Page last updated: 2024-11-02

oxybutynin and Constipation

oxybutynin has been researched along with Constipation in 15 studies

oxybutynin: RN given refers to parent cpd
oxybutynin : A racemate comprising equimolar amounts of (R)-oxybutynin and esoxybutynin. An antispasmodic used for the treatment of overactive bladder.

Constipation: Infrequent or difficult evacuation of FECES. These symptoms are associated with a variety of causes, including low DIETARY FIBER intake, emotional or nervous disturbances, systemic and structural disorders, drug-induced aggravation, and infections.

Research Excerpts

ExcerptRelevanceReference
"The findings indicate comparability of transdermal buprenorphine and transdermal fentanyl for pain measures with significantly fewer adverse events (nausea and treatment discontinuation due to adverse events) caused by transdermal buprenorphine."8.88Systematic review of efficacy and safety of buprenorphine versus fentanyl or morphine in patients with chronic moderate to severe pain. ( Aune, D; Hernandez, AV; Kleijnen, J; Misso, K; Riemsma, R; Truyers, C; Wolff, RF, 2012)
"Combination therapy (CT) (desmopressin plus oxybutynin) has been considered for the treatment of monosymptomatic nocturnal enuresis (MNE)."8.31Combination therapy (desmopressin plus oxybutynin) improves the response rate compared with desmopressin alone in patients with monosymptomatic nocturnal enuresis and nocturnal polyuria and absence of constipation predict the response to this treatment. ( Capalbo, D; Di Sessa, A; Esposito, C; Grella, C; Guarino, S; Marzuillo, P; Miraglia Del Giudice, E; Papparella, A, 2023)
" Compared with other opioids, low-dose fentanyl has been suggested to produce milder side effects such as nausea, constipation, and somnolence."7.77[Direct low-dose fentanyl patch (2.1mg) introduction for opioid naïve outpatients with cancer pain]. ( Fujita, S; Fukae, M; Hata, A; Iwamori, S; Kaji, R; Katakami, N; Masuda, Y; Mifune, Y; Nanjo, S; Orita, H; Otsuka, K; Yamatani, T, 2011)
" Extended-release formulations of oxybutynin at 10 mg/d or tolterodine at 4 mg/d were given for 12 weeks to women with 21 to 60 urge urinary incontinence (UUI) episodes per week and an average of 10 or more voids per 24 hours."5.10Prospective, randomized, double-blind study of the efficacy and tolerability of the extended-release formulations of oxybutynin and tolterodine for overactive bladder: results of the OPERA trial. ( Appell, RA; Diokno, AC; Dmochowski, RR; Gburek, BM; Kell, SH; Klimberg, IW; Sand, PK, 2003)
"The findings indicate comparability of transdermal buprenorphine and transdermal fentanyl for pain measures with significantly fewer adverse events (nausea and treatment discontinuation due to adverse events) caused by transdermal buprenorphine."4.88Systematic review of efficacy and safety of buprenorphine versus fentanyl or morphine in patients with chronic moderate to severe pain. ( Aune, D; Hernandez, AV; Kleijnen, J; Misso, K; Riemsma, R; Truyers, C; Wolff, RF, 2012)
"Combination therapy (CT) (desmopressin plus oxybutynin) has been considered for the treatment of monosymptomatic nocturnal enuresis (MNE)."4.31Combination therapy (desmopressin plus oxybutynin) improves the response rate compared with desmopressin alone in patients with monosymptomatic nocturnal enuresis and nocturnal polyuria and absence of constipation predict the response to this treatment. ( Capalbo, D; Di Sessa, A; Esposito, C; Grella, C; Guarino, S; Marzuillo, P; Miraglia Del Giudice, E; Papparella, A, 2023)
" Compared with other opioids, low-dose fentanyl has been suggested to produce milder side effects such as nausea, constipation, and somnolence."3.77[Direct low-dose fentanyl patch (2.1mg) introduction for opioid naïve outpatients with cancer pain]. ( Fujita, S; Fukae, M; Hata, A; Iwamori, S; Kaji, R; Katakami, N; Masuda, Y; Mifune, Y; Nanjo, S; Orita, H; Otsuka, K; Yamatani, T, 2011)
"Oxybutynin was more effective for decreasing voiding frequency."2.80Transcutaneous parasacral electrical stimulation vs oxybutynin for the treatment of overactive bladder in children: a randomized clinical trial. ( Barroso Júnior, U; Bastos Netto, JM; Cunha, C; de Oliveira, LF; Lordelo, P; Moraes, M; Quintiliano, F; Veiga, ML, 2015)
"Daytime wetting is a common problem with various causes that can usually be identified through a careful history, thorough physical examination, and urinalysis."2.43An approach to daytime wetting in children. ( Leung, AK; Robson, WL, 2006)
"All medical records, including the Overactive Bladder Symptom score (OABSS), the modified Indevus Urgency Severity Scale and the International Prostate Symptoms score (IPSS) questionnaires, and uroflowmetry parameters were reviewed at each visit."1.48Treatment Outcome of Overactive Bladder Patients Receiving Antimuscarinic Therapy for More than One Year. ( Hsiao, SM; Kuo, HC; Lin, HH, 2018)

Research

Studies (15)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's8 (53.33)29.6817
2010's6 (40.00)24.3611
2020's1 (6.67)2.80

Authors

AuthorsStudies
Capalbo, D1
Guarino, S1
Di Sessa, A1
Esposito, C1
Grella, C1
Papparella, A1
Miraglia Del Giudice, E1
Marzuillo, P1
Quintiliano, F1
Veiga, ML1
Moraes, M1
Cunha, C1
de Oliveira, LF1
Lordelo, P1
Bastos Netto, JM1
Barroso Júnior, U1
Hsiao, SM1
Lin, HH1
Kuo, HC1
Ellsworth, P1
Caldamone, A1
Saldano, DD1
Chaviano, AH2
Maizels, M2
Listernick, R1
Diokno, AC1
Appell, RA1
Sand, PK2
Dmochowski, RR1
Gburek, BM1
Klimberg, IW1
Kell, SH1
Saltzstein, L1
Robson, WL1
Leung, AK1
Diaz Saldano, D1
Yerkes, EB1
Cheng, EY1
Losavio, J1
Porten, SP1
Sullivan, C1
Zebold, KF1
Hagerty, J1
Kaplan, WE1
López-Pérez, FJ1
Mínguez-Martí, A1
Vicario-Sánchez, E1
Pastor-Clérigues, A1
Sanfeliu-García, J1
Ortega-García, MP1
Hata, A1
Katakami, N1
Masuda, Y1
Nanjo, S1
Otsuka, K1
Kaji, R1
Fujita, S1
Iwamori, S1
Mifune, Y1
Orita, H1
Fukae, M1
Yamatani, T1
Wolff, RF1
Aune, D1
Truyers, C1
Hernandez, AV1
Misso, K1
Riemsma, R1
Kleijnen, J1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Comparison of the Efficacy and Tolerability of DITROPAN XL and DETROL LA in the Treatment of Overactive Bladder[NCT00293839]Phase 3790 participants (Actual)InterventionalCompleted
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

4 reviews available for oxybutynin and Constipation

ArticleYear
Topical oxybutynin (Gelnique) for overactive bladder.
    The Medical letter on drugs and therapeutics, 2010, Feb-08, Volume: 52, Issue:1331

    Topics: Administration, Topical; Animals; Constipation; Humans; Mandelic Acids; Randomized Controlled Trials

2010
Elevating our therapeutic expectations in overactive bladder.
    Journal of the American Academy of Nurse Practitioners, 2004, Volume: 16, Issue:10 Suppl

    Topics: Benzhydryl Compounds; Benzilates; Benzofurans; Constipation; Cresols; Delayed-Action Preparations; H

2004
An approach to daytime wetting in children.
    Advances in pediatrics, 2006, Volume: 53

    Topics: Arousal; Benzhydryl Compounds; Child; Child, Preschool; Constipation; Cresols; Diurnal Enuresis; Hum

2006
Systematic review of efficacy and safety of buprenorphine versus fentanyl or morphine in patients with chronic moderate to severe pain.
    Current medical research and opinion, 2012, Volume: 28, Issue:5

    Topics: Administration, Oral; Analgesics, Opioid; Buprenorphine; Chronic Pain; Constipation; Fentanyl; Human

2012

Trials

2 trials available for oxybutynin and Constipation

ArticleYear
Transcutaneous parasacral electrical stimulation vs oxybutynin for the treatment of overactive bladder in children: a randomized clinical trial.
    The Journal of urology, 2015, Volume: 193, Issue:5 Suppl

    Topics: Child; Comorbidity; Constipation; Female; Humans; Male; Mandelic Acids; Muscarinic Antagonists; Tran

2015
Prospective, randomized, double-blind study of the efficacy and tolerability of the extended-release formulations of oxybutynin and tolterodine for overactive bladder: results of the OPERA trial.
    Mayo Clinic proceedings, 2003, Volume: 78, Issue:6

    Topics: Administration, Oral; Aged; Benzhydryl Compounds; Constipation; Cresols; Delayed-Action Preparations

2003

Other Studies

9 other studies available for oxybutynin and Constipation

ArticleYear
Combination therapy (desmopressin plus oxybutynin) improves the response rate compared with desmopressin alone in patients with monosymptomatic nocturnal enuresis and nocturnal polyuria and absence of constipation predict the response to this treatment.
    European journal of pediatrics, 2023, Volume: 182, Issue:4

    Topics: Child; Constipation; Deamino Arginine Vasopressin; Female; Humans; Male; Nocturnal Enuresis; Polyuri

2023
Treatment Outcome of Overactive Bladder Patients Receiving Antimuscarinic Therapy for More than One Year.
    Lower urinary tract symptoms, 2018, Volume: 10, Issue:1

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Constipation; Female; Humans; Male; Mandelic Acids; Midd

2018
Pediatric voiding dysfunction: a case study.
    Urologic nursing, 2008, Volume: 28, Issue:4

    Topics: Adolescent; Behavior Therapy; Causality; Cholinergic Antagonists; Combined Modality Therapy; Constip

2008
Sustainability of remission of pediatric primary nocturnal enuresis--comparison of remission using Try for Dry vs. non-Try for Dry treatment plans.
    Urologic nursing, 2008, Volume: 28, Issue:4

    Topics: Adolescent; Algorithms; Antidiuretic Agents; Child; Combined Modality Therapy; Constipation; Deamino

2008
A thirteen-year-old girl with anemia.
    Pediatric annals, 2003, Volume: 32, Issue:3

    Topics: Adolescent; Anemia; Chronic Disease; Constipation; Encopresis; Enuresis; Female; Humans; Mandelic Ac

2003
Management of overactive bladder in a difficult-to-treat patient with a transdermal formulation of oxybutynin.
    Urologic nursing, 2005, Volume: 25, Issue:4

    Topics: Administration, Cutaneous; Administration, Oral; Aged, 80 and over; Chemistry, Pharmaceutical; Const

2005
Office management of pediatric primary nocturnal enuresis: a comparison of physician advised and parent chosen alternative treatment outcomes.
    The Journal of urology, 2007, Volume: 178, Issue:4 Pt 2

    Topics: Adolescent; Adult; Antidiuretic Agents; Child; Child, Preschool; Choice Behavior; Combined Modality

2007
[Clinical experience in opioid switch for noncancer chronic pain treatment].
    Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria, 2014, Sep-16, Volume: 38, Issue:5

    Topics: Adjuvants, Pharmaceutic; Administration, Oral; Aged; Aged, 80 and over; Analgesia, Epidural; Analges

2014
[Direct low-dose fentanyl patch (2.1mg) introduction for opioid naïve outpatients with cancer pain].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2011, Volume: 38, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Constipation; Female; Fentanyl; Humans; Male; Mi

2011