clonidine has been researched along with Constipation in 8 studies
Clonidine: An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION.
clonidine (amino form) : A clonidine that is 4,5-dihydro-1H-imidazol-2-amine in which one of the amino hydrogens is replaced by a 2,6-dichlorophenyl group.
Constipation: Infrequent or difficult evacuation of FECES. These symptoms are associated with a variety of causes, including low DIETARY FIBER intake, emotional or nervous disturbances, systemic and structural disorders, drug-induced aggravation, and infections.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Although it is known that both clonidine and loperamide cause delayed colonic transit in mice, these models of drug-induced experimental constipation have not yet been fully characterized." | 3.75 | Characterization of two models of drug-induced constipation in mice and evaluation of mustard oil in these models. ( Doihara, H; Ito, H; Kawabata-Shoda, E; Kojima, R; Nozawa, K; Yokoyama, T, 2009) |
| "Constipation is a major gastrointestinal motility disorder with clinical need for effective drugs." | 1.40 | Effects of novel TRPA1 receptor agonist ASP7663 in models of drug-induced constipation and visceral pain. ( Doihara, H; Itou, H; Kaku, H; Keto, Y; Kojima, R; Nozawa, K; Yokoyama, T, 2014) |
| "Constipation is one of the most common gastrointestinal complaints with a highly prevalent and often chronic functional gastrointestinal disorder affecting health-related quality of life." | 1.39 | Laxative effects of Salecan on normal and two models of experimental constipated mice. ( Chen, J; Chen, P; Jia, P; Xiu, A; Zhan, Y; Zhang, J; Zhao, Y; Zhou, M, 2013) |
| " Dose-response curves were obtained for each drug individually; for morphine:clonidine at 1:3, 1:1, and 1:0." | 1.29 | Interaction of morphine and clonidine on gastrointestinal transit in mice. ( Pol, O; Puig, MM; Warner, W, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (37.50) | 18.7374 |
| 1990's | 2 (25.00) | 18.2507 |
| 2000's | 1 (12.50) | 29.6817 |
| 2010's | 2 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zhou, M | 1 |
| Jia, P | 1 |
| Chen, J | 1 |
| Xiu, A | 1 |
| Zhao, Y | 1 |
| Zhan, Y | 1 |
| Chen, P | 1 |
| Zhang, J | 1 |
| Kojima, R | 2 |
| Nozawa, K | 2 |
| Doihara, H | 2 |
| Keto, Y | 1 |
| Kaku, H | 1 |
| Yokoyama, T | 2 |
| Itou, H | 1 |
| Kawabata-Shoda, E | 1 |
| Ito, H | 1 |
| Jung, N | 1 |
| Schmidt, U | 1 |
| Ortmann, G | 1 |
| Scholtze, P | 1 |
| Sanger, GJ | 1 |
| Wardle, KA | 1 |
| Puig, MM | 1 |
| Pol, O | 1 |
| Warner, W | 1 |
| Bauer, GE | 1 |
| Hellestrand, KJ | 1 |
| Amery, AK | 1 |
| Bossaert, H | 1 |
| Fagard, RH | 1 |
| Verstraete, M | 1 |
1 trial available for clonidine and Constipation
| Article | Year |
|---|---|
Clonidine versus methyldopa. A double blind cross-over study comparing side effects of clonidine and methyldopa administered together with chlorthalidone at a dosage producing the same blood pressure lowering effect.
Topics: Antihypertensive Agents; Blood Pressure; Chlorthalidone; Clinical Trials as Topic; Clonidine; Consti | 1972 |
7 other studies available for clonidine and Constipation
| Article | Year |
|---|---|
Laxative effects of Salecan on normal and two models of experimental constipated mice.
Topics: Animals; beta-Glucans; Clonidine; Constipation; Defecation; Disease Models, Animal; Dose-Response Re | 2013 |
Effects of novel TRPA1 receptor agonist ASP7663 in models of drug-induced constipation and visceral pain.
Topics: Abdominal Pain; Analgesics; Animals; Calcium; Calcium Channels; Clonidine; Colon; Constipation; Gast | 2014 |
Characterization of two models of drug-induced constipation in mice and evaluation of mustard oil in these models.
Topics: Animals; Atropine; Clonidine; Constipation; Disease Models, Animal; Dose-Response Relationship, Drug | 2009 |
[Spontaneous colonic perforation during chronic intermittent peritoneal dialysis (author's transl)].
Topics: Clonidine; Colonic Diseases; Constipation; Female; Humans; Intestinal Mucosa; Intestinal Perforation | 1981 |
Constipation evoked by 5-HT3-receptor antagonism: evidence for heterogeneous efficacy among different antagonists in guinea-pigs.
Topics: Animals; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Clonidine; Colon; Const | 1994 |
Interaction of morphine and clonidine on gastrointestinal transit in mice.
Topics: Adrenergic alpha-Antagonists; Analysis of Variance; Animals; Benzofurans; Clonidine; Constipation; D | 1996 |
Letter: Pseudo-obstruction due to clonidine.
Topics: Clonidine; Constipation; Female; Humans; Intestinal Obstruction; Middle Aged | 1976 |