Assay ID | Title | Year | Journal | Article |
AID205747 | In vitro antibacterial activity measured as minimum inhibitory concentration was evaluated on Staphylococcus epidermidis ATCC 155-1 (Se). | 1995 | Journal of medicinal chemistry, Mar-31, Volume: 38, Issue:7
| 7-Azetidinylquinolones as antibacterial agents. 3. Synthesis, properties and structure-activity relationships of the stereoisomers containing a 7-(3-amino-2-methyl-1-azetidinyl) moiety. |
AID40785 | In vitro minimum inhibitory concentration for Bacillus subtilis ATCC 6633 | 1994 | Journal of medicinal chemistry, Nov-25, Volume: 37, Issue:24
| 7-azetidinylquinolones as antibacterial agents. 2. Synthesis and biological activity of 7-(2,3-disubstituted-1-azetidinyl)-4-oxoquinoline- and -1,8-naphthyridine-3-carboxylic acids. Properties and structure-activity relationships of quinolones with an aze |
AID21530 | Solubility in water was determined at 25 degrees Centigrade | 1995 | Journal of medicinal chemistry, Mar-31, Volume: 38, Issue:7
| 7-Azetidinylquinolones as antibacterial agents. 3. Synthesis, properties and structure-activity relationships of the stereoisomers containing a 7-(3-amino-2-methyl-1-azetidinyl) moiety. |
AID95535 | In vitro antibacterial activity measured as minimum inhibitory concentration was evaluated on klebsiella pneumoniae ATCC 10031 (Kp). | 1995 | Journal of medicinal chemistry, Mar-31, Volume: 38, Issue:7
| 7-Azetidinylquinolones as antibacterial agents. 3. Synthesis, properties and structure-activity relationships of the stereoisomers containing a 7-(3-amino-2-methyl-1-azetidinyl) moiety. |
AID209229 | In vitro antibacterial activity measured as minimum inhibitory concentration was evaluated on Streptococcus faecalis ATCC 10541 (Sf). | 1995 | Journal of medicinal chemistry, Mar-31, Volume: 38, Issue:7
| 7-Azetidinylquinolones as antibacterial agents. 3. Synthesis, properties and structure-activity relationships of the stereoisomers containing a 7-(3-amino-2-methyl-1-azetidinyl) moiety. |
AID205883 | In vitro minimum inhibitory concentration for Staphylococcus epidermidis ATCC 155-1 | 1994 | Journal of medicinal chemistry, Nov-25, Volume: 37, Issue:24
| 7-azetidinylquinolones as antibacterial agents. 2. Synthesis and biological activity of 7-(2,3-disubstituted-1-azetidinyl)-4-oxoquinoline- and -1,8-naphthyridine-3-carboxylic acids. Properties and structure-activity relationships of quinolones with an aze |
AID21978 | Solubility (buffer pH 7.4) | 1994 | Journal of medicinal chemistry, Nov-25, Volume: 37, Issue:24
| 7-azetidinylquinolones as antibacterial agents. 2. Synthesis and biological activity of 7-(2,3-disubstituted-1-azetidinyl)-4-oxoquinoline- and -1,8-naphthyridine-3-carboxylic acids. Properties and structure-activity relationships of quinolones with an aze |
AID125265 | In vitro antibacterial activity measured as minimum inhibitory concentration was evaluated on morganella morganii ATCC 8019 (Mm). | 1995 | Journal of medicinal chemistry, Mar-31, Volume: 38, Issue:7
| 7-Azetidinylquinolones as antibacterial agents. 3. Synthesis, properties and structure-activity relationships of the stereoisomers containing a 7-(3-amino-2-methyl-1-azetidinyl) moiety. |
AID206614 | In vitro antibacterial activity measured as minimum inhibitory concentration was evaluated on Staphylococcus aureus ATCC 25178 (Sa). | 1995 | Journal of medicinal chemistry, Mar-31, Volume: 38, Issue:7
| 7-Azetidinylquinolones as antibacterial agents. 3. Synthesis, properties and structure-activity relationships of the stereoisomers containing a 7-(3-amino-2-methyl-1-azetidinyl) moiety. |
AID96426 | In vitro minimum inhibitory concentration to inhibit Klebsiella pneumoniae ATCC 10031 | 1994 | Journal of medicinal chemistry, Nov-25, Volume: 37, Issue:24
| 7-azetidinylquinolones as antibacterial agents. 2. Synthesis and biological activity of 7-(2,3-disubstituted-1-azetidinyl)-4-oxoquinoline- and -1,8-naphthyridine-3-carboxylic acids. Properties and structure-activity relationships of quinolones with an aze |
AID112204 | Evaluation of efficacy on systemic infections Pseudomonas aeruginosa HS-116, after oral administration in mice | 1994 | Journal of medicinal chemistry, Nov-25, Volume: 37, Issue:24
| 7-azetidinylquinolones as antibacterial agents. 2. Synthesis and biological activity of 7-(2,3-disubstituted-1-azetidinyl)-4-oxoquinoline- and -1,8-naphthyridine-3-carboxylic acids. Properties and structure-activity relationships of quinolones with an aze |
AID68864 | In vitro minimum inhibitory concentration for Escherichia coli ATCC 10799 | 1994 | Journal of medicinal chemistry, Nov-25, Volume: 37, Issue:24
| 7-azetidinylquinolones as antibacterial agents. 2. Synthesis and biological activity of 7-(2,3-disubstituted-1-azetidinyl)-4-oxoquinoline- and -1,8-naphthyridine-3-carboxylic acids. Properties and structure-activity relationships of quinolones with an aze |
AID113506 | In vivo efficacy as ED50 against Pseudomonas aeruginosa HS-116 by oral administration in mice. | 1995 | Journal of medicinal chemistry, Mar-31, Volume: 38, Issue:7
| 7-Azetidinylquinolones as antibacterial agents. 3. Synthesis, properties and structure-activity relationships of the stereoisomers containing a 7-(3-amino-2-methyl-1-azetidinyl) moiety. |
AID68208 | In vitro antibacterial activity measured as minimum inhibitory concentration, was evaluated on Enterobacter cloacae ATCC 23355 (Ecl). | 1995 | Journal of medicinal chemistry, Mar-31, Volume: 38, Issue:7
| 7-Azetidinylquinolones as antibacterial agents. 3. Synthesis, properties and structure-activity relationships of the stereoisomers containing a 7-(3-amino-2-methyl-1-azetidinyl) moiety. |
AID113378 | In vivo efficacy as ED50 against Escherichia coli HM-42 by oral administration in mice. | 1995 | Journal of medicinal chemistry, Mar-31, Volume: 38, Issue:7
| 7-Azetidinylquinolones as antibacterial agents. 3. Synthesis, properties and structure-activity relationships of the stereoisomers containing a 7-(3-amino-2-methyl-1-azetidinyl) moiety. |
AID23950 | HPLC capacity factor (k') | 1994 | Journal of medicinal chemistry, Nov-25, Volume: 37, Issue:24
| 7-azetidinylquinolones as antibacterial agents. 2. Synthesis and biological activity of 7-(2,3-disubstituted-1-azetidinyl)-4-oxoquinoline- and -1,8-naphthyridine-3-carboxylic acids. Properties and structure-activity relationships of quinolones with an aze |
AID165193 | In vitro antibacterial activity measured as minimum inhibitory concentration was evaluated on Pseudomonas aeruginosa ATCC 10145 (Pa). | 1995 | Journal of medicinal chemistry, Mar-31, Volume: 38, Issue:7
| 7-Azetidinylquinolones as antibacterial agents. 3. Synthesis, properties and structure-activity relationships of the stereoisomers containing a 7-(3-amino-2-methyl-1-azetidinyl) moiety. |
AID10953 | AUC in mice after oral dose (50 mg/kg) | 1995 | Journal of medicinal chemistry, Mar-31, Volume: 38, Issue:7
| 7-Azetidinylquinolones as antibacterial agents. 3. Synthesis, properties and structure-activity relationships of the stereoisomers containing a 7-(3-amino-2-methyl-1-azetidinyl) moiety. |
AID163395 | In vitro minimum inhibitory concentration for Proteus vulgaris ATCC 8427 | 1994 | Journal of medicinal chemistry, Nov-25, Volume: 37, Issue:24
| 7-azetidinylquinolones as antibacterial agents. 2. Synthesis and biological activity of 7-(2,3-disubstituted-1-azetidinyl)-4-oxoquinoline- and -1,8-naphthyridine-3-carboxylic acids. Properties and structure-activity relationships of quinolones with an aze |
AID10955 | AUC (0-4 hr) ug/ml/h | 1994 | Journal of medicinal chemistry, Nov-25, Volume: 37, Issue:24
| 7-azetidinylquinolones as antibacterial agents. 2. Synthesis and biological activity of 7-(2,3-disubstituted-1-azetidinyl)-4-oxoquinoline- and -1,8-naphthyridine-3-carboxylic acids. Properties and structure-activity relationships of quinolones with an aze |
AID21334 | Solubility at pH 7.4 buffer. | 1995 | Journal of medicinal chemistry, Mar-31, Volume: 38, Issue:7
| 7-Azetidinylquinolones as antibacterial agents. 3. Synthesis, properties and structure-activity relationships of the stereoisomers containing a 7-(3-amino-2-methyl-1-azetidinyl) moiety. |
AID163249 | In vitro antibacterial activity measured as minimum inhibitory concentration was evaluated on proteus vulgaris ATCC 8427 (Pv). | 1995 | Journal of medicinal chemistry, Mar-31, Volume: 38, Issue:7
| 7-Azetidinylquinolones as antibacterial agents. 3. Synthesis, properties and structure-activity relationships of the stereoisomers containing a 7-(3-amino-2-methyl-1-azetidinyl) moiety. |
AID40323 | In vitro minimum inhibitory concentration for Bacillus cereus ATCC 11778 | 1994 | Journal of medicinal chemistry, Nov-25, Volume: 37, Issue:24
| 7-azetidinylquinolones as antibacterial agents. 2. Synthesis and biological activity of 7-(2,3-disubstituted-1-azetidinyl)-4-oxoquinoline- and -1,8-naphthyridine-3-carboxylic acids. Properties and structure-activity relationships of quinolones with an aze |
AID40320 | In vitro antibacterial activity measured as minimum inhibitory concentration was evaluated on Bacillus cereus ATCC 11778 (Bc). | 1995 | Journal of medicinal chemistry, Mar-31, Volume: 38, Issue:7
| 7-Azetidinylquinolones as antibacterial agents. 3. Synthesis, properties and structure-activity relationships of the stereoisomers containing a 7-(3-amino-2-methyl-1-azetidinyl) moiety. |
AID112203 | Evaluation of efficacy on systemic infections Escherichia coli HM-42, after oral administration in mice | 1994 | Journal of medicinal chemistry, Nov-25, Volume: 37, Issue:24
| 7-azetidinylquinolones as antibacterial agents. 2. Synthesis and biological activity of 7-(2,3-disubstituted-1-azetidinyl)-4-oxoquinoline- and -1,8-naphthyridine-3-carboxylic acids. Properties and structure-activity relationships of quinolones with an aze |
AID68371 | In vitro minimum inhibitory concentration for Enterobacter cloacae ATCC 23355 | 1994 | Journal of medicinal chemistry, Nov-25, Volume: 37, Issue:24
| 7-azetidinylquinolones as antibacterial agents. 2. Synthesis and biological activity of 7-(2,3-disubstituted-1-azetidinyl)-4-oxoquinoline- and -1,8-naphthyridine-3-carboxylic acids. Properties and structure-activity relationships of quinolones with an aze |
AID26844 | Dissociation constant (pKa) | 1994 | Journal of medicinal chemistry, Nov-25, Volume: 37, Issue:24
| 7-azetidinylquinolones as antibacterial agents. 2. Synthesis and biological activity of 7-(2,3-disubstituted-1-azetidinyl)-4-oxoquinoline- and -1,8-naphthyridine-3-carboxylic acids. Properties and structure-activity relationships of quinolones with an aze |
AID26632 | Measured ionization constant (pKa) | 1994 | Journal of medicinal chemistry, Nov-25, Volume: 37, Issue:24
| 7-azetidinylquinolones as antibacterial agents. 2. Synthesis and biological activity of 7-(2,3-disubstituted-1-azetidinyl)-4-oxoquinoline- and -1,8-naphthyridine-3-carboxylic acids. Properties and structure-activity relationships of quinolones with an aze |
AID113507 | In vivo efficacy as ED50 against Staphylococcus aureus HS-93 by oral administration in mice. | 1995 | Journal of medicinal chemistry, Mar-31, Volume: 38, Issue:7
| 7-Azetidinylquinolones as antibacterial agents. 3. Synthesis, properties and structure-activity relationships of the stereoisomers containing a 7-(3-amino-2-methyl-1-azetidinyl) moiety. |
AID40781 | In vitro antibacterial activity measured as minimum inhibitory concentration was evaluated on Bacillus subtilis ATCC 6633(Bs). | 1995 | Journal of medicinal chemistry, Mar-31, Volume: 38, Issue:7
| 7-Azetidinylquinolones as antibacterial agents. 3. Synthesis, properties and structure-activity relationships of the stereoisomers containing a 7-(3-amino-2-methyl-1-azetidinyl) moiety. |
AID112205 | Evaluation of efficacy on systemic infections Staphylococcus aureus HS-93, after oral administration in mice | 1994 | Journal of medicinal chemistry, Nov-25, Volume: 37, Issue:24
| 7-azetidinylquinolones as antibacterial agents. 2. Synthesis and biological activity of 7-(2,3-disubstituted-1-azetidinyl)-4-oxoquinoline- and -1,8-naphthyridine-3-carboxylic acids. Properties and structure-activity relationships of quinolones with an aze |
AID162785 | In vitro minimum inhibitory concentration for Pseudomonas aeruginosa ATCC 10145 | 1994 | Journal of medicinal chemistry, Nov-25, Volume: 37, Issue:24
| 7-azetidinylquinolones as antibacterial agents. 2. Synthesis and biological activity of 7-(2,3-disubstituted-1-azetidinyl)-4-oxoquinoline- and -1,8-naphthyridine-3-carboxylic acids. Properties and structure-activity relationships of quinolones with an aze |
AID207363 | In vitro minimum inhibitory concentration for Staphylococcus aureus ATCC 25178 | 1994 | Journal of medicinal chemistry, Nov-25, Volume: 37, Issue:24
| 7-azetidinylquinolones as antibacterial agents. 2. Synthesis and biological activity of 7-(2,3-disubstituted-1-azetidinyl)-4-oxoquinoline- and -1,8-naphthyridine-3-carboxylic acids. Properties and structure-activity relationships of quinolones with an aze |
AID71098 | In vitro antibacterial activity measured as minimum inhibitory concentration, was evaluated on Escherichia coli ATCC 23559(Ec). | 1995 | Journal of medicinal chemistry, Mar-31, Volume: 38, Issue:7
| 7-Azetidinylquinolones as antibacterial agents. 3. Synthesis, properties and structure-activity relationships of the stereoisomers containing a 7-(3-amino-2-methyl-1-azetidinyl) moiety. |
AID125408 | In vitro minimum inhibitory concentration for Morganella morganii ATCC 8019 | 1994 | Journal of medicinal chemistry, Nov-25, Volume: 37, Issue:24
| 7-azetidinylquinolones as antibacterial agents. 2. Synthesis and biological activity of 7-(2,3-disubstituted-1-azetidinyl)-4-oxoquinoline- and -1,8-naphthyridine-3-carboxylic acids. Properties and structure-activity relationships of quinolones with an aze |
AID209238 | In vitro minimum inhibitory concentration for Streptococcus faecalis ATCC 10541 | 1994 | Journal of medicinal chemistry, Nov-25, Volume: 37, Issue:24
| 7-azetidinylquinolones as antibacterial agents. 2. Synthesis and biological activity of 7-(2,3-disubstituted-1-azetidinyl)-4-oxoquinoline- and -1,8-naphthyridine-3-carboxylic acids. Properties and structure-activity relationships of quinolones with an aze |
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |