norfloxacin has been researched along with Disease Models, Animal in 23 studies
Norfloxacin: A synthetic fluoroquinolone (FLUOROQUINOLONES) with broad-spectrum antibacterial activity against most gram-negative and gram-positive bacteria. Norfloxacin inhibits bacterial DNA GYRASE.
norfloxacin : A quinolinemonocarboxylic acid with broad-spectrum antibacterial activity against most gram-negative and gram-positive bacteria. Norfloxacin is bactericidal and its mode of action depends on blocking of bacterial DNA replication by binding itself to an enzyme called DNA gyrase.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Many antibiotics at appropriate concentrations improved the survival rate and alleviated tissue injury, while, when dosing strategies fall below subtherapeutic levels, worse therapeutic effects are seen." | 5.46 | Low-dose norfloxacin and ciprofloxacin therapy worsen leptospirosis in hamster. ( Cao, Y; Guo, J; Jin, X; Lin, T; Wang, T; Wu, D; Wu, R; Xie, X; Zhang, W, 2017) |
| " In the survival study, a dose-response effect of ciprofloxacin on survival was observed (ciprofloxacin: 10 mg/kg, 10%; 50 mg/kg, 26%; and 100 mg/kg, 35%) with the results in the 100-mg/kg-treated group being significant when compared with the 5% survival rate in saline-treated controls (P < ." | 5.30 | The beneficial effects of ciprofloxacin on survival and hepatic regenerative activity in a rat model of fulminant hepatic failure. ( Assy, N; Gauthier, T; Kaita, KD; Meyers, AF; Minuk, GY; Zhang, M, 1998) |
| "Ofloxacin, a new pyridone-carboxylic acid derivative, was evaluated in descending nephritis and subcutaneous abscess models with Staphylococcus aureus in mice in comparison with norfloxacin." | 3.67 | Chemotherapeutic efficacy of ofloxacin on renal and subcutaneous infection models with Staphylococcus aureus in mice. ( Fujimoto, T; Katami, K; Osada, Y; Sato, M; Tachizawa, H; Tsumura, M; Une, T, 1986) |
| " Many antibiotics at appropriate concentrations improved the survival rate and alleviated tissue injury, while, when dosing strategies fall below subtherapeutic levels, worse therapeutic effects are seen." | 1.46 | Low-dose norfloxacin and ciprofloxacin therapy worsen leptospirosis in hamster. ( Cao, Y; Guo, J; Jin, X; Lin, T; Wang, T; Wu, D; Wu, R; Xie, X; Zhang, W, 2017) |
| "The aac(6')-Ib-cr gene, in spite of producing low-level resistance by itself, plays a relevant role in acquisition of a clinical level of ciprofloxacin and norfloxacin resistance, when combined with three or four chromosomal mutations, both in vitro and in vivo." | 1.43 | Impact of AAC(6')-Ib-cr in combination with chromosomal-mediated mechanisms on clinical quinolone resistance in Escherichia coli. ( Díaz-De-Alba, P; Docobo-Perez, F; Machuca, J; Ortiz, M; Pascual, Á; Recacha, E; Rodríguez-Martínez, JM, 2016) |
| " In the survival study, a dose-response effect of ciprofloxacin on survival was observed (ciprofloxacin: 10 mg/kg, 10%; 50 mg/kg, 26%; and 100 mg/kg, 35%) with the results in the 100-mg/kg-treated group being significant when compared with the 5% survival rate in saline-treated controls (P < ." | 1.30 | The beneficial effects of ciprofloxacin on survival and hepatic regenerative activity in a rat model of fulminant hepatic failure. ( Assy, N; Gauthier, T; Kaita, KD; Meyers, AF; Minuk, GY; Zhang, M, 1998) |
| "Norfloxacin was substantially more effective than trimethoprim-sulphamethoxazole in reducing the number of colony forming units from kidney homogenates when the test animals were diabetic." | 1.27 | Norfloxacin versus trimethoprim-sulphamethoxazole: efficacy in a model of ascending urinary tract infection in normal and streptozotocin-induced diabetic mice. ( Abruzzo, GK; Fromtling, RA; Gadebusch, HH; Gilfillan, EC; Pelak, BA, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (17.39) | 18.7374 |
| 1990's | 4 (17.39) | 18.2507 |
| 2000's | 4 (17.39) | 29.6817 |
| 2010's | 6 (26.09) | 24.3611 |
| 2020's | 5 (21.74) | 2.80 |
| Authors | Studies |
|---|---|
| O'Donnell, G | 1 |
| Poeschl, R | 1 |
| Zimhony, O | 1 |
| Gunaratnam, M | 1 |
| Moreira, JB | 1 |
| Neidle, S | 1 |
| Evangelopoulos, D | 1 |
| Bhakta, S | 1 |
| Malkinson, JP | 1 |
| Boshoff, HI | 1 |
| Lenaerts, A | 1 |
| Gibbons, S | 1 |
| Avdeef, A | 1 |
| Tam, KY | 1 |
| Abrams, RPM | 1 |
| Yasgar, A | 1 |
| Teramoto, T | 1 |
| Lee, MH | 1 |
| Dorjsuren, D | 1 |
| Eastman, RT | 1 |
| Malik, N | 1 |
| Zakharov, AV | 1 |
| Li, W | 1 |
| Bachani, M | 1 |
| Brimacombe, K | 1 |
| Steiner, JP | 1 |
| Hall, MD | 1 |
| Balasubramanian, A | 1 |
| Jadhav, A | 1 |
| Padmanabhan, R | 1 |
| Simeonov, A | 1 |
| Nath, A | 1 |
| Yu, JH | 1 |
| Xu, XF | 1 |
| Hou, W | 1 |
| Meng, Y | 1 |
| Huang, MY | 1 |
| Lin, J | 1 |
| Chen, WM | 1 |
| Turcu, AL | 1 |
| Companys-Alemany, J | 1 |
| Phillips, MB | 1 |
| Patel, DS | 1 |
| Griñán-Ferré, C | 1 |
| Loza, MI | 1 |
| Brea, JM | 1 |
| Pérez, B | 1 |
| Soto, D | 1 |
| Sureda, FX | 1 |
| Kurnikova, MG | 1 |
| Johnson, JW | 1 |
| Pallàs, M | 1 |
| Vázquez, S | 1 |
| Mahey, N | 1 |
| Tambat, R | 1 |
| Chandal, N | 1 |
| Verma, DK | 1 |
| Thakur, KG | 1 |
| Nandanwar, H | 1 |
| Singh, S | 1 |
| Verma, S | 1 |
| Yadav, DK | 1 |
| Kumar, A | 1 |
| Tyagi, R | 1 |
| Gupta, P | 1 |
| Bawankule, DU | 1 |
| Darokar, MP | 1 |
| Srivastava, SK | 1 |
| Kalra, A | 1 |
| Naguib, MM | 1 |
| Valvano, MA | 1 |
| Zhang, W | 2 |
| Zhang, N | 1 |
| Wang, W | 1 |
| Wang, F | 1 |
| Gong, Y | 1 |
| Jiang, H | 1 |
| Zhang, Z | 1 |
| Liu, X | 1 |
| Song, X | 1 |
| Wang, T | 2 |
| Ding, Z | 1 |
| Cao, Y | 2 |
| Machuca, J | 1 |
| Ortiz, M | 1 |
| Recacha, E | 1 |
| Díaz-De-Alba, P | 1 |
| Docobo-Perez, F | 1 |
| Rodríguez-Martínez, JM | 1 |
| Pascual, Á | 1 |
| Wu, D | 1 |
| Lin, T | 1 |
| Jin, X | 1 |
| Xie, X | 1 |
| Guo, J | 1 |
| Wu, R | 1 |
| Kishii, R | 1 |
| Takei, M | 1 |
| Shah, N | 1 |
| Dhar, D | 1 |
| El Zahraa Mohammed, F | 1 |
| Habtesion, A | 1 |
| Davies, NA | 1 |
| Jover-Cobos, M | 1 |
| Macnaughtan, J | 1 |
| Sharma, V | 1 |
| Olde Damink, SWM | 1 |
| Mookerjee, RP | 1 |
| Jalan, R | 1 |
| Rabiller, A | 1 |
| Nunes, H | 1 |
| Lebrec, D | 1 |
| Tazi, KA | 1 |
| Wartski, M | 1 |
| Dulmet, E | 1 |
| Libert, JM | 1 |
| Mougeot, C | 1 |
| Moreau, R | 1 |
| Mazmanian, M | 1 |
| Humbert, M | 1 |
| Hervé, P | 1 |
| Alagarsamy, V | 1 |
| Murugananthan, G | 1 |
| Venkateshperumal, R | 1 |
| Chakrabarti, MK | 1 |
| Bhattacharya, MK | 1 |
| Sinha, AK | 1 |
| Chatterjee, DC | 1 |
| Bhattacharya, SK | 1 |
| Kaita, KD | 1 |
| Assy, N | 1 |
| Gauthier, T | 1 |
| Zhang, M | 1 |
| Meyers, AF | 1 |
| Minuk, GY | 1 |
| Kurioka, T | 1 |
| Yunou, Y | 1 |
| Harada, H | 1 |
| Kita, E | 1 |
| Sawamura, S | 1 |
| Tanaka, K | 1 |
| Koga, Y | 1 |
| Nord, CE | 1 |
| Edlund, C | 1 |
| Lahnborg, G | 1 |
| Gargallo, D | 1 |
| Moros, M | 1 |
| Coll, R | 1 |
| Esteve, M | 1 |
| Parés, J | 1 |
| Xicota, MA | 1 |
| Guinea, J | 1 |
| Fujimoto, T | 1 |
| Sato, M | 1 |
| Katami, K | 1 |
| Osada, Y | 1 |
| Tsumura, M | 1 |
| Tachizawa, H | 1 |
| Une, T | 1 |
| Fromtling, RA | 1 |
| Abruzzo, GK | 1 |
| Gilfillan, EC | 1 |
| Pelak, BA | 1 |
| Gadebusch, HH | 1 |
23 other studies available for norfloxacin and Disease Models, Animal
| Article | Year |
|---|---|
Bioactive pyridine-N-oxide disulfides from Allium stipitatum.
Topics: 2,2'-Dipyridyl; Alkaloids; Allium; Animals; Anti-Bacterial Agents; Antineoplastic Agents, Phytogenic | 2009 |
How well can the Caco-2/Madin-Darby canine kidney models predict effective human jejunal permeability?
Topics: Animals; Disease Models, Animal; Dogs; Humans; Jejunal Diseases; Kidney Diseases; Models, Biological | 2010 |
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
Synthetic cajaninstilbene acid derivatives eradicate methicillin-resistant Staphylococcus aureus persisters and biofilms.
Topics: Animals; Anti-Bacterial Agents; Biofilms; Cell Survival; Cell Wall; Disease Models, Animal; Methicil | 2021 |
Design, synthesis, and in vitro and in vivo characterization of new memantine analogs for Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Caenorhabditis elegans; Disease Models, Animal; Memantine; Mice; Recepto | 2022 |
Repurposing Approved Drugs as Fluoroquinolone Potentiators to Overcome Efflux Pump Resistance in Staphylococcus aureus.
Topics: Animals; Anti-Bacterial Agents; Bacterial Proteins; Biofilms; Carrier Proteins; Ciprofloxacin; Disea | 2021 |
The Bioactive Potential of Culturable Fungal Endophytes Isolated From the Leaf of Catharanthus roseus (L.) G. Don.
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Catharanthus; Cytokines; Disease Models, A | 2021 |
Vitamin E Increases Antimicrobial Sensitivity by Inhibiting Bacterial Lipocalin Antibiotic Binding.
Topics: Animals; Anti-Bacterial Agents; Bacterial Proteins; Burkholderia cenocepacia; Burkholderia Infection | 2018 |
Efficacy of cefepime, ertapenem and norfloxacin against leptospirosis and for the clearance of pathogens in a hamster model.
Topics: Animal Structures; Animals; Anti-Bacterial Agents; beta-Lactams; Cefepime; Cephalosporins; Cricetina | 2014 |
Impact of AAC(6')-Ib-cr in combination with chromosomal-mediated mechanisms on clinical quinolone resistance in Escherichia coli.
Topics: Animals; Anti-Bacterial Agents; Chromosomes, Bacterial; Ciprofloxacin; Disease Models, Animal; Esche | 2016 |
Low-dose norfloxacin and ciprofloxacin therapy worsen leptospirosis in hamster.
Topics: Animals; Anti-Bacterial Agents; Bacterial Load; Biopsy; Ciprofloxacin; Cricetinae; Cytokines; Diseas | 2017 |
Relationship between the expression of ompF and quinolone resistance in Escherichia coli.
Topics: Animals; Anti-Bacterial Agents; Cell Growth Processes; Ciprofloxacin; Disease Models, Animal; DNA Gy | 2009 |
Prevention of acute kidney injury in a rodent model of cirrhosis following selective gut decontamination is associated with reduced renal TLR4 expression.
Topics: Acute Kidney Injury; Animals; Anti-Bacterial Agents; Cytokines; Disease Models, Animal; Gastrointest | 2012 |
Prevention of gram-negative translocation reduces the severity of hepatopulmonary syndrome.
Topics: Animals; Anti-Infective Agents; Antibiotic Prophylaxis; Bacterial Translocation; Common Bile Duct; D | 2002 |
Synthesis, analgesic, anti-inflammatory and antibacterial activities of some novel 2-methyl-3-substituted quinazolin-4-(3H)-ones.
Topics: Administration, Oral; Analgesics; Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Ster | 2003 |
Evaluation of the efficacy of different antibiotics in inhibiting colonisation of Vibrio cholerae O1 in the rabbit intestine.
Topics: Animals; Anti-Bacterial Agents; Cholera; Ciprofloxacin; Disease Models, Animal; Evaluation Studies a | 1993 |
The beneficial effects of ciprofloxacin on survival and hepatic regenerative activity in a rat model of fulminant hepatic failure.
Topics: Alanine Transaminase; Animals; Anti-Infective Agents; Ciprofloxacin; Disease Models, Animal; DNA; Im | 1998 |
Efficacy of antibiotic therapy for infection with Shiga-like toxin-producing Escherichia coli O157:H7 in mice with protein-calorie malnutrition.
Topics: Ampicillin; Animals; Anti-Bacterial Agents; Bacterial Toxins; Brain Chemistry; Disease Models, Anima | 1999 |
[Therapeutic effects of antibiotics against enterohemorrhagic Escherichia coli (EHEC) O157:H7 (O157) infection: in vivo analysis using germfree mice].
Topics: Animals; Anti-Bacterial Agents; Anti-Infective Agents; Bacterial Toxins; Disease Models, Animal; Esc | 1999 |
The efficacy of pefloxacin in comparison to gentamicin in the treatment of experimentally induced peritonitis in rats.
Topics: Animals; Anti-Bacterial Agents; Bacteria, Anaerobic; Bacterial Infections; Bacteroides fragilis; Clo | 1986 |
Activity of E-3846, a new fluoroquinolone, in vitro and in experimental cystitis and pyelonephritis in rats.
Topics: Animals; Anti-Infective Agents; Anti-Infective Agents, Urinary; Bacteria; Chemical Phenomena; Chemis | 1988 |
Chemotherapeutic efficacy of ofloxacin on renal and subcutaneous infection models with Staphylococcus aureus in mice.
Topics: Abscess; Animals; Anti-Bacterial Agents; Autoradiography; Disease Models, Animal; Kinetics; Male; Mi | 1986 |
Norfloxacin versus trimethoprim-sulphamethoxazole: efficacy in a model of ascending urinary tract infection in normal and streptozotocin-induced diabetic mice.
Topics: Animals; Anti-Infective Agents; Diabetes Mellitus, Experimental; Disease Models, Animal; Drug Combin | 1985 |