naltrexone has been researched along with Constipation in 160 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (0.63) | 18.7374 |
| 1990's | 3 (1.88) | 18.2507 |
| 2000's | 37 (23.13) | 29.6817 |
| 2010's | 95 (59.38) | 24.3611 |
| 2020's | 24 (15.00) | 2.80 |
| Authors | Studies |
|---|---|
| Israel, RJ; Mehta, N; Slatkin, NE; Stambler, N | 1 |
| Fujita, Y; Hiruta, E; Imai, H; Ito, M; Kamiya, T; Koizuka, S; Kotake, M; Masuno, T; Matsuura, M; Minato, K; Mogi, J; Nishiba, H; Takei, S; Tanaka, H; Yamazaki, S | 1 |
| Israel, RJ; Peacock, WF; Slatkin, NE; Stambler, N | 1 |
| Adachi, N; Hiraoka, M; Ishida, M; Ishiguro, T; Itoga, T; Onishi, H; Sugano, K; Yaguchi, A | 1 |
| Abe, H; Fushimi, K; Inoue, R; Matsui, H; Sumitani, M; Uchida, K; Yasunaga, H | 1 |
| Hashimoto, S; Honda, K; Nakazawa, M; Takata, K | 1 |
| Dewey, WL; Gillespie, JC; Huang, B; Klongkumnuankarn, P; Li, M; Mendez, RE; Selley, DE; Stevens, DL; Zhang, Y | 1 |
| Hasegawa, K; Ishida, M; Mizunuma, N; Onishi, H; Takahashi, T; Uchida, N; Yabuno, A | 1 |
| Imai, S; Kato, S; Kumai, M; Onoda, H; Saito, Y; Sugawara, M; Takekuma, Y; Tsuruga, K | 1 |
| Arai, K; Fujita, Y; Hiruta, E; Imai, H; Kaira, K; Kamiya, T; Masuno, T; Minato, K; Mogi, J; Nishiba, H; Sandoh, M; Takei, S; Tanaka, H; Yamazaki, S | 1 |
| Brenner, D; Israel, RJ; Slatkin, NE; Stambler, N; Webster, LR | 1 |
| DeGrado, JR; Dube, KM; Goodberlet, MZ; Habeeb, EA; Lupi, KE; Tran, LK | 1 |
| Ishizuka, Y; Kanbayashi, Y; Sawa, S; Shimizu, M; Uchida, M; Yabe, K | 1 |
| Brown, B; Price, ST | 1 |
| Muttini, S; Palandri, C; Racagni, M; Umbrello, M; Venco, R | 1 |
| Anjum, A; Brett, SJ; Cross, M; Gordon, AC; O'Callaghan, D; Patel, PB; Warwick, J | 2 |
| Fukumura, K; Ishibashi, T; Kawaguchi, N; Kubota, R; Ogura, E; Tada, Y | 1 |
| Brenner, DM; Liu, JJ; Quinton, SE | 1 |
| Berger, AA; Clay, CJ; Hasoon, J; Jung, JW; Kassem, H; Kaye, AD; Kaye, AM; Kiernan, HC; Monteferrante, N; Patel, A; Urits, I; Viswanath, O | 1 |
| Hashimoto, M; Hikita, E; Nakamura, K; Shirota, M; Yasu, T | 1 |
| Brenner, DM; Coluzzi, PH; Israel, RJ; Slatkin, NE; Stambler, N | 1 |
| Liao, SS; Slatkin, NE; Stambler, N | 1 |
| Ezaki, N; Harasawa, H; Hasegawa, K; Hashizume, J; Ishii, K; Kawauchi, Y; Kodama, Y; Nakamura, T; Ryu, E; Sasaki, H; Shiojiri, K; Yamashita, H | 1 |
| Wirz, S | 1 |
| Arjona Ferreira, JC; Webster, LR; Yamada, T | 1 |
| Boku, N; Katakami, N; Nakata, K; Narabayashi, M; Oda, K; Shinozaki, K; Suzuki, Y; Tauchi, K; Yokota, T | 1 |
| Markham, A | 1 |
| Brower, V | 1 |
| Arjona Ferreira, JC; Hale, M; Reddy, J; Wild, J; Yamada, T | 1 |
| Harper, JR; Israel, RJ; Khan, A; Michna, E; Webster, LR | 1 |
| Arai, M; Boku, N; Harada, T; Katakami, N; Murata, T; Narabayashi, M; Shinozaki, K; Tada, Y; Tsutsumi, M; Yokota, T | 1 |
| Murphy, JA; Sheridan, EA | 1 |
| Kosugi, K; Tanimoto, T; Yagi, Y | 1 |
| Katakami, N; Tada, Y; Yokota, T | 1 |
| Arjona Ferreira, JC; Baba, Y; Morlion, B; Nalamachu, S; Reddy, J; Webster, LR; Yamada, T | 1 |
| Garcia, JM; Shamliyan, TA | 1 |
| Candy, B; Jones, L; Larkin, PJ; Stone, P; Vickerstaff, V | 1 |
| Abdollahi, M; Mozaffari, S; Nikfar, S | 1 |
| Akbarali, HI; Dewey, WL; Komla, E; Obeng, S; Selley, DE; Stevens, DL; Wang, H; Zhang, Y; Zheng, Y | 1 |
| Blackney, KA; Edwards, DA; Kamdar, NV; Liu, CA | 1 |
| Asonuma, S; Emi, Y; Fujii, M; Ikeda, M; Kajiwara, M; Kometani, T; Mori, M; Noda, Y; Ochiai, T; Shikada, Y | 1 |
| Corsetti, M; Pannemans, J | 1 |
| Moss, J | 1 |
| Fukumura, K; Kubota, R; Wajima, T | 1 |
| Fukumura, K; Kubota, R; Ohnishi, S; Wajima, T | 1 |
| Dong, N; Qu, X; Song, X; Teng, S; Wang, D | 1 |
| Correll, CU; DiPetrillo, L; Ehrich, EW; Jiang, Y; Martin, WF; Pathak, S; Silverman, BL; Weiden, PJ | 1 |
| Ahmad, D; Esmadi, M; Hewlett, A | 1 |
| Beeker, A; Berkhof, J; Neefjes, ECW; Rhodius, CA; Ten Oever, D; van den Berg, HP; van der Vliet, HJ; van der Vorst, MJDL; van der Wijngaart, H; Verheul, HMW | 1 |
| Law, PY; Loh, HH; Tao, PL; Wang, Y; Yang, PP; Yeh, TK | 1 |
| Allingham, S; Brown, L; Clark, K; Currow, DC; Phillips, JL | 1 |
| Arjona Ferreira, JC; Hale, M; Wild, J; Yamada, T | 1 |
| Ishikawa, H; Sato, J; Shino, M; Suzuki, T; Tanaka, R | 1 |
| Blair, HA | 1 |
| Mendelsohn, RB; Nelson, KK; Schattner, MA | 1 |
| Clemens, KE; Faust, M; Jaspers, B; Mikus, G | 1 |
| Baker, JN; Laubisch, JE | 1 |
| Brenner, DM; Ford, AC; Schoenfeld, PS | 1 |
| Alexander, S; Dupuis, LL; Lau, E; Mattiussi, A; Rodrigues, A; Wong, C | 1 |
| McCarberg, BH | 1 |
| Fringer, A; Ivanovi, N; Lötscher, C | 1 |
| Wang, CZ; Yuan, CS | 1 |
| Rauck, RL | 1 |
| Stettler, A; Zulian, GB | 1 |
| Müller-Lissner, S | 1 |
| Canal, J; Carranza, O; Centeno, C; Larumbe, A; Palomar, C; Portela, MA; Zuriarrain, Y | 1 |
| Hellwig, TR; Pottebaum, AA | 1 |
| Clark, K; Currow, DC | 1 |
| Clark, K; Currow, DC; Robinson, M; Rowett, D | 1 |
| Chohan, O; Mayer, A; Yeomanson, D | 1 |
| Barrett, AC; Bortey, E; Forbes, WP; Nalamachu, SR; Paterson, C; Pergolizzi, J; Slatkin, NE; Taylor, R; Yu, J | 1 |
| Thompson, CA | 2 |
| Rodriguez, RW | 1 |
| Battista, V; Santucci, G | 1 |
| Baker, JN; Flerlage, JE | 1 |
| Candy, B; Jones, L; Larkin, PJ; Stone, P; Tookman, A; Vickerstaff, V | 1 |
| Barrett, AC; Bull, J; Forbes, WP; Israel, RJ; Paterson, C; Wellman, CV | 1 |
| Backstedt, D; Jones, R; Prommer, E | 1 |
| Kolbow, J; Maritz, MA; Modess, C; Oswald, S; Rey, H; Siegmund, W; Wegner, D; Weitschies, W | 1 |
| Ahmedzai, SH; Boland, JW | 1 |
| Badke, A; Rosielle, DA | 1 |
| Weber, HC | 1 |
| Kolbow, J; Siegmund, W; Weitschies, W | 1 |
| Baqai, A; Diwan, S; Giambrone, GP; Mehta, N; O'Connell, K | 1 |
| Fernández, SN; Fernández-Llamazares, C; González, R; López, J; López-Herce, J; Santiago, MJ; Urbano, J | 1 |
| Bridgeman, MB; Chokhavatia, S; Dixit, D; John, ES | 1 |
| Atkins, JT; Janku, F; Johnson, LK; Karp, DD; Moss, J; Singleton, PA | 1 |
| Ades, S; Ashikaga, T; Ji, Y; Kumar, S; Mori, M | 1 |
| Harper, JR; Israel, RJ; Rauck, R; Slatkin, NE; Stambler, N | 1 |
| Altshuler, D; Merchan, C; Papadopoulos, J | 1 |
| Chamberlain, BH; Cooney, GA; Israel, RJ; Karver, S; Kremer, AB; Slatkin, NE; Stambler, N; Thomas, J; Watt, CK | 1 |
| Berde, C; Nurko, S | 1 |
| Lang, L | 1 |
| del Valle Rivero, ML; Sanz Rubiales, A | 1 |
| Chappell, D; Conzen, P; Rehm, M | 1 |
| Meerpohl, JJ; Timmer, A | 1 |
| Carrillo, F; Johnson, J; Laustsen, G; Smith, C | 1 |
| Belavic, JM | 1 |
| Holzer, P | 3 |
| Cannom, RR; Mason, RJ | 1 |
| Lux, EA | 1 |
| Chappell, D; Conzen, P | 1 |
| Chamberlain, BH; Cross, K; Israel, RJ; Su, C; Thomas, J; Wang, W; Winston, JL | 1 |
| Atayee, R; Diego, L; Helmons, P; von Gunten, CF | 1 |
| Baker, DE | 1 |
| Kyle, G | 1 |
| Earnshaw, SR; Iyer, S; Klok, RM; McDade, C | 1 |
| Kapoor, S | 1 |
| Garnock-Jones, KP; McKeage, K | 1 |
| Leppert, W | 1 |
| Baumrucker, SJ; Licup, N | 1 |
| Berbari, J; Farah, B; Iskedjian, M; Iyer, S; Librach, SL; Wang, M | 1 |
| Brewer, R; Johnson, FK; Morris, D; Sekora, D; Stauffer, J; Wang, C; Webster, LR | 1 |
| Iyer, SS; Manley, AL; Randazzo, BP; Schulman, SL; Tzanis, EL; Wang, W; Zhang, H | 1 |
| Boyd, TA; Rotshteyn, Y; Yuan, CS | 1 |
| Candy, B; Drake, R; Goodman, ML; Jones, L; Tookman, A | 1 |
| Blonsky, ER; Iyer, S; Manley, A; Michna, E; Randazzo, B; Schulman, S; Tzanis, E; Zhang, H | 1 |
| Byfieldt, N; Clark, K; Currow, DC; Dawe, M | 1 |
| Cooney, GA; Israel, RJ; Karver, S; Lipman, AG; Stambler, N | 1 |
| Duerden, M; Manley, A; Michna, E; Randazzo, B; Schulman, S; Tzanis, E; Wang, W; Weil, AJ; Yu, D; Zhang, H | 1 |
| Lee, JM; Mooney, J | 1 |
| Anissian, L; Carpenito, J; Ramakrishna, T; Schwartz, HW; Stambler, N; Vincent, HK; Vincent, K | 1 |
| Israel, RJ; Lynn, R; Slatkin, NE; Su, C; Wang, W | 1 |
| Bath, B; Bilsky, E; Burkart, J; Dallaire, B; Magiera, D; Phelps, M; Sadee, W; Webster, L; Yancey-Wrona, J; Yang, X | 1 |
| Cayley, WE | 1 |
| Cotton, AL; Danga, A; Moss, J; Patel, PB; Sawh, SB; Selvaraj, IP | 1 |
| Gatti, A; Sabato, AF | 1 |
| Heintz, J; Kissling, KT; Mohassel, LR | 1 |
| Clark, K; Currow, DC; Robinson, MK; Rowett, DS | 1 |
| Bloom, A; Gras, B; Lembo, A; Magge, S | 1 |
| Brick, N | 1 |
| Kurz, A; Sessler, DI | 1 |
| Yuan, CS | 1 |
| Baxter, K; Burton, D; Camilleri, M; Foxx-Orenstein, AE; McKinzie, S; Szarka, LA; Thomforde, G; Zinsmeister, AR | 1 |
| Friedman, D; Jahdi, M; Rim, F; Shaiova, L | 1 |
| Thomas, J | 1 |
| Boyce, D; Carr, DB; McNicol, ED; Schumann, R | 1 |
| Traynor, K | 1 |
| Chami, TN; Cheskin, LJ; Jaffe, JH; Johnson, RE | 1 |
| Foss, FJ; Moss, J; O'Connor, M; Osinski, J; Roizen, FM; Yuan, SC | 1 |
| Foss, JF; Karrison, T; Moss, J; O'Connor, M; Osinski, J; Roizen, MF; Yuan, CS | 1 |
| Scholz, M | 1 |
| Foss, JF; Yuan, CS | 1 |
| Dello Buono, FA; Friedman, JD | 1 |
| Pappagallo, M | 1 |
| Foss, JF | 1 |
| Stephenson, J | 1 |
| De Ponti, F | 1 |
| Dixon, R; Simpkins, JW; Smulkowski, M; Tuttle, R | 1 |
51 review(s) available for naltrexone and Constipation
| Article | Year |
|---|---|
First-Dose Efficacy of Methylnaltrexone in Patients with Severe Medical Illness and Opioid-Induced Constipation: A Pooled Analysis.
Topics: Aged; Analgesics, Opioid; Constipation; Humans; Male; Naltrexone; Opioid-Induced Constipation; Quaternary Ammonium Compounds | 2022 |
Reductions in All-Cause Mortality Associated with the Use of Methylnaltrexone for Opioid-Induced Bowel Disorders: A Pooled Analysis.
Topics: Analgesics, Opioid; Chronic Pain; Constipation; Double-Blind Method; Humans; Naltrexone; Narcotic Antagonists; Randomized Controlled Trials as Topic; Retrospective Studies | 2023 |
Peripherally-active mu-opioid receptor antagonists for constipation in critically ill patients receiving opioids: A case-series and a systematic review and meta-analysis of the literature.
Topics: Adult; Analgesics, Opioid; Constipation; Critical Illness; Humans; Laxatives; Naltrexone; Narcotic Antagonists; Opioid-Induced Constipation; Retrospective Studies | 2023 |
Naldemedine for the treatment of opioid-induced constipation in adults with chronic noncancer pain.
Topics: Adult; Analgesics, Opioid; Chronic Pain; Constipation; Humans; Naltrexone; Opioid-Induced Constipation | 2020 |
Naldemedine for the Use of Management of Opioid Induced Constipation.
Topics: Analgesics, Opioid; Constipation; Humans; Naltrexone; Narcotic Antagonists; Opioid-Induced Constipation | 2020 |
[Management of adverse effects of opioid therapy].
Topics: Administration, Cutaneous; Administration, Oral; Analgesics, Opioid; Chronic Pain; Constipation; Drug-Related Side Effects and Adverse Reactions; Germany; Humans; Morphinans; Naltrexone; Narcotic Antagonists; Polyethylene Glycols; Quaternary Ammonium Compounds; Treatment Outcome | 2017 |
Evidence Based Review of Pharmacotherapy for Opioid-Induced Constipation in Noncancer Pain.
Topics: Analgesics, Opioid; Chronic Pain; Constipation; Evidence-Based Practice; Humans; Laxatives; Lubiprostone; Morphinans; Naltrexone; Narcotic Antagonists; Piperidines; Polyethylene Glycols; Quaternary Ammonium Compounds; Randomized Controlled Trials as Topic | 2018 |
Management of Opioid-Induced Constipation in Patients with Malignancy.
Topics: Analgesics, Opioid; Cancer Pain; Constipation; Enema; Gastrointestinal Agents; Gastrostomy; Humans; Laxatives; Morphinans; Naltrexone; Piperidines; Polyethylene Glycols; Practice Guidelines as Topic; Quaternary Ammonium Compounds | 2018 |
Mu-opioid antagonists for opioid-induced bowel dysfunction in people with cancer and people receiving palliative care.
Topics: Constipation; Defecation; Female; Gastrointestinal Agents; Humans; Intestinal Diseases; Male; Nalbuphine; Naloxone; Naltrexone; Narcotic Antagonists; Neoplasms; Opioid-Related Disorders; Oxycodone; Palliative Care; Piperidines; Quaternary Ammonium Compounds; Randomized Controlled Trials as Topic; Receptors, Opioid, mu | 2018 |
Methylnaltrexone bromide for the treatment of opioid-induced constipation.
Topics: Analgesics, Opioid; Chronic Pain; Clinical Trials as Topic; Constipation; Government Regulation; Half-Life; Humans; Naltrexone; Quality of Life; Quaternary Ammonium Compounds; Treatment Outcome | 2018 |
Opioid receptors in the GI tract: targets for treatment of both diarrhea and constipation in functional bowel disorders?
Topics: Analgesics, Opioid; Animals; Antidiarrheals; Constipation; Defecation; Diarrhea; Gastrointestinal Motility; Gastrointestinal Tract; Humans; Imidazoles; Inflammatory Bowel Diseases; Laxatives; Morphinans; Naltrexone; Narcotic Antagonists; Phenylalanine; Polyethylene Glycols; Quaternary Ammonium Compounds; Receptors, Opioid, mu; Signal Transduction | 2018 |
A meta-analysis of naldemedine for the treatment of opioid-induced constipation.
Topics: Analgesics, Opioid; Constipation; Dose-Response Relationship, Drug; Humans; Naltrexone; Narcotic Antagonists; Randomized Controlled Trials as Topic; Receptors, Opioid, mu | 2019 |
Efficacy of naldemedine for the treatment of opioid-induced constipation: A meta-analysis.
Topics: Analgesics, Opioid; Constipation; Defecation; Female; Gastrointestinal Motility; Humans; Male; Middle Aged; Naltrexone; Narcotic Antagonists; Recovery of Function; Treatment Outcome | 2019 |
Naldemedine: A Review in Opioid-Induced Constipation.
Topics: Analgesics, Opioid; Cancer Pain; Chronic Pain; Clinical Trials, Phase III as Topic; Constipation; Humans; Naltrexone; Narcotic Antagonists; Quality of Life | 2019 |
Pharmacological treatment of constipation in palliative care.
Topics: Analgesics, Opioid; Constipation; Humans; Injections, Subcutaneous; Laxatives; Naltrexone; Narcotic Antagonists; Palliative Care; Practice Guidelines as Topic; Quaternary Ammonium Compounds | 2013 |
Efficacy of pharmacological therapies for the treatment of opioid-induced constipation: systematic review and meta-analysis.
Topics: Alprostadil; Analgesics, Opioid; Benzofurans; Constipation; Female; Gastrointestinal Agents; Humans; Lubiprostone; Male; Naloxone; Naltrexone; Narcotic Antagonists; Peptides; Piperidines; Quaternary Ammonium Compounds; Receptors, Opioid, mu | 2013 |
Overview and treatment of opioid-induced constipation.
Topics: Analgesics, Opioid; Combined Modality Therapy; Constipation; Delayed-Action Preparations; Diet Therapy; Humans; Laxatives; Life Style; Naloxone; Naltrexone; Narcotic Antagonists; Piperidines; Quaternary Ammonium Compounds | 2013 |
[Constipation management in palliative care].
Topics: Administration, Oral; Aged; Constipation; Dose-Response Relationship, Drug; Female; Humans; Injections, Subcutaneous; Laxatives; Male; Middle Aged; Naltrexone; Narcotic Antagonists; Palliative Care; Quaternary Ammonium Compounds; Randomized Controlled Trials as Topic | 2013 |
Treatment of opioid-induced constipation: focus on the peripheral μ-opioid receptor antagonist methylnaltrexone.
Topics: Analgesics, Opioid; Clinical Trials as Topic; Constipation; Dietary Fiber; Humans; Laxatives; Naltrexone; Narcotic Antagonists; Pain; Quaternary Ammonium Compounds; Receptors, Opioid, mu | 2013 |
[Opiate induced constipation--mechanisms, relevance and treatment].
Topics: Administration, Cutaneous; Administration, Oral; Analgesics, Opioid; Constipation; Drug Therapy, Combination; Gastrointestinal Motility; Humans; Laxatives; Naltrexone; Narcotic Antagonists; Oxycodone; Quaternary Ammonium Compounds | 2013 |
Laxatives for the management of constipation in people receiving palliative care.
Topics: Analgesics, Opioid; Anthraquinones; Cathartics; Constipation; Humans; Lactulose; Magnesium Hydroxide; Naltrexone; Palliative Care; Paraffin; Quaternary Ammonium Compounds; Randomized Controlled Trials as Topic; Senna Extract | 2015 |
Naloxegol: A Novel Therapy in the Management of Opioid-Induced Constipation.
Topics: Analgesics, Opioid; Constipation; Drug Interactions; Humans; Morphinans; Naltrexone; Narcotic Antagonists; Pain; Polyethylene Glycols; Quality of Life; Quaternary Ammonium Compounds; Randomized Controlled Trials as Topic | 2016 |
Constipation: opioid antagonists in people prescribed opioids.
Topics: Analgesics, Opioid; Constipation; Gastrointestinal Agents; Humans; Naloxone; Naltrexone; Narcotic Antagonists; Piperidines; Quaternary Ammonium Compounds; Treatment Outcome | 2015 |
Opioid-induced constipation in chronic noncancer pain.
Topics: Analgesics, Opioid; Chloride Channel Agonists; Chronic Pain; Constipation; Humans; Lubiprostone; Morphinans; Naltrexone; Narcotic Antagonists; Polyethylene Glycols; Quaternary Ammonium Compounds; Receptors, Opioid, mu | 2016 |
Efficacy of methylnaltrexone for the treatment of opiod-induced constipation: a meta-analysis and systematic review.
Topics: Analgesics, Opioid; Chronic Pain; Constipation; Humans; Naltrexone; Narcotic Antagonists; Quaternary Ammonium Compounds; Receptors, Opioid, mu; Treatment Outcome | 2016 |
Constipation in Elderly Patients with Noncancer Pain: Focus on Opioid-Induced Constipation.
Topics: Aged; Analgesics, Opioid; Constipation; Health Personnel; Humans; Laxatives; Naltrexone; Narcotic Antagonists; Pain; Quaternary Ammonium Compounds; Receptors, Opioid, mu; Treatment Outcome | 2016 |
[News from the cochrane library: mu opioid antagonists for opioid-induced bowel dysfunction].
Topics: Analgesics, Opioid; Clinical Trials as Topic; Constipation; Gastrointestinal Transit; Humans; Nalbuphine; Naloxone; Naltrexone; Narcotic Antagonists; Piperidines; Quaternary Ammonium Compounds; Receptors, Opioid, mu | 2008 |
Opioid receptors in the gastrointestinal tract.
Topics: Animals; Constipation; Gastrointestinal Tract; Humans; Naloxone; Naltrexone; Narcotic Antagonists; Piperidines; Quaternary Ammonium Compounds; Receptors, Opioid | 2009 |
Methylnaltrexone: the answer to opioid-induced constipation?
Topics: Analgesics, Opioid; Animals; Constipation; Gastrointestinal Transit; Humans; Naltrexone; Quaternary Ammonium Compounds | 2009 |
[Methylnaltrexone. A new approach for therapy of opioid-induced obstipation].
Topics: Analgesics, Opioid; Clinical Trials as Topic; Constipation; Critical Care; Humans; Naltrexone; Narcotic Antagonists; Palliative Care; Quaternary Ammonium Compounds | 2009 |
Methylnaltrexone: a novel approach for the management of opioid-induced constipation in patients with advanced illness.
Topics: Analgesics, Opioid; Clinical Trials as Topic; Constipation; Defecation; Drug Approval; Gastrointestinal Motility; Humans; Injections, Intravenous; Injections, Subcutaneous; Laxatives; Naltrexone; Narcotic Antagonists; Palliative Care; Quaternary Ammonium Compounds; Treatment Outcome | 2009 |
Methylnaltrexone bromide: new drug for the treatment of opioid-induced bowel dysfunction.
Topics: Analgesics, Opioid; Clinical Trials as Topic; Constipation; Dose-Response Relationship, Drug; Drug Interactions; Gastrointestinal Transit; Half-Life; Humans; Infusions, Intravenous; Infusions, Subcutaneous; Laxatives; Naltrexone; Narcotic Antagonists; Postoperative Complications; Quaternary Ammonium Compounds | 2009 |
Methylnaltrexone.
Topics: Analgesics, Opioid; Constipation; Humans; Molecular Structure; Naltrexone; Quaternary Ammonium Compounds; Randomized Controlled Trials as Topic; Receptors, Opioid, mu; Treatment Outcome | 2010 |
The role of opioid receptor antagonists in the treatment of opioid-induced constipation: a review.
Topics: Analgesics, Opioid; Clinical Trials as Topic; Constipation; Delayed-Action Preparations; Drug Combinations; Humans; Laxatives; Naloxone; Naltrexone; Narcotic Antagonists; Oxycodone; Quaternary Ammonium Compounds | 2010 |
Methylnaltrexone: treatment for opioid-induced constipation.
Topics: Analgesics, Opioid; Constipation; Defecation; Humans; Naltrexone; Narcotic Antagonists; Pain, Intractable; Palliative Care; Quality of Life; Quaternary Ammonium Compounds | 2011 |
Methylnaltrexone bromide: research update of pharmacokinetics following parenteral administration.
Topics: Clinical Trials as Topic; Constipation; Humans; Injections, Intravenous; Injections, Subcutaneous; Naltrexone; Narcotic Antagonists; Palliative Care; Quaternary Ammonium Compounds | 2011 |
Laxatives or methylnaltrexone for the management of constipation in palliative care patients.
Topics: Analgesics, Opioid; Anthraquinones; Cathartics; Constipation; Humans; Lactulose; Magnesium Hydroxide; Naltrexone; Palliative Care; Paraffin; Quaternary Ammonium Compounds; Randomized Controlled Trials as Topic; Senna Extract | 2011 |
Management of opioid-induced constipation in cancer patients: focus on methylnaltrexone.
Topics: Analgesics, Opioid; Constipation; Humans; Naltrexone; Narcotic Antagonists; Neoplasms; Pain; Palliative Care; Quaternary Ammonium Compounds | 2012 |
Motility disorders of the colon and rectum.
Topics: Constipation; Diet; Dipeptides; Diverticulosis, Colonic; Gastrointestinal Agents; Gastrointestinal Transit; Humans; Naltrexone; Narcotic Antagonists; Peptides; Piperidines; Quaternary Ammonium Compounds; Rectal Diseases; Thiazepines; Tryptophan Hydroxylase | 2013 |
Laxatives or methylnaltrexone for the management of constipation in palliative care patients.
Topics: Aged; Constipation; Evidence-Based Nursing; Humans; Laxatives; Middle Aged; Naltrexone; Palliative Care; Quaternary Ammonium Compounds; Randomized Controlled Trials as Topic | 2013 |
Opioid-induced bowel dysfunction: pathophysiology and potential new therapies.
Topics: Constipation; Digestive System; Gastrointestinal Motility; Gastrointestinal Transit; Humans; Intestinal Obstruction; Naltrexone; Narcotic Antagonists; Narcotics; Postoperative Complications; Quaternary Ammonium Compounds; Receptors, Opioid; Water-Electrolyte Balance | 2003 |
Opioids and opioid receptors in the enteric nervous system: from a problem in opioid analgesia to a possible new prokinetic therapy in humans.
Topics: Analgesics, Opioid; Animals; Constipation; Enteric Nervous System; Gastrointestinal Motility; Humans; Naltrexone; Narcotic Antagonists; Piperidines; Quaternary Ammonium Compounds; Receptors, Opioid | 2004 |
Methylnaltrexone: MNTX.
Topics: Clinical Trials as Topic; Colic; Constipation; Flatulence; Humans; Injections, Intravenous; Naltrexone; Narcotic Antagonists; Quaternary Ammonium Compounds; Treatment Outcome | 2006 |
Methylnaltrexone mechanisms of action and effects on opioid bowel dysfunction and other opioid adverse effects.
Topics: Analgesics, Opioid; Constipation; Humans; Naltrexone; Narcotic Antagonists; Quaternary Ammonium Compounds | 2007 |
A review of methylnaltrexone, a peripheral opioid receptor antagonist, and its role in opioid-induced constipation.
Topics: Analgesics, Opioid; Constipation; Humans; Naltrexone; Narcotic Antagonists; Quaternary Ammonium Compounds | 2007 |
Cancer-related constipation.
Topics: Alprostadil; Constipation; Fatty Acids; Gastrointestinal Agents; Humans; Indoles; Lubiprostone; Naltrexone; Narcotic Antagonists; Neoplasms; Piperidines; Quaternary Ammonium Compounds; Serotonin Receptor Agonists | 2007 |
Mu-opioid antagonists for opioid-induced bowel dysfunction.
Topics: Constipation; Defecation; Gastrointestinal Agents; Humans; Intestinal Diseases; Nalbuphine; Naloxone; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders; Piperidines; Quaternary Ammonium Compounds; Receptors, Opioid, mu | 2008 |
Opioid antagonists in the treatment of opioid-induced constipation and pruritus.
Topics: Clinical Trials as Topic; Constipation; Humans; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Pruritus; Quaternary Ammonium Compounds | 2001 |
Incidence, prevalence, and management of opioid bowel dysfunction.
Topics: Analgesics, Opioid; Cathartics; Colic; Constipation; Data Collection; Gastroesophageal Reflux; Humans; Incidence; Intestines; Naltrexone; Narcotic Antagonists; Prevalence; Quaternary Ammonium Compounds; United States | 2001 |
A review of the potential role of methylnaltrexone in opioid bowel dysfunction.
Topics: Analgesics, Opioid; Animals; Constipation; Dose-Response Relationship, Drug; Gastrointestinal Motility; Gastrointestinal Transit; Humans; Intestines; Morphine; Naltrexone; Narcotic Antagonists; Quaternary Ammonium Compounds; Receptors, Opioid | 2001 |
Methylnaltrexone Progenics.
Topics: Analgesics, Opioid; Animals; Constipation; Humans; Naltrexone; Narcotic Antagonists; Quaternary Ammonium Compounds; Randomized Controlled Trials as Topic; Structure-Activity Relationship | 2002 |
36 trial(s) available for naltrexone and Constipation
| Article | Year |
|---|---|
Attrition of methylnaltrexone treatment-emergent adverse events in patients with chronic noncancer pain and opioid-induced constipation: a post hoc pooled analysis of two clinical trials.
Topics: Adult; Analgesics, Opioid; Chronic Pain; Constipation; Double-Blind Method; Humans; Naltrexone; Opioid-Induced Constipation; Quaternary Ammonium Compounds; Treatment Outcome | 2021 |
Methylnaltrexone for the treatment of opioid-induced constipation and gastrointestinal stasis in intensive care patients. Results from the MOTION trial.
Topics: Adult; Analgesics, Opioid; Constipation; Critical Care; Humans; Naltrexone; Opioid-Induced Constipation; Quaternary Ammonium Compounds | 2020 |
The influence of brain metastases on the central nervous system effects of methylnaltrexone: a post hoc analysis of 3 randomized, double-blind studies.
Topics: Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Brain Neoplasms; Central Nervous System; Constipation; Double-Blind Method; Female; Humans; Male; Middle Aged; Naltrexone; Quaternary Ammonium Compounds | 2021 |
The Influence of Age on Central Effects of Methylnaltrexone in Patients with Opioid-Induced Constipation.
Topics: Age Factors; Aged; Analgesics, Opioid; Constipation; Humans; Naltrexone; Opioid-Induced Constipation; Quaternary Ammonium Compounds; Treatment Outcome | 2021 |
A Phase 2b, Randomized, Double-Blind Placebo-Controlled Study to Evaluate the Efficacy and Safety of Naldemedine for the Treatment of Opioid-Induced Constipation in Patients with Chronic Noncancer Pain.
Topics: Adult; Analgesics, Opioid; Chronic Pain; Constipation; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Male; Middle Aged; Naltrexone; Narcotic Antagonists | 2017 |
Phase IIb, Randomized, Double-Blind, Placebo-Controlled Study of Naldemedine for the Treatment of Opioid-Induced Constipation in Patients With Cancer.
Topics: Administration, Oral; Aged; Analgesics, Opioid; Constipation; Defecation; Double-Blind Method; Female; Humans; Male; Middle Aged; Naltrexone; Narcotic Antagonists; Neoplasms; Opioid-Related Disorders | 2017 |
Naldemedine versus placebo for opioid-induced constipation (COMPOSE-1 and COMPOSE-2): two multicentre, phase 3, double-blind, randomised, parallel-group trials.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Chronic Pain; Constipation; Defecation; Double-Blind Method; Drug Administration Schedule; Female; Humans; Intention to Treat Analysis; Male; Middle Aged; Naltrexone; Narcotic Antagonists; Receptors, Opioid, mu; Young Adult | 2017 |
Long-Term Safety and Efficacy of Subcutaneous Methylnaltrexone in Patients with Opioid-Induced Constipation and Chronic Noncancer Pain: A Phase 3, Open-Label Trial.
Topics: Adult; Aged; Analgesics, Opioid; Chronic Pain; Constipation; Female; Humans; Injections, Subcutaneous; Male; Middle Aged; Naltrexone; Narcotic Antagonists; Quaternary Ammonium Compounds; Time | 2017 |
Randomized Phase III and Extension Studies of Naldemedine in Patients With Opioid-Induced Constipation and Cancer.
Topics: Adult; Aged; Analgesics, Opioid; Constipation; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Female; Follow-Up Studies; Humans; Japan; Male; Middle Aged; Naltrexone; Neoplasms; Opioid-Related Disorders; Pain Management; Reference Values; Risk Assessment; Severity of Illness Index; Treatment Outcome | 2017 |
Long-term use of naldemedine in the treatment of opioid-induced constipation in patients with chronic noncancer pain: a randomized, double-blind, placebo-controlled phase 3 study.
Topics: Adult; Aged; Analgesics, Opioid; Chronic Pain; Constipation; Double-Blind Method; Female; Humans; Male; Middle Aged; Naltrexone; Narcotic Antagonists; Quality of Life; Treatment Outcome | 2018 |
Identifying and Treating Opioid Side Effects: The Development of Methylnaltrexone.
Topics: Adult; Analgesics, Opioid; Constipation; Double-Blind Method; Female; Humans; Male; Naltrexone; Narcotic Antagonists; Quaternary Ammonium Compounds; Treatment Outcome | 2019 |
Absorption, distribution, metabolism, and excretion of radiolabeled naldemedine in healthy subjects.
Topics: Administration, Oral; Adult; Area Under Curve; Carbon Radioisotopes; Constipation; Healthy Volunteers; Humans; Inactivation, Metabolic; Intestinal Absorption; Male; Naltrexone; Nausea; Oxadiazoles; Tissue Distribution | 2019 |
Mitigation of Olanzapine-Induced Weight Gain With Samidorphan, an Opioid Antagonist: A Randomized Double-Blind Phase 2 Study in Patients With Schizophrenia.
Topics: Adult; Antipsychotic Agents; Constipation; Dizziness; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Least-Squares Analysis; Male; Middle Aged; Naltrexone; Narcotic Antagonists; Olanzapine; Schizophrenia; Sleepiness; Weight Gain | 2019 |
Onset of action of naldemedine in the treatment of opioid-induced constipation in patients with chronic noncancer pain: results from 2 randomized, placebo-controlled, phase 3 trials.
Topics: Adult; Aged; Analgesics, Opioid; Chronic Pain; Constipation; Double-Blind Method; Female; Humans; Male; Middle Aged; Naltrexone; Narcotic Antagonists; Time Factors; Treatment Outcome | 2019 |
Methylnaltrexone for opioid-induced constipation in pediatric oncology patients.
Topics: Adolescent; Analgesics, Opioid; Child; Child, Preschool; Constipation; Female; Humans; Male; Naltrexone; Narcotic Antagonists; Neoplasms; Pain; Quaternary Ammonium Compounds; Retrospective Studies | 2013 |
Efficacy and Tolerability of Subcutaneous Methylnaltrexone in Patients with Advanced Illness and Opioid-Induced Constipation: A Responder Analysis of 2 Randomized, Placebo-Controlled Trials.
Topics: Adult; Aged; Analgesics, Opioid; Constipation; Double-Blind Method; Female; Humans; Male; Middle Aged; Naltrexone; Narcotic Antagonists; Quaternary Ammonium Compounds; Treatment Outcome | 2015 |
Fixed-Dose Subcutaneous Methylnaltrexone in Patients with Advanced Illness and Opioid-Induced Constipation: Results of a Randomized, Placebo-Controlled Study and Open-Label Extension.
Topics: Aged; Analgesics, Opioid; Constipation; Double-Blind Method; Female; Humans; Injections, Subcutaneous; Male; Middle Aged; Naltrexone; Narcotic Antagonists; Patient Safety; Placebos; Quaternary Ammonium Compounds; Severity of Illness Index | 2015 |
Extended-release but not immediate-release and subcutaneous methylnaltrexone antagonizes the loperamide-induced delay of whole-gut transit time in healthy subjects.
Topics: Adult; Antidiarrheals; Constipation; Delayed-Action Preparations; Dose-Response Relationship, Drug; Drug Antagonism; Female; Gastrointestinal Motility; Gastrointestinal Transit; Humans; Injections, Subcutaneous; Loperamide; Male; Naltrexone; Narcotic Antagonists; Quaternary Ammonium Compounds; Young Adult | 2016 |
Protocol for a randomised control trial of methylnaltrexone for the treatment of opioid-induced constipation and gastrointestinal stasis in intensive care patients (MOTION).
Topics: Adult; Analgesics, Opioid; Blood-Brain Barrier; Constipation; Critical Care; Female; Gastrointestinal Motility; Humans; Laxatives; Male; Naltrexone; Narcotic Antagonists; Quaternary Ammonium Compounds | 2016 |
Treatment with methylnaltrexone is associated with increased survival in patients with advanced cancer.
Topics: Adult; Aged; Analgesics, Opioid; Constipation; Disease-Free Survival; Female; Humans; Kaplan-Meier Estimate; Laxatives; Male; Middle Aged; Naltrexone; Neoplasms; Quaternary Ammonium Compounds; Receptors, Opioid, mu | 2016 |
Phase II trial of subcutaneous methylnaltrexone in the treatment of severe opioid-induced constipation (OIC) in cancer patients: an exploratory study.
Topics: Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Constipation; Female; Humans; Injections, Subcutaneous; Male; Middle Aged; Naltrexone; Narcotic Antagonists; Neoplasm Staging; Neoplasms; Prognosis; Quaternary Ammonium Compounds | 2017 |
Randomized, Double-Blind Trial of Oral Methylnaltrexone for the Treatment of Opioid-Induced Constipation in Patients with Chronic Noncancer Pain.
Topics: Administration, Oral; Adult; Aged; Analgesics, Opioid; Chronic Pain; Constipation; Double-Blind Method; Female; Humans; Injections, Subcutaneous; Male; Middle Aged; Naltrexone; Narcotic Antagonists; Quaternary Ammonium Compounds; Receptors, Opioid, mu; Treatment Outcome | 2017 |
Methylnaltrexone for opioid-induced constipation in advanced illness.
Topics: Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Constipation; Defecation; Double-Blind Method; Female; Humans; Injections, Subcutaneous; Laxatives; Logistic Models; Male; Middle Aged; Naltrexone; Narcotic Antagonists; Quaternary Ammonium Compounds; Terminally Ill | 2008 |
Methylnaltrexone treatment of opioid-induced constipation in patients with advanced illness.
Topics: Analgesics, Opioid; Constipation; Defecation; Double-Blind Method; Humans; Laxatives; Naltrexone; Narcotic Antagonists; Pain, Intractable; Palliative Care; Quaternary Ammonium Compounds | 2009 |
Long-term safety and efficacy of morphine sulfate and naltrexone hydrochloride extended release capsules, a novel formulation containing morphine and sequestered naltrexone, in patients with chronic, moderate to severe pain.
Topics: Adolescent; Adult; Aged; Analgesics, Opioid; Chronic Disease; Constipation; Delayed-Action Preparations; Drug Combinations; Female; Humans; Male; Middle Aged; Morphine; Naltrexone; Narcotic Antagonists; Nausea; Pain; Pain Measurement; Treatment Outcome | 2010 |
Effect of subcutaneous methylnaltrexone on patient-reported constipation symptoms.
Topics: Analgesics, Opioid; Back Pain; Chronic Disease; Constipation; Double-Blind Method; Female; Humans; Injections, Subcutaneous; Male; Middle Aged; Naltrexone; Narcotic Antagonists; Quaternary Ammonium Compounds | 2011 |
Subcutaneous methylnaltrexone for treatment of opioid-induced constipation in patients with chronic, nonmalignant pain: a randomized controlled study.
Topics: Adult; Aged; Analgesics, Opioid; Chi-Square Distribution; Constipation; Defecation; Double-Blind Method; Female; Humans; Intention to Treat Analysis; Male; Middle Aged; Naltrexone; Narcotic Antagonists; Pain; Quaternary Ammonium Compounds; Surveys and Questionnaires; Treatment Outcome | 2011 |
Methylnaltrexone for opioid-induced constipation in patients with advanced illness: a 3-month open-label treatment extension study.
Topics: Aged; Aged, 80 and over; Analgesics, Opioid; Constipation; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Humans; Injections, Subcutaneous; Male; Middle Aged; Naltrexone; Narcotic Antagonists; Quaternary Ammonium Compounds; Substance Withdrawal Syndrome; Time Factors; Treatment Outcome | 2011 |
Efficacy of subcutaneous methylnaltrexone in the treatment of opioid-induced constipation: a responder post hoc analysis.
Topics: Adult; Analgesics, Opioid; Constipation; Double-Blind Method; Female; Humans; Injections, Subcutaneous; Male; Middle Aged; Naltrexone; Narcotic Antagonists; Placebos; Quaternary Ammonium Compounds; Treatment Outcome | 2011 |
Subcutaneous methylnaltrexone for treatment of acute opioid-induced constipation: phase 2 study in rehabilitation after orthopedic surgery.
Topics: Aged; Analgesics, Opioid; Constipation; Double-Blind Method; Female; Humans; Injections, Subcutaneous; Male; Middle Aged; Naltrexone; Narcotic Antagonists; Orthopedic Procedures; Pilot Projects; Quaternary Ammonium Compounds; Rehabilitation; Treatment Outcome | 2012 |
Characterization of abdominal pain during methylnaltrexone treatment of opioid-induced constipation in advanced illness: a post hoc analysis of two clinical trials.
Topics: Abdominal Pain; Adult; Aged; Analgesics, Opioid; Colic; Constipation; Double-Blind Method; Female; Humans; Male; Middle Aged; Naltrexone; Narcotic Antagonists; Pain Measurement; Quaternary Ammonium Compounds | 2011 |
6β-naltrexol, a peripherally selective opioid antagonist that inhibits morphine-induced slowing of gastrointestinal transit: an exploratory study.
Topics: Adult; Animals; Breath Tests; Constipation; Cross-Over Studies; Double-Blind Method; Gastrointestinal Transit; Humans; Male; Miosis; Morphine; Naltrexone; Narcotic Antagonists; Pain; Pain Measurement; Pilot Projects; Placebos; Young Adult | 2011 |
Does co-administration of a non-selective opiate antagonist enhance acceleration of transit by a 5-HT4 agonist in constipation-predominant irritable bowel syndrome? A randomized controlled trial.
Topics: Adult; Constipation; Double-Blind Method; Drug Therapy, Combination; Female; Gastrointestinal Motility; Humans; Indoles; Irritable Bowel Syndrome; Male; Middle Aged; Naltrexone; Narcotic Antagonists; Radionuclide Imaging; Serotonin 5-HT4 Receptor Agonists; Serotonin Receptor Agonists | 2007 |
Assessment of nalmefene glucuronide as a selective gut opioid antagonist.
Topics: Adult; Arousal; Autonomic Nervous System; Constipation; Dose-Response Relationship, Drug; Gastrointestinal Motility; Humans; Male; Methadone; Naltrexone; Narcotic Antagonists; Neurologic Examination; Opioid-Related Disorders; Substance Withdrawal Syndrome | 1995 |
Methylnaltrexone for reversal of constipation due to chronic methadone use: a randomized controlled trial.
Topics: Adult; Analgesics, Opioid; Constipation; Double-Blind Method; Female; Gastrointestinal Transit; Humans; Male; Methadone; Naltrexone; Narcotic Antagonists; Quaternary Ammonium Compounds; Statistics, Nonparametric; Substance Withdrawal Syndrome | 2000 |
Oral methylnaltrexone for opioid-induced constipation.
Topics: Administration, Oral; Adult; Analgesics, Opioid; Constipation; Humans; Methadone; Naltrexone; Narcotic Antagonists; Narcotics; Quaternary Ammonium Compounds; Single-Blind Method | 2000 |
73 other study(ies) available for naltrexone and Constipation
| Article | Year |
|---|---|
Real-World Patient Characteristics and Treatment Patterns of Naldemedine for the Treatment of Opioid-Induced Constipation in Patients with Cancer: A Multicenter Retrospective Chart Review Study.
Topics: Analgesics, Opioid; Constipation; Humans; Naltrexone; Neoplasms; Opioid-Induced Constipation; Retrospective Studies | 2021 |
Naldemedine-induced opioid withdrawal syndrome with severe psychiatric symptoms in an advanced cervical cancer patient without brain metastasis.
Topics: Adult; Analgesics, Opioid; Brain Neoplasms; Constipation; Female; Humans; Naltrexone; Narcotic Antagonists; Uterine Cervical Neoplasms | 2022 |
Use of naldemedine is associated with reduced incidence of hyperactive delirium in cancer patients with opioid-induced constipation: A nationwide retrospective cohort study in Japan.
Topics: Analgesics, Opioid; Constipation; Delirium; Humans; Ileus; Incidence; Japan; Naltrexone; Neoplasms; Opioid-Induced Constipation; Retrospective Studies | 2022 |
Post-marketing surveillance of the safety and effectiveness of naldemedine in the management of opioid-induced constipation in patients with cancer pain in Japan.
Topics: Analgesics, Opioid; Cancer Pain; Constipation; Humans; Japan; Naltrexone; Narcotic Antagonists; Neoplasms; Opioid-Induced Constipation; Product Surveillance, Postmarketing; Prospective Studies | 2022 |
Rational Design, Chemical Syntheses, and Biological Evaluations of Peripherally Selective Mu Opioid Receptor Ligands as Potential Opioid Induced Constipation Treatment.
Topics: Analgesics, Opioid; Constipation; Humans; Ligands; Naltrexone; Narcotic Antagonists; Opioid-Induced Constipation; Receptors, Opioid, mu | 2022 |
Opioid withdrawal syndrome developing after long-term administration of naldemedine.
Topics: Aged; Analgesics, Opioid; Constipation; Female; Humans; Naltrexone; Narcotic Antagonists; Quality of Life | 2022 |
[Efficacy Survey of Naldemedine in the Poor-performance Status Group].
Topics: Analgesics, Opioid; Constipation; Humans; Naltrexone; Narcotic Antagonists; Retrospective Studies | 2022 |
A retrospective study of the efficacy and safety of naldemedine for opioid-induced constipation in thoracic cancer patients.
Topics: Analgesics, Opioid; Constipation; Humans; Naltrexone; Narcotic Antagonists; Opioid-Induced Constipation; Prospective Studies; Retrospective Studies; Thoracic Neoplasms | 2022 |
Naloxone Versus Methylnaltrexone for Opioid-Induced Constipation in Critically Ill Patients.
Topics: Adult; Analgesics, Opioid; Constipation; Critical Illness; Humans; Naloxone; Naltrexone; Narcotic Antagonists; Opioid-Induced Constipation; Pain; Prospective Studies; Quaternary Ammonium Compounds; Retrospective Studies | 2023 |
Factors associated with non-response to naldemedine for opioid-induced constipation in cancer patients: A subgroup analysis.
Topics: Analgesics, Opioid; Constipation; Gastrointestinal Agents; Humans; Morphinans; Naltrexone; Narcotic Antagonists; Neoplasms; Opioid-Induced Constipation; Quality of Life; Retrospective Studies | 2022 |
Mu-Opioid Antagonists for the Treatment of Opioid-Induced Bowel Dysfunction.
Topics: Analgesics, Opioid; Constipation; Humans; Naltrexone; Narcotic Antagonists; Opioid-Induced Constipation | 2023 |
Clinical Drug-Drug Interaction Studies to Evaluate the Effects of a P-Glycoprotein Inhibitor, CYP3A Inhibitors, and a CYP3A Inducer on the Pharmacokinetics of Naldemedine in Healthy Subjects.
Topics: Adolescent; Adult; Analgesics, Opioid; Area Under Curve; Clinical Trials, Phase I as Topic; Constipation; Cytochrome P-450 CYP3A Inducers; Cytochrome P-450 CYP3A Inhibitors; Female; Healthy Volunteers; Humans; Male; Middle Aged; Naltrexone; Receptors, Opioid, mu; Young Adult | 2020 |
Efficacy of Naldemedine in the Management of Constipation in a Patient with Severe COVID-19 Receiving Mechanical Ventilation.
Topics: Constipation; COVID-19; COVID-19 Drug Treatment; Humans; Naltrexone; Respiration, Artificial | 2021 |
Analysis of Predictive Factors for Diarrhea after the Administration of Naldemedine.
Topics: Aged; Analgesics, Opioid; Constipation; Cytochrome P-450 CYP3A Inhibitors; Diarrhea; Female; Humans; Laxatives; Logistic Models; Male; Middle Aged; Naltrexone; Narcotic Antagonists; Odds Ratio; Receptors, Opioid, mu; Risk Factors | 2021 |
Naldemedine: First Global Approval.
Topics: Analgesics, Opioid; Chronic Pain; Clinical Trials as Topic; Constipation; Drug Approval; Humans; Japan; Laxatives; Naltrexone; United States | 2017 |
Naldemedine effective in treating opioid-induced constipation.
Topics: Analgesics, Opioid; Clinical Trials, Phase II as Topic; Constipation; Defecation; Humans; Naltrexone; Narcotic Antagonists; Randomized Controlled Trials as Topic; Treatment Outcome | 2017 |
Naldemedine (Symproic) for opioid-induced constipation.
Topics: Analgesics, Opioid; Constipation; Defecation; Gastrointestinal Motility; Humans; Naltrexone; Narcotic Antagonists; Treatment Outcome | 2017 |
Randomized Phase III and Extension Studies of Naldemedine in Patients With Opioid-Induced Constipation and Cancer.
Topics: Analgesics, Opioid; Constipation; Humans; Naltrexone; Narcotic Antagonists; Neoplasms | 2018 |
Reply to Y. Yagi et al.
Topics: Analgesics, Opioid; Constipation; Humans; Naltrexone; Neoplasms | 2018 |
Methylation Products of 6β- N-Heterocyclic Substituted Naltrexamine Derivatives as Potential Peripheral Opioid Receptor Modulators.
Topics: Analgesics, Opioid; Animals; CHO Cells; Constipation; Cricetulus; Diarrhea; Drug Partial Agonism; Gastrointestinal Agents; Gastrointestinal Transit; Imidazoles; Methylation; Mice; Molecular Docking Simulation; Morphine; Naltrexone; Narcotic Antagonists; Nociception; Phenylalanine; Quaternary Ammonium Compounds; Radioligand Assay; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 2018 |
Methylnaltrexone-Associated Bowel Perforation in Postoperative Opioid-Induced Constipation and Ogilvie Syndrome: A Case Report.
Topics: Analgesics, Opioid; Colonic Pseudo-Obstruction; Constipation; Decompression, Surgical; Humans; Hydromorphone; Intestinal Perforation; Low Back Pain; Male; Methadone; Middle Aged; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders; Oxycodone; Postoperative Complications; Quaternary Ammonium Compounds; Spinal Stenosis | 2019 |
[A New Twist on the Administration of Naldemedine for Opioid-Induced Constipation in an Outpatient].
Topics: Aged; Aged, 80 and over; Analgesics, Opioid; Cancer Pain; Constipation; Diarrhea; Female; Humans; Male; Middle Aged; Naltrexone; Neoplasms; Outpatients | 2018 |
Population Pharmacokinetics and Exposure-Response Relationships of Naldemedine.
Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Analgesics, Opioid; Body Weight; Cancer Pain; Chronic Pain; Constipation; Creatinine; Dose-Response Relationship, Drug; Female; Humans; Male; Middle Aged; Models, Biological; Naltrexone | 2018 |
Optimal treatment of opioid induced constipation in daily clinical practice - an observational study.
Topics: Aged; Analgesics, Opioid; Constipation; Female; Fentanyl; Humans; Laxatives; Male; Middle Aged; Naltrexone; Narcotic Antagonists; Neoplasms; Oxycodone; Pain Management; Prospective Studies; Quaternary Ammonium Compounds; Retrospective Studies; Surveys and Questionnaires | 2019 |
Delta-opioid receptor antagonist naltrindole reduces oxycodone addiction and constipation in mice.
Topics: Analgesics; Animals; Constipation; Drug Tolerance; Male; Mice; Mice, Inbred C57BL; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders; Oxycodone; Receptors, Opioid, delta; Respiratory Insufficiency | 2019 |
A Response to: Challenges in Recruiting Patients to a Controlled Feasibility Study of a Drug for Opioid-Induced Constipation: Lessons From the Population With Advanced Cancer.
Topics: Analgesics, Opioid; Constipation; Feasibility Studies; Humans; Naltrexone; Narcotic Antagonists; Neoplasms | 2019 |
A preliminary study of the effect of naldemedine tosylate on opioid-induced nausea and vomiting.
Topics: Aged; Analgesics, Opioid; Antiemetics; Constipation; Female; Humans; Incidence; Male; Middle Aged; Morphine; Naltrexone; Narcotic Antagonists; Nausea; Oxycodone; Receptors, Opioid; Retrospective Studies; Vomiting | 2020 |
Methylnaltrexone is safe in cancer patients with peritoneal carcinomatosis.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Child; Child, Preschool; Constipation; Female; Humans; Infant; Male; Middle Aged; Naltrexone; Peritoneal Neoplasms; Quaternary Ammonium Compounds; Retrospective Studies; Treatment Outcome; Young Adult | 2019 |
Methylnaltrexone use in a seventeen-month-old female with progressive cancer and rectal prolapse.
Topics: Analgesics, Opioid; Constipation; Female; Humans; Infant; Leukemia, Myeloid, Acute; Naltrexone; Narcotic Antagonists; Palliative Care; Quaternary Ammonium Compounds; Rectal Prolapse | 2013 |
Pharmacologic treatment of opioid-induced constipation.
Topics: Analgesics, Opioid; Clinical Trials, Phase III as Topic; Constipation; Humans; Naltrexone; Narcotic Antagonists; Quaternary Ammonium Compounds; Receptors, Opioid, mu | 2013 |
Unexpected side effect of methylnaltrexone.
Topics: Aged; Constipation; Female; Humans; Naltrexone; Narcotic Antagonists; Palliative Care; Quaternary Ammonium Compounds; Vomiting | 2013 |
A prospective study of methylnaltrexone for opioid-induced constipation in advanced illness: should we use it or not?
Topics: Analgesics, Opioid; Constipation; Female; Humans; Laxatives; Male; Naltrexone; Narcotic Antagonists | 2013 |
The role of methylnaltrexone in opioid-induced constipation.
Topics: Analgesics, Opioid; Constipation; Humans; Naltrexone; Narcotic Antagonists; Quaternary Ammonium Compounds | 2013 |
Methylnaltrexone in palliative care: further research is needed.
Topics: Analgesics, Opioid; Constipation; Female; Humans; Laxatives; Male; Naltrexone; Narcotic Antagonists | 2014 |
Uptake of methylnaltrexone in Australian patients with opioid-induced constipation: a review of the number of prescriptions presented in the first 12 months of subsidisation.
Topics: Analgesics, Opioid; Australia; Constipation; Humans; Naltrexone; Narcotic Antagonists; Needs Assessment; Palliative Care; Prescriptions; Quaternary Ammonium Compounds | 2013 |
Paediatric palliative care: intravenous methylnaltrexone relieves constipation.
Topics: Administration, Intravenous; Analgesics, Opioid; Child, Preschool; Constipation; Heroin; Humans; Male; Naltrexone; Narcotic Antagonists; Palliative Care; Quaternary Ammonium Compounds | 2013 |
GI relief may come sooner than later for patients with chronic noncancer pain.
Topics: Adult; Analgesics, Opioid; Chronic Pain; Constipation; Drug Approval; Humans; Morphinans; Naltrexone; Narcotic Antagonists; Polyethylene Glycols; Quaternary Ammonium Compounds; United States; United States Food and Drug Administration | 2014 |
Off-label uses of alvimopan and methylnaltrexone.
Topics: Analgesics, Opioid; Constipation; Gastrointestinal Agents; Humans; Ileus; Naltrexone; Narcotic Antagonists; Off-Label Use; Piperidines; Postoperative Complications; Quaternary Ammonium Compounds | 2014 |
Methylnaltrexone for opioid-induced constipation in patients at the end of life.
Topics: Analgesics, Opioid; Constipation; Humans; Naltrexone; Quaternary Ammonium Compounds; Terminal Care | 2015 |
Methylnaltrexone for Opioid-Induced Constipation in Children and Adolescents and Young Adults with Progressive Incurable Cancer at the End of Life.
Topics: Adolescent; Analgesics, Opioid; Child; Child, Preschool; Constipation; Double-Blind Method; Female; Humans; Infant; Male; Medical Audit; Naltrexone; Narcotic Antagonists; Neoplasms; Quaternary Ammonium Compounds; Retrospective Studies; Terminally Ill; Young Adult | 2015 |
Opioid-Induced Constipation Part 2: Newer Therapies #295.
Topics: Analgesics, Opioid; Constipation; Humans; Morphinans; Naloxone; Naltrexone; Narcotic Antagonists; Polyethylene Glycols; Quaternary Ammonium Compounds | 2015 |
Rapid Tolerance to Constipating Effects of Loperamide in Healthy Subjects.
Topics: Constipation; Healthy Volunteers; Humans; Loperamide; Naltrexone | 2016 |
Methylnaltrexone for the Treatment of Constipation in Critically Ill Children.
Topics: Abdominal Pain; Analgesics, Opioid; Child; Constipation; Critical Illness; Defecation; Humans; Infant; Laxatives; Male; Morphine; Naltrexone; Narcotic Antagonists; Quaternary Ammonium Compounds; Treatment Outcome | 2016 |
Methylnaltrexone Versus Naloxone for Opioid-Induced Constipation in the Medical Intensive Care Unit.
Topics: Adult; Analgesics, Opioid; Constipation; Critical Illness; Electronic Health Records; Female; Fentanyl; Heart Rate; Humans; Intensive Care Units; Male; Middle Aged; Naltrexone; Narcotic Antagonists; Prospective Studies; Quaternary Ammonium Compounds; Retrospective Studies | 2017 |
Opioid side effects--mechanism-based therapy.
Topics: Analgesics, Opioid; Constipation; Humans; Laxatives; Naltrexone; Narcotic Antagonists; Quaternary Ammonium Compounds | 2008 |
The Food and Drug Administration approves methylnaltrexone bromide for opioid-induced constipation.
Topics: Analgesics, Opioid; Constipation; Drug Approval; Humans; Naltrexone; Narcotic Antagonists; Quaternary Ammonium Compounds; United States; United States Food and Drug Administration | 2008 |
Managing opioid-induced constipation.
Topics: Analgesics, Opioid; Constipation; Humans; Laxatives; Naltrexone; Narcotic Antagonists; Quaternary Ammonium Compounds | 2008 |
Methylnaltrexone (Relistor) for opioid induced constipation.
Topics: Analgesics, Opioid; Constipation; Drug Interactions; Humans; Naltrexone; Narcotic Antagonists; Quaternary Ammonium Compounds; Randomized Controlled Trials as Topic; Terminal Care | 2008 |
Methylnaltrexone for opioid-induced constipation in advanced illness.
Topics: Analgesics, Opioid; Constipation; Drug Tolerance; Humans; Laxatives; Naltrexone; Narcotic Antagonists; Quaternary Ammonium Compounds | 2008 |
Methylnaltrexone for opioid-induced constipation in advanced illness.
Topics: Administration, Oral; Analgesics, Opioid; Constipation; Humans; Injections, Subcutaneous; Laxatives; Naltrexone; Narcotic Antagonists; Quaternary Ammonium Compounds | 2008 |
Drug approvals: '08 in review. Methylnaltrexone (Relistor).
Topics: Analgesics, Opioid; Constipation; Humans; Naltrexone; Narcotic Antagonists; Quaternary Ammonium Compounds | 2009 |
Methylnaltrexone for opioid-induced constipation.
Topics: Analgesics, Opioid; Constipation; Humans; Injections, Subcutaneous; Naltrexone; Narcotic Antagonists; Quality of Life; Quaternary Ammonium Compounds | 2009 |
[Successful treatment of treatment-resistant opioid-induced constipation in a patient with incomplete paraplegia with methylnaltrexone].
Topics: Aged; Cervical Vertebrae; Constipation; Fecal Impaction; Humans; Injections, Subcutaneous; Male; Naltrexone; Narcotic Antagonists; Narcotics; Paraplegia; Postoperative Complications; Quaternary Ammonium Compounds; Spinal Cord Compression | 2009 |
Methylnaltrexone: new drug. Opiate-induced constipation: barely more effective than placebo.
Topics: Analgesics, Opioid; Clinical Trials as Topic; Constipation; Double-Blind Method; Drug Approval; Europe; Humans; Naltrexone; Narcotic Antagonists; Quaternary Ammonium Compounds; Terminally Ill | 2009 |
Methylnaltrexone: a subcutaneous treatment for opioid-induced constipation in palliative care patients.
Topics: Aged, 80 and over; Algorithms; Analgesics, Opioid; Causality; Constipation; Cost of Illness; Decision Trees; Female; Humans; Injections, Subcutaneous; Laxatives; Naltrexone; Narcotic Antagonists; Nursing Assessment; Palliative Care; Quaternary Ammonium Compounds | 2009 |
Methylnaltrexone bromide for the treatment of opioid-induced constipation in patients with advanced illness--a cost-effectiveness analysis.
Topics: Adolescent; Adult; Aged; Analgesics, Opioid; Constipation; Cost-Benefit Analysis; Humans; Laxatives; Middle Aged; Naltrexone; Narcotic Antagonists; Quality-Adjusted Life Years; Quaternary Ammonium Compounds; Terminally Ill; Young Adult | 2010 |
Emerging new therapeutic options for the management of opioid induced constipation.
Topics: Alprostadil; Analgesics, Opioid; Constipation; Delayed-Action Preparations; Drug Therapy, Combination; Humans; Laxatives; Lubiprostone; Naloxone; Naltrexone; Narcotic Antagonists; Oxycodone; Quaternary Ammonium Compounds | 2010 |
Methylnaltrexone in the treatment of opioid-induced constipation in cancer patients receiving palliative care: willingness-to-pay and cost-benefit analysis.
Topics: Adolescent; Adult; Age Distribution; Analgesics, Opioid; Constipation; Consumer Behavior; Cost of Illness; Cost-Benefit Analysis; Female; Health Care Costs; Humans; Male; Middle Aged; Naltrexone; Narcotic Antagonists; Neoplasms; Ontario; Pain; Palliative Care; Patient Acceptance of Health Care; Quaternary Ammonium Compounds; Sex Distribution; Socioeconomic Factors; Treatment Outcome; Young Adult | 2011 |
Methylnaltrexone: treatment for opioid-induced constipation--not convinced yet.
Topics: Analgesics, Opioid; Constipation; Humans; Naltrexone; Narcotic Antagonists; Quaternary Ammonium Compounds | 2011 |
Treating constipation in palliative care: the impact of other factors aside from opioids.
Topics: Aged; Analgesics, Opioid; Constipation; Female; Humans; Laxatives; Male; Medical Records; Middle Aged; Naltrexone; Narcotic Antagonists; Neoplasms; New South Wales; Outcome Assessment, Health Care; Palliative Care; Quaternary Ammonium Compounds; Risk Factors | 2012 |
Methylnaltrexone in treatment of opioid-induced constipation in a pediatric patient.
Topics: Analgesics, Opioid; Child, Preschool; Chronic Pain; Constipation; Humans; Male; Naltrexone; Narcotic Antagonists; Pediatrics; Quaternary Ammonium Compounds | 2012 |
Management of constipation in patients receiving palliative care.
Topics: Analgesics, Opioid; Constipation; Humans; Laxatives; Naltrexone; Narcotic Antagonists; Pain; Palliative Care; Quaternary Ammonium Compounds | 2011 |
Use of methylnaltrexone for the treatment of opioid-induced constipation in critical care patients.
Topics: Aged; Analgesics, Opioid; Constipation; Critical Care; Female; Gastrointestinal Motility; Humans; Laxatives; Male; Middle Aged; Naltrexone; Narcotic Antagonists; Quaternary Ammonium Compounds; Retrospective Studies; Statistics, Nonparametric | 2012 |
Non-analgesic effects of opioids: management of opioid-induced constipation by peripheral opioid receptor antagonists: prevention or withdrawal?
Topics: Age Factors; Analgesics, Opioid; Constipation; Defecation; Drug Combinations; Gastrointestinal Tract; Humans; Laxatives; Naloxone; Naltrexone; Narcotic Antagonists; Pain; Predictive Value of Tests; Prevalence; Quaternary Ammonium Compounds; Receptors, Opioid; Risk Factors | 2012 |
Methylnaltrexone for opioid-induced constipation in a pediatric oncology patient.
Topics: Analgesics, Opioid; Brain Neoplasms; Child; Constipation; Female; Humans; Morphine; Naltrexone; Narcotic Antagonists; Neuroblastoma; Pain; Quaternary Ammonium Compounds | 2012 |
Subsidised use of methylnaltrexone in Australia for palliative care.
Topics: Analgesics, Opioid; Australia; Constipation; Drug Utilization; Humans; Laxatives; Naltrexone; Narcotic Antagonists; Palliative Care; Quaternary Ammonium Compounds | 2012 |
Pain management research goes beyond the obvious.
Topics: Analgesics, Opioid; Animals; Anti-Inflammatory Agents; Constipation; Humans; Naltrexone; Narcotic Antagonists; Pain; Piperidines; Pyridines; Quaternary Ammonium Compounds; Receptors, Opioid, mu | 2006 |
Relistor approved for opioid-related constipation.
Topics: Analgesics, Opioid; Constipation; Drug Approval; Humans; Injections, Subcutaneous; Naltrexone; Narcotic Antagonists; Palliative Care; Quaternary Ammonium Compounds; Receptors, Opioid, mu; United States; United States Food and Drug Administration | 2008 |
Cancer pain remedy wins orphan drug status.
Topics: Blood-Brain Barrier; Constipation; Drug Therapy, Combination; Humans; Morphine; Naltrexone; Narcotic Antagonists; Nausea; Neoplasms; Orphan Drug Production; Pain; Quaternary Ammonium Compounds; United States; United States Food and Drug Administration | 1996 |
Effects of intravenous methylnaltrexone on opioid-induced gut motility and transit time changes in subjects receiving chronic methadone therapy: a pilot study.
Topics: Adult; Analgesics, Opioid; Constipation; Female; Gastrointestinal Motility; Gastrointestinal Transit; Humans; Male; Methadone; Middle Aged; Naltrexone; Narcotic Antagonists; Pilot Projects; Quaternary Ammonium Compounds | 1999 |
Managing constipation that's opioid-induced.
Topics: Administration, Oral; Adult; Analgesics, Opioid; Breast Neoplasms; Chemistry, Pharmaceutical; Constipation; Female; Humans; Methadone; Naloxone; Naltrexone; Narcotic Antagonists; Pain; Quaternary Ammonium Compounds | 2000 |
Methylnaltrexone reverses opioid-induced constipation.
Topics: Administration, Oral; Analgesics, Opioid; Clinical Trials, Phase II as Topic; Constipation; Humans; Methadone; Naltrexone; Narcotic Antagonists; Quaternary Ammonium Compounds | 2002 |
Evidence for the delivery of narcotic antagonists to the colon as their glucuronide conjugates.
Topics: Animals; Colon; Constipation; Diarrhea; Dose-Response Relationship, Drug; Glucuronates; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Skin Temperature; Substance-Related Disorders | 1988 |