trimebutine has been researched along with Constipation in 5 studies
Trimebutine: Proposed spasmolytic with possible local anesthetic action used in gastrointestinal disorders.
Constipation: Infrequent or difficult evacuation of FECES. These symptoms are associated with a variety of causes, including low DIETARY FIBER intake, emotional or nervous disturbances, systemic and structural disorders, drug-induced aggravation, and infections.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Supportive treatment with loperamide is associated with constipation." | 9.69 | Efficacy of probiotics and trimebutine maleate for abemaciclib-induced diarrhea: A randomized, open-label phase II trial (MERMAID, WJOG11318B). ( Doi, M; Iwasa, T; Masuda, H; Matsumoto, K; Miyoshi, Y; Niikura, N; Sagara, Y; Sakai, H; Shimomura, A; Takahashi, M; Takano, T; Tanabe, Y; Tokunaga, S; Tsurutani, J; Yoshimura, K, 2023) |
| "To observe the efficacy and adverse drug reaction of trimebutine maleate in treating patients with functional dyspepsia (FD) coexisting with diarrhea dominant irritable bowel syndrome (IBS-D)." | 9.12 | [A randomized and case-control clinical study on trimebutine maleate in treating functional dyspepsia coexisting with diarrhea-dominant irritable bowel syndrome]. ( Guo, JN; Li, HJ; Lin, YH; Yan, R; Zeng, ZY; Zhong, YQ; Zhu, J, 2007) |
| "A double-blind crossover study on the effects of trimebutine on large bowel function was performed in 24 consecutive patients complaining of chronic idiopathic constipation." | 9.07 | Effects of trimebutine on colonic function in patients with chronic idiopathic constipation: evidence for the need of a physiologic rather than clinical selection. ( Devroede, G; Pilote, M; Schang, JC, 1993) |
| "Fenoverine acts as a synchronizer of smooth muscle in modulating the intracellular influx of calcium." | 6.78 | [Efficacy of fenoverine and trimebutine in the management of irritable bowel syndrome: multicenter randomized double-blind non-inferiority clinical study]. ( Baek, IH; Choi, SC; Choung, RS; Jeen, YT; Kang, SH; Kim, KO; Kim, SY; Kim, YS; Koo, JS; Koo, YS; Lee, JH; Lee, SJ; Moon, JS; Park, JJ; Park, SC, 2013) |
| " Supportive treatment with loperamide is associated with constipation." | 5.69 | Efficacy of probiotics and trimebutine maleate for abemaciclib-induced diarrhea: A randomized, open-label phase II trial (MERMAID, WJOG11318B). ( Doi, M; Iwasa, T; Masuda, H; Matsumoto, K; Miyoshi, Y; Niikura, N; Sagara, Y; Sakai, H; Shimomura, A; Takahashi, M; Takano, T; Tanabe, Y; Tokunaga, S; Tsurutani, J; Yoshimura, K, 2023) |
| "To observe the efficacy and adverse drug reaction of trimebutine maleate in treating patients with functional dyspepsia (FD) coexisting with diarrhea dominant irritable bowel syndrome (IBS-D)." | 5.12 | [A randomized and case-control clinical study on trimebutine maleate in treating functional dyspepsia coexisting with diarrhea-dominant irritable bowel syndrome]. ( Guo, JN; Li, HJ; Lin, YH; Yan, R; Zeng, ZY; Zhong, YQ; Zhu, J, 2007) |
| "A double-blind crossover study on the effects of trimebutine on large bowel function was performed in 24 consecutive patients complaining of chronic idiopathic constipation." | 5.07 | Effects of trimebutine on colonic function in patients with chronic idiopathic constipation: evidence for the need of a physiologic rather than clinical selection. ( Devroede, G; Pilote, M; Schang, JC, 1993) |
| "Fenoverine acts as a synchronizer of smooth muscle in modulating the intracellular influx of calcium." | 2.78 | [Efficacy of fenoverine and trimebutine in the management of irritable bowel syndrome: multicenter randomized double-blind non-inferiority clinical study]. ( Baek, IH; Choi, SC; Choung, RS; Jeen, YT; Kang, SH; Kim, KO; Kim, SY; Kim, YS; Koo, JS; Koo, YS; Lee, JH; Lee, SJ; Moon, JS; Park, JJ; Park, SC, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (40.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 1 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Masuda, H | 1 |
| Tanabe, Y | 1 |
| Sakai, H | 1 |
| Matsumoto, K | 1 |
| Shimomura, A | 1 |
| Doi, M | 1 |
| Miyoshi, Y | 1 |
| Takahashi, M | 1 |
| Sagara, Y | 1 |
| Tokunaga, S | 1 |
| Iwasa, T | 1 |
| Niikura, N | 1 |
| Yoshimura, K | 1 |
| Takano, T | 1 |
| Tsurutani, J | 1 |
| Kang, SH | 1 |
| Jeen, YT | 1 |
| Koo, JS | 1 |
| Koo, YS | 1 |
| Kim, KO | 1 |
| Kim, YS | 1 |
| Kim, SY | 1 |
| Moon, JS | 1 |
| Park, JJ | 1 |
| Baek, IH | 1 |
| Park, SC | 1 |
| Lee, SJ | 1 |
| Lee, JH | 1 |
| Choung, RS | 1 |
| Choi, SC | 1 |
| Zhong, YQ | 1 |
| Zhu, J | 1 |
| Guo, JN | 1 |
| Yan, R | 1 |
| Li, HJ | 1 |
| Lin, YH | 1 |
| Zeng, ZY | 1 |
| Schang, JC | 1 |
| Devroede, G | 1 |
| Pilote, M | 1 |
| Fraitag, B | 1 |
| Hostein, J | 1 |
| Pascaud, X | 1 |
| Junien, JL | 1 |
1 review available for trimebutine and Constipation
| Article | Year |
|---|---|
[Trimebutine. Pharmacology, recent concepts about its mechanism of action, therapeutic results].
Topics: Clinical Trials as Topic; Colon; Colonic Diseases, Functional; Constipation; Dyspepsia; Endorphins; | 1992 |
5 trials available for trimebutine and Constipation
| Article | Year |
|---|---|
Efficacy of probiotics and trimebutine maleate for abemaciclib-induced diarrhea: A randomized, open-label phase II trial (MERMAID, WJOG11318B).
Topics: Breast Neoplasms; Constipation; Diarrhea; Female; Humans; Loperamide; Probiotics; Quality of Life; T | 2023 |
[Efficacy of fenoverine and trimebutine in the management of irritable bowel syndrome: multicenter randomized double-blind non-inferiority clinical study].
Topics: Abdominal Pain; Adult; Constipation; Diarrhea; Double-Blind Method; Drug Administration Schedule; Fe | 2013 |
[A randomized and case-control clinical study on trimebutine maleate in treating functional dyspepsia coexisting with diarrhea-dominant irritable bowel syndrome].
Topics: Adolescent; Adult; Case-Control Studies; Constipation; Diarrhea; Dyspepsia; Female; Gastrointestinal | 2007 |
Effects of trimebutine on colonic function in patients with chronic idiopathic constipation: evidence for the need of a physiologic rather than clinical selection.
Topics: Action Potentials; Adolescent; Adult; Aged; Chronic Disease; Colon; Constipation; Defecation; Double | 1993 |
[Trimebutine. Pharmacology, recent concepts about its mechanism of action, therapeutic results].
Topics: Clinical Trials as Topic; Colon; Colonic Diseases, Functional; Constipation; Dyspepsia; Endorphins; | 1992 |