Page last updated: 2024-11-01

norfloxacin and Infections, Staphylococcal

norfloxacin has been researched along with Infections, Staphylococcal in 72 studies

Norfloxacin: A synthetic fluoroquinolone (FLUOROQUINOLONES) with broad-spectrum antibacterial activity against most gram-negative and gram-positive bacteria. Norfloxacin inhibits bacterial DNA GYRASE.
norfloxacin : A quinolinemonocarboxylic acid with broad-spectrum antibacterial activity against most gram-negative and gram-positive bacteria. Norfloxacin is bactericidal and its mode of action depends on blocking of bacterial DNA replication by binding itself to an enzyme called DNA gyrase.

Research Excerpts

ExcerptRelevanceReference
"The efficacy and safety of a 5-day course of treatment with the new oral penem agent ritipenem acoxil (500 mg three times daily) or with norfloxacin (200 mg twice daily) were assessed in a double-blind study of women with uncomplicated cystitis."9.08Interpretation of the bacteriologic outcome of antibiotic treatment for uncomplicated cystitis: impact of the definition of significant bacteriuria in a comparison of ritipenem acoxil with norfloxacin. Swedish Urinary Tract Infection Study Group. ( , 1995)
"Respiratory tract infections were treated with pefloxacin in fifteen patients, who were hospitalized in the intensive care unit and required artificial ventilation."9.06Treatment of respiratory tract infections with pefloxacin in critically ill patients hospitalized in a surgical intensive care unit. ( Boland, DM; de Jong, D; MacLaren, DM; van Gestel, WC, 1987)
"Studies on a combination therapy of fosfomycin (FOM) and norfloxacin (NFLX) against chronic otitis media were performed, and the following results were obtained."7.70[Combination effect of fosfomycin otic solution and norfloxacin against chronic otitis media]. ( Uno, Y, 1999)
"We present three cases of norfloxacin deposits after treatment of bacterial keratitis."7.69Deposits of topical norfloxacin in the treatment of bacterial keratitis. ( Benitez del Castillo, JM; Castillo, A; Diaz-Valle, D; Garcia-Sanchez, J; Sayagues, O; Toledano, N, 1997)
"Norfloxacin (NFLX), a new quinolone antibiotic agent, was evaluated for its efficacy in experimental osteomyelitis in rabbits."7.68[Therapeutic efficacy of norfloxacin for experimental osteomyelitis in rabbits]. ( Aijima, H; Kaetsu, M; Okada, J, 1992)
"treatment with norfloxacin 200 mg or 400 mg or trimethoprim/sulfamethoxazole."6.66Norfloxacin versus co-trimoxazole for treatment of urinary tract infections in adults: microbiological results of a coordinated multicentre study. ( Norrby, SR; Rylander, M; Svärd, R, 1987)
"Pefloxacin (Pef) is a new quinolone which has been shown to have good in-vitro activity against Staphylococcus aureus, and to reach high tissue concentrations."5.27Comparative efficacy of pefloxacin and six other antimicrobial agents on Staphylococcus aureus experimental abscesses. ( Bouanchaud, DH; Huet, Y; Rolin, O, 1986)
"The efficacy and safety of a 5-day course of treatment with the new oral penem agent ritipenem acoxil (500 mg three times daily) or with norfloxacin (200 mg twice daily) were assessed in a double-blind study of women with uncomplicated cystitis."5.08Interpretation of the bacteriologic outcome of antibiotic treatment for uncomplicated cystitis: impact of the definition of significant bacteriuria in a comparison of ritipenem acoxil with norfloxacin. Swedish Urinary Tract Infection Study Group. ( , 1995)
" The treatment of 37 initial febrile episodes (12 cases of septicemia, 7 infectious sites and 38 cases of fever of unknown origin) in 33 neutropenic patients (PMN leucocytes less than 500/mm3) using the combination of a third generation cephalosporin (cefotaxime or ceftazidime) and a new quinolone (pefloxacin) resulted in an 86% immediate success rate (32 cases/37)."5.06[Combination of a 3d-generation cephalosporin (cefotaxime or ceftazidime) and a new quinolone (pefloxacine) in the treatment of febrile episodes in neutropenic diseases (37 cases)]. ( Bielefeld, P; Caillot, D; Guy, H; Kazmierczak, A; Portier, H; Solary, E, 1987)
"Respiratory tract infections were treated with pefloxacin in fifteen patients, who were hospitalized in the intensive care unit and required artificial ventilation."5.06Treatment of respiratory tract infections with pefloxacin in critically ill patients hospitalized in a surgical intensive care unit. ( Boland, DM; de Jong, D; MacLaren, DM; van Gestel, WC, 1987)
"Studies on a combination therapy of fosfomycin (FOM) and norfloxacin (NFLX) against chronic otitis media were performed, and the following results were obtained."3.70[Combination effect of fosfomycin otic solution and norfloxacin against chronic otitis media]. ( Uno, Y, 1999)
"We present three cases of norfloxacin deposits after treatment of bacterial keratitis."3.69Deposits of topical norfloxacin in the treatment of bacterial keratitis. ( Benitez del Castillo, JM; Castillo, A; Diaz-Valle, D; Garcia-Sanchez, J; Sayagues, O; Toledano, N, 1997)
"Norfloxacin (NFLX), a new quinolone antibiotic agent, was evaluated for its efficacy in experimental osteomyelitis in rabbits."3.68[Therapeutic efficacy of norfloxacin for experimental osteomyelitis in rabbits]. ( Aijima, H; Kaetsu, M; Okada, J, 1992)
"The effect of a single day treatment with 600 mg norfloxacin 600 mg ofloxacin or 1,920 mg trimethoprim-sulfamethoxazol was determined on 114 patients with acute cystitis."3.67[Single day treatment in acute cystitis]. ( Kawaguchi, K; Yamaguchi, K, 1988)
"Ofloxacin, a new pyridone-carboxylic acid derivative, was evaluated in descending nephritis and subcutaneous abscess models with Staphylococcus aureus in mice in comparison with norfloxacin."3.67Chemotherapeutic efficacy of ofloxacin on renal and subcutaneous infection models with Staphylococcus aureus in mice. ( Fujimoto, T; Katami, K; Osada, Y; Sato, M; Tachizawa, H; Tsumura, M; Une, T, 1986)
"treatment with norfloxacin 200 mg or 400 mg or trimethoprim/sulfamethoxazole."2.66Norfloxacin versus co-trimoxazole for treatment of urinary tract infections in adults: microbiological results of a coordinated multicentre study. ( Norrby, SR; Rylander, M; Svärd, R, 1987)
"Diosgenin is a naturally occurring steroidal saponin that has demonstrated several pharmacological properties."1.72Evaluation of the antibacterial and inhibitory activity of NorA and MepA efflux pumps from Staphylococcus aureus by diosgenin. ( Araújo, NJS; Coutinho, HDM; da Silva, ARP; de Freitas, TS; de Sousa, EO; de Vasconcelos, JEL; do Socorro Costa, M; Filho, JMB; Maia, FPA; Pereira Junior, FN; Pinheiro, JCA; Tavares, JF, 2022)
"Feline otitis externa is a dermatological disorder with a multifactorial complex etiology."1.62Otodectic and bacterial etiology of feline otitis externa in Tripoli, Libya. ( Altaeb, AA; Bennour, EM; Duro, EM; Ellraiss, OM; Elmishri, RA; Hiblu, MA; Karim, ES, 2021)
"Gentamicin was the most efficacious agent inhibiting 78."1.48Frequency of enterotoxins, toxic shock syndrome toxin-1, and biofilm formation genes in Staphylococcus aureus isolates from cows with mastitis in the Northeast of Brazil. ( Andrade, GI; Belo, NO; Carvalho, IA; Costa, EA; Costa, FN; Pereira, LS; Santos, RL, 2018)
"Norfloxacin antibiotic was loaded into cross-linked poly(2-hydroxyethyl methacrylate) (pHEMA) gels, which were subsequently surface-modified with octadecyl isocyanate to produce a hydrophobic rate-limiting barrier controlling norfloxacin release."1.35Sustained release of antibiotic from poly(2-hydroxyethyl methacrylate) to prevent blinding infections after cataract surgery. ( Anderson, EM; Bryers, JD; Garty, S; Ma, H; Noble, ML; Ratner, BD; Shen, TT, 2009)
"Norfloxacin was marginally bound to serum protein."1.30Norfloxacin pharmacokinetics in lactating cows with sub-clinical and clinical mastitis. ( Gips, M; Soback, S, 1999)
"Levofloxacin was the most potent fluoroquinolone against both strains and its activity was not significantly affected by combination with omeprazole."1.30The effects of NorA inhibition on the activities of levofloxacin, ciprofloxacin and norfloxacin against two genetically related strains of Staphylococcus aureus in an in-vitro infection model. ( Aeschlimann, JR; Kaatz, GW; Rybak, MJ, 1999)
"Pefloxacin (Pef) is a new quinolone which has been shown to have good in-vitro activity against Staphylococcus aureus, and to reach high tissue concentrations."1.27Comparative efficacy of pefloxacin and six other antimicrobial agents on Staphylococcus aureus experimental abscesses. ( Bouanchaud, DH; Huet, Y; Rolin, O, 1986)
"Norfloxacin was ineffective at 200 mg/kg per day against E."1.27In vivo evaluation of A-56619 (difloxacin) and A-56620: new aryl-fluoroquinolones. ( Bower, RR; Chu, DT; Fernandes, PB; Jarvis, KP; Ramer, NR; Shipkowitz, N, 1986)
"Pefloxacin was given as the single drug (except in one case) to twenty-seven patients with a variety of infections (bone and/or joint: 8; respiratory tract: 6; urinary tract: 5; bacteremia: 4; meninges: 3; other: 1)."1.27[Pefloxacin: clinical experience]. ( Bertrand, A; Janbon, F; Jonquet, O; Jourdan, J; Santoni, A, 1985)

Research

Studies (72)

TimeframeStudies, this research(%)All Research%
pre-199020 (27.78)18.7374
1990's21 (29.17)18.2507
2000's6 (8.33)29.6817
2010's14 (19.44)24.3611
2020's11 (15.28)2.80

Authors

AuthorsStudies
de Souza, NJ1
Gupte, SV1
Deshpande, PK1
Desai, VN1
Bhawsar, SB1
Yeole, RD1
Shukla, MC1
Strahilevitz, J1
Hooper, DC1
Bozdogan, B1
Appelbaum, PC1
Jacobs, MR1
Shetty, N1
Patel, MV1
Jha, R1
Khorakiwala, HF1
Zhi, C2
Long, ZY2
Manikowski, A2
Brown, NC2
Tarantino, PM2
Holm, K1
Dix, EJ2
Wright, GE2
Foster, KA2
Butler, MM2
LaMarr, WA2
Skow, DJ1
Motorina, I2
Lamothe, S2
Storer, R2
Comstock, J1
Xu, WC1
Holm, KA1
Barnes, MH1
Bachand, B1
Bethell, R1
Cadilhac, C1
Charron, S1
DeMarco, CE1
Cushing, LA1
Frempong-Manso, E1
Seo, SM1
Jaravaza, TA1
Kaatz, GW4
Fontaine, F1
Héquet, A1
Voisin-Chiret, AS1
Bouillon, A1
Lesnard, A1
Cresteil, T1
Jolivalt, C1
Rault, S1
Lin, S1
Koh, JJ1
Aung, TT1
Lim, F1
Li, J1
Zou, H1
Wang, L1
Lakshminarayanan, R1
Verma, C1
Wang, Y1
Tan, DT1
Cao, D1
Beuerman, RW1
Ren, L1
Liu, S1
Tareq, FS1
Hasan, CM1
Rahman, MM1
Hanafi, MMM1
Colombi Ciacchi, L1
Michaelis, M1
Harder, T1
Tebben, J1
Islam, MT1
Spiteller, P1
Zha, GF1
Wang, SM1
Rakesh, KP1
Bukhari, SNA1
Manukumar, HM1
Vivek, HK1
Mallesha, N1
Qin, HL1
Yu, JH1
Xu, XF1
Hou, W1
Meng, Y1
Huang, MY1
Lin, J1
Chen, WM1
Anafo, RB1
Atiase, Y1
Kotey, FCN1
Dayie, NTKD1
Tetteh-Quarcoo, PB1
Duodu, S1
Osei, MM1
Alzahrani, KJ1
Donkor, ES1
Mahey, N1
Tambat, R1
Chandal, N1
Verma, DK1
Thakur, KG1
Nandanwar, H1
Xavier, MR1
Freitas, TS2
Pereira, RLS2
Marinho, EM1
Bandeira, PN2
de Sousa, AP1
Oliveira, LS1
Bezerra, LL1
Neto, JBA1
Silva, MMC1
Cruz, BG1
Rocha, JE2
Barbosa, CRS1
da Silva, AW1
de Menezes, JESA1
Coutinho, HDM4
Marinho, MM2
Marinho, ES2
Dos Santos, HS2
Teixeira, AMR2
de Freitas, TS2
Xavier, JC1
Pereira Junior, FN2
Nogueira, CES1
Rodrigues, LG1
de Lacerda, BCGV1
de Andrade, EM1
do Socorro Costa, M1
da Silva, ARP1
Araújo, NJS1
Filho, JMB1
Tavares, JF1
de Sousa, EO1
Maia, FPA1
de Vasconcelos, JEL1
Pinheiro, JCA1
Cai, D1
Yang, Y1
Lu, J1
Yuan, Z1
Zhang, Y1
Yang, X1
Huang, X1
Li, T1
Tian, X1
Xu, B1
Wang, P1
Lei, H1
Lima Junior, PS1
Nascimento, HJL1
Nascimento de Sousa, J1
Araújo de Alcântara Oliveira, F1
Maria Duarte Lemos, G1
de Andrade Ferreira Barreto, J1
Kenned Silva Moura, A1
Haydée Lima Ferreira, J1
das Graças Lopes Citó, AM1
de Oliveira, MM1
Emidio Sampaio Nogueira, C1
Douglas Melo Coutinho, H1
Medeiros Barreto, H1
Martin, ALAR1
De Menezes, IRA1
Sousa, AK1
Farias, PAM1
Dos Santos, FAV1
Figueredo, FG1
Ribeiro-Filho, J1
Carvalho, DT1
Fonteles, MMF1
Sun, ZL1
Sun, SC1
He, JM1
Lan, JE1
Gibbons, S1
Mu, Q1
Hiblu, MA1
Ellraiss, OM1
Karim, ES1
Elmishri, RA1
Duro, EM1
Altaeb, AA1
Bennour, EM1
Gupta, P1
Patel, DK1
Gupta, VK2
Pal, A2
Tandon, S1
Darokar, MP2
Lowrence, RC1
Ramakrishnan, A1
Sundaramoorthy, NS1
Shyam, A1
Mohan, V1
Subbarao, HMV1
Ulaganathan, V1
Raman, T1
Solomon, A1
Nagarajan, S1
Costa, FN1
Belo, NO1
Costa, EA1
Andrade, GI1
Pereira, LS1
Carvalho, IA1
Santos, RL1
Silva, SWC1
Monção, NBN1
Araújo, BQ1
Arcanjo, DDR1
Ferreira, JHL1
Lima Neto, JS1
Citó, AMGL1
de Siqueira Júnior, JP1
Barreto, HM1
Sinha, S1
Kumar, P1
Kumar, R1
Joshi, R1
Guo, Y1
Xu, T1
Bao, C1
Liu, Z1
Fan, J1
Yang, R1
Qin, S1
Matias, EF1
Santos, KK1
Falcão-Silva, VS1
Siqueira-Junior, JP1
Costa, JG1
Coutinho, HD1
Azad, CS1
Bhunia, SS1
Krishna, A1
Shukla, PK1
Saxena, AK1
Bert, F1
Leflon-Guibout, V1
Le Grand, J1
Bourdon, N1
Nicolas-Chanoine, MH1
Anderson, EM1
Noble, ML1
Garty, S1
Ma, H1
Bryers, JD1
Shen, TT1
Ratner, BD1
Filocamo, A1
Bisignano, C1
D'Arrigo, M1
Ginestra, G1
Mandalari, G1
Galati, EM1
González-Chomón, C1
Braga, ME1
de Sousa, HC1
Concheiro, A1
Alvarez-Lorenzo, C1
Allemandi, DA1
Alovero, FL1
Manzo, RH1
Hori, S1
Ohshita, Y1
Utsui, Y1
Hiramatsu, K1
Tankovic, J1
Desplaces, N1
Duval, J1
Courvalin, P1
Cogollos, R1
Alós, JI1
Gómez-Garcés, JL1
Bow, EJ1
Mandell, LA1
Louie, TJ1
Feld, R1
Palmer, M1
Zee, B1
Pater, J1
Aguilar, L1
Balcabao, IP1
Salvá, P1
Martín, M1
Costa, J1
Prieto, J1
Dal-ré, R1
Castillo, A1
Benitez del Castillo, JM1
Toledano, N1
Diaz-Valle, D1
Sayagues, O1
Garcia-Sanchez, J1
Martino, R1
Subira, M1
Altés, A1
López, R1
Sureda, A1
Domingo-Albós, A1
Pericas, R1
Brunet, S1
Aeschlimann, JR2
Dresser, LD1
Rybak, MJ2
Uno, Y1
Gips, M1
Soback, S2
Li, XH1
Tian, ZM1
Miao, H1
Yu, LX1
Guo, HY1
Brodsky, A1
Melero, M1
Vay, C1
Okada, J1
Kaetsu, M1
Aijima, H1
Saginur, R1
Nicolle, LE1
Huber-Spitzy, V1
Baumgartner, I1
Arocker-Mettinger, E1
Schiffbänker, M1
Georgiew, L1
Grabner, G1
Shah, PM3
Yoshida, S1
Kojima, T1
Inoue, M1
Mitsuhashi, S1
Ziv, G1
Winkler, M1
Saran, A1
Moran, DB1
Ziegler, CB1
Dunne, TS1
Kuck, NA1
Lin, YI1
Prieur, B1
Di Menza, C1
Charlot, J1
Klastersky, J1
Van der Auwera, P1
Rolin, O1
Huet, Y1
Bouanchaud, DH1
Guy, H1
Caillot, D1
Solary, E1
Bielefeld, P1
Portier, H1
Kazmierczak, A1
Yamaguchi, K1
Kawaguchi, K1
Schmeiser, T1
Kurrle, E1
Arnold, R1
Wiesneth, M1
Bunjes, D1
Hertenstein, B1
Kern, W1
Heit, W1
Heimpel, H1
Michéa-Hamzehpour, M1
Pechère, JC1
Marchou, B1
Auckenthaler, R1
Esko, E1
Renkonen, OV1
Bayer, AS1
Greenberg, DP1
Yih, J1
Thauvin, C1
Lemeland, JF1
Humbert, G1
Fillastre, JP1
Denis, F1
Mounier, M1
Adenis, JP1
Rylander, M1
Norrby, SR1
Svärd, R1
Boland, DM1
van Gestel, WC1
MacLaren, DM1
de Jong, D1
Sheikh, MA1
Naqvi, SA1
Fujimoto, T1
Sato, M1
Katami, K1
Osada, Y1
Tsumura, M1
Tachizawa, H1
Une, T1
Fernandes, PB1
Chu, DT1
Bower, RR1
Jarvis, KP1
Ramer, NR1
Shipkowitz, N1
Modak, S1
Fox, CL1
Babu, SC1
Sampath, L1
Clauss, RH1
Stahl, WM1
Bertrand, A1
Janbon, F1
Jourdan, J1
Jonquet, O1
Santoni, A1

Reviews

2 reviews available for norfloxacin and Infections, Staphylococcal

ArticleYear
[Emergence of vancomycin-dependent enterococci following glycopeptide therapy: case report and review].
    Pathologie-biologie, 2009, Volume: 57, Issue:1

    Topics: Bacterial Proteins; Bacteriuria; Carbon-Oxygen Ligases; Cecal Diseases; Ceftriaxone; Citrobacter fre

2009
Cephalosporins, vancomycin, aminoglycosides and other drugs, especially in combination, for the treatment of methicillin-resistant staphylococcal infections.
    The Journal of antimicrobial chemotherapy, 1986, Volume: 17 Suppl A

    Topics: Aminoglycosides; Anti-Bacterial Agents; Cephalosporins; Drug Therapy, Combination; Glycopeptides; Im

1986

Trials

7 trials available for norfloxacin and Infections, Staphylococcal

ArticleYear
Interpretation of the bacteriologic outcome of antibiotic treatment for uncomplicated cystitis: impact of the definition of significant bacteriuria in a comparison of ritipenem acoxil with norfloxacin. Swedish Urinary Tract Infection Study Group.
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 1995, Volume: 20, Issue:3

    Topics: Adolescent; Adult; Aged; Anti-Bacterial Agents; Bacteriuria; Cystitis; Data Interpretation, Statisti

1995
Quinolone-based antibacterial chemoprophylaxis in neutropenic patients: effect of augmented gram-positive activity on infectious morbidity. National Cancer Institute of Canada Clinical Trials Group.
    Annals of internal medicine, 1996, Aug-01, Volume: 125, Issue:3

    Topics: Adult; Aged; Anti-Infective Agents; Antineoplastic Agents; Bacteremia; Colony Count, Microbial; Fema

1996
Ex vivo antibacterial properties of rufloxacin compared with those of norfloxacin in a study with healthy volunteers.
    Antimicrobial agents and chemotherapy, 1996, Volume: 40, Issue:1

    Topics: Adult; Anti-Infective Agents; Bacteriuria; Cross-Over Studies; Escherichia coli Infections; Fluoroqu

1996
Single-dose compared with 3-day norfloxacin treatment of uncomplicated urinary tract infection in women. Canadian Infectious Diseases Society Clinical Trials Study Group.
    Archives of internal medicine, 1992, Volume: 152, Issue:6

    Topics: Acute Disease; Adult; Age Factors; Aged; Aged, 80 and over; Double-Blind Method; Drug Administration

1992
[Combination of a 3d-generation cephalosporin (cefotaxime or ceftazidime) and a new quinolone (pefloxacine) in the treatment of febrile episodes in neutropenic diseases (37 cases)].
    Presse medicale (Paris, France : 1983), 1987, Dec-16, Volume: 16, Issue:43

    Topics: Agranulocytosis; Anti-Infective Agents; Cefotaxime; Ceftazidime; Drug Evaluation; Drug Therapy, Comb

1987
Norfloxacin versus co-trimoxazole for treatment of urinary tract infections in adults: microbiological results of a coordinated multicentre study.
    Scandinavian journal of infectious diseases, 1987, Volume: 19, Issue:5

    Topics: Anti-Bacterial Agents; Clinical Trials as Topic; Double-Blind Method; Drug Combinations; Escherichia

1987
Treatment of respiratory tract infections with pefloxacin in critically ill patients hospitalized in a surgical intensive care unit.
    Pharmaceutisch weekblad. Scientific edition, 1987, Dec-11, Volume: 9 Suppl

    Topics: Bacterial Infections; Clinical Trials as Topic; Critical Care; Drug Resistance, Microbial; Humans; N

1987

Other Studies

63 other studies available for norfloxacin and Infections, Staphylococcal

ArticleYear
A chiral benzoquinolizine-2-carboxylic acid arginine salt active against vancomycin-resistant Staphylococcus aureus.
    Journal of medicinal chemistry, 2005, Aug-11, Volume: 48, Issue:16

    Topics: Animals; Anti-Bacterial Agents; Area Under Curve; Clinical Trials, Phase I as Topic; Dogs; Drug Resi

2005
Synthesis and antibacterial activity of 3-substituted-6-(3-ethyl-4-methylanilino)uracils.
    Journal of medicinal chemistry, 2005, Nov-03, Volume: 48, Issue:22

    Topics: Aniline Compounds; Animals; Anti-Bacterial Agents; DNA Polymerase III; Gram-Positive Bacteria; Mice;

2005
Hybrid antibacterials. DNA polymerase-topoisomerase inhibitors.
    Journal of medicinal chemistry, 2006, Feb-23, Volume: 49, Issue:4

    Topics: Aniline Compounds; Animals; Anti-Bacterial Agents; DNA Polymerase III; Drug Resistance, Bacterial; G

2006
Efflux-related resistance to norfloxacin, dyes, and biocides in bloodstream isolates of Staphylococcus aureus.
    Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:9

    Topics: Anti-Bacterial Agents; Bacterial Proteins; beta-Galactosidase; Coloring Agents; Culture Media; Disin

2007
Boronic species as promising inhibitors of the Staphylococcus aureus NorA efflux pump: study of 6-substituted pyridine-3-boronic acid derivatives.
    European journal of medicinal chemistry, 2015, May-05, Volume: 95

    Topics: Anti-Bacterial Agents; Bacterial Proteins; Boronic Acids; Ciprofloxacin; Humans; KB Cells; Multidrug

2015
Symmetrically Substituted Xanthone Amphiphiles Combat Gram-Positive Bacterial Resistance with Enhanced Membrane Selectivity.
    Journal of medicinal chemistry, 2017, 02-23, Volume: 60, Issue:4

    Topics: Animals; Anti-Bacterial Agents; Cornea; Drug Resistance, Bacterial; Gram-Positive Bacteria; Gram-Pos

2017
Anti-Staphylococcal Calopins from Fruiting Bodies of Caloboletus radicans.
    Journal of natural products, 2018, 02-23, Volume: 81, Issue:2

    Topics: Agaricales; Anti-Bacterial Agents; Cell Line, Tumor; Enterococcus faecalis; Fruiting Bodies, Fungal;

2018
Discovery of novel arylethenesulfonyl fluorides as potential candidates against methicillin-resistant of Staphylococcus aureus (MRSA) for overcoming multidrug resistance of bacterial infections.
    European journal of medicinal chemistry, 2019, Jan-15, Volume: 162

    Topics: Bacterial Infections; Biofilms; Drug Resistance, Multiple; Electron Transport Chain Complex Proteins

2019
Synthetic cajaninstilbene acid derivatives eradicate methicillin-resistant Staphylococcus aureus persisters and biofilms.
    European journal of medicinal chemistry, 2021, Nov-15, Volume: 224

    Topics: Animals; Anti-Bacterial Agents; Biofilms; Cell Survival; Cell Wall; Disease Models, Animal; Methicil

2021
Methicillin-resistant Staphylococcus aureus (MRSA) nasal carriage among patients with diabetes at the Korle Bu Teaching Hospital.
    PloS one, 2021, Volume: 16, Issue:9

    Topics: Adolescent; Adult; Anti-Bacterial Agents; Carrier State; Clindamycin; Cross-Sectional Studies; Diabe

2021
Repurposing Approved Drugs as Fluoroquinolone Potentiators to Overcome Efflux Pump Resistance in Staphylococcus aureus.
    Microbiology spectrum, 2021, 12-22, Volume: 9, Issue:3

    Topics: Animals; Anti-Bacterial Agents; Bacterial Proteins; Biofilms; Carrier Proteins; Ciprofloxacin; Disea

2021
Anti-inflammatory effect, antibiotic potentiating activity against multidrug-resistant strains of Escherichia coli and Staphylococcus aureus, and evaluation of antibiotic resistance mechanisms by the ibuprofen derivative methyl 2-(-4-isobutylphenyl)propan
    Microbial pathogenesis, 2022, Volume: 170

    Topics: Animals; Anti-Bacterial Agents; Bacterial Proteins; Drug Resistance, Multiple, Bacterial; Escherichi

2022
ADMET study, spectroscopic characterization and effect of synthetic nitro chalcone in combination with norfloxacin, ciprofloxacin, and ethidium bromide against Staphylococcus aureus efflux pumps.
    Fundamental & clinical pharmacology, 2023, Volume: 37, Issue:1

    Topics: Anti-Bacterial Agents; Chalcone; Chalcones; Ciprofloxacin; Ethidium; Humans; Microbial Sensitivity T

2023
Evaluation of the antibacterial and inhibitory activity of NorA and MepA efflux pumps from Staphylococcus aureus by diosgenin.
    Life sciences, 2022, Nov-01, Volume: 308

    Topics: Aminoglycosides; Ampicillin; Anti-Bacterial Agents; Bacterial Proteins; beta-Lactams; Diosgenin; Esc

2022
Injectable Carrier-Free Hydrogel Dressing with Anti-Multidrug-Resistant
    ACS applied materials & interfaces, 2022, Sep-28, Volume: 14, Issue:38

    Topics: Anti-Bacterial Agents; Anti-Inflammatory Agents; Arginine; Bandages; Humans; Hydrogels; Interleukin-

2022
Inhibition of NorA efflux pump of Staphylococcus aureus by anacardic acids isolated from the cashew nutshell liquid of Anacardium occidentale L.
    Fundamental & clinical pharmacology, 2023, Volume: 37, Issue:4

    Topics: Anacardic Acids; Anacardium; Anti-Bacterial Agents; Ethidium; Microbial Sensitivity Tests; Multidrug

2023
In vitro and in silico antibacterial evaluation of coumarin derivatives against MDR strains of Staphylococcus aureus and Escherichia coli.
    Microbial pathogenesis, 2023, Volume: 177

    Topics: Anti-Bacterial Agents; Bacteria; Coumarins; Escherichia coli; Humans; Microbial Sensitivity Tests; N

2023
Synergism of sophoraflavanone G with norfloxacin against effluxing antibiotic-resistant Staphylococcus aureus.
    International journal of antimicrobial agents, 2020, Volume: 56, Issue:3

    Topics: Animals; Anti-Bacterial Agents; Drug Resistance, Multiple, Bacterial; Drug Synergism; Drug Therapy,

2020
Otodectic and bacterial etiology of feline otitis externa in Tripoli, Libya.
    Open veterinary journal, 2021, Volume: 10, Issue:4

    Topics: Animals; Anti-Bacterial Agents; Cat Diseases; Cats; Female; Gentamicins; Libya; Male; Mite Infestati

2021
Citral, a monoterpenoid aldehyde interacts synergistically with norfloxacin against methicillin resistant Staphylococcus aureus.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2017, Oct-15, Volume: 34

    Topics: Acyclic Monoterpenes; Aldehydes; Animals; Anti-Bacterial Agents; Drug Synergism; Methicillin-Resista

2017
Norfloxacin salts of carboxylic acids curtail planktonic and biofilm mode of growth in ESKAPE pathogens.
    Journal of applied microbiology, 2018, Volume: 124, Issue:2

    Topics: Acinetobacter baumannii; Animals; Anti-Bacterial Agents; Biofilms; Carboxylic Acids; Enterobacter; E

2018
Frequency of enterotoxins, toxic shock syndrome toxin-1, and biofilm formation genes in Staphylococcus aureus isolates from cows with mastitis in the Northeast of Brazil.
    Tropical animal health and production, 2018, Volume: 50, Issue:5

    Topics: Amoxicillin; Animals; Bacterial Toxins; Biofilms; Brazil; Cattle; Enterotoxins; Female; Gentamicins;

2018
Antimicrobial activity of Mimosa caesalpiniifolia Benth and its interaction with antibiotics against Staphylococcus aureus strains overexpressing efflux pump genes.
    Letters in applied microbiology, 2019, Volume: 69, Issue:1

    Topics: Anti-Bacterial Agents; Antiporters; Bacterial Proteins; Candida albicans; Ciprofloxacin; Drug Resist

2019
Usnic acid modifies MRSA drug resistance through down-regulation of proteins involved in peptidoglycan and fatty acid biosynthesis.
    FEBS open bio, 2019, Volume: 9, Issue:12

    Topics: Animals; Anti-Bacterial Agents; Benzofurans; Drug Resistance; Drug Synergism; Fatty Acids; Male; Met

2019
Design and synthesis of new norfloxacin-1,3,4-oxadiazole hybrids as antibacterial agents against methicillin-resistant Staphylococcus aureus (MRSA).
    European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2019, Aug-01, Volume: 136

    Topics: Animals; Anti-Bacterial Agents; Cell Line; Methicillin-Resistant Staphylococcus aureus; Microbial Se

2019
Modulation of the norfloxacin resistance in Staphylococcus aureus by Cordia verbenaceae DC.
    The Indian journal of medical research, 2013, Volume: 137, Issue:1

    Topics: Anti-Bacterial Agents; Cordia; Drug Resistance, Bacterial; Drug Synergism; Hexanes; Humans; Norfloxa

2013
Novel Glycoconjugate of 8-Fluoro Norfloxacin Derivatives as Gentamicin-resistant Staphylococcus aureus Inhibitors: Synthesis and Molecular Modelling Studies.
    Chemical biology & drug design, 2015, Volume: 86, Issue:4

    Topics: Drug Resistance, Bacterial; Gentamicins; Glycoconjugates; Models, Molecular; Norfloxacin; Staphyloco

2015
Sustained release of antibiotic from poly(2-hydroxyethyl methacrylate) to prevent blinding infections after cataract surgery.
    Biomaterials, 2009, Volume: 30, Issue:29

    Topics: Anti-Bacterial Agents; Deaf-Blind Disorders; Delayed-Action Preparations; Humans; Norfloxacin; Polyh

2009
Norfloxacin and ursolic acid: in vitro association and postantibiotic effect against Staphylococcus aureus.
    Letters in applied microbiology, 2011, Volume: 53, Issue:2

    Topics: Anti-Bacterial Agents; Drug Therapy, Combination; Humans; Methicillin Resistance; Microbial Sensitiv

2011
Antifouling foldable acrylic IOLs loaded with norfloxacin by aqueous soaking and by supercritical carbon dioxide technology.
    European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 2012, Volume: 82, Issue:2

    Topics: Acrylamide; Acrylic Resins; Carbon Dioxide; Hydrogels; Lenses, Intraocular; Materials Testing; Metha

2012
In-vitro activity of new sulphanilil fluoroquinolones against Staphylococcus aureus.
    The Journal of antimicrobial chemotherapy, 1994, Volume: 34, Issue:2

    Topics: Anti-Infective Agents; Ciprofloxacin; Fluoroquinolones; Humans; Hydrogen-Ion Concentration; Methicil

1994
Sequential acquisition of norfloxacin and ofloxacin resistance by methicillin-resistant and -susceptible Staphylococcus aureus.
    Antimicrobial agents and chemotherapy, 1993, Volume: 37, Issue:11

    Topics: Base Sequence; Humans; Japan; Methicillin Resistance; Microbial Sensitivity Tests; Molecular Sequenc

1993
In vivo selection during pefloxacin therapy of a mutant of Staphylococcus aureus with two mechanisms of fluoroquinolone resistance.
    Antimicrobial agents and chemotherapy, 1994, Volume: 38, Issue:5

    Topics: Anti-Infective Agents; Bacteriophage Typing; Base Sequence; Drug Resistance, Microbial; Electrophore

1994
[Evolution of fluoroquinolone sensitivity in Staphylococcus aureus isolated from hemocultures in a general hospital].
    Enfermedades infecciosas y microbiologia clinica, 1993, Volume: 11, Issue:8

    Topics: Bacteremia; Blood; Ciprofloxacin; Cross Infection; Drug Resistance, Microbial; Hospitals, General; H

1993
Deposits of topical norfloxacin in the treatment of bacterial keratitis.
    Cornea, 1997, Volume: 16, Issue:4

    Topics: Aged; Aged, 80 and over; Anti-Infective Agents; Chemical Precipitation; Cornea; Corneal Diseases; Cr

1997
Effect of discontinuing prophylaxis with norfloxacin in patients with hematologic malignancies and severe neutropenia. A matched case-control study of the effect on infectious morbidity.
    Acta haematologica, 1998, Volume: 99, Issue:4

    Topics: Adolescent; Adult; Aged; Anti-Infective Agents; Antibiotic Prophylaxis; Bacteremia; Bacterial Infect

1998
Effects of NorA inhibitors on in vitro antibacterial activities and postantibiotic effects of levofloxacin, ciprofloxacin, and norfloxacin in genetically related strains of Staphylococcus aureus.
    Antimicrobial agents and chemotherapy, 1999, Volume: 43, Issue:2

    Topics: Anti-Infective Agents; Bacterial Proteins; Biological Transport; Ciprofloxacin; Drug Synergism; Huma

1999
[Combination effect of fosfomycin otic solution and norfloxacin against chronic otitis media].
    Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases, 1999, Volume: 73, Issue:4

    Topics: Administration, Oral; Administration, Topical; Anti-Bacterial Agents; Anti-Infective Agents; Chronic

1999
Norfloxacin pharmacokinetics in lactating cows with sub-clinical and clinical mastitis.
    Journal of veterinary pharmacology and therapeutics, 1999, Volume: 22, Issue:3

    Topics: Animals; Anti-Infective Agents; Area Under Curve; Blood Proteins; Cattle; Chromatography, High Press

1999
The effects of NorA inhibition on the activities of levofloxacin, ciprofloxacin and norfloxacin against two genetically related strains of Staphylococcus aureus in an in-vitro infection model.
    The Journal of antimicrobial chemotherapy, 1999, Volume: 44, Issue:3

    Topics: Anti-Infective Agents; Bacterial Proteins; Ciprofloxacin; Drug Interactions; Drug Resistance, Microb

1999
[Studies on pyridonecarboxylic acids as antibacterial agents. XII. Synthesis and antibacterial activity of 6-chloro-1-cyclopropyl-7-(1-piperazinyl)-1, 4-dihydro-4-oxo-quinoline-3-carboxylic acid and analogues].
    Yao xue xue bao = Acta pharmaceutica Sinica, 1997, Volume: 32, Issue:11

    Topics: Animals; Anti-Infective Agents; Carboxylic Acids; Ciprofloxacin; Escherichia coli; Mice; Norfloxacin

1997
[Methicillin-resistant Staphylococcus aureus infection in neutropenic patients during norfloxacin prophylaxis].
    Medicina, 1992, Volume: 52, Issue:3

    Topics: Adult; Fatal Outcome; Female; Humans; Immunocompromised Host; Methicillin Resistance; Middle Aged; N

1992
[Therapeutic efficacy of norfloxacin for experimental osteomyelitis in rabbits].
    The Japanese journal of antibiotics, 1992, Volume: 45, Issue:5

    Topics: Animals; Drug Evaluation; Drug Resistance, Microbial; Male; Norfloxacin; Osteomyelitis; Rabbits; Sta

1992
[Corneal ulcer. Current analysis from specialized ambulatory care of a clinic].
    Klinische Monatsblatter fur Augenheilkunde, 1992, Volume: 200, Issue:4

    Topics: Ambulatory Care; Anti-Bacterial Agents; Bacterial Infections; Contact Lenses, Extended-Wear; Corneal

1992
Oral antibiotic prophylaxis in patients with hematological diseases.
    Scandinavian journal of infectious diseases, 1991, Volume: 23, Issue:4

    Topics: Ciprofloxacin; Humans; Norfloxacin; Sepsis; Staphylococcal Infections

1991
Uptake of sparfloxacin and norfloxacin by clinical isolates of Staphylococcus aureus.
    Antimicrobial agents and chemotherapy, 1991, Volume: 35, Issue:2

    Topics: Anti-Infective Agents; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Drug Resistance, Microbial; Fluoro

1991
Systemic dry cow therapy--a preliminary report.
    Journal of dairy science, 1990, Volume: 73, Issue:3

    Topics: Animals; Cattle; Cephalosporins; Cephapirin; Female; Injections, Intramuscular; Injections, Subcutan

1990
Synthesis of novel 5-fluoro analogues of norfloxacin and ciprofloxacin.
    Journal of medicinal chemistry, 1989, Volume: 32, Issue:6

    Topics: Animals; Chemical Phenomena; Chemistry; Ciprofloxacin; Enterobacter; Enterococcus faecalis; Escheric

1989
The role of quinolones in staphylococcal infection.
    Journal of chemotherapy (Florence, Italy), 1989, Volume: 1, Issue:4

    Topics: Anti-Infective Agents; Ciprofloxacin; Enoxacin; Humans; Norfloxacin; Ofloxacin; Pefloxacin; Staphylo

1989
[Passage of pefloxacine into the synovial fluid].
    Presse medicale (Paris, France : 1983), 1985, Nov-16, Volume: 14, Issue:39

    Topics: Anti-Infective Agents; Arthritis, Infectious; Female; Humans; Norfloxacin; Pefloxacin; Staphylococca

1985
Comparative efficacy of pefloxacin and six other antimicrobial agents on Staphylococcus aureus experimental abscesses.
    The Journal of antimicrobial chemotherapy, 1986, Volume: 17 Suppl B

    Topics: Abscess; Administration, Oral; Animals; Anti-Bacterial Agents; Cephalothin; Ciprofloxacin; Injection

1986
[Single day treatment in acute cystitis].
    Hinyokika kiyo. Acta urologica Japonica, 1988, Volume: 34, Issue:5

    Topics: Acute Disease; Adolescent; Adult; Aged; Aged, 80 and over; Anti-Infective Agents, Urinary; Cystitis;

1988
Norfloxacin for prevention of bacterial infections during severe granulocytopenia after bone marrow transplantation.
    Scandinavian journal of infectious diseases, 1988, Volume: 20, Issue:6

    Topics: Adolescent; Adult; Agranulocytosis; Bacterial Infections; Bone Marrow Transplantation; Female; Human

1988
Combination therapy: a way to limit emergence of resistance?
    The American journal of medicine, 1986, Jun-30, Volume: 80, Issue:6B

    Topics: Amikacin; Animals; Anti-Bacterial Agents; Ceftriaxone; Drug Resistance, Microbial; Drug Therapy, Com

1986
Comparative in vitro activity of norfloxacin and seven other antimicrobial agents against clinical isolates from urinary tract infections.
    Scandinavian journal of infectious diseases, 1985, Volume: 17, Issue:1

    Topics: Anti-Infective Agents, Urinary; Cefaclor; Enterobacteriaceae; Enterobacteriaceae Infections; Humans;

1985
Correlates of therapeutic efficacy in experimental methicillin-resistant Staphylococcus aureus endocarditis.
    Chemotherapy, 1988, Volume: 34, Issue:1

    Topics: Animals; Anti-Infective Agents; Endocarditis, Bacterial; Methicillin; Microbial Sensitivity Tests; N

1988
Efficacy of pefloxacin-fosfomycin in experimental endocarditis caused by methicillin-resistant Staphylococcus aureus.
    Antimicrobial agents and chemotherapy, 1988, Volume: 32, Issue:6

    Topics: Animals; Anti-Infective Agents; Endocarditis, Bacterial; Fosfomycin; Male; Methicillin; Norfloxacin;

1988
[Intraocular penetration of pefloxacin in man and rabbit. The aqueous humor and vitreous body].
    Pathologie-biologie, 1987, Volume: 35, Issue:5 Pt 2

    Topics: Adult; Aged; Aged, 80 and over; Animals; Anti-Infective Agents; Aqueous Humor; Humans; Middle Aged;

1987
A study of the use of norfloxacin in prostatitis.
    Chemioterapia : international journal of the Mediterranean Society of Chemotherapy, 1987, Volume: 6, Issue:2 Suppl

    Topics: Adult; Escherichia coli Infections; Humans; Male; Norfloxacin; Prostatitis; Staphylococcal Infection

1987
Chemotherapeutic efficacy of ofloxacin on renal and subcutaneous infection models with Staphylococcus aureus in mice.
    Chemotherapy, 1986, Volume: 32, Issue:3

    Topics: Abscess; Animals; Anti-Bacterial Agents; Autoradiography; Disease Models, Animal; Kinetics; Male; Mi

1986
In vivo evaluation of A-56619 (difloxacin) and A-56620: new aryl-fluoroquinolones.
    Antimicrobial agents and chemotherapy, 1986, Volume: 29, Issue:2

    Topics: Animals; Anti-Infective Agents; Bacteria; Bacterial Infections; Ciprofloxacin; Enterobacteriaceae In

1986
PTFE graft treated with silver norfloxacin (AgNF): drug retention and resistance to bacterial challenge.
    The Journal of surgical research, 1987, Volume: 42, Issue:3

    Topics: Animals; Anti-Infective Agents; Blood Vessel Prosthesis; Dogs; Escherichia coli Infections; Fluoroqu

1987
[Pefloxacin: clinical experience].
    Pathologie-biologie, 1985, Volume: 33, Issue:5 Pt 2

    Topics: Acinetobacter Infections; Adult; Aged; Bacterial Infections; Enterobacteriaceae Infections; Enteroco

1985