(n,n-bis(2-chloroethyl))-2-aminoethyl-3-((acridin-9-yl)amino)propionate profile

The compound you've described, **(n,n-bis(2-chloroethyl))-2-aminoethyl-3-((acridin-9-yl)amino)propionate**, is a complex molecule with a unique structure and potential for research. It contains several functional groups that could contribute to its activity.

Here's a breakdown of the molecule and its potential implications:

* **Structure:** This compound is a derivative of the acridine molecule. It has a long, flexible alkyl chain containing a nitrogen mustard group (bis(2-chloroethyl)amino). The acridine moiety is known to intercalate into DNA, while the nitrogen mustard group is a potent alkylating agent.
* **Potential for Research:** The combination of these functional groups suggests this compound could be investigated for its potential as an anti-cancer agent. Here's how:
* **DNA Intercalation:** The acridine moiety can bind to DNA, potentially interfering with replication and transcription.
* **DNA Alkylation:** The nitrogen mustard group can react with DNA, leading to cross-linking and damage. This damage can trigger cell death or inhibit cell division, ultimately preventing tumor growth.

**Why is it Important for Research?**

While the specific compound you mentioned might not have been extensively studied, understanding its structure provides valuable insights into its potential applications. This molecule belongs to a class of compounds that are being explored for their potential in cancer therapy. Research in this area is crucial for developing new treatments for cancer and improving the efficacy and safety of current therapies.

**Important Note:** Research with this compound should be conducted in a controlled laboratory setting with proper safety precautions. Nitrogen mustards are potent chemicals that can be hazardous to human health.

**Additional Research:**

To learn more about this specific compound or similar molecules, you can consult scientific databases like PubChem or search for research publications on nitrogen mustard derivatives and acridine-based anti-cancer drugs.

(N,N-bis(2-chloroethyl))-2-aminoethyl-3-((acridin-9-yl)amino)propionate: an alkylating agent; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

ID Source	ID
PubMed CID	6433104
CHEMBL ID	2111082
SCHEMBL ID	685675
MeSH ID	M0493011

Synonym
2-[bis(2-chloroethyl)amino]ethyl 3-(acridin-9-ylamino)propanoate
s 303
unii-25571657uw
amustaline
pic 1
(n,n-bis(2-chloroethyl))-2-aminoethyl-3-((acridin-9-yl)amino)propionate
25571657uw ,
220180-88-1
beta-alanine, n-9-acridinyl-, 2-(bis(2-chloroethyl)amino)ethyl ester
SCHEMBL685675
.beta.-alanine, n-9-acridinyl-, 2-(bis(2-chloroethyl)amino)ethyl ester
s-303
2-(bis(2-chloroethyl)amino)ethyl 3-(acridin-9-ylamino)propanoate
CHEMBL2111082
DTXSID20176473
beta-alanine, n-9-acridinyl-, 2-[bis(2-chloroethyl)amino]ethyl ester
878189-87-8
Q27253910
220180-88-1 (free base)
-alanine, n-9-acridinyl-, 2-[bis(2-chloroethyl)amino]ethyl ester

Excerpt	Reference	Relevance
" The adverse event profile was similar between groups; however, patients who received S-303 RBCs were significantly more likely to develop constipation and less likely to suffer supraventricular extrasystoles."	( Therapeutic efficacy and safety of red blood cells treated with a chemical process (S-303) for pathogen inactivation: a Phase III clinical trial in cardiac surgery patients. Benjamin, RJ; Conlan, MG; Corash, L; Lin, JS; McCullough, J; Mintz, PD; Rizzo, RJ; Snyder, E; Spotnitz, WD; Wages, D; Wood, L, 2005)	0.33

Excerpt	Reference	Relevance
"As part of a preclinical safety evaluation program, intravenous toxicity, safety pharmacology, toxicokinetic, and pharmacokinetic studies were conducted in rats and dogs with S-303 RBCs and S-300."	( Preclinical pharmacokinetic and toxicology assessment of red blood cells prepared with S-303 pathogen inactivation treatment. Ciaravino, V; Corash, L; Mufti, N; North, A, 2011)	0.37

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	2 (13.33)	29.6817
2010's	9 (60.00)	24.3611
2020's	4 (26.67)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	4 (26.67%)	5.53%
Reviews	1 (6.67%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	10 (66.67%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Trials	Classes	Roles
2,3-diphosphoglycerate 2,3-Diphosphoglycerate: A highly anionic organic phosphate which is present in human red blood cells at about the same molar ratio as hemoglobin. It binds to deoxyhemoglobin but not the oxygenated form, therefore diminishing the oxygen affinity of hemoglobin. This is essential in enabling hemoglobin to unload oxygen in tissue capillaries. It is also an intermediate in the conversion of 3-phosphoglycerate to 2-phosphoglycerate by phosphoglycerate mutase (EC 5.4.2.1). (From Stryer Biochemistry, 4th ed, p160; Enzyme Nomenclature, 1992, p508). 2,3-bisphosphoglyceric acid : A bisphosphoglyceric acid that is glyceric acid carrying two phospho substituents at positions 2 and 3.	2.1	1	0	bisphosphoglyceric acid; tetronic acid derivative	human metabolite
lactic acid Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed). 2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.	2.1	1	0	2-hydroxy monocarboxylic acid	algal metabolite; Daphnia magna metabolite
methylene blue Methylene Blue: A compound consisting of dark green crystals or crystalline powder, having a bronze-like luster. Solutions in water or alcohol have a deep blue color. Methylene blue is used as a bacteriologic stain and as an indicator. It inhibits GUANYLATE CYCLASE, and has been used to treat cyanide poisoning and to lower levels of METHEMOGLOBIN.. methylene blue : An organic chloride salt having 3,7-bis(dimethylamino)phenothiazin-5-ium as the counterion. A commonly used dye that also exhibits antioxidant, antimalarial, antidepressant and cardioprotective properties.	3.15	1	0	organic chloride salt	acid-base indicator; antidepressant; antimalarial; antimicrobial agent; antioxidant; cardioprotective agent; EC 1.4.3.4 (monoamine oxidase) inhibitor; EC 3.1.1.8 (cholinesterase) inhibitor; EC 4.6.1.2 (guanylate cyclase) inhibitor; fluorochrome; histological dye; neuroprotective agent; physical tracer
ficusin Ficusin: A naturally occurring furocoumarin, found in PSORALEA. After photoactivation with UV radiation, it binds DNA via single and double-stranded cross-linking.. psoralen : The simplest member of the class of psoralens that is 7H-furo[3,2-g]chromene having a keto group at position 7. It has been found in plants like Psoralea corylifolia and Ficus salicifolia.	3.15	1	0	psoralens	plant metabolite
acridines Acridines: Compounds that include the structure of acridine.. acridine : A polycyclic heteroarene that is anthracene in which one of the central CH groups is replaced by a nitrogen atom.	8.76	15	4	acridines; mancude organic heterotricyclic parent; polycyclic heteroarene	genotoxin
riboflavin vitamin B2 : Any member of a group of vitamers that belong to the chemical structural class called flavins that exhibit biological activity against vitamin B2 deficiency. Symptoms associated with vitamin B2 deficiency include glossitis, seborrhea, angular stomaitis, cheilosis and photophobia. The vitamers include riboflavin and its phosphate derivatives (and includes their salt, ionised and hydrate forms).	3.15	1	0	flavin; vitamin B2	anti-inflammatory agent; antioxidant; cofactor; Escherichia coli metabolite; food colouring; fundamental metabolite; human urinary metabolite; mouse metabolite; photosensitizing agent; plant metabolite

Condition	Relationship Strength	Studies	Trials
Plasmodium falciparum Malaria [description not available]	2.72	2	0
Malaria, Falciparum Malaria caused by PLASMODIUM FALCIPARUM. This is the severest form of malaria and is associated with the highest levels of parasites in the blood. This disease is characterized by irregularly recurring febrile paroxysms that in extreme cases occur with acute cerebral, renal, or gastrointestinal manifestations.	2.72	2	0
Parasitemia The presence of parasites (especially malarial parasites) in the blood. (Dorland, 27th ed)	2.25	1	0
Break-Bone Fever [description not available]	2.15	1	0
Dengue An acute febrile disease transmitted by the bite of AEDES mosquitoes infected with DENGUE VIRUS. It is self-limiting and characterized by fever, myalgia, headache, and rash. SEVERE DENGUE is a more virulent form of dengue.	2.15	1	0
Acute Kidney Failure [description not available]	4.48	1	1
Graft-Versus-Host Disease [description not available]	4.48	1	1
Complication, Postoperative [description not available]	4.48	1	1
Viremia The presence of viruses in the blood.	4.48	1	1
Hepatic Failure [description not available]	4.48	1	1
Acute Hemolytic Transfusion Reaction [description not available]	4.48	1	1
Graft vs Host Disease The clinical entity characterized by anorexia, diarrhea, loss of hair, leukopenia, thrombocytopenia, growth retardation, and eventual death brought about by the GRAFT VS HOST REACTION.	4.48	1	1
Postoperative Complications Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery.	4.48	1	1
Bacteremia The presence of viable bacteria circulating in the blood. Fever, chills, tachycardia, and tachypnea are common acute manifestations of bacteremia. The majority of cases are seen in already hospitalized patients, most of whom have underlying diseases or procedures which render their bloodstreams susceptible to invasion.	4.48	1	1
Liver Failure Severe inability of the LIVER to perform its normal metabolic functions, as evidenced by severe JAUNDICE and abnormal serum levels of AMMONIA; BILIRUBIN; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; LACTATE DEHYDROGENASES; and albumin/globulin ratio. (Blakiston's Gould Medical Dictionary, 4th ed)	4.48	1	1
Acute Kidney Injury Abrupt reduction in kidney function. Acute kidney injury encompasses the entire spectrum of the syndrome including acute kidney failure; ACUTE KIDNEY TUBULAR NECROSIS; and other less severe conditions.	4.48	1	1
Transfusion Reaction Complications of BLOOD TRANSFUSION. Included adverse reactions are common allergic and febrile reactions; hemolytic (delayed and acute) reactions; and other non-hemolytic adverse reactions such as infections and adverse immune reactions related to immunocompatibility.	4.48	1	1
Thalassemias [description not available]	2.21	1	0
Thalassemia A group of hereditary hemolytic anemias in which there is decreased synthesis of one or more hemoglobin polypeptide chains. There are several genetic types with clinical pictures ranging from barely detectable hematologic abnormality to severe and fatal anemia.	2.21	1	0
Extravascular Hemolysis [description not available]	2.1	1	0
Hemolysis The destruction of ERYTHROCYTES by many different causal agents such as antibodies, bacteria, chemicals, temperature, and changes in tonicity.	2.1	1	0
Kidney Failure A severe irreversible decline in the ability of kidneys to remove wastes, concentrate URINE, and maintain ELECTROLYTE BALANCE; BLOOD PRESSURE; and CALCIUM metabolism.	3.41	1	1
Colonic Inertia Symptom characterized by the passage of stool once a week or less.	3.41	1	1
Cardiovascular Stroke [description not available]	3.41	1	1
Acute Disease Disease having a short and relatively severe course.	3.41	1	1
Anemia A reduction in the number of circulating ERYTHROCYTES or in the quantity of HEMOGLOBIN.	3.41	1	1
Constipation Infrequent or difficult evacuation of FECES. These symptoms are associated with a variety of causes, including low DIETARY FIBER intake, emotional or nervous disturbances, systemic and structural disorders, drug-induced aggravation, and infections.	3.41	1	1
Myocardial Infarction NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION).	3.41	1	1
Renal Insufficiency Conditions in which the KIDNEYS perform below the normal level in the ability to remove wastes, concentrate URINE, and maintain ELECTROLYTE BALANCE; BLOOD PRESSURE; and CALCIUM metabolism. Renal insufficiency can be classified by the degree of kidney damage (as measured by the level of PROTEINURIA) and reduction in GLOMERULAR FILTRATION RATE.	3.41	1	1

(n,n-bis(2-chloroethyl))-2-aminoethyl-3-((acridin-9-yl)amino)propionate

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Research Demand Index: 11.86

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