-secretase 1	Homo sapiens (human)
early endosome	Beta-secretase 1	Homo sapiens (human)
late endosome	Beta-secretase 1	Homo sapiens (human)
multivesicular body	Beta-secretase 1	Homo sapiens (human)
endoplasmic reticulum lumen	Beta-secretase 1	Homo sapiens (human)
Golgi apparatus	Beta-secretase 1	Homo sapiens (human)
trans-Golgi network	Beta-secretase 1	Homo sapiens (human)
plasma membrane	Beta-secretase 1	Homo sapiens (human)
synaptic vesicle	Beta-secretase 1	Homo sapiens (human)
cell surface	Beta-secretase 1	Homo sapiens (human)
endosome membrane	Beta-secretase 1	Homo sapiens (human)
membrane	Beta-secretase 1	Homo sapiens (human)
axon	Beta-secretase 1	Homo sapiens (human)
dendrite	Beta-secretase 1	Homo sapiens (human)
neuronal cell body	Beta-secretase 1	Homo sapiens (human)
membrane raft	Beta-secretase 1	Homo sapiens (human)
recycling endosome	Beta-secretase 1	Homo sapiens (human)
Golgi-associated vesicle lumen	Beta-secretase 1	Homo sapiens (human)
hippocampal mossy fiber to CA3 synapse	Beta-secretase 1	Homo sapiens (human)
endosome	Beta-secretase 1	Homo sapiens (human)
plasma membrane	Beta-secretase 1	Homo sapiens (human)
trans-Golgi network	Beta-secretase 1	Homo sapiens (human)
nucleoplasm	Broad substrate specificity ATP-binding cassette transporter ABCG2	Homo sapiens (human)
plasma membrane	Broad substrate specificity ATP-binding cassette transporter ABCG2	Homo sapiens (human)
apical plasma membrane	Broad substrate specificity ATP-binding cassette transporter ABCG2	Homo sapiens (human)
brush border membrane	Broad substrate specificity ATP-binding cassette transporter ABCG2	Homo sapiens (human)
mitochondrial membrane	Broad substrate specificity ATP-binding cassette transporter ABCG2	Homo sapiens (human)
membrane raft	Broad substrate specificity ATP-binding cassette transporter ABCG2	Homo sapiens (human)
external side of apical plasma membrane	Broad substrate specificity ATP-binding cassette transporter ABCG2	Homo sapiens (human)
plasma membrane	Broad substrate specificity ATP-binding cassette transporter ABCG2	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (253)

Assay ID	Title	Year	Journal	Article
AID1832613	Chemo-sensitizing activity against ABCB1-overexpressing human KB-V1 cells assessed as colchicine IC50 at 1 uM measured after 72 hrs in presence of colchicine by CCK8 assay (Rvb = 758.22 +/-156.56 nM)	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832485	Chemo-sensitizing activity against human A549 cells assessed as mitoxantrone IC50 at 1 uM measured after 72 hrs in presence of mitoxantrone by CCK8 assay (Rvb = 82.47 +/-24.25 nM)	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832541	Chemo-sensitizing activity against ABCG2-overexpressing human HEK293/482R cells assessed as SN-38 IC50 at 1 uM measured after 72 hrs in presence of SN-38 by CCK8 assay (Rvb = 239.91 +/-25 nM)	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832641	Chemo-sensitizing activity against human HEK293 cells assessed as reversal fold at 2 uM measured after 72 hrs in presence of paclitaxel by CCK8 assay relative to control	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832554	Chemo-sensitizing activity against ABCG2-overexpressing human HEK293 cells assessed as reversal fold at 2 uM measured after 72 hrs in presence of topotecan by CCK8 assay relative to control	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832589	Chemo-sensitizing activity against human KB 3-1 cells assessed as reversal fold at 1 uM measured after 72 hrs in presence of vincristine by CCK8 assay relative to control	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832451	Chemo-sensitizing activity against human NCI-H460 cells assessed as mitoxantrone IC50 at 5 uM measured after 72 hrs in presence of mitoxantrone by CCK8 assay (Rvb = 20.7 +/-6.32 nM)	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832457	Chemo-sensitizing activity against human NCI-H460 cells assessed as topotecan IC50 at 5 uM measured after 72 hrs in presence of topotecan by CCK8 assay (Rvb = 279.69 +/-31.94 nM)	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832573	Chemo-sensitizing activity against ABCB1-overexpressing human NCI/ADR-RES cells assessed as paclitaxel IC50 at 2 uM measured after 72 hrs in presence of paclitaxel by CCK8 assay (Rvb = 7.09 +/-0.89 microM)	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID295285	Inhibition of human SGLT1 expressed in COS1 cells assessed as [14C]methyl-alpha-D-glucopyranoside uptake	2007	Bioorganic & medicinal chemistry, May-15, Volume: 15, Issue:10	Na+-glucose cotransporter (SGLT) inhibitory flavonoids from the roots of Sophora flavescens.
AID1832547	Chemo-sensitizing activity against ABCG2-overexpressing human HEK293/482R cells assessed as reversal fold at 1 uM measured after 72 hrs in presence of mitoxatrone by CCK8 assay relative to control	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832658	Inhibition of ABCG2 in mitoxantrone-selected ABCG2-overexpressing human NCI-H460/MX20 cells assessed as increase in intracellular mitoxantrone accumulation at 20 uM incubated for 1 hr in presence of mitoxantrone by flow cytometry	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832519	Chemo-sensitizing activity against becatecarin-selected ABCG2-overexpressing human A549/Bec150 cells assessed as reversal fold at 1 uM measured after 72 hrs in presence of topotecan by CCK8 assay relative to control	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832644	Chemo-sensitizing activity against ABCB1-overexpressing human HEK293/MDR19 cells assessed as reversal fold at 2 uM measured after 72 hrs in presence of paclitaxel by CCK8 assay relative to control	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832638	Chemo-sensitizing activity against ABCB1-overexpressing human HEK293/MDR19 cells assessed as paclitaxel IC50 at 2 uM measured after 72 hrs in presence of paclitaxel by CCK8 assay (Rvb = 1.31 +/-0.2 microM)	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832667	Cytotoxicity against becatecarin-selected ABCG2-overexpressing human A549/Bec150 cells assessed as cell viability at 1 to 5 uM measured after 72 hrs by CCK8 assay	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832575	Chemo-sensitizing activity against human OVCAR-8 cells assessed as reversal fold at 1 uM measured after 72 hrs in presence of paclitaxel by CCK8 assay relative to control	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832611	Chemo-sensitizing activity against human KB 3-1 cells assessed as colchicine IC50 at 2 uM measured after 72 hrs in presence of colchicine by CCK8 assay (Rvb = 13.78 +/-7.63 nM)	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832665	Cytotoxicity against mitoxantrone-selected ABCG2-overexpressing human NCI-H460/MX20 cells assessed as cell viability at 1 to 5 uM measured after 72 hrs by CCK8 assay	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832538	Chemo-sensitizing activity against human HEK293 cells assessed as SN-38 IC50 at 1 uM measured after 72 hrs in presence of SN-38 by CCK8 assay (Rvb = 2.78 +/-0.58 nM)	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832472	Chemo-sensitizing activity against mitoxantrone-selected ABCG2-overexpressing human NCI-H460/MX20 cells assessed as reversal fold at 5 uM measured after 72 hrs in presence of mitoxantrone by CCK8 assay relative to control	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832439	Chemo-sensitizing activity against human OVCAR-8 cells assessed as vincristine IC50 at 2 uM measured after 72 hrs in presence of vincristine by CCK8 assay (Rvb = 6.01 +/-0.77 nM)	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832571	Chemo-sensitizing activity against human OVCAR-8 cells assessed as paclitaxel IC50 at 5 uM measured after 72 hrs in presence of paclitaxel by CCK8 assay (Rvb = 2.62 +/-0.31 nM)	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832520	Chemo-sensitizing activity against becatecarin-selected ABCG2-overexpressing human A549/Bec150 cells assessed as reversal fold at 2 uM measured after 72 hrs in presence of topotecan by CCK8 assay relative to control	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832574	Chemo-sensitizing activity against ABCB1-overexpressing human NCI/ADR-RES cells assessed as paclitaxel IC50 at 5 uM measured after 72 hrs in presence of paclitaxel by CCK8 assay (Rvb = 7.09 +/-0.89 microM)	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832576	Chemo-sensitizing activity against human OVCAR-8 cells assessed as reversal fold at 2 uM measured after 72 hrs in presence of paclitaxel by CCK8 assay relative to control	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832463	Chemo-sensitizing activity against human NCI-H460 cells assessed as SN-38 IC50 at 5 uM measured after 72 hrs in presence of SN-38 by CCK8 assay (Rvb = 128.27 +/-22.6 nM)	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832660	Inhibition of ABCG2 in mitoxantrone-selected ABCG2-overexpressing human NCI-H460/MX20 cells assessed as increase in intracellular mitoxantrone accumulation incubated for 1 hr in presence of mitoxantrone by flow cytometry	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832650	Chemo-sensitizing activity against ABCB1-overexpressing human HEK293/MDR19 cells assessed as colchicine IC50 at 2 uM measured after 72 hrs in presence of colchicine by CCK8 assay (Rvb = 260 +/-74.23 nM)	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832626	Chemo-sensitizing activity against ABCB1-overexpressing human HEK293/MDR19 cells assessed as vincristine IC50 at 2 uM measured after 72 hrs in presence of vincristine by CCK8 assay (Rvb = 787.11 +/-227.51 nM)	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832655	Chemo-sensitizing activity against ABCB1-overexpressing human HEK293/MDR19 cells assessed as reversal fold at 1 uM measured after 72 hrs in presence of colchicine by CCK8 assay relative to control	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832528	Chemo-sensitizing activity against human HEK293 cells assessed as mitoxantrone IC50 at 5 uM measured after 72 hrs in presence of mitoxantrone by CCK8 assay (Rvb = 2.74 +/-0.69 nM)	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832584	Chemo-sensitizing activity against ABCB1-overexpressing human NCI/ADR-RES cells assessed as reversal fold at 1 uM measured after 72 hrs in presence of colchicine by CCK8 assay relative to control	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832594	Chemo-sensitizing activity against human KB 3-1 cells assessed as reversal fold at 5 uM measured after 72 hrs in presence of vincristine by CCK8 assay relative to control	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832543	Chemo-sensitizing activity against ABCG2-overexpressing human HEK293/482R cells assessed as SN-38 IC50 at 5 uM measured after 72 hrs in presence of SN-38 by CCK8 assay (Rvb = 239.91 +/-25 nM)	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832605	Chemo-sensitizing activity against human KB 3-1 cells assessed as reversal fold at 2 uM measured after 72 hrs in presence of paclitaxel by CCK8 assay relative to control	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832442	Cytotoxicity against human A549 cells assessed as reduction in cell viability measured after 72 hrs by CCK8 assay	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832509	Chemo-sensitizing activity against becatecarin-selected ABCG2-overexpressing human A549/Bec150 cells assessed as SN-38 IC50 at 5 uM measured after 72 hrs in presence of SN-38 by CCK8 assay (Rvb = 1625.4 +/-413.42 nM)	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832493	Chemo-sensitizing activity against human OVCAR-8 cells assessed as colchicine IC50 at 5 uM measured after 72 hrs in presence of colchicine by CCK8 assay (Rvb = 28.73 +/-10.04 nM)	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832478	Chemo-sensitizing activity against mitoxantrone-selected ABCG2-overexpressing human NCI-H460/MX20 cells assessed as reversal fold at 5 uM measured after 72 hrs in presence of topotecan by CCK8 assay relative to control	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832596	Chemo-sensitizing activity against ABCB1-overexpressing human KB-V1 cells assessed as reversal fold at 2 uM measured after 72 hrs in presence of vincristine by CCK8 assay relative to control	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832465	Chemo-sensitizing activity against mitoxantrone-selected ABCG2-overexpressing human NCI-H460/MX20 cells assessed as SN-38 IC50 at 2 uM measured after 72 hrs in presence of SN-38 by CCK8 assay (Rvb = 4.33 +/-1.18 microM)	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832612	Chemo-sensitizing activity against human KB 3-1 cells assessed as colchicine IC50 at 5 uM measured after 72 hrs in presence of colchicine by CCK8 assay (Rvb = 13.78 +/-7.63 nM)	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832635	Chemo-sensitizing activity against human HEK293 cells assessed as paclitaxel IC50 at 2 uM measured after 72 hrs in presence of paclitaxel by CCK8 assay (Rvb = 2.67 +/-0.39 nM)	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832480	Chemo-sensitizing activity against human NCI-H460 cells assessed as reversal fold at 2 uM measured after 72 hrs in presence of SN-38 by CCK8 assay relative to control	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832502	Chemo-sensitizing activity against becatecarin-selected ABCG2-overexpressing human A549/Bec150 cells assessed as topotecan IC50 at 2 uM measured after 72 hrs in presence of topotecan by CCK8 assay (Rvb = 1162.92 +/-250.73 nM)	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832542	Chemo-sensitizing activity against ABCG2-overexpressing human HEK293/482R cells assessed as SN-38 IC50 at 2 uM measured after 72 hrs in presence of SN-38 by CCK8 assay (Rvb = 239.91 +/-25 nM)	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832536	Chemo-sensitizing activity against ABCG2-overexpressing human HEK293/482R cells assessed as topotecan IC50 at 2 uM measured after 72 hrs in presence of topotecan by CCK8 assay (Rvb = 558.68 +/-81.31 nM)	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID410032	Inhibition of Clostridium perfringens neuraminidase by Lineweaver-Burke plot	2008	Bioorganic & medicinal chemistry letters, Dec-01, Volume: 18, Issue:23	Pterocarpans and flavanones from Sophora flavescens displaying potent neuraminidase inhibition.
AID1832552	Chemo-sensitizing activity against human HEK293 cells assessed as reversal fold at 5 uM measured after 72 hrs in presence of topotecan by CCK8 assay relative to control	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID344054	Inhibition of human BACE1	2008	Bioorganic & medicinal chemistry, Jul-15, Volume: 16, Issue:14	BACE1 inhibitory effects of lavandulyl flavanones from Sophora flavescens.
AID1832652	Chemo-sensitizing activity against human HEK293 cells assessed as reversal fold at 1 uM measured after 72 hrs in presence of colchicine by CCK8 assay relative to control	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832647	Chemo-sensitizing activity against human HEK293 cells assessed as colchicine IC50 at 2 uM measured after 72 hrs in presence of colchicine by CCK8 assay (Rvb = 15.36 +/-6.18 nM)	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832470	Chemo-sensitizing activity against mitoxantrone-selected ABCG2-overexpressing human NCI-H460/MX20 cells assessed as reversal fold at 1 uM measured after 72 hrs in presence of mitoxantrone by CCK8 assay relative to control	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832521	Chemo-sensitizing activity against becatecarin-selected ABCG2-overexpressing human A549/Bec150 cells assessed as reversal fold at 5 uM measured after 72 hrs in presence of topotecan by CCK8 assay relative to control	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832497	Chemo-sensitizing activity against ABCB1-overexpressing human NCI/ADR-RES cells assessed as reversal fold at 5 uM measured after 72 hrs in presence of paclitaxel by CCK8 assay relative to control	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832448	Resistance factor, ratio of IC50 for ABCG2-overexpressing human HEK293/482R cells to IC50 for human HEK293 cells	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832607	Chemo-sensitizing activity against ABCB1-overexpressing human KB-V1 cells assessed as reversal fold at 1 uM measured after 72 hrs in presence of paclitaxel by CCK8 assay relative to control	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832585	Chemo-sensitizing activity against ABCB1-overexpressing human NCI/ADR-RES cells assessed as reversal fold at 2 uM measured after 72 hrs in presence of colchicine by CCK8 assay relative to control	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832434	Chemo-sensitizing activity against human HEK293 cells assessed as mitoxantrone IC50 at 1 uM measured after 72 hrs in presence of mitoxantrone by CCK8 assay (Rvb = 2.74 +/-0.69 nM)	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832657	Chemo-sensitizing activity against ABCB1-overexpressing human HEK293/MDR19 cells assessed as reversal fold at 5 uM measured after 72 hrs in presence of colchicine by CCK8 assay relative to control	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832508	Chemo-sensitizing activity against becatecarin-selected ABCG2-overexpressing human A549/Bec150 cells assessed as SN-38 IC50 at 2 uM measured after 72 hrs in presence of SN-38 by CCK8 assay (Rvb = 1625.4 +/-413.42 nM)	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832663	Effect on ABCG2 protein expression in becatecarin-selected ABCG2-overexpressing human A549/Bec150 cells at 1 to 5 uM incubated for 72 hrs by immunoblot analysis	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832545	Chemo-sensitizing activity against human HEK293 cells assessed as reversal fold at 2 uM measured after 72 hrs in presence of mitoxatrone by CCK8 assay relative to control	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832618	Chemo-sensitizing activity against human KB 3-1 cells assessed as reversal fold at 5 uM measured after 72 hrs in presence of colchicine by CCK8 assay relative to control	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832659	Inhibition of ABCG2 in becatecarin-selected ABCG2-overexpressing human A549/Bec150 cells assessed as increase in intracellular mitoxantrone accumulation at 20 uM incubated for 1 hr in presence of mitoxantrone by flow cytometry	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832504	Chemo-sensitizing activity against human A549 cells assessed as SN-38 IC50 at 1 uM measured after 72 hrs in presence of SN-38 by CCK8 assay (Rvb = 376.13 +/-60.17 nM)	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832452	Chemo-sensitizing activity against mitoxantrone-selected ABCG2-overexpressing human NCI-H460/MX20 cells assessed as mitoxantrone IC50 at 1 uM measured after 72 hrs in presence of mitoxantrone by CCK8 assay (Rvb = 963.32 +/-120.89 nM)	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832469	Chemo-sensitizing activity against human NCI-H460 cells assessed as reversal fold at 5 uM measured after 72 hrs in presence of mitoxantrone by CCK8 assay relative to control	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832642	Chemo-sensitizing activity against human HEK293 cells assessed as reversal fold at 5 uM measured after 72 hrs in presence of paclitaxel by CCK8 assay relative to control	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832646	Chemo-sensitizing activity against human HEK293 cells assessed as colchicine IC50 at 1 uM measured after 72 hrs in presence of colchicine by CCK8 assay (Rvb = 15.36 +/-6.18 nM)	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832602	Chemo-sensitizing activity against ABCB1-expressing human KB-V1 cells assessed as paclitaxel IC50 at 2 uM measured after 72 hrs in presence of paclitaxel by CCK8 assay (Rvb = 2.73 +/-0.42 microM)	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832517	Chemo-sensitizing activity against human A549 cells assessed as reversal fold at 2 uM measured after 72 hrs in presence of topotecan by CCK8 assay relative to control	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832633	Chemo-sensitizing activity against ABCB1-overexpressing human HEK293/MDR19 cells assessed as reversal fold at 5 uM measured after 72 hrs in presence of vincristine by CCK8 assay relative to control	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832535	Chemo-sensitizing activity against ABCG2-overexpressing human HEK293/482R cells assessed as topotecan IC50 at 1 uM measured after 72 hrs in presence of topotecan by CCK8 assay (Rvb = 558.68 +/-81.31 nM)	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832661	Inhibition of ABCG2 in becatecarin-selected ABCG2-overexpressing human A549/Bec150 cells assessed as increase in intracellular mitoxantrone accumulation incubated for 1 hr in presence of mitoxantrone by flow cytometry	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832610	Chemo-sensitizing activity against human KB 3-1 cells assessed as colchicine IC50 at 1 uM measured after 72 hrs in presence of colchicine by CCK8 assay (Rvb = 13.78 +/-7.63 nM)	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832639	Chemo-sensitizing activity against ABCB1-overexpressing human HEK293/MDR19 cells assessed as paclitaxel IC50 at 5 uM measured after 72 hrs in presence of paclitaxel by CCK8 assay (Rvb = 1.31 +/-0.2 microM)	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832549	Chemo-sensitizing activity against ABCG2-overexpressing human HEK293/482R cells assessed as reversal fold at 5 uM measured after 72 hrs in presence of mitoxatrone by CCK8 assay relative to control	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832507	Chemo-sensitizing activity against becatecarin-selected ABCG2-overexpressing human A549/Bec150 cells assessed as SN-38 IC50 at 1 uM measured after 72 hrs in presence of SN-38 by CCK8 assay (Rvb = 1625.4 +/-413.42 nM)	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832537	Chemo-sensitizing activity against ABCG2-overexpressing human HEK293/482R cells assessed as topotecan IC50 at 5 uM measured after 72 hrs in presence of topotecan by CCK8 assay (Rvb = 558.68 +/-81.31 nM)	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832526	Chemo-sensitizing activity against becatecarin-selected ABCG2-overexpressing human A549/Bec150 cells assessed as reversal fold at 2 uM measured after 72 hrs in presence of SN-38 by CCK8 assay relative to control	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832625	Chemo-sensitizing activity against ABCB1-overexpressing human HEK293/MDR19 cells assessed as vincristine IC50 at 1 uM measured after 72 hrs in presence of vincristine by CCK8 assay (Rvb = 787.11 +/-227.51 nM)	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832597	Chemo-sensitizing activity against ABCB1-overexpressing human KB-V1 cells assessed as reversal fold at 5 uM measured after 72 hrs in presence of vincristine by CCK8 assay relative to control	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832496	Chemo-sensitizing activity against human KB 3-1 cells assessed as vincristine IC50 at 2 uM measured after 72 hrs in presence of vincristine by CCK8 assay (Rvb = 1.19 +/-0.39 nM)	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832557	Chemo-sensitizing activity against human HEK293 cells assessed as reversal fold at 2 uM measured after 72 hrs in presence of SN-38 by CCK8 assay relative to control	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832445	Cytotoxicity against ABCG2-overexpressing human HEK293/482R cells assessed as reduction in cell viability measured after 72 hrs by CCK8 assay	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832533	Chemo-sensitizing activity against human HEK293 cells assessed as topotecan IC50 at 2 uM measured after 72 hrs in presence of topotecan by CCK8 assay (Rvb = 35.17 +/-8.65 nM)	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832568	Chemo-sensitizing activity against ABCB1-overexpressing human NCI/ADR-RES cells assessed as reversal fold at 5 uM measured after 72 hrs in presence of vincristine by CCK8 assay relative to control	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832449	Chemo-sensitizing activity against human NCI-H460 cells assessed as mitoxantrone IC50 at 1 uM measured after 72 hrs in presence of mitoxantrone by CCK8 assay (Rvb = 20.7 +/-6.32 nM)	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832525	Chemo-sensitizing activity against becatecarin-selected ABCG2-overexpressing human A549/Bec150 cells assessed as reversal fold at 1 uM measured after 72 hrs in presence of SN-38 by CCK8 assay relative to control	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832539	Chemo-sensitizing activity against human HEK293 cells assessed as SN-38 IC50 at 2 uM measured after 72 hrs in presence of SN-38 by CCK8 assay (Rvb = 2.78 +/-0.58 nM)	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832486	Chemo-sensitizing activity against human A549 cells assessed as mitoxantrone IC50 at 2 uM measured after 72 hrs in presence of mitoxantrone by CCK8 assay (Rvb = 82.47 +/-24.25 nM)	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832572	Chemo-sensitizing activity against ABCB1-overexpressing human NCI/ADR-RES cells assessed as paclitaxel IC50 at 1 uM measured after 72 hrs in presence of paclitaxel by CCK8 assay (Rvb = 7.09 +/-0.89 microM)	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832484	Chemo-sensitizing activity against mitoxantrone-selected ABCG2-overexpressing human NCI-H460/MX20 cells assessed as reversal fold at 5 uM measured after 72 hrs in presence of SN-38 by CCK8 assay relative to control	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832653	Chemo-sensitizing activity against human HEK293 cells assessed as reversal fold at 2 uM measured after 72 hrs in presence of colchicine by CCK8 assay relative to control	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832570	Chemo-sensitizing activity against human OVCAR-8 cells assessed as paclitaxel IC50 at 2 uM measured after 72 hrs in presence of paclitaxel by CCK8 assay (Rvb = 2.62 +/-0.31 nM)	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832514	Chemo-sensitizing activity against becatecarin-selected ABCG2-overexpressing human A549/Bec150 cells assessed as reversal fold at 2 uM measured after 72 hrs in presence of mitoxantrone by CCK8 assay relative to control	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832588	Chemo-sensitizing activity against human KB 3-1 cells assessed as vincristine IC50 at 5 uM measured after 72 hrs in presence of vincristine by CCK8 assay (Rvb = 1.19 +/-0.39 nM)	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832534	Chemo-sensitizing activity against human HEK293 cells assessed as topotecan IC50 at 5 uM measured after 72 hrs in presence of topotecan by CCK8 assay (Rvb = 35.17 +/-8.65 nM)	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832566	Chemo-sensitizing activity against ABCB1-overexpressing human NCI/ADR-RES cells assessed as reversal fold at 1 uM measured after 72 hrs in presence of vincristine by CCK8 assay relative to control	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832559	Chemo-sensitizing activity against ABCG2-overexpressing human HEK293/482R cells assessed as reversal fold at 1 uM measured after 72 hrs in presence of SN-38 by CCK8 assay relative to control	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832551	Chemo-sensitizing activity against human HEK293 cells assessed as reversal fold at 2 uM measured after 72 hrs in presence of topotecan by CCK8 assay relative to control	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832475	Chemo-sensitizing activity against human NCI-H460 cells assessed as reversal fold at 5 uM measured after 72 hrs in presence of topotecan by CCK8 assay relative to control	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832593	Chemo-sensitizing activity against human KB 3-1 cells assessed as reversal fold at 2 uM measured after 72 hrs in presence of vincristine by CCK8 assay relative to control	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832435	Chemo-sensitizing activity against ABCB1-overexpressing human NCI/ADR-RES cells assessed as vincristine IC50 at 1 uM measured after 72 hrs in presence of vincristine by CCK8 assay (Rvb = 5.57 +/-0.96 microM)	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832565	Chemo-sensitizing activity against human OVCAR-8 cells assessed as reversal fold at 5 uM measured after 72 hrs in presence of vincristine by CCK8 assay relative to control	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832567	Chemo-sensitizing activity against ABCB1-overexpressing human NCI/ADR-RES cells assessed as reversal fold at 2 uM measured after 72 hrs in presence of vincristine by CCK8 assay relative to control	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832609	Chemo-sensitizing activity against ABCB1-overexpressing human KB-V1 cells assessed as reversal fold at 5 uM measured after 72 hrs in presence of paclitaxel by CCK8 assay relative to control	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832630	Chemo-sensitizing activity against human HEK293 cells assessed as reversal fold at 5 uM measured after 72 hrs in presence of vincristine by CCK8 assay relative to control	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832586	Chemo-sensitizing activity against ABCB1-overexpressing human NCI/ADR-RES cells assessed as reversal fold at 5 uM measured after 72 hrs in presence of colchicine by CCK8 assay relative to control	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832515	Chemo-sensitizing activity against becatecarin-selected ABCG2-overexpressing human A549/Bec150 cells assessed as reversal fold at 5 uM measured after 72 hrs in presence of mitoxantrone by CCK8 assay relative to control	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832524	Chemo-sensitizing activity against human A549 cells assessed as reversal fold at 5 uM measured after 72 hrs in presence of SN-38 by CCK8 assay relative to control	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832654	Chemo-sensitizing activity against human HEK293 cells assessed as reversal fold at 5 uM measured after 72 hrs in presence of colchicine by CCK8 assay relative to control	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832583	Chemo-sensitizing activity against human OVCAR-8 cells assessed as reversal fold at 5 uM measured after 72 hrs in presence of colchicine by CCK8 assay relative to control	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832666	Cytotoxicity against human A549 cells assessed as cell viability at 1 to 5 uM measured after 72 hrs by CCK8 assay	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832454	Chemo-sensitizing activity against mitoxantrone-selected ABCG2-overexpressing human NCI-H460/MX20 cells assessed as mitoxantrone IC50 at 5 uM measured after 72 hrs in presence of mitoxantrone by CCK8 assay (Rvb = 963.32 +/-120.89 nM)	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832468	Chemo-sensitizing activity against human NCI-H460 cells assessed as reversal fold at 2 uM measured after 72 hrs in presence of mitoxantrone by CCK8 assay relative to control	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832462	Chemo-sensitizing activity against human NCI-H460 cells assessed as SN-38 IC50 at 2 uM measured after 72 hrs in presence of SN-38 by CCK8 assay (Rvb = 128.27 +/-22.6 nM)	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID295283	Inhibition of human SGLT1 expressed in COS1 cells assessed as [14C]methyl-alpha-D-glucopyranoside uptake at 50 uM	2007	Bioorganic & medicinal chemistry, May-15, Volume: 15, Issue:10	Na+-glucose cotransporter (SGLT) inhibitory flavonoids from the roots of Sophora flavescens.
AID1832569	Chemo-sensitizing activity against human OVCAR-8 cells assessed as paclitaxel IC50 at 1 uM measured after 72 hrs in presence of paclitaxel by CCK8 assay (Rvb = 2.62 +/-0.31 nM)	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832595	Chemo-sensitizing activity against ABCB1-overexpressing human KB-V1 cells assessed as reversal fold at 1 uM measured after 72 hrs in presence of vincristine by CCK8 assay relative to control	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID295284	Inhibition of human SGLT2 expressed in COS1 cells assessed as [14C]methyl-alpha-D-glucopyranoside uptake at 50 uM	2007	Bioorganic & medicinal chemistry, May-15, Volume: 15, Issue:10	Na+-glucose cotransporter (SGLT) inhibitory flavonoids from the roots of Sophora flavescens.
AID1832499	Chemo-sensitizing activity against human A549 cells assessed as topotecan IC50 at 2 uM measured after 72 hrs in presence of topotecan by CCK8 assay (Rvb =555.44 +/-125.7 nM)	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832531	Chemo-sensitizing activity against ABCG2-overexpressing human HEK293/482R cells cells assessed as mitoxantrone IC50 at 5 uM measured after 72 hrs in presence of mitoxantrone by CCK8 assay (Rvb = 99.55 +/-7.35 nM)	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832628	Chemo-sensitizing activity against human HEK293 cells assessed as reversal fold at 1 uM measured after 72 hrs in presence of vincristine by CCK8 assay relative to control	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID380063	Cytotoxicity against human HL60 cells after 96 hrs by MTT assay	2000	Journal of natural products, May, Volume: 63, Issue:5	Cytotoxic lavandulyl flavanones from Sophora flavescens.
AID1832546	Chemo-sensitizing activity against human HEK293 cells assessed as reversal fold at 5 uM measured after 72 hrs in presence of mitoxatrone by CCK8 assay relative to control	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832608	Chemo-sensitizing activity against ABCB1-overexpressing human KB-V1 cells assessed as reversal fold at 2 uM measured after 72 hrs in presence of paclitaxel by CCK8 assay relative to control	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832555	Chemo-sensitizing activity against ABCG2-overexpressing human HEK293 cells assessed as reversal fold at 5 uM measured after 72 hrs in presence of topotecan by CCK8 assay relative to control	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832616	Chemo-sensitizing activity against human KB 3-1 cells assessed as reversal fold at 1 uM measured after 72 hrs in presence of colchicine by CCK8 assay relative to control	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832622	Chemo-sensitizing activity against human HEK293 cells assessed as vincristine IC50 at 1 uM measured after 72 hrs in presence of vincristine by CCK8 assay (Rvb = 2.29 +/-0.35 nM)	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832479	Chemo-sensitizing activity against human NCI-H460 cells assessed as reversal fold at 1 uM measured after 72 hrs in presence of SN-38 by CCK8 assay relative to control	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832580	Chemo-sensitizing activity against ABCB1-overexpressing human NCI/ADR-RES cells assessed as colchicine IC50 at 5 uM measured after 72 hrs in presence of colchicine by CCK8 assay (Rvb = 2.63 +/-0.62 microM)	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832656	Chemo-sensitizing activity against ABCB1-overexpressing human HEK293/MDR19 cells assessed as reversal fold at 2 uM measured after 72 hrs in presence of colchicine by CCK8 assay relative to control	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832482	Chemo-sensitizing activity against mitoxantrone-selected ABCG2-overexpressing human NCI-H460/MX20 cells assessed as reversal fold at 1 uM measured after 72 hrs in presence of SN-38 by CCK8 assay relative to control	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832503	Chemo-sensitizing activity against becatecarin-selected ABCG2-overexpressing human A549/Bec150 cells assessed as topotecan IC50 at 5 uM measured after 72 hrs in presence of topotecan by CCK8 assay (Rvb = 1162.92 +/-250.73 nM)	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832636	Chemo-sensitizing activity against human HEK293 cells assessed as paclitaxel IC50 at 5 uM measured after 72 hrs in presence of paclitaxel by CCK8 assay (Rvb = 2.67 +/-0.39 nM)	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832460	Chemo-sensitizing activity against mitoxantrone-selected ABCG2-overexpressing human NCI-H460MX20 cells assessed as topotecan IC50 at 5 uM measured after 72 hrs in presence of topotecan by CCK8 assay (Rvb = 3262.6 +/-811.81 nM)	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1238084	Cytotoxicity against mouse RAW264.7 cells assessed as cell viability at IC50 by MTT assay	2015	Bioorganic & medicinal chemistry letters, Aug-15, Volume: 25, Issue:16	Chemical constituents isolated from the Mongolian medicinal plant Sophora alopecuroides L. and their inhibitory effects on LPS-induced nitric oxide production in RAW 264.7 macrophages.
AID344053	Inhibition of human BACE1 expressed in HEK293 cells assessed as reduction in soluble APPbeta level after 4 hrs by Western blot analysis	2008	Bioorganic & medicinal chemistry, Jul-15, Volume: 16, Issue:14	BACE1 inhibitory effects of lavandulyl flavanones from Sophora flavescens.
AID1832488	Chemo-sensitizing activity against becatecarin-selected ABCG2-overexpressing human A549/Bec150 cells assessed as mitoxantrone IC50 at 1 uM measured after 72 hrs in presence of mitoxantrone by CCK8 assay (Rvb = 552.97 +/-106.74 nM)	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832564	Chemo-sensitizing activity against human OVCAR-8 cells assessed as reversal fold at 2 uM measured after 72 hrs in presence of vincristine by CCK8 assay relative to control	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832632	Chemo-sensitizing activity against ABCB1-overexpressing human HEK293/MDR19 cells assessed as reversal fold at 2 uM measured after 72 hrs in presence of vincristine by CCK8 assay relative to control	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832562	Chemo-sensitizing activity against ABCB1-overexpressing human NCI/ADR-RES cells assessed as vincristine IC50 at 5 uM measured after 72 hrs in presence of vincristine by CCK8 assay (Rvb = 5.57 +/-0.96 microM)	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832619	Chemo-sensitizing activity against ABCB1-oveexpressing human KB-V1 cells assessed as reversal fold at 1 uM measured after 72 hrs in presence of colchicine by CCK8 assay relative to control	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832491	Chemo-sensitizing activity against human A549 cells assessed as topotecan IC50 at 1 uM measured after 72 hrs in presence of topotecan by CCK8 assay (Rvb =555.44 +/-125.7 nM)	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832483	Chemo-sensitizing activity against mitoxantrone-selected ABCG2-overexpressing human NCI-H460/MX20 cells assessed as reversal fold at 2 uM measured after 72 hrs in presence of SN-38 by CCK8 assay relative to control	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832500	Chemo-sensitizing activity against human A549 cells assessed as topotecan IC50 at 5 uM measured after 72 hrs in presence of topotecan by CCK8 assay (Rvb =555.44 +/-125.7 nM)	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832579	Chemo-sensitizing activity against ABCB1-overexpressing human NCI/ADR-RES cells assessed as colchicine IC50 at 2 uM measured after 72 hrs in presence of colchicine by CCK8 assay (Rvb = 2.63 +/-0.62 microM)	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1238082	Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-stimulated nitric oxide production after 24 hrs by Griess method	2015	Bioorganic & medicinal chemistry letters, Aug-15, Volume: 25, Issue:16	Chemical constituents isolated from the Mongolian medicinal plant Sophora alopecuroides L. and their inhibitory effects on LPS-induced nitric oxide production in RAW 264.7 macrophages.
AID1832476	Chemo-sensitizing activity against mitoxantrone-selected ABCG2-overexpressing human NCI-H460/MX20 cells assessed as reversal fold at 1 uM measured after 72 hrs in presence of topotecan by CCK8 assay relative to control	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832620	Chemo-sensitizing activity against ABCB1-oveexpressing human KB-V1 cells assessed as reversal fold at 2 uM measured after 72 hrs in presence of colchicine by CCK8 assay relative to control	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832599	Chemo-sensitizing activity against human KB 3-1 cells assessed as paclitaxel IC50 at 2 uM measured after 72 hrs in presence of paclitaxel by CCK8 assay (Rvb = 2.29 +/-0.75 nM)	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1491116	Toxicity in 7-days post fertilized zebra fish larvae after 1.5 to 24 hrs by microscopic analysis	2017	Journal of natural products, 05-26, Volume: 80, Issue:5	HPLC-Based Activity Profiling for GABA
AID1832473	Chemo-sensitizing activity against human NCI-H460 cells assessed as reversal fold at 1 uM measured after 72 hrs in presence of topotecan by CCK8 assay relative to control	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832471	Chemo-sensitizing activity against mitoxantrone-selected ABCG2-overexpressing human NCI-H460/MX20 cells assessed as reversal fold at 2 uM measured after 72 hrs in presence of mitoxantrone by CCK8 assay relative to control	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832446	Resistance factor, ratio of IC50 for mitoxantrone-selected ABCG2-overexpressing human NCI-H460/MX20 cells to IC50 for human NCI-H460 cells	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832587	Chemo-sensitizing activity against human KB 3-1 cells assessed as vincristine IC50 at 1 uM measured after 72 hrs in presence of vincristine by CCK8 assay (Rvb = 1.19 +/-0.39 nM)	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832438	Chemo-sensitizing activity against human OVCAR-8 cells assessed as vincristine IC50 at 1 uM measured after 72 hrs in presence of vincristine by CCK8 assay (Rvb = 6.01 +/-0.77 nM)	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832498	Chemo-sensitizing activity against ABCB1-overexpressing human NCI/ADR-RES cells assessed as reversal fold at 2 uM measured after 72 hrs in presence of paclitaxel by CCK8 assay relative to control	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832441	Cytotoxicity against mitoxantrone-selected ABCG2-overexpressing human NCI-H460/MX20 cells assessed as reduction in cell viability measured after 72 hrs by CCK8 assay	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832443	Cytotoxicity against becatecarin-selected ABCG2-overexpressing human A549/Bec150 cells assessed as reduction in cell viability measured after 72 hrs by CCK8 assay	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832513	Chemo-sensitizing activity against becatecarin-selected ABCG2-overexpressing human A549/Bec150 cells assessed as reversal fold at 1 uM measured after 72 hrs in presence of mitoxantrone by CCK8 assay relative to control	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832556	Chemo-sensitizing activity against human HEK293 cells assessed as reversal fold at 1 uM measured after 72 hrs in presence of SN-38 by CCK8 assay relative to control	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832458	Chemo-sensitizing activity against mitoxantrone-selected ABCG2-overexpressing human NCI-H460/MX20 cells assessed as topotecan IC50 at 1 uM measured after 72 hrs in presence of topotecan by CCK8 assay (Rvb = 3262.6 +/-811.81 nM)	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832645	Chemo-sensitizing activity against ABCB1-overexpressing human HEK293/MDR19 cells assessed as reversal fold at 5 uM measured after 72 hrs in presence of paclitaxel by CCK8 assay relative to control	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832490	Chemo-sensitizing activity against becatecarin-selected ABCG2-overexpressing human A549/Bec150 cells assessed as mitoxantrone IC50 at 5 uM measured after 72 hrs in presence of mitoxantrone by CCK8 assay (Rvb = 552.97 +/-106.74 nM)	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832621	Chemo-sensitizing activity against ABCB1-oveexpressing human KB-V1 cells assessed as reversal fold at 5 uM measured after 72 hrs in presence of colchicine by CCK8 assay relative to control	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1398109	Inhibition of human CaV3.2 expressed in HEK293 cells assessed as suppression of T-current amplitude after 10 mins by whole cell patch clamp method	2018	Bioorganic & medicinal chemistry, 08-15, Volume: 26, Issue:15	Design and synthesis of novel anti-hyperalgesic agents based on 6-prenylnaringenin as the T-type calcium channel blockers.
AID1832577	Chemo-sensitizing activity against human OVCAR-8 cells assessed as reversal fold at 5 uM measured after 72 hrs in presence of paclitaxel by CCK8 assay relative to control	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832516	Chemo-sensitizing activity against human A549 cells assessed as reversal fold at 1 uM measured after 72 hrs in presence of topotecan by CCK8 assay relative to control	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832598	Chemo-sensitizing activity against human KB 3-1 cells assessed as paclitaxel IC50 at 1 uM measured after 72 hrs in presence of paclitaxel by CCK8 assay (Rvb = 2.29 +/-0.75 nM)	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832590	Chemo-sensitizing activity against ABCB1-overexpressing human KB-V1 cells assessed as vincristine IC50 at 1 uM measured after 72 hrs in presence of vincristine by CCK8 assay (Rvb = 1745 +/-293.01 nM)	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832637	Chemo-sensitizing activity against ABCB1-overexpressing human HEK293/MDR19 cells assessed as paclitaxel IC50 at 1 uM measured after 72 hrs in presence of paclitaxel by CCK8 assay (Rvb = 1.31 +/-0.2 microM)	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832489	Chemo-sensitizing activity against becatecarin-selected ABCG2-overexpressing human A549/Bec150 cells assessed as mitoxantrone IC50 at 2 uM measured after 72 hrs in presence of mitoxantrone by CCK8 assay (Rvb = 552.97 +/-106.74 nM)	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832600	Chemo-sensitizing activity against human KB 3-1 cells assessed as paclitaxel IC50 at 5 uM measured after 72 hrs in presence of paclitaxel by CCK8 assay (Rvb = 2.29 +/-0.75 nM)	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832527	Chemo-sensitizing activity against becatecarin-selected ABCG2-overexpressing human A549/Bec150 cells assessed as reversal fold at 5 uM measured after 72 hrs in presence of SN-38 by CCK8 assay relative to control	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832662	Effect on ABCG2 protein expression in mitoxantrone-selected ABCG2-overexpressing human NCI-H460/MX20 cells at 1 to 5 uM incubated for 72 hrs by immunoblot analysis	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832505	Chemo-sensitizing activity against human A549 cells assessed as SN-38 IC50 at 2 uM measured after 72 hrs in presence of SN-38 by CCK8 assay (Rvb = 376.13 +/-60.17 nM)	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832466	Chemo-sensitizing activity against mitoxantrone-selected ABCG2-overexpressing human NCI-H460/MX20 cells assessed as SN-38 IC50 at 5 uM measured after 72 hrs in presence of SN-38 by CCK8 assay (Rvb = 4.33 +/-1.18 microM)	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832548	Chemo-sensitizing activity against ABCG2-overexpressing human HEK293/482R cells assessed as reversal fold at 2 uM measured after 72 hrs in presence of mitoxatrone by CCK8 assay relative to control	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832455	Chemo-sensitizing activity against human NCI-H460 cells assessed as topotecan IC50 at 1 uM measured after 72 hrs in presence of topotecan by CCK8 assay (Rvb = 279.69 +/-31.94 nM)	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1491118	Anticonvulsant activity in 7-days post fertilized zebra fish larvae assessed as reduction in pentylenetetrazol-induced locomotor activity by measuring total distance traveled by larvae at 1.25 to 10 uM pretreated for 3 hrs followed by pentylenetetrazol ad	2017	Journal of natural products, 05-26, Volume: 80, Issue:5	HPLC-Based Activity Profiling for GABA
AID1832563	Chemo-sensitizing activity against human OVCAR-8 cells assessed as reversal fold at 1 uM measured after 72 hrs in presence of vincristine by CCK8 assay relative to control	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832615	Chemo-sensitizing activity against ABCB1-overexpressing human KB-V1 cells assessed as colchicine IC50 at 5 uM measured after 72 hrs in presence of colchicine by CCK8 assay (Rvb = 758.22 +/-156.56 nM)	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832487	Chemo-sensitizing activity against human A549 cells assessed as mitoxantrone IC50 at 5 uM measured after 72 hrs in presence of mitoxantrone by CCK8 assay (Rvb = 82.47 +/-24.25 nM)	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832623	Chemo-sensitizing activity against human HEK293 cells assessed as vincristine IC50 at 2 uM measured after 72 hrs in presence of vincristine by CCK8 assay (Rvb = 2.29 +/-0.35 nM)	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832669	Cytotoxicity against ABCG2-overexpressing human HEK293/482R cells assessed as cell viability at 1 to 5 uM measured after 72 hrs by CCK8 assay	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832558	Chemo-sensitizing activity against human HEK293 cells assessed as reversal fold at 5 uM measured after 72 hrs in presence of SN-38 by CCK8 assay relative to control	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832477	Chemo-sensitizing activity against mitoxantrone-selected ABCG2-overexpressing human NCI-H460/MX20 cells assessed as reversal fold at 2 uM measured after 72 hrs in presence of topotecan by CCK8 assay relative to control	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832581	Chemo-sensitizing activity against human OVCAR-8 cells assessed as reversal fold at 1 uM measured after 72 hrs in presence of colchicine by CCK8 assay relative to control	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832433	Chemo-sensitizing activity against human HEK293 cells assessed as mitoxantrone IC50 at 2 uM measured after 72 hrs in presence of mitoxantrone by CCK8 assay (Rvb = 2.74 +/-0.69 nM)	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832532	Chemo-sensitizing activity against human HEK293 cells assessed as topotecan IC50 at 1 uM measured after 72 hrs in presence of topotecan by CCK8 assay (Rvb = 35.17 +/-8.65 nM)	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832649	Chemo-sensitizing activity against ABCB1-overexpressing human HEK293/MDR19 cells assessed as colchicine IC50 at 1 uM measured after 72 hrs in presence of colchicine by CCK8 assay (Rvb = 260 +/-74.23 nM)	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832444	Cytotoxicity against human HEK293 cells assessed as reduction in cell viability measured after 72 hrs by CCK8 assay	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832591	Chemo-sensitizing activity against ABCB1-overexpressing human KB-V1 cells assessed as vincristine IC50 at 2 uM measured after 72 hrs in presence of vincristine by CCK8 assay (Rvb = 1745 +/-293.01 nM)	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832530	Chemo-sensitizing activity against ABCG2-overexpressing human HEK293/482R cells cells assessed as mitoxantrone IC50 at 2 uM measured after 72 hrs in presence of mitoxantrone by CCK8 assay (Rvb = 99.55 +/-7.35 nM)	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832627	Chemo-sensitizing activity against ABCB1-overexpressing human HEK293/MDR19 cells assessed as vincristine IC50 at 5 uM measured after 72 hrs in presence of vincristine by CCK8 assay (Rvb = 787.11 +/-227.51 nM)	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832578	Chemo-sensitizing activity against ABCB1-overexpressing human NCI/ADR-RES cells assessed as colchicine IC50 at 1 uM measured after 72 hrs in presence of colchicine by CCK8 assay (Rvb = 2.63 +/-0.62 microM)	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832560	Chemo-sensitizing activity against ABCG2-overexpressing human HEK293/482R cells assessed as reversal fold at 2 uM measured after 72 hrs in presence of SN-38 by CCK8 assay relative to control	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832617	Chemo-sensitizing activity against human KB 3-1 cells assessed as reversal fold at 2 uM measured after 72 hrs in presence of colchicine by CCK8 assay relative to control	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID344052	Inhibition of human BACE1 expressed in HEK293 cells assessed as reduction in soluble APPalpha level after 4 hrs by Western blot analysis	2008	Bioorganic & medicinal chemistry, Jul-15, Volume: 16, Issue:14	BACE1 inhibitory effects of lavandulyl flavanones from Sophora flavescens.
AID1832467	Chemo-sensitizing activity against human NCI-H460 cells assessed as reversal fold at 1 uM measured after 72 hrs in presence of mitoxantrone by CCK8 assay relative to control	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832629	Chemo-sensitizing activity against human HEK293 cells assessed as reversal fold at 2 uM measured after 72 hrs in presence of vincristine by CCK8 assay relative to control	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832664	Cytotoxicity against human NCI-H460 cells assessed as cell viability at 1 to 5 uM measured after 72 hrs by CCK8 assay	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832561	Chemo-sensitizing activity against ABCG2-overexpressing human HEK293/482R cells assessed as reversal fold at 5 uM measured after 72 hrs in presence of SN-38 by CCK8 assay relative to control	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832540	Chemo-sensitizing activity against human HEK293 cells assessed as SN-38 IC50 at 5 uM measured after 72 hrs in presence of SN-38 by CCK8 assay (Rvb = 2.78 +/-0.58 nM)	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832634	Chemo-sensitizing activity against human HEK293 cells assessed as paclitaxel IC50 at 1 uM measured after 72 hrs in presence of paclitaxel by CCK8 assay (Rvb = 2.67 +/-0.39 nM)	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832523	Chemo-sensitizing activity against human A549 cells assessed as reversal fold at 2 uM measured after 72 hrs in presence of SN-38 by CCK8 assay relative to control	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832501	Chemo-sensitizing activity against becatecarin-selected ABCG2-overexpressing human A549/Bec150 cells assessed as topotecan IC50 at 1 uM measured after 72 hrs in presence of topotecan by CCK8 assay (Rvb = 1162.92 +/-250.73 nM)	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832518	Chemo-sensitizing activity against human A549 cells assessed as reversal fold at 5 uM measured after 72 hrs in presence of topotecan by CCK8 assay relative to control	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832440	Cytotoxicity against human NCI-H460 cells assessed as reduction in cell viability measured after 72 hrs by CCK8 assay	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832592	Chemo-sensitizing activity against ABCB1-overexpressing human KB-V1 cells assessed as vincristine IC50 at 5 uM measured after 72 hrs in presence of vincristine by CCK8 assay (Rvb = 1745 +/-293.01 nM)	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832614	Chemo-sensitizing activity against ABCB1-overexpressing human KB-V1 cells assessed as colchicine IC50 at 2 uM measured after 72 hrs in presence of colchicine by CCK8 assay (Rvb = 758.22 +/-156.56 nM)	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832643	Chemo-sensitizing activity against ABCB1-overexpressing human HEK293/MDR19 cells assessed as reversal fold at 1 uM measured after 72 hrs in presence of paclitaxel by CCK8 assay relative to control	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832464	Chemo-sensitizing activity against mitoxantrone-selected ABCG2-overexpressing human NCI-H460/MX20 cells assessed as SN-38 IC50 at 1 uM measured after 72 hrs in presence of SN-38 by CCK8 assay (Rvb = 4.33 +/-1.18 microM)	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832494	Chemo-sensitizing activity against human OVCAR-8 cells assessed as colchicine IC50 at 2 uM measured after 72 hrs in presence of colchicine by CCK8 assay (Rvb = 28.73 +/-10.04 nM)	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832550	Chemo-sensitizing activity against human HEK293 cells assessed as reversal fold at 1 uM measured after 72 hrs in presence of topotecan by CCK8 assay relative to control	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832529	Chemo-sensitizing activity against ABCG2-overexpressing human HEK293/482R cells cells assessed as mitoxantrone IC50 at 1 uM measured after 72 hrs in presence of mitoxantrone by CCK8 assay (Rvb = 99.55 +/-7.35 nM)	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832510	Chemo-sensitizing activity against human A549 cells assessed as reversal fold at 1 uM measured after 72 hrs in presence of mitoxantrone by CCK8 assay relative to control	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832450	Chemo-sensitizing activity against human NCI-H460 cells assessed as mitoxantrone IC50 at 2 uM measured after 72 hrs in presence of mitoxantrone by CCK8 assay (Rvb = 20.7 +/-6.32 nM)	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832582	Chemo-sensitizing activity against human OVCAR-8 cells assessed as reversal fold at 2 uM measured after 72 hrs in presence of colchicine by CCK8 assay relative to control	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832631	Chemo-sensitizing activity against ABCB1-overexpressing human HEK293/MDR19 cells assessed as reversal fold at 1 uM measured after 72 hrs in presence of vincristine by CCK8 assay relative to control	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832437	Chemo-sensitizing activity against human OVCAR-8 cells assessed as vincristine IC50 at 5 uM measured after 72 hrs in presence of vincristine by CCK8 assay (Rvb = 6.01 +/-0.77 nM)	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832481	Chemo-sensitizing activity against human NCI-H460 cells assessed as reversal fold at 5 uM measured after 72 hrs in presence of SN-38 by CCK8 assay relative to control	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832474	Chemo-sensitizing activity against human NCI-H460 cells assessed as reversal fold at 2 uM measured after 72 hrs in presence of topotecan by CCK8 assay relative to control	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832495	Chemo-sensitizing activity against human OVCAR-8 cells assessed as colchicine IC50 at 1 uM measured after 72 hrs in presence of colchicine by CCK8 assay (Rvb = 28.73 +/-10.04 nM)	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832648	Chemo-sensitizing activity against human HEK293 cells assessed as colchicine IC50 at 5 uM measured after 72 hrs in presence of colchicine by CCK8 assay (Rvb = 15.36 +/-6.18 nM)	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832511	Chemo-sensitizing activity against human A549 cells assessed as reversal fold at 2 uM measured after 72 hrs in presence of mitoxantrone by CCK8 assay relative to control	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832606	Chemo-sensitizing activity against human KB 3-1 cells assessed as reversal fold at 5 uM measured after 72 hrs in presence of paclitaxel by CCK8 assay relative to control	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832640	Chemo-sensitizing activity against human HEK293 cells assessed as reversal fold at 1 uM measured after 72 hrs in presence of paclitaxel by CCK8 assay relative to control	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1398114	Inhibition of human CaV3.1 expressed in HEK293 cells assessed as suppression of T-current after 10 mins by whole cell patch clamp method	2018	Bioorganic & medicinal chemistry, 08-15, Volume: 26, Issue:15	Design and synthesis of novel anti-hyperalgesic agents based on 6-prenylnaringenin as the T-type calcium channel blockers.
AID410031	Inhibition of Clostridium perfringens neuraminidase	2008	Bioorganic & medicinal chemistry letters, Dec-01, Volume: 18, Issue:23	Pterocarpans and flavanones from Sophora flavescens displaying potent neuraminidase inhibition.
AID1832492	Chemo-sensitizing activity against ABCB1-overexpressing human NCI/ADR-RES cells assessed as reversal fold at 1 uM measured after 72 hrs in presence of paclitaxel by CCK8 assay relative to control	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID295286	Inhibition of human SGLT2 expressed in COS1 cells assessed as [14C]methyl-alpha-D-glucopyranoside uptake	2007	Bioorganic & medicinal chemistry, May-15, Volume: 15, Issue:10	Na+-glucose cotransporter (SGLT) inhibitory flavonoids from the roots of Sophora flavescens.
AID1832603	Chemo-sensitizing activity against ABCB1-expressing human KB-V1 cells assessed as paclitaxel IC50 at 5 uM measured after 72 hrs in presence of paclitaxel by CCK8 assay (Rvb = 2.73 +/-0.42 microM)	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832651	Chemo-sensitizing activity against ABCB1-overexpressing human HEK293/MDR19 cells assessed as colchicine IC50 at 5 uM measured after 72 hrs in presence of colchicine by CCK8 assay (Rvb = 260 +/-74.23 nM)	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832459	Chemo-sensitizing activity against mitoxantrone-selected ABCG2-overexpressing human NCI-H460/MX20 cells assessed as topotecan IC50 at 2 uM measured after 72 hrs in presence of topotecan by CCK8 assay (Rvb = 3262.6 +/-811.81 nM)	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832522	Chemo-sensitizing activity against human A549 cells assessed as reversal fold at 1 uM measured after 72 hrs in presence of SN-38 by CCK8 assay relative to control	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832453	Chemo-sensitizing activity against mitoxantrone-selected ABCG2-overexpressing human NCI-H460/MX20 cells assessed as mitoxantrone IC50 at 2 uM measured after 72 hrs in presence of mitoxantrone by CCK8 assay (Rvb = 963.32 +/-120.89 nM)	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832624	Chemo-sensitizing activity against human HEK293 cells assessed as vincristine IC50 at 5 uM measured after 72 hrs in presence of vincristine by CCK8 assay (Rvb = 2.29 +/-0.35 nM)	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832447	Resistance factor, ratio of IC50 for becatecarin-selected ABCG2-overexpressing human A549/Bec150 cells to IC50 for human A549 cells	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832544	Chemo-sensitizing activity against human HEK293 cells assessed as reversal fold at 1 uM measured after 72 hrs in presence of mitoxatrone by CCK8 assay relative to control	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832506	Chemo-sensitizing activity against human A549 cells assessed as SN-38 IC50 at 5 uM measured after 72 hrs in presence of SN-38 by CCK8 assay (Rvb = 376.13 +/-60.17 nM)	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832461	Chemo-sensitizing activity against human NCI-H460 cells assessed as SN-38 IC50 at 1 uM measured after 72 hrs in presence of SN-38 by CCK8 assay (Rvb = 128.27 +/-22.6 nM)	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832553	Chemo-sensitizing activity against ABCG2-overexpressing human HEK293 cells assessed as reversal fold at 1 uM measured after 72 hrs in presence of topotecan by CCK8 assay relative to control	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832604	Chemo-sensitizing activity against human KB 3-1 cells assessed as reversal fold at 1 uM measured after 72 hrs in presence of paclitaxel by CCK8 assay relative to control	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832601	Chemo-sensitizing activity against ABCB1-expressing human KB-V1 cells assessed as paclitaxel IC50 at 1 uM measured after 72 hrs in presence of paclitaxel by CCK8 assay (Rvb = 2.73 +/-0.42 microM)	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832668	Cytotoxicity against human HEK293 cells assessed as cell viability at 1 to 5 uM measured after 72 hrs by CCK8 assay	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832456	Chemo-sensitizing activity against human NCI-H460 cells assessed as topotecan IC50 at 2 uM measured after 72 hrs in presence of topotecan by CCK8 assay (Rvb = 279.69 +/-31.94 nM)	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832436	Chemo-sensitizing activity against ABCB1-overexpressing human NCI/ADR-RES cells assessed as vincristine IC50 at 2 uM measured after 72 hrs in presence of vincristine by CCK8 assay (Rvb = 5.57 +/-0.96 microM)	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
AID1832512	Chemo-sensitizing activity against human A549 cells assessed as reversal fold at 5 uM measured after 72 hrs in presence of mitoxantrone by CCK8 assay relative to control	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	3 (6.52)	18.2507
2000's	13 (28.26)	29.6817
2010's	24 (52.17)	24.3611
2020's	6 (13.04)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	1 (2.13%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	46 (97.87%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
carbon monoxide Carbon Monoxide: Carbon monoxide (CO). A poisonous colorless, odorless, tasteless gas. It combines with hemoglobin to form carboxyhemoglobin, which has no oxygen carrying capacity. The resultant oxygen deprivation causes headache, dizziness, decreased pulse and respiratory rates, unconsciousness, and death. (From Merck Index, 11th ed). carbon monoxide : A one-carbon compound in which the carbon is joined only to a single oxygen. It is a colourless, odourless, tasteless, toxic gas.	2	1	carbon oxide; gas molecular entity; one-carbon compound	biomarker; EC 1.9.3.1 (cytochrome c oxidase) inhibitor; human metabolite; ligand; metabolite; mitochondrial respiratory-chain inhibitor; mouse metabolite; neurotoxin; neurotransmitter; P450 inhibitor; probe; signalling molecule; vasodilator agent
methanol Methanol: A colorless, flammable liquid used in the manufacture of FORMALDEHYDE and ACETIC ACID, in chemical synthesis, antifreeze, and as a solvent. Ingestion of methanol is toxic and may cause blindness.. primary alcohol : A primary alcohol is a compound in which a hydroxy group, -OH, is attached to a saturated carbon atom which has either three hydrogen atoms attached to it or only one other carbon atom and two hydrogen atoms attached to it.. methanol : The primary alcohol that is the simplest aliphatic alcohol, comprising a methyl and an alcohol group.	1.97	1	alkyl alcohol; one-carbon compound; primary alcohol; volatile organic compound	amphiprotic solvent; Escherichia coli metabolite; fuel; human metabolite; mouse metabolite; Mycoplasma genitalium metabolite
croton oil [no description available]	2.92	1	N-acyl-hexosamine
2,2'-azobis(2-amidinopropane) 2,2'-azobis(2-amidinopropane): water-soluble free-radical initiator	2.03	1	monoazo compound
pimagedine pimagedine: diamine oxidase & nitric oxide synthase inhibitor; an advanced glycosylation end product inhibitor; used in the treatment of diabetic complications; structure. aminoguanidine : A one-carbon compound whose unique structure renders it capable of acting as a derivative of hydrazine, guanidine or formamide.	2.11	1	guanidines; one-carbon compound	EC 1.14.13.39 (nitric oxide synthase) inhibitor; EC 1.4.3.4 (monoamine oxidase) inhibitor
diazepam Diazepam: A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of action. Its actions are mediated by enhancement of GAMMA-AMINOBUTYRIC ACID activity.. diazepam : A 1,4-benzodiazepinone that is 1,3-dihydro-2H-1,4-benzodiazepin-2-one substituted by a chloro group at position 7, a methyl group at position 1 and a phenyl group at position 5.	2.15	1	1,4-benzodiazepinone; organochlorine compound	anticonvulsant; anxiolytic drug; environmental contaminant; sedative; xenobiotic
ethosuximide Ethosuximide: An anticonvulsant especially useful in the treatment of absence seizures unaccompanied by other types of seizures.. ethosuximide : A dicarboximide that is pyrrolidine-2,5-dione in which the hydrogens at position 3 are substituted by one methyl and one ethyl group. An antiepileptic, it is used in the treatment of absence seizures and may be used for myoclonic seizures, but is ineffective against tonic-clonic seizures.	2.17	1	dicarboximide; pyrrolidinone	anticonvulsant; geroprotector; T-type calcium channel blocker
gentamicin Gentamicins: A complex of closely related aminoglycosides obtained from MICROMONOSPORA purpurea and related species. They are broad-spectrum antibiotics, but may cause ear and kidney damage. They act to inhibit PROTEIN BIOSYNTHESIS.	2.03	1
norfloxacin Norfloxacin: A synthetic fluoroquinolone (FLUOROQUINOLONES) with broad-spectrum antibacterial activity against most gram-negative and gram-positive bacteria. Norfloxacin inhibits bacterial DNA GYRASE.. norfloxacin : A quinolinemonocarboxylic acid with broad-spectrum antibacterial activity against most gram-negative and gram-positive bacteria. Norfloxacin is bactericidal and its mode of action depends on blocking of bacterial DNA replication by binding itself to an enzyme called DNA gyrase.	2.25	1	fluoroquinolone antibiotic; N-arylpiperazine; quinolinemonocarboxylic acid; quinolone antibiotic; quinolone	antibacterial drug; DNA synthesis inhibitor; environmental contaminant; xenobiotic
prednisolone Prednisolone: A glucocorticoid with the general properties of the corticosteroids. It is the drug of choice for all conditions in which routine systemic corticosteroid therapy is indicated, except adrenal deficiency states.. prednisolone : A glucocorticoid that is prednisone in which the oxo group at position 11 has been reduced to the corresponding beta-hydroxy group. It is a drug metabolite of prednisone.	2.92	1	11beta-hydroxy steroid; 17alpha-hydroxy steroid; 20-oxo steroid; 21-hydroxy steroid; 3-oxo-Delta(1),Delta(4)-steroid; C21-steroid; glucocorticoid; primary alpha-hydroxy ketone; tertiary alpha-hydroxy ketone	adrenergic agent; anti-inflammatory drug; antineoplastic agent; drug metabolite; environmental contaminant; immunosuppressive agent; xenobiotic
sucrose Saccharum: A plant genus of the family POACEAE widely cultivated in the tropics for the sweet cane that is processed into sugar.	2.25	1	glycosyl glycoside	algal metabolite; Escherichia coli metabolite; human metabolite; mouse metabolite; osmolyte; Saccharomyces cerevisiae metabolite; sweetening agent
tyrosine Tyrosine: A non-essential amino acid. In animals it is synthesized from PHENYLALANINE. It is also the precursor of EPINEPHRINE; THYROID HORMONES; and melanin.. tyrosine : An alpha-amino acid that is phenylalanine bearing a hydroxy substituent at position 4 on the phenyl ring.	2.08	1	amino acid zwitterion; erythrose 4-phosphate/phosphoenolpyruvate family amino acid; L-alpha-amino acid; proteinogenic amino acid; tyrosine	EC 1.3.1.43 (arogenate dehydrogenase) inhibitor; fundamental metabolite; micronutrient; nutraceutical
phlorhizin [no description available]	2.03	1	aryl beta-D-glucoside; dihydrochalcones; monosaccharide derivative	antioxidant; plant metabolite
1,2-dipalmitoylphosphatidylcholine 1,2-Dipalmitoylphosphatidylcholine: Synthetic phospholipid used in liposomes and lipid bilayers to study biological membranes. It is also a major constituent of PULMONARY SURFACTANTS.	2	1
oxacillin Oxacillin: An antibiotic similar to FLUCLOXACILLIN used in resistant staphylococci infections.. oxacillin : A penicillin antibiotic carrying a 5-methyl-3-phenylisoxazole-4-carboxamide group at position 6beta.	2.05	1	penicillin	antibacterial agent; antibacterial drug
ampicillin Ampicillin: Semi-synthetic derivative of penicillin that functions as an orally active broad-spectrum antibiotic.. ampicillin : A penicillin in which the substituent at position 6 of the penam ring is a 2-amino-2-phenylacetamido group.	2.44	2	beta-lactam antibiotic; penicillin allergen; penicillin	antibacterial drug
isoprene isoprene: used in manufacture of ''synthetic'' rubber, butyl rubber; copolymer in production of elastomers; structure. isoprene : A hemiterpene with the formula CH2=C(CH3)CH=CH2; the monomer of natural rubber and a common structure motif to the isoprenoids, a large class of other naturally occurring compounds.	2.01	1	alkadiene; hemiterpene; volatile organic compound	plant metabolite
pentane Pentanes: Five-carbon saturated hydrocarbon group of the methane series. Include isomers and derivatives.. pentane : A straight chain alkane consisting of 5 carbon atoms.	2.01	1	alkane; volatile organic compound	non-polar solvent; refrigerant
flavanone flavanone: RN given refers to cpd with unspecified isomeric designation; structure in first source. flavanone : The simplest member of the class of flavanones that consists of flavan bearing an oxo substituent at position 4.	3.85	3	flavanones
malondialdehyde Malondialdehyde: The dialdehyde of malonic acid.. malonaldehyde : A dialdehyde that is propane substituted by two oxo groups at the terminal carbon atoms respectively. A biomarker of oxidative damage to lipids caused by smoking, it exists in vivo mainly in the enol form.	2.13	1	dialdehyde	biomarker
durapatite Durapatite: The mineral component of bones and teeth; it has been used therapeutically as a prosthetic aid and in the prevention and treatment of osteoporosis.. hydroxylapatite : A phosphate mineral with the formula Ca5(PO4)3(OH).	2.06	1
mibefradil Mibefradil: A benzimidazoyl-substituted tetraline that selectively binds and inhibits CALCIUM CHANNELS, T-TYPE.	2.17	1	tetralins	T-type calcium channel blocker
glucose, (beta-d)-isomer beta-D-glucose : D-Glucopyranose with beta configuration at the anomeric centre.. (1->4)-beta-D-glucan : A beta-D-glucan in which the glucose units are connected by (1->4) linkages.. (1->3)-beta-D-glucan : A beta-D-glucan in which the glucose units are connected by (1->3) linkages.	2.08	1	D-glucopyranose	epitope; mouse metabolite
spizofurone [no description available]	1.97	1	benzofurans
magnolol [no description available]	2.15	1	biphenyls
inermin inermin: phytoalexin produced in plants after injection with fungi; RN given refers to (cis-(+-))-isomer; RN for cpd without isomeric designation; structure. (-)-maackiain : The (-)-enantiomer of maackiain.	2.71	3	maackiain
dehydroabietic acid dehydroabietic acid: major aquatic toxicant in effluent of pulp and paper mills. dehydroabietic acid : An abietane diterpenoid that is abieta-8,11,13-triene substituted at position 18 by a carboxy group.. dehydroabietate : A monocarboxylic acid anion that is the conjugate base of dehydroabietic acid, obtained by deprotonation of the carboxy group.	2.15	1	abietane diterpenoid; carbotricyclic compound; monocarboxylic acid	allergen; metabolite
tariquidar [no description available]	2.31	1	benzamides
isobavachin isobavachin: RN given for (S)-isomer; structure in first source	2.11	1	flavanones
sandaracopimaric acid sandaracopimaric acid: a terpenoid from Sagittaria sanittifolia L.. sandaracopimaric acid : A pimarane diterpenoid that is (1S,4aS,4bS,7R,10aS)-1,4a,7-trimethyl-1,2,3,4,4a,4b,5,6,7,9,10,10a-dodecahydrophenanthrene carrying a carboxy group at position 1 and a vinyl group at position 7. It is a natural product found in several plant species.	2.15	1	monocarboxylic acid; pimarane diterpenoid; tricyclic diterpenoid	plant metabolite
benzofurans Benzofurans: Compounds that contain a BENZENE ring fused to a furan ring.	1.97	1
naringenin (S)-naringenin : The (S)-enantiomer of naringenin.	2.44	2	(2S)-flavan-4-one; naringenin	expectorant; plant metabolite
trifolirhizin trifolirhizin: from Sophora flavescens; has inhibitory effect on tyrosinase and melanin synthesis; structure in first source	2.77	3	pterocarpans
8-prenylnaringenin 8-prenylnaringenin: a phytogenic antineoplastic agent; structure in first source. sophoraflavanone B : A trihydroxyflavanone that is (S)-naringenin having a prenyl group at position 8.	2.17	1	(2S)-flavan-4-one; 4'-hydroxyflavanones; trihydroxyflavanone	plant metabolite; platelet aggregation inhibitor
pallidol pallidol: isolated from Ciccus pallida; structure in first source. pallidol : A tetracyclic stilbenoid that is a homodimer obtained by cyclodimerisation of resveratrol.	2.11	1	carbopolycyclic compound; polyphenol; stilbenoid	antifungal agent; antioxidant; plant metabolite
8-isopentenylnaringenin 8-isopentenylnaringenin: a non-steroidal phytoestrogen from Anaxagorea luzonensis; structure in first source	2.11	1	flavanones
isoxanthohumol isoxanthohumol: structure in first source	2.04	1	flavanones
piperine piperine : A N-acylpiperidine that is piperidine substituted by a (1E,3E)-1-(1,3-benzodioxol-5-yl)-5-oxopenta-1,3-dien-5-yl group at the nitrogen atom. It is an alkaloid isolated from the plant Piper nigrum.	2.15	1	benzodioxoles; N-acylpiperidine; piperidine alkaloid; tertiary carboxamide	food component; human blood serum metabolite; NF-kappaB inhibitor; plant metabolite
nadp [no description available]	2	1
ovalbumin Ovalbumin: An albumin obtained from the white of eggs. It is a member of the serpin superfamily.	2.41	1
(S)-4',5,7-Trihydroxy-6-prenylflavanone [no description available]	2.17	1	flavanones
leachianone g leachianone G: structure in first source. leachianone G : A tetrahydroxyflavanone having the hydroxy groups at the 2'-, 4'-, 5- and 7-positions and a prenyl group at 8-position.	2.01	1	(2S)-flavan-4-one; 4'-hydroxyflavanones; tetrahydroxyflavanone
dinoprostone prostaglandin E2 : Prostaglandin F2alpha in which the hydroxy group at position 9 has been oxidised to the corresponding ketone. Prostaglandin E2 is the most common and most biologically potent of mammalian prostaglandins.	2.8	3	prostaglandins E	human metabolite; mouse metabolite; oxytocic
formononetin [no description available]	2.42	2	4'-methoxyisoflavones; 7-hydroxyisoflavones	phytoestrogen; plant metabolite
mangiferin shamimin: isolated from the leaves of Bombax ceiba; structure in first source	2.04	1	C-glycosyl compound; xanthones	anti-inflammatory agent; antioxidant; hypoglycemic agent; plant metabolite
sirolimus Sirolimus: A macrolide compound obtained from Streptomyces hygroscopicus that acts by selectively blocking the transcriptional activation of cytokines thereby inhibiting cytokine production. It is bioactive only when bound to IMMUNOPHILINS. Sirolimus is a potent immunosuppressant and possesses both antifungal and antineoplastic properties.. sirolimus : A macrolide lactam isolated from Streptomyces hygroscopicus consisting of a 29-membered ring containing 4 trans double bonds, three of which are conjugated. It is an antibiotic, immunosupressive and antineoplastic agent.	2.25	1	antibiotic antifungal drug; cyclic acetal; cyclic ketone; ether; macrolide lactam; organic heterotricyclic compound; secondary alcohol	antibacterial drug; anticoronaviral agent; antineoplastic agent; bacterial metabolite; geroprotector; immunosuppressive agent; mTOR inhibitor
1-palmitoyl-2-oleoylphosphatidylcholine 1-palmitoyl-2-oleoylphosphatidylcholine: RN given refers to (Z)-isomer	2	1
valerenic acid valerenic acid: a saturated oplopanone type indene from Valeriana officinalis. valerenic acid : A monocarboxylic acid that is 2-methylprop-2-enoic acid which is substituted at position 3 by a 3,7-dimethyl-2,4,5,6,7,7a-hexahydro-1H-inden-4-yl group. A bicyclic sesquiterpenoid constituent of the essential oil of the Valerian plant.	2.15	1	carbobicyclic compound; monocarboxylic acid; sesquiterpenoid	GABA modulator; plant metabolite; sedative; volatile oil component
sophoflavescenol sophoflavescenol: a prenylated flavonol from the roots of Sophora flavescens; structure in first source	3.31	1
ko 143 [no description available]	2.31	1	beta-carbolines; tert-butyl ester
2'-methoxykurarinone 2'-methoxykurarinone: cytotoxic lavandulyl flavanone from Sophora flavescens; structure in first source. (2S)-2'-methoxykurarinone : A dimethoxyflavanone that is (2S)-(-)-kurarinone in which the hydroxy group at position 2' is replaced by a methoxy group. Isolated from the roots of Sophora flavescens, it exhibits cytotoxicity against human myeloid leukemia HL-60 cells.	2.42	2	4'-hydroxyflavanones; dihydroxyflavanone; dimethoxyflavanone	antineoplastic agent; metabolite
cytochrome c-t Cytochromes c: Cytochromes of the c type that are found in eukaryotic MITOCHONDRIA. They serve as redox intermediates that accept electrons from MITOCHONDRIAL ELECTRON TRANSPORT COMPLEX III and transfer them to MITOCHONDRIAL ELECTRON TRANSPORT COMPLEX IV.	2.57	2
phosphatidylcholines Phosphatidylcholines: Derivatives of PHOSPHATIDIC ACIDS in which the phosphoric acid is bound in ester linkage to a CHOLINE moiety.	2	1	1,2-diacyl-sn-glycero-3-phosphocholine
kurarinone kurarinone: cytotoxic lavandulyl flavanone from Sophora flavescens; structure in first source	3.32	6
kuraridin kuraridin: isolated from Sophora flavescens; structure in first source	4.1	4
Kushenol A kushenol A: a tyrosinase inhibitor derived from Sophora flavescens	2.44	2	flavanones
kurarinol kurarinol: from Sophora flavescens; has inhibitory effect on tyrosinase and melanin synthesis; structure in first source. kurarinol : A trihydroxyflavanone that is (2S)-flavanone substituted by hydroxy groups at positions 7, 2' and 4' , a methoxy group at position 5 and a (2S)-5-hydroxy-5-methyl-2-(prop-1-en-2-yl)hexyl group at position 8 respectively.	2.44	2	4'-hydroxyflavanones; monomethoxyflavanone; trihydroxyflavanone	anti-inflammatory agent; antioxidant; plant metabolite
leachianone a leachianone A: isolated from the Chinese herbal medicine Radix Sophorae; structure in first source. leachianone A : A trihydroxyflavanone that is (2S)-flavanone substituted by a lavandulyl group at position 8, hydroxy groups at positions 5, 7 and 4' and a methoxy group at position 2'. Isolated from the roots of Sophora flavescens and Sophora leachiana, it exhibits antineoplastic and antimalarial activity.	2.95	4	4'-hydroxyflavanones; monomethoxyflavanone; trihydroxyflavanone	antimalarial; antineoplastic agent; metabolite

Condition	Relationship Strength	Studies
Acute Confusional Senile Dementia [description not available]	2.04	1
Alzheimer Disease A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)	2.04	1
Absence Seizure [description not available]	2.15	1
Seizures Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.	2.15	1
Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.	2.61	2
Nerve Pain [description not available]	2.17	1
Neuralgia Intense or aching pain that occurs along the course or distribution of a peripheral or cranial nerve.	2.17	1
Carcinoma, Non-Small Cell Lung [description not available]	2.31	1
Carcinoma, Non-Small-Cell Lung A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENOCARCINOMA; and LARGE CELL CARCINOMA. They are dealt with collectively because of their shared treatment strategy.	2.31	1
ER-Negative PR-Negative HER2-Negative Breast Cancer [description not available]	2.69	2
Triple Negative Breast Neoplasms Breast neoplasms that do not express ESTROGEN RECEPTORS; PROGESTERONE RECEPTORS; and do not overexpress the NEU RECEPTOR/HER-2 PROTO-ONCOGENE PROTEIN.	2.69	2
Ciliophora Infections Infections with protozoa of the phylum CILIOPHORA.	2.41	1
Fish Diseases Diseases of freshwater, marine, hatchery or aquarium fish. This term includes diseases of both teleosts (true fish) and elasmobranchs (sharks, rays and skates).	2.41	1
Asthma, Bronchial [description not available]	2.41	1
Innate Inflammatory Response [description not available]	3.08	4
Airway Hyper-Responsiveness [description not available]	2.41	1
Asthma A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).	2.41	1
Inflammation A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.	3.08	4
Chronic Illness [description not available]	2.25	1
Chronic Disease Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care (Dictionary of Health Services Management, 2d ed). For epidemiological studies chronic disease often includes HEART DISEASES; STROKE; CANCER; and diabetes (DIABETES MELLITUS, TYPE 2).	2.25	1
Depression Depressive states usually of moderate intensity in contrast with MAJOR DEPRESSIVE DISORDER present in neurotic and psychotic disorders.	2.25	1
Blood Poisoning [description not available]	2.25	1
Infections, Staphylococcal [description not available]	2.25	1
Staphylococcal Infections Infections with bacteria of the genus STAPHYLOCOCCUS.	2.25	1
Sepsis Systemic inflammatory response syndrome with a proven or suspected infectious etiology. When sepsis is associated with organ dysfunction distant from the site of infection, it is called severe sepsis. When sepsis is accompanied by HYPOTENSION despite adequate fluid infusion, it is called SEPTIC SHOCK.	2.25	1
Congenital Zika Syndrome [description not available]	2.15	1
Break-Bone Fever [description not available]	2.15	1
Zika Virus Infection A viral disease transmitted by the bite of AEDES mosquitoes infected with ZIKA VIRUS. Its mild DENGUE-like symptoms include fever, rash, headaches and ARTHRALGIA. The viral infection during pregnancy, in rare cases, is associated with congenital brain and ocular abnormalities, called Congenital Zika Syndrome, including MICROCEPHALY and may also lead to GUILLAIN-BARRE SYNDROME.	2.15	1
Dengue An acute febrile disease transmitted by the bite of AEDES mosquitoes infected with DENGUE VIRUS. It is self-limiting and characterized by fever, myalgia, headache, and rash. SEVERE DENGUE is a more virulent form of dengue.	2.15	1
Acute Promyelocytic Leukemia [description not available]	2.13	1
Leukemia, Promyelocytic, Acute An acute myeloid leukemia in which abnormal PROMYELOCYTES predominate. It is frequently associated with DISSEMINATED INTRAVASCULAR COAGULATION.	2.13	1
Sensitivity and Specificity Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)	2.13	1
Alloxan Diabetes [description not available]	2.13	1
Bone Loss, Osteoclastic [description not available]	2.13	1
Age-Related Osteoporosis [description not available]	2.13	1
Osteoporosis Reduction of bone mass without alteration in the composition of bone, leading to fractures. Primary osteoporosis can be of two major types: postmenopausal osteoporosis (OSTEOPOROSIS, POSTMENOPAUSAL) and age-related or senile osteoporosis.	2.13	1
Anasarca [description not available]	2.92	1
Edema Abnormal fluid accumulation in TISSUES or body cavities. Most cases of edema are present under the SKIN in SUBCUTANEOUS TISSUE.	2.92	1
Caries, Dental [description not available]	1.98	1
Dental Caries Localized destruction of the tooth surface initiated by decalcification of the enamel followed by enzymatic lysis of organic structures and leading to cavity formation. If left unchecked, the cavity may penetrate the enamel and dentin and reach the pulp.	1.98	1
Gastric Ulcer [description not available]	2.38	2
Stomach Ulcer Ulceration of the GASTRIC MUCOSA due to contact with GASTRIC JUICE. It is often associated with HELICOBACTER PYLORI infection or consumption of nonsteroidal anti-inflammatory drugs (NSAIDS).	2.38	2

vexibinol

Description

Cross-References

Synonyms (25)

Research Excerpts

Bioavailability

Dosage Studied

Roles (4)

Drug Classes (3)

Protein Targets (6)

Inhibition Measurements

Biological Processes (73)

Molecular Functions (39)

Ceullar Components (32)

Bioassays (253)

Research

Studies (46)

Study Types

vexibinol

Description

Cross-References

Synonyms (25)

Research Excerpts

Bioavailability

Dosage Studied

Roles (4)

Drug Classes (3)

Protein Targets (6)

Inhibition Measurements

Biological Processes (73)

Molecular Functions (39)

Ceullar Components (32)

Bioassays (253)

Research

Studies (46)

Study Types

Related Drugs (58)

Related Conditions (42)