Page last updated: 2024-11-08
asperphenamate
Description
asperphenamate: isolated from culture filtrate & mycelium of Aspergillus flavipes ATCC 11013; structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
asperphenamate : A carboxylic ester resulting from the formal condensation of the carboxy group of N-benzoyl-L-phenylalanine with the hydroxy group of N-benzoyl-L-phenylalaninol. A metabolite found in several Pencillium and Aspergillus species, as well as in plants as a product of endophytic fungi. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]
Cross-References
Synonyms (30)
| Synonym |
|---|
| nsc-306231 |
| asperphenamate |
| 63631-36-7 |
| ACON0_001364 |
| ACON1_002244 |
| MEGXM0_000143 |
| NCGC00170024-01 |
| BRD-K77990213-001-01-6 |
| CHEMBL496238 |
| anabellamide |
| n-benzoyl-l-phenylalanine,2s-(benzoylamino)-3-phenylpropyl ester |
| (2s)-2-benzamido-3-phenylpropyl (2s)-2-benzamido-3-phenylpropanoate |
| asjanin |
| auranamide |
| CHEBI:145105 |
| (2s)-2-benzamido-3-phenylpropyl n-benzoyl-l-phenylalaninate |
| [(2s)-2-benzamido-3-phenylpropyl] (2s)-2-benzamido-3-phenylpropanoate |
| n-benzoylphenylalanine-2-benzamido-3-phenyl propyl ester |
| unii-2h4md59yvt |
| 2h4md59yvt , |
| nsc 306231 |
| 3-phenyl-2-(benzoylamino)propanoic acid 2-(benzoylamino)-3-phenylpropyl ester |
| asperphenamate_120258 |
| HY-129578 |
| CS-0106762 |
| l-phenylalanine, n-benzoyl-, (2s)-2-(benzoylamino)-3-phenylpropyl ester |
| n-benzoyl-phenylalanine 2-benzoylamino-3-phenylpropyl ester |
| l-phenylalanine, n-benzoyl-, 2-(benzoylamino)-3-phenylpropyl ester, (s)- |
| n-benzoyl-l-phenylalaninol n-benzoyl-l-phenylalaninate |
| AKOS040732480 |
Research Excerpts
Overview
Asperphenamate is a natural phenylalanine derivative.
Roles (1)
| Role | Description |
|---|
| antineoplastic agent | A substance that inhibits or prevents the proliferation of neoplasms. |
| [role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] |
Drug Classes (3)
| Class | Description |
|---|
| L-phenylalanine derivative | A proteinogenic amino acid derivative resulting from reaction of L-phenylalanine at the amino group or the carboxy group, or from the replacement of any hydrogen of L-phenylalanine by a heteroatom. |
| benzamides | |
| carboxylic ester | An ester of a carboxylic acid, R(1)C(=O)OR(2), where R(1) = H or organyl and R(2) = organyl. |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] |
Bioassays (5)
| Assay ID | Title | Year | Journal | Article |
|---|
| AID649278 | Antiproliferative activity against human Bel7402 cells after 3 days by MTT assay | 2012 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 22, Issue:6
| Synthesis and in vitro antitumor activity of asperphenamate derivatives as autophagy inducer. |
| AID649276 | Antiproliferative activity against human MCF7 cells after 3 days by MTT assay | 2012 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 22, Issue:6
| Synthesis and in vitro antitumor activity of asperphenamate derivatives as autophagy inducer. |
| AID649300 | Thermodynamic solubility of the compound in phosphate buffer at pH 7.4 at 1 mg after 10 mins by HPLC -UV analysis | 2012 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 22, Issue:6
| Synthesis and in vitro antitumor activity of asperphenamate derivatives as autophagy inducer. |
| AID649277 | Antiproliferative activity against human HeLa cells after 3 days by MTT assay | 2012 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 22, Issue:6
| Synthesis and in vitro antitumor activity of asperphenamate derivatives as autophagy inducer. |
| AID377421 | Antioxidant activity assessed as DPPH-radical scavenging activity | 2006 | Journal of natural products, Jul, Volume: 69, Issue:7
| Diterpenes from Leucas aspera inhibiting prostaglandin-induced contractions. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Research
Studies (9)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (33.33) | 29.6817 |
| 2010's | 4 (44.44) | 24.3611 |
| 2020's | 2 (22.22) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Market Indicators
Research Demand Index: 24.06
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.
| Metric | This Compound (vs All) |
|---|
| Research Demand Index | 24.06 (24.57) | | Research Supply Index | 2.30 (2.92) | | Research Growth Index | 4.72 (4.65) | | Search Engine Demand Index | 23.28 (26.88) | | Search Engine Supply Index | 2.00 (0.95) |
| |
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 9 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |