Compounds > elaiophylin
Page last updated: 2024-11-11

elaiophylin

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Cross-References

ID SourceID
PubMed CID6444206
CHEMBL ID3740707
CHEBI ID77879
SCHEMBL ID1231934
MeSH IDM0103330

Synonyms (35)

Synonym
(3e,5e,7s,8s,11e,13e,15s,16s)-8,16-bis[(1s,2r,3s)-3-[(2r,4r,5r,6r)-4-[(2r,4s,5s,6s)-4,5-dihydroxy-6-methyl-tetrahydropyran-2-yl]oxy-5-ethyl-2-hydroxy-6-methyl-tetrahydropyran-2-yl]-2-hydroxy-1-methyl-butyl]-7,15-dimethyl-1,9-dioxacyclohexadeca-3,5,11,13-t
elaiophylin ,
elaiofilin
37318-06-2
azalomycin b
5001b
antibiotic 56-62
antibiotic 5001b
(3e,5e,7s,8s,11e,13e,15s,16s)-8,16-bis[(2s,3r,4s)-4-[(2r,4r,5r,6r)-4-[(2r,4s,5s,6s)-4,5-dihydroxy-6-methyloxan-2-yl]oxy-5-ethyl-2-hydroxy-6-methyloxan-2-yl]-3-hydroxypentan-2-yl]-7,15-dimethyl-1,9-dioxacyclohexadeca-3,5,11,13-tetraene-2,10-dione
AZALOMYCIN-B ,
salbomycin
gopalamicin
unii-1caf8865tm
1caf8865tm ,
efomycine e
efomycin e
(+)-elaiophylin
antibiotic a-164ab
CHEBI:77879
(3e,5e,7s,8s,11e,13e,15s,16s)-8,16-bis{(2s,3r,4s)-4-[(2r,4r,5r,6r)-4-{[(2r,4s,5s,6s)-4,5-dihydroxy-6-methyltetrahydro-2h-pyran-2-yl]oxy}-5-ethyl-2-hydroxy-6-methyltetrahydro-2h-pyran-2-yl]-3-hydroxypentan-2-yl}-7,15-dimethyl-1,9-dioxacyclohexadeca-3,5,11,
SCHEMBL1231934
c54h88o18
HB0273
azalomycin-b; gopalamicin; salbomycin
CHEMBL3740707
(3e,5e,7s,8s,11e,13e,15s,16s)-8,16-bis((2s,3r,4s)-4-((2r,4r,5r,6r)-4-(((2r,4s,5s,6s)-4,5-dihydroxy-6-methyltetrahydro-2h-pyran-2-yl)oxy)-5-ethyl-2-hydroxy-6-methyltetrahydro-2h-pyran-2-yl)-3-hydroxypentan-2-yl)-7,15-dimethyl-1,9-dioxacyclohexadeca-3,5,11,
AKOS032945123
Q27147492
EX-A3078
CS-0003802
HY-15184
DTXSID001318254
ELO ,
AT33746
AC-35864

Research Excerpts

Overview

Elaiophylin is a natural compound and a potent inhibitor of late stage autophagy with outstanding antitumor activity in human ovarian cancer cells. It is an unusual C2 -symmetric antibiotic macrodiolide produced on a bacterial modular polyketide synthase assembly line.

ExcerptReferenceRelevance
"Elaiophylin is a natural compound and a novel and potent inhibitor of late stage autophagy with outstanding antitumor activity in human ovarian cancer cells. "( The novel autophagy inhibitor elaiophylin exerts antitumor activity against multiple myeloma with mutant TP53 in part through endoplasmic reticulum stress-induced apoptosis.
Chen, X; Fang, Y; Tan, J; Wang, G; Yang, Y; Zhao, L; Zhou, J; Zhou, P, 2017)		2.19
"Elaiophylin is an unusual C2 -symmetric antibiotic macrodiolide produced on a bacterial modular polyketide synthase assembly line. "( Macrodiolide formation by the thioesterase of a modular polyketide synthase.
Dias, LC; Leadlay, PF; Murphy, AC; Prediger, P; Zhou, Y, 2015)		1.86

Actions

ExcerptReferenceRelevance
"Elaiophylin promotes autophagosome accumulation but blocks autophagic flux by attenuating lysosomal cathepsin activity, resulting in the accumulation of SQSTM1/p62 in various cell lines."( Elaiophylin, a novel autophagy inhibitor, exerts antitumor activity as a single agent in ovarian cancer cells.
Fang, Y; Gao, Q; Lai, H; Lu, X; Ma, D; Meng, L; Qin, Y; Wang, D; Wang, T; Wu, P; Yang, Y; Zhang, H; Zhao, X; Zheng, Z; Zhou, J, 2015)		2.58
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (3)

RoleDescription
bacterial metaboliteAny prokaryotic metabolite produced during a metabolic reaction in bacteria.
antifungal agentAn antimicrobial agent that destroys fungi by suppressing their ability to grow or reproduce.
autophagy inhibitorAny compound that inhibits the process of autophagy (the self-digestion of one or more components of a cell through the action of enzymes originating within the same cell).
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (3)

ClassDescription
lactolCyclic hemiacetals formed by intramolecular addition of a hydroxy group to an aldehydic or ketonic carbonyl group. They are thus 1-oxacycloalkan-2-ols or unsaturated analogues.
monosaccharide derivativeA carbohydrate derivative that is formally obtained from a monosaccharide.
macrodiolideA macropolylide which contains two ester linkages in one macrocyclic ring.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (25)

Assay IDTitleYearJournalArticle
AID1853751Cytotoxicity against human MCF7 cells assessed as cell growth inhibition2022European journal of medicinal chemistry, Feb-15, Volume: 230Natural products from mangrove sediments-derived microbes: Structural diversity, bioactivities, biosynthesis, and total synthesis.
AID1544743Cytotoxicity against human DU145 cells assessed as reduction in cell viability incubated for 24 hrs by FMCA method2019Bioorganic & medicinal chemistry, 07-01, Volume: 27, Issue:13
Identification of BMI1 promoter inhibitors from Streptomyces sp. IFM-11958.
AID1544749Up-regulation of p16Ink4a mRNA expression in human DU145 cells incubated for 24 hrs by Quantitative RT-PCR analysis2019Bioorganic & medicinal chemistry, 07-01, Volume: 27, Issue:13
Identification of BMI1 promoter inhibitors from Streptomyces sp. IFM-11958.
AID1544742Inhibition of BMI1 promoter in HEK293T cells incubated for 24 hrs by luciferase reporter gene assay2019Bioorganic & medicinal chemistry, 07-01, Volume: 27, Issue:13
Identification of BMI1 promoter inhibitors from Streptomyces sp. IFM-11958.
AID1264895Antimicrobial activity against Escherichia coli ATCC 11775 for 17 to 48 hrs by MTT assay2015Journal of natural products, Nov-25, Volume: 78, Issue:11
Identification of Elaiophylin Skeletal Variants from the Indonesian Streptomyces sp. ICBB 9297.
AID1544745Cytotoxicity against HEK293 cells assessed as reduction in cell viability incubated for 24 hrs by FMCA method2019Bioorganic & medicinal chemistry, 07-01, Volume: 27, Issue:13
Identification of BMI1 promoter inhibitors from Streptomyces sp. IFM-11958.
AID1853776Cytotoxicity against human HeLa cells assessed as cell growth inhibition2022European journal of medicinal chemistry, Feb-15, Volume: 230Natural products from mangrove sediments-derived microbes: Structural diversity, bioactivities, biosynthesis, and total synthesis.
AID1264893Antimicrobial activity against Bacillus subtilis ATCC 6051 for 17 to 48 hrs by MTT assay2015Journal of natural products, Nov-25, Volume: 78, Issue:11
Identification of Elaiophylin Skeletal Variants from the Indonesian Streptomyces sp. ICBB 9297.
AID1768868Inhibition of NorA in Staphylococcus aureus SA-1199B assessed as potentiation of ethidium bromide-mediated antibacterial activity by measuring ethidium bromide MIC incubated for 24 hrs by resazurin assay2021Bioorganic & medicinal chemistry letters, 10-15, Volume: 50Evaluation of Elaiophylin extracted from Streptomyces hygroscopicus as a potential inhibitor of the NorA efflux protein in Staphylococcus aureus: An in vitro and in silico approach.
AID1768867Inhibition of NorA in Staphylococcus aureus SA-1199 assessed as potentiation of ethidium bromide-mediated antibacterial activity by measuring ethidium bromide MIC incubated for 24 hrs by resazurin assay2021Bioorganic & medicinal chemistry letters, 10-15, Volume: 50Evaluation of Elaiophylin extracted from Streptomyces hygroscopicus as a potential inhibitor of the NorA efflux protein in Staphylococcus aureus: An in vitro and in silico approach.
AID1544748Down-regulation of BMI1 mRNA expression in human DU145 cells incubated for 24 hrs by Quantitative RT-PCR analysis2019Bioorganic & medicinal chemistry, 07-01, Volume: 27, Issue:13
Identification of BMI1 promoter inhibitors from Streptomyces sp. IFM-11958.
AID1544741Inhibition of sphere formation in human HuH7 cells incubated for 72 hrs by sphere forming assay2019Bioorganic & medicinal chemistry, 07-01, Volume: 27, Issue:13
Identification of BMI1 promoter inhibitors from Streptomyces sp. IFM-11958.
AID1544747Down-regulation of c-Myc protein expression in human DU145 cells incubated for 24 hrs by Western blot analysis2019Bioorganic & medicinal chemistry, 07-01, Volume: 27, Issue:13
Identification of BMI1 promoter inhibitors from Streptomyces sp. IFM-11958.
AID1768869Decrease in NorA gene expression in Staphylococcus aureus SA-1199B by RT-qPCR2021Bioorganic & medicinal chemistry letters, 10-15, Volume: 50Evaluation of Elaiophylin extracted from Streptomyces hygroscopicus as a potential inhibitor of the NorA efflux protein in Staphylococcus aureus: An in vitro and in silico approach.
AID1768863Antibacterial activity against wild-type Staphylococcus aureus SA-1199 incubated for 24 hrs by broth microdilution method2021Bioorganic & medicinal chemistry letters, 10-15, Volume: 50Evaluation of Elaiophylin extracted from Streptomyces hygroscopicus as a potential inhibitor of the NorA efflux protein in Staphylococcus aureus: An in vitro and in silico approach.
AID1264892Antimicrobial activity against Mycobacterium smegmatis ATCC 14468 for 17 to 48 hrs by MTT assay2015Journal of natural products, Nov-25, Volume: 78, Issue:11
Identification of Elaiophylin Skeletal Variants from the Indonesian Streptomyces sp. ICBB 9297.
AID1544746Down-regulation of BMI1 protein expression in human DU145 cells incubated for 24 hrs by Western blot analysis2019Bioorganic & medicinal chemistry, 07-01, Volume: 27, Issue:13
Identification of BMI1 promoter inhibitors from Streptomyces sp. IFM-11958.
AID1264894Antimicrobial activity against Pseudomonas aeruginosa ATCC 9721 for 17 to 48 hrs by MTT assay2015Journal of natural products, Nov-25, Volume: 78, Issue:11
Identification of Elaiophylin Skeletal Variants from the Indonesian Streptomyces sp. ICBB 9297.
AID1683143Toxicity in Artemia salina assessed as mortality at 10 ug/ml after 24 hrs by Meyer method
AID1768865Inhibition of NorA in Staphylococcus aureus SA-1199 assessed as potentiation of norfloxacin-mediated antibacterial activity by measuring norfloxacin MIC incubated for 24 hrs by resazurin assay2021Bioorganic & medicinal chemistry letters, 10-15, Volume: 50Evaluation of Elaiophylin extracted from Streptomyces hygroscopicus as a potential inhibitor of the NorA efflux protein in Staphylococcus aureus: An in vitro and in silico approach.
AID1768864Antibacterial activity against Staphylococcus aureus SA-1199B overexpressing NorA incubated for 24 hrs by broth microdilution method2021Bioorganic & medicinal chemistry letters, 10-15, Volume: 50Evaluation of Elaiophylin extracted from Streptomyces hygroscopicus as a potential inhibitor of the NorA efflux protein in Staphylococcus aureus: An in vitro and in silico approach.
AID1264891Antimicrobial activity against Staphylococcus aureus ATCC 12600 for 17 to 48 hrs by MTT assay2015Journal of natural products, Nov-25, Volume: 78, Issue:11
Identification of Elaiophylin Skeletal Variants from the Indonesian Streptomyces sp. ICBB 9297.
AID1768866Inhibition of NorA in Staphylococcus aureus SA-1199B assessed as potentiation of norfloxacin-mediated antibacterial activity by measuring norfloxacin MIC incubated for 24 hrs by resazurin assay2021Bioorganic & medicinal chemistry letters, 10-15, Volume: 50Evaluation of Elaiophylin extracted from Streptomyces hygroscopicus as a potential inhibitor of the NorA efflux protein in Staphylococcus aureus: An in vitro and in silico approach.
AID1768870Decrease in NorA gene expression in Staphylococcus aureus SA-1199B in combination with norfloxacin by RT-qPCR2021Bioorganic & medicinal chemistry letters, 10-15, Volume: 50Evaluation of Elaiophylin extracted from Streptomyces hygroscopicus as a potential inhibitor of the NorA efflux protein in Staphylococcus aureus: An in vitro and in silico approach.
AID1544744Cytotoxicity against human HuH7 cells assessed as reduction in cell viability incubated for 24 hrs by FMCA method2019Bioorganic & medicinal chemistry, 07-01, Volume: 27, Issue:13
Identification of BMI1 promoter inhibitors from Streptomyces sp. IFM-11958.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (39)

TimeframeStudies, This Drug (%)All Drugs %
pre-19905 (12.82)18.7374
1990's4 (10.26)18.2507
2000's5 (12.82)29.6817
2010's16 (41.03)24.3611
2020's9 (23.08)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 24.75

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index24.75 (24.57)
Research Supply Index3.71 (2.92)
Research Growth Index5.13 (4.65)
Search Engine Demand Index26.67 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (24.75)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews2 (5.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other38 (95.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
propionic acid
propionic acid : A short-chain saturated fatty acid comprising ethane attached to the carbon of a carboxy group.		1.9810saturated fatty acid;
short-chain fatty acid		antifungal drug
carbonyl cyanide m-chlorophenyl hydrazone
Carbonyl Cyanide m-Chlorophenyl Hydrazone: A proton ionophore. It is commonly used as an uncoupling agent and inhibitor of photosynthesis because of its effects on mitochondrial and chloroplast membranes.. CCCP : A member of the class of monochlorobenzenes that is benzene substituted by 2-(1,3-dinitrilopropan-2-ylidene)hydrazinyl and chloro groups at positions 1 and 3, respectively. It is a mitochondrial depolarizing agent that induces reactive oxygen species mediated cell death.		2.3110hydrazone;
monochlorobenzenes;
nitrile		antibacterial agent;
geroprotector;
ionophore
celecoxib
[no description available]		3.5110organofluorine compound;
pyrazoles;
sulfonamide;
toluenes		cyclooxygenase 2 inhibitor;
geroprotector;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug
norfloxacin
Norfloxacin: A synthetic fluoroquinolone (FLUOROQUINOLONES) with broad-spectrum antibacterial activity against most gram-negative and gram-positive bacteria. Norfloxacin inhibits bacterial DNA GYRASE.. norfloxacin : A quinolinemonocarboxylic acid with broad-spectrum antibacterial activity against most gram-negative and gram-positive bacteria. Norfloxacin is bactericidal and its mode of action depends on blocking of bacterial DNA replication by binding itself to an enzyme called DNA gyrase.		2.3110fluoroquinolone antibiotic;
N-arylpiperazine;
quinolinemonocarboxylic acid;
quinolone antibiotic;
quinolone		antibacterial drug;
DNA synthesis inhibitor;
environmental contaminant;
xenobiotic
thymidine
[no description available]		2.4110pyrimidine 2'-deoxyribonucleosideEscherichia coli metabolite;
human metabolite;
metabolite;
mouse metabolite
uridine diphosphate
Uridine Diphosphate: A uracil nucleotide containing a pyrophosphate group esterified to C5 of the sugar moiety.		2.4110pyrimidine ribonucleoside 5'-diphosphate;
uridine 5'-phosphate		Escherichia coli metabolite;
mouse metabolite
ampicillin
Ampicillin: Semi-synthetic derivative of penicillin that functions as an orally active broad-spectrum antibiotic.. ampicillin : A penicillin in which the substituent at position 6 of the penam ring is a 2-amino-2-phenylacetamido group.		2.1110beta-lactam antibiotic;
penicillin allergen;
penicillin		antibacterial drug
vancomycin
Vancomycin: Antibacterial obtained from Streptomyces orientalis. It is a glycopeptide related to RISTOCETIN that inhibits bacterial cell wall assembly and is toxic to kidneys and the inner ear.. vancomycin : A complex glycopeptide from Streptomyces orientalis. It inhibits a specific step in the synthesis of the peptidoglycan layer in the Gram-positive bacteria Staphylococcus aureus and Clostridium difficile.		2.0810glycopeptideantibacterial drug;
antimicrobial agent;
bacterial metabolite
benomyl
[no description available]		2.1310aromatic amide;
benzimidazole fungicide;
benzimidazoles;
benzimidazolylcarbamate fungicide;
carbamate ester		acaricide;
anthelminthic drug;
antifungal agrochemical;
microtubule-destabilising agent;
tubulin modulator
nigericin
Nigericin: A polyether antibiotic which affects ion transport and ATPase activity in mitochondria. It is produced by Streptomyces hygroscopicus. (From Merck Index, 11th ed). nigericin : A polyether antibiotic which affects ion transport and ATPase activity in mitochondria. It is produced by Streptomyces hygroscopicus.		2.6830polycyclic etherantibacterial agent;
antimicrobial agent;
bacterial metabolite;
potassium ionophore
caloreen
caloreen: glucose polymer with average length of five glucose units for dietary energy supplement. dextrin : Glucans produced by the hydrolysis of starch or glycogen. They are mixtures of polymers of D-glucose units linked by alpha(1->4) or alpha(1->6) glycosidic bonds.		2.0210
deferrioxamine e
deferrioxamine E: may act as siderophore in Streptomyces. desferrioxamine E : A cyclic hydroxamic acid siderophore that is produced by several bacterial species and exhibits antitumour activity.		2.2110cyclic desferrioxamine;
cyclic hydroxamic acid;
macrocycle		antineoplastic agent;
bacterial metabolite;
marine metabolite;
siderophore
taurochenodeoxycholic acid
Taurochenodeoxycholic Acid: A bile salt formed in the liver by conjugation of chenodeoxycholate with taurine, usually as the sodium salt. It acts as detergent to solubilize fats in the small intestine and is itself absorbed. It is used as a cholagogue and choleretic.. taurochenodeoxycholate : An organosulfonate oxoanion that is the conjugate base of taurochenodeoxycholic acid arising from deprotonation of the sulfonate OH group; major species at pH 7.3.. taurochenodeoxycholic acid : A bile acid taurine conjugate of chenodeoxycholic acid.		2.1510bile acid taurine conjugatehuman metabolite;
mouse metabolite
pyrophosphate
Diphosphates: Inorganic salts of phosphoric acid that contain two phosphate groups.		2.4110diphosphate ion
apramycin
apramycin : An aminoglycoside that is 2-deoxystreptamine that is substituted on the oxygen at position 4 by an (8R)-2-amino-8-O-(4-amino-4-deoxy-alpha-D-glucopyranosyl)-2,3,7-trideoxy-7-(methylamino)-D-glycero-alpha-D-allo-octodialdo-1,5:8,4-dipyranos-1-yl) group.		2.11102-deoxystreptamine derivative;
aminoglycoside;
organic heterobicyclic compound		antibacterial drug;
antimicrobial agent
sirolimus
Sirolimus: A macrolide compound obtained from Streptomyces hygroscopicus that acts by selectively blocking the transcriptional activation of cytokines thereby inhibiting cytokine production. It is bioactive only when bound to IMMUNOPHILINS. Sirolimus is a potent immunosuppressant and possesses both antifungal and antineoplastic properties.. sirolimus : A macrolide lactam isolated from Streptomyces hygroscopicus consisting of a 29-membered ring containing 4 trans double bonds, three of which are conjugated. It is an antibiotic, immunosupressive and antineoplastic agent.		2.4720antibiotic antifungal drug;
cyclic acetal;
cyclic ketone;
ether;
macrolide lactam;
organic heterotricyclic compound;
secondary alcohol		antibacterial drug;
anticoronaviral agent;
antineoplastic agent;
bacterial metabolite;
geroprotector;
immunosuppressive agent;
mTOR inhibitor
geldanamycin
[no description available]		2.9740
azalomycin-f
azalomycin-F: a macrocyclic lactone antibiotic		3.5110
clasto-lactacystin beta-lactone
clasto-lactacystin beta-lactone: active metabolite of lactacystin; inhibits 20 S proteasome; structure in first source		3.5110
reblastatin
reblastatin: structure in first source		7.1510
ursodoxicoltaurine
tauroursodeoxycholate : An organosulfonate oxoanion that is the conjugate base of tauroursodeoxycholic acid arising from deprotonation of the sulfonate OH group; major species at pH 7.3.. tauroursodeoxycholic acid : A bile acid taurine conjugate derived from ursoodeoxycholic acid.		2.1510bile acid taurine conjugateanti-inflammatory agent;
apoptosis inhibitor;
bone density conservation agent;
cardioprotective agent;
human metabolite;
neuroprotective agent
marizomib
marizomib: a proteasome inhibitor from a marine bacterium Salinospora; structure in first source		3.5110beta-lactone;
gamma-lactam;
organic heterobicyclic compound;
organochlorine compound;
salinosporamide		antineoplastic agent;
proteasome inhibitor
niphimycin
niphimycin: RN's in Chemline for cpds of unknown MF's; niphimycin A1: 56645-56-8; niphimycin A2: 56644-96-3; niphimycin B1: 56645-55-7; niphimycin B2: 56645-54-6		6.9710
methylmalonyl-coenzyme a
[no description available]		2.1110
aspulvinone E
4-hydroxy-5-(4-hydroxybenzylidene)-3-(4-hydroxyphenyl)furan-2(5H)-one : A member of the class of butenolides that is furan-2(5H)-one substituted by 4-hydroxyphenyl, hydroxy and 4-hydroxybenzylidene groups at positions 3, 4 and 5, respectively.. aspulvinone E : A 4-hydroxy-5-(4-hydroxybenzylidene)-3-(4-hydroxyphenyl)furan-2(5H)-one in which the double bond adopts a Z-configuration. It is a marine metabolite isolated from the fungus Aspergillus terreus and exhibits antiviral activity.		3.51104-hydroxy-5-(4-hydroxybenzylidene)-3-(4-hydroxyphenyl)furan-2(5H)-one;
aspulvinone		antiviral agent;
Aspergillus metabolite;
EC 3.2.1.20 (alpha-glucosidase) inhibitor;
marine metabolite
hunanamycin a
hunanamycin A: antibiotic from a marine-derived Bacillus hunanensis; structure in first source		3.5110
cobamamide
cobamamide : A member of the class of cobalamins that is vitamin B12 in which the cyano group is replaced by a 5'-deoxyadenos-5'-yl moiety. It is one of the two metabolically active form of vitamin B12.		2.0210
ConditionIndicatedRelationship StrengthStudiesTrials
Body Weight
The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.		07.3110
Cancer of Ovary
[description not available]		02.5920
Ovarian Neoplasms
Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS.		02.5920
Cancer of Pancreas
[description not available]		03.5240
Pancreatic Neoplasms
Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).		03.5240
Allergic Reaction
[description not available]		03.1210
Palmoplantaris Pustulosis
[description not available]		03.1210
Hypersensitivity
Altered reactivity to an antigen, which can result in pathologic reactions upon subsequent exposure to that particular antigen.		03.1210
Psoriasis
A common genetically determined, chronic, inflammatory skin disease characterized by rounded erythematous, dry, scaling patches. The lesions have a predilection for nails, scalp, genitalia, extensor surfaces, and the lumbosacral region. Accelerated epidermopoiesis is considered to be the fundamental pathologic feature in psoriasis.		03.1210
Kahler Disease
[description not available]		02.1510
Multiple Myeloma
A malignancy of mature PLASMA CELLS engaging in monoclonal immunoglobulin production. It is characterized by hyperglobulinemia, excess Bence-Jones proteins (free monoclonal IMMUNOGLOBULIN LIGHT CHAINS) in the urine, skeletal destruction, bone pain, and fractures. Other features include ANEMIA; HYPERCALCEMIA; and RENAL INSUFFICIENCY.		07.1510
Angiogenesis, Pathologic
[description not available]		02.1710