Page last updated: 2024-12-08

bmy 40062

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth

Description

BMY 40062: structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID163995
CHEMBL ID98886
SCHEMBL ID9129484
MeSH IDM0168612

Synonyms (10)

Synonym
CHEMBL98886
brn 3656425
1,8-naphthyridine-3-carboxylic acid, 7-(2,5-diazabicyclo(2.2.1)hept-2-yl)-1-(1,1-dimethylethyl)-6-fluoro-1,4-dihydro-4-oxo-, (1r)-
1,8-naphthyridine-3-carboxylic acid, 1,4-dihydro-7-(2,5-diazabicyclo(2.2.1)hept-2-yl)-1-(1,1-dimethylethyl)-6-fluoro-4-oxo-, (1r)-
bmy 40062
1,8-naphthyridine-3-carboxylic acid, 7-[(1r,4r)-2,5-diazabicyclo[2.2.1]hept-2-yl]-1-(1,1-dimethylethyl)-6-fluoro-1,4-dihydro-4-oxo-
1-tert-butyl-7-[(1r,4r)-2,5-diazabicyclo[2.2.1]heptan-2-yl]-6-fluoro-4-oxo-1,8-naphthyridine-3-carboxylic acid
bmy-40062
7-(2,5-diazabicyclo(2.2.1)heptan-2-yl)-1-(1,1-dimethyl)ethyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid
SCHEMBL9129484

Research Excerpts

Bioavailability

ExcerptReferenceRelevance
" BMY 40062 exhibited longer half-life, higher maximum concentration in serum, greater area under the curve, and better bioavailability in mice after oral dosing than ciprofloxacin."( In vitro and in vivo antibacterial activities of BMY 40062, a new fluoronaphthyridone.
Desiderio, JV; Fung-Tomc, J; Kessler, RE; Tsai, YH; Warr, G, 1989
)
1.44

Dosage Studied

ExcerptRelevanceReference
" BMY 40062 exhibited longer half-life, higher maximum concentration in serum, greater area under the curve, and better bioavailability in mice after oral dosing than ciprofloxacin."( In vitro and in vivo antibacterial activities of BMY 40062, a new fluoronaphthyridone.
Desiderio, JV; Fung-Tomc, J; Kessler, RE; Tsai, YH; Warr, G, 1989
)
1.44
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (83)

Assay IDTitleYearJournalArticle
AID65380In vitro antibacterial activity against Enterococcus faecalis A98091992Journal of medicinal chemistry, Jul-24, Volume: 35, Issue:15
Fluoronaphthyridines as antibacterial agents. 6. Synthesis and structure-activity relationships of new chiral 7-(1-, 3-, 4-, and 6-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)naphthyridine analogues of 7-[(1R,4R)-2,5- diazabicyclo[2.2.1]heptan-2-yl]-1-(1,1-
AID140680Compound was evaluated in vivo in urine sample collected over 24 hours for its concentration after 40 mg/kg peroral administration to mice1991Journal of medicinal chemistry, Jan, Volume: 34, Issue:1
Fluoronaphthyridines and -quinolones as antibacterial agents. 3. Synthesis and structure-activity relationships of new 1-(1,1-dimethyl-2-fluoroethyl), 1-[1-methyl-1-(fluoromethyl)-2-fluoroethyl], and 1-[1,1-(difluoromethyl)-2-fluoroethyl] substituted deri
AID70286Efficacy on systematic infections against Escherichia coli A 15119 after oral administration in mice1990Journal of medicinal chemistry, May, Volume: 33, Issue:5
Fluoronaphthyridines and quinolones as antibacterial agents. 2. Synthesis and structure-activity relationships of new 1-tert-butyl 7-substituted derivatives.
AID140679Compound was evaluated in vivo in urine sample collected over 24 hours for its concentration after 40 mg/kg intramuscular administration to mice1991Journal of medicinal chemistry, Jan, Volume: 34, Issue:1
Fluoronaphthyridines and -quinolones as antibacterial agents. 3. Synthesis and structure-activity relationships of new 1-(1,1-dimethyl-2-fluoroethyl), 1-[1-methyl-1-(fluoromethyl)-2-fluoroethyl], and 1-[1,1-(difluoromethyl)-2-fluoroethyl] substituted deri
AID68843In vitro minimum inhibitory concentration (MIC) against Escherichia coli A 15119 at 37 degrees C for 18 h.1990Journal of medicinal chemistry, May, Volume: 33, Issue:5
Fluoronaphthyridines and quinolones as antibacterial agents. 2. Synthesis and structure-activity relationships of new 1-tert-butyl 7-substituted derivatives.
AID23631Plasma half-life after peroral administration to mice1992Journal of medicinal chemistry, Jul-24, Volume: 35, Issue:15
Fluoronaphthyridines as antibacterial agents. 6. Synthesis and structure-activity relationships of new chiral 7-(1-, 3-, 4-, and 6-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)naphthyridine analogues of 7-[(1R,4R)-2,5- diazabicyclo[2.2.1]heptan-2-yl]-1-(1,1-
AID134551Compound was tested for its acute toxicity after peroral(po) administration to OF1-strain of female Swiss mice.1991Journal of medicinal chemistry, Jan, Volume: 34, Issue:1
Fluoronaphthyridines and -quinolones as antibacterial agents. 3. Synthesis and structure-activity relationships of new 1-(1,1-dimethyl-2-fluoroethyl), 1-[1-methyl-1-(fluoromethyl)-2-fluoroethyl], and 1-[1,1-(difluoromethyl)-2-fluoroethyl] substituted deri
AID205831In vitro antibacterial activity (minimum inhibitory concentration, MIC) against Staphylococcus aureus A 9537.1991Journal of medicinal chemistry, Jan, Volume: 34, Issue:1
Fluoronaphthyridines and -quinolones as antibacterial agents. 3. Synthesis and structure-activity relationships of new 1-(1,1-dimethyl-2-fluoroethyl), 1-[1-methyl-1-(fluoromethyl)-2-fluoroethyl], and 1-[1,1-(difluoromethyl)-2-fluoroethyl] substituted deri
AID134566Dose to protect 50% of mice from lethal infection after intravenous administration1990Journal of medicinal chemistry, May, Volume: 33, Issue:5
Fluoronaphthyridines and quinolones as antibacterial agents. 2. Synthesis and structure-activity relationships of new 1-tert-butyl 7-substituted derivatives.
AID222227In vivo efficacy on systemic infections caused by Escherichia coli A15119 in mice after peroral administration1992Journal of medicinal chemistry, Jul-24, Volume: 35, Issue:15
Fluoronaphthyridines as antibacterial agents. 6. Synthesis and structure-activity relationships of new chiral 7-(1-, 3-, 4-, and 6-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)naphthyridine analogues of 7-[(1R,4R)-2,5- diazabicyclo[2.2.1]heptan-2-yl]-1-(1,1-
AID125256In vitro antibacterial activity against Morganella morganii A 151531991Journal of medicinal chemistry, Jan, Volume: 34, Issue:1
Fluoronaphthyridines and -quinolones as antibacterial agents. 3. Synthesis and structure-activity relationships of new 1-(1,1-dimethyl-2-fluoroethyl), 1-[1-methyl-1-(fluoromethyl)-2-fluoroethyl], and 1-[1,1-(difluoromethyl)-2-fluoroethyl] substituted deri
AID13549Area under curve measured as conc vs time after intravenous administration to mice.1992Journal of medicinal chemistry, Jul-24, Volume: 35, Issue:15
Fluoronaphthyridines as antibacterial agents. 6. Synthesis and structure-activity relationships of new chiral 7-(1-, 3-, 4-, and 6-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)naphthyridine analogues of 7-[(1R,4R)-2,5- diazabicyclo[2.2.1]heptan-2-yl]-1-(1,1-
AID23164Half-life time determined against Bacillus subtilis ATCC 6633 after oral administration in dog(25 mg/kg)1990Journal of medicinal chemistry, May, Volume: 33, Issue:5
Fluoronaphthyridines and quinolones as antibacterial agents. 2. Synthesis and structure-activity relationships of new 1-tert-butyl 7-substituted derivatives.
AID27357Acute toxicity after intravenous administration to mice1992Journal of medicinal chemistry, Jul-24, Volume: 35, Issue:15
Fluoronaphthyridines as antibacterial agents. 6. Synthesis and structure-activity relationships of new chiral 7-(1-, 3-, 4-, and 6-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)naphthyridine analogues of 7-[(1R,4R)-2,5- diazabicyclo[2.2.1]heptan-2-yl]-1-(1,1-
AID23630Plasma half-life after intravenous administration to mice1992Journal of medicinal chemistry, Jul-24, Volume: 35, Issue:15
Fluoronaphthyridines as antibacterial agents. 6. Synthesis and structure-activity relationships of new chiral 7-(1-, 3-, 4-, and 6-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)naphthyridine analogues of 7-[(1R,4R)-2,5- diazabicyclo[2.2.1]heptan-2-yl]-1-(1,1-
AID62811Compound was evaluated in vivo in urine sample collected over 24 hours for its concentration after 40 mg/kg peroral administration to dogs.1991Journal of medicinal chemistry, Jan, Volume: 34, Issue:1
Fluoronaphthyridines and -quinolones as antibacterial agents. 3. Synthesis and structure-activity relationships of new 1-(1,1-dimethyl-2-fluoroethyl), 1-[1-methyl-1-(fluoromethyl)-2-fluoroethyl], and 1-[1,1-(difluoromethyl)-2-fluoroethyl] substituted deri
AID206937Compound was tested for the dose to protect 50% of mice from lethal infection against Staphylococcus aureus A 9606 after peroral administration to OF1-strain of female Swiss mice.1991Journal of medicinal chemistry, Jan, Volume: 34, Issue:1
Fluoronaphthyridines and -quinolones as antibacterial agents. 3. Synthesis and structure-activity relationships of new 1-(1,1-dimethyl-2-fluoroethyl), 1-[1-methyl-1-(fluoromethyl)-2-fluoroethyl], and 1-[1,1-(difluoromethyl)-2-fluoroethyl] substituted deri
AID63901In vitro minimum inhibitory concentration (MIC) against Enterobacter cloacae A 9656 at 37 degrees C for 18 h.1990Journal of medicinal chemistry, May, Volume: 33, Issue:5
Fluoronaphthyridines and quinolones as antibacterial agents. 2. Synthesis and structure-activity relationships of new 1-tert-butyl 7-substituted derivatives.
AID70591In vitro antibacterial activity against Escherichia coli A 151191991Journal of medicinal chemistry, Jan, Volume: 34, Issue:1
Fluoronaphthyridines and -quinolones as antibacterial agents. 3. Synthesis and structure-activity relationships of new 1-(1,1-dimethyl-2-fluoroethyl), 1-[1-methyl-1-(fluoromethyl)-2-fluoroethyl], and 1-[1,1-(difluoromethyl)-2-fluoroethyl] substituted deri
AID27358Acute toxicity after peroral administration to mice1992Journal of medicinal chemistry, Jul-24, Volume: 35, Issue:15
Fluoronaphthyridines as antibacterial agents. 6. Synthesis and structure-activity relationships of new chiral 7-(1-, 3-, 4-, and 6-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)naphthyridine analogues of 7-[(1R,4R)-2,5- diazabicyclo[2.2.1]heptan-2-yl]-1-(1,1-
AID64383In vitro minimum inhibitory concentration (MIC) against Enterococcus faecium A 24885 at 37 degrees C for 18 h.1990Journal of medicinal chemistry, May, Volume: 33, Issue:5
Fluoronaphthyridines and quinolones as antibacterial agents. 2. Synthesis and structure-activity relationships of new 1-tert-butyl 7-substituted derivatives.
AID210201In vitro antibacterial activity against Streptococcus pneumoniae A 95851991Journal of medicinal chemistry, Jan, Volume: 34, Issue:1
Fluoronaphthyridines and -quinolones as antibacterial agents. 3. Synthesis and structure-activity relationships of new 1-(1,1-dimethyl-2-fluoroethyl), 1-[1-methyl-1-(fluoromethyl)-2-fluoroethyl], and 1-[1,1-(difluoromethyl)-2-fluoroethyl] substituted deri
AID64910In vitro antibacterial activity against Escherichia coli A151191992Journal of medicinal chemistry, Jul-24, Volume: 35, Issue:15
Fluoronaphthyridines as antibacterial agents. 6. Synthesis and structure-activity relationships of new chiral 7-(1-, 3-, 4-, and 6-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)naphthyridine analogues of 7-[(1R,4R)-2,5- diazabicyclo[2.2.1]heptan-2-yl]-1-(1,1-
AID23554Solubility (water, 22C, pH 7.2)1992Journal of medicinal chemistry, Jul-24, Volume: 35, Issue:15
Fluoronaphthyridines as antibacterial agents. 6. Synthesis and structure-activity relationships of new chiral 7-(1-, 3-, 4-, and 6-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)naphthyridine analogues of 7-[(1R,4R)-2,5- diazabicyclo[2.2.1]heptan-2-yl]-1-(1,1-
AID152307In vitro antibacterial activity against Proteus mirabilis A99001992Journal of medicinal chemistry, Jul-24, Volume: 35, Issue:15
Fluoronaphthyridines as antibacterial agents. 6. Synthesis and structure-activity relationships of new chiral 7-(1-, 3-, 4-, and 6-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)naphthyridine analogues of 7-[(1R,4R)-2,5- diazabicyclo[2.2.1]heptan-2-yl]-1-(1,1-
AID222234In vivo efficacy on systemic infections caused by Streptococcus pneumoniae A9585 in mice after peroral administration1992Journal of medicinal chemistry, Jul-24, Volume: 35, Issue:15
Fluoronaphthyridines as antibacterial agents. 6. Synthesis and structure-activity relationships of new chiral 7-(1-, 3-, 4-, and 6-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)naphthyridine analogues of 7-[(1R,4R)-2,5- diazabicyclo[2.2.1]heptan-2-yl]-1-(1,1-
AID164733Compound was tested in vitro for its antibacterial activity (minimum inhibitory concentration, MIC) against Pseudomonas aeruginosa A 98431991Journal of medicinal chemistry, Jan, Volume: 34, Issue:1
Fluoronaphthyridines and -quinolones as antibacterial agents. 3. Synthesis and structure-activity relationships of new 1-(1,1-dimethyl-2-fluoroethyl), 1-[1-methyl-1-(fluoromethyl)-2-fluoroethyl], and 1-[1,1-(difluoromethyl)-2-fluoroethyl] substituted deri
AID21159Percent urinary recovery in 24 hr after peroral administration to mice1992Journal of medicinal chemistry, Jul-24, Volume: 35, Issue:15
Fluoronaphthyridines as antibacterial agents. 6. Synthesis and structure-activity relationships of new chiral 7-(1-, 3-, 4-, and 6-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)naphthyridine analogues of 7-[(1R,4R)-2,5- diazabicyclo[2.2.1]heptan-2-yl]-1-(1,1-
AID201261In vitro antibacterial activity against Staphylococcus aureus A95371992Journal of medicinal chemistry, Jul-24, Volume: 35, Issue:15
Fluoronaphthyridines as antibacterial agents. 6. Synthesis and structure-activity relationships of new chiral 7-(1-, 3-, 4-, and 6-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)naphthyridine analogues of 7-[(1R,4R)-2,5- diazabicyclo[2.2.1]heptan-2-yl]-1-(1,1-
AID222231In vivo efficacy on systemic infections caused by Staphylococcus aureus A15090 in mice after intramuscular administration1992Journal of medicinal chemistry, Jul-24, Volume: 35, Issue:15
Fluoronaphthyridines as antibacterial agents. 6. Synthesis and structure-activity relationships of new chiral 7-(1-, 3-, 4-, and 6-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)naphthyridine analogues of 7-[(1R,4R)-2,5- diazabicyclo[2.2.1]heptan-2-yl]-1-(1,1-
AID202101In vitro antibacterial activity against Streptococcus pneumoniae A9585.1992Journal of medicinal chemistry, Jul-24, Volume: 35, Issue:15
Fluoronaphthyridines as antibacterial agents. 6. Synthesis and structure-activity relationships of new chiral 7-(1-, 3-, 4-, and 6-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)naphthyridine analogues of 7-[(1R,4R)-2,5- diazabicyclo[2.2.1]heptan-2-yl]-1-(1,1-
AID205394In vitro antibacterial activity (minimum inhibitory concentration) against Serratia marcescens A 20019.1991Journal of medicinal chemistry, Jan, Volume: 34, Issue:1
Fluoronaphthyridines and -quinolones as antibacterial agents. 3. Synthesis and structure-activity relationships of new 1-(1,1-dimethyl-2-fluoroethyl), 1-[1-methyl-1-(fluoromethyl)-2-fluoroethyl], and 1-[1,1-(difluoromethyl)-2-fluoroethyl] substituted deri
AID222229In vivo efficacy on systemic infections caused by Pseudomonas aeruginosa A9843 in mice after intramuscular administration1992Journal of medicinal chemistry, Jul-24, Volume: 35, Issue:15
Fluoronaphthyridines as antibacterial agents. 6. Synthesis and structure-activity relationships of new chiral 7-(1-, 3-, 4-, and 6-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)naphthyridine analogues of 7-[(1R,4R)-2,5- diazabicyclo[2.2.1]heptan-2-yl]-1-(1,1-
AID68180In vitro antibacterial activity against Enterobacter cloacae A 96561991Journal of medicinal chemistry, Jan, Volume: 34, Issue:1
Fluoronaphthyridines and -quinolones as antibacterial agents. 3. Synthesis and structure-activity relationships of new 1-(1,1-dimethyl-2-fluoroethyl), 1-[1-methyl-1-(fluoromethyl)-2-fluoroethyl], and 1-[1,1-(difluoromethyl)-2-fluoroethyl] substituted deri
AID13689Compound was evaluated in vivo in blood samples from the orbital sinus for its concentration after a peroral administration 40 mg/kg in mice1991Journal of medicinal chemistry, Jan, Volume: 34, Issue:1
Fluoronaphthyridines and -quinolones as antibacterial agents. 3. Synthesis and structure-activity relationships of new 1-(1,1-dimethyl-2-fluoroethyl), 1-[1-methyl-1-(fluoromethyl)-2-fluoroethyl], and 1-[1,1-(difluoromethyl)-2-fluoroethyl] substituted deri
AID10719Area under the concentration/ time determined against Bacillus subtilis ATCC 6633 after oral administration in dog(25 mg/kg)1990Journal of medicinal chemistry, May, Volume: 33, Issue:5
Fluoronaphthyridines and quinolones as antibacterial agents. 2. Synthesis and structure-activity relationships of new 1-tert-butyl 7-substituted derivatives.
AID11145Compound was evaluated in vivo in for its concentration using Area under the time-concentration curve after 40 mg/kg peroral administration to dogs.1991Journal of medicinal chemistry, Jan, Volume: 34, Issue:1
Fluoronaphthyridines and -quinolones as antibacterial agents. 3. Synthesis and structure-activity relationships of new 1-(1,1-dimethyl-2-fluoroethyl), 1-[1-methyl-1-(fluoromethyl)-2-fluoroethyl], and 1-[1,1-(difluoromethyl)-2-fluoroethyl] substituted deri
AID38483In vitro antibacterial activity against Bacteroides fragilis A-22,8621992Journal of medicinal chemistry, Jul-24, Volume: 35, Issue:15
Fluoronaphthyridines as antibacterial agents. 6. Synthesis and structure-activity relationships of new chiral 7-(1-, 3-, 4-, and 6-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)naphthyridine analogues of 7-[(1R,4R)-2,5- diazabicyclo[2.2.1]heptan-2-yl]-1-(1,1-
AID21165percent urinary recovery in 24 hr after intravenous administration to mice1992Journal of medicinal chemistry, Jul-24, Volume: 35, Issue:15
Fluoronaphthyridines as antibacterial agents. 6. Synthesis and structure-activity relationships of new chiral 7-(1-, 3-, 4-, and 6-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)naphthyridine analogues of 7-[(1R,4R)-2,5- diazabicyclo[2.2.1]heptan-2-yl]-1-(1,1-
AID24518Compound was evaluated in vivo in blood samples from the orbital sinus for its half life after 40 mg/kg of peroral administration in mice.1991Journal of medicinal chemistry, Jan, Volume: 34, Issue:1
Fluoronaphthyridines and -quinolones as antibacterial agents. 3. Synthesis and structure-activity relationships of new 1-(1,1-dimethyl-2-fluoroethyl), 1-[1-methyl-1-(fluoromethyl)-2-fluoroethyl], and 1-[1,1-(difluoromethyl)-2-fluoroethyl] substituted deri
AID24516Compound was evaluated in vivo for its half life after 40 mg/kg of peroral administration in dogs.1991Journal of medicinal chemistry, Jan, Volume: 34, Issue:1
Fluoronaphthyridines and -quinolones as antibacterial agents. 3. Synthesis and structure-activity relationships of new 1-(1,1-dimethyl-2-fluoroethyl), 1-[1-methyl-1-(fluoromethyl)-2-fluoroethyl], and 1-[1,1-(difluoromethyl)-2-fluoroethyl] substituted deri
AID222230In vivo efficacy on systemic infections caused by Pseudomonas aeruginosa A9843 in mice after peroral administration1992Journal of medicinal chemistry, Jul-24, Volume: 35, Issue:15
Fluoronaphthyridines as antibacterial agents. 6. Synthesis and structure-activity relationships of new chiral 7-(1-, 3-, 4-, and 6-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)naphthyridine analogues of 7-[(1R,4R)-2,5- diazabicyclo[2.2.1]heptan-2-yl]-1-(1,1-
AID103861In vitro antibacterial activity against Morganella morganii A151531992Journal of medicinal chemistry, Jul-24, Volume: 35, Issue:15
Fluoronaphthyridines as antibacterial agents. 6. Synthesis and structure-activity relationships of new chiral 7-(1-, 3-, 4-, and 6-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)naphthyridine analogues of 7-[(1R,4R)-2,5- diazabicyclo[2.2.1]heptan-2-yl]-1-(1,1-
AID95533In vitro antibacterial activity against Klebsiella pneumoniae A 96641991Journal of medicinal chemistry, Jan, Volume: 34, Issue:1
Fluoronaphthyridines and -quinolones as antibacterial agents. 3. Synthesis and structure-activity relationships of new 1-(1,1-dimethyl-2-fluoroethyl), 1-[1-methyl-1-(fluoromethyl)-2-fluoroethyl], and 1-[1,1-(difluoromethyl)-2-fluoroethyl] substituted deri
AID40339Compound was tested in vitro for its antibacterial activity (minimum inhibitory concentration) against Bacteroides fragilis A 22862.1991Journal of medicinal chemistry, Jan, Volume: 34, Issue:1
Fluoronaphthyridines and -quinolones as antibacterial agents. 3. Synthesis and structure-activity relationships of new 1-(1,1-dimethyl-2-fluoroethyl), 1-[1-methyl-1-(fluoromethyl)-2-fluoroethyl], and 1-[1,1-(difluoromethyl)-2-fluoroethyl] substituted deri
AID20933Compound was tested for its solubility at 20 degrees C and isoelectric pH.1991Journal of medicinal chemistry, Jan, Volume: 34, Issue:1
Fluoronaphthyridines and -quinolones as antibacterial agents. 3. Synthesis and structure-activity relationships of new 1-(1,1-dimethyl-2-fluoroethyl), 1-[1-methyl-1-(fluoromethyl)-2-fluoroethyl], and 1-[1,1-(difluoromethyl)-2-fluoroethyl] substituted deri
AID94069Efficacy on systematic infections against Klebsiella pneumoniae A 9664 after oral administration in mice1990Journal of medicinal chemistry, May, Volume: 33, Issue:5
Fluoronaphthyridines and quinolones as antibacterial agents. 2. Synthesis and structure-activity relationships of new 1-tert-butyl 7-substituted derivatives.
AID163608Compound was tested for the dose to protect 50% of mice from lethal infection against Pseudomonas aeruginosa A9843 after peroral administration to OF1-strain of female Swiss mice.1991Journal of medicinal chemistry, Jan, Volume: 34, Issue:1
Fluoronaphthyridines and -quinolones as antibacterial agents. 3. Synthesis and structure-activity relationships of new 1-(1,1-dimethyl-2-fluoroethyl), 1-[1-methyl-1-(fluoromethyl)-2-fluoroethyl], and 1-[1,1-(difluoromethyl)-2-fluoroethyl] substituted deri
AID134569Dose to protect 50% of mice from lethal infection after peroral administration.1990Journal of medicinal chemistry, May, Volume: 33, Issue:5
Fluoronaphthyridines and quinolones as antibacterial agents. 2. Synthesis and structure-activity relationships of new 1-tert-butyl 7-substituted derivatives.
AID96418In vitro minimum inhibitory concentration (MIC) against Klebsiella pneumoniae A 9664 at 37 degrees C for 18 h1990Journal of medicinal chemistry, May, Volume: 33, Issue:5
Fluoronaphthyridines and quinolones as antibacterial agents. 2. Synthesis and structure-activity relationships of new 1-tert-butyl 7-substituted derivatives.
AID11144Compound was evaluated in vivo in blood samples from the orbital sinus for its concentration using Area under the time-concentration curve after 40 mg/kg peroral administration to mice1991Journal of medicinal chemistry, Jan, Volume: 34, Issue:1
Fluoronaphthyridines and -quinolones as antibacterial agents. 3. Synthesis and structure-activity relationships of new 1-(1,1-dimethyl-2-fluoroethyl), 1-[1-methyl-1-(fluoromethyl)-2-fluoroethyl], and 1-[1,1-(difluoromethyl)-2-fluoroethyl] substituted deri
AID24186Partition coefficient (logD)1992Journal of medicinal chemistry, Jul-24, Volume: 35, Issue:15
Fluoronaphthyridines as antibacterial agents. 6. Synthesis and structure-activity relationships of new chiral 7-(1-, 3-, 4-, and 6-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)naphthyridine analogues of 7-[(1R,4R)-2,5- diazabicyclo[2.2.1]heptan-2-yl]-1-(1,1-
AID13900Maximum concentration determined against Bacillus subtilis ATCC 6633 after oral administration in dog(25 mg/kg)1990Journal of medicinal chemistry, May, Volume: 33, Issue:5
Fluoronaphthyridines and quinolones as antibacterial agents. 2. Synthesis and structure-activity relationships of new 1-tert-butyl 7-substituted derivatives.
AID21157Percent of dose administarted, for urinary recovery determined against Bacillus subtilis ATCC 6633 after oral administration in dog(25 mg/kg)1990Journal of medicinal chemistry, May, Volume: 33, Issue:5
Fluoronaphthyridines and quinolones as antibacterial agents. 2. Synthesis and structure-activity relationships of new 1-tert-butyl 7-substituted derivatives.
AID222226In vivo efficacy on systemic infections caused by Escherichia coli A15119 in mice after intramuscular administration1992Journal of medicinal chemistry, Jul-24, Volume: 35, Issue:15
Fluoronaphthyridines as antibacterial agents. 6. Synthesis and structure-activity relationships of new chiral 7-(1-, 3-, 4-, and 6-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)naphthyridine analogues of 7-[(1R,4R)-2,5- diazabicyclo[2.2.1]heptan-2-yl]-1-(1,1-
AID14289Peak concentration in blood after peroral administration to mice1992Journal of medicinal chemistry, Jul-24, Volume: 35, Issue:15
Fluoronaphthyridines as antibacterial agents. 6. Synthesis and structure-activity relationships of new chiral 7-(1-, 3-, 4-, and 6-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)naphthyridine analogues of 7-[(1R,4R)-2,5- diazabicyclo[2.2.1]heptan-2-yl]-1-(1,1-
AID94297In vitro antibacterial activity against Klebsiella pneumoniae A96641992Journal of medicinal chemistry, Jul-24, Volume: 35, Issue:15
Fluoronaphthyridines as antibacterial agents. 6. Synthesis and structure-activity relationships of new chiral 7-(1-, 3-, 4-, and 6-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)naphthyridine analogues of 7-[(1R,4R)-2,5- diazabicyclo[2.2.1]heptan-2-yl]-1-(1,1-
AID197849Efficacy on systematic infections against Staphylococcus aureus A 9537 after oral administration in mice1990Journal of medicinal chemistry, May, Volume: 33, Issue:5
Fluoronaphthyridines and quinolones as antibacterial agents. 2. Synthesis and structure-activity relationships of new 1-tert-butyl 7-substituted derivatives.
AID205830In vitro antibacterial activity against Staphylococcus aureus A 242271991Journal of medicinal chemistry, Jan, Volume: 34, Issue:1
Fluoronaphthyridines and -quinolones as antibacterial agents. 3. Synthesis and structure-activity relationships of new 1-(1,1-dimethyl-2-fluoroethyl), 1-[1-methyl-1-(fluoromethyl)-2-fluoroethyl], and 1-[1,1-(difluoromethyl)-2-fluoroethyl] substituted deri
AID67228In vitro antibacterial activity against Enterococcus faecalis A 98091991Journal of medicinal chemistry, Jan, Volume: 34, Issue:1
Fluoronaphthyridines and -quinolones as antibacterial agents. 3. Synthesis and structure-activity relationships of new 1-(1,1-dimethyl-2-fluoroethyl), 1-[1-methyl-1-(fluoromethyl)-2-fluoroethyl], and 1-[1,1-(difluoromethyl)-2-fluoroethyl] substituted deri
AID14288Peak concentration in blood after intravenous administration to mice1992Journal of medicinal chemistry, Jul-24, Volume: 35, Issue:15
Fluoronaphthyridines as antibacterial agents. 6. Synthesis and structure-activity relationships of new chiral 7-(1-, 3-, 4-, and 6-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)naphthyridine analogues of 7-[(1R,4R)-2,5- diazabicyclo[2.2.1]heptan-2-yl]-1-(1,1-
AID206690Compound was tested for the dose to protect 50% of mice from lethal infection against Streptococcus pneumoniae after peroral administration to OF1-strain of female Swiss mice.1991Journal of medicinal chemistry, Jan, Volume: 34, Issue:1
Fluoronaphthyridines and -quinolones as antibacterial agents. 3. Synthesis and structure-activity relationships of new 1-(1,1-dimethyl-2-fluoroethyl), 1-[1-methyl-1-(fluoromethyl)-2-fluoroethyl], and 1-[1,1-(difluoromethyl)-2-fluoroethyl] substituted deri
AID222232In vivo efficacy on systemic infections caused by Staphylococcus aureus A15090 in mice after peroral administration1992Journal of medicinal chemistry, Jul-24, Volume: 35, Issue:15
Fluoronaphthyridines as antibacterial agents. 6. Synthesis and structure-activity relationships of new chiral 7-(1-, 3-, 4-, and 6-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)naphthyridine analogues of 7-[(1R,4R)-2,5- diazabicyclo[2.2.1]heptan-2-yl]-1-(1,1-
AID11143Compound was evaluated in vivo in blood samples from the orbital sinus for its concentration using Area under the time-concentration curve after 40 mg/kg intramuscular administration to mice1991Journal of medicinal chemistry, Jan, Volume: 34, Issue:1
Fluoronaphthyridines and -quinolones as antibacterial agents. 3. Synthesis and structure-activity relationships of new 1-(1,1-dimethyl-2-fluoroethyl), 1-[1-methyl-1-(fluoromethyl)-2-fluoroethyl], and 1-[1,1-(difluoromethyl)-2-fluoroethyl] substituted deri
AID13687Compound was evaluated in vivo for its concentration after a peroral administration 40 mg/kg in dogs.1991Journal of medicinal chemistry, Jan, Volume: 34, Issue:1
Fluoronaphthyridines and -quinolones as antibacterial agents. 3. Synthesis and structure-activity relationships of new 1-(1,1-dimethyl-2-fluoroethyl), 1-[1-methyl-1-(fluoromethyl)-2-fluoroethyl], and 1-[1,1-(difluoromethyl)-2-fluoroethyl] substituted deri
AID222233In vivo efficacy on systemic infections caused by Streptococcus pneumoniae A9585 in mice after intramuscular administration1992Journal of medicinal chemistry, Jul-24, Volume: 35, Issue:15
Fluoronaphthyridines as antibacterial agents. 6. Synthesis and structure-activity relationships of new chiral 7-(1-, 3-, 4-, and 6-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)naphthyridine analogues of 7-[(1R,4R)-2,5- diazabicyclo[2.2.1]heptan-2-yl]-1-(1,1-
AID64256In vitro minimum inhibitory concentration (MIC) against Enterococcus faecalis A 9808 at 37 degrees C for 18 h.1990Journal of medicinal chemistry, May, Volume: 33, Issue:5
Fluoronaphthyridines and quinolones as antibacterial agents. 2. Synthesis and structure-activity relationships of new 1-tert-butyl 7-substituted derivatives.
AID162744In vitro antibacterial activity (minimum inhibitory concentration, MIC) against Proteus mirabilis A 99001991Journal of medicinal chemistry, Jan, Volume: 34, Issue:1
Fluoronaphthyridines and -quinolones as antibacterial agents. 3. Synthesis and structure-activity relationships of new 1-(1,1-dimethyl-2-fluoroethyl), 1-[1-methyl-1-(fluoromethyl)-2-fluoroethyl], and 1-[1,1-(difluoromethyl)-2-fluoroethyl] substituted deri
AID125278In vitro minimum inhibitory concentration (MIC) against Morganella morganii A 15153 at 37 degrees C for 18 h.1990Journal of medicinal chemistry, May, Volume: 33, Issue:5
Fluoronaphthyridines and quinolones as antibacterial agents. 2. Synthesis and structure-activity relationships of new 1-tert-butyl 7-substituted derivatives.
AID201746In vitro antibacterial activity against Serratia marcescens A200191992Journal of medicinal chemistry, Jul-24, Volume: 35, Issue:15
Fluoronaphthyridines as antibacterial agents. 6. Synthesis and structure-activity relationships of new chiral 7-(1-, 3-, 4-, and 6-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)naphthyridine analogues of 7-[(1R,4R)-2,5- diazabicyclo[2.2.1]heptan-2-yl]-1-(1,1-
AID150902In vitro minimum inhibitory concentration (MIC) against Pseudomonas aeruginosa A 9843 at 37 degree C for 18 h1990Journal of medicinal chemistry, May, Volume: 33, Issue:5
Fluoronaphthyridines and quinolones as antibacterial agents. 2. Synthesis and structure-activity relationships of new 1-tert-butyl 7-substituted derivatives.
AID150907Efficacy on systematic infections against Pseudomonas aeruginosa A 9843 after oral administration in mice1990Journal of medicinal chemistry, May, Volume: 33, Issue:5
Fluoronaphthyridines and quinolones as antibacterial agents. 2. Synthesis and structure-activity relationships of new 1-tert-butyl 7-substituted derivatives.
AID13550Area under curve measured as conc vs time after peroral administration to mice.1992Journal of medicinal chemistry, Jul-24, Volume: 35, Issue:15
Fluoronaphthyridines as antibacterial agents. 6. Synthesis and structure-activity relationships of new chiral 7-(1-, 3-, 4-, and 6-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)naphthyridine analogues of 7-[(1R,4R)-2,5- diazabicyclo[2.2.1]heptan-2-yl]-1-(1,1-
AID134550Compound was tested for its acute toxicity after intravenous (iv) administration to OF1-strain of female Swiss mice.1991Journal of medicinal chemistry, Jan, Volume: 34, Issue:1
Fluoronaphthyridines and -quinolones as antibacterial agents. 3. Synthesis and structure-activity relationships of new 1-(1,1-dimethyl-2-fluoroethyl), 1-[1-methyl-1-(fluoromethyl)-2-fluoroethyl], and 1-[1,1-(difluoromethyl)-2-fluoroethyl] substituted deri
AID21967Tested for aqueous solubility1990Journal of medicinal chemistry, May, Volume: 33, Issue:5
Fluoronaphthyridines and quinolones as antibacterial agents. 2. Synthesis and structure-activity relationships of new 1-tert-butyl 7-substituted derivatives.
AID151545In vitro antibacterial activity against Pseudomonas aeruginosa A98431992Journal of medicinal chemistry, Jul-24, Volume: 35, Issue:15
Fluoronaphthyridines as antibacterial agents. 6. Synthesis and structure-activity relationships of new chiral 7-(1-, 3-, 4-, and 6-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)naphthyridine analogues of 7-[(1R,4R)-2,5- diazabicyclo[2.2.1]heptan-2-yl]-1-(1,1-
AID200257In vitro minimum inhibitory concentration (MIC) against Staphylococcus aureus Smith A 9537 at 37 degrees C for 18 hr1990Journal of medicinal chemistry, May, Volume: 33, Issue:5
Fluoronaphthyridines and quinolones as antibacterial agents. 2. Synthesis and structure-activity relationships of new 1-tert-butyl 7-substituted derivatives.
AID24517Compound was evaluated in vivo in blood samples from the orbital sinus for its half life after 40 mg/kg of intramuscular administration in mice.1991Journal of medicinal chemistry, Jan, Volume: 34, Issue:1
Fluoronaphthyridines and -quinolones as antibacterial agents. 3. Synthesis and structure-activity relationships of new 1-(1,1-dimethyl-2-fluoroethyl), 1-[1-methyl-1-(fluoromethyl)-2-fluoroethyl], and 1-[1,1-(difluoromethyl)-2-fluoroethyl] substituted deri
AID198156In vitro minimum inhibitory concentration (MIC) against Serratia marcescens A 20019 at 37 degrees C for 18 hr1990Journal of medicinal chemistry, May, Volume: 33, Issue:5
Fluoronaphthyridines and quinolones as antibacterial agents. 2. Synthesis and structure-activity relationships of new 1-tert-butyl 7-substituted derivatives.
AID64396In vitro antibacterial activity against Enterobacter cloacae A96561992Journal of medicinal chemistry, Jul-24, Volume: 35, Issue:15
Fluoronaphthyridines as antibacterial agents. 6. Synthesis and structure-activity relationships of new chiral 7-(1-, 3-, 4-, and 6-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)naphthyridine analogues of 7-[(1R,4R)-2,5- diazabicyclo[2.2.1]heptan-2-yl]-1-(1,1-
AID85970In vitro antibacterial activity against Haemophilus influenzae A 215151991Journal of medicinal chemistry, Jan, Volume: 34, Issue:1
Fluoronaphthyridines and -quinolones as antibacterial agents. 3. Synthesis and structure-activity relationships of new 1-(1,1-dimethyl-2-fluoroethyl), 1-[1-methyl-1-(fluoromethyl)-2-fluoroethyl], and 1-[1,1-(difluoromethyl)-2-fluoroethyl] substituted deri
AID13691Compound was evaluated in vivo in blood samples from the orbital sinus for its concentration after an intramuscular administration of 40 mg/kg in mice1991Journal of medicinal chemistry, Jan, Volume: 34, Issue:1
Fluoronaphthyridines and -quinolones as antibacterial agents. 3. Synthesis and structure-activity relationships of new 1-(1,1-dimethyl-2-fluoroethyl), 1-[1-methyl-1-(fluoromethyl)-2-fluoroethyl], and 1-[1,1-(difluoromethyl)-2-fluoroethyl] substituted deri
AID70281Compound was tested for the dose to protect 50% of mice from lethal infection against Escherichia coli A 15119 after peroral administration to OF1-strain of female Swiss mice.1991Journal of medicinal chemistry, Jan, Volume: 34, Issue:1
Fluoronaphthyridines and -quinolones as antibacterial agents. 3. Synthesis and structure-activity relationships of new 1-(1,1-dimethyl-2-fluoroethyl), 1-[1-methyl-1-(fluoromethyl)-2-fluoroethyl], and 1-[1,1-(difluoromethyl)-2-fluoroethyl] substituted deri
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (16.67)18.7374
1990's5 (83.33)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]