ceruletide and Constipation

Topics: Aorta, Abdominal; Blood Vessel Prosthesis; Ceruletide; Clinical Trials as Topic; Constipation; Gastrointestinal Motility; Humans; Iliac Artery; Neostigmine; Postoperative Complications; Prospective Studies; Random Allocation

The efficacy and tolerability of Ceruletide and Neostigmin were compared in patients with postoperative intestinal atonia after extensive gynecological surgical operations. Patients treated with Ceruletide (n = 30, dosage of Ceruletide 2 ng/kg/min. i.v.) showed earlier defecation than the Neostigmin-group (n = 30, dosage of neostigmin 3 x 0,5 mg/die). The frequency of side effects was comparable in both groups, patients treated with Ceruletide suffered mainly from gastrointestinal symptoms (nausea) whereas patients treated with Neostigmin complained of disorders of circulation. Ceruletide is faster effective than Neostigmin, the tolerability of both drugs is equivalent.

Topics: Blood Pressure; Ceruletide; Clinical Trials as Topic; Constipation; Defecation; Female; Gastrointestinal Motility; Genital Diseases, Female; Humans; Middle Aged; Neostigmine; Postoperative Complications

25 Patients with metastatic non-seminomatous testicular neoplasms were treated by surgery and cytostatic therapy using a combination consisting of Velban, Bleomycin, Cis-Platinum and/or Ifosfamid. In 22 patients this procedure induced a persistant complete remission with a mean observation time of 23 months. 2 patients died because of post-surgical complications after a second-look-lymphadenectomy. They suffered from rapidly progressive tumor disease. One patient died in a septicemia during chemotherapy. Our experience is that morbidity of an effective chemotherapy should not be underestimated. Transient bone marrow suppression, anorexia, alopecia and hyperpigmentation are unavoidable. However, severe vomiting, disturbed electrolyte metabolism, hemorrhagic cystitis, anemia and septicemia can well be managed by respective supportive care. Septicemia, for instance, may be treated with appropriate antibiotics without inducing tubular necrosis. Supportive measures also will avoid severe chronic defects of ear and kidney function.

Topics: Adult; Alopecia; Anemia; Bleomycin; Ceruletide; Cisplatin; Constipation; Cyclophosphamide; Drug Therapy, Combination; Enema; Humans; Ifosfamide; Male; Middle Aged; Testicular Neoplasms; Vinblastine; Vomiting

Topics: Biliary Tract; Ceruletide; Clinical Trials as Topic; Constipation; Gastrointestinal Motility; Humans; Intestinal Obstruction; Megacolon