methadone has been researched along with Constipation in 23 studies
Methadone: A synthetic opioid that is used as the hydrochloride. It is an opioid analgesic that is primarily a mu-opioid agonist. It has actions and uses similar to those of MORPHINE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1082-3)
methadone : A racemate comprising equimolar amounts of dextromethadone and levomethadone. It is a opioid analgesic which is used as a painkiller and as a substitute for heroin in the treatment of heroin addiction.
6-(dimethylamino)-4,4-diphenylheptan-3-one : A ketone that is heptan-3-one substituted by a dimethylamino group at position 6 and two phenyl groups at position 4.
Constipation: Infrequent or difficult evacuation of FECES. These symptoms are associated with a variety of causes, including low DIETARY FIBER intake, emotional or nervous disturbances, systemic and structural disorders, drug-induced aggravation, and infections.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The efficacy and safety of oral lubiprostone for relieving symptoms of opioid-induced constipation (OIC) in patients with chronic noncancer pain were evaluated in a randomized, double-blind, placebo-controlled study." | 9.27 | Efficacy and Safety of Lubiprostone in Patients with Opioid-Induced Constipation: Phase 3 Study Results and Pooled Analysis of the Effect of Concomitant Methadone Use on Clinical Outcomes. ( Cryer, B; Drossman, DA; Losch-Beridon, T; Mareya, SM; Mazen Jamal, M; Spierings, ELH; Wang, M, 2018) |
| "To evaluate the efficacy of methylnaltrexone, the first peripheral opioid receptor antagonist, in treating chronic methadone-induced constipation." | 9.09 | Methylnaltrexone for reversal of constipation due to chronic methadone use: a randomized controlled trial. ( Foss, JF; Karrison, T; Moss, J; O'Connor, M; Osinski, J; Roizen, MF; Yuan, CS, 2000) |
| "Preference for sweet-tasting foods, weight gain, and constipation characterize patients receiving methadone maintenance treatment (MMT)." | 8.02 | The prevalence of constipation and its relation to sweet taste preference among patients receiving methadone maintenance treatment. ( Adelson, M; Peles, E; Sason, A; Schreiber, S, 2021) |
| "Opioid-induced constipation (OIC) is one of the major side effects in patients receiving methadone maintenance treatment (MMT)." | 7.81 | Opioid-induced constipation reversal in response to placebo in a patient with a history of IBS receiving methadone maintenance therapy. ( Rehm, J; Samokhvalov, AV, 2015) |
| "Postoperatively, he developed OIC and Ogilvie syndrome, then following treatment with methylnaltrexone experienced an acute bowel perforation." | 5.51 | Methylnaltrexone-Associated Bowel Perforation in Postoperative Opioid-Induced Constipation and Ogilvie Syndrome: A Case Report. ( Blackney, KA; Edwards, DA; Kamdar, NV; Liu, CA, 2019) |
| "Constipation is a common symptom in cancer patients, especially in those who are receiving opioid analgesics for pain." | 5.30 | Reduction in constipation and laxative requirements following opioid rotation to methadone: a report of four cases. ( Bruera, E; Daeninck, PJ, 1999) |
| " First-pass glucuronidation limits systemic bioavailability of oral naloxone." | 5.28 | Treatment of opioid-induced constipation with oral naloxone: a pilot study. ( Culpepper-Morgan, JA; Foley, K; Houde, RW; Inturrisi, CE; Kreek, MJ; Marsh, F; Portenoy, RK, 1992) |
| "The efficacy and safety of oral lubiprostone for relieving symptoms of opioid-induced constipation (OIC) in patients with chronic noncancer pain were evaluated in a randomized, double-blind, placebo-controlled study." | 5.27 | Efficacy and Safety of Lubiprostone in Patients with Opioid-Induced Constipation: Phase 3 Study Results and Pooled Analysis of the Effect of Concomitant Methadone Use on Clinical Outcomes. ( Cryer, B; Drossman, DA; Losch-Beridon, T; Mareya, SM; Mazen Jamal, M; Spierings, ELH; Wang, M, 2018) |
| "To evaluate the efficacy of methylnaltrexone, the first peripheral opioid receptor antagonist, in treating chronic methadone-induced constipation." | 5.09 | Methylnaltrexone for reversal of constipation due to chronic methadone use: a randomized controlled trial. ( Foss, JF; Karrison, T; Moss, J; O'Connor, M; Osinski, J; Roizen, MF; Yuan, CS, 2000) |
| "Preference for sweet-tasting foods, weight gain, and constipation characterize patients receiving methadone maintenance treatment (MMT)." | 4.02 | The prevalence of constipation and its relation to sweet taste preference among patients receiving methadone maintenance treatment. ( Adelson, M; Peles, E; Sason, A; Schreiber, S, 2021) |
| "The present study shows that patients affected by opioid-dependence in OST with methadone and buprenorphine have a high prevalence of constipation and reduced QoL." | 3.83 | High prevalence of constipation and reduced quality of life in opioid-dependent patients treated with opioid substitution treatments. ( Addolorato, G; Casari, R; Cossari, A; Faccini, M; Gasbarrini, A; Lugoboni, F; Mirijello, A; Zamboni, L, 2016) |
| "Opioid-induced constipation (OIC) is one of the major side effects in patients receiving methadone maintenance treatment (MMT)." | 3.81 | Opioid-induced constipation reversal in response to placebo in a patient with a history of IBS receiving methadone maintenance therapy. ( Rehm, J; Samokhvalov, AV, 2015) |
| "A case of severe constipation is described in a 75-year- old cancer patient receiving methadone for pain." | 3.77 | Neostigmine for the treatment of gastrointestinal atony: a report of one case. ( Papa, P; Turconi, L, 2011) |
| "In this preliminary study, we evaluated the effects of methylnaltrexone, a peripheral opioid-receptor antagonist, on chronic opioid-induced gut motility and transit changes in four subjects with chronic methadone-induced constipation." | 3.70 | Effects of intravenous methylnaltrexone on opioid-induced gut motility and transit time changes in subjects receiving chronic methadone therapy: a pilot study. ( Foss, FJ; Moss, J; O'Connor, M; Osinski, J; Roizen, FM; Yuan, SC, 1999) |
| "Postoperatively, he developed OIC and Ogilvie syndrome, then following treatment with methylnaltrexone experienced an acute bowel perforation." | 1.51 | Methylnaltrexone-Associated Bowel Perforation in Postoperative Opioid-Induced Constipation and Ogilvie Syndrome: A Case Report. ( Blackney, KA; Edwards, DA; Kamdar, NV; Liu, CA, 2019) |
| "IV-PCA provided timely, safe and useful analgesia for patients with severe breakthrough pain and may be useful to help titration of opioids, weaning to oral analgesia and to decide for interventional procedures." | 1.40 | Safety profile of intravenous patient-controlled analgesia for breakthrough pain in cancer patients: a case series study. ( Ashmawi, HA; Cascudo, GM; de Santana Neto, J; Guimaraes, GM; Neto, JO; Sousa, AM, 2014) |
| "Constipation is a common symptom in cancer patients, especially in those who are receiving opioid analgesics for pain." | 1.30 | Reduction in constipation and laxative requirements following opioid rotation to methadone: a report of four cases. ( Bruera, E; Daeninck, PJ, 1999) |
| " First-pass glucuronidation limits systemic bioavailability of oral naloxone." | 1.28 | Treatment of opioid-induced constipation with oral naloxone: a pilot study. ( Culpepper-Morgan, JA; Foley, K; Houde, RW; Inturrisi, CE; Kreek, MJ; Marsh, F; Portenoy, RK, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (13.04) | 18.7374 |
| 1990's | 6 (26.09) | 18.2507 |
| 2000's | 5 (21.74) | 29.6817 |
| 2010's | 8 (34.78) | 24.3611 |
| 2020's | 1 (4.35) | 2.80 |
| Authors | Studies |
|---|---|
| Sason, A | 1 |
| Adelson, M | 1 |
| Schreiber, S | 1 |
| Peles, E | 1 |
| Spierings, ELH | 1 |
| Drossman, DA | 1 |
| Cryer, B | 1 |
| Mazen Jamal, M | 1 |
| Losch-Beridon, T | 1 |
| Mareya, SM | 1 |
| Wang, M | 1 |
| Haber, PS | 1 |
| Elsayed, M | 1 |
| Espinoza, D | 1 |
| Lintzeris, N | 1 |
| Veillard, AS | 1 |
| Hallinan, R | 1 |
| Blackney, KA | 1 |
| Kamdar, NV | 1 |
| Liu, CA | 1 |
| Edwards, DA | 1 |
| Sousa, AM | 1 |
| de Santana Neto, J | 1 |
| Guimaraes, GM | 1 |
| Cascudo, GM | 1 |
| Neto, JO | 1 |
| Ashmawi, HA | 1 |
| Samokhvalov, AV | 1 |
| Rehm, J | 1 |
| Lugoboni, F | 1 |
| Mirijello, A | 1 |
| Zamboni, L | 1 |
| Faccini, M | 1 |
| Casari, R | 1 |
| Cossari, A | 1 |
| Gasbarrini, A | 1 |
| Addolorato, G | 1 |
| Garlassi, E | 1 |
| Rossi, G | 1 |
| Bedini, A | 1 |
| Richeldi, L | 1 |
| Papa, P | 1 |
| Turconi, L | 1 |
| Yennurajalingam, S | 1 |
| Braiteh, F | 1 |
| Bruera, E | 2 |
| Langrod, J | 1 |
| Lowinson, J | 1 |
| Ruiz, P | 1 |
| Cheskin, LJ | 1 |
| Chami, TN | 1 |
| Johnson, RE | 1 |
| Jaffe, JH | 1 |
| Yuan, CS | 3 |
| Foss, JF | 3 |
| O'Connor, M | 3 |
| Moss, J | 3 |
| Roizen, MF | 2 |
| Daeninck, PJ | 1 |
| Yuan, SC | 1 |
| Foss, FJ | 1 |
| Osinski, J | 2 |
| Roizen, FM | 1 |
| Karrison, T | 1 |
| Scholz, M | 1 |
| Stephenson, J | 1 |
| Culpepper-Morgan, JA | 1 |
| Inturrisi, CE | 1 |
| Portenoy, RK | 1 |
| Foley, K | 1 |
| Houde, RW | 1 |
| Marsh, F | 1 |
| Kreek, MJ | 1 |
| Yaffe, GJ | 1 |
| Strelinger, RW | 1 |
| Parwatikar, S | 1 |
| Cassidy, WJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Pomegranate Juice Consumption by Patients Under Medication for Addiction Treatment as a Regulator of Craving and Blood Redox Status: The Study Protocol of a Randomized Control Trial (the NUTRIDOPE Study)[NCT05861544] | 58 participants (Anticipated) | Interventional | 2023-03-23 | Enrolling by invitation | |||
| Naloxegol for Opioid-Related Gastroparesis: A Double-Blind Study With an Open Label Extension[NCT03036891] | Phase 2 | 0 participants (Actual) | Interventional | 2016-12-29 | Withdrawn | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for methadone and Constipation
| Article | Year |
|---|---|
Pain and terminal delirium research in the elderly.
Topics: Aged; Algorithms; Analgesics, Opioid; Anti-Infective Agents; Constipation; Delirium; Drug Interactio | 2005 |
4 trials available for methadone and Constipation
| Article | Year |
|---|---|
Efficacy and Safety of Lubiprostone in Patients with Opioid-Induced Constipation: Phase 3 Study Results and Pooled Analysis of the Effect of Concomitant Methadone Use on Clinical Outcomes.
Topics: Adult; Analgesics, Opioid; Chloride Channel Agonists; Chronic Pain; Constipation; Double-Blind Metho | 2018 |
Assessment of nalmefene glucuronide as a selective gut opioid antagonist.
Topics: Adult; Arousal; Autonomic Nervous System; Constipation; Dose-Response Relationship, Drug; Gastrointe | 1995 |
Methylnaltrexone for reversal of constipation due to chronic methadone use: a randomized controlled trial.
Topics: Adult; Analgesics, Opioid; Constipation; Double-Blind Method; Female; Gastrointestinal Transit; Huma | 2000 |
Oral methylnaltrexone for opioid-induced constipation.
Topics: Administration, Oral; Adult; Analgesics, Opioid; Constipation; Humans; Methadone; Naltrexone; Narcot | 2000 |
18 other studies available for methadone and Constipation
| Article | Year |
|---|---|
The prevalence of constipation and its relation to sweet taste preference among patients receiving methadone maintenance treatment.
Topics: Constipation; Humans; Methadone; Opiate Substitution Treatment; Opioid-Related Disorders; Prevalence | 2021 |
Constipation and other common symptoms reported by women and men in methadone and buprenorphine maintenance treatment.
Topics: Adult; Analgesics, Opioid; Australia; Buprenorphine; Case-Control Studies; Constipation; Depression; | 2017 |
Methylnaltrexone-Associated Bowel Perforation in Postoperative Opioid-Induced Constipation and Ogilvie Syndrome: A Case Report.
Topics: Analgesics, Opioid; Colonic Pseudo-Obstruction; Constipation; Decompression, Surgical; Humans; Hydro | 2019 |
Safety profile of intravenous patient-controlled analgesia for breakthrough pain in cancer patients: a case series study.
Topics: Adult; Analgesia, Patient-Controlled; Analgesics; Breakthrough Pain; Constipation; Female; Fentanyl; | 2014 |
Opioid-induced constipation reversal in response to placebo in a patient with a history of IBS receiving methadone maintenance therapy.
Topics: Analgesics, Opioid; Constipation; Cross-Over Studies; Female; Humans; Irritable Bowel Syndrome; Laxa | 2015 |
High prevalence of constipation and reduced quality of life in opioid-dependent patients treated with opioid substitution treatments.
Topics: Adult; Analgesics, Opioid; Buprenorphine; Constipation; Female; Heroin Dependence; Humans; Italy; Ma | 2016 |
Unexpected identification of bilateral masses in an asymptomatic heavy smoker.
Topics: Constipation; Humans; Male; Methadone; Middle Aged; Mineral Oil; Pneumonia, Lipid; Smoking; Tomograp | 2010 |
Neostigmine for the treatment of gastrointestinal atony: a report of one case.
Topics: Aged; Analgesics, Opioid; Constipation; Female; Humans; Injections, Subcutaneous; Methadone; Neoplas | 2011 |
Methadone treatment and physical complaints: a clinical analysis.
Topics: Bone Diseases; Constipation; Female; Humans; Male; Methadone; Sexual Dysfunction, Physiological; Sle | 1981 |
Drugs for pain.
Topics: Acetaminophen; Administration, Oral; Amitriptyline; Analgesics; Analgesics, Non-Narcotic; Analgesics | 1998 |
Gut motility and transit changes in patients receiving long-term methadone maintenance.
Topics: Adult; Breath Tests; Chromatography, Gas; Constipation; Female; Gastrointestinal Motility; Gastroint | 1998 |
Reduction in constipation and laxative requirements following opioid rotation to methadone: a report of four cases.
Topics: Analgesics, Opioid; Cathartics; Constipation; Female; Humans; Methadone; Middle Aged; Morphine | 1999 |
Effects of intravenous methylnaltrexone on opioid-induced gut motility and transit time changes in subjects receiving chronic methadone therapy: a pilot study.
Topics: Adult; Analgesics, Opioid; Constipation; Female; Gastrointestinal Motility; Gastrointestinal Transit | 1999 |
Managing constipation that's opioid-induced.
Topics: Administration, Oral; Adult; Analgesics, Opioid; Breast Neoplasms; Chemistry, Pharmaceutical; Consti | 2000 |
Methylnaltrexone reverses opioid-induced constipation.
Topics: Administration, Oral; Analgesics, Opioid; Clinical Trials, Phase II as Topic; Constipation; Humans; | 2002 |
Treatment of opioid-induced constipation with oral naloxone: a pilot study.
Topics: Adult; Constipation; Dose-Response Relationship, Drug; Female; Humans; Male; Methadone; Middle Aged; | 1992 |
Physical symptom complaints of patients on methadone maintenance.
Topics: Constipation; Dose-Response Relationship, Drug; Female; Heroin Dependence; Humans; Male; Methadone; | 1973 |
Maintenance methadone treatment of drug dependency.
Topics: Administration, Oral; Adult; Constipation; Erectile Dysfunction; Evaluation Studies as Topic; Female | 1972 |