neostigmine has been researched along with Constipation in 37 studies
Neostigmine: A cholinesterase inhibitor used in the treatment of myasthenia gravis and to reverse the effects of muscle relaxants such as gallamine and tubocurarine. Neostigmine, unlike PHYSOSTIGMINE, does not cross the blood-brain barrier.
neostigmine : A quaternary ammonium ion comprising an anilinium ion core having three methyl substituents on the aniline nitrogen, and a 3-[(dimethylcarbamoyl)oxy] substituent at position 3. It is a parasympathomimetic which acts as a reversible acetylcholinesterase inhibitor.
Constipation: Infrequent or difficult evacuation of FECES. These symptoms are associated with a variety of causes, including low DIETARY FIBER intake, emotional or nervous disturbances, systemic and structural disorders, drug-induced aggravation, and infections.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Neostigmine is traditionally administered intravenously for treatment of acute colonic pseudo-obstruction (ACPO), though use is associated with administration constraints and adverse effects." | 7.88 | Efficacy and Safety of Subcutaneous Neostigmine for Ileus, Acute Colonic Pseudo-obstruction, or Refractory Constipation. ( Campbell, ME; Grant, M; Greenland, M; Kram, B; Sommer, C; Wells, C, 2018) |
| "Neostigmine significantly decreases colonic compliance in patients with refractory chronic constipation." | 7.83 | Evaluating the safety and the effects on colonic compliance of neostigmine during motility testing in patients with chronic constipation. ( Acosta, A; Bharucha, AE; Camilleri, M; Halland, M; Lee, T; Mouchli, MA; Parthasarathy, G; Vijayvargiya, P, 2016) |
| "Neostigmine has been used in some cases of refractory constipation in critically ill adults." | 5.37 | Neostigmine in the treatment of refractory constipation in critically ill children. ( Botrán, M; García, A; González, R; López-Herce, J; Solana, MJ; Urbano, J, 2011) |
| "Constipation is a common complication of amyotrophic lateral sclerosis (ALS), especially as the disease progresses." | 5.33 | Neostigmine: an alternative treatment for constipation. ( Fu, A, 2005) |
| "Neostigmine is traditionally administered intravenously for treatment of acute colonic pseudo-obstruction (ACPO), though use is associated with administration constraints and adverse effects." | 3.88 | Efficacy and Safety of Subcutaneous Neostigmine for Ileus, Acute Colonic Pseudo-obstruction, or Refractory Constipation. ( Campbell, ME; Grant, M; Greenland, M; Kram, B; Sommer, C; Wells, C, 2018) |
| "Neostigmine significantly decreases colonic compliance in patients with refractory chronic constipation." | 3.83 | Evaluating the safety and the effects on colonic compliance of neostigmine during motility testing in patients with chronic constipation. ( Acosta, A; Bharucha, AE; Camilleri, M; Halland, M; Lee, T; Mouchli, MA; Parthasarathy, G; Vijayvargiya, P, 2016) |
| "A case of severe constipation is described in a 75-year- old cancer patient receiving methadone for pain." | 3.77 | Neostigmine for the treatment of gastrointestinal atony: a report of one case. ( Papa, P; Turconi, L, 2011) |
| " Patients treated with Ceruletide (n = 30, dosage of Ceruletide 2 ng/kg/min." | 2.65 | [Treatment of intestinal atony following gynecologic operations. Study on the effectiveness and tolerance of ceruletide]. ( Baur, M; Heinrich, D; Kubli, F; Schmid, H; Schulz-Wendtland, R; von Fournier, D, 1984) |
| "Neostigmine has been used in some cases of refractory constipation in critically ill adults." | 1.37 | Neostigmine in the treatment of refractory constipation in critically ill children. ( Botrán, M; García, A; González, R; López-Herce, J; Solana, MJ; Urbano, J, 2011) |
| "Neostigmine has also been successfully used for the management of recalcitrant constipation." | 1.35 | Management of constipation in the elderly: emerging therapeutic strategies. ( Kapoor, S, 2008) |
| "Constipation is a common complication of amyotrophic lateral sclerosis (ALS), especially as the disease progresses." | 1.33 | Neostigmine: an alternative treatment for constipation. ( Fu, A, 2005) |
| "Severe constipation is a debilitating concomitant of complete traumatic thoracic spinal cord injury." | 1.27 | Colonic dysfunction in patients with thoracic spinal cord injury. ( Bradley, WE; Downey, N; Glick, ME; Haldeman, S; Hoehler, F; Meshkinpour, H, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 17 (45.95) | 18.7374 |
| 1990's | 2 (5.41) | 18.2507 |
| 2000's | 9 (24.32) | 29.6817 |
| 2010's | 8 (21.62) | 24.3611 |
| 2020's | 1 (2.70) | 2.80 |
| Authors | Studies |
|---|---|
| Xu, C | 1 |
| Cong, J | 1 |
| Liu, T | 1 |
| Jiao, C | 1 |
| Li, M | 1 |
| Yu, Y | 1 |
| Zhang, Z | 1 |
| Zhang, S | 1 |
| Li, Y | 1 |
| Kram, B | 1 |
| Greenland, M | 1 |
| Grant, M | 1 |
| Campbell, ME | 1 |
| Wells, C | 1 |
| Sommer, C | 1 |
| Guardiola, B | 1 |
| Llompart-Pou, JA | 1 |
| Ibáñez, J | 1 |
| Raurich, JM | 1 |
| Mouchli, MA | 1 |
| Camilleri, M | 3 |
| Lee, T | 1 |
| Parthasarathy, G | 1 |
| Vijayvargiya, P | 1 |
| Halland, M | 1 |
| Acosta, A | 1 |
| Bharucha, AE | 3 |
| Corsetti, M | 1 |
| Pagliaro, G | 1 |
| Demedts, I | 1 |
| Deloose, E | 1 |
| Gevers, A | 1 |
| Scheerens, C | 1 |
| Rommel, N | 1 |
| Tack, J | 1 |
| Low, PA | 1 |
| Burton, D | 1 |
| Gehrking, TL | 1 |
| Zinsmeister, AR | 2 |
| Kapoor, S | 1 |
| Ravi, K | 1 |
| Rhoten, D | 1 |
| Bakken, T | 1 |
| Jessop, M | 1 |
| Choo, K | 1 |
| Little, M | 1 |
| Papa, P | 1 |
| Turconi, L | 1 |
| González, R | 1 |
| López-Herce, J | 1 |
| García, A | 1 |
| Botrán, M | 1 |
| Solana, MJ | 1 |
| Urbano, J | 1 |
| Thomas, MC | 1 |
| Erstad, BL | 1 |
| WANGEL, AG | 1 |
| DELLER, DJ | 2 |
| Fu, A | 1 |
| Lagrue, G | 1 |
| Cormier, S | 1 |
| Mautrait, C | 1 |
| Diviné, C | 1 |
| Rubiales, AS | 1 |
| Hernansanz, S | 1 |
| Gutiérrez, C | 1 |
| Del Valle, ML | 1 |
| Flores, LA | 1 |
| Singal, AK | 1 |
| Rosman, AS | 2 |
| Bauman, WA | 2 |
| Korsten, MA | 2 |
| Ong, SP | 1 |
| Choong, CF | 1 |
| Chaparala, G | 1 |
| Monga, A | 1 |
| Spungen, AM | 1 |
| Murrell, TG | 1 |
| von Fournier, D | 1 |
| Baur, M | 1 |
| Schmid, H | 1 |
| Schulz-Wendtland, R | 1 |
| Heinrich, D | 1 |
| Kubli, F | 1 |
| Glick, ME | 1 |
| Meshkinpour, H | 1 |
| Haldeman, S | 1 |
| Hoehler, F | 1 |
| Downey, N | 1 |
| Bradley, WE | 1 |
| Thurtle, OA | 1 |
| Allen, AP | 1 |
| Walters, MT | 1 |
| Kitchen, JV | 1 |
| Smith, CL | 1 |
| Cawley, MI | 1 |
| Battle, WM | 1 |
| Snape, WJ | 1 |
| Alavi, A | 1 |
| Cohen, S | 1 |
| Braunstein, S | 1 |
| Grotz, RL | 1 |
| Pemberton, JH | 1 |
| Levin, KE | 1 |
| Bell, AM | 1 |
| Hanson, RB | 1 |
| Meunier, P | 1 |
| Rochas, A | 1 |
| Lambert, R | 1 |
| Berndt, SF | 1 |
| Smith, AN | 2 |
| Varma, JS | 1 |
| Binnie, NR | 1 |
| Papachrysostomou, M | 1 |
| Sasaki, D | 1 |
| Kido, A | 1 |
| Yoshida, Y | 1 |
| Cyba-Altunbay, S | 1 |
| Bauer, J | 1 |
| Kirwan, WO | 1 |
| McConnell, AA | 1 |
| Mitchell, WD | 1 |
| Eastwood, MA | 1 |
| Champion, P | 1 |
| Waller, SL | 1 |
| Misiewicz, JJ | 1 |
| Hodgson, WJ | 1 |
| Anezaki, T | 1 |
| Briggs, JC | 1 |
| Dobson-Smyth, WE | 1 |
| Livingston, A | 1 |
| Pike, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Evaluating the Safety and Efficacy of Different Routes of Neostigmine Administration for Acute Colonic Pseudo Obstruction: a Prospective Randomized Trial[NCT04951726] | Phase 4 | 90 participants (Anticipated) | Interventional | 2022-02-04 | Recruiting | ||
| A Prospective, Randomized Trial of Enteral Naloxone Versus a Traditional Bowel Regimen in Prevention of Constipation and Decreased Gastric Motility in Critically Ill Trauma Patients[NCT00799201] | Phase 4 | 3 participants (Actual) | Interventional | 2007-08-31 | Terminated (stopped due to Naloxone became unavailable due to manufacturing shortatges requiring the study to be terminated.) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for neostigmine and Constipation
| Article | Year |
|---|---|
Recent concepts in the management of bowel problems after spinal cord injury.
Topics: Colon; Colonic Diseases, Functional; Constipation; Drug Therapy, Combination; Glycopyrrolate; Humans | 2006 |
9 trials available for neostigmine and Constipation
| Article | Year |
|---|---|
Pilot study of pyridostigmine in constipated patients with autonomic neuropathy.
Topics: Adolescent; Adult; Aged; Autonomic Nervous System; Autonomic Nervous System Diseases; Cholinesterase | 2008 |
Phenotypic variation of colonic motor functions in chronic constipation.
Topics: Adult; Catheterization; Cholinesterase Inhibitors; Chronic Disease; Colon; Compliance; Constipation; | 2010 |
Safety of enteral naloxone and i.v. neostigmine when used to relieve constipation.
Topics: Administration, Oral; Administration, Rectal; Adolescent; Adult; Aged; Arrhythmias, Cardiac; Colic; | 2003 |
Neostigmine for refractory constipation in advanced cancer patients.
Topics: Adult; Aged; Aged, 80 and over; Cholinesterase Inhibitors; Chronic Disease; Constipation; Female; Hu | 2006 |
Intramuscular neostigmine and glycopyrrolate safely accelerated bowel evacuation in patients with spinal cord injury and defecatory disorders.
Topics: Adult; Blood Pressure; Constipation; Cross-Over Studies; Defecation; Double-Blind Method; Glycopyrro | 2008 |
[Treatment of intestinal atony following gynecologic operations. Study on the effectiveness and tolerance of ceruletide].
Topics: Blood Pressure; Ceruletide; Clinical Trials as Topic; Constipation; Defecation; Female; Gastrointest | 1984 |
Rectal wall contractility in healthy subjects and in patients with chronic severe constipation.
Topics: Adult; Chronic Disease; Constipation; Female; Glucagon; Humans; Male; Manometry; Muscle Contraction; | 1993 |
[Therapy of prolonged postoperative intestinal atony following interventions on the aorto-iliac circulation. Results of a prospective randomized study with ceruletide lyophilysate versus neostigmine].
Topics: Aorta, Abdominal; Blood Vessel Prosthesis; Ceruletide; Clinical Trials as Topic; Constipation; Gastr | 1985 |
Action of different bran preparations on colonic function.
Topics: Constipation; Diverticulum, Colon; Edible Grain; Gastrointestinal Motility; Humans; Neostigmine; Par | 1974 |
27 other studies available for neostigmine and Constipation
| Article | Year |
|---|---|
The colonic motility and classification of patients with slow transit constipation by high-resolution colonic manometry.
Topics: Colon; Constipation; Female; Humans; Male; Manometry; Neostigmine | 2022 |
Efficacy and Safety of Subcutaneous Neostigmine for Ileus, Acute Colonic Pseudo-obstruction, or Refractory Constipation.
Topics: Acute Disease; Adult; Aged; Bradycardia; Cholinesterase Inhibitors; Colonic Pseudo-Obstruction; Cons | 2018 |
Prophylaxis Versus Treatment Use of Laxative for Paralysis of Lower Gastrointestinal Tract in Critically Ill Patients.
Topics: Adult; Aged; Constipation; Critical Illness; Defecation; Drug Administration Schedule; Enema; Female | 2016 |
Evaluating the safety and the effects on colonic compliance of neostigmine during motility testing in patients with chronic constipation.
Topics: Adult; Bradycardia; Cholinesterase Inhibitors; Chronic Disease; Colon; Constipation; Female; Gastroi | 2016 |
Pan-Colonic Pressurizations Associated With Relaxation of the Anal Sphincter in Health and Disease: A New Colonic Motor Pattern Identified Using High-Resolution Manometry.
Topics: Abdominal Wall; Adult; Anal Canal; Case-Control Studies; Cholinesterase Inhibitors; Chronic Disease; | 2017 |
Management of constipation in the elderly: emerging therapeutic strategies.
Topics: Age Factors; Aged; Aged, 80 and over; Alprostadil; Benzofurans; Constipation; Humans; Lubiprostone; | 2008 |
Acute colonic pseudo-obstruction in paediatric oncology patients.
Topics: Antineoplastic Agents; Child; Colonic Pseudo-Obstruction; Constipation; Female; Humans; Male; Neosti | 2010 |
Neostigmine for the treatment of gastrointestinal atony: a report of one case.
Topics: Aged; Analgesics, Opioid; Constipation; Female; Humans; Injections, Subcutaneous; Methadone; Neoplas | 2011 |
Neostigmine in the treatment of refractory constipation in critically ill children.
Topics: Adolescent; Cathartics; Child; Child, Preschool; Cholinesterase Inhibitors; Constipation; Drug Resis | 2011 |
INTESTINAL MOTILITY IN MAN. 3. MECHANISMS OF CONSTIPATION AND DIARRHEA WITH PARTICULAR REFERENCE TO THE IRRITABLE COLON SYNDROME.
Topics: Colitis; Colitis, Ulcerative; Colon; Colonic Diseases, Functional; Constipation; Diarrhea; Digestion | 1965 |
Neostigmine: an alternative treatment for constipation.
Topics: Aged; Amyotrophic Lateral Sclerosis; Colonic Pseudo-Obstruction; Constipation; Critical Illness; Fem | 2005 |
[Stopping smoking and constipation].
Topics: Cholinesterase Inhibitors; Constipation; Female; Follow-Up Studies; Humans; Magnesium; Middle Aged; | 2006 |
Neostigmine in the treatment of severe constipation.
Topics: Constipation; Female; Humans; Middle Aged; Neostigmine; Parasympathomimetics; Treatment Outcome | 2007 |
Intestinal motility in man: the effect of bradykinin on the motility of the distal colon.
Topics: Bradykinin; Catheterization; Colon; Colonic Diseases; Constipation; Diarrhea; Female; Gastrointestin | 1967 |
Colonic dysfunction in patients with thoracic spinal cord injury.
Topics: Adult; Colon; Constipation; Evoked Potentials, Somatosensory; Humans; Male; Middle Aged; Motor Neuro | 1984 |
Intractable constipation in malignant phaeochromocytoma: combined treatment with adrenergic blockade and cholinergic drugs.
Topics: Constipation; Female; Humans; Middle Aged; Neostigmine; Phentolamine; Pheochromocytoma | 1984 |
Colonic dysfunction in diabetes mellitus.
Topics: Action Potentials; Adolescent; Adult; Colon; Constipation; Diabetes Mellitus; Diabetes Mellitus, Typ | 1980 |
Motor activity of the sigmoid colon in chronic constipation: comparative study with normal subjects.
Topics: Adolescent; Adult; Aged; Colon, Sigmoid; Constipation; Female; Food; Gastrointestinal Motility; Huma | 1979 |
[Botulism].
Topics: Adolescent; Antitoxins; Botulism; Cardiac Pacing, Artificial; Constipation; Diarrhea; Female; German | 1978 |
Disordered colorectal motility in intractable constipation following hysterectomy.
Topics: Adult; Anal Canal; Carbachol; Colon; Constipation; Female; Gastrointestinal Motility; Humans; Hyster | 1990 |
An endoscopic method to study the relationship between bowel habit and motility of the ascending and sigmoid colon.
Topics: Adolescent; Adult; Aged; Colon; Colon, Sigmoid; Colonic Diseases, Functional; Colonoscopy; Constipat | 1986 |
Some cases of the irritable bowel syndrome studied by intraluminal pressure recordings.
Topics: Adolescent; Adult; Child; Colon; Colonic Diseases, Functional; Constipation; Diarrhea; Dietary Carbo | 1973 |
Colonic motility in constipation or diarrhoea.
Topics: Colon; Constipation; Diarrhea; Food; Gastrointestinal Motility; Humans; Neostigmine | 1972 |
An interim report on the production of colonic diverticula in the rabbit.
Topics: Animals; Body Weight; Bread; Butter; Chloralose; Colon; Constipation; Diet; Disease Models, Animal; | 1972 |
[Experimental and clinical observation of postoperative chronic obstipation].
Topics: Abdomen; Adult; Animals; Chronic Disease; Colon; Constipation; Dogs; Electromyography; Gastrointesti | 1964 |
Death due to a combination of treatment and disease.
Topics: Child; Constipation; Female; Humans; Intestinal Absorption; Megacolon; Neostigmine | 1969 |
The effect of an alcoholic extract of the leaves of Phytolacea americana on mecamylamine toxicity in mice and rats.
Topics: Animals; Blood Pressure; Cathartics; Constipation; Ethanol; Mecamylamine; Mice; Neostigmine; Plant E | 1970 |