Page last updated: 2024-12-06

brl 46470

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

BRL 46470: a 5-HT3 receptor antagonist and anxiolytic compound; BRL 46470A is the hydrochloride salt [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID71785
CHEMBL ID2105377
SCHEMBL ID634826
SCHEMBL ID20362251
SCHEMBL ID21715163
MeSH IDM0203867

Synonyms (24)

Synonym
brl 46470
gtpl2302
brl-46470
3,3-dimethyl-n-[(1r,5s)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl]-2h-indole-1-carboxamide
117086-68-7
CHEMBL2105377
r92jb88o88 ,
3,3-dimethyl-n-1alphah,5alphah-tropan-3alpha-yl-1-indolinecarboxamide
endo-n-(8-methyl-8-azabicyclo(3.2.1)oct-3-yl)-2,3-dihydro-3,3-dimethylindole-1-carboxamide
ricasetron [inn:ban]
unii-r92jb88o88
1h-indole-1-carboxamide, 2,3-dihydro-3,3-dimethyl-n-(8-methyl-8-azabicyclo(3.2.1)oct-3-yl)-, endo-
ricasetron [inn]
SCHEMBL634826
3,3-dimethyl-n-(8-methyl-8-azabicyclo[3.2.1]octan-3-yl)-2h-indole-1-carboxamide
3,3-dimethyl-n-[(1s,5r)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl]-2h-indole-1-carboxamide
SCHEMBL20362251
Q7322878
R-150
3,3-dimethyl-n-[(1r,5s)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl]-2h-indole-1-carboxamide.
3,3-dimethyl-n-((1r,3r,5s)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl)indoline-1-carboxamide
SCHEMBL21715163
DTXSID501028553
AKOS040749297

Research Excerpts

Dosage Studied

ExcerptRelevanceReference
" This anti-emetic activity occurred with oral or intravenously-administered BRL 46470 even when dosed 3-4 h before radiation."( Prolonged anti-emetic activity and 5-HT3-receptor antagonism by BRL 46470 in conscious ferrets.
Bermudez, J; Sanger, GJ, 1994
)
0.76
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (20)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's20 (100.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 11.31

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index11.31 (24.57)
Research Supply Index3.14 (2.92)
Research Growth Index4.45 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (11.31)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials2 (10.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other18 (90.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]