norfloxacin has been researched along with Leptospirosis in 3 studies
Norfloxacin: A synthetic fluoroquinolone (FLUOROQUINOLONES) with broad-spectrum antibacterial activity against most gram-negative and gram-positive bacteria. Norfloxacin inhibits bacterial DNA GYRASE.
norfloxacin : A quinolinemonocarboxylic acid with broad-spectrum antibacterial activity against most gram-negative and gram-positive bacteria. Norfloxacin is bactericidal and its mode of action depends on blocking of bacterial DNA replication by binding itself to an enzyme called DNA gyrase.
Leptospirosis: Infections with bacteria of the genus LEPTOSPIRA.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Many antibiotics at appropriate concentrations improved the survival rate and alleviated tissue injury, while, when dosing strategies fall below subtherapeutic levels, worse therapeutic effects are seen." | 5.46 | Low-dose norfloxacin and ciprofloxacin therapy worsen leptospirosis in hamster. ( Cao, Y; Guo, J; Jin, X; Lin, T; Wang, T; Wu, D; Wu, R; Xie, X; Zhang, W, 2017) |
| " Low-dose Norfloxacin (Nor) has been reported to suppress the immune response and worsen leptospirosis." | 3.88 | Low-dose Norfloxacin-treated leptospires induce less IL-1β release in J774A.1 cells following discrepant leptospiral gene expression. ( Cao, Y; Tu, C; Wu, D; Xie, X; Zhang, W, 2018) |
| " Many antibiotics at appropriate concentrations improved the survival rate and alleviated tissue injury, while, when dosing strategies fall below subtherapeutic levels, worse therapeutic effects are seen." | 1.46 | Low-dose norfloxacin and ciprofloxacin therapy worsen leptospirosis in hamster. ( Cao, Y; Guo, J; Jin, X; Lin, T; Wang, T; Wu, D; Wu, R; Xie, X; Zhang, W, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cao, Y | 3 |
| Xie, X | 2 |
| Zhang, W | 3 |
| Wu, D | 2 |
| Tu, C | 1 |
| Zhang, N | 1 |
| Wang, W | 1 |
| Wang, F | 1 |
| Gong, Y | 1 |
| Jiang, H | 1 |
| Zhang, Z | 1 |
| Liu, X | 1 |
| Song, X | 1 |
| Wang, T | 2 |
| Ding, Z | 1 |
| Lin, T | 1 |
| Jin, X | 1 |
| Guo, J | 1 |
| Wu, R | 1 |
3 other studies available for norfloxacin and Leptospirosis
| Article | Year |
|---|---|
Low-dose Norfloxacin-treated leptospires induce less IL-1β release in J774A.1 cells following discrepant leptospiral gene expression.
Topics: Animals; Antigens, Bacterial; Bacterial Outer Membrane Proteins; Bacterial Proteins; Cell Line; Flag | 2018 |
Efficacy of cefepime, ertapenem and norfloxacin against leptospirosis and for the clearance of pathogens in a hamster model.
Topics: Animal Structures; Animals; Anti-Bacterial Agents; beta-Lactams; Cefepime; Cephalosporins; Cricetina | 2014 |
Low-dose norfloxacin and ciprofloxacin therapy worsen leptospirosis in hamster.
Topics: Animals; Anti-Bacterial Agents; Bacterial Load; Biopsy; Ciprofloxacin; Cricetinae; Cytokines; Diseas | 2017 |