norfloxacin has been researched along with Pregnancy in 16 studies
Norfloxacin: A synthetic fluoroquinolone (FLUOROQUINOLONES) with broad-spectrum antibacterial activity against most gram-negative and gram-positive bacteria. Norfloxacin inhibits bacterial DNA GYRASE.
norfloxacin : A quinolinemonocarboxylic acid with broad-spectrum antibacterial activity against most gram-negative and gram-positive bacteria. Norfloxacin is bactericidal and its mode of action depends on blocking of bacterial DNA replication by binding itself to an enzyme called DNA gyrase.
Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Crede's method was evaluated using norfloxacin (NFLX) and gentamicin (GM) to show the clinical significance of chemoprophylaxis against ophthalmia neonatorum occurring through vertical infections." | 7.68 | [Chemoprophylaxis of ophthalmia neonatorum through vertical infection. Evaluation of Crede's method using norfloxacin and gentamicin]. ( Seiga, K; Shoji, T, 1993) |
| "Crede's method was evaluated using norfloxacin (NFLX) and gentamicin (GM) to show the clinical significance of chemoprophylaxis against ophthalmia neonatorum occurring through vertical infections." | 3.68 | [Chemoprophylaxis of ophthalmia neonatorum through vertical infection. Evaluation of Crede's method using norfloxacin and gentamicin]. ( Seiga, K; Shoji, T, 1993) |
| "Norfloxacin method is a simple, inexpensive and automatable kinetic assay." | 1.34 | A kinetic method amenable to automation for ceruloplasmin estimation with inexpensive and stable reagents. ( Ambade, V; Somani, BL, 2007) |
| " Overall, results indicated (1) no marked differences in pharmacokinetic parameters in pregnant versus nonpregnant females, (2) fleroxacin levels in embryonic tissues were similar to maternal plasma levels, and (3) there was a correlation between exposure and embryolethal doses for all fluoroquinolones which resulted in embryolethality except norfloxacin." | 1.29 | Developmental toxicity of fleroxacin and comparative pharmacokinetics of four fluoroquinolones in the cynomolgus macaque (Macaca fascicularis). ( Hendrickx, AG; Hummler, H; Richter, WF, 1993) |
| " The results of these studies combined suggest that the developmental toxic effects observed in prior studies and Study I are specific to pregnancy and directly related to placental-derived P production." | 1.28 | Embryotoxicity studies of norfloxacin in cynomolgus monkeys. II. Role of progesterone. ( Cukierski, MA; Hendrickx, AG; Hess, DL; Lasley, BL; Peter, CP; Prahalada, S; Robertson, RT; Tarantal, AF; Tarara, R, 1992) |
| " Forty-six pregnant monkeys were dosed with a control vehicle or 200 mg/kg/day norfloxacin for one of three 10-day periods on GD 36-45, 71-80, or 111-120." | 1.28 | Embryotoxicity studies of norfloxacin in cynomolgus monkeys: I. Teratology studies and norfloxacin plasma concentration in pregnant and nonpregnant monkeys. ( Cukierski, MA; Cukierski, MJ; Hess, DL; Nyland, T; Peter, CP; Prahalada, S; Robertson, RT; Rodgers, JD; Tarantal, AF; Zacchei, AG, 1989) |
| "Norfloxacin is a new antibiotic which caused embryo-fetal toxicity in association with maternotoxicity when given orally to rabbits at 100 mg/kg/day." | 1.27 | Association between adverse maternal and embryo-fetal effects in norfloxacin-treated and food-deprived rabbits. ( Bland, JA; Bokelman, DL; Clark, RL; Nolan, TE; Oppenheimer, L; Peter, CP; Robertson, RT, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (25.00) | 18.7374 |
| 1990's | 9 (56.25) | 18.2507 |
| 2000's | 1 (6.25) | 29.6817 |
| 2010's | 1 (6.25) | 24.3611 |
| 2020's | 1 (6.25) | 2.80 |
| Authors | Studies |
|---|---|
| Lin, J | 1 |
| Ding, J | 1 |
| Di, X | 1 |
| Sun, W | 1 |
| Chen, H | 1 |
| Zhang, H | 1 |
| Gauld, NJ | 1 |
| Zeng, IS | 1 |
| Ikram, RB | 1 |
| Thomas, MG | 1 |
| Buetow, SA | 1 |
| Somani, BL | 1 |
| Ambade, V | 1 |
| Maura, A | 2 |
| Pino, A | 2 |
| Gardella, A | 1 |
| Falugi, C | 1 |
| Berkovitch, M | 1 |
| Pastuszak, A | 1 |
| Gazarian, M | 1 |
| Lewis, M | 1 |
| Koren, G | 2 |
| Hummler, H | 1 |
| Richter, WF | 1 |
| Hendrickx, AG | 2 |
| Seiga, K | 1 |
| Shoji, T | 1 |
| Wilton, LV | 1 |
| Pearce, GL | 1 |
| Mann, RD | 1 |
| Cukierski, MA | 2 |
| Prahalada, S | 2 |
| Tarantal, AF | 2 |
| Hess, DL | 2 |
| Lasley, BL | 1 |
| Peter, CP | 3 |
| Tarara, R | 1 |
| Robertson, RT | 3 |
| Salmerón, JM | 1 |
| Titó, L | 1 |
| Rimola, A | 1 |
| Mas, A | 1 |
| Navasa, MA | 1 |
| Llach, J | 1 |
| Ginès, A | 1 |
| Ginès, P | 1 |
| Arroyo, V | 1 |
| Rodés, J | 1 |
| Villa, F | 1 |
| Masciangelo, L | 1 |
| Iatrakis, G | 1 |
| Kourounis, G | 1 |
| Georgoulias, N | 1 |
| Filippidis, I | 1 |
| Louvrou, N | 1 |
| Deligianis, V | 1 |
| Zacchei, AG | 1 |
| Rodgers, JD | 1 |
| Cukierski, MJ | 1 |
| Nyland, T | 1 |
| Bertrand, A | 1 |
| Janbon, F | 1 |
| Jonquet, O | 1 |
| Reynes, J | 1 |
| Clark, RL | 1 |
| Bland, JA | 1 |
| Nolan, TE | 1 |
| Oppenheimer, L | 1 |
| Bokelman, DL | 1 |
2 trials available for norfloxacin and Pregnancy
| Article | Year |
|---|---|
Safety of the new quinolones in pregnancy.
Topics: Abnormalities, Drug-Induced; Adult; Ciprofloxacin; Female; Humans; Infant, Newborn; Musculoskeletal | 1994 |
Selective intestinal decontamination in the prevention of bacterial infection in patients with acute liver failure.
Topics: Adult; Bacterial Infections; Colistin; Enterobacteriaceae; Female; Gram-Negative Bacteria; Gram-Posi | 1992 |
14 other studies available for norfloxacin and Pregnancy
| Article | Year |
|---|---|
Association between prenatal antibiotics exposure and measures of fetal growth: A repeated-measure study.
Topics: Anti-Bacterial Agents; Birth Weight; Ciprofloxacin; Female; Fetal Development; Humans; Infant, Newbo | 2022 |
Treatment of uncomplicated cystitis: analysis of prescribing in New Zealand.
Topics: Adolescent; Adult; Aged; Anti-Infective Agents; Cystitis; Dose-Response Relationship, Drug; Drug Pre | 2016 |
A kinetic method amenable to automation for ceruloplasmin estimation with inexpensive and stable reagents.
Topics: Adult; Ceruloplasmin; Clinical Chemistry Tests; Dithiothreitol; Female; Ferrozine; Hepatolenticular | 2007 |
Micronucleus formation in fetal maternal rat erythroblasts after norfloxacin transplacental administration.
Topics: Animals; Erythroblasts; Female; Fetus; Liver; Maternal-Fetal Exchange; Micronucleus Tests; Mutagens; | 1994 |
Developmental toxicity of fleroxacin and comparative pharmacokinetics of four fluoroquinolones in the cynomolgus macaque (Macaca fascicularis).
Topics: Administration, Oral; Animals; Anti-Infective Agents; Ciprofloxacin; Embryo, Mammalian; Female; Fler | 1993 |
[Chemoprophylaxis of ophthalmia neonatorum through vertical infection. Evaluation of Crede's method using norfloxacin and gentamicin].
Topics: Adult; Female; Gentamicins; Humans; Infant, Newborn; Norfloxacin; Ophthalmia Neonatorum; Pregnancy | 1993 |
Use of the new quinolones during pregnancy.
Topics: Abnormalities, Drug-Induced; Anti-Infective Agents; Child, Preschool; Ciprofloxacin; Female; Follow- | 1996 |
A comparison of ciprofloxacin, norfloxacin, ofloxacin, azithromycin and cefixime examined by observational cohort studies.
Topics: Adult; Anti-Bacterial Agents; Anti-Infective Agents; Azithromycin; Cefixime; Cefotaxime; Ciprofloxac | 1996 |
Embryotoxicity studies of norfloxacin in cynomolgus monkeys. II. Role of progesterone.
Topics: Animals; Chorionic Gonadotropin; Corpus Luteum; Estradiol; Female; Fetal Death; Gestational Age; Mac | 1992 |
Evaluation of DNA damage induced by norfloxacin in liver and kidney of adult rats and in fetal tissues after transplacental exposure.
Topics: Animals; DNA Damage; Female; Kidney; Liver; Maternal-Fetal Exchange; Norfloxacin; Pregnancy; Rats; R | 1991 |
[Treatment of urinary infections in pregnant women].
Topics: Ampicillin; Female; Humans; Norfloxacin; Pregnancy; Pregnancy Complications, Infectious; Pyelonephri | 1989 |
Embryotoxicity studies of norfloxacin in cynomolgus monkeys: I. Teratology studies and norfloxacin plasma concentration in pregnant and nonpregnant monkeys.
Topics: Animals; Body Weight; Embryonic and Fetal Development; Female; Macaca fascicularis; Maternal-Fetal E | 1989 |
[Rickettsiaceae infections and fluoroquinolones].
Topics: Administration, Oral; Adult; Aged; Anti-Infective Agents; Boutonneuse Fever; Drug Evaluation; Drug T | 1988 |
Association between adverse maternal and embryo-fetal effects in norfloxacin-treated and food-deprived rabbits.
Topics: Animals; Bile; Body Weight; Embryonic and Fetal Development; Female; Fetal Resorption; Food Deprivat | 1986 |