Page last updated: 2024-12-07

travocort

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

Travocort: isoconazole & diflucortolone 21-valerate combination [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	133140
MeSH ID	M0074298

Synonyms (4)

Synonym
pregna-1,4-diene-3,20-dione, 6,9-difluoro-11-hydroxy-16-methyl-21-((1-oxopentyl)oxy)-, (6alpha,11beta,16alpha)-, mixt. with 1-(2-(2,4-dichlorophenyl)-2-((2,6-dichlorophenyl)methoxy)ethyl)-1h-imidazole mononitrate
travocort
78940-01-9
1-[2-(2,4-dichlorophenyl)-2-[(2,6-dichlorophenyl)methoxy]ethyl]imidazole;[2-[(6s,8s,10s,11s,13s,14s,16r,17s)-6,9-difluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-7,8,11,12,14,15,16,17-octahydro-6h-cyclopenta[a]phenanthren-17-yl]-2-oxoethyl] pentanoate;nitric

Research Excerpts

Overview

Travocort is a combination of 1% isoconazole nitrate (ISN) and 0.1% diflucortolone valerate (DFV) It is a potent topical corticosteroid with low systemic absorption and therefore a low risk of systemic glucocorticoid side-effects.

Excerpt	Reference	Relevance
"Travocort is a combination of 1% isoconazole nitrate (ISN), a broad-spectrum imidazole with established antimicrobial activity and antimycotic efficacy, and 0.1% diflucortolone valerate (DFV), a potent topical corticosteroid with low systemic absorption and therefore a low risk of systemic glucocorticoid side-effects."	( The advantages of topical combination therapy in the treatment of inflammatory dermatomycoses. Friedrich, M; Havlickova, B, 2008)	1.07

Compound-Compound Interactions

Excerpt	Reference	Relevance
" The rapid improvement observed with Travocort treatment, combined with favourable safety and tolerability, results in higher patient satisfaction, and therefore, can be an effective tool to increase treatment adherence in patients with dermatomycoses accompanied by inflammatory signs and symptoms."	( Isoconazole nitrate: a unique broad-spectrum antimicrobial azole effective in the treatment of dermatomycoses, both as monotherapy and in combination with corticosteroids. Veraldi, S, 2013)	0.66

Bioavailability

Excerpt	Reference	Relevance
" Studies show, however, that the addition of a topical corticosteroid to imidazole therapy increases the bioavailability and prolongs the activity of the antimycotic, while rapidly reducing inflammatory symptoms."	( The advantages of topical combination therapy in the treatment of inflammatory dermatomycoses. Friedrich, M; Havlickova, B, 2008)	0.35
" Isoconazole nitrate (ISN) is a broad-spectrum antimicrobial agent with a highly effective antimycotic and gram-positive antibacterial activity, a rapid rate of absorption and low systemic exposure potential."	( Isoconazole nitrate: a unique broad-spectrum antimicrobial azole effective in the treatment of dermatomycoses, both as monotherapy and in combination with corticosteroids. Veraldi, S, 2013)	0.39

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (21)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	2 (9.52)	18.7374
1990's	1 (4.76)	18.2507
2000's	13 (61.90)	29.6817
2010's	5 (23.81)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 89.67

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be very strong demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	89.67 (24.57)
Research Supply Index	3.18 (2.92)
Research Growth Index	5.54 (4.65)
Search Engine Demand Index	153.49 (26.88)
Search Engine Supply Index	2.00 (0.95)

This Compound (89.67)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	2 (9.52%)	5.53%
Reviews	2 (9.52%)	6.00%
Case Studies	14 (66.67%)	4.05%
Observational	0 (0.00%)	0.25%
Other	3 (14.29%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Trials	Classes
imidazole imidazole: RN given refers to parent cpd. 1H-imidazole : An imidazole tautomer which has the migrating hydrogen at position 1.	2.04	1	0	imidazole
isoconazole 1-{2-[(2,6-dichlorobenzyl)oxy]-2-(2,4-dichlorophenyl)ethyl}imidazole : A member of the class of imidazoles that carries a 2-[(2,6-dichlorobenzyl)oxy]-2-(2,4-dichlorophenyl)ethyl group at position 1.. isoconazole : A racemate comprising equimolar amounts of (R)- and (S)-isoconazole. A broad-spectrum antibacterial drug used (as its nitrate salt) for treatment of dermatomycoses.	7.26	17	2	dichlorobenzene; ether; imidazoles
miconazole Miconazole: An imidazole antifungal agent that is used topically and by intravenous infusion.. 1-[2-(2,4-dichlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl]imidazole : A member of the class of imidazoles that is 1-(2,4-dichlorophenyl)-2-(imidazol-1-yl)ethanol in which the hydroxyl hydrogen is replaced by a 2,4-dichlorobenzyl group.. miconazole : A racemate composed of equimolar amounts of (R)- and (S)-miconazole. Used (as its nitrate salt) to treat skin infections such as athlete's foot, jock itch, ringworm and other fungal skin infections. It inhibits the synthesis of ergosterol, a critical component of fungal cell membranes.	7.98	21	2	dichlorobenzene; ether; imidazoles
fluocortolone Fluocortolone: A glucocorticoid with anti-inflammatory activity used topically for various skin disorders.	4.31	2	2	21-hydroxy steroid
diflucortolone valerate diflucortolone valerate: Rn given refers to (6alpha,11beta,16alpha)-isomer	5.08	13	0	corticosteroid hormone
diflucortolone Diflucortolone: A topical glucocorticoid used in various DERMATOSES. It is absorbed through the skin, bound to plasma albumin, and may cause adrenal suppression. It is also administered as the valerate.	7.98	21	2	21-hydroxy steroid

Condition	Relationship Strength	Studies	Trials
Allergic Contact Dermatitis [description not available]	2.15	1	0
Dermatitis Medicamentosa [description not available]	2.15	1	0
Dermatophytoses [description not available]	4.57	9	0
Tinea Fungal infection of keratinized tissues such as hair, skin and nails. The main causative fungi include MICROSPORUM; TRICHOPHYTON; and EPIDERMOPHYTON.	4.57	9	0
Dermatitis, Allergic Contact A contact dermatitis due to allergic sensitization to various substances. These substances subsequently produce inflammatory reactions in the skin of those who have acquired hypersensitivity to them as a result of prior exposure.	2.15	1	0
Co-infection [description not available]	3.4	2	0
Dermatomycoses Superficial infections of the skin or its appendages by any of various fungi.	6.72	7	2
Bacterial Skin Diseases [description not available]	3.4	2	0
Skin Diseases, Bacterial Skin diseases caused by bacteria.	3.4	2	0
Bacterial Infections, Gram-Positive [description not available]	3	1	0
Gram-Positive Bacterial Infections Infections caused by bacteria that retain the crystal violet stain (positive) when treated by the gram-staining method.	3	1	0
Innate Inflammatory Response [description not available]	5	3	1
Itching [description not available]	2.49	2	0
Erythrasma A chronic bacterial infection of major folds of the skin, caused by Corynebacterium minutissimum.	2.08	1	0
Inflammation A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.	5	3	1
Pruritus An intense itching sensation that produces the urge to rub or scratch the skin to obtain relief.	2.49	2	0
Candida Infection [description not available]	2.08	1	0
Candidiasis Infection with a fungus of the genus CANDIDA. It is usually a superficial infection of the moist areas of the body and is generally caused by CANDIDA ALBICANS. (Dorland, 27th ed)	2.08	1	0
Intertrigo A superficial dermatitis occurring on skin surfaces in contact with each other, such as the axillae, neck creases, intergluteal fold, between the toes, etc. Obesity is a predisposing factor. The condition is caused by moisture and friction and is characterized by erythema, maceration, burning, and exudation.	2.96	4	0
Nail Fungus [description not available]	2.04	1	0
Foot Dermatoses Skin diseases of the foot, general or unspecified.	2.04	1	0
Onychomycosis A fungal infection of the nail, usually caused by DERMATOPHYTES; YEASTS; or nondermatophyte MOLDS.	2.04	1	0
Candidiasis, Cutaneous Candidiasis of the skin manifested as eczema-like lesions of the interdigital spaces, perleche, or chronic paronychia. (Dorland, 27th ed)	2.73	3	0
Balanitis Inflammation of the head of the PENIS, glans penis.	2.04	1	0
Dermatitis, Eczematous [description not available]	2.04	1	0
Eczema A pruritic papulovesicular dermatitis occurring as a reaction to many endogenous and exogenous agents (Dorland, 27th ed).	2.04	1	0
Athlete's Foot [description not available]	2.44	2	0
Tinea Pedis Dermatological pruritic lesion in the feet, caused by Trichophyton rubrum, T. mentagrophytes, or Epidermophyton floccosum.	2.44	2	0
Allergic Reaction [description not available]	3.34	1	1
Hypersensitivity Altered reactivity to an antigen, which can result in pathologic reactions upon subsequent exposure to that particular antigen.	3.34	1	1

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