norfloxacin has been researched along with Seizures in 17 studies
Norfloxacin: A synthetic fluoroquinolone (FLUOROQUINOLONES) with broad-spectrum antibacterial activity against most gram-negative and gram-positive bacteria. Norfloxacin inhibits bacterial DNA GYRASE.
norfloxacin : A quinolinemonocarboxylic acid with broad-spectrum antibacterial activity against most gram-negative and gram-positive bacteria. Norfloxacin is bactericidal and its mode of action depends on blocking of bacterial DNA replication by binding itself to an enzyme called DNA gyrase.
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Therefore, norfloxacin-inducted seizures are not triggered by intracerebral glutamate level enhancement." | 5.32 | Norfloxacin-induced electroencephalogram alteration and seizures in rats are not triggered by enhanced levels of intracerebral glutamate. ( Chenel, M; Couet, W; Limosin, A; Marchand, S; Mimoz, O; Paquereau, J, 2003) |
| " Pharmacokinetic studies demonstrated that THEO serum levels and elimination were not altered by concurrent CP administration." | 5.28 | Effects of fluoroquinolone antimicrobials alone and in conjunction with theophylline on seizures in amygdaloid kindled rats. Mechanistic and pharmacokinetic study. ( Schwark, WS; Vancutsem, PM, 1992) |
| " The model was used to characterize the additivity (or non-additivity) of norfloxacin, pefloxacin, and theophylline in causing maximal seizures in male Sprague Dawley rats." | 3.72 | Extension of the isobolographic approach to interactions studies between more than two drugs: illustration with the convulsant interaction between pefloxacin, norfloxacin, and theophylline in rats. ( Bois, FY; Brochot, C; Couet, W; Gelman, A; Marchand, S, 2004) |
| "The clinical risk of convulsion for each combination was estimated using a pharmacodynamic model based on receptor occupancy using the in vitro data set obtained and pharmacokinetic parameters in humans collected from the literature." | 1.35 | Quantitative comparison of the convulsive activity of combinations of twelve fluoroquinolones with five nonsteroidal antiinflammatory agents. ( Kim, J; Ohtani, H; Sawada, Y; Tsujimoto, M, 2009) |
| "Norfloxacin provoked clonic convulsions in rats treated concomitantly with biphenylacetic acid, a major metabolite of the nonsteroidal anti-inflammatory drug fenbufen." | 1.33 | Changes in brain interleukin-1beta following the coadministration of norfloxacin with biphenylacetic acid in rats. ( Chen, BY; Cheng, NN; Li, XT; Tang, WL; Wang, YM; Zhang, LR, 2006) |
| " There is a significant correlation between AUC(0-infinity) and the changes of relative total power, which may serve as the index for judgement and prediction of the CNS toxic effect induced by NFLX." | 1.32 | Neurotoxicity and toxicokinetics of norfloxacin in conscious rats. ( Chen, BY; Cheng, NN; Wang, YM; Zhang, LR, 2003) |
| "Therefore, norfloxacin-inducted seizures are not triggered by intracerebral glutamate level enhancement." | 1.32 | Norfloxacin-induced electroencephalogram alteration and seizures in rats are not triggered by enhanced levels of intracerebral glutamate. ( Chenel, M; Couet, W; Limosin, A; Marchand, S; Mimoz, O; Paquereau, J, 2003) |
| "Convulsant activity of pazufloxacin mesilate (PZFX mesilate), a new quinolone antibacterial agent for intravenous use, in combination with nonsteroidal anti-inflammatory drug (NSAID) was investigated in mice after intravenous or intracerebroventricular administration." | 1.31 | [Drug interactions between nonsteroidal anti-inflammatory drug and pazufloxacin mesilate, a new quinolone antibacterial agent for intravenous use: convulsions in mice after intravenous or intracerebroventricular administration]. ( Fukuda, H; Kawamura, Y, 2002) |
| "These findings showed that the quantitative isobolographic approach is appropriate to assess the nature and intensity of the pharmacodynamic interaction between two drugs when data are collected within the biophase, but that data interpretation outside the biophase can be risky due to further pharmacokinetic complexities, in particular slow or/and nonlinear diffusion into the biophase." | 1.31 | Ignoring pharmacokinetics may lead to isoboles misinterpretation: illustration with the norfloxacin-theophylline convulsant interaction in rats. ( Bouquet, S; Cadart, M; Couet, W; Marchand, S; Pariat, C, 2002) |
| " Doses of pefloxacin and concentrations in cerebrospinal fluid and plasma (total and unbound) at the pharmacodynamic endpoint were all independent of infusion rate, whereas only cerebrospinal fluid concentrations of norfloxacin were independent of infusion rate." | 1.30 | Pharmacokinetic-pharmacodynamic contributions to the convulsant activity of pefloxacin and norfloxacin in rats. ( Bouquet, S; Couet, W; Courtois, P; Delon, A; Huguet, F; Vierfond, JM, 1997) |
| "CSF concentration of ENX at the time of convulsion in clinical situation approximated the IC50 of ENX for the GABA response." | 1.30 | Inhibitory effect of new quinolones on GABA(A) receptor-mediated response and its potentiation with felbinac in Xenopus oocytes injected with mouse-brain mRNA: correlation with convulsive potency in vivo. ( Asanuma, A; Iga, T; Kawakami, J; Sawada, Y; Yamamoto, K; Yanagisawa, K, 1997) |
| "The incidence of these convulsions was enhanced by the combination with BPAA (50 micrograms)." | 1.29 | Levofloxacin, an optical isomer of ofloxacin, has attenuated epileptogenic activity in mice and inhibitory potency in GABA receptor binding. ( Akahane, K; Kimura, Y; Kitano, Y; Tsutomi, Y, 1994) |
| " Pharmacokinetic studies demonstrated that THEO serum levels and elimination were not altered by concurrent CP administration." | 1.28 | Effects of fluoroquinolone antimicrobials alone and in conjunction with theophylline on seizures in amygdaloid kindled rats. Mechanistic and pharmacokinetic study. ( Schwark, WS; Vancutsem, PM, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (5.88) | 18.7374 |
| 1990's | 6 (35.29) | 18.2507 |
| 2000's | 8 (47.06) | 29.6817 |
| 2010's | 2 (11.76) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Aly, MM | 1 |
| Mohamed, YA | 1 |
| El-Bayouki, KA | 1 |
| Basyouni, WM | 1 |
| Abbas, SY | 1 |
| Sharma, S | 1 |
| Srinivasaraghavan, R | 1 |
| Krishnamurthy, S | 1 |
| Kim, J | 1 |
| Ohtani, H | 1 |
| Tsujimoto, M | 1 |
| Sawada, Y | 2 |
| Fukuda, H | 2 |
| Kawamura, Y | 1 |
| Zhang, LR | 2 |
| Wang, YM | 2 |
| Chen, BY | 2 |
| Cheng, NN | 2 |
| Chenel, M | 1 |
| Limosin, A | 1 |
| Marchand, S | 4 |
| Paquereau, J | 1 |
| Mimoz, O | 1 |
| Couet, W | 5 |
| Brochot, C | 1 |
| Gelman, A | 1 |
| Bois, FY | 1 |
| Li, XT | 1 |
| Tang, WL | 1 |
| Akahane, K | 2 |
| Kimura, Y | 2 |
| Tsutomi, Y | 2 |
| Hayakawa, I | 1 |
| Kitano, Y | 1 |
| Delon, A | 1 |
| Huguet, F | 1 |
| Courtois, P | 2 |
| Vierfond, JM | 1 |
| Bouquet, S | 3 |
| Kawakami, J | 1 |
| Yamamoto, K | 1 |
| Asanuma, A | 1 |
| Yanagisawa, K | 1 |
| Iga, T | 1 |
| Ito, Y | 1 |
| Ishige, K | 1 |
| Aizawa, M | 1 |
| Pariat, C | 2 |
| Cadart, M | 1 |
| Vancutsem, PM | 1 |
| Schwark, WS | 1 |
| Anastasio, GD | 1 |
| Menscer, D | 1 |
| Little, JM | 1 |
17 other studies available for norfloxacin and Seizures
| Article | Year |
|---|---|
Synthesis of some new 4(3H)-quinazolinone-2-carboxaldehyde thiosemicarbazones and their metal complexes and a study on their anticonvulsant, analgesic, cytotoxic and antimicrobial activities - part-1.
Topics: Analgesics; Animals; Anti-Infective Agents; Anticonvulsants; Antineoplastic Agents; Bacteria; Cell L | 2010 |
Central Nervous System Symptoms Due to Transient Methemoglobinemia in a Child With G6PD Deficiency.
Topics: Acute Disease; Child, Preschool; Consanguinity; Cyanosis; Glucosephosphate Dehydrogenase Deficiency; | 2017 |
Quantitative comparison of the convulsive activity of combinations of twelve fluoroquinolones with five nonsteroidal antiinflammatory agents.
Topics: Animals; Anti-Bacterial Agents; Anti-Infective Agents; Anti-Inflammatory Agents, Non-Steroidal; Cipr | 2009 |
[Drug interactions between nonsteroidal anti-inflammatory drug and pazufloxacin mesilate, a new quinolone antibacterial agent for intravenous use: convulsions in mice after intravenous or intracerebroventricular administration].
Topics: Administration, Oral; Animals; Anti-Bacterial Agents; Anti-Infective Agents; Anti-Inflammatory Agent | 2002 |
Neurotoxicity and toxicokinetics of norfloxacin in conscious rats.
Topics: Animals; Anti-Infective Agents; Area Under Curve; Dose-Response Relationship, Drug; Electroencephalo | 2003 |
Norfloxacin-induced electroencephalogram alteration and seizures in rats are not triggered by enhanced levels of intracerebral glutamate.
Topics: Animals; Anti-Infective Agents; Area Under Curve; Brain Chemistry; Electroencephalography; Glutamic | 2003 |
Extension of the isobolographic approach to interactions studies between more than two drugs: illustration with the convulsant interaction between pefloxacin, norfloxacin, and theophylline in rats.
Topics: Animals; Drug Interactions; Male; Norfloxacin; Pefloxacin; Rats; Rats, Sprague-Dawley; Seizures; The | 2004 |
Changes in brain interleukin-1beta following the coadministration of norfloxacin with biphenylacetic acid in rats.
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents, Non-Steroidal; Brain; Drug Interactions; E | 2006 |
Possible intermolecular interaction between quinolones and biphenylacetic acid inhibits gamma-aminobutyric acid receptor sites.
Topics: Animals; Binding Sites; Drug Interactions; GABA Antagonists; Magnetic Resonance Spectroscopy; Muscim | 1994 |
Levofloxacin, an optical isomer of ofloxacin, has attenuated epileptogenic activity in mice and inhibitory potency in GABA receptor binding.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cisterna Magna; GABA Antagonists; In Vitro Techniq | 1994 |
Pharmacokinetic-pharmacodynamic contributions to the convulsant activity of pefloxacin and norfloxacin in rats.
Topics: 4-Quinolones; Animals; Anti-Infective Agents; Brain; Convulsants; Fluoroquinolones; Infusions, Intra | 1997 |
Inhibitory effect of new quinolones on GABA(A) receptor-mediated response and its potentiation with felbinac in Xenopus oocytes injected with mouse-brain mRNA: correlation with convulsive potency in vivo.
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents, Non-Steroidal; Bicuculline; Brain Chemistr | 1997 |
Characterization of quinolone antibacterial-induced convulsions and increases in nuclear AP-1 DNA- and CRE-binding activities in mouse brain.
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents, Non-Steroidal; Brain; Cyclic AMP Receptor | 1999 |
Pharmacokinetic-pharmacodynamic modelling of the convulsant interaction between norfloxacin and biphenyl acetic acid in rats.
Topics: Animals; Convulsants; Drug Interactions; Male; Norfloxacin; Phenylacetates; Rats; Rats, Sprague-Dawl | 2000 |
Ignoring pharmacokinetics may lead to isoboles misinterpretation: illustration with the norfloxacin-theophylline convulsant interaction in rats.
Topics: Algorithms; Animals; Anti-Infective Agents; Bronchodilator Agents; Chromatography, High Pressure Liq | 2002 |
Effects of fluoroquinolone antimicrobials alone and in conjunction with theophylline on seizures in amygdaloid kindled rats. Mechanistic and pharmacokinetic study.
Topics: 2-Chloroadenosine; Amygdala; Animals; Anti-Infective Agents; Chromatography, High Pressure Liquid; D | 1992 |
Norfloxacin and seizures.
Topics: Female; Humans; Middle Aged; Norfloxacin; Seizures | 1988 |