chlordiazepoxide, clidinium drug combination profile

chlordiazepoxide, clidinium drug combination: for treatment of functional colopathies; Note: Librax is a multimeaning drug name [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

ID Source	ID
PubMed CID	3080646
MeSH ID	M0105448

Synonym
poxidium
epirax
1-azoniabicyclo(2.2.2)octane, 3-((hydroxydiphenylacetyl)oxy)-1-methyl-, bromide, mixt. with 7-chloro-n-methyl-5-phenyl-3h-1,4-benzodiazepin-2-amine 4-oxide
3h-1,4-benzodiazepin-2-amine, 7-chloro-n-methyl-5-phenyl-, 4-oxide, mixt. with 3-((hydroxydiphenylacetyl)oxy)-1-methyl-1-azoniabicyclo(2.2.2)octane bromide
chlordiazepoxide / clidinium bromide
bralix
librax
spasril
chlordiazepoxide - clidinium
8015-20-1
chlordiazepoxide-clidinium combination
chlordiazepoxide hydrochloride, clidinium bromide drug combination
chlordiazepoxide, clidinium drug combination
Q6542719
DTXSID501000995
3-{[hydroxy(diphenyl)acetyl]oxy}-1-methyl-1-azabicyclo[2.2.2]octan-1-ium bromide--7-chloro-2-(methylimino)-5-phenyl-2,3-dihydro-4h-1,4-benzodiazepin-4-ol (1/1/1)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	10 (71.43)	18.7374
1990's	2 (14.29)	18.2507
2000's	1 (7.14)	29.6817
2010's	0 (0.00)	24.3611
2020's	1 (7.14)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	1 (6.25%)	5.53%
Reviews	1 (6.25%)	6.00%
Case Studies	2 (12.50%)	4.05%
Observational	0 (0.00%)	0.25%
Other	12 (75.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Trials	Classes	Roles
quinacrine Quinacrine: An acridine derivative formerly widely used as an antimalarial but superseded by chloroquine in recent years. It has also been used as an anthelmintic and in the treatment of giardiasis and malignant effusions. It is used in cell biological experiments as an inhibitor of phospholipase A2.. quinacrine : A member of the class of acridines that is acridine substituted by a chloro group at position 6, a methoxy group at position 2 and a [5-(diethylamino)pentan-2-yl]nitrilo group at position 9.	1.97	1	0	acridines; aromatic ether; organochlorine compound; tertiary amino compound	antimalarial; EC 1.8.1.12 (trypanothione-disulfide reductase) inhibitor
chlordiazepoxide Chlordiazepoxide: An anxiolytic benzodiazepine derivative with anticonvulsant, sedative, and amnesic properties. It has also been used in the symptomatic treatment of alcohol withdrawal.. chlordiazepoxide : A benzodiazepine that is 3H-1,4-benzodiazepine 4-oxide substituted by a chloro group at position 7, a phenyl group at position 5 and a methylamino group at position 2.	6.45	14	1	benzodiazepine
cimetidine Cimetidine: A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It inhibits GASTRIC ACID secretion, as well as PEPSIN and GASTRIN output.. cimetidine : A member of the class of guanidines that consists of guanidine carrying a methyl substituent at position 1, a cyano group at position 2 and a 2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl group at position 3. It is a H2-receptor antagonist that inhibits the production of acid in stomach.	1.96	1	0	aliphatic sulfide; guanidines; imidazoles; nitrile	adjuvant; analgesic; anti-ulcer drug; H2-receptor antagonist; P450 inhibitor
clidinium clidinium: see also record for clidinium compounds; RN given refers to cpd without isomeric designation. clidinium : The ester resulting from formal condensation of benzilic acid and 3-hydroxy-1-methyl-1-azoniabicyclo[2.2.2]octane. It is used, generally as the bromide, for the symptomatic treatment of peptic ulcer disease and also to help relieve abdominal or stomach spasms or cramps due to colicky abdominal pain, diverticulitis, and irritable bowel syndrome.	1.93	1	0	diarylmethane
doxepin Doxepin: A dibenzoxepin tricyclic compound. It displays a range of pharmacological actions including maintaining adrenergic innervation. Its mechanism of action is not fully understood, but it appears to block reuptake of monoaminergic neurotransmitters into presynaptic terminals. It also possesses anticholinergic activity and modulates antagonism of histamine H(1)- and H(2)-receptors.. doxepin : A dibenzooxepine that is 6,11-dihydrodibenzo[b,e]oxepine substituted by a 3-(dimethylamino)propylidene group at position 11. It is used as an antidepressant drug.	1.96	1	0	dibenzooxepine; tertiary amino compound	antidepressant
mebeverine mebeverine: RN given refers to parent cpd; structure	2.31	1	0	methoxybenzoic acid
trimebutine Trimebutine: Proposed spasmolytic with possible local anesthetic action used in gastrointestinal disorders.	3.34	1	1	trihydroxybenzoic acid
penicillamine Penicillamine: 3-Mercapto-D-valine. The most characteristic degradation product of the penicillin antibiotics. It is used as an antirheumatic and as a chelating agent in Wilson's disease.. penicillamine : An alpha-amino acid having the structure of valine substituted at the beta position with a sulfanyl group.	2.31	1	0	non-proteinogenic alpha-amino acid; penicillamine	antirheumatic drug; chelator; copper chelator; drug allergen
quinuclidines Quinuclidines: A class of organic compounds which contain two rings that share a pair of bridgehead carbon atoms and contains an amine group.	6.45	14	1	quinuclidines; saturated organic heterobicyclic parent
cardiovascular agents Cardiovascular Agents: Agents that affect the rate or intensity of cardiac contraction, blood vessel diameter, or blood volume.	1.93	1	0

Condition	Relationship Strength	Studies	Trials
Colonic Inertia Symptom characterized by the passage of stool once a week or less.	2.31	1	0
Poisoning, Lead [description not available]	2.31	1	0
Emesis [description not available]	2.31	1	0
Colicky Pain [description not available]	2.31	1	0
Acute Disease Disease having a short and relatively severe course.	2.47	2	0
Anemia A reduction in the number of circulating ERYTHROCYTES or in the quantity of HEMOGLOBIN.	2.31	1	0
Constipation Infrequent or difficult evacuation of FECES. These symptoms are associated with a variety of causes, including low DIETARY FIBER intake, emotional or nervous disturbances, systemic and structural disorders, drug-induced aggravation, and infections.	2.31	1	0
Lead Poisoning Poisoning that results from chronic or acute ingestion, injection, inhalation, or skin absorption of LEAD or lead compounds.	2.31	1	0
Vomiting The forcible expulsion of the contents of the STOMACH through the MOUTH.	2.31	1	0
Abdominal Pain Sensation of discomfort, distress, or agony in the abdominal region.	2.31	1	0
Pregnancy The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.	1.93	1	0
Gallstone Disease [description not available]	1.93	1	0
Gastroduodenal Ulcer [description not available]	1.93	1	0
Urinary Calculi Low-density crystals or stones in any part of the URINARY TRACT. Their chemical compositions often include CALCIUM OXALATE, magnesium ammonium phosphate (struvite), CYSTINE, or URIC ACID.	1.93	1	0
Cholelithiasis Presence or formation of GALLSTONES in the BILIARY TRACT, usually in the gallbladder (CHOLECYSTOLITHIASIS) or the common bile duct (CHOLEDOCHOLITHIASIS).	1.93	1	0
Peptic Ulcer Ulcer that occurs in the regions of the GASTROINTESTINAL TRACT which come into contact with GASTRIC JUICE containing PEPSIN and GASTRIC ACID. It occurs when there are defects in the MUCOSA barrier. The common forms of peptic ulcers are associated with HELICOBACTER PYLORI and the consumption of nonsteroidal anti-inflammatory drugs (NSAIDS).	1.93	1	0
Colonic Diseases, Functional Chronic or recurrent colonic disorders without an identifiable structural or biochemical explanation. The widely recognized IRRITABLE BOWEL SYNDROME falls into this category.	4.97	3	1
Recrudescence [description not available]	1.96	1	0
Curling Ulcer Acute stress DUODENAL ULCER, usually observed in patients with extensive third-degree burns.	1.96	1	0
Duodenal Ulcer A PEPTIC ULCER located in the DUODENUM.	1.96	1	0
Adenocarcinoma, Basal Cell [description not available]	1.98	1	0
Cancer of Esophagus [description not available]	1.98	1	0
Esophageal Reflux [description not available]	1.98	1	0
Esophageal Hernia [description not available]	1.98	1	0
Cancer of Stomach [description not available]	1.98	1	0
Adenocarcinoma A malignant epithelial tumor with a glandular organization.	1.98	1	0
Esophageal Diseases Pathological processes in the ESOPHAGUS.	1.98	1	0
Esophageal Neoplasms Tumors or cancer of the ESOPHAGUS.	1.98	1	0
Esophagitis INFLAMMATION, acute or chronic, of the ESOPHAGUS caused by BACTERIA, chemicals, or TRAUMA.	1.98	1	0
Gastroesophageal Reflux Retrograde flow of gastric juice (GASTRIC ACID) and/or duodenal contents (BILE ACIDS; PANCREATIC JUICE) into the distal ESOPHAGUS, commonly due to incompetence of the LOWER ESOPHAGEAL SPHINCTER.	1.98	1	0
Stomach Neoplasms Tumors or cancer of the STOMACH.	1.98	1	0
Anxiety Neuroses [description not available]	2.91	1	0
Behavior Disorders [description not available]	2.91	1	0
Panic Attacks [description not available]	2.91	1	0
Agoraphobia Obsessive, persistent, intense fear of open places.	2.91	1	0
Anxiety Disorders Persistent and disabling ANXIETY.	2.91	1	0
Mental Disorders Psychiatric illness or diseases manifested by breakdowns in the adaptational process expressed primarily as abnormalities of thought, feeling, and behavior producing either distress or impairment of function.	2.91	1	0
Panic Disorder A type of anxiety disorder characterized by unexpected panic attacks that last minutes or, rarely, hours. Panic attacks begin with intense apprehension, fear or terror and, often, a feeling of impending doom. Symptoms experienced during a panic attack include dyspnea or sensations of being smothered; dizziness, loss of balance or faintness; choking sensations; palpitations or accelerated heart rate; shakiness; sweating; nausea or other form of abdominal distress; depersonalization or derealization; paresthesias; hot flashes or chills; chest discomfort or pain; fear of dying and fear of not being in control of oneself or going crazy. Agoraphobia may also develop. Similar to other anxiety disorders, it may be inherited as an autosomal dominant trait.	2.91	1	0
Purpura, Thrombopenic [description not available]	2	1	0
Purpura, Thrombocytopenic Any form of purpura in which the PLATELET COUNT is decreased. Many forms are thought to be caused by immunological mechanisms.	2	1	0
Eosinophilia, Tropical [description not available]	1.97	1	0
Coenuri Infection [description not available]	1.97	1	0
Cysticercosis Infection with CYSTICERCUS, the larval form of the various tapeworms of the genus Taenia (usually T. solium in man). In humans they penetrate the intestinal wall and invade subcutaneous tissue, brain, eye, muscle, heart, liver, lung, and peritoneum. Brain involvement results in NEUROCYSTICERCOSIS.	1.97	1	0
Eosinophilia Abnormal increase of EOSINOPHILS in the blood, tissues or organs.	1.97	1	0

chlordiazepoxide, clidinium drug combination

Description

Cross-References

Synonyms (16)

Research

Studies (14)

Market Indicators

Research Demand Index: 11.17

Study Types