Assay ID | Title | Year | Journal | Article |
AID65380 | In vitro antibacterial activity against Enterococcus faecalis A9809 | 1992 | Journal of medicinal chemistry, Jul-24, Volume: 35, Issue:15
| Fluoronaphthyridines as antibacterial agents. 6. Synthesis and structure-activity relationships of new chiral 7-(1-, 3-, 4-, and 6-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)naphthyridine analogues of 7-[(1R,4R)-2,5- diazabicyclo[2.2.1]heptan-2-yl]-1-(1,1- |
AID140680 | Compound was evaluated in vivo in urine sample collected over 24 hours for its concentration after 40 mg/kg peroral administration to mice | 1991 | Journal of medicinal chemistry, Jan, Volume: 34, Issue:1
| Fluoronaphthyridines and -quinolones as antibacterial agents. 3. Synthesis and structure-activity relationships of new 1-(1,1-dimethyl-2-fluoroethyl), 1-[1-methyl-1-(fluoromethyl)-2-fluoroethyl], and 1-[1,1-(difluoromethyl)-2-fluoroethyl] substituted deri |
AID70286 | Efficacy on systematic infections against Escherichia coli A 15119 after oral administration in mice | 1990 | Journal of medicinal chemistry, May, Volume: 33, Issue:5
| Fluoronaphthyridines and quinolones as antibacterial agents. 2. Synthesis and structure-activity relationships of new 1-tert-butyl 7-substituted derivatives. |
AID140679 | Compound was evaluated in vivo in urine sample collected over 24 hours for its concentration after 40 mg/kg intramuscular administration to mice | 1991 | Journal of medicinal chemistry, Jan, Volume: 34, Issue:1
| Fluoronaphthyridines and -quinolones as antibacterial agents. 3. Synthesis and structure-activity relationships of new 1-(1,1-dimethyl-2-fluoroethyl), 1-[1-methyl-1-(fluoromethyl)-2-fluoroethyl], and 1-[1,1-(difluoromethyl)-2-fluoroethyl] substituted deri |
AID68843 | In vitro minimum inhibitory concentration (MIC) against Escherichia coli A 15119 at 37 degrees C for 18 h. | 1990 | Journal of medicinal chemistry, May, Volume: 33, Issue:5
| Fluoronaphthyridines and quinolones as antibacterial agents. 2. Synthesis and structure-activity relationships of new 1-tert-butyl 7-substituted derivatives. |
AID23631 | Plasma half-life after peroral administration to mice | 1992 | Journal of medicinal chemistry, Jul-24, Volume: 35, Issue:15
| Fluoronaphthyridines as antibacterial agents. 6. Synthesis and structure-activity relationships of new chiral 7-(1-, 3-, 4-, and 6-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)naphthyridine analogues of 7-[(1R,4R)-2,5- diazabicyclo[2.2.1]heptan-2-yl]-1-(1,1- |
AID134551 | Compound was tested for its acute toxicity after peroral(po) administration to OF1-strain of female Swiss mice. | 1991 | Journal of medicinal chemistry, Jan, Volume: 34, Issue:1
| Fluoronaphthyridines and -quinolones as antibacterial agents. 3. Synthesis and structure-activity relationships of new 1-(1,1-dimethyl-2-fluoroethyl), 1-[1-methyl-1-(fluoromethyl)-2-fluoroethyl], and 1-[1,1-(difluoromethyl)-2-fluoroethyl] substituted deri |
AID205831 | In vitro antibacterial activity (minimum inhibitory concentration, MIC) against Staphylococcus aureus A 9537. | 1991 | Journal of medicinal chemistry, Jan, Volume: 34, Issue:1
| Fluoronaphthyridines and -quinolones as antibacterial agents. 3. Synthesis and structure-activity relationships of new 1-(1,1-dimethyl-2-fluoroethyl), 1-[1-methyl-1-(fluoromethyl)-2-fluoroethyl], and 1-[1,1-(difluoromethyl)-2-fluoroethyl] substituted deri |
AID134566 | Dose to protect 50% of mice from lethal infection after intravenous administration | 1990 | Journal of medicinal chemistry, May, Volume: 33, Issue:5
| Fluoronaphthyridines and quinolones as antibacterial agents. 2. Synthesis and structure-activity relationships of new 1-tert-butyl 7-substituted derivatives. |
AID222227 | In vivo efficacy on systemic infections caused by Escherichia coli A15119 in mice after peroral administration | 1992 | Journal of medicinal chemistry, Jul-24, Volume: 35, Issue:15
| Fluoronaphthyridines as antibacterial agents. 6. Synthesis and structure-activity relationships of new chiral 7-(1-, 3-, 4-, and 6-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)naphthyridine analogues of 7-[(1R,4R)-2,5- diazabicyclo[2.2.1]heptan-2-yl]-1-(1,1- |
AID125256 | In vitro antibacterial activity against Morganella morganii A 15153 | 1991 | Journal of medicinal chemistry, Jan, Volume: 34, Issue:1
| Fluoronaphthyridines and -quinolones as antibacterial agents. 3. Synthesis and structure-activity relationships of new 1-(1,1-dimethyl-2-fluoroethyl), 1-[1-methyl-1-(fluoromethyl)-2-fluoroethyl], and 1-[1,1-(difluoromethyl)-2-fluoroethyl] substituted deri |
AID13549 | Area under curve measured as conc vs time after intravenous administration to mice. | 1992 | Journal of medicinal chemistry, Jul-24, Volume: 35, Issue:15
| Fluoronaphthyridines as antibacterial agents. 6. Synthesis and structure-activity relationships of new chiral 7-(1-, 3-, 4-, and 6-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)naphthyridine analogues of 7-[(1R,4R)-2,5- diazabicyclo[2.2.1]heptan-2-yl]-1-(1,1- |
AID23164 | Half-life time determined against Bacillus subtilis ATCC 6633 after oral administration in dog(25 mg/kg) | 1990 | Journal of medicinal chemistry, May, Volume: 33, Issue:5
| Fluoronaphthyridines and quinolones as antibacterial agents. 2. Synthesis and structure-activity relationships of new 1-tert-butyl 7-substituted derivatives. |
AID27357 | Acute toxicity after intravenous administration to mice | 1992 | Journal of medicinal chemistry, Jul-24, Volume: 35, Issue:15
| Fluoronaphthyridines as antibacterial agents. 6. Synthesis and structure-activity relationships of new chiral 7-(1-, 3-, 4-, and 6-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)naphthyridine analogues of 7-[(1R,4R)-2,5- diazabicyclo[2.2.1]heptan-2-yl]-1-(1,1- |
AID23630 | Plasma half-life after intravenous administration to mice | 1992 | Journal of medicinal chemistry, Jul-24, Volume: 35, Issue:15
| Fluoronaphthyridines as antibacterial agents. 6. Synthesis and structure-activity relationships of new chiral 7-(1-, 3-, 4-, and 6-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)naphthyridine analogues of 7-[(1R,4R)-2,5- diazabicyclo[2.2.1]heptan-2-yl]-1-(1,1- |
AID62811 | Compound was evaluated in vivo in urine sample collected over 24 hours for its concentration after 40 mg/kg peroral administration to dogs. | 1991 | Journal of medicinal chemistry, Jan, Volume: 34, Issue:1
| Fluoronaphthyridines and -quinolones as antibacterial agents. 3. Synthesis and structure-activity relationships of new 1-(1,1-dimethyl-2-fluoroethyl), 1-[1-methyl-1-(fluoromethyl)-2-fluoroethyl], and 1-[1,1-(difluoromethyl)-2-fluoroethyl] substituted deri |
AID206937 | Compound was tested for the dose to protect 50% of mice from lethal infection against Staphylococcus aureus A 9606 after peroral administration to OF1-strain of female Swiss mice. | 1991 | Journal of medicinal chemistry, Jan, Volume: 34, Issue:1
| Fluoronaphthyridines and -quinolones as antibacterial agents. 3. Synthesis and structure-activity relationships of new 1-(1,1-dimethyl-2-fluoroethyl), 1-[1-methyl-1-(fluoromethyl)-2-fluoroethyl], and 1-[1,1-(difluoromethyl)-2-fluoroethyl] substituted deri |
AID63901 | In vitro minimum inhibitory concentration (MIC) against Enterobacter cloacae A 9656 at 37 degrees C for 18 h. | 1990 | Journal of medicinal chemistry, May, Volume: 33, Issue:5
| Fluoronaphthyridines and quinolones as antibacterial agents. 2. Synthesis and structure-activity relationships of new 1-tert-butyl 7-substituted derivatives. |
AID70591 | In vitro antibacterial activity against Escherichia coli A 15119 | 1991 | Journal of medicinal chemistry, Jan, Volume: 34, Issue:1
| Fluoronaphthyridines and -quinolones as antibacterial agents. 3. Synthesis and structure-activity relationships of new 1-(1,1-dimethyl-2-fluoroethyl), 1-[1-methyl-1-(fluoromethyl)-2-fluoroethyl], and 1-[1,1-(difluoromethyl)-2-fluoroethyl] substituted deri |
AID27358 | Acute toxicity after peroral administration to mice | 1992 | Journal of medicinal chemistry, Jul-24, Volume: 35, Issue:15
| Fluoronaphthyridines as antibacterial agents. 6. Synthesis and structure-activity relationships of new chiral 7-(1-, 3-, 4-, and 6-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)naphthyridine analogues of 7-[(1R,4R)-2,5- diazabicyclo[2.2.1]heptan-2-yl]-1-(1,1- |
AID64383 | In vitro minimum inhibitory concentration (MIC) against Enterococcus faecium A 24885 at 37 degrees C for 18 h. | 1990 | Journal of medicinal chemistry, May, Volume: 33, Issue:5
| Fluoronaphthyridines and quinolones as antibacterial agents. 2. Synthesis and structure-activity relationships of new 1-tert-butyl 7-substituted derivatives. |
AID210201 | In vitro antibacterial activity against Streptococcus pneumoniae A 9585 | 1991 | Journal of medicinal chemistry, Jan, Volume: 34, Issue:1
| Fluoronaphthyridines and -quinolones as antibacterial agents. 3. Synthesis and structure-activity relationships of new 1-(1,1-dimethyl-2-fluoroethyl), 1-[1-methyl-1-(fluoromethyl)-2-fluoroethyl], and 1-[1,1-(difluoromethyl)-2-fluoroethyl] substituted deri |
AID64910 | In vitro antibacterial activity against Escherichia coli A15119 | 1992 | Journal of medicinal chemistry, Jul-24, Volume: 35, Issue:15
| Fluoronaphthyridines as antibacterial agents. 6. Synthesis and structure-activity relationships of new chiral 7-(1-, 3-, 4-, and 6-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)naphthyridine analogues of 7-[(1R,4R)-2,5- diazabicyclo[2.2.1]heptan-2-yl]-1-(1,1- |
AID23554 | Solubility (water, 22C, pH 7.2) | 1992 | Journal of medicinal chemistry, Jul-24, Volume: 35, Issue:15
| Fluoronaphthyridines as antibacterial agents. 6. Synthesis and structure-activity relationships of new chiral 7-(1-, 3-, 4-, and 6-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)naphthyridine analogues of 7-[(1R,4R)-2,5- diazabicyclo[2.2.1]heptan-2-yl]-1-(1,1- |
AID152307 | In vitro antibacterial activity against Proteus mirabilis A9900 | 1992 | Journal of medicinal chemistry, Jul-24, Volume: 35, Issue:15
| Fluoronaphthyridines as antibacterial agents. 6. Synthesis and structure-activity relationships of new chiral 7-(1-, 3-, 4-, and 6-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)naphthyridine analogues of 7-[(1R,4R)-2,5- diazabicyclo[2.2.1]heptan-2-yl]-1-(1,1- |
AID222234 | In vivo efficacy on systemic infections caused by Streptococcus pneumoniae A9585 in mice after peroral administration | 1992 | Journal of medicinal chemistry, Jul-24, Volume: 35, Issue:15
| Fluoronaphthyridines as antibacterial agents. 6. Synthesis and structure-activity relationships of new chiral 7-(1-, 3-, 4-, and 6-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)naphthyridine analogues of 7-[(1R,4R)-2,5- diazabicyclo[2.2.1]heptan-2-yl]-1-(1,1- |
AID164733 | Compound was tested in vitro for its antibacterial activity (minimum inhibitory concentration, MIC) against Pseudomonas aeruginosa A 9843 | 1991 | Journal of medicinal chemistry, Jan, Volume: 34, Issue:1
| Fluoronaphthyridines and -quinolones as antibacterial agents. 3. Synthesis and structure-activity relationships of new 1-(1,1-dimethyl-2-fluoroethyl), 1-[1-methyl-1-(fluoromethyl)-2-fluoroethyl], and 1-[1,1-(difluoromethyl)-2-fluoroethyl] substituted deri |
AID21159 | Percent urinary recovery in 24 hr after peroral administration to mice | 1992 | Journal of medicinal chemistry, Jul-24, Volume: 35, Issue:15
| Fluoronaphthyridines as antibacterial agents. 6. Synthesis and structure-activity relationships of new chiral 7-(1-, 3-, 4-, and 6-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)naphthyridine analogues of 7-[(1R,4R)-2,5- diazabicyclo[2.2.1]heptan-2-yl]-1-(1,1- |
AID201261 | In vitro antibacterial activity against Staphylococcus aureus A9537 | 1992 | Journal of medicinal chemistry, Jul-24, Volume: 35, Issue:15
| Fluoronaphthyridines as antibacterial agents. 6. Synthesis and structure-activity relationships of new chiral 7-(1-, 3-, 4-, and 6-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)naphthyridine analogues of 7-[(1R,4R)-2,5- diazabicyclo[2.2.1]heptan-2-yl]-1-(1,1- |
AID222231 | In vivo efficacy on systemic infections caused by Staphylococcus aureus A15090 in mice after intramuscular administration | 1992 | Journal of medicinal chemistry, Jul-24, Volume: 35, Issue:15
| Fluoronaphthyridines as antibacterial agents. 6. Synthesis and structure-activity relationships of new chiral 7-(1-, 3-, 4-, and 6-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)naphthyridine analogues of 7-[(1R,4R)-2,5- diazabicyclo[2.2.1]heptan-2-yl]-1-(1,1- |
AID202101 | In vitro antibacterial activity against Streptococcus pneumoniae A9585. | 1992 | Journal of medicinal chemistry, Jul-24, Volume: 35, Issue:15
| Fluoronaphthyridines as antibacterial agents. 6. Synthesis and structure-activity relationships of new chiral 7-(1-, 3-, 4-, and 6-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)naphthyridine analogues of 7-[(1R,4R)-2,5- diazabicyclo[2.2.1]heptan-2-yl]-1-(1,1- |
AID205394 | In vitro antibacterial activity (minimum inhibitory concentration) against Serratia marcescens A 20019. | 1991 | Journal of medicinal chemistry, Jan, Volume: 34, Issue:1
| Fluoronaphthyridines and -quinolones as antibacterial agents. 3. Synthesis and structure-activity relationships of new 1-(1,1-dimethyl-2-fluoroethyl), 1-[1-methyl-1-(fluoromethyl)-2-fluoroethyl], and 1-[1,1-(difluoromethyl)-2-fluoroethyl] substituted deri |
AID222229 | In vivo efficacy on systemic infections caused by Pseudomonas aeruginosa A9843 in mice after intramuscular administration | 1992 | Journal of medicinal chemistry, Jul-24, Volume: 35, Issue:15
| Fluoronaphthyridines as antibacterial agents. 6. Synthesis and structure-activity relationships of new chiral 7-(1-, 3-, 4-, and 6-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)naphthyridine analogues of 7-[(1R,4R)-2,5- diazabicyclo[2.2.1]heptan-2-yl]-1-(1,1- |
AID68180 | In vitro antibacterial activity against Enterobacter cloacae A 9656 | 1991 | Journal of medicinal chemistry, Jan, Volume: 34, Issue:1
| Fluoronaphthyridines and -quinolones as antibacterial agents. 3. Synthesis and structure-activity relationships of new 1-(1,1-dimethyl-2-fluoroethyl), 1-[1-methyl-1-(fluoromethyl)-2-fluoroethyl], and 1-[1,1-(difluoromethyl)-2-fluoroethyl] substituted deri |
AID13689 | Compound was evaluated in vivo in blood samples from the orbital sinus for its concentration after a peroral administration 40 mg/kg in mice | 1991 | Journal of medicinal chemistry, Jan, Volume: 34, Issue:1
| Fluoronaphthyridines and -quinolones as antibacterial agents. 3. Synthesis and structure-activity relationships of new 1-(1,1-dimethyl-2-fluoroethyl), 1-[1-methyl-1-(fluoromethyl)-2-fluoroethyl], and 1-[1,1-(difluoromethyl)-2-fluoroethyl] substituted deri |
AID10719 | Area under the concentration/ time determined against Bacillus subtilis ATCC 6633 after oral administration in dog(25 mg/kg) | 1990 | Journal of medicinal chemistry, May, Volume: 33, Issue:5
| Fluoronaphthyridines and quinolones as antibacterial agents. 2. Synthesis and structure-activity relationships of new 1-tert-butyl 7-substituted derivatives. |
AID11145 | Compound was evaluated in vivo in for its concentration using Area under the time-concentration curve after 40 mg/kg peroral administration to dogs. | 1991 | Journal of medicinal chemistry, Jan, Volume: 34, Issue:1
| Fluoronaphthyridines and -quinolones as antibacterial agents. 3. Synthesis and structure-activity relationships of new 1-(1,1-dimethyl-2-fluoroethyl), 1-[1-methyl-1-(fluoromethyl)-2-fluoroethyl], and 1-[1,1-(difluoromethyl)-2-fluoroethyl] substituted deri |
AID38483 | In vitro antibacterial activity against Bacteroides fragilis A-22,862 | 1992 | Journal of medicinal chemistry, Jul-24, Volume: 35, Issue:15
| Fluoronaphthyridines as antibacterial agents. 6. Synthesis and structure-activity relationships of new chiral 7-(1-, 3-, 4-, and 6-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)naphthyridine analogues of 7-[(1R,4R)-2,5- diazabicyclo[2.2.1]heptan-2-yl]-1-(1,1- |
AID21165 | percent urinary recovery in 24 hr after intravenous administration to mice | 1992 | Journal of medicinal chemistry, Jul-24, Volume: 35, Issue:15
| Fluoronaphthyridines as antibacterial agents. 6. Synthesis and structure-activity relationships of new chiral 7-(1-, 3-, 4-, and 6-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)naphthyridine analogues of 7-[(1R,4R)-2,5- diazabicyclo[2.2.1]heptan-2-yl]-1-(1,1- |
AID24518 | Compound was evaluated in vivo in blood samples from the orbital sinus for its half life after 40 mg/kg of peroral administration in mice. | 1991 | Journal of medicinal chemistry, Jan, Volume: 34, Issue:1
| Fluoronaphthyridines and -quinolones as antibacterial agents. 3. Synthesis and structure-activity relationships of new 1-(1,1-dimethyl-2-fluoroethyl), 1-[1-methyl-1-(fluoromethyl)-2-fluoroethyl], and 1-[1,1-(difluoromethyl)-2-fluoroethyl] substituted deri |
AID24516 | Compound was evaluated in vivo for its half life after 40 mg/kg of peroral administration in dogs. | 1991 | Journal of medicinal chemistry, Jan, Volume: 34, Issue:1
| Fluoronaphthyridines and -quinolones as antibacterial agents. 3. Synthesis and structure-activity relationships of new 1-(1,1-dimethyl-2-fluoroethyl), 1-[1-methyl-1-(fluoromethyl)-2-fluoroethyl], and 1-[1,1-(difluoromethyl)-2-fluoroethyl] substituted deri |
AID222230 | In vivo efficacy on systemic infections caused by Pseudomonas aeruginosa A9843 in mice after peroral administration | 1992 | Journal of medicinal chemistry, Jul-24, Volume: 35, Issue:15
| Fluoronaphthyridines as antibacterial agents. 6. Synthesis and structure-activity relationships of new chiral 7-(1-, 3-, 4-, and 6-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)naphthyridine analogues of 7-[(1R,4R)-2,5- diazabicyclo[2.2.1]heptan-2-yl]-1-(1,1- |
AID103861 | In vitro antibacterial activity against Morganella morganii A15153 | 1992 | Journal of medicinal chemistry, Jul-24, Volume: 35, Issue:15
| Fluoronaphthyridines as antibacterial agents. 6. Synthesis and structure-activity relationships of new chiral 7-(1-, 3-, 4-, and 6-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)naphthyridine analogues of 7-[(1R,4R)-2,5- diazabicyclo[2.2.1]heptan-2-yl]-1-(1,1- |
AID95533 | In vitro antibacterial activity against Klebsiella pneumoniae A 9664 | 1991 | Journal of medicinal chemistry, Jan, Volume: 34, Issue:1
| Fluoronaphthyridines and -quinolones as antibacterial agents. 3. Synthesis and structure-activity relationships of new 1-(1,1-dimethyl-2-fluoroethyl), 1-[1-methyl-1-(fluoromethyl)-2-fluoroethyl], and 1-[1,1-(difluoromethyl)-2-fluoroethyl] substituted deri |
AID40339 | Compound was tested in vitro for its antibacterial activity (minimum inhibitory concentration) against Bacteroides fragilis A 22862. | 1991 | Journal of medicinal chemistry, Jan, Volume: 34, Issue:1
| Fluoronaphthyridines and -quinolones as antibacterial agents. 3. Synthesis and structure-activity relationships of new 1-(1,1-dimethyl-2-fluoroethyl), 1-[1-methyl-1-(fluoromethyl)-2-fluoroethyl], and 1-[1,1-(difluoromethyl)-2-fluoroethyl] substituted deri |
AID20933 | Compound was tested for its solubility at 20 degrees C and isoelectric pH. | 1991 | Journal of medicinal chemistry, Jan, Volume: 34, Issue:1
| Fluoronaphthyridines and -quinolones as antibacterial agents. 3. Synthesis and structure-activity relationships of new 1-(1,1-dimethyl-2-fluoroethyl), 1-[1-methyl-1-(fluoromethyl)-2-fluoroethyl], and 1-[1,1-(difluoromethyl)-2-fluoroethyl] substituted deri |
AID94069 | Efficacy on systematic infections against Klebsiella pneumoniae A 9664 after oral administration in mice | 1990 | Journal of medicinal chemistry, May, Volume: 33, Issue:5
| Fluoronaphthyridines and quinolones as antibacterial agents. 2. Synthesis and structure-activity relationships of new 1-tert-butyl 7-substituted derivatives. |
AID163608 | Compound was tested for the dose to protect 50% of mice from lethal infection against Pseudomonas aeruginosa A9843 after peroral administration to OF1-strain of female Swiss mice. | 1991 | Journal of medicinal chemistry, Jan, Volume: 34, Issue:1
| Fluoronaphthyridines and -quinolones as antibacterial agents. 3. Synthesis and structure-activity relationships of new 1-(1,1-dimethyl-2-fluoroethyl), 1-[1-methyl-1-(fluoromethyl)-2-fluoroethyl], and 1-[1,1-(difluoromethyl)-2-fluoroethyl] substituted deri |
AID134569 | Dose to protect 50% of mice from lethal infection after peroral administration. | 1990 | Journal of medicinal chemistry, May, Volume: 33, Issue:5
| Fluoronaphthyridines and quinolones as antibacterial agents. 2. Synthesis and structure-activity relationships of new 1-tert-butyl 7-substituted derivatives. |
AID96418 | In vitro minimum inhibitory concentration (MIC) against Klebsiella pneumoniae A 9664 at 37 degrees C for 18 h | 1990 | Journal of medicinal chemistry, May, Volume: 33, Issue:5
| Fluoronaphthyridines and quinolones as antibacterial agents. 2. Synthesis and structure-activity relationships of new 1-tert-butyl 7-substituted derivatives. |
AID11144 | Compound was evaluated in vivo in blood samples from the orbital sinus for its concentration using Area under the time-concentration curve after 40 mg/kg peroral administration to mice | 1991 | Journal of medicinal chemistry, Jan, Volume: 34, Issue:1
| Fluoronaphthyridines and -quinolones as antibacterial agents. 3. Synthesis and structure-activity relationships of new 1-(1,1-dimethyl-2-fluoroethyl), 1-[1-methyl-1-(fluoromethyl)-2-fluoroethyl], and 1-[1,1-(difluoromethyl)-2-fluoroethyl] substituted deri |
AID24186 | Partition coefficient (logD) | 1992 | Journal of medicinal chemistry, Jul-24, Volume: 35, Issue:15
| Fluoronaphthyridines as antibacterial agents. 6. Synthesis and structure-activity relationships of new chiral 7-(1-, 3-, 4-, and 6-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)naphthyridine analogues of 7-[(1R,4R)-2,5- diazabicyclo[2.2.1]heptan-2-yl]-1-(1,1- |
AID13900 | Maximum concentration determined against Bacillus subtilis ATCC 6633 after oral administration in dog(25 mg/kg) | 1990 | Journal of medicinal chemistry, May, Volume: 33, Issue:5
| Fluoronaphthyridines and quinolones as antibacterial agents. 2. Synthesis and structure-activity relationships of new 1-tert-butyl 7-substituted derivatives. |
AID21157 | Percent of dose administarted, for urinary recovery determined against Bacillus subtilis ATCC 6633 after oral administration in dog(25 mg/kg) | 1990 | Journal of medicinal chemistry, May, Volume: 33, Issue:5
| Fluoronaphthyridines and quinolones as antibacterial agents. 2. Synthesis and structure-activity relationships of new 1-tert-butyl 7-substituted derivatives. |
AID222226 | In vivo efficacy on systemic infections caused by Escherichia coli A15119 in mice after intramuscular administration | 1992 | Journal of medicinal chemistry, Jul-24, Volume: 35, Issue:15
| Fluoronaphthyridines as antibacterial agents. 6. Synthesis and structure-activity relationships of new chiral 7-(1-, 3-, 4-, and 6-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)naphthyridine analogues of 7-[(1R,4R)-2,5- diazabicyclo[2.2.1]heptan-2-yl]-1-(1,1- |
AID14289 | Peak concentration in blood after peroral administration to mice | 1992 | Journal of medicinal chemistry, Jul-24, Volume: 35, Issue:15
| Fluoronaphthyridines as antibacterial agents. 6. Synthesis and structure-activity relationships of new chiral 7-(1-, 3-, 4-, and 6-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)naphthyridine analogues of 7-[(1R,4R)-2,5- diazabicyclo[2.2.1]heptan-2-yl]-1-(1,1- |
AID94297 | In vitro antibacterial activity against Klebsiella pneumoniae A9664 | 1992 | Journal of medicinal chemistry, Jul-24, Volume: 35, Issue:15
| Fluoronaphthyridines as antibacterial agents. 6. Synthesis and structure-activity relationships of new chiral 7-(1-, 3-, 4-, and 6-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)naphthyridine analogues of 7-[(1R,4R)-2,5- diazabicyclo[2.2.1]heptan-2-yl]-1-(1,1- |
AID197849 | Efficacy on systematic infections against Staphylococcus aureus A 9537 after oral administration in mice | 1990 | Journal of medicinal chemistry, May, Volume: 33, Issue:5
| Fluoronaphthyridines and quinolones as antibacterial agents. 2. Synthesis and structure-activity relationships of new 1-tert-butyl 7-substituted derivatives. |
AID205830 | In vitro antibacterial activity against Staphylococcus aureus A 24227 | 1991 | Journal of medicinal chemistry, Jan, Volume: 34, Issue:1
| Fluoronaphthyridines and -quinolones as antibacterial agents. 3. Synthesis and structure-activity relationships of new 1-(1,1-dimethyl-2-fluoroethyl), 1-[1-methyl-1-(fluoromethyl)-2-fluoroethyl], and 1-[1,1-(difluoromethyl)-2-fluoroethyl] substituted deri |
AID67228 | In vitro antibacterial activity against Enterococcus faecalis A 9809 | 1991 | Journal of medicinal chemistry, Jan, Volume: 34, Issue:1
| Fluoronaphthyridines and -quinolones as antibacterial agents. 3. Synthesis and structure-activity relationships of new 1-(1,1-dimethyl-2-fluoroethyl), 1-[1-methyl-1-(fluoromethyl)-2-fluoroethyl], and 1-[1,1-(difluoromethyl)-2-fluoroethyl] substituted deri |
AID14288 | Peak concentration in blood after intravenous administration to mice | 1992 | Journal of medicinal chemistry, Jul-24, Volume: 35, Issue:15
| Fluoronaphthyridines as antibacterial agents. 6. Synthesis and structure-activity relationships of new chiral 7-(1-, 3-, 4-, and 6-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)naphthyridine analogues of 7-[(1R,4R)-2,5- diazabicyclo[2.2.1]heptan-2-yl]-1-(1,1- |
AID206690 | Compound was tested for the dose to protect 50% of mice from lethal infection against Streptococcus pneumoniae after peroral administration to OF1-strain of female Swiss mice. | 1991 | Journal of medicinal chemistry, Jan, Volume: 34, Issue:1
| Fluoronaphthyridines and -quinolones as antibacterial agents. 3. Synthesis and structure-activity relationships of new 1-(1,1-dimethyl-2-fluoroethyl), 1-[1-methyl-1-(fluoromethyl)-2-fluoroethyl], and 1-[1,1-(difluoromethyl)-2-fluoroethyl] substituted deri |
AID222232 | In vivo efficacy on systemic infections caused by Staphylococcus aureus A15090 in mice after peroral administration | 1992 | Journal of medicinal chemistry, Jul-24, Volume: 35, Issue:15
| Fluoronaphthyridines as antibacterial agents. 6. Synthesis and structure-activity relationships of new chiral 7-(1-, 3-, 4-, and 6-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)naphthyridine analogues of 7-[(1R,4R)-2,5- diazabicyclo[2.2.1]heptan-2-yl]-1-(1,1- |
AID11143 | Compound was evaluated in vivo in blood samples from the orbital sinus for its concentration using Area under the time-concentration curve after 40 mg/kg intramuscular administration to mice | 1991 | Journal of medicinal chemistry, Jan, Volume: 34, Issue:1
| Fluoronaphthyridines and -quinolones as antibacterial agents. 3. Synthesis and structure-activity relationships of new 1-(1,1-dimethyl-2-fluoroethyl), 1-[1-methyl-1-(fluoromethyl)-2-fluoroethyl], and 1-[1,1-(difluoromethyl)-2-fluoroethyl] substituted deri |
AID13687 | Compound was evaluated in vivo for its concentration after a peroral administration 40 mg/kg in dogs. | 1991 | Journal of medicinal chemistry, Jan, Volume: 34, Issue:1
| Fluoronaphthyridines and -quinolones as antibacterial agents. 3. Synthesis and structure-activity relationships of new 1-(1,1-dimethyl-2-fluoroethyl), 1-[1-methyl-1-(fluoromethyl)-2-fluoroethyl], and 1-[1,1-(difluoromethyl)-2-fluoroethyl] substituted deri |
AID222233 | In vivo efficacy on systemic infections caused by Streptococcus pneumoniae A9585 in mice after intramuscular administration | 1992 | Journal of medicinal chemistry, Jul-24, Volume: 35, Issue:15
| Fluoronaphthyridines as antibacterial agents. 6. Synthesis and structure-activity relationships of new chiral 7-(1-, 3-, 4-, and 6-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)naphthyridine analogues of 7-[(1R,4R)-2,5- diazabicyclo[2.2.1]heptan-2-yl]-1-(1,1- |
AID64256 | In vitro minimum inhibitory concentration (MIC) against Enterococcus faecalis A 9808 at 37 degrees C for 18 h. | 1990 | Journal of medicinal chemistry, May, Volume: 33, Issue:5
| Fluoronaphthyridines and quinolones as antibacterial agents. 2. Synthesis and structure-activity relationships of new 1-tert-butyl 7-substituted derivatives. |
AID162744 | In vitro antibacterial activity (minimum inhibitory concentration, MIC) against Proteus mirabilis A 9900 | 1991 | Journal of medicinal chemistry, Jan, Volume: 34, Issue:1
| Fluoronaphthyridines and -quinolones as antibacterial agents. 3. Synthesis and structure-activity relationships of new 1-(1,1-dimethyl-2-fluoroethyl), 1-[1-methyl-1-(fluoromethyl)-2-fluoroethyl], and 1-[1,1-(difluoromethyl)-2-fluoroethyl] substituted deri |
AID125278 | In vitro minimum inhibitory concentration (MIC) against Morganella morganii A 15153 at 37 degrees C for 18 h. | 1990 | Journal of medicinal chemistry, May, Volume: 33, Issue:5
| Fluoronaphthyridines and quinolones as antibacterial agents. 2. Synthesis and structure-activity relationships of new 1-tert-butyl 7-substituted derivatives. |
AID201746 | In vitro antibacterial activity against Serratia marcescens A20019 | 1992 | Journal of medicinal chemistry, Jul-24, Volume: 35, Issue:15
| Fluoronaphthyridines as antibacterial agents. 6. Synthesis and structure-activity relationships of new chiral 7-(1-, 3-, 4-, and 6-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)naphthyridine analogues of 7-[(1R,4R)-2,5- diazabicyclo[2.2.1]heptan-2-yl]-1-(1,1- |
AID150902 | In vitro minimum inhibitory concentration (MIC) against Pseudomonas aeruginosa A 9843 at 37 degree C for 18 h | 1990 | Journal of medicinal chemistry, May, Volume: 33, Issue:5
| Fluoronaphthyridines and quinolones as antibacterial agents. 2. Synthesis and structure-activity relationships of new 1-tert-butyl 7-substituted derivatives. |
AID150907 | Efficacy on systematic infections against Pseudomonas aeruginosa A 9843 after oral administration in mice | 1990 | Journal of medicinal chemistry, May, Volume: 33, Issue:5
| Fluoronaphthyridines and quinolones as antibacterial agents. 2. Synthesis and structure-activity relationships of new 1-tert-butyl 7-substituted derivatives. |
AID13550 | Area under curve measured as conc vs time after peroral administration to mice. | 1992 | Journal of medicinal chemistry, Jul-24, Volume: 35, Issue:15
| Fluoronaphthyridines as antibacterial agents. 6. Synthesis and structure-activity relationships of new chiral 7-(1-, 3-, 4-, and 6-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)naphthyridine analogues of 7-[(1R,4R)-2,5- diazabicyclo[2.2.1]heptan-2-yl]-1-(1,1- |
AID134550 | Compound was tested for its acute toxicity after intravenous (iv) administration to OF1-strain of female Swiss mice. | 1991 | Journal of medicinal chemistry, Jan, Volume: 34, Issue:1
| Fluoronaphthyridines and -quinolones as antibacterial agents. 3. Synthesis and structure-activity relationships of new 1-(1,1-dimethyl-2-fluoroethyl), 1-[1-methyl-1-(fluoromethyl)-2-fluoroethyl], and 1-[1,1-(difluoromethyl)-2-fluoroethyl] substituted deri |
AID21967 | Tested for aqueous solubility | 1990 | Journal of medicinal chemistry, May, Volume: 33, Issue:5
| Fluoronaphthyridines and quinolones as antibacterial agents. 2. Synthesis and structure-activity relationships of new 1-tert-butyl 7-substituted derivatives. |
AID151545 | In vitro antibacterial activity against Pseudomonas aeruginosa A9843 | 1992 | Journal of medicinal chemistry, Jul-24, Volume: 35, Issue:15
| Fluoronaphthyridines as antibacterial agents. 6. Synthesis and structure-activity relationships of new chiral 7-(1-, 3-, 4-, and 6-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)naphthyridine analogues of 7-[(1R,4R)-2,5- diazabicyclo[2.2.1]heptan-2-yl]-1-(1,1- |
AID200257 | In vitro minimum inhibitory concentration (MIC) against Staphylococcus aureus Smith A 9537 at 37 degrees C for 18 hr | 1990 | Journal of medicinal chemistry, May, Volume: 33, Issue:5
| Fluoronaphthyridines and quinolones as antibacterial agents. 2. Synthesis and structure-activity relationships of new 1-tert-butyl 7-substituted derivatives. |
AID24517 | Compound was evaluated in vivo in blood samples from the orbital sinus for its half life after 40 mg/kg of intramuscular administration in mice. | 1991 | Journal of medicinal chemistry, Jan, Volume: 34, Issue:1
| Fluoronaphthyridines and -quinolones as antibacterial agents. 3. Synthesis and structure-activity relationships of new 1-(1,1-dimethyl-2-fluoroethyl), 1-[1-methyl-1-(fluoromethyl)-2-fluoroethyl], and 1-[1,1-(difluoromethyl)-2-fluoroethyl] substituted deri |
AID198156 | In vitro minimum inhibitory concentration (MIC) against Serratia marcescens A 20019 at 37 degrees C for 18 hr | 1990 | Journal of medicinal chemistry, May, Volume: 33, Issue:5
| Fluoronaphthyridines and quinolones as antibacterial agents. 2. Synthesis and structure-activity relationships of new 1-tert-butyl 7-substituted derivatives. |
AID64396 | In vitro antibacterial activity against Enterobacter cloacae A9656 | 1992 | Journal of medicinal chemistry, Jul-24, Volume: 35, Issue:15
| Fluoronaphthyridines as antibacterial agents. 6. Synthesis and structure-activity relationships of new chiral 7-(1-, 3-, 4-, and 6-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)naphthyridine analogues of 7-[(1R,4R)-2,5- diazabicyclo[2.2.1]heptan-2-yl]-1-(1,1- |
AID85970 | In vitro antibacterial activity against Haemophilus influenzae A 21515 | 1991 | Journal of medicinal chemistry, Jan, Volume: 34, Issue:1
| Fluoronaphthyridines and -quinolones as antibacterial agents. 3. Synthesis and structure-activity relationships of new 1-(1,1-dimethyl-2-fluoroethyl), 1-[1-methyl-1-(fluoromethyl)-2-fluoroethyl], and 1-[1,1-(difluoromethyl)-2-fluoroethyl] substituted deri |
AID13691 | Compound was evaluated in vivo in blood samples from the orbital sinus for its concentration after an intramuscular administration of 40 mg/kg in mice | 1991 | Journal of medicinal chemistry, Jan, Volume: 34, Issue:1
| Fluoronaphthyridines and -quinolones as antibacterial agents. 3. Synthesis and structure-activity relationships of new 1-(1,1-dimethyl-2-fluoroethyl), 1-[1-methyl-1-(fluoromethyl)-2-fluoroethyl], and 1-[1,1-(difluoromethyl)-2-fluoroethyl] substituted deri |
AID70281 | Compound was tested for the dose to protect 50% of mice from lethal infection against Escherichia coli A 15119 after peroral administration to OF1-strain of female Swiss mice. | 1991 | Journal of medicinal chemistry, Jan, Volume: 34, Issue:1
| Fluoronaphthyridines and -quinolones as antibacterial agents. 3. Synthesis and structure-activity relationships of new 1-(1,1-dimethyl-2-fluoroethyl), 1-[1-methyl-1-(fluoromethyl)-2-fluoroethyl], and 1-[1,1-(difluoromethyl)-2-fluoroethyl] substituted deri |
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |