ketorolac has been researched along with Constipation in 4 studies
Ketorolac: A pyrrolizine carboxylic acid derivative structurally related to INDOMETHACIN. It is an NSAID and is used principally for its analgesic activity. (From Martindale The Extra Pharmacopoeia, 31st ed)
ketorolac : A racemate comprising equimolar amounts of (R)-(+)- and (S)-(-)-5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid. While only the (S)-(-) enantiomer is a COX1 and COX2 inhibitor, the (R)-(+) enantiomer exhibits potent analgesic activity. A non-steroidal anti-inflammatory drug, ketorolac is mainly used (generally as the tromethamine salt) for its potent analgesic properties in the short-term management of post-operative pain, and in eye drops to relieve the ocular itching associated with seasonal allergic conjunctivitis. It was withdrawn from the market in many countries in 1993 following association with haemorrhage and renal failure.
5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid : A member of the class of pyrrolizines that is 2,3-dihydro-1H-pyrrolizine which is substituted at positions 1 and 5 by carboxy and benzoyl groups, respectively.
Constipation: Infrequent or difficult evacuation of FECES. These symptoms are associated with a variety of causes, including low DIETARY FIBER intake, emotional or nervous disturbances, systemic and structural disorders, drug-induced aggravation, and infections.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Method We performed a cost-effectiveness analysis of three clinical rules of the CMA, targeting adverse drug events at three levels of severity: A) persistent opioid-induced constipation, B) ketorolac-induced gastrointestinal bleeding and C) drug-induced Torsade de Pointes." | 4.12 | Cost-effectiveness of check of medication appropriateness: methodological approach. ( Bisschops, R; D'hulster, E; Luyten, J; Peetermans, WE; Quintens, C; Verbakel, JY; Willems, R, 2022) |
| "Opioids are often used to manage postoperative pain." | 3.11 | Optimizing pain management following kidney stone surgery: can we avoid narcotics? ( Ahn, J; Cuartas, P; Demasi, M; Feiertag, N; Kim, M; Laudano, M; Loloi, J; Mengotto, A; Segall, M; Stern, J; Watts, K, 2022) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 2 (50.00) | 2.80 |
| Authors | Studies |
|---|---|
| D'hulster, E | 1 |
| Quintens, C | 1 |
| Bisschops, R | 1 |
| Willems, R | 1 |
| Peetermans, WE | 1 |
| Verbakel, JY | 1 |
| Luyten, J | 1 |
| Demasi, M | 1 |
| Segall, M | 1 |
| Mengotto, A | 1 |
| Cuartas, P | 1 |
| Feiertag, N | 1 |
| Loloi, J | 1 |
| Ahn, J | 1 |
| Kim, M | 1 |
| Laudano, M | 1 |
| Stern, J | 1 |
| Watts, K | 1 |
| Young, KM | 1 |
1 trial available for ketorolac and Constipation
| Article | Year |
|---|---|
Optimizing pain management following kidney stone surgery: can we avoid narcotics?
Topics: Analgesics, Non-Narcotic; Analgesics, Opioid; Constipation; Humans; Ketorolac; Kidney Calculi; Narco | 2022 |
3 other studies available for ketorolac and Constipation
| Article | Year |
|---|---|
Cost-effectiveness of check of medication appropriateness: methodological approach.
Topics: Analgesics, Opioid; Constipation; Cost-Benefit Analysis; Drug-Related Side Effects and Adverse React | 2022 |
Simple rules, complex behavior.
Topics: Adult; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Constipation; Diagnosis, D | 2008 |
Drugs for pain.
Topics: Acetaminophen; Administration, Oral; Amitriptyline; Analgesics; Analgesics, Non-Narcotic; Analgesics | 1998 |