Page last updated: 2024-12-06
tiropramide
Description
Research Excerpts
Clinical Trials
Roles
Classes
Pathways
Study Profile
Bioassays
Related Drugs
Related Conditions
Protein Interactions
Research Growth
Market Indicators
Cross-References
ID Source | ID |
---|---|
PubMed CID | 42262 |
CHEMBL ID | 2104688 |
CHEBI ID | 135758 |
SCHEMBL ID | 25693 |
MeSH ID | M0098137 |
Synonyms (36)
Synonym |
---|
tiropramide |
maioral |
cr-605 |
tirospan |
brn 4162600 |
tiropramida [inn-spanish] |
(+-)-alpha-(benzoylamino)-4-(2-(diethylamino)ethoxy)-n,n-dipropylbenzenepropanamide |
dl-alpha-benzamido-para-(2-(diethylamino)ethoxy)-n,n-dipropylhydrocinnamamide |
tiropramidum [inn-latin] |
benzenepropanamide, alpha-(benzoylamino)-4-(2-(diethylamino)ethoxy)-n,n-dipropyl-, (+-)- |
tiropramida [spanish] |
dl-alpha-benzamido-p-(2-(diethylamino)ethoxy)-n,n-dipropylhydrocinnamamide |
tiropramide [inn] |
o-(diethylaminoethyl)-n-benzoyl-dl-tyrosyl-di-n-propylamide |
D07087 |
tiropramide (inn) |
55837-29-1 |
CHEBI:135758 |
tiropramida |
r7s0904cn2 , |
unii-r7s0904cn2 |
tiropramidum |
CHEMBL2104688 |
AKOS015909639 |
SCHEMBL25693 |
dl-.alpha.-benzamido-p-(2-(diethylamino)ethoxy)-n,n-dipropylhydrocinnamamide |
tiropramide [mi] |
(+/-)-.alpha.-benzamido-p-(2-(diethylamino)ethoxy)-n,n-dipropylhydrocinnamamide |
tiropramide [who-dd] |
n-(2-{4-[2-(diethylamino)ethoxy]phenyl}-1-(dipropylcarbamoyl)ethyl)benzenecarboximidic acid |
n-[3-[4-[2-(diethylamino)ethoxy]phenyl]-1-(dipropylamino)-1-oxopropan-2-yl]benzamide |
DB13091 |
Q7809264 |
DTXSID70866514 |
(+/-)-tiropramide |
n-(3-(4-(2-(diethylamino)ethoxy)phenyl)-1-(dipropylamino)-1-oxopropan-2-yl)benzamide |
Research Excerpts
Overview
Tiropramide is an antispasmodic drug that has a chiral center.
Excerpt | Reference | Relevance |
---|---|---|
"Tiropramide is an antispasmodic drug that has a chiral center. " | ( Enantioseparation of tiropramide by HPLC. Choi, ES; Heo, KS; Lee, W; Park, JH; Ryoo, JJ, 2004) | 2.09 |
Actions
Tiropramide was found to inhibit both Ca uptake and Ca release in the guinea pig urinary bladder. It did not affect cAMP and cGMP levels in the smooth muscles of the urethra, stomach and intestines.
Excerpt | Reference | Relevance |
---|---|---|
"In tiropramide, the lower boundary of CI computed from ICA or PCA results was less than 0.800 for the 3 small sample sizes (n = 22, 16, 10), but that of NCA results was less than 0.800 for only the smallest sample size (n = 10)." | ( Compartmental approach to assess bioequivalence compared to the noncompartmental approach. Kang, D; Kim, BH; Kim, SE; Zheng, R, 2016) | 0.95 |
"Tiropramide at the lower concentrations did not affect cAMP and cGMP levels in the smooth muscles of the urethra, stomach and intestines." | ( [Experimental studies of urinary incontinence. Effect of tiropramide on the urinary stage and evacuation]. Ando, M; Dokita, S; Hirano, S; Kondo, S; Morita, T; Tsuchida, S, 1992) | 1.25 |
"3. Tiropramide was found to inhibit both Ca uptake and Ca release in the guinea pig urinary bladder." | ( Pharmacological properties of tiropramide, an antispasmodic drug. Hisayama, T; Iwase, M; Nagai, H; Sakuma, N; Takayanagi, I, 1989) | 1.08 |
Pharmacokinetics
Excerpt | Reference | Relevance |
---|---|---|
" bolus the plasma levels of tiropramide are consistent with a three-compartment open pharmacokinetic model." | ( Pharmacokinetics of tiropramide after single doses in man. Arigoni, R; Chisté, R; Drovanti, A; Makovec, F; Senin, P; Setnikar, I, 1986) | 0.89 |
" Cmax values of test and reference formulations were 93." | ( Pharmacokinetics and bioequivalence of tiropramide in healthy volunteers. Chung, YB; Kwon, OS; Park, YJ, 2003) | 0.59 |
"A pharmacokinetic interaction between oral DA-8159 and amlodipine was evaluated in male Sprague-Dawley rats." | ( Negligible pharmacokinetic interaction between oral DA-8159, a new erectogenic, and amlodipine in rats. Kim, EJ; Kwon, JW; Lee, JH; Lee, MG; Yoo, M, 2006) | 0.33 |
Bioavailability
Excerpt | Reference | Relevance |
---|---|---|
" Bioavailability differences for Cmax and AUC0-->last were -2." | ( Pharmacokinetics and bioequivalence of tiropramide in healthy volunteers. Chung, YB; Kwon, OS; Park, YJ, 2003) | 0.59 |
Dosage Studied
Excerpt | Relevance | Reference |
---|---|---|
" The knowledge gained by these studies was used to predict drug degradation profiles, which help analyse any impurities in the dosage form." | ( Chromatographic separation of tiropramide hydrochloride and its degradation products along with their structural characterization using liquid chromatography quadrupole time-of-flight tandem mass spectrometry and nuclear magnetic resonance. Gananadhamu, S; Golla, VM; Kushwah, BS; Naik, DD; Tidke, M, 2023) | 1.2 |
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
Drug Classes (1)
Class | Description |
---|---|
phenylalanine derivative | An amino acid derivative resulting from reaction of alanine at the amino group or the carboxy group, or from the replacement of any hydrogen of phenylalanine by a heteroatom. The definition normally excludes peptides containing phenylalanine residues. |
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] |
Research
Studies (36)
Timeframe | Studies, This Drug (%) | All Drugs % |
---|---|---|
pre-1990 | 22 (61.11) | 18.7374 |
1990's | 4 (11.11) | 18.2507 |
2000's | 8 (22.22) | 29.6817 |
2010's | 1 (2.78) | 24.3611 |
2020's | 1 (2.78) | 2.80 |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Market Indicators
Research Demand Index: 50.05
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be very strong demand-to-supply ratio for research on this compound.
| This Compound (50.05) All Compounds (24.57) |
Study Types
Publication Type | This drug (%) | All Drugs (%) |
---|---|---|
Trials | 12 (31.58%) | 5.53% |
Reviews | 0 (0.00%) | 6.00% |
Case Studies | 0 (0.00%) | 4.05% |
Observational | 0 (0.00%) | 0.25% |
Other | 26 (68.42%) | 84.16% |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Clinical Trials (1)
Trial Overview
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
Comparative and Analytical Study for Effectiveness and Safety of Tiropramide HCl and Octylonium Bromide in the Treatment of Irritable Bowel Syndrome: Mullticenter, Randomized, Double Blind, Active Controlled Study [NCT01629212] | Phase 4 | 0 participants | Interventional | 2011-12-31 | Recruiting | ||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |