Page last updated: 2024-12-07

e 4695

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

E 4695: structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID125566
CHEMBL ID132632
SCHEMBL ID9146820
MeSH IDM0206606

Synonyms (14)

Synonym
e4695
CHEMBL132632
e-4695
1,8-naphthyridine-3-carboxylic acid, 7-(3-amino-2-methyl-1-azetidinyl)-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-, (2s-trans)-
(2s-trans)-7-(3-amino-2-methyl-1-azetidinyl)-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid
7-(3-amino-2-methyl-1-azetidinyl)-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid
e 4695
132832-30-5
7-(3(r)-amino-2(s)-methyl-1-azetidinyl)-1 cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid
SCHEMBL9146820
DTXSID90927838
7-(3-amino-2-methylazetidin-1-yl)-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid
7-((2s,3r)-3-amino-2-methylazetidin-1-yl)-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid
7-[(2s,3r)-3-amino-2-methylazetidin-1-yl]-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (36)

Assay IDTitleYearJournalArticle
AID205747In vitro antibacterial activity measured as minimum inhibitory concentration was evaluated on Staphylococcus epidermidis ATCC 155-1 (Se).1995Journal of medicinal chemistry, Mar-31, Volume: 38, Issue:7
7-Azetidinylquinolones as antibacterial agents. 3. Synthesis, properties and structure-activity relationships of the stereoisomers containing a 7-(3-amino-2-methyl-1-azetidinyl) moiety.
AID40785In vitro minimum inhibitory concentration for Bacillus subtilis ATCC 66331994Journal of medicinal chemistry, Nov-25, Volume: 37, Issue:24
7-azetidinylquinolones as antibacterial agents. 2. Synthesis and biological activity of 7-(2,3-disubstituted-1-azetidinyl)-4-oxoquinoline- and -1,8-naphthyridine-3-carboxylic acids. Properties and structure-activity relationships of quinolones with an aze
AID21530Solubility in water was determined at 25 degrees Centigrade1995Journal of medicinal chemistry, Mar-31, Volume: 38, Issue:7
7-Azetidinylquinolones as antibacterial agents. 3. Synthesis, properties and structure-activity relationships of the stereoisomers containing a 7-(3-amino-2-methyl-1-azetidinyl) moiety.
AID95535In vitro antibacterial activity measured as minimum inhibitory concentration was evaluated on klebsiella pneumoniae ATCC 10031 (Kp).1995Journal of medicinal chemistry, Mar-31, Volume: 38, Issue:7
7-Azetidinylquinolones as antibacterial agents. 3. Synthesis, properties and structure-activity relationships of the stereoisomers containing a 7-(3-amino-2-methyl-1-azetidinyl) moiety.
AID209229In vitro antibacterial activity measured as minimum inhibitory concentration was evaluated on Streptococcus faecalis ATCC 10541 (Sf).1995Journal of medicinal chemistry, Mar-31, Volume: 38, Issue:7
7-Azetidinylquinolones as antibacterial agents. 3. Synthesis, properties and structure-activity relationships of the stereoisomers containing a 7-(3-amino-2-methyl-1-azetidinyl) moiety.
AID205883In vitro minimum inhibitory concentration for Staphylococcus epidermidis ATCC 155-11994Journal of medicinal chemistry, Nov-25, Volume: 37, Issue:24
7-azetidinylquinolones as antibacterial agents. 2. Synthesis and biological activity of 7-(2,3-disubstituted-1-azetidinyl)-4-oxoquinoline- and -1,8-naphthyridine-3-carboxylic acids. Properties and structure-activity relationships of quinolones with an aze
AID21978Solubility (buffer pH 7.4)1994Journal of medicinal chemistry, Nov-25, Volume: 37, Issue:24
7-azetidinylquinolones as antibacterial agents. 2. Synthesis and biological activity of 7-(2,3-disubstituted-1-azetidinyl)-4-oxoquinoline- and -1,8-naphthyridine-3-carboxylic acids. Properties and structure-activity relationships of quinolones with an aze
AID125265In vitro antibacterial activity measured as minimum inhibitory concentration was evaluated on morganella morganii ATCC 8019 (Mm).1995Journal of medicinal chemistry, Mar-31, Volume: 38, Issue:7
7-Azetidinylquinolones as antibacterial agents. 3. Synthesis, properties and structure-activity relationships of the stereoisomers containing a 7-(3-amino-2-methyl-1-azetidinyl) moiety.
AID206614In vitro antibacterial activity measured as minimum inhibitory concentration was evaluated on Staphylococcus aureus ATCC 25178 (Sa).1995Journal of medicinal chemistry, Mar-31, Volume: 38, Issue:7
7-Azetidinylquinolones as antibacterial agents. 3. Synthesis, properties and structure-activity relationships of the stereoisomers containing a 7-(3-amino-2-methyl-1-azetidinyl) moiety.
AID96426In vitro minimum inhibitory concentration to inhibit Klebsiella pneumoniae ATCC 100311994Journal of medicinal chemistry, Nov-25, Volume: 37, Issue:24
7-azetidinylquinolones as antibacterial agents. 2. Synthesis and biological activity of 7-(2,3-disubstituted-1-azetidinyl)-4-oxoquinoline- and -1,8-naphthyridine-3-carboxylic acids. Properties and structure-activity relationships of quinolones with an aze
AID112204Evaluation of efficacy on systemic infections Pseudomonas aeruginosa HS-116, after oral administration in mice1994Journal of medicinal chemistry, Nov-25, Volume: 37, Issue:24
7-azetidinylquinolones as antibacterial agents. 2. Synthesis and biological activity of 7-(2,3-disubstituted-1-azetidinyl)-4-oxoquinoline- and -1,8-naphthyridine-3-carboxylic acids. Properties and structure-activity relationships of quinolones with an aze
AID68864In vitro minimum inhibitory concentration for Escherichia coli ATCC 107991994Journal of medicinal chemistry, Nov-25, Volume: 37, Issue:24
7-azetidinylquinolones as antibacterial agents. 2. Synthesis and biological activity of 7-(2,3-disubstituted-1-azetidinyl)-4-oxoquinoline- and -1,8-naphthyridine-3-carboxylic acids. Properties and structure-activity relationships of quinolones with an aze
AID113506In vivo efficacy as ED50 against Pseudomonas aeruginosa HS-116 by oral administration in mice.1995Journal of medicinal chemistry, Mar-31, Volume: 38, Issue:7
7-Azetidinylquinolones as antibacterial agents. 3. Synthesis, properties and structure-activity relationships of the stereoisomers containing a 7-(3-amino-2-methyl-1-azetidinyl) moiety.
AID68208In vitro antibacterial activity measured as minimum inhibitory concentration, was evaluated on Enterobacter cloacae ATCC 23355 (Ecl).1995Journal of medicinal chemistry, Mar-31, Volume: 38, Issue:7
7-Azetidinylquinolones as antibacterial agents. 3. Synthesis, properties and structure-activity relationships of the stereoisomers containing a 7-(3-amino-2-methyl-1-azetidinyl) moiety.
AID113378In vivo efficacy as ED50 against Escherichia coli HM-42 by oral administration in mice.1995Journal of medicinal chemistry, Mar-31, Volume: 38, Issue:7
7-Azetidinylquinolones as antibacterial agents. 3. Synthesis, properties and structure-activity relationships of the stereoisomers containing a 7-(3-amino-2-methyl-1-azetidinyl) moiety.
AID23950HPLC capacity factor (k')1994Journal of medicinal chemistry, Nov-25, Volume: 37, Issue:24
7-azetidinylquinolones as antibacterial agents. 2. Synthesis and biological activity of 7-(2,3-disubstituted-1-azetidinyl)-4-oxoquinoline- and -1,8-naphthyridine-3-carboxylic acids. Properties and structure-activity relationships of quinolones with an aze
AID165193In vitro antibacterial activity measured as minimum inhibitory concentration was evaluated on Pseudomonas aeruginosa ATCC 10145 (Pa).1995Journal of medicinal chemistry, Mar-31, Volume: 38, Issue:7
7-Azetidinylquinolones as antibacterial agents. 3. Synthesis, properties and structure-activity relationships of the stereoisomers containing a 7-(3-amino-2-methyl-1-azetidinyl) moiety.
AID10953AUC in mice after oral dose (50 mg/kg)1995Journal of medicinal chemistry, Mar-31, Volume: 38, Issue:7
7-Azetidinylquinolones as antibacterial agents. 3. Synthesis, properties and structure-activity relationships of the stereoisomers containing a 7-(3-amino-2-methyl-1-azetidinyl) moiety.
AID163395In vitro minimum inhibitory concentration for Proteus vulgaris ATCC 84271994Journal of medicinal chemistry, Nov-25, Volume: 37, Issue:24
7-azetidinylquinolones as antibacterial agents. 2. Synthesis and biological activity of 7-(2,3-disubstituted-1-azetidinyl)-4-oxoquinoline- and -1,8-naphthyridine-3-carboxylic acids. Properties and structure-activity relationships of quinolones with an aze
AID10955AUC (0-4 hr) ug/ml/h1994Journal of medicinal chemistry, Nov-25, Volume: 37, Issue:24
7-azetidinylquinolones as antibacterial agents. 2. Synthesis and biological activity of 7-(2,3-disubstituted-1-azetidinyl)-4-oxoquinoline- and -1,8-naphthyridine-3-carboxylic acids. Properties and structure-activity relationships of quinolones with an aze
AID21334Solubility at pH 7.4 buffer.1995Journal of medicinal chemistry, Mar-31, Volume: 38, Issue:7
7-Azetidinylquinolones as antibacterial agents. 3. Synthesis, properties and structure-activity relationships of the stereoisomers containing a 7-(3-amino-2-methyl-1-azetidinyl) moiety.
AID163249In vitro antibacterial activity measured as minimum inhibitory concentration was evaluated on proteus vulgaris ATCC 8427 (Pv).1995Journal of medicinal chemistry, Mar-31, Volume: 38, Issue:7
7-Azetidinylquinolones as antibacterial agents. 3. Synthesis, properties and structure-activity relationships of the stereoisomers containing a 7-(3-amino-2-methyl-1-azetidinyl) moiety.
AID40323In vitro minimum inhibitory concentration for Bacillus cereus ATCC 117781994Journal of medicinal chemistry, Nov-25, Volume: 37, Issue:24
7-azetidinylquinolones as antibacterial agents. 2. Synthesis and biological activity of 7-(2,3-disubstituted-1-azetidinyl)-4-oxoquinoline- and -1,8-naphthyridine-3-carboxylic acids. Properties and structure-activity relationships of quinolones with an aze
AID40320In vitro antibacterial activity measured as minimum inhibitory concentration was evaluated on Bacillus cereus ATCC 11778 (Bc).1995Journal of medicinal chemistry, Mar-31, Volume: 38, Issue:7
7-Azetidinylquinolones as antibacterial agents. 3. Synthesis, properties and structure-activity relationships of the stereoisomers containing a 7-(3-amino-2-methyl-1-azetidinyl) moiety.
AID112203Evaluation of efficacy on systemic infections Escherichia coli HM-42, after oral administration in mice1994Journal of medicinal chemistry, Nov-25, Volume: 37, Issue:24
7-azetidinylquinolones as antibacterial agents. 2. Synthesis and biological activity of 7-(2,3-disubstituted-1-azetidinyl)-4-oxoquinoline- and -1,8-naphthyridine-3-carboxylic acids. Properties and structure-activity relationships of quinolones with an aze
AID68371In vitro minimum inhibitory concentration for Enterobacter cloacae ATCC 233551994Journal of medicinal chemistry, Nov-25, Volume: 37, Issue:24
7-azetidinylquinolones as antibacterial agents. 2. Synthesis and biological activity of 7-(2,3-disubstituted-1-azetidinyl)-4-oxoquinoline- and -1,8-naphthyridine-3-carboxylic acids. Properties and structure-activity relationships of quinolones with an aze
AID26844Dissociation constant (pKa)1994Journal of medicinal chemistry, Nov-25, Volume: 37, Issue:24
7-azetidinylquinolones as antibacterial agents. 2. Synthesis and biological activity of 7-(2,3-disubstituted-1-azetidinyl)-4-oxoquinoline- and -1,8-naphthyridine-3-carboxylic acids. Properties and structure-activity relationships of quinolones with an aze
AID26632Measured ionization constant (pKa)1994Journal of medicinal chemistry, Nov-25, Volume: 37, Issue:24
7-azetidinylquinolones as antibacterial agents. 2. Synthesis and biological activity of 7-(2,3-disubstituted-1-azetidinyl)-4-oxoquinoline- and -1,8-naphthyridine-3-carboxylic acids. Properties and structure-activity relationships of quinolones with an aze
AID113507In vivo efficacy as ED50 against Staphylococcus aureus HS-93 by oral administration in mice.1995Journal of medicinal chemistry, Mar-31, Volume: 38, Issue:7
7-Azetidinylquinolones as antibacterial agents. 3. Synthesis, properties and structure-activity relationships of the stereoisomers containing a 7-(3-amino-2-methyl-1-azetidinyl) moiety.
AID40781In vitro antibacterial activity measured as minimum inhibitory concentration was evaluated on Bacillus subtilis ATCC 6633(Bs).1995Journal of medicinal chemistry, Mar-31, Volume: 38, Issue:7
7-Azetidinylquinolones as antibacterial agents. 3. Synthesis, properties and structure-activity relationships of the stereoisomers containing a 7-(3-amino-2-methyl-1-azetidinyl) moiety.
AID112205Evaluation of efficacy on systemic infections Staphylococcus aureus HS-93, after oral administration in mice1994Journal of medicinal chemistry, Nov-25, Volume: 37, Issue:24
7-azetidinylquinolones as antibacterial agents. 2. Synthesis and biological activity of 7-(2,3-disubstituted-1-azetidinyl)-4-oxoquinoline- and -1,8-naphthyridine-3-carboxylic acids. Properties and structure-activity relationships of quinolones with an aze
AID162785In vitro minimum inhibitory concentration for Pseudomonas aeruginosa ATCC 101451994Journal of medicinal chemistry, Nov-25, Volume: 37, Issue:24
7-azetidinylquinolones as antibacterial agents. 2. Synthesis and biological activity of 7-(2,3-disubstituted-1-azetidinyl)-4-oxoquinoline- and -1,8-naphthyridine-3-carboxylic acids. Properties and structure-activity relationships of quinolones with an aze
AID207363In vitro minimum inhibitory concentration for Staphylococcus aureus ATCC 251781994Journal of medicinal chemistry, Nov-25, Volume: 37, Issue:24
7-azetidinylquinolones as antibacterial agents. 2. Synthesis and biological activity of 7-(2,3-disubstituted-1-azetidinyl)-4-oxoquinoline- and -1,8-naphthyridine-3-carboxylic acids. Properties and structure-activity relationships of quinolones with an aze
AID71098In vitro antibacterial activity measured as minimum inhibitory concentration, was evaluated on Escherichia coli ATCC 23559(Ec).1995Journal of medicinal chemistry, Mar-31, Volume: 38, Issue:7
7-Azetidinylquinolones as antibacterial agents. 3. Synthesis, properties and structure-activity relationships of the stereoisomers containing a 7-(3-amino-2-methyl-1-azetidinyl) moiety.
AID125408In vitro minimum inhibitory concentration for Morganella morganii ATCC 80191994Journal of medicinal chemistry, Nov-25, Volume: 37, Issue:24
7-azetidinylquinolones as antibacterial agents. 2. Synthesis and biological activity of 7-(2,3-disubstituted-1-azetidinyl)-4-oxoquinoline- and -1,8-naphthyridine-3-carboxylic acids. Properties and structure-activity relationships of quinolones with an aze
AID209238In vitro minimum inhibitory concentration for Streptococcus faecalis ATCC 105411994Journal of medicinal chemistry, Nov-25, Volume: 37, Issue:24
7-azetidinylquinolones as antibacterial agents. 2. Synthesis and biological activity of 7-(2,3-disubstituted-1-azetidinyl)-4-oxoquinoline- and -1,8-naphthyridine-3-carboxylic acids. Properties and structure-activity relationships of quinolones with an aze
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's6 (100.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 21.58

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index21.58 (24.57)
Research Supply Index1.95 (2.92)
Research Growth Index4.45 (4.65)
Search Engine Demand Index15.26 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (21.58)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]