Page last updated: 2024-11-01

nifedipine and Constipation

nifedipine has been researched along with Constipation in 9 studies

Nifedipine: A potent vasodilator agent with calcium antagonistic action. It is a useful anti-anginal agent that also lowers blood pressure.

Constipation: Infrequent or difficult evacuation of FECES. These symptoms are associated with a variety of causes, including low DIETARY FIBER intake, emotional or nervous disturbances, systemic and structural disorders, drug-induced aggravation, and infections.

Research Excerpts

ExcerptRelevanceReference
" Reports on clinical use of bisphosphonates for bone pain in cancer, controlled release opioids, selection of laxatives for opioid-induced constipation and the calcium channel blocker nifedipine as an analgesic are described."8.81Analgesia issues in palliative care: bone pain, controlled release opioids, managing opioid-induced constipation and nifedipine as an analgesic. ( Fine, PG, 2002)
"002; multivariate analysis of variance), with 7 significant univariate treatment effects, all favoring COER-verapamil, being noted-pedal edema, polyuria, rapid heart beat or palpitations, hives, muscle cramps, abdominal cramps, and headaches."5.09Physical Symptoms Distress Index: a sensitive tool to evaluate the impact of pharmacological agents on quality of life. ( Anderson, RB; Hollenberg, NK; Williams, GH, 1999)
"We conclude that constipation as a result of some calcium channel blockers may be caused by inhibition of colonic motor activity by nifedipine and, to a lesser extent, by verapamil."5.08Nifedipine and verapamil inhibit the sigmoid colon myoelectric response to eating in healthy volunteers. ( Annese, V; Bassotti, G; Calcara, C; Fiorella, S; Morelli, A; Roselli, P, 1998)
" Reports on clinical use of bisphosphonates for bone pain in cancer, controlled release opioids, selection of laxatives for opioid-induced constipation and the calcium channel blocker nifedipine as an analgesic are described."4.81Analgesia issues in palliative care: bone pain, controlled release opioids, managing opioid-induced constipation and nifedipine as an analgesic. ( Fine, PG, 2002)
" After treatment with a sustained release formulation of the calcium antagonist, nifedipine, their blood pressure returned to normal, anal tone was reduced, and the frequency and intensity of anal pain was suppressed."3.69Hereditary proctalgia fugax and constipation: report of a second family. ( Celik, AF; Donnelly, TC; Katsinelos, P; Khan, MI; Read, NW, 1995)

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19903 (33.33)18.7374
1990's3 (33.33)18.2507
2000's2 (22.22)29.6817
2010's1 (11.11)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Lin, CY1
Zhang, M1
Huang, T1
Yang, LL1
Fu, HB1
Zhao, L1
Zhong, LL1
Mu, HX1
Shi, XK1
Leung, CF1
Fan, BM1
Jiang, M1
Lu, AP1
Zhu, LX1
Bian, ZX1
Fine, PG1
de la Portilla, F1
Borrero, JJ1
Rafel, E1
Covinsky, JO1
Hamburger, SC1
Lewis, GR1
Celik, AF1
Katsinelos, P1
Read, NW1
Khan, MI1
Donnelly, TC1
Bassotti, G1
Calcara, C1
Annese, V1
Fiorella, S1
Roselli, P1
Morelli, A1
Anderson, RB1
Hollenberg, NK1
Williams, GH1
Berman, BA1
Ross, RN1

Reviews

3 reviews available for nifedipine and Constipation

ArticleYear
Analgesia issues in palliative care: bone pain, controlled release opioids, managing opioid-induced constipation and nifedipine as an analgesic.
    Journal of pain & palliative care pharmacotherapy, 2002, Volume: 16, Issue:1

    Topics: Adult; Analgesics; Analgesics, Opioid; Bone and Bones; Calcium Channel Blockers; Cathartics; Constip

2002
Slow channel blockers.
    Southern medical journal, 1983, Volume: 76, Issue:1

    Topics: Angina Pectoris; Arrhythmias, Cardiac; Calcium Channel Blockers; Chemical Phenomena; Chemistry; Cons

1983
Treating coexisting cardiovascular and pulmonary disease with calcium antagonists.
    Annals of allergy, 1986, Volume: 56, Issue:3

    Topics: Adrenergic beta-Antagonists; Angina Pectoris; Asthma, Exercise-Induced; Bronchial Spasm; Calcium; Ca

1986

Trials

2 trials available for nifedipine and Constipation

ArticleYear
Nifedipine and verapamil inhibit the sigmoid colon myoelectric response to eating in healthy volunteers.
    Diseases of the colon and rectum, 1998, Volume: 41, Issue:3

    Topics: Adult; Calcium Channel Blockers; Colon, Sigmoid; Constipation; Eating; Gastrointestinal Motility; Hu

1998
Physical Symptoms Distress Index: a sensitive tool to evaluate the impact of pharmacological agents on quality of life.
    Archives of internal medicine, 1999, Apr-12, Volume: 159, Issue:7

    Topics: Adult; Aged; Aged, 80 and over; Antihypertensive Agents; Calcium Channel Blockers; Constipation; Dou

1999

Other Studies

4 other studies available for nifedipine and Constipation

ArticleYear
Spexin Enhances Bowel Movement through Activating L-type Voltage-dependent Calcium Channel via Galanin Receptor 2 in Mice.
    Scientific reports, 2015, Jul-10, Volume: 5

    Topics: Animals; Calcium; Calcium Channels, L-Type; Case-Control Studies; Colon; Constipation; Female; Gastr

2015
Hereditary vacuolar internal anal sphincter myopathy causing proctalgia fugax and constipation: a new case contribution.
    European journal of gastroenterology & hepatology, 2005, Volume: 17, Issue:3

    Topics: Aged; Anus Diseases; Calcium Channel Blockers; Constipation; Female; Humans; Hypertrophy; Muscle, Sm

2005
The long-term management of hypertension with verapamil.
    Clinical and experimental pharmacology & physiology. Supplement, 1982, Volume: 6

    Topics: Aged; Blood Pressure; Calcium Channel Blockers; Cardiac Output; Constipation; Female; Heart Rate; Hu

1982
Hereditary proctalgia fugax and constipation: report of a second family.
    Gut, 1995, Volume: 36, Issue:4

    Topics: Adult; Aged; Anal Canal; Constipation; Family; Female; Humans; Hypertension; Hypertrophy; Male; Midd

1995