desipramine has been researched along with Constipation in 8 studies
Desipramine: A tricyclic dibenzazepine compound that potentiates neurotransmission. Desipramine selectively blocks reuptake of norepinephrine from the neural synapse, and also appears to impair serotonin transport. This compound also possesses minor anticholinergic activity, through its affinity to muscarinic receptors.
desipramine : A dibenzoazepine consisting of 10,11-dihydro-5H-dibenzo[b,f]azepine substituted on nitrogen with a 3-(methylamino)propyl group.
Constipation: Infrequent or difficult evacuation of FECES. These symptoms are associated with a variety of causes, including low DIETARY FIBER intake, emotional or nervous disturbances, systemic and structural disorders, drug-induced aggravation, and infections.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This single-center, 12-week, double-blind, prospective, controlled-concentration study randomized 121 chronic back pain patients without major depression to active placebo (benztropine mesylate) or to predetermined low, medium, or high concentrations of desipramine (targets were 50, 110, and 150 ng/mL, respectively) or fluoxetine (targets were 100, 200, and 400 ng/mL, respectively)." | 5.12 | Efficacy of noradrenergic and serotonergic antidepressants in chronic back pain: a preliminary concentration-controlled trial. ( Abramson, I; Atkinson, JH; Capparelli, EV; Garfin, SR; Matthews, SC; Slater, MA; Wallace, MS; Zisook, S, 2007) |
| " The aim of this study was to assess the clinical efficacy and safety of cognitive-behavioral therapy (CBT) against education (EDU) and desipramine (DES) against placebo (PLA) in female patients with moderate to severe FBD (irritable bowel syndrome, functional abdominal pain, painful constipation, and unspecified FBD)." | 5.10 | Cognitive-behavioral therapy versus education and desipramine versus placebo for moderate to severe functional bowel disorders. ( Akman, D; Bangdiwala, SI; Blackman, CJ; Bradshaw, B; Dalton, CB; Diamant, NE; Drossman, DA; Duncan, S; Emmott, S; Frusciante, K; Hu, Y; Jia, H; Koch, GG; Le, T; Li, JZ; Meyer, K; Mikula, K; Morris, CB; Proffitt, V; Toner, BB; Whitehead, WE, 2003) |
| "Somatic side effects of antidepressant medications and of depression and anxiety were quantified in depressed patients before and after 4 weeks of treatment with amitriptyline (N = 11), or desipramine (N = 12)." | 3.66 | Somatic symptoms in depression and antidepressants. ( Claghorn, JL; Mathew, RJ; Reck, JJ; Thapar, R; Weinman, ML, 1983) |
| "Treatment with desipramine results in differing degrees of subjective side effects and changes in vital signs across the life cycle." | 2.41 | Side effects of desipramine and age. ( Bilich, C; Galanter, CA; Walsh, BT, 2002) |
| "Symptomatic orthostatic hypotension, the most common side effect encountered, occurred early in treatment at low desipramine plasma concentrations." | 1.26 | Major adverse reactions during desipramine treatment: relationship to plasma drug concentrations, concomitant antipsychotic treatment, and patient characteristics. ( Bock, J; Bowers, MB; Jatlow, PI; Nelson, JC; Quinlan, DM, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (50.00) | 18.7374 |
| 1990's | 1 (12.50) | 18.2507 |
| 2000's | 3 (37.50) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Galanter, CA | 1 |
| Bilich, C | 1 |
| Walsh, BT | 1 |
| Drossman, DA | 1 |
| Toner, BB | 1 |
| Whitehead, WE | 1 |
| Diamant, NE | 1 |
| Dalton, CB | 1 |
| Duncan, S | 1 |
| Emmott, S | 1 |
| Proffitt, V | 1 |
| Akman, D | 1 |
| Frusciante, K | 1 |
| Le, T | 1 |
| Meyer, K | 1 |
| Bradshaw, B | 1 |
| Mikula, K | 1 |
| Morris, CB | 1 |
| Blackman, CJ | 1 |
| Hu, Y | 1 |
| Jia, H | 1 |
| Li, JZ | 1 |
| Koch, GG | 1 |
| Bangdiwala, SI | 1 |
| KRAKOWSKI, AJ | 1 |
| Atkinson, JH | 1 |
| Slater, MA | 1 |
| Capparelli, EV | 1 |
| Wallace, MS | 1 |
| Zisook, S | 1 |
| Abramson, I | 1 |
| Matthews, SC | 1 |
| Garfin, SR | 1 |
| Nelson, JC | 1 |
| Jatlow, PI | 1 |
| Bock, J | 1 |
| Quinlan, DM | 1 |
| Bowers, MB | 1 |
| Mathew, RJ | 1 |
| Weinman, ML | 1 |
| Thapar, R | 1 |
| Reck, JJ | 1 |
| Claghorn, JL | 1 |
| Salah, RS | 1 |
| Cameron, OG | 1 |
| Tissot, R | 1 |
| Gaillard, JM | 1 |
| Guggisberg, M | 1 |
| Gauthier, G | 1 |
| de Ajuriaguerra, J | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Efficacy of Antidepressants in Chronic Back Pain[NCT00018200] | Phase 2 | 130 participants (Actual) | Interventional | 1999-04-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for desipramine and Constipation
| Article | Year |
|---|---|
Side effects of desipramine and age.
Topics: Adolescent; Adult; Age Factors; Appetite; Blood Pressure; Child; Constipation; Desipramine; Female; | 2002 |
2 trials available for desipramine and Constipation
| Article | Year |
|---|---|
Cognitive-behavioral therapy versus education and desipramine versus placebo for moderate to severe functional bowel disorders.
Topics: Adult; Antidepressive Agents, Tricyclic; Cognitive Behavioral Therapy; Colonic Diseases, Functional; | 2003 |
Efficacy of noradrenergic and serotonergic antidepressants in chronic back pain: a preliminary concentration-controlled trial.
Topics: Adrenergic Uptake Inhibitors; Adult; Aged; Back Pain; Capsules; Chronic Disease; Constipation; Desip | 2007 |
5 other studies available for desipramine and Constipation
| Article | Year |
|---|---|
TREATMENT OF SEVERE DEPRESSION WITH DESIPRAMINE: LONG-TERM TRIAL AND FOLLOW-UP.
Topics: Constipation; Depression; Depressive Disorder; Depressive Disorder, Major; Desipramine; Drug Hyperse | 1964 |
Major adverse reactions during desipramine treatment: relationship to plasma drug concentrations, concomitant antipsychotic treatment, and patient characteristics.
Topics: Adult; Age Factors; Aged; Antipsychotic Agents; Constipation; Delirium; Depressive Disorder; Desipra | 1982 |
Somatic symptoms in depression and antidepressants.
Topics: Adult; Amitriptyline; Anxiety; Autonomic Nervous System Diseases; Constipation; Depressive Disorder; | 1983 |
Pilocarpine for anticholinergic adverse effects associated with desipramine treatment.
Topics: Antidepressive Agents, Tricyclic; Constipation; Depressive Disorder; Desipramine; Humans; Male; Midd | 1996 |
[Treatment of Parkinsonism with oral L-DOPA combined with a decarboxylase inhibitor (Ro IV 46.02)].
Topics: Adult; Aged; Anemia, Hemolytic; Aromatic Amino Acid Decarboxylase Inhibitors; Blood Cell Count; Carb | 1969 |