norfloxacin has been researched along with Uremia in 2 studies
Norfloxacin: A synthetic fluoroquinolone (FLUOROQUINOLONES) with broad-spectrum antibacterial activity against most gram-negative and gram-positive bacteria. Norfloxacin inhibits bacterial DNA GYRASE.
norfloxacin : A quinolinemonocarboxylic acid with broad-spectrum antibacterial activity against most gram-negative and gram-positive bacteria. Norfloxacin is bactericidal and its mode of action depends on blocking of bacterial DNA replication by binding itself to an enzyme called DNA gyrase.
Uremia: A clinical syndrome associated with the retention of renal waste products or uremic toxins in the blood. It is usually the result of RENAL INSUFFICIENCY. Most uremic toxins are end products of protein or nitrogen CATABOLISM, such as UREA or CREATININE. Severe uremia can lead to multiple organ dysfunctions with a constellation of symptoms.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The pefloxacin levels were similar to those achieved in healthy subjects, but reduced renal function leads accumulation of its biotransformation products, especially of the N-oxide metabolite which lacks antibacterial activity." | 1.27 | Steady-state levels of pefloxacin and its metabolites in patients with severe renal impairment. ( Ganeval, D; Hannedouche, T; Jungers, P; Montay, G; Prieur, B, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fillastre, JP | 1 |
| Hannedouche, T | 2 |
| Leroy, A | 1 |
| Humbert, G | 1 |
| Jungers, P | 1 |
| Ganeval, D | 1 |
| Prieur, B | 1 |
| Montay, G | 1 |
2 other studies available for norfloxacin and Uremia
| Article | Year |
|---|---|
Pharmacokinetics of norfloxacin in renal failure.
Topics: Anti-Infective Agents; Humans; Kinetics; Nalidixic Acid; Norfloxacin; Uremia | 1984 |
Steady-state levels of pefloxacin and its metabolites in patients with severe renal impairment.
Topics: Administration, Oral; Adult; Aged; Anti-Infective Agents; Biological Assay; Chromatography, High Pre | 1987 |