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wck 771

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Description

WCK 771: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	9850037
CHEMBL ID	190465
SCHEMBL ID	5213674
MeSH ID	M0473216

Synonyms (14)

Synonym
CHEMBL190465
u2rv55f5o0 ,
306748-89-0
wck 771
l-arginine, mono((5s)-9-fluoro-6,7-dihydro-8-(4-hydroxy-1-piperidinyl)-5-methyl-1-oxo-1h,5h-benzo(ij)quinolizine-2-carboxylate)
levonadifloxacin arginine salt
unii-u2rv55f5o0
l-arginine, (5s)-9-fluoro-6,7-dihydro-8-(4-hydroxy-1-piperidinyl)-5-methyl-1-oxo-1h,5h-benzo(ij)quinolizine-2-carboxylate (1:1)
levonadifloxacin arginine
SCHEMBL5213674
DTXSID60184714
l-arginine compound with (s)-9-fluoro-8-(4-hydroxypiperidin-1-yl)-5-methyl-1-oxo-6,7-dihydro-1h,5h-pyrido[3,2,1-ij]quinoline-2-carboxylic acid (1:1)
(2s)-2-amino-5-(diaminomethylideneamino)pentanoic acid;(12s)-7-fluoro-8-(4-hydroxypiperidin-1-yl)-12-methyl-4-oxo-1-azatricyclo[7.3.1.05,13]trideca-2,5,7,9(13)-tetraene-3-carboxylic acid
Q27290601

Research Excerpts

Overview

WCK 771 is a broad-spectrum fluoroquinolone with enhanced activity against quinolone-resistant staphylococci. It has recently completed a phase III trial in India.

Excerpt	Reference	Relevance
"WCK 771 is an l-arginine salt of levonadifloxacin (LND) being developed in intravenous dosage form and has recently completed a phase III trial in India. "	( Identification of metabolites of novel Anti-MRSA fluoroquinolone WCK 771 in mouse, rat, rabbit, dog, monkey and human urine using liquid chromatography tandem mass spectrometry. Ahirrao, VK; Chavan, RP; Deshpande, PK; Patel, AM; Patel, MV; Patil, KR; Rane, VP; Yeole, RD, 2019)	2.19
"WCK 771 is a broad-spectrum fluoroquinolone with enhanced activity against quinolone-resistant staphylococci. "	( The anti-methicillin-resistant Staphylococcus aureus quinolone WCK 771 has potent activity against sequentially selected mutants, has a narrow mutant selection window against quinolone-resistant Staphylococcus aureus, and preferentially targets DNA gyrase Bhagwat, SS; Gupte, SV; Khorakiwala, HF; Mundkur, LA; Patel, MV, 2006)	2.02

Dosage Studied

Excerpt	Relevance	Reference
"WCK 771 is an l-arginine salt of levonadifloxacin (LND) being developed in intravenous dosage form and has recently completed a phase III trial in India."	( Identification of metabolites of novel Anti-MRSA fluoroquinolone WCK 771 in mouse, rat, rabbit, dog, monkey and human urine using liquid chromatography tandem mass spectrometry. Ahirrao, VK; Chavan, RP; Deshpande, PK; Patel, AM; Patel, MV; Patil, KR; Rane, VP; Yeole, RD, 2019)	2.19

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (22)

Assay ID	Title	Year	Journal	Article
AID246899	Protection of mice infected with MRSA-32 cell suspension after oral administration of compound	2005	Journal of medicinal chemistry, Aug-11, Volume: 48, Issue:16	A chiral benzoquinolizine-2-carboxylic acid arginine salt active against vancomycin-resistant Staphylococcus aureus.
AID544291	Antibacterial activity against Staphylococcus aureus after 24 hrs by CLSI method	2009	Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2	In vitro activity of the quinolone WCK 771 against recent U.S. hospital and community-acquired Staphylococcus aureus pathogens with various resistance types.
AID544303	Antibacterial activity against vancomycin-resistant Staphylococcus aureus VRS3 harboring GyrA S84L and GrlA S80F, E84K mutant after 24 hrs by CLSI method	2009	Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2	In vitro activity of the quinolone WCK 771 against recent U.S. hospital and community-acquired Staphylococcus aureus pathogens with various resistance types.
AID544308	AUC in human at 800 mg, iv qd after 24 hrs	2009	Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2	In vitro activity of the quinolone WCK 771 against recent U.S. hospital and community-acquired Staphylococcus aureus pathogens with various resistance types.
AID544294	Antibacterial activity against hospital acquired methicillin-resistant Staphylococcus aureus after 24 hrs by CLSI method	2009	Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2	In vitro activity of the quinolone WCK 771 against recent U.S. hospital and community-acquired Staphylococcus aureus pathogens with various resistance types.
AID544295	Antibacterial activity against vancomycin-intermediate Staphylococcus aureus after 24 hrs by CLSI method	2009	Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2	In vitro activity of the quinolone WCK 771 against recent U.S. hospital and community-acquired Staphylococcus aureus pathogens with various resistance types.
AID544310	Ratio of AUC in human to MIC for Staphylococcus aureus after 24 hrs	2009	Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2	In vitro activity of the quinolone WCK 771 against recent U.S. hospital and community-acquired Staphylococcus aureus pathogens with various resistance types.
AID544292	Antibacterial activity against methicillin-susceptible Staphylococcus aureus after 24 hrs by CLSI method	2009	Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2	In vitro activity of the quinolone WCK 771 against recent U.S. hospital and community-acquired Staphylococcus aureus pathogens with various resistance types.
AID544309	Fraction unbound in human at 800 mg, iv qd after 24 hrs	2009	Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2	In vitro activity of the quinolone WCK 771 against recent U.S. hospital and community-acquired Staphylococcus aureus pathogens with various resistance types.
AID544293	Antibacterial activity against community acquired methicillin-resistant Staphylococcus aureus after 24 hrs by CLSI method	2009	Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2	In vitro activity of the quinolone WCK 771 against recent U.S. hospital and community-acquired Staphylococcus aureus pathogens with various resistance types.
AID544299	Antibacterial activity against vancomycin-intermediate Staphylococcus aureus Mu3 harboring GyrA S84L and GrlA S80F mutant after 24 hrs by CLSI method	2009	Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2	In vitro activity of the quinolone WCK 771 against recent U.S. hospital and community-acquired Staphylococcus aureus pathogens with various resistance types.
AID544302	Antibacterial activity against vancomycin-resistant Staphylococcus aureus VRS2 harboring GyrA S84L and GrlA S80F mutant after 24 hrs by CLSI method	2009	Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2	In vitro activity of the quinolone WCK 771 against recent U.S. hospital and community-acquired Staphylococcus aureus pathogens with various resistance types.
AID544296	Antibacterial activity against quinolone-resistant Staphylococcus aureus after 24 hrs by CLSI method	2009	Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2	In vitro activity of the quinolone WCK 771 against recent U.S. hospital and community-acquired Staphylococcus aureus pathogens with various resistance types.
AID544304	Antibacterial activity against vancomycin-resistant Staphylococcus aureus VRS5 harboring GyrA S84L, E88K and GrlA S80F, E84G mutant after 24 hrs by CLSI method	2009	Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2	In vitro activity of the quinolone WCK 771 against recent U.S. hospital and community-acquired Staphylococcus aureus pathogens with various resistance types.
AID544301	Antibacterial activity against vancomycin-resistant Staphylococcus aureus VRS1 harboring GyrA S84L and GrlA S80F mutant after 24 hrs by CLSI method	2009	Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2	In vitro activity of the quinolone WCK 771 against recent U.S. hospital and community-acquired Staphylococcus aureus pathogens with various resistance types.
AID544297	Antibacterial activity against vancomycin-susceptible methicillin-resistant Staphylococcus aureus 32 harboring GyrA S84L and GrlA S80Y mutant after 24 hrs by CLSI method	2009	Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2	In vitro activity of the quinolone WCK 771 against recent U.S. hospital and community-acquired Staphylococcus aureus pathogens with various resistance types.
AID544305	Antibacterial activity against vancomycin-resistant Staphylococcus aureus VRS6 harboring GyrA S84L and GrlA S80F, E84G mutant after 24 hrs by CLSI method	2009	Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2	In vitro activity of the quinolone WCK 771 against recent U.S. hospital and community-acquired Staphylococcus aureus pathogens with various resistance types.
AID544306	Antibacterial activity against vancomycin-resistant Staphylococcus aureus VRS7 harboring GyrA S84L and GrlA S80F mutant after 24 hrs by CLSI method	2009	Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2	In vitro activity of the quinolone WCK 771 against recent U.S. hospital and community-acquired Staphylococcus aureus pathogens with various resistance types.
AID544300	Antibacterial activity against vancomycin-intermediate Staphylococcus aureus Mu50 harboring GyrA S84L and GrlA S80F mutant after 24 hrs by CLSI method	2009	Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2	In vitro activity of the quinolone WCK 771 against recent U.S. hospital and community-acquired Staphylococcus aureus pathogens with various resistance types.
AID544307	Antibacterial activity against vancomycin-resistant Staphylococcus aureus VRS4 harboring GyrA S84L and GrlA S80F, E84K mutant after 24 hrs by CLSI method	2009	Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2	In vitro activity of the quinolone WCK 771 against recent U.S. hospital and community-acquired Staphylococcus aureus pathogens with various resistance types.
AID244913	Minimum inhibitory concentration against methicillin susceptible Staphylococcus aureus	2005	Journal of medicinal chemistry, Aug-11, Volume: 48, Issue:16	A chiral benzoquinolizine-2-carboxylic acid arginine salt active against vancomycin-resistant Staphylococcus aureus.
AID544298	Antibacterial activity against vancomycin-susceptible methicillin-resistant Staphylococcus aureus 34 harboring GyrA S84L and GrlA S80F mutant after 24 hrs by CLSI method	2009	Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2	In vitro activity of the quinolone WCK 771 against recent U.S. hospital and community-acquired Staphylococcus aureus pathogens with various resistance types.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (15)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	11 (73.33)	29.6817
2010's	4 (26.67)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 11.56

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	11.56 (24.57)
Research Supply Index	2.77 (2.92)
Research Growth Index	4.33 (4.65)
Search Engine Demand Index	0.00 (26.88)
Search Engine Supply Index	0.00 (0.95)

This Compound (11.56)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	1 (6.67%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	14 (93.33%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
ciprofloxacin Ciprofloxacin: A broad-spectrum antimicrobial carboxyfluoroquinoline.. ciprofloxacin : A quinolone that is quinolin-4(1H)-one bearing cyclopropyl, carboxylic acid, fluoro and piperazin-1-yl substituents at positions 1, 3, 6 and 7, respectively.	2.02	1	aminoquinoline; cyclopropanes; fluoroquinolone antibiotic; N-arylpiperazine; quinolinemonocarboxylic acid; quinolone antibiotic; quinolone; zwitterion	antibacterial drug; antiinfective agent; antimicrobial agent; DNA synthesis inhibitor; EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor; environmental contaminant; topoisomerase IV inhibitor; xenobiotic
nadifloxacin nadifloxacin: (R)-isomer does not induce chromosomal aberrations, unlike (S)-isomer; structure given in first source	8.81	3	heteroarylpiperidine; hydroxypiperidine; pyridoquinoline; quinolone antibiotic	antibacterial drug
norfloxacin Norfloxacin: A synthetic fluoroquinolone (FLUOROQUINOLONES) with broad-spectrum antibacterial activity against most gram-negative and gram-positive bacteria. Norfloxacin inhibits bacterial DNA GYRASE.. norfloxacin : A quinolinemonocarboxylic acid with broad-spectrum antibacterial activity against most gram-negative and gram-positive bacteria. Norfloxacin is bactericidal and its mode of action depends on blocking of bacterial DNA replication by binding itself to an enzyme called DNA gyrase.	2.02	1	fluoroquinolone antibiotic; N-arylpiperazine; quinolinemonocarboxylic acid; quinolone antibiotic; quinolone	antibacterial drug; DNA synthesis inhibitor; environmental contaminant; xenobiotic
gatifloxacin Gatifloxacin: A fluoroquinolone antibacterial agent and DNA TOPOISOMERASE II inhibitor that is used as an ophthalmic solution for the treatment of BACTERIAL CONJUNCTIVITIS.. gatifloxacin : A monocarboxylic acid that is 4-oxo-1,4-dihydroquinoline-3-carboxylic acid which is substituted on the nitrogen by a cyclopropyl group and at positions 6, 7, and 8 by fluoro, 3-methylpiperazin-1-yl, and methoxy groups, respectively. Gatifloxacin is an antibiotic of the fourth-generation fluoroquinolone family, that like other members of that family, inhibits the bacterial topoisomerase type-II enzymes.	2.02	1	N-arylpiperazine; organofluorine compound; quinolinemonocarboxylic acid; quinolone antibiotic; quinolone	antiinfective agent; antimicrobial agent; EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor
carbostyril Quinolones: A group of derivatives of naphthyridine carboxylic acid, quinoline carboxylic acid, or NALIDIXIC ACID.. quinolin-2(1H)-one : A quinolone that is 1,2-dihydroquinoline substituted by an oxo group at position 2.	2.97	4	monohydroxyquinoline; quinolone	bacterial xenobiotic metabolite
methicillin Methicillin: One of the PENICILLINS which is resistant to PENICILLINASE but susceptible to a penicillin-binding protein. It is inactivated by gastric acid so administered by injection.. methicillin : A penicillin that is 6-aminopenicillanic acid in which one of the amino hydrogens is replaced by a 2,6-dimethoxybenzoyl group.	7.21	1	penicillin allergen; penicillin	antibacterial drug
vancomycin Vancomycin: Antibacterial obtained from Streptomyces orientalis. It is a glycopeptide related to RISTOCETIN that inhibits bacterial cell wall assembly and is toxic to kidneys and the inner ear.. vancomycin : A complex glycopeptide from Streptomyces orientalis. It inhibits a specific step in the synthesis of the peptidoglycan layer in the Gram-positive bacteria Staphylococcus aureus and Clostridium difficile.	2.44	2	glycopeptide	antibacterial drug; antimicrobial agent; bacterial metabolite
pefloxacin Pefloxacin: A synthetic broad-spectrum fluoroquinolone antibacterial agent active against most gram-negative and gram-positive bacteria.. pefloxacin : A quinolone that is 4-oxo-1,4-dihydroquinoline which is substituted at positions 1, 3, 6 and 7 by ethyl, carboxy, fluorine, and 4-methylpiperazin-1-yl groups, respectively.	2.02	1	fluoroquinolone antibiotic; monocarboxylic acid; N-alkylpiperazine; N-arylpiperazine; quinolone antibiotic; quinolone	antibacterial drug; antiinfective agent; DNA synthesis inhibitor
sparfloxacin [no description available]	2.02	1	fluoroquinolone antibiotic; N-arylpiperazine; quinolinemonocarboxylic acid; quinolone antibiotic; quinolone
trovafloxacin trovafloxacin: a trifluoronaphthyridone derivative of 7-(3-azabicyclo(3.1.0)hexyl)naphthyridone; has antineoplastic activity. trovafloxacin : A 1,8-naphthyridine derivative that is 4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid bearing additional 2,4-difluorophenyl, fluoro and 6-amino-3-azabicyclo[3.1.0]hex-3-yl substituents at positions 1, 6 and 7 respectively. A broad-spectrum antibiotic that was withdrawn from the market due to risk of liver failure.	2.02	1
levofloxacin Levofloxacin: The L-isomer of Ofloxacin.. levofloxacin : An optically active form of ofloxacin having (S)-configuration; an inhibitor of bacterial topoisomerase IV and DNA gyrase.	2.02	1	9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid; fluoroquinolone antibiotic; quinolone antibiotic	antibacterial drug; DNA synthesis inhibitor; EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor; topoisomerase IV inhibitor
moxifloxacin Moxifloxacin: A fluoroquinolone that acts as an inhibitor of DNA TOPOISOMERASE II and is used as a broad-spectrum antibacterial agent.. moxifloxacin : A quinolone that consists of 4-oxo-1,4-dihydroquinoline-3-carboxylic acid bearing a cyclopropyl substituent at position 1, a fluoro substitiuent at position 6, a (4aS,7aS)-octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl group at position 7 and a methoxy substituent at position 8. A member of the fluoroquinolone class of antibacterial agents.	2.44	2	aromatic ether; cyclopropanes; fluoroquinolone antibiotic; pyrrolidinopiperidine; quinolinemonocarboxylic acid; quinolone antibiotic; quinolone	antibacterial drug
linezolid [no description available]	2.02	1	acetamides; morpholines; organofluorine compound; oxazolidinone	antibacterial drug; protein synthesis inhibitor
betadex beta-Cyclodextrins: Cyclic GLUCANS consisting of seven (7) glucopyranose units linked by 1,4-glycosidic bonds.	2.03	1	cyclodextrin
(S)-nadifloxacin levonadifloxacin: broad-spectrum anti-MRSA benzoquinolizine quinolone agent	2.02	1	nadifloxacin
ly-146032 [no description available]	2.02	1	heterodetic cyclic peptide; lipopeptide antibiotic; lipopeptide; macrocycle; macrolide	antibacterial drug; bacterial metabolite; calcium-dependent antibiotics
piperidines Piperidines: A family of hexahydropyridines.	2.02	1

Condition	Relationship Strength	Studies
Infections, Staphylococcal [description not available]	3.14	5
Staphylococcal Infections Infections with bacteria of the genus STAPHYLOCOCCUS.	3.14	5
Health Care Associated Infection [description not available]	2.05	1
Cross Infection Any infection which a patient contracts in a health-care institution.	2.05	1
Infections, Chlamydia [description not available]	2.21	1
Chlamydia Infections Infections with bacteria of the genus CHLAMYDIA.	2.21	1
Bacterial Disease [description not available]	2.02	1
Bacterial Infections Infections by bacteria, general or unspecified.	2.02	1
Blood Poisoning [description not available]	2.02	1
Phlegmon [description not available]	2.02	1
Cellulitis An acute, diffuse, and suppurative inflammation of loose connective tissue, particularly the deep subcutaneous tissues, and sometimes muscle, which is most commonly seen as a result of infection of a wound, ulcer, or other skin lesions.	2.02	1
Sepsis Systemic inflammatory response syndrome with a proven or suspected infectious etiology. When sepsis is associated with organ dysfunction distant from the site of infection, it is called severe sepsis. When sepsis is accompanied by HYPOTENSION despite adequate fluid infusion, it is called SEPTIC SHOCK.	2.02	1
Pneumonia, Pneumococcal A febrile disease caused by STREPTOCOCCUS PNEUMONIAE.	2.02	1
Bacteremia The presence of viable bacteria circulating in the blood. Fever, chills, tachycardia, and tachypnea are common acute manifestations of bacteremia. The majority of cases are seen in already hospitalized patients, most of whom have underlying diseases or procedures which render their bloodstreams susceptible to invasion.	2.02	1
Sore Throat [description not available]	2.02	1
Infections, Pneumococcal [description not available]	2.02	1
Injuries Used with anatomic headings, animals, and sports for wounds and injuries. Excludes cell damage, for which pathology is used.	2.02	1
Group A Strep Infection [description not available]	2.02	1
Pharyngitis Inflammation of the throat (PHARYNX).	2.02	1
Pneumococcal Infections Infections with bacteria of the species STREPTOCOCCUS PNEUMONIAE.	2.02	1
Streptococcal Infections Infections with bacteria of the genus STREPTOCOCCUS.	2.02	1
Tonsillitis Inflammation of the tonsils, especially the PALATINE TONSILS but the ADENOIDS (pharyngeal tonsils) and lingual tonsils may also be involved. Tonsillitis usually is caused by bacterial infection. Tonsillitis may be acute, chronic, or recurrent.	2.02	1
Wounds and Injuries Damage inflicted on the body as the direct or indirect result of an external force, with or without disruption of structural continuity.	2.02	1
Sensitivity and Specificity Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)	2.44	2
Acne [description not available]	2.94	1
Infections, Staphylococcal Skin [description not available]	2.94	1
Acne Vulgaris A chronic disorder of the pilosebaceous apparatus associated with an increase in sebum secretion. It is characterized by open comedones (blackheads), closed comedones (whiteheads), and pustular nodules. The cause is unknown, but heredity and age are predisposing factors.	2.94	1
Staphylococcal Skin Infections Infections to the skin caused by bacteria of the genus STAPHYLOCOCCUS.	2.94	1

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