papaverine has been researched along with Constipation in 2 studies
Papaverine: An alkaloid found in opium but not closely related to the other opium alkaloids in its structure or pharmacological actions. It is a direct-acting smooth muscle relaxant used in the treatment of impotence and as a vasodilator, especially for cerebral vasodilation. The mechanism of its pharmacological actions is not clear, but it apparently can inhibit phosphodiesterases and it may have direct actions on calcium channels.
papaverine : A benzylisoquinoline alkaloid that is isoquinoline substituted by methoxy groups at positions 6 and 7 and a 3,4-dimethoxybenzyl group at position 1. It has been isolated from Papaver somniferum.
Constipation: Infrequent or difficult evacuation of FECES. These symptoms are associated with a variety of causes, including low DIETARY FIBER intake, emotional or nervous disturbances, systemic and structural disorders, drug-induced aggravation, and infections.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Oral papaverine has been shown to be capable of antagonizing the constipation induced by a single dose of oral morphine." | 3.74 | Counteracting effect of papaverine on morphine inhibition of gastrointestinal transit in mice. ( Palmery, M; Piccolotti, P; Pimpinella, G; Romanelli, L; Tucci, P; Valeri, P, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (50.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Tucci, P | 1 |
| Palmery, M | 1 |
| Piccolotti, P | 1 |
| Pimpinella, G | 1 |
| Valeri, P | 1 |
| Romanelli, L | 1 |
| Kocián, J | 1 |
| Kociánová, J | 1 |
1 trial available for papaverine and Constipation
| Article | Year |
|---|---|
[Clinical experiences with preparation Hylakombun in gastroenterology].
Topics: Adult; Aged; Clinical Trials as Topic; Constipation; Diarrhea; Drug Combinations; Drug Evaluation; D | 1975 |
1 other study available for papaverine and Constipation
| Article | Year |
|---|---|
Counteracting effect of papaverine on morphine inhibition of gastrointestinal transit in mice.
Topics: Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Capsaicin; Constipation; Dexam | 2008 |